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KCNE2 Gene

protein-coding GIFtS: 63

GC21P034658

potassium voltage-gated channel, Isk-related family, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
ATFB4 ^², ⁵
LQT5 ^²
LQT6 ^², ⁵
MGC138292 ^²
MIRP1 ^², ⁵
MiRP1 ^¹

Descriptions
MinK-related peptide 1 ^³
Minimum potassium ion channel-related peptide 1 ^², ³
Potassium channel subunit beta MiRP1 ^³
cardiac voltage-gated potassium channel accessory subunit 2 ^²
human minK-related peptide 1, potassium channel subunit, MiRP1 ⁹
minK-related peptide-1 ^²
potassium channel subunit, MiRP1 ^²
potassium voltage-gated channel subfamily E member 2 ^²
potassium voltage-gated channel, Isk-related family, member 2 ^²
voltage-gated K+ channel subunit MIRP1 ^²

External Ids
HGNC: 6242¹
Entrez Gene: 9992²
UniProtKB: Q9Y6J6³
Ensembl: ENSG00000159197⁷

Search outside databases for aliases for KCNE2 gene

Previous GC identifers: GC21P032313 GC21P034656

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNE2:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a

member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small

integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to

alter its function. This gene is expressed in heart and muscle and the gene mutations are

associated with cardiac arrhythmia. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel

complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of

the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating

component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2

and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a

voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band: 21q22.12

KCNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P034658:	GeneLoc	Nature:405,311-319
Start:	34,658,193 bp from pter	21,319,354 bp from centromere
End:	34,665,310 bp from pter	21,320,085 bp from centromere
Size:	7,118 bases	732 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	AF071002
genomic clones:	pQ12C8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily E member 2

Size: 123 amino acids; 14472 Da

Subunit: Associates with KCNH2/ERG1. May associate with KCNQ1/KVLQT1, KCNQ2 and KCNQ3. Associates

with HCN1 and probably HCN2 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: A5H1P3 Q52LJ5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_751951.1

ENSEMBL proteins:

ENSP00000290310

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNE2)
	Human Recombinant Proteins from Abnova (KCNE2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IDA	16780588
GO:0005886	plasma membrane	IDA	16780588
GO:0008076	voltage-gated potassium channel complex	TAS	10219239
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for KCNE2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNE2
	Sigma-Aldrich Antibodies for KCNE2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNE2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNE2)
	Novus Biologicals Antibody for KCNE2

Assays for KCNE2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y6J6

ProtoNet protein and cluster: Q9Y6J6

2 Blocks protein families:

IPB000369 KCNE voltage-gated K+ channel beta subunit family signature

IPB005425 KCNE voltage-gated K+ channel beta-2 subunit signature

UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6

Similarity: Belongs to the potassium channel KCNE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNE2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_172201

Applied Biosystems Silencer® siRNAs for KCNE2

Sigma-Aldrich siRNA and siRNA Panels for KCNE2

Sigma-Aldrich shRNA Panels and shRNA for KCNE2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNE2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_172201
Myc/DDK tagged cDNA clone in CMV expression vector: NM_172201
untagged cDNA clone in CMV expression vector: NM_172201

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_172201

UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel

complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of

the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating

component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2

and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a

voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current

Genatlas biochemistry entry for KCNE2:

potassium voltage channel,Isk-related subfamily member,expressed in cardiac and skeletal

muscle,associating with KCNH2 (HERG) to generate a rapid delayed-rectifier channel (differing from

the channel exclusively made of KCNH2),central to the control of the heart rate and rhythm

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcne2):

digestive/alimentary

homeostasis/metabolism

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	TAS	10219239
GO:0015459	potassium channel regulator activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNE2

5/51 Interacting proteins for KCNE2 (ENSP00000290310³) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNQ1	ENSP00000370153³	STRING (score=.999)
KCNH2	ENSP00000262186³	STRING (score=.998)
KCND3	ENSP00000319591³	STRING (score=.995)
KCNA4	ENSP00000328511³	STRING (score=.994)
KCNA5	ENSP00000252321³	STRING (score=.987)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	10219239
GO:0006936	muscle contraction	TAS	10219239
GO:0008015	blood circulation	NAS	10219239
GO:0008016	regulation of heart contraction	TAS	10219239

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNE2 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

2 Novoseek chemical compound relationships for KCNE2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	71.25	27	15368194 (2), 11259355 (1), 18221016 (1), 18634977 (1) (see all 15)
sodium	36.30	7	11259355 (1), 10898405 (1), 10816797 (1), 11050278 (1) (see all 6)

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3 PharmGKB drug compound relationships for KCNE2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	CO FA GN	11101505 10219239 10984545
clarithromycin	FA GN	10219239
sulfamethoxazole	CO FA GN	10984545

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNE2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_172201

