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KCNB2 Gene

protein-coding GIFtS: 62
GCID: GC08P073499

Potassium Voltage-Gated Channel, Shab-Related Subfamily,...

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2¹ ²
Voltage-Gated Potassium Channel Subunit Kv2.2² ³
KV2.2² ⁵
Delayed Rectifier Potassium Channel Protein²
Potassium Channel Kv2.2²
Potassium Voltage-Gated Channel Subfamily B Member 2²

External Ids:	HGNC: 6232¹	Entrez Gene: 9312²	Ensembl: ENSG00000182674⁷	OMIM: 607738⁵	UniProtKB: Q92953³

Export aliases for KCNB2 gene to outside databases

Previous GC identifers: GC08P072532 GC08P073420 GC08P073172 GC08P073612 GC08P068946

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNB2 Gene:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart

rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and

cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified

in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium

channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is

expressed in gastrointestinal smooth muscle cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNB2 Gene:

KCNB2 (potassium voltage-gated channel, Shab-related subfamily, member 2) is a protein-coding gene. Diseases associated with KCNB2 include migraine, and crohn's disease. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close

in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their

electrochemical gradient

summary for KCNB2 Gene:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNB2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000008.11 NT_008183.20 NC_018919.2

Regulatory elements:

Regulatory transcription factor binding sites in the KCNB2 gene promoter:
AhR E2F-4 E2F-3a E2F-5 GATA-3 E2F-2 RORalpha2 Arnt E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNB2 promoter sequence

Search Chromatin IP Primers for KCNB2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.2 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.2

KCNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNB2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P073499: view genomic region (about GC identifiers)

Start:	73,449,626 bp from pter	End:	73,850,584 bp from pter
Size:	400,959 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily B member 2

Size: 911 amino acids; 102563 Da

Subunit: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity)

Sequence caution: Sequence=AAB08433.1; Type=Frameshift; Positions=768;

Secondary accessions: Q7Z7D0 Q9BXD3

Explore the universe of human proteins at neXtProt for KCNB2: NX_Q92953

Explore proteomics data for KCNB2 at MOPED

Post-translational modifications:

Phosphorylated (Potential)¹

Glycosylation² at Asn287

Modification sites at PhosphoSitePlus

See KCNB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004761.2

ENSEMBL proteins:

ENSP00000430846

Reactome Protein details: Q92953

KCNB2 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

KCN: Potassium channels

Kv: Voltage-gated ion channels / Potassium channels

IUPHAR Guide to PHARMACOLOGY protein family classification: K_v2.2

Voltage-gated potassium channels

Selected InterPro protein domains (see all 9):

IPR005821 Ion_trans_dom

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003973 K_chnl_volt-dep_Kv2

IPR005826 K_chnl_volt-dep_Kv2.2

Graphical View of Domain Structure for InterPro Entry Q92953

ProtoNet protein and cluster: Q92953

3 Blocks protein domains:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB005826 Kv2.2 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNB2_HUMAN, Q92953

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Domain: The tail may be important in modulation of channel activity and/or targeting of the channel to specific

subcellular compartments

Similarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily

KCNB2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: KCNB2_HUMAN, Q92953

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close

in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their

electrochemical gradient

Genatlas biochemistry entry for KCNB2:

potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinal

smooth muscles

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005249	voltage-gated potassium channel activity	--	--
GO:0005251	delayed rectifier potassium channel activity	TAS	9612272
GO:0005515	protein binding	--	--

KCNB2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnb2):

behavior/neurological

KCNB2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Kcnb2^tm1Lex for KCNB2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNB2

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

KCNB2_HUMAN, Q92953: Membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytosol	1
nucleus	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0016020	membrane	--	--

KCNB2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KCNB2 About

See pathways by source

SuperPath

Contained pathways About

Potassium Channels

	Potassium Channels	0.43			Potassium transporters outward current	0.41
	Voltage gated Potassium channels	0.43

Transmission across Chemical Synapses

Neuronal System

0.68

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNB2

Dopamine-DARPP32 Feedback onto cAMP Pathway

1 Reactome Pathway for KCNB2

Voltage gated Potassium channels

KCNB2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including KCNB2:

Neuronal Ion Channels in human mouse rat

Interactions:

GeneGlobe Interaction Network for KCNB2

2 Interacting proteins for KCNB2 (Q92953³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993³	I2D: score=1
KCNV1	Q6PIU1³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	--	--
GO:0006813	potassium ion transport	TAS	9612272
GO:0006940	regulation of smooth muscle contraction	TAS	9612272
GO:0007268	synaptic transmission	TAS	--
GO:0051260	protein homooligomerization	IEA	--

KCNB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for KCNB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
ICA 110381	KV7.2/7.3 activator; displays anticonvulsant properties	[325457-99-6]
XE 991 dihydrochloride	Potent, selective KV7 (KCNQ) channel blocker; blocks M-current	[122955-42-4]
JNJ 303	Potent and selective IKs blocker	[878489-28-2]
E-4031 dihydrochloride	KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)	[113559-13-0]
ShK-Dap22	Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro	[220384-25-8]

3 IUPHAR Ligands for KCNB2 (K_v2.2) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
quinine	Pore Blocker	None	4.9	9612272
4-aminopyridine	Pore Blocker	None	2.8	9612272
tetraethylammonium	Pore Blocker	None	2.6	9612272

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KCNB2 gene:

NM_004770.2

Unigene Cluster for KCNB2:

Potassium voltage-gated channel, Shab-related subfamily, member 2

Hs.661102 [show with all ESTs]

Unigene Representative Sequence: AF338730

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000523207(uc003xzb.3)

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		QuantiFast Probe-based Assays in human, mouse, rat KCNB2

Additional mRNA sequence:

