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KCNC4 Gene

protein-coding GIFtS: 60

GC01P110555

potassium voltage-gated channel, Shaw-related subfamily, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HKSHIIIC ^¹, ²
KSHIIIC ^², ³
KV3.4 ^²
Kv3.4 ^¹
MGC126818 ^²

Descriptions
Shaw-related voltage-gated potassium channel protein 4 ^²
Voltage-gated potassium channel subunit Kv3.4 ^², ³
potassium voltage-gated channel subfamily C member 4 ^²
potassium voltage-gated channel, Shaw-related subfamily, member 4 ^²

External Ids
HGNC: 6236¹
Entrez Gene: 3749²
UniProtKB: Q03721³
Ensembl: ENSG00000116396⁷

Search outside databases for aliases for KCNC4 gene

Previous GC identifers: GC01P111170 GC01P109620 GC01P109856 GC01P110052 GC01P110466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNC4:

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is

comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw

subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel

proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion

permeability of excitable membranes. It generates atypical voltage-dependent transient current

that may be important for neuronal excitability. Several transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNC4_HUMAN, Q03721

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable

membranes. Assuming opened or closed conformations in response to the voltage difference across

the membrane, the protein forms a potassium-selective channel through which potassium ions may

pass in accordance with their electrochemical gradient

Gene Wiki entry for KCNC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNC4 gene

Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p21

KCNC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P110555: (about GC identifiers)

Start:	110,555,588 bp from pter
End:	110,578,189 bp from pter
Size:	22,602 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNC4_HUMAN, Q03721 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily C member 4

Size: 635 amino acids; 69767 Da

Subunit: Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q3MIM4 Q5TBI6

Alternative splicing: 2 isoforms: Q03721-1 Q03721-2

Post-translational modifications:

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001034663.1 NP_004969.2 NP_720198.1

ENSEMBL proteins:

ENSP00000358802

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNC4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	1920536
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNC4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNC4
	Sigma-Aldrich Antibodies for KCNC4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNC4), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCNC4

Assays for KCNC4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q03721

ProtoNet protein and cluster: Q03721

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003974 Shaw voltage-gated K+ channel family signature

IPB005405 Kv3.4 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNC4_HUMAN, Q03721

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Domain: The tail may be important in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Similarity: Belongs to the potassium channel family. C (Shaw) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004978

Applied Biosystems Silencer® siRNAs for KCNC4

Sigma-Aldrich siRNA and siRNA Panels for KCNC4

Sigma-Aldrich shRNA Panels and shRNA for KCNC4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039574
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039574
untagged cDNA clones in CMV expression vector (see all 3): NM_001039574

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004978

UniProtKB/Swiss-Prot: KCNC4_HUMAN, Q03721

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable

membranes. Assuming opened or closed conformations in response to the voltage difference across

the membrane, the protein forms a potassium-selective channel through which potassium ions may

pass in accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNC4:

potassium voltage-gated channel,Drosophila Shaw-related subfamily,member 4 (mouse Kv3.4 homolog)

1 MGI phenotypic allele

for Kcnc4 (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	TAS	1920536
GO:0005515	protein binding	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNC4

5/44 Interacting proteins for KCNC4 (ENSP00000358802³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNH2	ENSP00000262186³	STRING (score=.98)
HCN2	ENSP00000251287³	STRING (score=.959)
KCNJ1	ENSP00000316136³	STRING (score=.956)
KCNJ4	ENSP00000306497³	STRING (score=.954)
KCNE1	ENSP00000337255³	STRING (score=.95)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	1920536
GO:0007268	synaptic transmission	TAS	1381835

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNC4 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

1 Novoseek chemical compound relationship for KCNC4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	32.84	2	1740329 (1), 16449802 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004978

Sigma-Aldrich siRNA and siRNA Panels for KCNC4

Sigma-Aldrich shRNA Panels and shRNA for KCNC4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039574 NM_004978 NM_153763

REFSEQ mRNAs for KCNC4 gene (3 alternative transcripts):

NM_001039574.1 NM_004978.3 NM_153763.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039574 NM_004978 NM_153763

