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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCND2 Gene

protein-coding   GIFtS: 66
GCID: GC07P119913

potassium voltage-gated channel, Shal-related subfamily,...
 Explore 6 diseases affiliated with
KCND2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCND2    

Aliases
for KCND2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 21 2     KV4.22
KIAA10441 3 5     Potassium Voltage-Gated Channel Subfamily D Member 22
RK51 2     Voltage-Gated Potassium Channel Kv4.22
Voltage-Gated Potassium Channel Subunit Kv4.22 3     Voltage-Sensitive Potassium Channel2
Kv4.21     

External Ids:    HGNC: 62381   Entrez Gene: 37512   Ensembl: ENSG000001844087   OMIM: 6054105   UniProtKB: Q9NZV83   

Export aliases for KCND2 gene to outside databases

Previous GC identifers: GC07P118391 GC07P119454 GC07P119468 GC07P119507 GC07P119700 GC07P114276


Summaries
for KCND2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCND2:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,
voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are
prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type
outward potassium current which is not under the control of the N terminus as it is in Shaker channels. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute
to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other
alpha subunits and with regulatory subunits

summary for KCND2:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCND2


Genomic Views
for KCND2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCND2 gene promoter:
         AhR   CREB   AP-1   deltaCREB   Hand1   E47   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCND2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCND2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.31   HGNC cytogenetic band: 7q31

KCND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCND2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P119913:  view genomic region     (about GC identifiers)

Start:
 119,913,722 bp from pter      End:
 120,390,387 bp from pter
Size:
 476,666 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 119,308,832-119,785,474     

Proteins
for KCND2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily D member 2  
Size: 630 amino acids; 70537 Da
Subunit: Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By
similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably
part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four
KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Detected in dendrites
in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression
Sequence caution: Sequence=BAA82996.2; Type=Erroneous initiation;
Secondary accessions: O95012 O95021 Q2TBD3 Q9UBY7 Q9UN98 Q9UNH9

Explore the universe of human proteins at neXtProt for KCND2: NX_Q9NZV8

Post-translational modifications:

  • Phosphorylated on serine and threonine residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZV8

    • KCND2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036413.1  
    ENSEMBL proteins: 
     ENSP00000333496   ENSP00000415463  
    Reactome Protein details: Q9NZV8
    Human Recombinant Protein Products: 
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    Uscn Proteins for KCND2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ----
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0009986cell surface IDA12493773
    GO:0014069postsynaptic density ----


    KCND2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCND2

    Protein Domains /
    Families
    for KCND2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCND2 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR005821 Ion_trans_dom
     IPR024587 K_chnl_volt-dep_Kv4_C
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003975 K_chnl_volt-dep_Kv4

    Graphical View of Domain Structure for InterPro Entry Q9NZV8

    ProtoNet protein and cluster: Q9NZV8

    4 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003975 Shal voltage-gated K+ channel family signature
    IPB004055 Kv4.2 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily


    Function
    for KCND2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8
    Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute
    to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other
    alpha subunits and with regulatory subunits

         Genatlas biochemistry entry for KCND2:
    potassium voltage-gated channel,Shal-related family member 2,expressed in brain but not in heart,mediating a
    rapidly-inactivating transient voltage-sensitive K+,current,rat Kv4.2 homolog

    miRNA
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    hsa-miR-4307 hsa-miR-19b-2* hsa-miR-25 hsa-miR-3653 hsa-miR-519a hsa-miR-218 hsa-miR-186 hsa-miR-3148
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity NAS11102480
    GO:0005250A-type (transient outward) potassium channel activity IBA--
    GO:0005251NOT delayed rectifier potassium channel activity IBA--
    GO:0005267potassium channel activity ----


    KCND2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KCND2: Kcnd2tm1Ssot Kcnd2tm1Jmn
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnd2):
     behavior/neurological  integument  nervous system 

