Aliases for KCNB2 Gene
Aliases for KCNB2 Gene
- Potassium Voltage-Gated Channel Subfamily B Member 2 2 3 5
- Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 2 3
- Voltage-Gated Potassium Channel Subunit Kv2.2 3 4
- Potassium Channel, Voltage Gated Shab Related Subfamily B, Member 2 3
- Delayed Rectifier Potassium Channel Protein 3
- Potassium Channel Kv2.2 3
- KV2.2 3
External Ids for KCNB2 Gene
- HGNC: 6232
- Entrez Gene: 9312
- Ensembl: ENSG00000182674
- OMIM: 607738
- UniProtKB: Q92953
Previous GeneCards Identifiers for KCNB2 Gene
- GC08P073420
- GC08P073172
- GC08P073499
- GC08P073612
- GC08P068946
Summaries for KCNB2 Gene
-
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNB2 Gene
KCNB2 (Potassium Voltage-Gated Channel Subfamily B Member 2) is a Protein Coding gene. Diseases associated with KCNB2 include Brugada Syndrome. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.
UniProtKB/Swiss-Prot for KCNB2 Gene
-
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNB2 Gene
Genomics for KCNB2 Gene
Regulatory Elements for KCNB2 Gene
Enhancers for KCNB2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08F072607 | 0.5 | FANTOM5 | 7.7 | +70.2 | 70163 | 0.4 | GTF2E2 ZNF584 | KCNB2 GC08M072619 |
| GH08F072693 | 0.3 | FANTOM5 | 11.7 | +155.8 | 155835 | 0.1 | KCNB2 TERF1 LOC100419613 LOC101926908 | |
| GH08F072568 | 0.3 | FANTOM5 | 7.4 | +31.5 | 31460 | 0.2 | KCNB2 GC08M072619 | |
| GH08F072821 | 0.5 | FANTOM5 | 3.2 | +284.4 | 284402 | 0.3 | NFE2 MAFK NFE2L2 | KCNB2 PIR39255 GC08M072735 |
| GH08F072608 | 0.9 | FANTOM5 | 1.5 | +71.5 | 71548 | 0.3 | HDAC1 ARNT CHAMP1 ZEB1 ZNF766 GATA2 ZNF366 FOS CBFB ZEB2 | KCNB2 GC08M072619 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for KCNB2 Gene
- Chromosome:
- 8
- Start:
- 72,537,391 bp from pter
- End:
- 72,938,349 bp from pter
- Size:
- 400,959 bases
- Orientation:
- Plus strand
Genomic View for KCNB2 Gene
Genes around KCNB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.11 by Ensembl
- 8q21.11 by Entrez Gene
- 8q21.11 by HGNC
KCNB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNB2 Gene
Proteins for KCNB2 Gene
-
Protein details for KCNB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92953-KCNB2_HUMAN
- Recommended name:
- Potassium voltage-gated channel subfamily B member 2
- Protein Accession:
- Q92953
- Q7Z7D0
- Q9BXD3
Protein attributes for KCNB2 Gene
- Size:
- 911 amino acids
- Molecular mass:
- 102563 Da
- Quaternary structure:
-
- Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.
- SequenceCaution:
-
- Sequence=AAB08433.1; Type=Frameshift; Positions=768; Evidence={ECO:0000305};
Protein Expression for KCNB2 Gene
Post-translational modifications for KCNB2 Gene
- Phosphorylated.
- Glycosylation at Asn 287
- Modification sites at PhosphoSitePlus
Other Protein References for KCNB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KCNB2 (Potassium Channel Kv2.2)
-
Custom Antibody ServicesOriGene Antibodies for KCNB2
- Novus Biologicals Antibodies for KCNB2
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- antibodies-online Antibodies for KCNB2: See all 60
- Search GeneTex for Antibodies for KCNB2
-
St John's Laboratory Antibodies for KCNB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNB2
Protein Products
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- Search GeneTex for Proteins for KCNB2
Assay Products
- antibodies-online Kits for KCNB2: See all 6
No data available for DME Specific Peptides for KCNB2 Gene
Domains & Families for KCNB2 Gene
Gene Families for KCNB2 Gene
- HGNC:
- IUPHAR :
Protein Domains for KCNB2 Gene
Suggested Antigen Peptide Sequences for KCNB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92953UniProtKB/Swiss-Prot:
KCNB2_HUMAN :- The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
- Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
- Domain:
-
- The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
- Family:
-
- Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
Function for KCNB2 Gene
Molecular function for KCNB2 Gene
- GENATLAS Biochemistry:
- potassium voltage-gated channel,Drosophila Shab-related subfamily,member 2,expressed in (canine) gastrointestinal smooth muscles
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of about 20 msec. After that, inactivate very slowly. Their activation requires low threshold potentials of about -20 to -30 mV, with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -30 mV. Channels have an unitary conductance of about 14 pS. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and post-translational modifications. {ECO:0000250 UniProtKB:Q63099, ECO:0000305 PubMed:10414301};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP).
