Aliases for KCNC1 Gene
- Potassium Voltage-Gated Channel Subfamily C Member 1 2 3
- Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 1 2 3 5
- Voltage-Gated Potassium Channel Subunit Kv4 3 4
- NGK2 3 4
- Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 2
- Voltage-Gated Potassium Channel Protein KV3.1 3
External Ids for KCNC1 Gene
Previous GeneCards Identifiers for KCNC1 Gene
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]
GeneCards Summary for KCNC1 Gene
KCNC1 (Potassium Voltage-Gated Channel Subfamily C Member 1) is a Protein Coding gene. Diseases associated with KCNC1 include epilepsy, progressive myoclonic 7 and spinocerebellar ataxia 13. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.
UniProtKB/Swiss-Prot for KCNC1 Gene
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.