KCNB2 Gene

Aliases
for KCNB2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC08P072532 GC08P073420 GC08P073172 GC08P073612 GC08P068946

Summaries
for KCNB2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for KCNB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000008.10  NT_008183.20  NC_018919.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNB2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNB2

KCNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P073499:  view genomic region     (about GC identifiers)

Proteins
for KCNB2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for KCNB2: NX_Q92953

Explore proteomics data for KCNB2 at MOPED

Post-translational modifications: 

KCNB2 Human Recombinant Protein Products:

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Domains /
Families
for KCNB2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q92953

Find genes that share domains with KCNB2           About GenesLikeMe

Function
for KCNB2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Kcnb2)

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		Selected qRT-PCR Assays for microRNAs that regulate KCNB2 (see all 9):
		hsa-miR-1206 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-491-3p hsa-miR-3658 hsa-miR-1208 hsa-miR-3143
		SwitchGear 3'UTR luciferase reporter plasmid: KCNB2 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

Localization
for KCNB2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
cytosol	1
nucleus	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for KCNB2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for KCNB2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Potassium Channels	Potassium Channels 0.43 Voltage gated Potassium channels 0.43
2	Transmission across Chemical Synapses	Neuronal System 0.68
3	Dopamine-DARPP32 Feedback onto cAMP Pathway	Dopamine-DARPP32 Feedback onto cAMP Pathway

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNB2

Dopamine-DARPP32 Feedback onto cAMP Pathway

1 Reactome Pathway for KCNB2

Voltage gated Potassium channels

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for KCNB2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for KCNB2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for KCNB2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACAGTTTAG

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCNB2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNB2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

Orthologs
for KCNB2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for KCNB2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for KCNB2 gene

KCNF1²  KCNG3²  KCNV1²  KCNG2²  KCNS2²  KCNS3²  KCNB1²  KCNV2²  

KCNG4²  KCNG1²  KCNS1²  

Selected SIMAP similar genes for KCNB2 using alignment to 1 protein entry:     KCNB2_HUMAN(see all similar genes):

KCNB1    KCNS3    KCNS2    KCNF1    KCNG1    KCNG2

KCNV1    KCNV2    KCND1    KCNG4    KCNS1    KCNA1

KCNG3    KCNA10    KCNA2    KCNA4    KCNC1    KCNA5

Find genes that share paralogs with KCNB2           About GenesLikeMe

Genomic Variants
for KCNB2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCNB2 (see all 7585)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0357744		A colorectal cancer sample4	--	see VAR_035774	2	V I	mis4		0	--	--	--	--
rs2004723841,2	C	untested1	73849507(+)	CCAGGA/G/TACAGA	2	G	syn1		0	--	--	--	--
rs736860661,2	C	--	73447646(+)	ACAACA/CACCAA	1	--	us2k1		2		WA	120
rs1122157651,2	F	--	73447650(+)	CAACCA/CAAACA	1	--	us2k1		2		CSA WA	119
rs1146392541,2	C,F	--	73447661(+)	AAACAA/GAAACC	1	--	us2k1		1		WA	118
rs1876521101,2		--	73447751(+)	AGAGAA/GGATAG	1	--	us2k1		0	--	--	--	--
rs1913610191,2		--	73447804(+)	ACATGA/GAGTAT	1	--	us2k1		0	--	--	--	--
rs3493361,2	C,A	--	73448053(-)	gtgatA/Gttccc	1	--	us2k1		0	--	--	--	--
rs284070271,2	C	--	73448080(+)	TGGGGC/TGGGGG	1	--	us2k1		1		NA	2
rs1435880361,2		--	73448192(+)	ACATGC/TACCCT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNB2 (73449626 - 73699626 bp, first 250kb of KCNB2)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for KCNB2 (see all 35):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2673987	CNV	Deletion	23128226
esv2737160	CNV	Deletion	23290073
nsv436585	CNV	Deletion	17901297
esv4538	CNV	Deletion	18987735
esv1664475	CNV	Deletion	17803354
dgv186e180	CNV	Deletion	20482838
esv2497261	CNV	Deletion	19546169
esv2272208	CNV	Deletion	18987734
esv2737154	CNV	Deletion	23290073
esv269210	CNV	Insertion	20981092

Human Gene Mutation Database (HGMD): KCNB2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KCNB2

DNA2.0 Custom Variant and Variant Library Synthesis for KCNB2

Disorders / Diseases
for KCNB2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for KCNB2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNB2 gene, integrated from 10 sources (see all 18): (articles sorted by number of sources associating them with KCNB2)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PubMed id 9612272)^{1, 2, 3, 9} Schmalz F.... Horowitz B. (Am. J. Physiol. 1998)
2. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)^{1, 4, 9} Nyholt D.R....Palotie A. (Hum. Mol. Genet. 2008)
3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
4. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)^{1, 4} Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)^{1, 4} Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)
6. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)^{1, 4} Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
7. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
8. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (PLoS Genet. 2012)
9. Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle. (PubMed id 22422395)¹ Hristov K.L....Petkov G.V. (Am. J. Physiol., Cell Physiol. 2012)
10. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PubMed id 19074135)¹ Mederos Y Schnitzler M.... Preisig-Muller R. (J. Biol. Chem. 2009)

External Searches for KCNB2 gene

Genome Databases showing KCNB2 gene

Other Databases showing KCNB2 gene

Specialized Databases showing KCNB2 gene

Products
for KCNB2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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