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KCND1 Gene

protein-coding   GIFtS: 60
GCID: GC0XM048818

Potassium Voltage-Gated Channel, Shal-Related Subfamily,...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 11 2
Voltage-Gated Potassium Channel Subunit Kv4.12 3
KV4.12
Potassium Voltage-Gated Channel Subfamily D Member 12
Shal-Type Potassium Channel2

External Ids:    HGNC: 62371   Entrez Gene: 37502   Ensembl: ENSG000001020577   OMIM: 3002815   UniProtKB: Q9NSA23   

Export aliases for KCND1 gene to outside databases

Previous GC identifers: GC0XM047621 GC0XM047079 GC0XM047864 GC0XM048574 GC0XM048703 GC0XM046474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCND1 Gene:
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type
potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated
potassium channels is important in a number of physiological processes, among them the regulation of
neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. (provided by RefSeq, Aug
2013)

GeneCards Summary for KCND1 Gene:
KCND1 (potassium voltage-gated channel, Shal-related subfamily, member 1) is a protein-coding gene. GO annotations related to this gene include delayed rectifier potassium channel activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May
contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by
interactions with other alpha subunits and with regulatory subunits

summary for KCND1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCND1 gene promoter:
         Pax-5   NRSF form 1   SREBP-1c   Nkx2-5   NRSF form 2   SREBP-1b   c-Ets-1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCND1 promoter sequence
   Search Chromatin IP Primers for KCND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

KCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCND1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048818:  view genomic region     (about GC identifiers)

Start:
48,818,639 bp from pter      End:
48,828,251 bp from pter
Size:
9,613 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily D member 1  
Size: 647 amino acids; 71330 Da
Subunit: Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1,
KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable)
Secondary accessions: B2RCG0 O75671

Explore the universe of human proteins at neXtProt for KCND1: NX_Q9NSA2

Explore proteomics data for KCND1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn352, Asn355
  • Modification sites at PhosphoSitePlus

  • See KCND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004970.3  
    ENSEMBL proteins: 
     ENSP00000365660   ENSP00000218176   ENSP00000413989  
    Reactome Protein details: Q9NSA2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv4.1
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 12):
     IPR005821 Ion_trans_dom
     IPR024587 K_chnl_volt-dep_Kv4_C
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027359 Channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q9NSA2

    ProtoNet protein and cluster: Q9NSA2

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003975 Shal voltage-gated K+ channel family signature
    IPB004054 Kv4.1 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily


    Find genes that share domains with KCND1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCND1_HUMAN, Q9NSA2
    Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May
    contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by
    interactions with other alpha subunits and with regulatory subunits

         Genatlas biochemistry entry for KCND1:
    potassium voltage-gated channel,Shal-related family member 1,expressed in fetal heart,infant brain,colon

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with KCND1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCND1:
     Increased Salmonella enterica   Synthetic lethal with gemcitab 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCND1
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    miRNA
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    hsa-mir-26b-5p (MIRT029175), hsa-mir-1 (MIRT023663)

    Block miRNA regulation of human, mouse, rat KCND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCND1 (see all 39):
    hsa-miR-765 hsa-miR-766 hsa-miR-218 hsa-miR-1184 hsa-miR-508-5p hsa-miR-378 hsa-miR-4293 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidKCND1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KCND1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCND1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCND1_HUMAN, Q9NSA2: Membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0030425dendrite IEA--

    Find genes that share ontologies with KCND1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCND1 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Find genes that share SuperPaths with KCND1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCND1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCND1
        Voltage gated Potassium channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCND1
    Interactions:

        Search GeneGlobe Interaction Network for KCND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCND1 (Q9NSA23 ENSP000002181764) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL16Q140053, ENSP000003029354I2D: score=4 STRING: ENSP00000302935
    KCNIP1Q9NZI23, ENSP000003953234I2D: score=1 STRING: ENSP00000395323
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with KCND1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCND1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    2 IUPHAR Ligands for KCND1 (Kv4.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    4-aminopyridine
    Pore BlockerNone210729221
    tetraethylammonium
    Pore BlockerNone212349911



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCND1 gene: 
    NM_004979.5  

    Unigene Cluster for KCND1:

    Potassium voltage-gated channel, Shal-related subfamily, member 1
    Hs.55276  [show with all ESTs]
    Unigene Representative Sequence: BC045659
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376477(uc004dlw.1) ENST00000218176(uc004dlx.1) ENST00000419374

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KCND1 (see all 39):
    hsa-miR-765 hsa-miR-766 hsa-miR-218 hsa-miR-1184 hsa-miR-508-5p hsa-miR-378 hsa-miR-4293 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidKCND1 3' UTR sequence
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    Additional mRNA sequence: 

    AB021865.1 AF166003.1 AJ005898.1 AK315092.1 BC045659.1 

    2 DOTS entries:

    DT.442563  DT.99930272 

    Selected AceView cDNA sequences (see all 26):

