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KCNC3 Gene

protein-coding GIFtS: 62

GC19M055510

potassium voltage-gated channel, Shaw-related subfamily, member 3
(Previous name: spinocerebellar ataxia 13 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SCA13)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KSHIIID ^², ³
KV3.3 ^²
Kv3.3 ^¹
SCA13 ^², ⁵

Descriptions
Shaw-related voltage-gated potassium channel protein 3 ^²
Voltage-gated potassium channel subunit Kv3.3 ^³
potassium voltage-gated channel, Shaw-related subfamily, member 3 ^²
spinocerebellar ataxia 13 ^¹
voltage-gated potassium channel protein KV3.3 ^²

External Ids
HGNC: 6235¹
Entrez Gene: 3748²
UniProtKB: Q14003³
Ensembl: ENSG00000131398⁷

Search outside databases for aliases for KCNC3 gene

Previous GC identifers: GC19M051447 GC19M051180 GC19M055494

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for KCNC3:

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is

comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these

subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed

rectifier class of channel proteins and is an integral membrane protein that mediates the

voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNC3_HUMAN, Q14003

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable

membranes. Assuming opened or closed conformations in response to the voltage difference across

the membrane, the protein forms a potassium-selective channel through which potassium ions may

pass in accordance with their electrochemical gradient

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNC3 gene

Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33

KCNC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M055510: (about GC identifiers)

Start:	55,507,006 bp from pter
End:	55,524,446 bp from pter
Size:	17,441 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNC3_HUMAN, Q14003 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily C member 3

Size: 757 amino acids; 80578 Da

Subunit: Heterotetramer of potassium channel proteins (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004968.2

ENSEMBL proteins:

ENSP00000375694 ENSP00000366158 ENSP00000303282

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNC3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNC3)
	Human Recombinant Proteins from Abnova (KCNC3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	1740329
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNC3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNC3
	Sigma-Aldrich Antibodies for KCNC3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNC3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNC3)
	Novus Biologicals Antibodies for KCNC3

Assays for KCNC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14003

ProtoNet protein and cluster: Q14003

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003974 Shaw voltage-gated K+ channel family signature

IPB005404 Kv3.3 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNC3_HUMAN, Q14003

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Domain: The tail may be important in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Similarity: Belongs to the potassium channel family. C (Shaw) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNC3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004977

Applied Biosystems Silencer® siRNAs for KCNC3

Sigma-Aldrich siRNA and siRNA Panels for KCNC3

Sigma-Aldrich shRNA Panels and shRNA for KCNC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of KCNC3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004977
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004977
untagged cDNA clone in CMV expression vector: NM_004977

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004977

UniProtKB/Swiss-Prot: KCNC3_HUMAN, Q14003

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable

membranes. Assuming opened or closed conformations in response to the voltage difference across

the membrane, the protein forms a potassium-selective channel through which potassium ions may

pass in accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNC3:

potassium voltage-gated channel,Drosophila Shaw-related subfamily,member 3 (mouse Kv3.3 homolog)

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kcnc3):

behavior/neurological

muscle

nervous system

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	TAS	1740329
GO:0005515	protein binding	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/50 Interacting proteins for KCNC3 (ENSP00000303282³) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNH2	ENSP00000262186³	STRING (score=.978)
KCNK1	ENSP00000355580³	STRING (score=.956)
HCN2	ENSP00000251287³	STRING (score=.946)
KCNE1	ENSP00000337255³	STRING (score=.925)
KCNH1	ENSP00000271751³	STRING (score=.919)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	1740329
GO:0008219	cell death	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNC3 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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1 Novoseek chemical compound relationship for KCNC3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	51.79	3	1740329 (1), 18448641 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNC3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004977

Sigma-Aldrich siRNA and siRNA Panels for KCNC3

Sigma-Aldrich shRNA Panels and shRNA for KCNC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004977

REFSEQ mRNAs for KCNC3 gene:

NM_004977.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004977

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004977
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004977
                                 untagged cDNA clone in CMV expression vector: NM_004977

Additional cDNA sequence:

