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KCND3 Gene

protein-coding GIFtS: 68

GC01M112114

potassium voltage-gated channel, Shal-related subfamily, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KCND3L ^², ⁵
KCND3S ^², ⁵
KSHIVB ^¹, ²
KV4.3 ^²
Kv4.3 ^¹
MGC142035 ^²
MGC142037 ^²
OTTHUMP00000013771 ^²
OTTHUMP00000013772 ^²
OTTHUMP00000063948 ^²

Descriptions
Voltage-gated potassium channel subunit Kv4.3 ^³
potassium ionic channel Kv4.3 ^²
potassium voltage-gated channel, Shal-related subfamily, member 3 ^²
sha1-related potassium channel Kv4.3 ^²
voltage-gated K+ channel ^²
voltage-gated potassium channel Kv4.3 ^²

External Ids
HGNC: 6239¹
Entrez Gene: 3752²
UniProtKB: Q9UK17³
Ensembl: ENSG00000171385⁷

Search outside databases for aliases for KCND3 gene

Previous GC identifers: GC01M112734 GC01M111189 GC01M111420 GC01M111617 GC01M112030

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCND3:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four

sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in

Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the

potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated

A-type potassium ion channels and are prominent in the repolarization phase of the action

potential. This member includes two isoforms with different sizes, which are encoded by

alternatively spliced transcript variants of this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCND3_HUMAN, Q9UK17

Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium

channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel

properties are modulated by interactions with other alpha subunits and with regulatory subunits

Gene Wiki entry for KCND3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCND3 gene

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

KCND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M112114: (about GC identifiers)

Start:	112,114,807 bp from pter
End:	112,333,300 bp from pter
Size:	218,494 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCND3_HUMAN, Q9UK17 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily D member 3

Size: 655 amino acids; 73451 Da

Subunit: Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory

subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with KCNE1, KCNE2, SCN1B and

KCNAB1 and DLG1

Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma (By

similarity)

PDB structure from and Proteopedia :

1S1G (3D)

2NZ0 (3D)

Secondary accessions: O60576 O60577 Q5T0M0 Q9UH85 Q9UH86 Q9UK16

Alternative splicing: 2 isoforms: Q9UK17-1 Q9UK17-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004971.2 NP_751948.1

ENSEMBL proteins:

ENSP00000306923 ENSP00000358711 ENSP00000319591

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kv4.3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	8734615
GO:0016020	membrane	IEA	--
GO:0043005	neuron projection	IEA	--
GO:0043025	cell soma	IEA	--

About this table

Antibodies for KCND3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCND3
	Sigma-Aldrich Antibodies for KCND3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kv4.3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCND3

Assays for KCND3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UK17

ProtoNet protein and cluster: Q9UK17

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003975 Shal voltage-gated K+ channel family signature

IPB004056 Kv4.3 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCND3_HUMAN, Q9UK17

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. D (Shal) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCND3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCND3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004980

Applied Biosystems Silencer® siRNAs for KCND3

Sigma-Aldrich siRNA and siRNA Panels for KCND3

Sigma-Aldrich shRNA Panels and shRNA for KCND3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004980
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004980
untagged cDNA clones in CMV expression vector (see all 3): NM_004980

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004980

UniProtKB/Swiss-Prot: KCND3_HUMAN, Q9UK17

Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium

channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel

properties are modulated by interactions with other alpha subunits and with regulatory subunits

Genatlas biochemistry entry for KCND3:

potassium voltage-gated channel,Shal-related family member 3,expressed in the cerebral cortex

(mouse Kv8.1 homolog),inhibiting expression of Shaw channels

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnd3):

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0005250	A-type (transient outward) potassium channel activity	TAS	8734615
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for KCND3

5/51 Interacting proteins for KCND3 (ENSP00000319591³) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNIP2	ENSP00000347877³	STRING (score=.999)
KCNE2	ENSP00000290310³	STRING (score=.995)
KCNH2	ENSP00000262186³	STRING (score=.978)
KCNE1	ENSP00000337255³	STRING (score=.977)
KCNJ5	ENSP00000339960³	STRING (score=.97)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	8734615

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCND3

Browse Small Molecules at Sigma-Aldrich

Compounds for KCND3 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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3 Novoseek chemical compound relationships for KCND3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	64.43	9	10325966 (2), 9490854 (1), 8051145 (1), 15563876 (1) (see all 7)
calcium	10.96	3	15743891 (1), 18045167 (1)
lipid	0.00	2	1371017 (1), 7696252 (1)

