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KCND2 Gene

protein-coding GIFtS: 65

GC07P119700

potassium voltage-gated channel, Shal-related subfamily, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1044 ^¹, ², ³, ⁵
KV4.2 ^²
Kv4.2 ^¹
MGC119702 ^²
MGC119703 ^²
RK5 ^¹, ²

Descriptions
Voltage-gated potassium channel subunit Kv4.2 ^³
potassium voltage-gated channel, Shal-related subfamily, member 2 ^²
voltage-gated potassium channel Kv4.2 ^²
voltage-sensitive potassium channel ^²

External Ids
HGNC: 6238¹
Entrez Gene: 3751²
UniProtKB: Q9NZV8³
Ensembl: ENSG00000184408⁷

Search outside databases for aliases for KCND2 gene

Previous GC identifers: GC07P118391 GC07P119454 GC07P119468 GC07P119507

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCND2:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four

sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in

Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the

potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated

A-type potassium ion channels and are prominent in the repolarization phase of the action

potential. This member mediates a rapidly inactivating, A-type outward potassium current which is

not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8

Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium

channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel

properties are modulated by interactions with other alpha subunits and with regulatory subunits

Gene Wiki entry for KCND2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCND2 gene

Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31

KCND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P119700: (about GC identifiers)

Start:	119,700,958 bp from pter
End:	120,177,623 bp from pter
Size:	476,666 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 119,308,832-119,785,474

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily D member 2

Size: 630 amino acids; 70537 Da

Subunit: Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and FREQ

(By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2,

KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2.

The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with

FLNA, FLNC and DPP10

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.

Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably

enhances cell surface expression

Secondary accessions: O95012 O95021 Q2TBD3 Q9UBY7 Q9UN98 Q9UNH9

Post-translational modifications:

Phosphorylated on serine and threonine residues (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036413.1

ENSEMBL proteins:

ENSP00000333496

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCND2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kv4.2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0009986	cell surface	IDA	12493773
GO:0016021	integral to membrane	IEA	--
GO:0042995	cell projection	IEA	--

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Antibodies for KCND2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCND2
	Sigma-Aldrich Antibodies for KCND2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kv4.2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCND2

Assays for KCND2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NZV8

ProtoNet protein and cluster: Q9NZV8

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003975 Shal voltage-gated K+ channel family signature

IPB004055 Kv4.2 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. D (Shal) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012281

Applied Biosystems Silencer® siRNAs for KCND2

Sigma-Aldrich siRNA and siRNA Panels for KCND2

Sigma-Aldrich shRNA Panels and shRNA for KCND2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of KCND2

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012281
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012281
untagged cDNA clone in CMV expression vector: NM_012281

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012281

UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8

Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium

channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel

properties are modulated by interactions with other alpha subunits and with regulatory subunits

Genatlas biochemistry entry for KCND2:

potassium voltage-gated channel,Shal-related family member 2,expressed in brain but not in

heart,mediating a rapidly-inactivating transient voltage-sensitive K+,current,rat Kv4.2 homolog

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnd2):

behavior/neurological

nervous system

touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	NAS	11102480
GO:0005515	protein binding	NAS	11102480
GO:0008270	zinc ion binding	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCND2

5/19 Interacting proteins for KCND2 (ENSP00000333496³ Q9NZV8¹) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNIP1	Q9NZI2¹	EBI-1646745, EBI-2120635
KCNIP2	ENSP00000347877³	STRING (score=.998)
KCNIP4	ENSP00000346408³	STRING (score=.99)
IRX5	ENSP00000316250³	STRING (score=.981)
DLG4	ENSP00000293813³	STRING (score=.957)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001508	regulation of action potential	TAS	11102480
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	IEA	--
GO:0007268	synaptic transmission	TAS	11102480

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCND2 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

1 Novoseek chemical compound relationship for KCND2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	56.39	7	16412265 (1), 15563876 (1), 10935529 (1), 12586336 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012281

