Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNB2 Gene

Aliases for KCNB2 Gene

  • Potassium Channel, Voltage Gated Shab Related Subfamily B, Member 2 2 3
  • Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 2 3
  • Voltage-Gated Potassium Channel Subunit Kv2.2 3 4
  • KV2.2 3 6
  • Potassium Voltage-Gated Channel Subfamily B Member 2 3
  • Delayed Rectifier Potassium Channel Protein 3
  • Potassium Channel Kv2.2 3

External Ids for KCNB2 Gene

Summaries for KCNB2 Gene

Entrez Gene Summary for KCNB2 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNB2 Gene

KCNB2 (Potassium Channel, Voltage Gated Shab Related Subfamily B, Member 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.

UniProtKB/Swiss-Prot for KCNB2 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient

Tocris Summary for KCNB2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNB2 Gene

Genomics for KCNB2 Gene

Genomic Location for KCNB2 Gene

Start:
72,537,391 bp from pter
End:
72,938,581 bp from pter
Size:
401,191 bases
Orientation:
Plus strand

Genomic View for KCNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNB2 Gene

Regulatory Elements for KCNB2 Gene

Proteins for KCNB2 Gene

  • Protein details for KCNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92953-KCNB2_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily B member 2
    Protein Accession:
    Q92953
    Secondary Accessions:
    • Q7Z7D0
    • Q9BXD3

    Protein attributes for KCNB2 Gene

    Size:
    911 amino acids
    Molecular mass:
    102563 Da
    Quaternary structure:
    • Heteromultimer with KCNS1, KCNS2 and KCNS3.
    SequenceCaution:
    • Sequence=AAB08433.1; Type=Frameshift; Positions=768; Evidence={ECO:0000305};

neXtProt entry for KCNB2 Gene

Proteomics data for KCNB2 Gene at MOPED

Post-translational modifications for KCNB2 Gene

Other Protein References for KCNB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNB2 Gene

Domains for KCNB2 Gene

Gene Families for KCNB2 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNB2_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q92953
  • The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments:
    • Q92953
Family:
  • Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.:
    • Q92953
genes like me logo Genes that share domains with KCNB2: view

Function for KCNB2 Gene

Molecular function for KCNB2 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinal smooth muscles
UniProtKB/Swiss-Prot Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient

Gene Ontology (GO) - Molecular Function for KCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNB2: view

Phenotypes for KCNB2 Gene

MGI mutant phenotypes for KCNB2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with KCNB2: view

Animal Models for KCNB2 Gene

MGI Knock Outs for KCNB2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNB2 Gene

Localization for KCNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNB2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNB2 Gene COMPARTMENTS Subcellular localization image for KCNB2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNB2: view

Pathways for KCNB2 Gene

genes like me logo Genes that share pathways with KCNB2: view

Pathways by source for KCNB2 Gene

1 Qiagen pathway for KCNB2 Gene

Gene Ontology (GO) - Biological Process for KCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 9612272
GO:0006940 regulation of smooth muscle contraction TAS 9612272
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNB2: view

Compounds for KCNB2 Gene

(5) Tocris Compounds for KCNB2 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(3) IUPHAR Ligand for KCNB2 Gene

Ligand Type Action Affinity Pubmed IDs
quinine Inhibitor Inhibition
4-aminopyridine Inhibitor None
tetraethylammonium Inhibitor None
genes like me logo Genes that share compounds with KCNB2: view

Transcripts for KCNB2 Gene

mRNA/cDNA for KCNB2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNB2 Gene

Potassium voltage-gated channel, Shab-related subfamily, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: - - -

Relevant External Links for KCNB2 Gene

GeneLoc Exon Structure for
KCNB2
ECgene alternative splicing isoforms for
KCNB2

Expression for KCNB2 Gene

mRNA expression in normal human tissues for KCNB2 Gene

mRNA differential expression in normal tissues according to GTEx for KCNB2 Gene

This gene is overexpressed in Brain - Cortex (7.9), Brain - Frontal Cortex (BA9) (7.6), Brain - Anterior cingulate cortex (BA24) (6.4), and Brain - Hippocampus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNB2 Gene