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1 PharmGKB drug compound relationship for KCND3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA	8831489

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCND3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCND3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004980

Sigma-Aldrich siRNA and siRNA Panels for KCND3

Sigma-Aldrich shRNA Panels and shRNA for KCND3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004980 NM_172198

REFSEQ mRNAs for KCND3 gene (2 alternative transcripts):

NM_004980.3 NM_172198.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004980 NM_172198

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004980
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004980
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_004980

Additional cDNA sequence:

AF048712.1 AF048713.1 AF120491.1 AF187963.1 AF187964.1 AF205856.1 AF205857.1 AY863198.1

BC113475.1 BC113477.1 BC143390.1

3 DOTS entries:

DT.91801062 DT.91801061 DT.65286287

12 AceView cDNA sequences:

NM_004980 BX096687 NM_172198 AF187963 AF187964 BI033106 AF205856 AF120491

AF048712 AF048713 AF205857 BQ340099

highest scoring ESTs for KCND3:

AF048713 AF120491 AF048712 AF187963 AF187964 AF205856 AF205857 BI033106 BX096687 NM_004980

Unigene Cluster for KCND3:

Potassium voltage-gated channel, Shal-related subfamily, member 3

Hs.666367 [show with all ESTs]

Unigene Representative Sequence: AF120491

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KCND3

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:							-		-
SP2:							-		-								-
SP3:

About this scheme

ECgene alternative splicing isoforms for KCND3

3 Ensembl transcripts including schematic representations:

ENST00000302127 ENST00000369697 ENST00000315987

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCND3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCND3

¹ / ² / ³

11 probe-sets matching KCND3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31533_s_at²^{, 3}	U95-A	1	1.00	1.00	0.67	0.76	AF048713	0.80	1.00	0.91	1
33587_f_at²^{, 3}	U95-A	1	1.00	1.00	0.69	1.04	AI369146	0.40	1.00	0.76	1
39266_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.24	AF070632	0.20	1.00	0.72	1
215014_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
213832_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
211827_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF187964	0.60	1.00	0.82	1
211301_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF120491	0.80	1.00	0.91	1
215014_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213832_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211827_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211301_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCND3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGGTGGGTG

SOURCE GeneReport for Unigene cluster: Hs.666367
Expression variation in blood from EXPOLDB for KCND3
UniProtKB/Swiss-Prot: KCND3_HUMAN, Q9UK17
Tissue specificity: Highly expressed in heart and brain, in particular in cortex, cerebellum,
amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and
pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar
levels in brain, skeletal muscle and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCND3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCND3¹	--	potassium voltage-gated channel, Shal-related subfamily, more	93.74(n) 99.24(a)	403758 XM_845974.1 XP_851067.1
chimpanzee (Pan troglodytes)	KCND3¹	--	potassium voltage-gated channel, Shal-related subfamily, more	98.27(n) 97.56(a)	744303 XM_001158370.1 XP_001158370.1
rat (Rattus norvegicus)	Kcnd3¹	--	potassium voltage gated channel, Shal-related family, more	91.67(n) 99.06(a)	65195 NM_031739.1 NP_113927.1
mouse (Mus musculus)	Kcnd3^{1, 5}	3⁵	potassium voltage-gated channel, Shal-related family, more^{1, 5}	91.35(n)¹ 99.39(a)¹	56543¹ NM_019931.1¹ NP_064315.1¹ AF107781⁵ AF107782⁵ (see all 17)
chicken (Gallus gallus)	KCND3¹	--	potassium voltage-gated channel, Shal-related subfamily, more	82.6(n) 94.96(a)	374228 NM_204326.1 NP_989657.1

About this table Species with no ortholog for KCND3

ENSEMBL Gene Tree for KCND3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCND3 gene