Sigma-Aldrich siRNA and siRNA Panels for KCND2

Sigma-Aldrich shRNA Panels and shRNA for KCND2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012281

REFSEQ mRNAs for KCND2 gene:

NM_012281.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012281

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012281
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012281
                                 untagged cDNA clone in CMV expression vector: NM_012281

Additional cDNA sequence:

AB028967.1 AF121104.1 AJ010969.1 AK307139.1 BC110449.1 BC110450.1

1 DOTS entry:

DT.437263

13 AceView cDNA sequences:

AJ010969 NM_012281 AB028967 CD654252 BF792906 C15176 BG205115 D54065

AF121104 C15006 BG196870 BG194345 M85950

highest scoring ESTs for KCND2:

AA427449 AA430701 BF060891 BF792906 BG196870 BG205115 BX118783 C15176 D54065 T05090

Unigene Cluster for KCND2:

Potassium voltage-gated channel, Shal-related subfamily, member 2

Hs.654739 [show with all ESTs]

Unigene Representative Sequence: AB028967

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000331113

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCND2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCND2

¹ / ² / ³

3 probe-sets matching KCND2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32873_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AC004888	0.20	1.00	0.72	1
207103_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012281	0.60	1.00	0.82	1
207103_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTGAACAGG

SOURCE GeneReport for Unigene cluster: Hs.654739
Expression variation in blood from EXPOLDB for KCND2
UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8
Tissue specificity: Highly expressed throughout the brain. Expression is very low or absent in
other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCND2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCND2¹	--	potassium voltage-gated channel, Shal-related subfamily, more	86.72(n) 97.94(a)	491424 XM_861154.1 XP_866247.1
chimpanzee (Pan troglodytes)	KCND2¹	--	potassium voltage-gated channel, Shal-related subfamily, more	99.74(n) 100(a)	472489 XM_527864.2 XP_527864.2
cow (Bos taurus)	KCND2¹	--	potassium voltage-gated channel, Shal-related subfamily, more	91.69(n) 99.21(a)	540416 XM_001251641.1 XP_001251642.1
rat (Rattus norvegicus)	Kcnd2¹	--	potassium voltage gated channel, Shal-related family, more	89.05(n) 99.21(a)	65180 NM_031730.2 NP_113918.2
mouse (Mus musculus)	Kcnd2^{1, 5}	6 (7.20 cM)⁵	potassium voltage-gated channel, Shal-related family, more^{1, 5}	88.89(n)¹ 99.05(a)¹	16508¹ NM_019697.3¹ NP_062671.1¹ AB045326⁵ AB093280⁵ (see all 16)

About this table Species with no ortholog for KCND2

ENSEMBL Gene Tree for KCND2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCND2 gene

KCND1² KCND3² KCNA7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1896 NCBI SNPs in KCND2 are shown (see all 1896 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 549)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs727228^1,2	A,C,F,H,O	120176884(-)	`TTACTA/TGAAAA`	1	--	ut3¹		17	MN EA NA EU WA	1600
	rs3814463^1,2	A,C,F,H	119700085(-)	`AAAGCT/CCCGAC`	1	--	ng5¹		4	EU EA WA	412
	rs3735340^1,2	A,C,F,H	119701215(+)	`CAGACA/GCAGAG`	1	--	ut5¹		4	EU EA WA	412
	rs12539187^1,2	C,F,H	120176289(+)	`TCTAAC/TGTCTT`	1	--	ut3¹		5	EU EA WA NA	510
	rs11764789^1,2	C,H	120176326(+)	`TGGATA/GTATCA`	1	--	ut3¹		4	EU EA WA	418
--	rs13238793^1,2	H	120175981(+)	`CATTCG/ATAGAA`	1	--	ut3¹		4	EU EA WA	420
	rs13225585^1,2	H	120175757(+)	`CATGGT/GGGGCT`	1	--	ut3¹		4	EU EA WA	420
	rs13238427^1,2	H	120175926(+)	`TCAGGA/TTTTTT`	1	--	ut3¹		4	EU EA WA	420
	rs13238785^1,2	H	120175950(+)	`TTCCAG/CATCCT`	1	--	ut3¹		4	EU EA WA	420
	rs13225617^1,2	H	120175840(+)	`ATAGTT/CCAGTA`	1	--	ut3¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for KCND2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605410

2 Novoseek disease relationships for KCND2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
long qt syndrome	46.23	5	15563876 (2), 10942109 (1)
arrhythmia	39.15	2	10942109 (1), 18855674 (1)

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Human Gene Mutation Database: KCND2
Genetic Association Database: KCND2
Human Genome Epidemiology Navigator: KCND2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/63 PubMed articles for KCND2 gene (see all 63 ):

Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. (PubMed id 10551270)^{1, 2, 3, 4} Zhu X.-R.... Pongs O. (1999)
Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome. (PubMed id 15563876)^{1, 3, 6} Frank-Hansen R....Christiansen M. (2005)
Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)^{1, 3, 4} Jerng H.H.... Pfaffinger P.J. (2004)
Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. (PubMed id 14623880)^{1, 3, 4} Kim L.A.... Goldstein S.A. (2004)
Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)^{1, 3, 4} Isbrandt D.... Pongs O. (2000)
Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. (PubMed id 19213956)^{3, 4} El-Haou S.... Hatem S.N. (2009)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. (PubMed id 14980207)^{3, 4} Scannevin R.H.... Rhodes K.J. (2004)
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. (PubMed id 14980201)^{3, 4} Kim L.A....Grigorieff N. (2004)
Protein-protein interactions of KChIP proteins and Kv4.2. (PubMed id 15358149)^{3, 4} Lin Y.-L.... Chang L.S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3751	HGNC: 6238	AceView: KCND2	Ensembl:ENSG00000184408	euGenes: HUgn3751
ECgene: KCND2	H-InvDB: KCND2

(According to HUGE)
About This Section

HUGE: KIAA1044

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCND2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCND2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCND2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCND2		Antibodies for KCND2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCND2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for KCND2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KCND2

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KCND2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for KCND2

Summaries
for KCND2

Genomic Location
for KCND2

Proteins
for KCND2

Protein Domains/
Families
for KCND2

Gene Function
for KCND2

Pathways & Interactions
for KCND2

Drugs & Compounds
for KCND2

Transcripts
for KCND2

Expression
for KCND2

Orthologs
for KCND2

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for KCND2

SNPs/Variants
for KCND2

Disorders & Mutations
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Medical News
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Services
for KCND2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCND2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor KCND2

Summariesfor KCND2

Genomic Locationfor KCND2

Proteinsfor KCND2

Protein Domains/Familiesfor KCND2

Gene Functionfor KCND2

Pathways & Interactionsfor KCND2

Drugs & Compoundsfor KCND2

Transcriptsfor KCND2

Expression for KCND2

Orthologsfor KCND2

Paralogsfor KCND2

SNPs/Variantsfor KCND2

Disorders & Mutationsfor KCND2

Medical Newsfor KCND2

Publicationsfor KCND2

Search for KCND2

Genome Databases showing KCND2

Other Databases showing KCND2

Specialized Databases showing KCND2

Licensable Technologiesfor KCND2

Servicesfor KCND2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCND2

Summaries
for KCND2

Genomic Location
for KCND2

Proteins
for KCND2

Protein Domains/
Families
for KCND2

Gene Function
for KCND2

Pathways & Interactions
for KCND2

Drugs & Compounds
for KCND2

Transcripts
for KCND2

Expression
for KCND2

Orthologs
for KCND2

Paralogs
for KCND2

SNPs/Variants
for KCND2

Disorders & Mutations
for KCND2

Medical News
for KCND2

Publications
for KCND2

Licensable Technologies
for KCND2

Services
for KCND2