Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNB2 Gene

protein-coding GIFtS: 62
GCID: GC08P073499

Potassium Voltage-Gated Channel, Shab-Related Subfamily,...

5 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2¹ ²
Voltage-Gated Potassium Channel Subunit Kv2.2² ³
KV2.2² ⁵
Delayed Rectifier Potassium Channel Protein²
Potassium Channel Kv2.2²
Potassium Voltage-Gated Channel Subfamily B Member 2²

External Ids:	HGNC: 6232¹	Entrez Gene: 9312²	Ensembl: ENSG00000182674⁷	OMIM: 607738⁵	UniProtKB: Q92953³

Export aliases for KCNB2 gene to outside databases

Previous GC identifers: GC08P072532 GC08P073420 GC08P073172 GC08P073612 GC08P068946

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNB2 Gene:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart

rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell

volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in

Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,

voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in

gastrointestinal smooth muscle cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNB2 Gene:

KCNB2 (potassium voltage-gated channel, Shab-related subfamily, member 2) is a protein-coding gene. Diseases associated with KCNB2 include migraine, and crohn's disease, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in

response to the voltage difference across the membrane, letting potassium ions pass in accordance with their

electrochemical gradient

summary for KCNB2 Gene:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNB2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.2 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNB2 gene promoter:
AhR E2F-4 E2F-3a E2F-5 GATA-3 E2F-2 RORalpha2 Arnt E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNB2 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.2 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.2

KCNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNB2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P073499: view genomic region (about GC identifiers)

Start:	73,449,626 bp from pter	End:	73,850,584 bp from pter
Size:	400,959 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily B member 2

Size: 911 amino acids; 102563 Da

Subunit: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAB08433.1; Type=Frameshift; Positions=768;

Secondary accessions: Q7Z7D0 Q9BXD3

Explore the universe of human proteins at neXtProt for KCNB2: NX_Q92953

Explore proteomics data for KCNB2 at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated (Potential)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q92953

KCNB2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_004761.2

ENSEMBL proteins:

ENSP00000430846

Reactome Protein details: Q92953
Human Recombinant Protein Products for KCNB2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for KCNB2
	GenScript Custom Purified and Recombinant Proteins Services for KCNB2
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for KCNB2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0016020	membrane	--	--

KCNB2 for ontologies About GeneDecksing

KCNB2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KCNB2 (Potassium Channel Kv2.2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCNB2
	GenScript Custom Superior Antibodies Services for KCNB2
	Novus Biologicals KCNB2 Antibodies
	Abcam antibodies for KCNB2
	Cloud-Clone Corp. Antibodies for KCNB2
	Search ThermoFisher Antibodies for KCNB2
	LSBio Antibodies in human, mouse, rat for KCNB2

Assay Products for KCNB2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KCNB2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNB2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KCNB2 Cloud-Clone Corp. CLIAs for KCNB2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

KCN: Potassium channels

Kv: Voltage-gated ion channels / Potassium channels

IUPHAR Guide to PHARMACOLOGY protein family classification: K_v2.2

Voltage-gated potassium channels

5/8 InterPro protein domains (see all 8):

IPR005821 Ion_trans_dom

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003973 K_chnl_volt-dep_Kv2

IPR005826 K_chnl_volt-dep_Kv2.2

Graphical View of Domain Structure for InterPro Entry Q92953

ProtoNet protein and cluster: Q92953

3 Blocks protein domains:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB005826 Kv2.2 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Domain: The tail may be important in modulation of channel activity and/or targeting of the channel to specific

subcellular compartments

Similarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily

KCNB2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KCNB2_HUMAN, Q92953

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in

response to the voltage difference across the membrane, letting potassium ions pass in accordance with their

electrochemical gradient

Genatlas biochemistry entry for KCNB2:

potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinal

smooth muscles

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005249	voltage-gated potassium channel activity	--	--
GO:0005251	delayed rectifier potassium channel activity	TAS	9612272
GO:0005515	protein binding	--	--

KCNB2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnb2):

behavior/neurological

KCNB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Kcnb2^tm1Lex for KCNB2

inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNB2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNB2

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNB2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNB2 (see all 9):
		hsa-miR-1206 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-491-3p hsa-miR-3658 hsa-miR-1208 hsa-miR-3143

