KCNB2 Gene
protein-coding GIFtS: 61
GCID: GC08P073499
|
|
potassium voltage-gated channel, Shab-related subfamily,...
| |
Aliases
for KCNB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 21 2 | | Delayed Rectifier Potassium Channel Protein2 | | Voltage-Gated Potassium Channel Subunit Kv2.22 3 | | Potassium Channel Kv2.22 | | KV2.22 5 | | Potassium Voltage-Gated Channel Subfamily B Member 22 | | Kv2.21 | | |
Export aliases for KCNB2 gene to outside databasesPrevious GC identifers: GC08P072532 GC08P073420 GC08P073172 GC08P073612 GC08P068946 |
Summaries
for KCNB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNB2:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from bothfunctional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heartrate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cellvolume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified inDrosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed ingastrointestinal smooth muscle cells. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close inresponse to the voltage difference across the membrane, letting potassium ions pass in accordance with theirelectrochemical gradient
 summary
for KCNB2:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNB2
|
Genomic Views
for KCNB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNB2 gene promoter:
AhR E2F-4 E2F-3a E2F-5 GATA-3 E2F-2 RORalpha2 Arnt E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.2 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.2KCNB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P073499: view genomic region
(about GC identifiers)
Start:
|
73,449,626 bp from pter |
End:
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73,850,584 bp from pter |
Size:
|
400,959 bases |
Orientation:
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plus strand |
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Proteins
for KCNB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily B member 2 Size: 911 amino acids; 102563 Da
Subunit: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAB08433.1; Type=Frameshift; Positions=768;
Secondary accessions: Q7Z7D0 Q9BXD3Explore the universe of human proteins at neXtProt for KCNB2: NX_Q92953
Post-translational modifications:
Phosphorylated (Potential)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92953
KCNB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004761.2
ENSEMBL proteins: ENSP00000430846 Reactome Protein details: Q92953
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0043025 | neuronal cell body |
-- | -- |
KCNB2 for ontologies About GeneDecksing
KCNB2 Antibody Products:
Assay Products for KCNB2: |
Protein
Domains /
Families
for KCNB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNB2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92953ProtoNet protein and cluster: Q92953 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB005826 Kv2.2 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third positionDomain: The tail may be important in modulation of channel activity and/or targeting of the channel to specificsubcellular compartmentsSimilarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily |
Function
for KCNB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close inresponse to the voltage difference across the membrane, letting potassium ions pass in accordance with theirelectrochemical gradient Genatlas biochemistry entry for KCNB2:potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinalsmooth muscles
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005251 | delayed rectifier potassium channel activity |
TAS | 9612272 |
KCNB2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Kcnb2tm1Lex for KCNB2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Kcnb2):
KCNB2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 3 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KCNB2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNB2
3 
Reactome Pathways for KCNB2
KCNB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNB2
2 Interacting proteins for KCNB2 (Q929533) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
KCNB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for KCNB2 available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about KCNB2
|
Transcripts
for KCNB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNB2 gene: NM_004770.2 Unigene Cluster for KCNB2: Potassium voltage-gated channel, Shab-related subfamily, member 2 Hs.661102 [show with all ESTs]Unigene Representative Sequence: AF3387301 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000523207(uc003xzb.3)
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCNB2 (NM_004770) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF338730.1 AF450111.1 AK311263.1 U69962.1 1 DOTS entry: DT.92033542 5 AceView cDNA sequences: AF338730 NM_004770 AF450111 U69962 CK004440
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNB2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | |
ECgene alternative splicing isoforms for KCNB2
|
Expression
for KCNB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGTTTAG
About this image
See KCNB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNB2
SOURCE GeneReport for Unigene cluster: Hs.661102
SABiosciences Expression via Pathway-Focused PCR Array including KCNB2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNB2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2 |
Orthologs
for KCNB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNB2 gene from 4/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNB21 |
potassium voltage-gated channel, Shab-related subfamily, more |
77.92(n)
82.4(a) |
|
431181 XM_003640825.1 XP_003640873.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
kcnb2-B2 |
potassium voltage-gated channel, Shab-related subfamily, more |
76.23(n) |
|
U20342.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5668831 |
potassium voltage-gated channel subfamily B member more |
64.74(n)
69.94(a) |
|
566883 XM_690167.3 XP_695259.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Shab3 |
potassium ion transport voltage-gated
potassium more |
68(a) |
|
-- |
ENSEMBL Gene Tree for KCNB2 (if available)
TreeFam Gene Tree for KCNB2 (if available) |
Paralogs
for KCNB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNB2 gene
- KCNG32 KCNF12 KCNV12 KCNG22 KCNS22 KCNS32 KCNB12 KCNV22
- KCNG42 KCNG12 KCNS12
18/23 SIMAP similar genes for KCNB2 using alignment to 1 protein entry: KCNB2_HUMAN(see all similar genes):KCNB1 KCNS3 KCNS2 KCNF1 KCNG1 KCNG2
KCNV1 KCNV2 KCND1 KCNG4 KCNS1 KCNA1
KCNG3 KCNA10 KCNA2 KCNA4 KCNC1 KCNA5
KCNB2 for paralogs About GeneDecksing
|
Genomic Variants
for KCNB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNB2 (73449626 - 73699626 bp, first 250kb of KCNB2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for KCNB2
10 CNVs: 100387 1792 44358 23878 7706 36863 43609 6635 22682 39528
1 Indel: 11329
Human Gene Mutation Database (HGMD): KCNB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNB2 |
|
Disorders
/ Diseases
for KCNB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNB2 for disorders About GeneDecksing
OMIM gene information: 607738
OMIM disorders: --
4  diseases for KCNB2: About MalaCardsneuronitis migraine multiple sclerosis pancreatitis
Human Genome Epidemiology (HuGE) Navigator: KCNB2 (4 documents)
Export disorders for KCNB2 gene to outside databases
|
Publications
for KCNB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNB2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with KCNB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PubMed id 9612272)1, 2, 3, 9 Schmalz F.... Horowitz B. (1998)
- International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
- A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)1, 9 Nyholt D.R....Palotie A. (2008)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Expression and function of K(V)2-containing channels i n human urinary bladder smooth muscle. (PubMed id 22422395)1 Hristov K.L....Petkov G.V. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1 Cirulli E.T....Goldstein D.B. (2010)
- Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135)1 Mederos Y Schnitzler M.... Preisig-Muller R. (2009)
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1 Baranzini S.E....Oksenberg J.R. (2008)
- Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)1 Vasan R.S....Benjamin E.J. (2007)
|
External Searches for KCNB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNB2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNB2 gene:
Search GeneIP for patents involving KCNB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Tocris compounds for KCNB2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KCNB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2 |
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