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Aliases & Descriptions for KCND1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KV4.1 2 | | Kv4.1 1 | | OTTHUMP00000025805 2 |
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv4.1 3 | potassium voltage-gated channel, Shal-related subfamily, member 1 2 | | shal-type potassium channel 2 | | voltage-gated potassium channel Kv4.1 2 |
|
| | Search outside databases for aliases for KCND1 genePrevious GC identifers: GC0XM047621 GC0XM047079 GC0XM047864 GC0XM048574 |
Summaries for KCND1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCND1: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq] UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunitsGene Wiki entry for KCND1 |
Genomic Location for KCND1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCND1 gene 
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23KCND1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048703:
(about GC identifiers)
Start:
|
48,703,583 bp from pter |
End:
|
48,713,195 bp from pter |
Size:
|
9,613 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_079573.3
| Proteins for KCND1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily D member 1 Size: 647 amino acids; 71330 Da
Subunit: Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O75671REFSEQ proteins: NP_004970.3
ENSEMBL proteins: ENSP00000218176 ENSP00000365660
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCND1: Assays for KCND1: | Protein
Domains/ Families for KCND1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NSA2
ProtoNet protein and cluster: Q9NSA2 4 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003975 Shal voltage-gated K+ channel family signature IPB004054 Kv4.1 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. D (Shal) subfamily | Gene Function for KCND1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004979
Applied Biosystems Silencer® siRNAs for KCND1
Sigma-Aldrich siRNA and siRNA Panels for KCND1  Sigma-Aldrich shRNA Panels and shRNA for KCND1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004979                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004979                                  untagged cDNA clone in CMV expression vector: NM_004979 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004979
UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunitsGenatlas biochemistry entry for KCND1:potassium voltage-gated channel,Shal-related family member 1,expressed in fetal heart,infant brain,colon5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
NAS | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCND1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for KCND1 (ENSP000002181763) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
NAS | -- | About this table
|
Drugs & Compounds for KCND1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCND1 available from Tocris Bioscience About this table
|
Transcripts for KCND1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004979
Sigma-Aldrich siRNA and siRNA Panels for KCND1  Sigma-Aldrich shRNA Panels and shRNA for KCND1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004979 REFSEQ mRNAs for KCND1 gene: NM_004979.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004979               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004979                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004979                                  untagged cDNA clone in CMV expression vector: NM_004979  Additional cDNA sequence: AB021865.1 AF166003.1 AJ005898.1 AK315092.1 BC045659.1 2 DOTS entries: DT.442563 DT.99930272 24/26 AceView cDNA sequences (see all 26
):F03868 T35424 AK094431 AL120075 NM_004979 AJ005898 F07466 Z38762 AF166003 F05846 AI150825 BC045659 BX280616 AB021865 Z40519 BG194738 Z44902 BG181761 AI818239 AI936041 R16330 R41406 R61454 W02729
highest scoring ESTs for KCND1:AJ005898 AB021865 AF166003 AL120075 BC045659 AI150825 AI694424 AK094431 BG181761 BG194738 Unigene Cluster for KCND1: Potassium voltage-gated channel, Shal-related subfamily, member 1 Hs.55276 [show with all ESTs]Unigene Representative Sequence: BC045659
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KCND1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | |
| SP1: | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KCND1
2 Ensembl transcripts including schematic representations: ENST00000218176
ENST00000376477
|
Expression for KCND1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCND1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCND1
1 / 2 / 3 3 probe-sets matching KCND1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGCTGGTGG
SOURCE GeneReport for Unigene cluster: Hs.55276
Expression variation in blood from EXPOLDB for KCND1 UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2Tissue specificity: Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain |
Orthologs for KCND1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCND1 gene from 5/8 species (see all 8
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCND11 |
-- |
potassium voltage-gated channel, Shal-related subfamily, more |
90.98(n) 97.68(a) |
612548 XM_850279.1 XP_855372.1 |
chimpanzee (Pan troglodytes) |
KCND11 |
-- |
potassium voltage-gated channel, Shal-related subfamily, more |
99.25(n) 99.83(a) |
465624 XM_521053.2 XP_521053.2 |
cow (Bos taurus) |
KCND11 |
-- |
potassium voltage-gated channel, Shal-related subfamily, more |
91.71(n) 96.29(a) |
518384 NM_001024553.1 NP_001019724.1 |
rat (Rattus norvegicus) |
Kcnd11 |
-- |
potassium voltage-gated channel, Shal-related family, more |
87.64(n) 95.36(a) |
116695 XM_217601.3 XP_217601.2 |
mouse (Mus musculus) |
Kcnd11, 5 |
X (2.20 cM)5
|
potassium voltage-gated channel, Shal-related family, more1, 5 |
87.38(n)1 95.05(a)1 |
165061 NM_008423.11 NP_032449.11 AK0041445 AK0338055 (see all 12) |
About this table Species with no ortholog for KCND1
ENSEMBL Gene Tree for KCND1 | Paralogs for KCND1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCND1 gene
- KCND22 KCND32 KCNA72
|
SNPs/Variants for KCND1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCND1 (up to first 250kb)
|
Disorders & Mutations for KCND1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300281
|
Medical News for KCND1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCND1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for KCND1 gene:- Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)1, 2, 3, 4 Isbrandt D.... Pongs O. (2000)
- Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)1, 3, 4 Jerng H.H.... Pfaffinger P.J. (2004)
- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)2, 3 Gutman G.A....Wang X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. (PubMed id 11423117)3 Nakamura T.Y....Coetzee W.A. (2001)
- Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. (PubMed id 10479680)3 Kurschner C. and Yuzaki M. (1999)
- Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. (PubMed id 14980206)1 Zhou W....Choe S. (2004)
|
Search for KCND1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCND1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCND1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCND1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCND1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCND1:

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| | | | Tocris compounds for KCND1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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