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KCND1 Gene

protein-coding   GIFtS: 56

GC0XM048703
potassium voltage-gated channel, Shal-related subfamily, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
KV4.1 2
Kv4.1 1
OTTHUMP00000025805 2
Descriptions
Voltage-gated potassium channel subunit Kv4.1 3
potassium voltage-gated channel, Shal-related subfamily,
member 1 2
shal-type potassium channel 2
voltage-gated potassium channel Kv4.1 2
External Ids
HGNC: 62371
Entrez Gene: 37502
UniProtKB: Q9NSA23
Ensembl: ENSG000001020577
Search outside databases for aliases for KCND1 gene

Previous GC identifers: GC0XM047621 GC0XM047079 GC0XM047864 GC0XM048574

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCND1:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion
channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the
potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated
A-type potassium ion channels and are prominent in the repolarization phase of the action
potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in
skeletal muscle. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium
channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel
properties are modulated by interactions with other alpha subunits and with regulatory subunits

Gene Wiki entry for KCND1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCND1 gene  

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

KCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048703:     (about GC identifiers)

Start:
48,703,583 bp from pter
End:
48,713,195 bp from pter
Size:
9,613 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily D member 1  
Size: 647 amino acids; 71330 Da
Subunit: Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory
subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O75671

REFSEQ proteins: NP_004970.3  

ENSEMBL proteins: 
ENSP00000218176 ENSP00000365660 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0008076 voltage-gated potassium channel complex IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for KCND1: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of KCND1
Sigma-Aldrich Antibodies for KCND1
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KCND1

Assays for KCND1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/8 InterPro domains/families (see all 8 ):
 IPR005821 Ion_trans
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR004054 K_chnl_volt-dep_Kv4.1
 IPR003975 K_chnl_volt-dep_Kv4


   GeneDecks  KCND1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9NSA2

ProtoNet protein and cluster: Q9NSA2

4 Blocks protein families:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003975 Shal voltage-gated K+ channel family signature
IPB004054 Kv4.1 voltage-gated K+ channel signature


UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of
positively charged amino acids at every third position
Similarity: Belongs to the potassium channel family. D (Shal) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCND1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCND1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004979

              Applied Biosystems Silencer® siRNAs for KCND1

              Sigma-Aldrich siRNA and siRNA Panels for KCND1  
                     Sigma-Aldrich shRNA Panels and shRNA for KCND1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for KCND1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004979
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004979
                                 untagged cDNA clone in CMV expression vector: NM_004979 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004979

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium
channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel
properties are modulated by interactions with other alpha subunits and with regulatory subunits

Genatlas biochemistry entry for KCND1:
potassium voltage-gated channel,Shal-related family member 1,expressed in fetal heart,infant
brain,colon

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity NAS--
GO:0005515 protein binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for KCND1
  outward current

   GeneDecks  KCND1 for the pathways selected above  
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5/7 Interacting proteins for KCND1 (ENSP000002181763) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
KCNIP4ENSP000003464083STRING (score=.842)
KCNIP2ENSP000003478773STRING (score=.837)
KCNAB2ENSP000003673233STRING (score=.735)
FREQENSP000003614753STRING (score=.726)
VSNL1ENSP000002951563STRING (score=.721)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport NAS--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCND1 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCND1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCND1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004979

              Sigma-Aldrich siRNA and siRNA Panels for KCND1  
                     Sigma-Aldrich shRNA Panels and shRNA for KCND1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004979  

REFSEQ mRNAs for KCND1 gene: 

NM_004979.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004979  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004979
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004979
                                 untagged cDNA clone in CMV expression vector: NM_004979 

Additional cDNA sequence: 

AB021865.1 AF166003.1 AJ005898.1 AK315092.1 BC045659.1 

2 DOTS entries:

DT.442563  DT.99930272 

24/26 AceView cDNA sequences (see all 26 ):

F03868 T35424 AK094431 AL120075 NM_004979 AJ005898 F07466 Z38762 
AF166003 F05846 AI150825 BC045659 BX280616 AB021865 Z40519 BG194738 
Z44902 BG181761 AI818239 AI936041 R16330 R41406 R61454 W02729 

highest scoring ESTs for KCND1:

