Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNB1 Gene

protein-coding   GIFtS: 63
GCID: GC20M047984

Potassium Voltage-Gated Channel, Shab-Related Subfamily,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 11 2     KV2.12
Delayed Rectifier Potassium Channel 12 3     Delayed Rectifier Potassium Channel Kv2.12
Voltage-Gated Potassium Channel Subunit Kv2.12 3     H-DRK1 K(+) Channel2
DRK12 3     Potassium Channel Protein DRK12
h-DRK12 3     Potassium Voltage-Gated Channel Subfamily B Member 12

External Ids:    HGNC: 62311   Entrez Gene: 37452   Ensembl: ENSG000001584457   OMIM: 6003975   UniProtKB: Q147213   

Export aliases for KCNB1 gene to outside databases

Previous GC identifers: GC20M047717 GC20M048626 GC20M048673 GC20M047421 GC20M044737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNB1 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its
activity is modulated by some other family members. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNB1 Gene: 
KCNB1 (potassium voltage-gated channel, Shab-related subfamily, member 1) is a protein-coding gene. Diseases associated with KCNB1 include arterial tortuosity syndrome, and sporotrichosis, and among its related super-pathways are Potassium Channels and Regulation of Insulin Secretion. GO annotations related to this gene include outward rectifier potassium channel activity and protein N-terminus binding. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close
in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their
electrochemical gradient

summary for KCNB1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNB1 gene promoter:
         Max1   NF-1   Spz1   NRSF form 1   LCR-F1   NRSF form 2   Ik-2   Chx10   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.2

KCNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNB1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M047984:  view genomic region     (about GC identifiers)

Start:
47,980,414 bp from pter      End:
48,099,184 bp from pter
Size:
118,771 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily B member 1  
Size: 858 amino acids; 95878 Da
Subunit: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA36156.1; Type=Erroneous initiation;
Secondary accessions: Q14193

Explore the universe of human proteins at neXtProt for KCNB1: NX_Q14721

Explore proteomics data for KCNB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines
    allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567,
    Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated
    dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through
    phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon.
    Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced
    during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14.
    Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively
    (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14721

  • KCNB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNB1 Protein Expression
    REFSEQ proteins: NP_004966.1  
    ENSEMBL proteins: 
     ENSP00000360806  
    Reactome Protein details: Q14721
    Human Recombinant Protein Products for KCNB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNB1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KCNB1
    GenScript Custom Purified and Recombinant Proteins Services for KCNB1
    Novus Biologicals KCNB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNB1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0030425dendrite IEA--
    GO:0032590dendrite membrane IEA--

    KCNB1 for ontologies           About GeneDecksing



    KCNB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNB1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCNB1
    GenScript Custom Superior Antibodies Services for KCNB1
    Novus Biologicals KCNB1 Antibodies
    Abcam antibodies for KCNB1
    Cloud-Clone Corp. Antibodies for KCNB1 
    ThermoFisher Antibodies for KCNB1
    LSBio Antibodies in human, mouse, rat for KCNB1 

    Assay Products for KCNB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNB1 
    Cloud-Clone Corp. CLIAs for KCNB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv2.1 
    Voltage-gated potassium channels

    5/9 InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003973 K_chnl_volt-dep_Kv2
     IPR027359 K_channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q14721

    ProtoNet protein and cluster: Q14721

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB004350 Kv2.1 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Domain: The tail may be important in modulation of channel activity and/or targeting of the channel to specific
    subcellular compartments
    Similarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily


    KCNB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNB1_HUMAN, Q14721
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close
    in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their
    electrochemical gradient

         Genatlas biochemistry entry for KCNB1:
    potassium voltage-gated channel,Drosophila Shab-related subfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding IPI10484328
    GO:0015271outward rectifier potassium channel activity IEA--
         
    KCNB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcnb1):
     endocrine/exocrine gland  homeostasis/metabolism 

    KCNB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNB1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNB1 (see all 16):
    hsa-miR-448 hsa-miR-548s hsa-miR-507 hsa-miR-652 hsa-miR-373* hsa-miR-298 hsa-miR-891b hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidKCNB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNB1
    Sirion Biotech Customized adenovirus for overexpression of KCNB1

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of KCNB1
    OriGene clones in human, mouse for KCNB1 (see all 7)
    OriGene ORF clones in mouse, rat for KCNB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNB1 (NM_004975)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB1
    Sirion Biotech Customized lentivirus for stable overexpression of KCNB1 
                         Customized lentivirus expression plasmids for stable overexpression of KCNB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNB1
    Search LifeMap BioReagents cell lines for KCNB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNB1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    Voltage gated Potassium channels0.43
    2Regulation of Insulin Secretion
    Regulation of Insulin Secretion0.74
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.55
    Integration of energy metabolism0.74
    3Transmission across Chemical Synapses
    Neuronal System0.67
    4Class C/3 (Metabotropic glutamate/pheromone receptors)
    Taste transduction0.45
    5Calcium Regulation in the Cardiac Cell
    Calcium Regulation in the Cardiac Cell0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNB1
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNB1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 BioSystems Pathway for KCNB1
        Calcium Regulation in the Cardiac Cell