Sigma-Aldrich siRNA and siRNA Panels for KCNE2

Sigma-Aldrich shRNA Panels and shRNA for KCNE2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_172201

REFSEQ mRNAs for KCNE2 gene:

NM_172201.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_172201

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_172201
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_172201
                                 untagged cDNA clone in CMV expression vector: NM_172201

Additional cDNA sequence:

AF302095.1 BC093892.1 BC112087.1 DQ192290.1

2 DOTS entries:

DT.440623 DT.100747165

24/26 AceView cDNA sequences (see all 26 ):

BM783832 CB104833 NM_172201 CD619900 CD619897 AF071002 CD619898 AF302095

BG221966 CD619896 CO247601 CO248577 CO249094 CO246762 CO245778 CO249699

CO246672 CO249586 CO249201 CO245917 CO245676 CO250230 CO247449 CO248680

highest scoring ESTs for KCNE2:

AF302095 BG208163 BG221966 AA633404 AF071002 AI246239 AI339609 AI654552 AI962650 BC093892

Unigene Cluster for KCNE2:

Potassium voltage-gated channel, Isk-related family, member 2

Hs.551521 [show with all ESTs]

Unigene Representative Sequence: AF302095

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000290310

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNE2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNE2

¹ / ² / ³

3 probe-sets matching KCNE2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
72248_r_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.00	N62991	0.60	1.00	0.82	1
221095_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005136	0.20	1.00	0.72	1
221095_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.551521
UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6
Tissue specificity: Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney,
colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate,
small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNE2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNE2¹	--	potassium voltage-gated channel, Isk-related family, more	89.7(n) 91.06(a)	403471 XM_544867.2 XP_544867.2
chimpanzee (Pan troglodytes)	KCNE2¹	--	potassium voltage-gated channel, Isk-related family, more	99.19(n) 99.19(a)	746889 XM_001167267.1 XP_001167267.1
cow (Bos taurus)	KCNE2¹	--	potassium voltage-gated channel, Isk-related family, more	85.37(n) 86.18(a)	768025 NM_001077084.1 NP_001070552.1
rat (Rattus norvegicus)	Kcne2¹	--	potassium voltage-gated channel, Isk-related subfamily, more	82.11(n) 82.11(a)	171138 NM_133603.2 NP_598287.1
mouse (Mus musculus)	Kcne2^{1, 5}	16⁵	potassium voltage-gated channel, Isk-related subfamily, more^{1, 5}	82.66(n)¹ 84.55(a)¹	246133¹ NM_134110.2¹ NP_598871.1¹ AK008619⁵ AW048273⁵ (see all 8)

About this table Species with no ortholog for KCNE2

ENSEMBL Gene Tree for KCNE2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/131 NCBI SNPs in KCNE2 are shown (see all 131 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1010667^1,2	C,F,H,O	34657331(+)	`TTGGAA/TGTGGT`	1	--	ng5¹		7	EU EA WA NS	690
	rs11702471^1,2	C,F,H	34656717(+)	`GTTCAT/CAGTAC`	1	--	ng5¹		11	EU EA WA NA NS	934
	rs13048252^1,2	C,F,H	34658036(+)	`ACTCTA/GCCCAA`	1	--	ng5¹		12	EU EA WA NS	1114
--	rs35759083^1,2	C,F	34664670(-)	`TCTGTG/ATGAAA`	1	I/T	mis¹		2	NA NS	170
--	rs11909092^1,2	C,F	34657599(+)	`TCTTTC/TATTGA`	1	--	ng5¹ trp³		4	NS	240
--	rs2234916^1,2	C,F	34664669(+)	`ATTTCA/GCACAG`	1	T/A	mis¹ ese³		2	NS	846
--	rs34886364^1,2	C,F	34657053(+)	`AATTAA/GCCAGG`	1	--	ng5¹		4	NS	362
--	rs41260744^1,2	C,F	34658254(+)	`CTAACG/ACCAGC`	1	--	ut5¹		4	NS	376
--	rs41314707^1,2	F	34665329(+)	`CAGTGG/ACTGTG`	1	--	ng3¹		2	NS	188
--	rs41315517^1,2	F	34665500(+)	`TGTAAT/GATTAA`	1	--	ng3¹		1	NS	94

About this table

HapMap Linkage Disequilibrium images for KCNE2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603796

UniProtKB/Swiss-Prot: KCNE2_HUMAN, Q9Y6J6

Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6) [MIM:603796]. Long QT

syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic

ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional

stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing

potassium currents

Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4)