AJ005898 AB021865 AF166003 AL120075 BC045659 AI150825 AI694424 AK094431 BG181761 BG194738 

Unigene Cluster for KCND1:

Potassium voltage-gated channel, Shal-related subfamily, member 1
Hs.55276  [show with all ESTs]
Unigene Representative Sequence: BC045659


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KCND1

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:        -     -           -                                       
SP2:                          -                                       
SP3:                          -                                       
SP4:                                                                  

About this scheme

ECgene alternative splicing isoforms for KCND1

2 Ensembl transcripts including schematic representations:
ENST00000218176  ENST00000376477  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCND1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCND1

1 / 2 / 3

3 probe-sets matching KCND1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

40021_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AJ005898 1.00 1.00 1.00 1

206842_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004979 0.60 1.00 0.82 1

206842_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAGCTGGTGG

SOURCE GeneReport for Unigene cluster: Hs.55276

Expression variation in blood from EXPOLDB for KCND1

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Tissue specificity: Widely expressed. Highly expressed in brain, in particular in cerebellum and
thalamus; detected at lower levels in the other parts of the brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCND1 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCND11   -- potassium voltage-gated channel, Shal-related subfamily, more 90.98(n)
97.68(a)
612548  XM_850279.1  XP_855372.1 
chimpanzee
(Pan troglodytes)
KCND11   -- potassium voltage-gated channel, Shal-related subfamily, more 99.25(n)
99.83(a)
465624  XM_521053.2  XP_521053.2 
cow
(Bos taurus)
KCND11   -- potassium voltage-gated channel, Shal-related subfamily, more 91.71(n)
96.29(a)
518384  NM_001024553.1  NP_001019724.1 
rat
(Rattus norvegicus)
Kcnd11   -- potassium voltage-gated channel, Shal-related family, more 87.64(n)
95.36(a)
116695  XM_217601.3  XP_217601.2 
mouse
(Mus musculus)
Kcnd11, 5 X (2.20 cM)5
potassium voltage-gated channel, Shal-related family, more1, 5 87.38(n)1
95.05(a)1
165061  NM_008423.11  NP_032449.11 
 AK0041445  AK0338055  (see all 12)
About this table        Species with no ortholog for KCND1

ENSEMBL Gene Tree for KCND1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCND1 gene
KCND22  KCND32  KCNA72  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/24 NCBI SNPs in KCND1 are shown (see all 24 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 27)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs22389771,2
A,C,F,H,O48711920(-) ACCCTC/GCCTCA 1 -- ut514Minor allele frequency- G:0.36EU EA WA 414
rs10035901,2
A,C,F,H,O48703380(-) AGCCAA/GTGAGA 1 -- ng5112Minor allele frequency- G:0.27EU EA WA NA 1093
rs30274811,2
A,C,F,O48713511(-) TTAACT/AGACGC 1 -- ng312Minor allele frequency- A:0.12EA 180
rs37615501,2
C,F,H48714030(-) gataaG/Atctct 1 -- ng314Minor allele frequency- A:0.10EU EA WA 418
rs30274821,2
C,H48708000(-) AGGCTC/GTTTGT 1 L/V mis14Minor allele frequency- G:0.00EU EA WA 418
rs30274841,2
H48703695(-) TCAGGC/TTGAAA 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 418
rs20640341,2
A,C,F,H,O48708920(+) CAAAAC/TAGGGA 1 -- int1 ese38Minor allele frequency- N:0.00EU EA WA NA 632
rs120072201,2
A,C,H48705931(+) gatacG/Aaagtg 1 -- int14Minor allele frequency- A:0.00EU EA WA 418
--
rs66098201,2
A48707121(+) acttgG/Tgaggc 1 -- int10--------
rs356446011,2
--48708321(-) ACCAGC/TGGGCT 1 R/W mis11Minor allele frequency- T:0.02NA 62
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HapMap Linkage Disequilibrium images for KCND1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300281

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for KCND1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3750 HGNC: 6237 AceView: KCND1 Ensembl:ENSG00000102057 euGenes: HUgn3750
ECgene: KCND1 H-InvDB: KCND1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCND1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Predesigned and custom siRNAs for KCND1 Antibodies for KCND1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCND1 Browse small molecules at Sigma-Aldrich
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