		SwitchGear 3'UTR luciferase reporter plasmid: KCNB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KCNB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB2
		Sirion Biotech Custom design and validation of potent shRNA sequences against KCNB2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KCNB2
			Sirion Biotech Customized adenovirus for overexpression of KCNB2 Customized adenovirus for potent knockdown of KCNB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for KCNB2 (see all 6) OriGene ORF clones in mouse, rat for KCNB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNB2 (NM_004770)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNB2
		Search LifeMap BioReagents cell lines for KCNB2
		Sirion Biotech Customized stable knockdown cell line services for KCNB2 Customized inducible knockdown cell line services for KCNB2 Customized stable overexpressing cell line services for KCNB2 Customized inducible overexpressing cell line services for KCNB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KCNB2 About

See pathways by source

SuperPath

Contained pathways About

Potassium Channels

	Potassium Channels	0.43			Potassium transporters: outward current	0.42
	Voltage gated Potassium channels	0.43

Transmission across Chemical Synapses

Neuronal System

0.67

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for KCNB2

Potassium transporters- outward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNB2

Dopamine-DARPP32 Feedback onto cAMP Pathway

3 Reactome Pathways for KCNB2

	Potassium Channels
	Neuronal System
	Voltage gated Potassium channels

KCNB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNB2

2 Interacting proteins for KCNB2 (Q92953³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993³	I2D: score=1
KCNV1	Q6PIU1³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	--	--
GO:0006813	potassium ion transport	TAS	9612272
GO:0006940	regulation of smooth muscle contraction	TAS	9612272
GO:0007268	synaptic transmission	TAS	--
GO:0051260	protein homooligomerization	IEA	--

KCNB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
ICA 110381	KV7.2/7.3 activator; displays anticonvulsant properties	[325457-99-6]
XE 991 dihydrochloride	Potent, selective KV7 (KCNQ) channel blocker; blocks M-current	[122955-42-4]
JNJ 303	Potent and selective IKs blocker	[878489-28-2]
E-4031 dihydrochloride	KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)	[113559-13-0]
ShK-Dap22	Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro	[220384-25-8]

3 IUPHAR Ligands for KCNB2 (K_v2.2) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
quinine	Pore Blocker	None	4.9	9612272
4-aminopyridine	Pore Blocker	None	2.8	9612272
tetraethylammonium	Pore Blocker	None	2.6	9612272

Search CenterWatch for drugs/clinical trials and news about KCNB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNB2 gene:

NM_004770.2

Unigene Cluster for KCNB2:

Potassium voltage-gated channel, Shab-related subfamily, member 2

Hs.661102 [show with all ESTs]

Unigene Representative Sequence: AF338730

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000523207(uc003xzb.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNB2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNB2 (see all 9):
		hsa-miR-1206 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-491-3p hsa-miR-3658 hsa-miR-1208 hsa-miR-3143

		SwitchGear 3'UTR luciferase reporter plasmid: KCNB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KCNB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB2
		Sirion Biotech Custom design and validation of potent shRNA sequences against KCNB2

Clone Products:		OriGene clones in human, mouse for KCNB2 (see all 6) OriGene ORF clones in mouse, rat for KCNB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNB2 (NM_004770)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCNB2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB2

Additional mRNA sequence:

AF338730.1 AF450111.1 AK311263.1 U69962.1

1 DOTS entry:

DT.92033542

5 AceView cDNA sequences:

AF338730 NM_004770 AF450111 U69962 CK004440

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNB2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5
SP1:
SP2:			-		-		-

ECgene alternative splicing isoforms for KCNB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACAGTTTAG

About this image

See KCNB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNB2

SOURCE GeneReport for Unigene cluster: Hs.661102

SABiosciences Expression via Pathway-Focused PCR Array including KCNB2:

Neuronal Ion Channels in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCNB2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNB2 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kcnb2^{1 , 5}	potassium voltage gated channel, Shab-related subfamily, more^{1, 5}	87.06(n)¹ 93.05(a)¹		1 (4.50 cM)⁵ 98741¹ NM_001098528.2¹ NP_001091998.1¹ 15287259⁵
chicken (Gallus gallus)	Aves	KCNB2¹	potassium voltage-gated channel, Shab-related subfamily, more	77.92(n) 82.4(a)		431181 XM_003640825.1 XP_003640873.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	82(a) 81(a)	possible ortholog possible ortholog	4(146785839-146787137) 4(33183548-33358294)
African clawed frog (Xenopus laevis)	Amphibia	kcnb2-B²	potassium voltage-gated channel, Shab-related subfamily, more	76.23(n)		U20342.1
zebrafish (Danio rerio)	Actinopterygii	LOC566883¹	potassium voltage-gated channel subfamily B member more	64.74(n) 69.94(a)		566883 XM_690167.3 XP_695259.3
fruit fly (Drosophila melanogaster)	Insecta	Shab³	potassium ion transport voltage-gated potassium more	68(a)		--