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039574
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039574
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001039574

Additional cDNA sequence:

AK125567.1 AK295076.1 AK310193.1 BC025377.1 BC101769.1 M64676.1

7 DOTS entries:

DT.311563 DT.409905 DT.307427 DT.100641280 DT.99997196 DT.40230555 DT.121387696

24/96 AceView cDNA sequences (see all 96 ):

BM966921 BQ022636 BM765446 Z38845 BM966789 BQ189347 BM966873 CK823243

BX489205 AI860726 AK125567 BX098184 NM_153763 BM966756 AW237067 F03407

BC025377 NM_004978 AA298743 AA326357 BX537638 AW614375 BF589547 BM893669

highest scoring ESTs for KCNC4:

H11376 AA435735 AA678581 AA775645 AA809591 AI240989 AI369490 AI826475 AI916965 AK125567

Unigene Cluster for KCNC4:

Potassium voltage-gated channel, Shaw-related subfamily, member 4

Hs.153521 [show with all ESTs]

Unigene Representative Sequence: NM_004978

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNC4

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c
SP1:									-		-		-
SP2:									-		-		-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for KCNC4

1 Ensembl transcript including schematic representation:

ENST00000369787

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNC4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNC4

¹ / ² / ³

10 probe-sets matching KCNC4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50669_s_at²^{, 3}	U95-B	1	1.00	1.00	0.62	0.82	AI826475	0.80	1.00	0.91	1
49987_at²^{, 3}	U95-B	1	1.00	1.00	0.53	1.57	H11376	1.00	1.00	1.00	1
39189_at²^{, 3}	U95-A	1	1.00	1.00	0.55	0.63	M64676	0.80	1.00	0.91	1
50670_at²^{, 3}	U95-B	1	0.94	1.00	0.30	0.29	AA435735	0.80	1.00	0.91	1
208251_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004978	0.60	1.00	0.82	1
235467_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF969982	0.80	1.00	0.91	1
228436_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF061003	0.80	1.00	0.91	1
208251_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235467_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228436_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTGCTCGA

SOURCE GeneReport for Unigene cluster: Hs.153521
Expression variation in blood from EXPOLDB for KCNC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNC4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNC4¹	--	potassium voltage-gated channel, Shaw-related subfamily, more	91.61(n) 93.71(a)	490114 XM_547235.2 XP_547235.2
chimpanzee (Pan troglodytes)	KCNC4¹	--	potassium voltage-gated channel, Shaw-related subfamily, more	98.64(n) 98.86(a)	457122 XM_001163574.1 XP_001163574.1
cow (Bos taurus)	KCNC4¹	--	potassium voltage-gated channel, Shaw-related subfamily, more	91.09(n) 94.81(a)	540768 XM_613047.3 XP_613047.2
mouse (Mus musculus)	Kcnc4^{1, 5}	3 (53.00 cM)⁵	potassium voltage gated channel, Shaw-related subfamily, more^{1, 5}	89.13(n)¹ 97.03(a)¹	99738¹ NM_145922.2¹ NP_666034.1¹ AI849951⁵ AI850292⁵ (see all 13)
zebrafish (Danio rerio)	DKEY-71L10.1¹	--	novel protein similar to vertebrate potassium voltage-gated more	71.17(n) 73.62(a)	799410 XM_001923984.1 XP_001924019.1

About this table Species with no ortholog for KCNC4

ENSEMBL Gene Tree for KCNC4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNC4 gene