AB208930.1 AF055989.1 AK127492.1

3 DOTS entries:

DT.121420498 DT.401973 DT.92009059

21 AceView cDNA sequences:

NM_004977 AW512445 AW148990 AI014603 AI796491 AW297613 BE552476 AW173117

AK127492 AF055989 BI087729 AI346263 AI365599 CD244420 BG991639 AA767342

AA860973 BM474777 H16352 BU101932 CB152030

highest scoring ESTs for KCNC3:

AF055989 AI796491 AK127492 AW297613 NM_004977 AA767342 AA860973 AB208930 AI346263 AI365599

Unigene Cluster for KCNC3:

Potassium voltage-gated channel, Shaw-related subfamily, member 3

Hs.467146 [show with all ESTs]

Unigene Representative Sequence: AB208930

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000391818 ENST00000376959 ENST00000305523

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNC3

¹ / ² / ³

8 probe-sets matching KCNC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73697_r_at²^{, 3}	U95-E	1	1.00	1.00	0.74	1.20	AI796491	0.60	1.00	0.82	1
31341_at²^{, 3}	U95-A	2	1.00	0.97	0.88	0.81	AF055989	1.00	1.00	1.00	1
230531_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI796491	0.60	1.00	0.82	1
207600_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004977	0.60	1.00	0.82	1
243893_at²^{, 3}	U133-B	1	0.91	1.00	--	--	R19827	0.20	1.00	0.72	1
230531_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207600_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243893_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks KCNC3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCCCTTCCC

SOURCE GeneReport for Unigene cluster: Hs.467146

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNC3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Kcnc3¹	--	potassium voltage gated channel, Shaw-related subfamily, more	88.09(n) 95.98(a)	117101 NM_053997.3 NP_446449.2
mouse (Mus musculus)	Kcnc3^{1, 5}	7 (23.00 cM)⁵	potassium voltage gated channel, Shaw-related subfamily, more^{1, 5}	88.55(n)¹ 95.84(a)¹	16504¹ NM_008422.2¹ NP_032448.2¹ AI849531⁵ AW494056⁵ (see all 11)
zebrafish (Danio rerio)	LOC559096¹	--	similar to Kv3.3 potassium channel subunit	72.64(n) 76.1(a)	559096 XM_682403.2 XP_687495.2
fruit fly (Drosophila melanogaster)	Shaw³	24C1--2	potassium ion transport voltage-gated potassium more	47(a) (best of 2)	--
worm (Caenorhabditis elegans)	shw-3³	V(12975999-12978929)	potassium channel protein	44(a)	--

About this table Species with no ortholog for KCNC3

ENSEMBL Gene Tree for KCNC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNC3 gene

KCNC2² KCNC4² KCNC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/68 NCBI SNPs in KCNC3 are shown (see all 68 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9917109^1,2	C	55510692(+)	`GAATCA/CGATGA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs11882877^1,2	C	55526100(+)	`GGCTGA/GTTCGT`	1	--	ng3¹		0	--	--	--	--
--	rs2301357^1,2	F	55518381(-)	`TATTCG/ACTGGC`	1	S/S	syn¹ ese³		1		EA	1468
--	rs2301356^1,2	F	55518483(-)	`AAGACG/ATGGTC`	1	T/T	syn¹ ese³		1		EA	1478
	rs683856^1,2	A,C,F,H,O	55514220(-)	`CATTCC/AGCAAA`	1	--	int¹		20		NS MN EU EA WA	1716
	rs11880103^1,2	A,C,F,H	55519512(+)	`TCCACG/AGGTTC`	1	--	int¹		4		EU EA WA	402
	rs636567^1,2	A,C,F,H	55519597(-)	`TCTGCT/CCAGCT`	1	--	int¹		10		EA NA MN EU WA	836
	rs604871^1,2	C,F,H	55522168(-)	`AGCCCG/CTTTCC`	1	--	int¹		9		MN EU EA WA	1016
--	rs1559134^1,2	A,F,O	55512571(-)	`CATCAT/CGCATT`	1	--	int¹		1		MN	184
	rs1559133^1,2	C,F,H	55512607(-)	`taaacG/Atgaag`	1	--	int¹		10		NS MN EU EA WA	684

About this table

HapMap Linkage Disequilibrium images for KCNC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176264 disorders: 605259

UniProtKB/Swiss-Prot: KCNC3_HUMAN, Q14003

Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259].

Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar

disorders. Patients show progressive incoordination of gait and often poor coordination of hands,

speech and eye movements, due to degeneration of the cerebellum with variable involvement of the

brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized

by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental

retardation can be present in some patients

GeneTests: KCNC3

Spinocerebellar Ataxia Type13

Human Gene Mutation Database: KCNC3
Human Genome Epidemiology Navigator: KCNC3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/12 PubMed articles for KCNC3 gene (see all 12 ):

Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. (PubMed id 1740329)^{1, 2, 3} Ghanshani S....Chandy K.G. (1992)
Localization of Shaw-related K+ channel genes on mouse and human chromosomes. (PubMed id 8111118)^{1, 2, 3} Haas M....Rudy B. (1993)
Kv3.3 potassium channels in lens epithelium and corneal endothelium. (PubMed id 10712820)^{1, 3, 4} Rae J.L. and Shepard A.R. (2000)
Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental nervous system phenotypes. (PubMed id 16501573)^{3, 4} Waters M.F.... Pulst S.M. (2006)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
Sca13. (PubMed id 18592334)³ Waters M.F. and Pulst S.M. (2008)
Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. (PubMed id 15148151)³ Brusco A....Taroni F. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)⁴ Grimwood J.... Lucas S.M. (2004)
Mapping of spinocerebellar ataxia 13 to chromosome 19q13.3-q13.4 in a family with autosomal dominant cerebellar ataxia and mental retardation. (PubMed id 10820125)³ Herman-Bert A....Brice A. (2000)
NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. (PubMed id 8917565)³ Wang D....Cutz E. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3748	HGNC: 6235	AceView: KCNC3	Ensembl:ENSG00000131398	euGenes: HUgn3748
ECgene: KCNC3	H-InvDB: KCNC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=KCNC3

Licensable Technologies for KCNC3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KCNC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNC3		Antibodies for KCNC3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNC3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for KCNC3

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Antibodies for KCNC3

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KCNC3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for KCNC3

Summaries
for KCNC3

Genomic Location
for KCNC3

Proteins
for KCNC3

Protein Domains/
Families
for KCNC3

Gene Function
for KCNC3

Pathways & Interactions
for KCNC3

Drugs & Compounds
for KCNC3

Transcripts
for KCNC3

Expression
for KCNC3

Orthologs
for KCNC3

Paralogs
for KCNC3

SNPs/Variants
for KCNC3

Disorders & Mutations
for KCNC3

Medical News
for KCNC3

Publications
for KCNC3

Search for KCNC3

Genome Databases showing KCNC3

Other Databases showing KCNC3

Specialized Databases showing KCNC3

Licensable Technologies
for KCNC3

Services
for KCNC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNC3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor KCNC3

Summariesfor KCNC3

Genomic Locationfor KCNC3

Proteinsfor KCNC3

Protein Domains/Familiesfor KCNC3

Gene Functionfor KCNC3

Pathways & Interactionsfor KCNC3

Drugs & Compoundsfor KCNC3

Transcriptsfor KCNC3

Expression for KCNC3

Orthologsfor KCNC3

Paralogsfor KCNC3

SNPs/Variantsfor KCNC3

Disorders & Mutationsfor KCNC3

Medical Newsfor KCNC3

Publicationsfor KCNC3

Search for KCNC3

Genome Databases showing KCNC3

Other Databases showing KCNC3

Specialized Databases showing KCNC3

Licensable Technologiesfor KCNC3

Servicesfor KCNC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNC3

Summaries
for KCNC3

Genomic Location
for KCNC3

Proteins
for KCNC3

Protein Domains/
Families
for KCNC3

Gene Function
for KCNC3

Pathways & Interactions
for KCNC3

Drugs & Compounds
for KCNC3

Transcripts
for KCNC3

Expression
for KCNC3

Orthologs
for KCNC3

Paralogs
for KCNC3

SNPs/Variants
for KCNC3

Disorders & Mutations
for KCNC3

Medical News
for KCNC3

Publications
for KCNC3

Licensable Technologies
for KCNC3

Services
for KCNC3