Aliases for KCNC2 Gene
External Ids for KCNC2 Gene
Previous GeneCards Identifiers for KCNC2 Gene
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for KCNC2 Gene
KCNC2 (Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.
UniProtKB/Swiss-Prot for KCNC2 Gene
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.