    5/7        Reactome Pathways for KCNB1 (see all 7)
        Potassium Channels
    Regulation of Insulin Secretion by Glucagon-like Peptide-1
    Metabolism
    Regulation of Insulin Secretion
    Integration of energy metabolism


    1         Kegg Pathway  (Kegg details for KCNB1):
        Taste transduction


    KCNB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for KCNB1 (Q147213 ENSP000003608064) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNS3Q9BQ313, ENSP000003058244I2D: score=2 STRING: ENSP00000305824
    PTPREP234693, ENSP000002546674I2D: score=2 STRING: ENSP00000254667
    KCNG1Q9UIX43, ENSP000003606264I2D: score=1 STRING: ENSP00000360626
    KCNH1O952593, ENSP000002717514I2D: score=1 STRING: ENSP00000271751
    KCNV1Q6PIU13, ENSP000002974044I2D: score=1 STRING: ENSP00000297404
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006811ion transport ----
    GO:0006813potassium ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0044281small molecule metabolic process TAS--

    KCNB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    3 IUPHAR Ligands for KCNB1 (Kv2.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol
    Pore BlockerNone614722253
    linoleic acid
    Pore BlockerNone5.111546665
    tetraethylammonium
    InhibitorNone5.1--

    4 Novoseek inferred chemical compound relationships for KCNB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 60.6 15 18716211 (2), 11429406 (1), 10980613 (1), 12586336 (1) (see all 11)
    4-aminopyridine 51.7 1 12242265 (1)
    tetraethylammonium 49 1 12642579 (1)
    calcium 6.49 1 15353504 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNB1 gene: 
    NM_004975.2  

    Unigene Cluster for KCNB1:

    Potassium voltage-gated channel, Shab-related subfamily, member 1
    Hs.84244  [show with all ESTs]
    Unigene Representative Sequence: L02840
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371741(uc002xur.1 uc002xus.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNB1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNB1 (see all 16):
    hsa-miR-448 hsa-miR-548s hsa-miR-507 hsa-miR-652 hsa-miR-373* hsa-miR-298 hsa-miR-891b hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidKCNB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB1
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNB1 (see all 7)
    OriGene ORF clones in mouse, rat for KCNB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNB1 (NM_004975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB1
    Sirion Biotech Customized lentivirus for stable overexpression of KCNB1 
                         Customized lentivirus expression plasmids for stable overexpression of KCNB1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB1

    Additional mRNA sequence: 

    AF026005.1 BC127120.1 L02840.1 

    6 DOTS entries:

    DT.113446  DT.95362628  DT.97785231  DT.100742174  DT.101985667  DT.91776272 

    24/86 AceView cDNA sequences (see all 86):

    BM678090 BU730308 AI654891 BM716727 BM701250 AI627408 AF026005 AA069770 
    BQ189370 AA234922 BM931848 BM711704 F01932 BX954191 BQ186746 AA584187 
    F01875 BM702620 BX955525 AI458502 AA013066 NM_004975 BX491423 BM725609 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNB1 expression in normal human tissues (normalized intensities)      KCNB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCAGAGC
    KCNB1 Expression
    About this image


    KCNB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina

    See KCNB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNB1

    SOURCE GeneReport for Unigene cluster: Hs.84244
        SABiosciences Expression via Pathway-Focused PCR Array including KCNB1: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNB1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnb11 , 5 potassium voltage gated channel, Shab-related subfamily, more1, 5 86.62(n)1
    93.82(a)1
      2 (87.22 cM)5
    165001  NM_008420.41  NP_032446.21 
     1671033785 
    chicken
    (Gallus gallus)
    Aves KCNB11 potassium voltage-gated channel, Shab-related subfamily, more 75.44(n)
    84.53(a)
      428146  XM_425704.2  XP_425704.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia kcnb1-A2 potassium voltage-gated channel, Shab-related subfamily, more 74.94(n)    U20343.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnb11 potassium voltage-gated channel, Shab-related subfamily, more 67.9(n)
    71.22(a)
      555284  XM_677756.3  XP_682848.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Shab3 potassium ion transport voltage-gated
    potassium more
    69(a)     --


    ENSEMBL Gene Tree for KCNB1 (if available)
    TreeFam Gene Tree for KCNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNB1 gene
    KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS22  KCNS32  KCNV22  
    KCNG42  KCNG12  KCNS12  
    18/25 SIMAP similar genes for KCNB1 using alignment to 2 protein entries:     KCNB1_HUMAN (see all proteins) (see all similar genes):
    KCNV1    KCNG1    KCNB2    KCNF1    KCNS2    KCNS3
    KCNG2    KCNS1    KCNG4    KCNV2    KCNA1    KCNA3
    KCND2    KCNG3    KCNA10    KCNA4    KCNA2    KCNC2