ENSEMBL Gene Tree for KCNB2 (if available)
TreeFam Gene Tree for KCNB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNB2 gene

KCNF1² KCNG3² KCNV1² KCNG2² KCNS2² KCNS3² KCNB1² KCNV2²

KCNG4² KCNG1² KCNS1²

18/23 SIMAP similar genes for KCNB2 using alignment to 1 protein entry: KCNB2_HUMAN(see all similar genes):

KCNB1 KCNS3 KCNS2 KCNF1 KCNG1 KCNG2

KCNV1 KCNV2 KCND1 KCNG4 KCNS1 KCNA1

KCNG3 KCNA10 KCNA2 KCNA4 KCNC1 KCNA5

KCNB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_035774⁴		A colorectal cancer sample⁴	--	see VAR_035774	2	V I	mis⁴		0	--	--	--	--
rs200472384^1,2	C	untested¹	73849507(+)	`CCAGGA/G/TACAGA`	2	G	syn¹		0	--	--	--	--
rs73686066^1,2	C	--	73447646(+)	`ACAACA/CACCAA`	1	--	us2k¹		2		WA	120
rs112215765^1,2	F	--	73447650(+)	`CAACCA/CAAACA`	1	--	us2k¹		2		CSA WA	119
rs114639254^1,2	C,F	--	73447661(+)	`AAACAA/GAAACC`	1	--	us2k¹		1		WA	118
rs187652110^1,2		--	73447751(+)	`AGAGAA/GGATAG`	1	--	us2k¹		0	--	--	--	--
rs191361019^1,2		--	73447804(+)	`ACATGA/GAGTAT`	1	--	us2k¹		0	--	--	--	--
rs349336^1,2	C,A	--	73448053(-)	`gtgatA/Gttccc`	1	--	us2k¹		0	--	--	--	--
rs28407027^1,2	C	--	73448080(+)	`TGGGGC/TGGGGG`	1	--	us2k¹		1		NA	2
rs143588036^1,2		--	73448192(+)	`ACATGC/TACCCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNB2 (73449626 - 73699626 bp, first 250kb of KCNB2)

Structural Variations
Database of Genomic Variants (DGV) 10/35 variations for KCNB2 (see all 35): About this table

Variant ID	Type	Subtype	PubMed ID
esv2673987	CNV	Deletion	23128226
esv2737160	CNV	Deletion	23290073
nsv436585	CNV	Deletion	17901297
esv4538	CNV	Deletion	18987735
esv1664475	CNV	Deletion	17803354
dgv186e180	CNV	Deletion	20482838
esv2497261	CNV	Deletion	19546169
esv2272208	CNV	Deletion	18987734
esv2737154	CNV	Deletion	23290073
esv269210	CNV	Insertion	20981092

Human Gene Mutation Database (HGMD): KCNB2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNB2

DNA2.0 Custom Variant and Variant Library Synthesis for KCNB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNB2 for disorders           About GeneDecksing

OMIM gene information: 607738    OMIM disorders: --

5 diseases for KCNB2:    About MalaCards

migraine crohn's disease neuronitis pancreatitis

endotheliitis

Genetic Association Database (GAD): KCNB2
Human Genome Epidemiology (HuGE) Navigator: KCNB2 (4 documents)

Export disorders for KCNB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNB2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with KCNB2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PubMed id 9612272)^{1, 2, 3, 9} Schmalz F.... Horowitz B. (1998)
A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)^{1, 4, 9} Nyholt D.R....Palotie A. (2008)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)^{1, 4} Cirulli E.T....Goldstein D.B. (2010)
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)^{1, 4} Baranzini S.E....Oksenberg J.R. (2008)
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)^{1, 4} Vasan R.S....Benjamin E.J. (2007)
International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (2005)
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (2012)
Expression and function of K(V)2-containing channels i n human urinary bladder smooth muscle. (PubMed id 22422395)¹ Hristov K.L....Petkov G.V. (2012)
Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135)¹ Mederos Y Schnitzler M.... Preisig-Muller R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9312	HGNC: 6232	AceView: KCNB2	Ensembl:ENSG00000182674	euGenes: HUgn9312
ECgene: KCNB2	H-InvDB: KCNB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNB2 gene:
Search GeneIP for patents involving KCNB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for KCNB2 (Potassium Channel Kv2.2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for KCNB2
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for KCNB2
	OriGene qSTAR qPCR primer pairs in human, mouse for KCNB2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for KCNB2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCNB2		OriGene Custom Protein Services for KCNB2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNB2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNB2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNB2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB2