AF338730.1 AF450111.1 AK311263.1 U69962.1

1 DOTS entry:

DT.92033542

5 AceView cDNA sequences:

AF338730 NM_004770 U69962 AF450111 CK004440

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNB2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5
SP1:
SP2:			-		-		-

ECgene alternative splicing isoforms for KCNB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACAGTTTAG

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KCNB2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KCNB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.661102

Pathway & Disease-focused RT² Profiler PCR Array including KCNB2:

Neuronal Ion Channels in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KCNB2 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kcnb2^{1 , 5}	potassium voltage gated channel, Shab-related subfamily, more^{1, 5}	87.06(n)¹ 93.05(a)¹		1 (4.50 cM)⁵ 98741¹ NM_001098528.2¹ NP_001091998.1¹ 15287259⁵
chicken (Gallus gallus)	Aves	KCNB2¹	potassium voltage-gated channel, Shab-related subfamily, more	77.92(n) 82.4(a)		431181 XM_003640825.2 XP_003640873.1
lizard (Anolis carolinensis)	Reptilia	KCNB2⁶	potassium voltage-gated channel, Shab-related subf...	80(a)	1 ↔ 1	4(33183548-33358294)
African clawed frog (Xenopus laevis)	Amphibia	kcnb2-B²	potassium voltage-gated channel, Shab-related subfamily, more	76.23(n)		U20342.1
zebrafish (Danio rerio)	Actinopterygii	LOC566883¹	potassium voltage-gated channel subfamily B member more	64.89(n) 69.77(a)		566883 XM_690167.4 XP_695259.4
fruit fly (Drosophila melanogaster)	Insecta	Shab³	potassium ion transport voltage-gated potassium more	68(a)		--

ENSEMBL Gene Tree for KCNB2 (if available)
TreeFam Gene Tree for KCNB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KCNB2 gene

KCNF1² KCNG3² KCNV1² KCNG2² KCNS2² KCNS3² KCNB1² KCNV2²

KCNG4² KCNG1² KCNS1²

Selected SIMAP similar genes for KCNB2 using alignment to 1 protein entry: KCNB2_HUMAN(see all similar genes):

KCNB1 KCNS3 KCNS2 KCNF1 KCNG1 KCNG2

KCNV1 KCNV2 KCND1 KCNG4 KCNS1 KCNA1

KCNG3 KCNA10 KCNA2 KCNA4 KCNC1 KCNA5

KCNB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_035774⁴		A colorectal cancer sample⁴	--	see VAR_035774	2	V I	mis⁴		0	--	--	--	--
rs200472384^1,2	C	untested¹	73849507(+)	`CCAGGA/G/TACAGA`	2	G	syn¹		0	--	--	--	--
rs73686066^1,2	C	--	73447646(+)	`ACAACA/CACCAA`	1	--	us2k¹		2		WA	120
rs112215765^1,2	F	--	73447650(+)	`CAACCA/CAAACA`	1	--	us2k¹		2		CSA WA	119
rs114639254^1,2	C,F	--	73447661(+)	`AAACAA/GAAACC`	1	--	us2k¹		1		WA	118
rs187652110^1,2		--	73447751(+)	`AGAGAA/GGATAG`	1	--	us2k¹		0	--	--	--	--
rs191361019^1,2		--	73447804(+)	`ACATGA/GAGTAT`	1	--	us2k¹		0	--	--	--	--
rs349336^1,2	C,A	--	73448053(-)	`gtgatA/Gttccc`	1	--	us2k¹		0	--	--	--	--
rs28407027^1,2	C	--	73448080(+)	`TGGGGC/TGGGGG`	1	--	us2k¹		1		NA	2
rs143588036^1,2		--	73448192(+)	`ACATGC/TACCCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNB2 (73449626 - 73699626 bp, first 250kb of KCNB2)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for KCNB2 (see all 35): About this table

Variant ID	Type	Subtype	PubMed ID
esv2673987	CNV	Deletion	23128226
esv2737160	CNV	Deletion	23290073
nsv436585	CNV	Deletion	17901297
esv4538	CNV	Deletion	18987735
esv1664475	CNV	Deletion	17803354
dgv186e180	CNV	Deletion	20482838
esv2497261	CNV	Deletion	19546169
esv2272208	CNV	Deletion	18987734
esv2737154	CNV	Deletion	23290073
esv269210	CNV	Insertion	20981092

Human Gene Mutation Database (HGMD): KCNB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607738 OMIM disorders: --

8 diseases for KCNB2:
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migraine crohn's disease breast and colorectal cancer multiple sclerosis

neuronitis pancreatitis colorectal cancer endotheliitis

KCNB2 for disorders About GeneDecksing

Genetic Association Database (GAD): KCNB2
Human Genome Epidemiology (HuGE) Navigator: KCNB2 (4 documents)

Export disorders for KCNB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNB2 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with KCNB2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PubMed id 9612272)^{1, 2, 3, 9} Schmalz F.... Horowitz B. (Am. J. Physiol. 1998)
A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)^{1, 4, 9} Nyholt D.R....Palotie A. (Hum. Mol. Genet. 2008)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)^{1, 4} Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)^{1, 4} Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)^{1, 4} Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (PLoS Genet. 2012)
Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle. (PubMed id 22422395)¹ Hristov K.L....Petkov G.V. (Am. J. Physiol., Cell Physiol. 2012)
Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PubMed id 19074135)¹ Mederos Y Schnitzler M.... Preisig-Muller R. (J. Biol. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9312	HGNC: 6232	AceView: KCNB2	Ensembl:ENSG00000182674	euGenes: HUgn9312
ECgene: KCNB2	H-InvDB: KCNB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KCNB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNB2 gene:
Search GeneIP for patents involving KCNB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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