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KCNE3 Gene

protein-coding GIFtS: 62

GC11M073843

potassium voltage-gated channel, Isk-related family, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp781H21101 ^²
HOKPP ^¹, ², ⁵
MGC102685 ^²
MGC129924 ^²
MiRP2 ^¹, ²

Descriptions
MinK-related peptide 2 ^², ³
Minimum potassium ion channel-related peptide 2 ^², ³
Potassium channel subunit beta MiRP2 ^³
cardiac voltage-gated potassium channel accessory subunit ^²
potassium voltage-gated channel subfamily E member 3 ^²
potassium voltage-gated channel, Isk-related family, member 3 ^²
voltage-gated K+ channel subunit MIRP2 ^²

External Ids
HGNC: 6243¹
Entrez Gene: 10008²
UniProtKB: Q9Y6H6³
Ensembl: ENSG00000175538⁷

Search outside databases for aliases for KCNE3 gene

Previous GC identifers: GC11M076494 GC11M075705 GC11M074388 GC11M073892

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNE3:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a

member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I

membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to

modulate the gating kinetics and enhance stability of the multimeric complex. This gene is

prominently expressed in the kidney. A missense mutation in this gene is associated with

hypokalemic periodic paralysis. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel

complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of

the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold

voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential

(RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated

potassium channel involved in chloride secretion

Gene Wiki entry for KCNE3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNE3 gene

Entrez Gene cytogenetic band: 11q13-q14 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4

KCNE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M073843: (about GC identifiers)

Start:	73,843,534 bp from pter
End:	73,856,248 bp from pter
Size:	12,715 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily E member 3

Size: 103 amino acids; 11710 Da

Subunit: Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1

Subcellular location: Membrane; Single-pass type I membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005463.1

ENSEMBL proteins:

ENSP00000310557

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNE3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNE3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KCNE3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNE3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCNE3

Assays for KCNE3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y6H6

ProtoNet protein and cluster: Q9Y6H6

2 Blocks protein families:

IPB000369 KCNE voltage-gated K+ channel beta subunit family signature

IPB005426 KCNE voltage-gated K+ channel beta-3 subunit signature

UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6

Similarity: Belongs to the potassium channel KCNE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005472

Applied Biosystems Silencer® siRNAs for KCNE3

Sigma-Aldrich siRNA and siRNA Panels for KCNE3

Sigma-Aldrich shRNA Panels and shRNA for KCNE3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNE3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005472
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005472
untagged cDNA clones in CMV expression vector (see all 2): BC032235

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005472

UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel

complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of

the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold

voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential

(RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated

potassium channel involved in chloride secretion

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for KCNE3

5/12 Interacting proteins for KCNE3 (ENSP00000310557³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNQ1	ENSP00000370153³	STRING (score=.986)
KCNE1	ENSP00000337255³	STRING (score=.951)
SCN4A	ENSP00000006839³	STRING (score=.936)
KCNE2	ENSP00000290310³	STRING (score=.919)
KCNH2	ENSP00000262186³	STRING (score=.919)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNE3 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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1 Novoseek chemical compound relationship for KCNE3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	70.06	14	11207363 (2), 14504341 (1), 19306396 (1), 16308347 (1) (see all 8)

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1 PharmGKB drug compound relationship for KCNE3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA	10646604

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005472

Sigma-Aldrich siRNA and siRNA Panels for KCNE3

Sigma-Aldrich shRNA Panels and shRNA for KCNE3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005472

REFSEQ mRNAs for KCNE3 gene:

NM_005472.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005472

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005472
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005472
                                 untagged cDNA clones in CMV expression vector (see all 2): BC032235

Additional cDNA sequence:

AF076531.1 AF302494.1 AK311876.1 BC110612.2 BC113743.1 CR457209.1 CR936625.1 DQ192291.1

DQ192292.1

5 DOTS entries:

DT.97835845 DT.453074 DT.95353663 DT.120695530 DT.310363

24/93 AceView cDNA sequences (see all 93 ):

CK301015 AI569802 BQ010803 NM_005472 BX089345 BX281441 AA494359 AI221445

BM856487 BQ011369 AI283984 AI679463 BM791046 BM768470 BP375230 AI373216

N45648 AI991557 BE645874 BQ013893 AW194853 CA443748 CA433885 BQ186505

highest scoring ESTs for KCNE3:

AA132718 AA259200 AA127801 AA515221 AF076531 AI148745 AI221445 AW003841 AW081373 AW194853

Unigene Cluster for KCNE3:

Potassium voltage-gated channel, Isk-related family, member 3

Hs.523899 [show with all ESTs]

Unigene Representative Sequence: NM_005472

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNE3

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c
SP1:					-
SP2:			-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for KCNE3

1 Ensembl transcript including schematic representation:

ENST00000310128

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNE3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNE3

¹ / ² / ³

11 probe-sets matching KCNE3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
68986_at²^{, 3}	U95-E	1	1.00	1.00	0.62	0.64	AA132718	0.80	1.00	0.91	1
86424_at²^{, 3}	U95-E	1	1.00	1.00	0.80	0.44	AW003841	0.60	1.00	0.82	1
57223_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.78	AI982768	0.40	1.00	0.76	1
44558_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.17	AI148745	0.60	1.00	0.82	1
68984_at²^{, 3}	U95-E	1	0.88	1.00	0.86	1.02	AA259200	0.80	1.00	0.91	1
222922_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF302494	0.40	1.00	0.76	1
227647_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI692703	0.20	1.00	0.72	1
222923_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF302494	0.40	1.00	0.76	1
222922_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227647_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222923_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNE3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAAATTTAT

SOURCE GeneReport for Unigene cluster: Hs.523899
UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6
Tissue specificity: Widely expressed with highest levels in kidney and moderate levels in small
intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNE3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNE3¹	--	potassium voltage-gated channel, Isk-related family, more	93.6(n) 95.96(a)	485197 XM_542315.2 XP_542315.1
chimpanzee (Pan troglodytes)	KCNE3¹	--	potassium voltage-gated channel, Isk-related family, more	99.68(n) 100(a)	466706 XM_001174917.1 XP_001174917.1
cow (Bos taurus)	KCNE3¹	--	potassium voltage-gated channel, Isk-related family, more	90.24(n) 91.92(a)	527762 XM_606161.1 XP_606161.1
rat (Rattus norvegicus)	Kcne3¹	--	potassium voltage-gated channel, Isk-related subfamily, more	85.11(n) 92.23(a)	63883 NM_022235.2 NP_071571.1
mouse (Mus musculus)	Kcne3^{1, 5}	7⁵	potassium voltage-gated channel, Isk-related subfamily, more^{1, 5}	86.73(n)¹ 93.2(a)¹	57442¹ NM_020574.4¹ NP_065599.1¹ AF076532⁵ AK008744⁵ (see all 10)

About this table Species with no ortholog for KCNE3

ENSEMBL Gene Tree for KCNE3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/200 NCBI SNPs in KCNE3 are shown (see all 200 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 77)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9516^1,2	A,C,F,H,O	73843926(+)	`CTGCTA/GTCAGA`	1	--	ut3¹ ese³		14	MN EU EA WA NS	1582
	rs7789^1,2	A,C,F,H	73843968(-)	`GAAACA/CTGCGT`	1	--	ut3¹		17	MN EU EA WA NA NS	1938
--	rs12271177^1,2	A,C,F,H	73845278(+)	`TTTTCG/ATAATG`	1	--	ut3¹		8	EU EA WA NS	770
	rs11236111^1,2	C,F,H	73845865(+)	`CCTGAT/CGCAGT`	1	--	ut3¹ ese³		4	EU EA NS	380
	rs3867278^1,2	A,C,F	73843069(-)	`ATAAAA/TTAATA`	1	--	ng5¹		4	NS	376
	rs12277342^1,2	C,F,H	73845482(+)	`TTCACG/AGGAGC`	1	--	ut3¹ ese³		4	EU EA NS	364
--	rs35833816^1,2	C,F	73844507(+)	`CCTCCG/ACCTCC`	1	--	ut3¹		4	NS	322
	rs11602732^1,2	F,H	73858137(+)	`ATGAGC/ACTAAC`	1	--	ng3¹		4	EU EA WA	412
--	rs28705219^1,2	C,F	73844514(+)	`CTCCCG/AGGTTC`	1	--	ut3¹		4	NS	318
--	rs41259744^1,2	C,F	73844656(+)	`CCTCAA/C/GGTGAT`	1	--	ut3¹		2	NS	154

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HapMap Linkage Disequilibrium images for KCNE3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604433 disorders: 170400

UniProtKB/Swiss-Prot: KCNE3_HUMAN, Q9Y6H6

Defects in KCNE3 are a cause of periodic paralysis hypokalemic (HOKPP) [MIM:170400]; also

designated HYPOPP. HOKPP is an autosomal dominant disorder manifested by episodic flaccid

generalized muscle weakness associated with falls of serum potassium levels

Defects in KCNE3 are a cause of thyrotoxic hypokalemic periodic paralysis (TPP)