	GenScript Custom Purified and Recombinant Proteins Services for KCNB2		GenScript cDNA clones with any tag delivered in your preferred vector for KCNB2
	GenScript Custom Assay Services for KCNB2		GenScript Custom Superior Antibodies Services for KCNB2
	GenScript Custom overexpressing Cell Line Services for KCNB2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNB2 promoter
	Search Chromatin IP Primers for KCNB2
	RT² qPCR Primer Assay in human, mouse, rat KCNB2
	GNC Network for KCNB2
	SABiosciences PCR Arrays including human, mouse, rat KCNB2

Tocris compounds for KCNB2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCNB2 antibodies

	Antibodies for KCNB2
	See all of Abcam's Antibodies, Kits and Proteins for KCNB2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for KCNB2
	Antibodies for KCNB2
	ELISAs for KCNB2
	CLIAs for KCNB2

Search LifeMap BioReagents cell lines for KCNB2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

	SwitchGear 3'UTR luciferase reporter plasmids for KCNB2
	SwitchGear Promoter luciferase reporter plasmids for KCNB2

Search ThermoFisher Antibodies for KCNB2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNB2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNB2

Customized:

	stable knockdown cell line services for KCNB2
	inducible knockdown cell line services for KCNB2
	design and validation of potent shRNA sequences against KCNB2
	adenovirus for potent knockdown of KCNB2
	stable overexpressing cell line services for KCNB2
	inducible overexpressing cell line services for KCNB2
	adenovirus for overexpression of KCNB2

LSBio Antibodies in human, mouse, rat for KCNB2

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCNB2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

KCNB2 Gene

Potassium Voltage-Gated Channel, Shab-Related Subfamily,...

Aliases
for KCNB2 gene

Summaries
for KCNB2 gene

Genomic Views
for KCNB2 gene

Proteins
for KCNB2 gene

Protein Domains /
Families
for KCNB2 gene

Function
for KCNB2 gene

Pathways & Interactions
for KCNB2 gene

Drugs & Compounds
for KCNB2 gene

Transcripts
for KCNB2 gene

Expression
for KCNB2 gene

Orthologs
for KCNB2 gene

Paralogs
for KCNB2 gene

Genomic Variants
for KCNB2 gene

Disorders / Diseases
for KCNB2 gene

Publications
for KCNB2 gene

External Searches for KCNB2 gene

Genome Databases showing KCNB2 gene

Other Databases showing KCNB2 gene

Specialized Databases showing KCNB2 gene

Intellectual Property
for KCNB2 gene

Products
for KCNB2 gene

View Random Gene

Advanced Search

Export list of displayed genes

KCNB2 Gene

Potassium Voltage-Gated Channel, Shab-Related Subfamily,...

Aliasesfor KCNB2 gene

Summariesfor KCNB2 gene

Genomic Viewsfor KCNB2 gene

Proteinsfor KCNB2 gene

Protein Domains /Familiesfor KCNB2 gene

Functionfor KCNB2 gene

Pathways & Interactionsfor KCNB2 gene

Drugs & Compoundsfor KCNB2 gene

Transcriptsfor KCNB2 gene

Expression for KCNB2 gene

Orthologsfor KCNB2 gene

Paralogsfor KCNB2 gene

Genomic Variantsfor KCNB2 gene

Disorders / Diseasesfor KCNB2 gene

Publicationsfor KCNB2 gene

External Searches for KCNB2 gene

Genome Databases showing KCNB2 gene

Other Databases showing KCNB2 gene

Specialized Databases showing KCNB2 gene

Intellectual Propertyfor KCNB2 gene

Productsfor KCNB2 gene

View Random Gene

Aliases
for KCNB2 gene

Summaries
for KCNB2 gene

Genomic Views
for KCNB2 gene

Proteins
for KCNB2 gene

Protein Domains /
Families
for KCNB2 gene

Function
for KCNB2 gene

Pathways & Interactions
for KCNB2 gene

Drugs & Compounds
for KCNB2 gene

Transcripts
for KCNB2 gene

Expression
for KCNB2 gene

Orthologs
for KCNB2 gene

Paralogs
for KCNB2 gene

Genomic Variants
for KCNB2 gene

Disorders / Diseases
for KCNB2 gene

Publications
for KCNB2 gene

Intellectual Property
for KCNB2 gene

Products
for KCNB2 gene