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Aliases for KCNC4 Gene

Aliases for KCNC4 Gene

  • Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 4 2 3
  • Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 2 3
  • KSHIIIC 3 4
  • Potassium Voltage-Gated Channel Subfamily C Member 4 3
  • Voltage-Gated Potassium Channel Subunit KV3.4 3
  • Voltage-Gated Potassium Channel Subunit Kv3.4 4
  • Chromosome 1 Open Reading Frame 30 2
  • K+ Channel Subunit 3
  • HKSHIIIC 3
  • C1orf30 3
  • KV3.4 3

External Ids for KCNC4 Gene

Previous HGNC Symbols for KCNC4 Gene

  • C1orf30

Previous GeneCards Identifiers for KCNC4 Gene

  • GC01P111170
  • GC01P109620
  • GC01P109856
  • GC01P110052
  • GC01P110466
  • GC01P110555
  • GC01P110753
  • GC01P108626

Summaries for KCNC4 Gene

Entrez Gene Summary for KCNC4 Gene

  • The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for KCNC4 Gene

KCNC4 (Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 4) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNC4 Gene

  • This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Tocris Summary for KCNC4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNC4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNC4 Gene

Genomics for KCNC4 Gene

Regulatory Elements for KCNC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNC4 Gene

Start:
110,210,714 bp from pter
End:
110,283,100 bp from pter
Size:
72,387 bases
Orientation:
Plus strand

Genomic View for KCNC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNC4 Gene

Proteins for KCNC4 Gene

  • Protein details for KCNC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03721-KCNC4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily C member 4
    Protein Accession:
    Q03721
    Secondary Accessions:
    • Q3MIM4
    • Q5TBI6

    Protein attributes for KCNC4 Gene

    Size:
    635 amino acids
    Molecular mass:
    69767 Da
    Quaternary structure:
    • Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).

    Three dimensional structures from OCA and Proteopedia for KCNC4 Gene

    Alternative splice isoforms for KCNC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNC4 Gene

Proteomics data for KCNC4 Gene at MOPED

Post-translational modifications for KCNC4 Gene

  • Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.
  • Glycosylation at Asn256 and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNC4 Gene

Domains for KCNC4 Gene

Gene Families for KCNC4 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03721

UniProtKB/Swiss-Prot:

KCNC4_HUMAN :
  • Q03721
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
Family:
  • Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily.
genes like me logo Genes that share domains with KCNC4: view

Function for KCNC4 Gene

Molecular function for KCNC4 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila Shaw-related subfamily,member 4 (mouse Kv3.4 homolog)
UniProtKB/Swiss-Prot Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Gene Ontology (GO) - Molecular Function for KCNC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity TAS 1920536
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity TAS 1740329
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNC4: view
genes like me logo Genes that share phenotypes with KCNC4: view

Animal Model Products

CRISPR Products

miRNA for KCNC4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNC4 Gene

Localization for KCNC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNC4 Gene COMPARTMENTS Subcellular localization image for KCNC4 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for KCNC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0031594 neuromuscular junction IEA --
genes like me logo Genes that share ontologies with KCNC4: view

Pathways for KCNC4 Gene

genes like me logo Genes that share pathways with KCNC4: view

Pathways by source for KCNC4 Gene

1 Qiagen pathway for KCNC4 Gene

Interacting Proteins for KCNC4 Gene

Gene Ontology (GO) - Biological Process for KCNC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 1920536
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with KCNC4: view

Compounds for KCNC4 Gene

(5) Tocris Compounds for KCNC4 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(1) HMDB Compounds for KCNC4 Gene

Compound Synonyms Cas Number PubMed IDs
Potassium
  • K+
7440-09-7

(1) Drugbank Compounds for KCNC4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphonoserine
target

(2) IUPHAR Ligand for KCNC4 Gene

Ligand Type Action Affinity Pubmed IDs
tetraethylammonium Inhibitor None
sea anemone toxin BDS-I Inhibitor None

(1) Novoseek inferred chemical compound relationships for KCNC4 Gene

Compound -log(P) Hits PubMed IDs
potassium 29.4 2
genes like me logo Genes that share compounds with KCNC4: view

Transcripts for KCNC4 Gene

Unigene Clusters for KCNC4 Gene

Potassium voltage-gated channel, Shaw-related subfamily, member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCNC4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for KCNC4 Gene

GeneLoc Exon Structure for
KCNC4
ECgene alternative splicing isoforms for
KCNC4

Expression for KCNC4 Gene

mRNA expression in normal human tissues for KCNC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNC4 Gene

SOURCE GeneReport for Unigene cluster for KCNC4 Gene Hs.153521

genes like me logo Genes that share expressions with KCNC4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNC4 Gene

Orthologs for KCNC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNC4 35
  • 99.36 (n)
  • 99.68 (a)
KCNC4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNC4 35
  • 92.46 (n)
  • 96.15 (a)
KCNC4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNC4 35
  • 91.08 (n)
  • 92.63 (a)
KCNC4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnc4 35
  • 89.13 (n)
  • 97.03 (a)
Kcnc4 16
Kcnc4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNC4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNC4 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnc4 35
  • 89.46 (n)
  • 97.2 (a)
chicken
(Gallus gallus)
Aves KCNC4 35
  • 78.29 (n)
  • 82.81 (a)
KCNC4 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNC4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnc4 35
  • 70.54 (n)
  • 79.86 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnc4 35
  • 71.06 (n)
  • 73.62 (a)
kcnc4 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Shaw 37
  • 48 (a)
CG4450 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea shw-3 37
  • 42 (a)
Species with no ortholog for KCNC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNC4 Gene

ENSEMBL:
Gene Tree for KCNC4 (if available)
TreeFam:
Gene Tree for KCNC4 (if available)

Paralogs for KCNC4 Gene

Selected SIMAP similar genes for KCNC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNC4: view

Variants for KCNC4 Gene

Sequence variations from dbSNP and Humsavar for KCNC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs479759 -- 110,233,233(-) TAGCA(C/T)GTGCA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs488016 -- 110,227,524(-) AGAGG(C/T)CTGAG intron-variant
rs512079 -- 110,218,398(+) CACTC(C/T)TCAGG intron-variant
rs514092 -- 110,218,661(+) TTTCA(C/G/T)TTTAT intron-variant
rs611587 -- 110,222,913(+) TGGGC(C/G)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNC4 Gene

Variant ID Type Subtype PubMed ID
esv991777 CNV Deletion 20482838

Relevant External Links for KCNC4 Gene

HapMap Linkage Disequilibrium report
KCNC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNC4 Gene

Disorders for KCNC4 Gene

Relevant External Links for KCNC4

Genetic Association Database (GAD)
KCNC4
genes like me logo Genes that share disorders with KCNC4: view

No data available for UniProtKB/Swiss-Prot for KCNC4 Gene

Publications for KCNC4 Gene

  1. Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. (PMID: 1740329) Ghanshani S. … Chandy K.G. (Genomics 1992) 2 3 23
  2. Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. (PMID: 16449802) Abbott G.W. … Goldstein S.A. (FASEB J. 2006) 3 23
  3. Cell cycle-dependent expression of Kv3.4 channels modulates proliferation of human uterine artery smooth muscle cells. (PMID: 20093253) Miguel-Velado E. … PAcrez-GarcA-a M.T. (Cardiovasc. Res. 2010) 3 23
  4. Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21. (PMID: 1920536) Rudy B. … Ward D.C. (J. Neurosci. Res. 1991) 2 3
  5. Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. (PMID: 7993631) Covarrubias M. … Vyas T.B. (Neuron 1994) 3 4

Products for KCNC4 Gene

Sources for KCNC4 Gene

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