[MIM:188580]. TPP is seen in individuals of all races and manifests as attacks of episodic

weakness with hypokalemia during thyrotoxicosis. TPP is seen most commonly in young Latin American

or Asian men where up to 10% of thyrotoxic patients may have periodic paralysis. In such patients

thyrotoxicosis has often been overlooked for many months. TPP generally occurs as a sporadic

disease, and the periodic paralysis resolves completely with treatment of the thyrotoxicosis,

although the muscle phenotype returns if the patient becomes thyrotoxic again later

1 Novoseek disease relationship for KCNE3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
periodic paralysis	88.89	11	16449802 (3), 14504341 (1), 11207363 (1), 15212652 (1)

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1 PharmGKB disease relationship for KCNE3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Cystic Fibrosis	FA	10646604

About this table

Human Gene Mutation Database: KCNE3
Genetic Association Database: KCNE3
Human Genome Epidemiology Navigator: KCNE3 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/32 PubMed articles for KCNE3 gene (see all 32 ):

A constitutively open potassium channel formed by KCNQ1 and KCNE3. (PubMed id 10646604)^{3, 4, 7} Schroeder B.C....Jentsch T.J. (2000)
No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients. (PubMed id 15212652)^{1, 3, 6} Tang N.L....Cockram C.S. (2004)
MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. (PubMed id 11207363)^{1, 3, 4} Abbott G.W....Goldstein S.A.N. (2001)
Lack of association of the potassium channel-associated peptide MiRP2-R83H variant with periodic paralysis. (PubMed id 14504341)^{1, 3, 6} Sternberg D....Fontaine B. (2003)
Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. (PubMed id 11874988)^{1, 3, 4} Abbott G.W. and Goldstein S.A.N. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis. (PubMed id 12414843)^{3, 4} Dias Da Silva M.R.... Maciel R.M.B. (2002)
Structural determinants of KvLQT1 control by the KCNE family of proteins. (PubMed id 11104781)^{3, 4} Melman Y.F.... McDonald T.V. (2001)
MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PubMed id 10219239)^{2, 3} Abbott G.W.... Goldstein S.A.N. (1999)
Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. (PubMed id 19306396)^{1, 3} Ohno S....Horie M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10008	HGNC: 6243	AceView: KCNE3	Ensembl:ENSG00000175538	euGenes: HUgn10008
ECgene: KCNE3	H-InvDB: KCNE3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for KCNE3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KCNE3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNE3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNE3		Antibodies for KCNE3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNE3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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KCNE3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for KCNE3

Summaries
for KCNE3

Genomic Location
for KCNE3

Proteins
for KCNE3

Protein Domains/
Families
for KCNE3

Gene Function
for KCNE3

Pathways & Interactions
for KCNE3

Drugs & Compounds
for KCNE3

Transcripts
for KCNE3

Expression
for KCNE3

Orthologs
for KCNE3

Paralogs
for KCNE3

SNPs/Variants
for KCNE3

Disorders & Mutations
for KCNE3

Medical News
for KCNE3

Publications
for KCNE3

Search for KCNE3

Genome Databases showing KCNE3

Other Databases showing KCNE3

Specialized Databases showing KCNE3

Licensable Technologies
for KCNE3

Services
for KCNE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNE3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor KCNE3

Summariesfor KCNE3

Genomic Locationfor KCNE3

Proteinsfor KCNE3

Protein Domains/Familiesfor KCNE3

Gene Functionfor KCNE3

Pathways & Interactionsfor KCNE3

Drugs & Compoundsfor KCNE3

Transcriptsfor KCNE3

Expression for KCNE3

Orthologsfor KCNE3

Paralogsfor KCNE3

SNPs/Variantsfor KCNE3

Disorders & Mutationsfor KCNE3

Medical Newsfor KCNE3

Publicationsfor KCNE3

Search for KCNE3

Genome Databases showing KCNE3

Other Databases showing KCNE3

Specialized Databases showing KCNE3

Licensable Technologiesfor KCNE3

Servicesfor KCNE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNE3

Summaries
for KCNE3

Genomic Location
for KCNE3

Proteins
for KCNE3

Protein Domains/
Families
for KCNE3

Gene Function
for KCNE3

Pathways & Interactions
for KCNE3

Drugs & Compounds
for KCNE3

Transcripts
for KCNE3

Expression
for KCNE3

Orthologs
for KCNE3

Paralogs
for KCNE3

SNPs/Variants
for KCNE3

Disorders & Mutations
for KCNE3

Medical News
for KCNE3

Publications
for KCNE3

Licensable Technologies
for KCNE3

Services
for KCNE3