KCND2² KCND1² KCNA7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1291 NCBI SNPs in KCND3 are shown (see all 1291 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 628)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs12033257^1,2	C,F,H	112120007(+)	`GATGCA/GGTATC`	2	--	ut3¹ ese³		11	EU EA WA NA	972
	rs2289723^1,2	C,F,H,O	112326497(-)	`CTCCCG/AGAGAT`	2	P/P	syn¹ ese³		10	EA NA EU WA	2506
	rs12720446^1,2	F,H	112326755(-)	`CAGGAT/CGAGCT`	2	D/D	syn¹		5	EU EA WA	798
	rs17221819^1,2	C,F	112326608(-)	`GACCCC/TGAGGT`	2	P/P	syn¹ ese³		2	NA	458
	rs17215423^1,2	C,F	112326203(-)	`TACTCG/CGTGGC`	2	S/S	syn¹ ese³		2	NA	448
	rs17215458^1,2	C	112124883(-)	`GCATAC/TCTGCA`	2	Y/Y	syn¹		2	NA	456
	rs2365670^1,2	A,C,F,H,O	112164402(+)	`TGCTGG/TTTCTA`	2	--	int¹		7	EU EA WA NA	548
	rs1538389^1,2	A,C,F,H,O	112128667(-)	`TGACTG/AGTTTG`	2	--	int¹		4	EU EA WA	418
	rs672757^1,2	A,C,F,H,O	112148779(+)	`GGAGAA/GCATGA`	2	--	int¹		12	EU EA WA NA	1046
	rs2798334^1,2	A,C,F,H,O	112238867(+)	`CCATCC/TGGTCC`	2	--	int¹		7	EU EA WA NA	558

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HapMap Linkage Disequilibrium images for KCND3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605411

2 Novoseek disease relationships for KCND3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
long qt syndrome	49.92	7	15563876 (2), 10942109 (1), 18052691 (1)
arrhythmia	9.43	2	10942109 (1), 18855674 (1)

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Genetic Association Database: KCND3
Human Genome Epidemiology Navigator: KCND3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/81 PubMed articles for KCND3 gene (see all 81 ):

Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome. (PubMed id 15563876)^{1, 3, 6} Frank-Hansen R....Christiansen M. (2005)
Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3. (PubMed id 10942109)^{1, 2, 3} Postma A.V....Mannens M.M. (2000)
Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)^{1, 3, 4} Isbrandt D.... Pongs O. (2000)
Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. (PubMed id 19213956)^{3, 4} El-Haou S.... Hatem S.N. (2009)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. (PubMed id 14980207)^{3, 4} Scannevin R.H.... Rhodes K.J. (2004)
Modulation of Kv4.3 current by accessory subunits. (PubMed id 12297301)^{3, 4} Deschenes I. and Tomaselli G.F. (2002)
Cloning and expression of the human Kv4.3 potassium channel. (PubMed id 10200233)^{3, 4} Dilks D.... Numann R. (1999)
Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. (PubMed id 9843794)^{3, 4} Kong W.... Tomaselli G.F. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3752	HGNC: 6239	AceView: KCND3	Ensembl:ENSG00000171385	euGenes: HUgn3752
ECgene: KCND3	H-InvDB: KCND3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KCND3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KCND3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCND3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCND3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCND3		Antibodies for KCND3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCND3		Browse small molecules at Sigma-Aldrich
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GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KCND3 Gene at Home site.
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KCND3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for KCND3

Summaries
for KCND3

Genomic Location
for KCND3

Proteins
for KCND3

Protein Domains/
Families
for KCND3

Gene Function
for KCND3

Pathways & Interactions
for KCND3

Drugs & Compounds
for KCND3

Transcripts
for KCND3

Expression
for KCND3

Orthologs
for KCND3

Paralogs
for KCND3

SNPs/Variants
for KCND3

Disorders & Mutations
for KCND3

Medical News
for KCND3

Publications
for KCND3

Search for KCND3

Genome Databases showing KCND3

Other Databases showing KCND3

Specialized Databases showing KCND3

Licensable Technologies
for KCND3

Services
for KCND3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCND3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor KCND3

Summariesfor KCND3

Genomic Locationfor KCND3

Proteinsfor KCND3

Protein Domains/Familiesfor KCND3

Gene Functionfor KCND3

Pathways & Interactionsfor KCND3

Drugs & Compoundsfor KCND3

Transcriptsfor KCND3

Expression for KCND3

Orthologsfor KCND3

Paralogsfor KCND3

SNPs/Variantsfor KCND3

Disorders & Mutationsfor KCND3

Medical Newsfor KCND3

Publicationsfor KCND3

Search for KCND3

Genome Databases showing KCND3

Other Databases showing KCND3

Specialized Databases showing KCND3

Licensable Technologiesfor KCND3

Servicesfor KCND3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCND3

Summaries
for KCND3

Genomic Location
for KCND3

Proteins
for KCND3

Protein Domains/
Families
for KCND3

Gene Function
for KCND3

Pathways & Interactions
for KCND3

Drugs & Compounds
for KCND3

Transcripts
for KCND3

Expression
for KCND3

Orthologs
for KCND3

Paralogs
for KCND3

SNPs/Variants
for KCND3

Disorders & Mutations
for KCND3

Medical News
for KCND3

Publications
for KCND3

Licensable Technologies
for KCND3

Services
for KCND3