Aliases for KCNB2 Gene
- Potassium Channel, Voltage Gated Shab Related Subfamily B, Member 2 2 3
- Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 2 3
- Voltage-Gated Potassium Channel Subunit Kv2.2 3 4
- KV2.2 3 6
- Potassium Voltage-Gated Channel Subfamily B Member 2 3
- Delayed Rectifier Potassium Channel Protein 3
- Potassium Channel Kv2.2 3
External Ids for KCNB2 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNB2 Gene
KCNB2 (Potassium Channel, Voltage Gated Shab Related Subfamily B, Member 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.
UniProtKB/Swiss-Prot for KCNB2 Gene
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.