    NM_004979 F07466 F03868 AJ005898 AK094431 T35424 F05846 AL120075 
    Z38762 AF166003 AI150825 Z40519 BX280616 AB021865 BC045659 BG181761 
    Z44902 BG194738 AI818239 AI936041 R16330 R41406 W02729 R19492 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCND1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:        -     -           -                                       
    SP2:                          -                                       
    SP3:                          -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for KCND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGGTGG
    KCND1 Expression
    About this image


    KCND1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Hindlimb Ventral Muscle
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
             Hindlimb Ventral Muscle
    KCND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55276

    UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
    Tissue specificity: Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus;
    detected at lower levels in the other parts of the brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCND1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnd11 , 5 potassium voltage-gated channel, Shal-related family, more1, 5 87.33(n)1
    95.05(a)1
      X (3.53 cM)5
    165061  NM_008423.11  NP_032449.11 
     78222895 
    lizard
    (Anolis carolinensis)
    Reptilia KCND16
    potassium voltage-gated channel, Shal-related subf...
    73(a)
    1 ↔ 1
    GL343326.1(1134769-1229754)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004883871 potassium voltage-gated channel subfamily D member more 72.97(n)
    79.37(a)
      100488387  XM_004920250.1  XP_004920307.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnd11 potassium voltage-gated channel, Shal-related subfamily, more 73.21(n)
    80.06(a)
      100001681  NM_001126470.1  NP_001119942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Shal3 potassium ion transport voltage-gated
    potassium more
    71(a)   76B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y73B6BL.193   -- 61(a)   IV(6378470-6384170)   --


    ENSEMBL Gene Tree for KCND1 (if available)
    TreeFam Gene Tree for KCND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCND1 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCNA32  KCND32  KCNA102  
    Selected SIMAP similar genes for KCND1 using alignment to 3 protein entries:     KCND1_HUMAN (see all proteins) (see all similar genes):
    KCND2    KCND3    KCNB2    KCNA1    KCNA10    KCNA2
    KCNA3    KCNA4    KCNG4    KCNB1    KCNS3    KCNV1
    KCNA7    KCNF1    KCNG1    KCNA5    KCNC1    KCNS1

    Find genes that share paralogs with KCND1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCND1 (see all 176)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923681601,2
    --46474601(+) TGTATC/TCCTAG 1 -- ds50010--------
    rs1436260811,2
    --46474710(+) TCTCAC/TCCAGG 1 -- ds50010--------
    rs30274851,2
    C,F,H--48737925(-) ACACAT/CAGTTA 1 -- ds50015Minor allele frequency- C:0.01NS NA 680
    rs10035901,2
    C,F,O,A,H--48738024(-) AGCCAA/GTGAGA 1 -- ds500126Minor allele frequency- G:0.30MN NS EA NA WA CSA 2943
    rs1830203761,2
    --48738036(+) TAGATG/TAACTC 1 -- ds50010--------
    rs30274841,2
    C,H--48738339(-) TCAGGC/TTGAAA 1 -- ut31 ese36Minor allele frequency- T:0.00NS EA NA 422
    rs1879785931,2
    --48738475(+) AGGCCA/GGAGCC 1 -- ut310--------
    rs1918721151,2
    --48738609(+) AGGACA/GCAAAC 1 -- ut310--------
    rs1387064431,2
    C--48738648(+) TAGAGA/GTGGCC 1 -- ut310--------
    rs1402148351,2
    C--48739027(+) CATATC/TCCAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCND1 (48818639 - 48828251 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCND1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513606CNV Insertion21212237
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): KCND1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCND1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300281    OMIM disorders: --


    Find genes that share disorders with KCND1           About GenesLikeMe


    Export disorders for KCND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCND1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KCND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)1, 2, 3, 9 Isbrandt D.... Pongs O. (Genomics 2000)
    2. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)1, 2, 9 Jerng H.H.... Pfaffinger P.J. (Biophys. J. 2004)
    3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Involvement of Kv4.1 K(+) channels in gastric cancer cell proliferation. (PubMed id 20930388)1 Kim H.J....Lee S.Y. (amp 2010)
    7. Silencing of Kv4.1 potassium channels inhibits cell proliferation of tumorigenic human mammary epithelial cells. (PubMed id 19401188)1 Jang S.H....Lee S.Y. (Biochem. Biophys. Res. Commun. 2009)
    8. Volume regulation in the human airway epithelial cell line Calu-3. (PubMed id 19448731)1 Harron S.A....Cowley E.A. (Can. J. Physiol. Pharmacol. 2009)
    9. Electrophysiological properties of human adipose tissue-derived stem cells. (PubMed id 17687001)1 Bai X....Alt E. (Am. J. Physiol., Cell Physiol. 2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3750 HGNC: 6237 AceView: KCND1 Ensembl:ENSG00000102057 euGenes: HUgn3750
    ECgene: KCND1 H-InvDB: KCND1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCND1 gene:
    Search GeneIP for patents involving KCND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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