Aliases for KCND3 Gene
External Ids for KCND3 Gene
Previous HGNC Symbols for KCND3 Gene
Previous GeneCards Identifiers for KCND3 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCND3 Gene
KCND3 (Potassium Channel, Voltage Gated Shal Related Subfamily D, Member 3) is a Protein Coding gene. Diseases associated with KCND3 include spinocerebellar ataxia 19 and episodic ataxia/myokymia syndrome. Among its related pathways are Transmission across Chemical Synapses and Antiarrhythmic Pathway, Pharmacodynamics. GO annotations related to this gene include ion channel binding and A-type (transient outward) potassium channel activity. An important paralog of this gene is KCNA10.
UniProtKB/Swiss-Prot for KCND3 Gene
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.