SOURCE GeneReport for Unigene cluster for KCNB2 Gene Hs.661102

genes like me logo Genes that share expressions with KCNB2: view

Orthologs for KCNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNB2 36
  • 99.63 (n)
  • 99.89 (a)
KCNB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNB2 36
  • 86.07 (n)
  • 92.52 (a)
KCNB2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNB2 36
  • 83.58 (n)
  • 90.62 (a)
KCNB2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnb2 36
  • 87.06 (n)
  • 93.05 (a)
Kcnb2 16
Kcnb2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNB2 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNB2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnb2 36
  • 87.84 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves KCNB2 36
  • 77.92 (n)
  • 82.4 (a)
KCNB2 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNB2 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kcnb2-B 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnb2 36
  • 69.67 (n)
  • 76.4 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnb2 37
  • 65 (a)
OneToMany
KCNB2 (2 of 2) 37
  • 73 (a)
OneToMany
LOC566883 36
  • 64.89 (n)
  • 69.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shab 37
  • 25 (a)
OneToMany
Shab 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 38
  • 31 (a)
C32C4.1 38
  • 34 (a)
F44A2.2 38
  • 34 (a)
exp-2 38
  • 38 (a)
Y48A6B.6 38
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14250 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 71 (a)
OneToMany
Species with no ortholog for KCNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNB2 Gene

ENSEMBL:
Gene Tree for KCNB2 (if available)
TreeFam:
Gene Tree for KCNB2 (if available)

Paralogs for KCNB2 Gene

Paralogs for KCNB2 Gene

Selected SIMAP similar genes for KCNB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNB2: view

Variants for KCNB2 Gene

Sequence variations from dbSNP and Humsavar for KCNB2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3357 -- 72,814,516(-) AAACG(A/G)TAAAG intron-variant
rs187028 -- 72,547,278(-) aggca(A/T)gaaaa intron-variant
rs191769 -- 72,602,704(-) TGGAA(A/G)GTCAA intron-variant
rs349330 -- 72,572,990(-) GCCAC(C/T)AGCAG intron-variant
rs349331 -- 72,572,639(-) GTTCC(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNB2 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV Deletion 23290073
nsv891008 CNV Loss 21882294
nsv891009 CNV Loss 21882294
nsv6253 CNV Insertion 18451855
esv259960 OTHER Complex 20981092
nsv526000 CNV Gain 19592680
esv33951 CNV Gain 17666407
esv33601 CNV Gain 17666407
nsv527962 CNV Gain 19592680
nsv465714 CNV Gain 19166990
nsv438065 CNV Loss 16468122
nsv891010 CNV Gain 21882294
nsv465715 CNV Gain 19166990
esv2673987 CNV Deletion 23128226
esv269210 CNV Insertion 20981092
esv274654 CNV Insertion 20981092
esv259445 OTHER Complex 20981092
esv259684 OTHER Complex 20981092
esv1010570 CNV Insertion 20482838
esv1014824 CNV Insertion 17803354
nsv396083 CNV Insertion 16902084
nsv6255 CNV Loss 18451855
esv2497261 CNV Deletion 19546169
nsv436585 CNV Deletion 17901297
nsv512053 CNV Loss 21212237
esv2272208 CNV Deletion 18987734
dgv186e180 CNV Deletion 20482838
esv2737160 CNV Deletion 23290073
esv4538 CNV Deletion 18987735
nsv499484 CNV Loss 21111241
nsv398337 CNV Loss 16902084
esv1664475 CNV Deletion 17803354
nsv831354 CNV Gain 17160897
esv275110 CNV Gain+Loss 21479260
esv994308 CNV Loss 20482838

Relevant External Links for KCNB2 Gene

HapMap Linkage Disequilibrium report
KCNB2
Human Gene Mutation Database (HGMD)
KCNB2

Disorders for KCNB2 Gene

Relevant External Links for KCNB2

Genetic Association Database (GAD)
KCNB2
Human Genome Epidemiology (HuGE) Navigator
KCNB2
genes like me logo Genes that share disorders with KCNB2: view

No data available for UniProtKB/Swiss-Prot for KCNB2 Gene

Publications for KCNB2 Gene

  1. Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PMID: 9612272) Schmalz F. … Horowitz B. (Am. J. Physiol. 1998) 2 3 4 23
  2. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 23 49
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  4. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for KCNB2 Gene

Sources for KCNB2 Gene

Back to Top

Content