- UniProtKB/Swiss-Prot Function:
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005249 | voltage-gated potassium channel activity | IEA | -- |
| GO:0005251 | delayed rectifier potassium channel activity | ISS,TAS | -- |
| GO:0005267 | potassium channel activity | IEA | -- |
| GO:0046982 | protein heterodimerization activity | ISS | -- |
Phenotypes for KCNB2 Gene
- MGI mutant phenotypes for KCNB2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNB2:
Animal Models for KCNB2 Gene
- MGI Knock Outs for KCNB2:
-
- Kcnb2 tm1Lex
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNB2
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNB2 gene
- Search ViGene Biosciences for KCNB2
CRISPR Products
-
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miRNA for KCNB2 Gene
- miRTarBase miRNAs that target KCNB2
miRNA Products
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KCNB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for KCNB2
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNB2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNB2 Gene
Localization for KCNB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNB2 Gene
- Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. {ECO:0000250 UniProtKB:Q63099}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | ISS,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Potassium Channels | ||
| 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
| 3 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for KCNB2 Gene
3 Reactome pathways for KCNB2 Gene
1 Qiagen pathway for KCNB2 Gene
Interacting Proteins for KCNB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | ISS,TAS | -- |
| GO:0006940 | regulation of smooth muscle contraction | TAS | 9612272 |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNB2 Gene
Drugs & Compounds for KCNB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 4-Aminopyridine | Approved | Pharma | Pore Blocker, Target, antagonist | potassium channel-blocking agent, Non-selective KV channel blocker | 68 | |
| Quinine | Approved | Pharma | Pore Blocker, blocker | 45 | ||
| tetraethylammonium | Experimental | Pharma | Inhibitor | 1 | ||
| fampridine | Pharma | 0 | ||||
| GXTX-1E | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| HMR 1556 |
|
223749-46-0 |
|
|
(5) Tocris Compounds for KCNB2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 4-Aminopyridine | Non-selective KV channel blocker | 504-24-5 |
| E-4031 dihydrochloride | KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | 113559-13-0 |
| HMR 1556 | Potent and selective Iks channel blocker | 223749-46-0 |
| Linopirdine dihydrochloride | KV7 (KCNQ) channel blocker | 113168-57-3 |
| XE 991 dihydrochloride | Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents | 122955-13-9 |
Transcripts for KCNB2 Gene
mRNA/cDNA for KCNB2 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNB2
- GenScript: Design CRISPR guide RNA sequences for KCNB2
miRNA Products
- Search ViGene Biosciences for KCNB2
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KCNB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - | - | - |
Expression for KCNB2 Gene
mRNA differential expression in normal tissues according to GTEx for KCNB2 Gene
This gene is overexpressed in Brain - Cortex (x7.9), Brain - Frontal Cortex (BA9) (x7.6), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Hippocampus (x4.2).
This gene is overexpressed in Liver (64.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNB2 Gene:
KCNB2SOURCE GeneReport for Unigene cluster for KCNB2 Gene:
Hs.661102Primer Products
-
OriGene qPCR primer pairs for KCNB2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNB2 Gene
Orthologs for KCNB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNB2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNB2 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kcnb2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnb2 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNB2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNB2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNB2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNB2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KCNB2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnb2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | kcnb2-B 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | KCNB2 (2 of 2) 35 |
|
OneToMany | |
| kcnb2 35 |
|
OneToMany | |||
| LOC566883 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Shab 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | exp-2 36 |
|
|
|
| Y48A6B.6 36 |
|
|
|||
| C32C4.1 36 |
|
|
|||
| F44A2.2 36 |
|
|
|||
| Y55F3C.3 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14250 34 |
|
- Species where no ortholog for KCNB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KCNB2 Gene
Paralogs for KCNB2 Gene
(23) SIMAP similar genes for KCNB2 Gene using alignment to 1 proteins:
Variants for KCNB2 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs770305852 | A colorectal cancer sample | 72,936,703(+) | GCATC(A/G)TTTCT | nc-transcript-variant, reference, missense | |
| rs1002954 | -- | 72,828,945(-) | CACAG(A/G)TCAAC | intron-variant | |
| rs10081518 | -- | 72,885,537(+) | TCATC(A/G)TTTTC | intron-variant | |
| rs10087313 | -- | 72,839,919(+) | ttttt(C/T)ttttt | intron-variant | |
| rs10087370 | -- | 72,906,972(+) | TACTT(A/G)CTGAT | intron-variant |
Residual Variation Intolerance Score:
6.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.44;
43.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNB2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNB2 Gene
Disorders for KCNB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| brugada syndrome |
|
|
Search KCNB2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNB2
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNB2 Gene
Publications for KCNB2 Gene
- Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. (PMID: 9612272) Schmalz F. … Horowitz B. (Am. J. Physiol. 1998) 2 3 4 22 64
- A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 22 46 64
- Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 46 64
Products for KCNB2 Gene
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- antibodies-online Antibodies for KCNB2: See all 60
- antibodies-online Kits for KCNB2: See all 6
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for KCNB2
- Search GeneTex for Proteins for KCNB2
- ViGene Biosciences adenoviral particle packaged cDNA for KCNB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KCNB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KCNB2 gene
- Search ViGene Biosciences for KCNB2
- Santa Cruz Biotechnology (SCBT) Antibodies for KCNB2
- Search Santa Cruz Biotechnology (SCBT) for KCNB2 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for KCNB2 CRISPR
- Horizon Cell Lines for KCNB2
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNB2
- VectorBuilder custom plasmid, inducible vectors for KCNB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNB2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab