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Aliases for KCND1 Gene

Aliases for KCND1 Gene

  • Potassium Channel, Voltage Gated Shal Related Subfamily D, Member 1 2 3
  • Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 1 2 3
  • Voltage-Gated Potassium Channel Subunit Kv4.1 3 4
  • Potassium Voltage-Gated Channel Subfamily D Member 1 3
  • Shal-Type Potassium Channel 3
  • KV4.1 3

External Ids for KCND1 Gene

Summaries for KCND1 Gene

Entrez Gene Summary for KCND1 Gene

  • This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

GeneCards Summary for KCND1 Gene

KCND1 (Potassium Channel, Voltage Gated Shal Related Subfamily D, Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include voltage-gated potassium channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCND1 Gene

  • Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

Tocris Summary for KCND1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCND1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCND1 Gene

Genomics for KCND1 Gene

Genomic Location for KCND1 Gene

Start:
48,961,378 bp from pter
End:
48,971,844 bp from pter
Size:
10,467 bases
Orientation:
Minus strand

Genomic View for KCND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCND1 Gene

Proteins for KCND1 Gene

  • Protein details for KCND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA2-KCND1_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily D member 1
    Protein Accession:
    Q9NSA2
    Secondary Accessions:
    • A6NEF1
    • B2RCG0
    • O75671

    Protein attributes for KCND1 Gene

    Size:
    647 amino acids
    Molecular mass:
    71330 Da
    Quaternary structure:
    • Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable).

    Alternative splice isoforms for KCND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCND1 Gene

Proteomics data for KCND1 Gene at MOPED

Post-translational modifications for KCND1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn352 and Asn355

Other Protein References for KCND1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCND1 Gene

Domains for KCND1 Gene

Gene Families for KCND1 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCND1_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q9NSA2
Family:
  • Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.:
    • Q9NSA2
genes like me logo Genes that share domains with KCND1: view

Function for KCND1 Gene

Molecular function for KCND1 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Shal-related family member 1,expressed in fetal heart,infant brain,colon
UniProtKB/Swiss-Prot Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

Gene Ontology (GO) - Molecular Function for KCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KCND1: view

Phenotypes for KCND1 Gene

genes like me logo Genes that share phenotypes with KCND1: view

miRNA for KCND1 Gene

miRTarBase miRNAs that target KCND1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCND1 Gene

Localization for KCND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCND1 Gene

Membrane; Multi-pass membrane protein. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCND1 Gene COMPARTMENTS Subcellular localization image for KCND1 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCND1: view

Pathways for KCND1 Gene

genes like me logo Genes that share pathways with KCND1: view

Pathways by source for KCND1 Gene

1 Qiagen pathway for KCND1 Gene

Gene Ontology (GO) - Biological Process for KCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCND1: view

Compounds for KCND1 Gene

(5) Tocris Compounds for KCND1 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(2) IUPHAR Ligand for KCND1 Gene

Ligand Type Action Affinity Pubmed IDs
4-aminopyridine Inhibitor None
tetraethylammonium Inhibitor None
genes like me logo Genes that share compounds with KCND1: view

Transcripts for KCND1 Gene

mRNA/cDNA for KCND1 Gene

Unigene Clusters for KCND1 Gene

Potassium voltage-gated channel, Shal-related subfamily, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCND1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for KCND1 Gene

GeneLoc Exon Structure for
KCND1
ECgene alternative splicing isoforms for
KCND1

Expression for KCND1 Gene

mRNA expression in normal human tissues for KCND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCND1 Gene

This gene is overexpressed in Brain - Cerebellum (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCND1 Gene

SOURCE GeneReport for Unigene cluster for KCND1 Gene Hs.55276

mRNA Expression by UniProt/SwissProt for KCND1 Gene

Q9NSA2-KCND1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.
genes like me logo Genes that share expressions with KCND1: view

Orthologs for KCND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCND1 36
  • 99.25 (n)
  • 99.83 (a)
KCND1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCND1 36
  • 91.04 (n)
  • 95.52 (a)
KCND1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCND1 36
  • 90.93 (n)
  • 97.68 (a)
KCND1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnd1 36
  • 87.33 (n)
  • 95.05 (a)
Kcnd1 16
Kcnd1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCND1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCND1 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnd1 36
  • 87.58 (n)
  • 95.36 (a)
lizard
(Anolis carolinensis)
Reptilia KCND1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488387 36
  • 72.97 (n)
  • 79.37 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnd1 36
  • 73.21 (n)
  • 80.06 (a)
kcnd1 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Shal 37
  • 64 (a)
OneToMany
Shal 38
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea shl-1 37
  • 58 (a)
OneToMany
Y73B6BL.19 38
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9633 37
  • 45 (a)
OneToMany
Species with no ortholog for KCND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCND1 Gene

ENSEMBL:
Gene Tree for KCND1 (if available)
TreeFam:
Gene Tree for KCND1 (if available)

Paralogs for KCND1 Gene

Selected SIMAP similar genes for KCND1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCND1: view

Variants for KCND1 Gene

Sequence variations from dbSNP and Humsavar for KCND1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1003590 -- 48,961,175(-) AGCCA(A/G)TGAGA downstream-variant-500B
rs2064034 -- 48,967,569(+) CAAAA(C/T)AGGGA intron-variant
rs2238977 -- 48,970,569(-) ACCCT(C/G)CCTCA utr-variant-5-prime
rs3027481 -- 48,972,160(-) TTAAC(A/T)GACGC upstream-variant-2KB
rs3027482 -- 48,966,649(-) AGGCT(C/G)TTTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KCND1 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv513606 CNV Insertion 21212237

Relevant External Links for KCND1 Gene

HapMap Linkage Disequilibrium report
KCND1
Locus Specific Mutation Databases (LSDB)
KCND1

Disorders for KCND1 Gene

No disorders were found for KCND1 Gene.

No data available for UniProtKB/Swiss-Prot for KCND1 Gene

Publications for KCND1 Gene

  1. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). (PMID: 10729221) Isbrandt D. … Pongs O. (Genomics 2000) 2 3 4 23
  2. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PMID: 15454437) Jerng H.H. … Pfaffinger P.J. (Biophys. J. 2004) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3

Products for KCND1 Gene

Sources for KCND1 Gene

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