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Aliases & Descriptions for KCNB2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv2.2 3 | | delayed rectifier potassium channel protein 2 | | potassium channel Kv2.2 2 | | potassium voltage-gated channel subfamily B member 2 2 | potassium voltage-gated channel, Shab-related subfamily, member 2 2 |
|
| | Search outside databases for aliases for KCNB2 genePrevious GC identifers: GC08P072532 GC08P073420 GC08P073172 GC08P073499 |
Summaries for KCNB2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNB2: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient |
Genomic Location for KCNB2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNB2 gene 
Entrez Gene cytogenetic band: 8q13.2 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.2KCNB2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P073612:
(about GC identifiers)
Start:
|
73,612,180 bp from pter |
End:
|
74,013,138 bp from pter |
Size:
|
400,959 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008183.18
| Proteins for KCNB2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily B member 2 Size: 911 amino acids; 102563 Da
Subunit: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAB08433.1; Type=Frameshift; Positions=768;
Secondary accessions: Q7Z7D0 Q9BXD3Post-translational modifications:
Phosphorylated (Potential)1
REFSEQ proteins: NP_004761.2
ENSEMBL proteins: ENSP00000329426
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNB2: Assays for KCNB2: | Protein
Domains/ Families for KCNB2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q92953
ProtoNet protein and cluster: Q92953 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB005826 Kv2.2 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionDomain: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartmentsSimilarity: Belongs to the potassium channel family. B (Shab) subfamily | Gene Function for KCNB2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004770
Applied Biosystems Silencer® siRNAs for KCNB2
Sigma-Aldrich siRNA and siRNA Panels for KCNB2  Sigma-Aldrich shRNA Panels and shRNA for KCNB2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004770                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004770                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004770 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004770
UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradientGenatlas biochemistry entry for KCNB2:potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinal smooth muscles4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KCNB2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNB2 
5/45 Interacting proteins for KCNB2 (ENSP000003294263 Q929531) via UniProtKB, MINT, and/or STRING (see all 45
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNB2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNB2 available from Tocris Bioscience About this table
|
Transcripts for KCNB2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004770
Sigma-Aldrich siRNA and siRNA Panels for KCNB2  Sigma-Aldrich shRNA Panels and shRNA for KCNB2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004770 REFSEQ mRNAs for KCNB2 gene: NM_004770.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004770               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004770                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004770                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004770  Additional cDNA sequence: AF338730.1 AF450111.1 AK311263.1 U69962.1 1 DOTS entry: DT.92033542 5 AceView cDNA sequences:NM_004770 AF338730 AF450111 U69962 CK004440
highest scoring ESTs for KCNB2:U69962 AF338730 AF450111 CK004440 NM_004770 DA618105 AA017044 AA017045 AA332929 AA416661 Unigene Cluster for KCNB2: Potassium voltage-gated channel, Shab-related subfamily, member 2 Hs.661102 [show with all ESTs]Unigene Representative Sequence: AF338730
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNB2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | - |   | |   |
About this scheme
ECgene alternative splicing isoforms for KCNB2
1 Ensembl transcript including schematic representation: ENST00000329185
|
Expression for KCNB2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNB2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNB2
1 / 2 / 3 5 probe-sets matching KCNB2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACAGTTTAG
SOURCE GeneReport for Unigene cluster: Hs.661102
Expression variation in blood from EXPOLDB for KCNB2 |
Orthologs for KCNB2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNB2 gene from 5/10 species (see all 10
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNB21 |
-- |
potassium voltage-gated channel, Shab-related subfamily, more |
83.58(n) 90.62(a) |
403925 NM_001003247.1 NP_001003247.1 |
chimpanzee (Pan troglodytes) |
KCNB21 |
-- |
potassium voltage-gated channel, Shab-related subfamily, more |
99.63(n) 99.89(a) |
472792 XM_528164.2 XP_528164.2 |
cow (Bos taurus) |
KCNB21 |
-- |
potassium voltage-gated channel, Shab-related subfamily, more |
86.03(n) 92.52(a) |
535990 NM_001024563.1 NP_001019734.1 |
rat (Rattus norvegicus) |
Kcnb21 |
-- |
potassium voltage gated channel, Shab-related subfamily, more |
86.5(n) 92.78(a) |
117105 NM_054000.1 NP_446452.1 |
mouse (Mus musculus) |
Kcnb21, 5 |
1 (1.00 cM)5
|
potassium voltage gated channel, Shab-related subfamily, more1, 5 |
87.06(n)1 93.05(a)1 |
987411 XM_001473804.11 XP_001473854.11 AK0362395 AK0532775 (see all 8) |
About this table Species with no ortholog for KCNB2
ENSEMBL Gene Tree for KCNB2 | Paralogs for KCNB2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNB2 gene
- KCNB12 KCNV12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for KCNB2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNB2 (up to first 250kb)
|
Disorders & Mutations for KCNB2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607738
Human Genome Epidemiology Navigator: KCNB2 (2 documents)
|
Medical News for KCNB2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNB2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for KCNB2 gene (see all 13
): |
Search for KCNB2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNB2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNB2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNB2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNB2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNB2:

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 |  |  |
| | | | Tocris compounds for KCNB2 |
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Incremental update: 13 Oct 2009
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