KCNC2² KCNC1² KCNC3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/125 NCBI SNPs in KCNC4 are shown (see all 125 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs12062357^1,2	A,C,F,H	110577448(+)	`TTCCCG/ATCCCC`	2	--	ut3¹ ese³		4		EU EA WA	412
	rs12411176^1,2	A,C,F,H	110567989(+)	`CACCTA/GCAGTG`	3	C/Y	mis¹		5		EU EA WA NA	498
	rs11578913^1,2	C,F,H	110578628(+)	`CTGGTG/AGCACA`	2	--	ng3¹		7		EU EA WA NA	556
--	rs17025562^1,2	C,F,H	110576718(+)	`GGTTCT/CTGGAG`	2	--	ut3¹ int¹ ese³		7		NA EU EA WA	558
	rs7545960^1,2	A,C	110555288(+)	`TCCTCC/GTCTTT`	3	--	ng5¹		0	--	--	--	--
	rs35167146^1,2	C,F	110567382(+)	`TCATCG/TACTTT`	3	D/Y	mis¹		5		NA EU EA WA	484
	rs11810910^1,2	A,C	110555331(+)	`CCAGAA/GCGTTT`	3	--	ng5¹		0	--	--	--	--
	rs11102065^1,2	A,C	110578566(+)	`CAAGAC/TCCTGG`	2	--	ng3¹		0	--	--	--	--
	rs479759^1,2	H	110577378(-)	`TAGCAC/TGTGCA`	2	--	ut3¹ ese³		5		MN EU EA WA	590
	rs2761438^1,2	A	110553662(+)	`CAGGAA/GGGGGT`	3	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KCNC4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176265

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/14 PubMed articles for KCNC4 gene (see all 14 ):

Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. (PubMed id 1740329)^{1, 2, 3} Ghanshani S....Chandy K.G. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action. (PubMed id 9649584)^{3, 4} Beck E.J.... Covarrubias M. (1998)
Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. (PubMed id 7993631)^{3, 4} Covarrubias M.... Vyas T.B. (1994)
Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage- activating, TEA-sensitive, type-A K+ channel. (PubMed id 1381835)^{3, 4} de Miera E.V.-S.... Rudy B. (1992)
Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21. (PubMed id 1920536)^{2, 3} Rudy B....Ward D.C. (1991)
Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. (PubMed id 16449802)^{1, 3} Abbott G.W....Goldstein S.A. (2006)
Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. (PubMed id 15485486)³ Angulo E....Franco R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3749	HGNC: 6236	AceView: KCNC4	Ensembl:ENSG00000116396	euGenes: HUgn3749
ECgene: KCNC4	H-InvDB: KCNC4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNC4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNC4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNC4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNC4		Antibodies for KCNC4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNC4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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KCNC4 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for KCNC4

Summaries
for KCNC4

Genomic Location
for KCNC4

Proteins
for KCNC4

Protein Domains/
Families
for KCNC4

Gene Function
for KCNC4

Pathways & Interactions
for KCNC4

Drugs & Compounds
for KCNC4

Transcripts
for KCNC4

Expression
for KCNC4

Orthologs
for KCNC4

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for KCNC4

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for KCNC4

Disorders & Mutations
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Search for KCNC4

Genome Databases showing KCNC4

Other Databases showing KCNC4

Specialized Databases showing KCNC4

Licensable Technologies
for KCNC4

Services
for KCNC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNC4 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor KCNC4

Summariesfor KCNC4

Genomic Locationfor KCNC4

Proteinsfor KCNC4

Protein Domains/Familiesfor KCNC4

Gene Functionfor KCNC4

Pathways & Interactionsfor KCNC4

Drugs & Compoundsfor KCNC4

Transcriptsfor KCNC4

Expression for KCNC4

Orthologsfor KCNC4

Paralogsfor KCNC4

SNPs/Variantsfor KCNC4

Disorders & Mutationsfor KCNC4

Medical Newsfor KCNC4

Publicationsfor KCNC4

Search for KCNC4

Genome Databases showing KCNC4

Other Databases showing KCNC4

Specialized Databases showing KCNC4

Licensable Technologiesfor KCNC4

Servicesfor KCNC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNC4

Summaries
for KCNC4

Genomic Location
for KCNC4

Proteins
for KCNC4

Protein Domains/
Families
for KCNC4

Gene Function
for KCNC4

Pathways & Interactions
for KCNC4

Drugs & Compounds
for KCNC4

Transcripts
for KCNC4

Expression
for KCNC4

Orthologs
for KCNC4

Paralogs
for KCNC4

SNPs/Variants
for KCNC4

Disorders & Mutations
for KCNC4

Medical News
for KCNC4

Publications
for KCNC4

Licensable Technologies
for KCNC4

Services
for KCNC4