[MIM:611493]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a

small subgroup of patients. It is characterized by disorganized atrial electrical activity,

progressive deterioration of atrial electromechanical function and ineffective pumping of blood

into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and

congestive heart failure

7 Novoseek disease relationships for KCNE2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
long qt syndrome	93.45	14	10219239 (1), 11289718 (1), 14760488 (1), 18603586 (1) (see all 11)
romano-ward syndrome	87.66	3	10898405 (1), 18752142 (1), 10973849 (1)
atrial fibrillation, familial	85.36	1	15368194 (1)
death sudden	74.18	2	11289718 (1), 14642002 (1)
arrhythmia	73.54	16	18006462 (2), 18221016 (1), 11468227 (1), 19219384 (1) (see all 9)
ventricular fibrillation	54.14	1	10219239 (1)
heart diseases	35.32	1	14642002 (1)

About this table

1 PharmGKB disease relationship for KCNE2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Long QT Syndrome	CO FA GN	11101505 10219239 10984545

About this table

GeneTests: KCNE2

Romano-Ward Syndrome

Human Gene Mutation Database: KCNE2
Genetic Association Database: KCNE2
Human Genome Epidemiology Navigator: KCNE2 (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for KCNE2 gene (see all 99 ):

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PubMed id 10219239)^{1, 2, 3, 4, 7} Abbott G.W.... Goldstein S.A.N. (1999)
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. (PubMed id 11101505)^{3, 4, 7} Tinel N.... Barhanin J. (2000)
Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics. (PubMed id 12185453)^{1, 3, 4} Isbrandt D....Schulze-Bahr E. (2002)
Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. (PubMed id 15368194)^{1, 3, 4} Yang Y....Chen Y. (2004)
Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. (PubMed id 14760488)^{1, 3, 6} Paulussen A.D....Aerssens J. (2004)
Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. (PubMed id 14661677)^{1, 3, 6} Ackerman M.J....Curran M.E. (2003)
Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. (PubMed id 11874988)^{1, 3, 4} Abbott G.W. and Goldstein S.A.N. (2002)
Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. (PubMed id 15746444)^{1, 3, 6} Pfeufer A....Kaab S. (2005)
Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome. (PubMed id 11289718)^{1, 3, 6} Itoh T....Tanaka T. (2001)
Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. (PubMed id 15840476)^{3, 6} Tester D.J....Ackerman M.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9992	HGNC: 6242	AceView: KCNE2	Ensembl:ENSG00000159197	euGenes: HUgn9992
ECgene: KCNE2	H-InvDB: KCNE2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
LQTSdb	http://Www.ssi.dk/en/forskning/lqtsdb/kcne2.htm
GeneReviews	http://www.genetests.org/query?gene=KCNE2

Licensable Technologies for KCNE2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNE2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNE2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNE2		Antibodies for KCNE2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNE2		Browse small molecules at Sigma-Aldrich
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Antibodies for KCNE2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KCNE2 Gene at Home site.
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KCNE2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for KCNE2

Summaries
for KCNE2

Genomic Location
for KCNE2

Proteins
for KCNE2

Protein Domains/
Families
for KCNE2

Gene Function
for KCNE2

Pathways & Interactions
for KCNE2

Drugs & Compounds
for KCNE2

Transcripts
for KCNE2

Expression
for KCNE2

Orthologs
for KCNE2

Paralogs
for KCNE2

SNPs/Variants
for KCNE2

Disorders & Mutations
for KCNE2

Medical News
for KCNE2

Publications
for KCNE2

Search for KCNE2

Genome Databases showing KCNE2

Other Databases showing KCNE2

Specialized Databases showing KCNE2

Licensable Technologies
for KCNE2

Services
for KCNE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNE2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor KCNE2

Summariesfor KCNE2

Genomic Locationfor KCNE2

Proteinsfor KCNE2

Protein Domains/Familiesfor KCNE2

Gene Functionfor KCNE2

Pathways & Interactionsfor KCNE2

Drugs & Compoundsfor KCNE2

Transcriptsfor KCNE2

Expression for KCNE2

Orthologsfor KCNE2

Paralogsfor KCNE2

SNPs/Variantsfor KCNE2

Disorders & Mutationsfor KCNE2

Medical Newsfor KCNE2

Publicationsfor KCNE2

Search for KCNE2

Genome Databases showing KCNE2

Other Databases showing KCNE2

Specialized Databases showing KCNE2

Licensable Technologiesfor KCNE2

Servicesfor KCNE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNE2

Summaries
for KCNE2

Genomic Location
for KCNE2

Proteins
for KCNE2

Protein Domains/
Families
for KCNE2

Gene Function
for KCNE2

Pathways & Interactions
for KCNE2

Drugs & Compounds
for KCNE2

Transcripts
for KCNE2

Expression
for KCNE2

Orthologs
for KCNE2

Paralogs
for KCNE2

SNPs/Variants
for KCNE2

Disorders & Mutations
for KCNE2

Medical News
for KCNE2

Publications
for KCNE2

Licensable Technologies
for KCNE2

Services
for KCNE2