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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCND1 Gene

protein-coding   GIFtS: 60
GCID: GC0XM048818

potassium voltage-gated channel, Shal-related subfamily,...
 Explore 2 diseases affiliated with
KCND1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCND1    

Aliases
for KCND1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 11 2     Potassium Voltage-Gated Channel Subfamily D Member 12
Voltage-Gated Potassium Channel Subunit Kv4.12 3     Shal-Type Potassium Channel2
Kv4.11     Voltage-Gated Potassium Channel Kv4.12
KV4.12     

External Ids:    HGNC: 62371   Entrez Gene: 37502   Ensembl: ENSG000001020577   OMIM: 3002815   UniProtKB: Q9NSA23   

Export aliases for KCND1 gene to outside databases

Previous GC identifers: GC0XM047621 GC0XM047079 GC0XM047864 GC0XM048574 GC0XM048703 GC0XM046474


Summaries
for KCND1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCND1:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,
voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are
prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all
tissues analyzed, with lower levels in skeletal muscle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute
to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other
alpha subunits and with regulatory subunits

summary for KCND1:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCND1


Genomic Views
for KCND1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCND1 gene promoter:
         Pax-5   NRSF form 1   SREBP-1c   Nkx2-5   NRSF form 2   SREBP-1b   c-Ets-1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCND1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

KCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCND1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048818:  view genomic region     (about GC identifiers)

Start:
 48,818,639 bp from pter      End:
 48,828,251 bp from pter
Size:
 9,613 bases      Orientation:
 minus strand

Proteins
for KCND1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily D member 1  
Size: 647 amino acids; 71330 Da
Subunit: Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1,
KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable)
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity)
Secondary accessions: B2RCG0 O75671

Explore the universe of human proteins at neXtProt for KCND1: NX_Q9NSA2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NSA2

    • KCND1 Protein expression data from MOPED and PaxDb:    About this image 
    KCND1 Protein Expression
    REFSEQ proteins: NP_004970.3  
    ENSEMBL proteins: 
     ENSP00000365660   ENSP00000218176   ENSP00000413989  
    Reactome Protein details: Q9NSA2
    Human Recombinant Protein Products for KCND1: 
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    Uscn Proteins for KCND1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0030425dendrite IEA--

    KCND1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCND1

    Protein Domains /
    Families
    for KCND1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCND1 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR005821 Ion_trans_dom
     IPR024587 K_chnl_volt-dep_Kv4_C
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR004054 K_chnl_volt-dep_Kv4.1

    Graphical View of Domain Structure for InterPro Entry Q9NSA2

    ProtoNet protein and cluster: Q9NSA2

    4 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003975 Shal voltage-gated K+ channel family signature
    IPB004054 Kv4.1 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily


    Function
    for KCND1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCND1_HUMAN, Q9NSA2
    Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute
    to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other
    alpha subunits and with regulatory subunits

         Genatlas biochemistry entry for KCND1:
    potassium voltage-gated channel,Shal-related family member 1,expressed in fetal heart,infant brain,colon

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005249voltage-gated potassium channel activity NAS--
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0046872metal ion binding IEA--
         
    KCND1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCND1:
     Increased Salmonella enterica   Synthetic lethal with gemcitab 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCND1 

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate KCND1 (see all 39):
    hsa-miR-765 hsa-miR-766 hsa-miR-218 hsa-miR-1184 hsa-miR-508-5p hsa-miR-378 hsa-miR-4293 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: KCND1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for KCND1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCND1
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCND1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCND1
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCND1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for KCND1 (Q9NSA23 ENSP000002181764) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL16Q140053, ENSP000003029354I2D: score=4 STRING: ENSP00000302935
    KCNIP1Q9NZI23, ENSP000003953234I2D: score=1 STRING: ENSP00000395323
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport NAS--
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--

    KCND1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCND1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCND1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    Search CenterWatch for drugs/clinical trials and news about KCND1 

    Transcripts
    for KCND1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCND1 gene: 
    NM_004979.4  

    Unigene Cluster for KCND1:

    Potassium voltage-gated channel, Shal-related subfamily, member 1
    Hs.55276  [show with all ESTs]
    Unigene Representative Sequence: BC045659
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376477(uc004dlw.1) ENST00000218176(uc004dlx.1) ENST00000419374


    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate KCND1 (see all 39):
    hsa-miR-765 hsa-miR-766 hsa-miR-218 hsa-miR-1184 hsa-miR-508-5p hsa-miR-378 hsa-miR-4293 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: KCND1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KCND1
    OriGene siRNA: KCND1
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    Clone
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    Additional cDNA sequence: 

    AB021865.1 AF166003.1 AJ005898.1 AK315092.1 BC045659.1 

    2 DOTS entries:

    DT.442563  DT.99930272 

    24/26 AceView cDNA sequences (see all 26):