    KCND2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCND2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    		Voltage gated Potassium channels0.43
    2Synaptic transmission: ion currents
    		Synaptic transmission: ion currents1.00
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for KCND2
        Synaptic transmission- ion currents
    Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCND2
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCND2
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCND2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for KCND2 (Q9NZV81, 3 ENSP000003334964) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNIP1Q9NZI21, 3, ENSP000003953234EBI-1646745,EBI-2120635 I2D: score=4 STRING: ENSP00000395323
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    KCNIP2Q9NS613, ENSP000004200404I2D: score=3 STRING: ENSP00000420040
    DLG4P783523, ENSP000002938134I2D: score=2 STRING: ENSP00000293813
    KCNIP4Q6PIL63, ENSP000003989434I2D: score=1 STRING: ENSP00000398943
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential TAS11102480
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0051291protein heterooligomerization ----
    GO:0071805potassium ion transmembrane transport ----


    KCND2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCND2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCND2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCND2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCND2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    3 DrugBank Compounds for KCND2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmitriptylineAmitriprolidine (see all 7)50-48-6targetinhibitor9781919
    DisopyramideDisopiramida [INN-Spanish] (see all 4)3737-09-5targetinhibitor9781919
    Imipramine-- 50-49-7targetinhibitor9781919

    2 Novoseek chemical compound relationships for KCND2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 60.1 9 16412265 (1), 15563876 (1), 19453640 (1), 10935529 (1) (see all 8)
    flecainide 53.5 2 9093524 (2)

    Search CenterWatch for drugs/clinical trials and news about KCND2 

    Transcripts
    for KCND2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCND2 gene: 
    NM_012281.2  

    Unigene Cluster for KCND2:

    Potassium voltage-gated channel, Shal-related subfamily, member 2
    Hs.654739  [show with all ESTs]
    Unigene Representative Sequence: AB028967
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331113(uc003vjj.1) ENST00000425288 ENST00000473190

    miRNA
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    hsa-miR-4307 hsa-miR-19b-2* hsa-miR-25 hsa-miR-3653 hsa-miR-519a hsa-miR-218 hsa-miR-186 hsa-miR-3148
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB028967.1 AF121104.1 AJ010969.1 AK307139.1 BC110449.1 BC110450.1 

    1 DOTS entry:

    DT.437263 

    13 AceView cDNA sequences:

    NM_012281 AJ010969 AB028967 CD654252 BF792906 C15176 D54065 BG205115 
    AF121104 C15006 BG194345 BG196870 M85950 

    GeneLoc Exon Structure


    Expression
    for KCND2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGAACAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCND2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneZeugopod Epiphyseal EndBone
    BrainMedulla OblongataBrain
    LimbAutopodLimb
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCND2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCND2

    SOURCE GeneReport for Unigene cluster: Hs.654739

    UniProtKB/Swiss-Prot: KCND2_HUMAN, Q9NZV8
    Tissue specificity: Highly expressed throughout the brain. Expression is very low or absent in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including KCND2: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for KCND2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCND2 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCND21 potassium voltage-gated channel, Shal-related subfamily, more 82.59(n)
    93.81(a)    		   374143  NM_204279.1  NP_989610.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCND26
    		 --
    		 92(a)
    		 1 ↔ 1
    		 5(62965506-62966621)
    zebrafish
    (Danio rerio)    		 Actinopterygii kcnd21 potassium voltage-gated channel, Shal-related subfamily, more 71.3(n)
    80.99(a)    		   570188  NM_001082867.2  NP_001076336.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shal1 , 3 potassium ion transport voltage-gated
    potassium more3
    Shaker cognate l1    		 72(a)3
    64.03(n)1
    69.62(a)1    		   76B73
    401291  NM_001104176.11  NP_001097646.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y73B6BL.193
    shl-11    		 Protein SHL-11 64(a)3
    60.08(n)1
    67.01(a)1    		   IV(6378470-6384170)3
    1774001  NM_068574.21  NP_500975.11 


    ENSEMBL Gene Tree for KCND2 (if available)
    TreeFam Gene Tree for KCND2 (if available) 

    Paralogs
    for KCND2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCND2 gene
    KCNA62  KCNA22  KCNC22  KCNC42  KCND12  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCND32  KCNA32  KCNA102  
    18/19 SIMAP similar genes for KCND2 using alignment to 4 protein entries:     KCND2_HUMAN (see all proteins) (see all similar genes):
    KCND3    KCND1    KCNB1    KCNA1    KCNS3    KCNA10
    KCNA5    KCNB2    KCNF1    KCNA3    KCNG1    KCNA7
    KCNA2    KCNC1    KCNV1    KCNA6    KCNG4    KCNS1

    KCND2 for paralogs           About GeneDecksing



    Genomic Variants
    for KCND2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7151 NCBI SNPs in KCND2 are shown (see all 7151)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1403660861,2
    		--119911752(+) AAACTG/TAAATG 1 -- us2k10--------
    rs1835193501,2
    		--119911959(+) TTTTCA/TAGGTT 1 -- us2k10--------
    rs1454274281,2
    		--119912264(+) TAGTAC/TATGTC 1 -- us2k10--------
    rs1128944861,2
    		--119912398(+) GATTTG/AACTTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1166401001,2
    		C,F,--119912440(+) TGTTAC/AGTTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs770930461,2
    		F,--119912671(+) CTCCAC/TATCCC 1 -- us2k11Minor allele frequency- T:0.26WA 118
    rs1891754561,2
    		--119912678(+) TCCCTC/GTTATT 1 -- us2k10--------
    rs1410752251,2
    		--119912711(+) TGTGTC/GAAGAC 1 -- us2k10--------
    rs1811126001,2
    		--119912750(+) GGCAAC/GTTGGA 1 -- us2k10--------
    rs1456487451,2
    		--119912751(+) GCAAGC/TTGGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCND2 (119913722 - 120163722 bp, first 250kb of KCND2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for KCND2
         3 CNVs: 52071 52072 10209
    Human Gene Mutation Database (HGMD): KCND2

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    Disorders / Diseases
    for KCND2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCND2 for disorders           About GeneDecksing

    OMIM gene information: 605410    OMIM disorders: --

    6 diseases for KCND2:    About MalaCards
    long qt syndrome    temporal lobe epilepsy    neuronitis    myocardial infarction
    hermaphroditism    seizures

    1 disease from the University of Copenhagen DISEASES database for KCND2:
    Long QT syndrome

    2 Novoseek disease relationships for KCND2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    long qt syndrome 44.4 5 15563876 (2), 10942109 (1)
    arrhythmia 37.4 2 10942109 (1), 18855674 (1)

    Genetic Association Database (GAD): KCND2
    Human Genome Epidemiology (HuGE) Navigator: KCND2 (6 documents)

    Export disorders for KCND2 gene to outside databases

    Publications
    for KCND2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCND2 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with KCND2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. (PubMed id 10551270)1, 2, 3, 9 Zhu X.-R.... Pongs O. (1999)
    2. Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome. (PubMed id 15563876)1, 4, 9 Frank-Hansen R....Christiansen M. (2005)
    3. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)1, 2, 9 Jerng H.H.... Pfaffinger P.J. (2004)
    4. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. (PubMed id 14623880)1, 2, 9 Kim L.A.... Goldstein S.A. (2004)
    5. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)1, 2, 9 Isbrandt D.... Pongs O. (2000)
    6. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. (PubMed id 19213956)1, 2 El-Haou S.... Hatem S.N. (2009)
    7. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    8. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. (PubMed id 14980201)1, 2 Kim L.A....Grigorieff N. (2004)
    9. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. (PubMed id 14980207)1, 2 Scannevin R.H.... Rhodes K.J. (2004)
    10. Protein-protein interactions of KChIP proteins and Kv4.2. (PubMed id 15358149)1, 2 Lin Y.-L.... Chang L.S. (2004)

    External Searches for KCND2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCND2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3751 HGNC: 6238 AceView: KCND2 Ensembl:ENSG00000184408 euGenes: HUgn3751
    ECgene: KCND2 H-InvDB: KCND2

    Other Databases showing KCND2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1044

    Specialized Databases showing KCND2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCND2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCND2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCND2 gene:
    Search GeneIP for patents involving KCND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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