    AK094431 NM_004979 AL120075 Z38762 F07466 AJ005898 F03868 T35424 
    AF166003 F05846 Z40519 BC045659 BX280616 AB021865 AI150825 BG181761 
    Z44902 BG194738 AI936041 AI818239 R16330 R41406 W02729 R61454 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCND1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:        -     -           -                                       
    SP2:                          -                                       
    SP3:                          -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for KCND1

    Expression
    for KCND1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCTGGTGG
    KCND1 Expression
    About this image

    KCND1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbHindlimb Ventral MuscleLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCND1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCND1

    SOURCE GeneReport for Unigene cluster: Hs.55276

    UniProtKB/Swiss-Prot: KCND1_HUMAN, Q9NSA2
    Tissue specificity: Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at
    lower levels in the other parts of the brain

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    In Situ
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    Orthologs
    for KCND1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCND1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia KCND16
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343326.1(1134769-1229754)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000016811 potassium voltage-gated channel, Shal-related subfamily, more 73.31(n)
    80.06(a)    		   100001681  NM_001126470.1  NP_001119942.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shal3 potassium ion transport voltage-gated
    potassium more    		 71(a)   76B7   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y73B6BL.193   -- 61(a)   IV(6378470-6384170)   --


    ENSEMBL Gene Tree for KCND1 (if available)
    TreeFam Gene Tree for KCND1 (if available) 

    Paralogs
    for KCND1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCND1 gene
    KCNA62  KCNA22  KCNC22  KCNC42  KCND22  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCND32  KCNA32  KCNA102  
    18/20 SIMAP similar genes for KCND1 using alignment to 3 protein entries:     KCND1_HUMAN (see all proteins) (see all similar genes):
    KCND2    KCND3    KCNB2    KCNA1    KCNA10    KCNA2
    KCNA3    KCNA4    KCNG4    KCNB1    KCNS3    KCNV1
    KCNA7    KCNF1    KCNG1    KCNA5    KCNC1    KCNS1

    KCND1 for paralogs           About GeneDecksing



    Genomic Variants
    for KCND1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 NCBI SNPs in KCND1 are shown (see all 122)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs30274851,2
    		C,F,H--48818337(-) ACACAT/CAGTTA 1 -- ds50015Minor allele frequency- C:0.01NS NA 680
    rs10035901,2
    		C,F,O,A,H--48818436(-) AGCCAA/GTGAGA 1 -- ds500126Minor allele frequency- G:0.30MN NS EA NA WA CSA 2943
    rs1830203761,2
    		--48818448(+) TAGATG/TAACTC 1 -- ds50010--------
    rs30274841,2
    		C,H--48818751(-) TCAGGC/TTGAAA 1 -- ut31 ese36Minor allele frequency- T:0.00NS EA NA 422
    rs1879785931,2
    		--48818887(+) AGGCCA/GGAGCC 1 -- ut310--------
    rs1918721151,2
    		--48819021(+) AGGACA/GCAAAC 1 -- ut310--------
    rs1387064431,2
    		--48819060(+) TAGAGA/GTGGCC 1 -- ut310--------
    rs1402148351,2
    		--48819439(+) CATATC/TCCAGC 1 -- ut310--------
    rs1504454111,2
    		--48819483(+) AGGCTA/GGAGCT 1 -- ut310--------
    rs1844742641,2
    		--48819756(+) CAAGCC/GTGCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCND1 (48818639 - 48828251 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KCND1
         1 CNV: 7789
    Locus Specific Mutation Databases (LSDB): KCND1

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    Disorders / Diseases
    for KCND1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCND1 for disorders           About GeneDecksing

    OMIM gene information: 300281    OMIM disorders: --

    2 diseases for KCND1:    About MalaCards
    neuronitis    hermaphroditism


    Export disorders for KCND1 gene to outside databases

    Publications
    for KCND1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCND1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCND1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PubMed id 10729221)1, 2, 3, 9 Isbrandt D.... Pongs O. (2000)
    2. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)1, 2, 9 Jerng H.H.... Pfaffinger P.J. (2004)
    3. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Silencing of Kv4.1 potassium channels inhibits cell p roliferation of tumorigenic human mammary epithelial cells. (PubMed id 19401188)1 Jang S.H....Lee S.Y. (2009)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. (PubMed id 11423117)1 Nakamura T.Y....Coetzee W.A. (2001)
    9. Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. (PubMed id 10479680)1 Kurschner C. and Yuzaki M. (1999)
    10. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. (PubMed id 14980206)9 Zhou W....Choe S. (2004)

    External Searches for KCND1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing KCND1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3750 HGNC: 6237 AceView: KCND1 Ensembl:ENSG00000102057 euGenes: HUgn3750
    ECgene: KCND1 H-InvDB: KCND1

    Other Databases showing KCND1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCND1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCND1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCND1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCND1 gene:
    Search GeneIP for patents involving KCND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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