    KCNB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2343 SNPs in KCNB1 are shown (see all 2343)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898413961,2
    --44849628(+) CAGATA/CGGAAC 1 -- us2k10--------
    rs15022451,2
    C,F,A,H--44849716(-) GATGTA/GTTCAT 1 -- us2k124Minor allele frequency- G:0.38NS EA NA CSA WA 2352
    rs1816169691,2
    --44849744(+) GCAGGG/TGGTGA 1 -- us2k10--------
    rs2008528041,2
    C--44849753(-) TAGCGG/TTTATC 1 -- us2k10--------
    rs1506518941,2
    --47988203(+) TGTATA/GCTTGA 1 -- ds50010--------
    rs1870231771,2
    --47988204(+) GTATAC/TTTGAC 1 -- ds50010--------
    rs1919230431,2
    --47988320(+) GACAGC/TAATAC 1 -- ds50010--------
    rs622076391,2
    F--47988458(+) AACCTA/GTTTTT 1 -- ds50012Minor allele frequency- G:0.05NA 122
    rs33311,2
    C,F,H--47988601(+) TTCAAT/CGCGTG 1 -- ut3110Minor allele frequency- C:0.08MN NA NS EA CSA 646
    rs1180345121,2
    C,F--47988624(+) TTTCAT/CTTTTG 1 -- ut311Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for KCNB1 (47980414 - 48099184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661866CNV Deletion23128226
    nsv509775CNV Insertion20534489
    nsv912914CNV Loss21882294
    nsv459001CNV Loss19166990
    nsv527882CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600397    OMIM disorders: --

    11 diseases for KCNB1:    About MalaCards
    arterial tortuosity syndrome    sporotrichosis    cutis laxa    brain ischemia
    patent ductus arteriosus    ischemia    hepatitis c    hypoxia
    neuronitis    hepatitis    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for KCNB1:
    Sporotrichosis     Blastomycosis

    KCNB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNB1
    Human Genome Epidemiology (HuGE) Navigator: KCNB1 (3 documents)

    Export disorders for KCNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNB1 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with KCNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. (PubMed id 19265782)1, 4 BarbaliA8 M....Rudan P. (2009)
    3. Genome-wide association study identifies single-nucle otide polymorphism in KCNB1 associated with left ventricular mass in humans: th e HyperGEN Study. (PubMed id 19454037)1, 4 Arnett D.K....Broeckel U. (2009)
    4. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2. (PubMed id 7774931)1, 3 Melis R....Leppert M. (1995)
    7. Cloning and characterization of a human delayed rectifier potassium channel gene. (PubMed id 8081723)1, 2 Albrecht B.... Pongs O. (1993)
    8. Identification of a Ser857-Asn857 substitution in DRK1 (KCNB1), population frequencies and lack of association to the low voltage alpha EEG trait. (PubMed id 8698327)4, 9 Mazzanti C.M....Goldman D. (1996)
    9. Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. (PubMed id 12403834)1, 9 MacDonald P.E....Gaisano H.Y. (2002)
    10. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (PubMed id 15353504)1, 9 Thebaud B....Archer S.L. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3745 HGNC: 6231 AceView: KCNB1 Ensembl:ENSG00000158445 euGenes: HUgn3745
    ECgene: KCNB1 Kegg: 3745 H-InvDB: KCNB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNB1 gene:
    Search GeneIP for patents involving KCNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Clones for the Expression of KCNB1
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNB1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCNB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KCNB1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNB1   OriGene Custom Protein Services for KCNB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNB1
     QIAGEN SeqTarget long-range PCR primers for resequencing KCNB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNB1
     GenScript Custom Purified and Recombinant Proteins Services for KCNB1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNB1
     GenScript Custom Assay Services for KCNB1 GenScript Custom Superior Antibodies Services for KCNB1
     GenScript Custom overexpressing Cell Line Services for KCNB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNB1 promoter
     Search Chromatin IP Primers for KCNB1
     RT2 qPCR Primer Assay in human, mouse, rat KCNB1
     GNC Network for KCNB1
     SABiosciences PCR Arrays including human, mouse, rat KCNB1
     Tocris compounds for KCNB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNB1 antibodies
     KCNB1 lysates
     Antibodies for KCNB1
     See all of Abcam's Antibodies, Kits and Proteins for KCNB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KCNB1
     Antibodies for KCNB1
     ELISAs for KCNB1
     CLIAs for KCNB1
     Search LifeMap BioReagents cell lines for KCNB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNB1
     SwitchGear 3'UTR luciferase reporter plasmids for KCNB1
     SwitchGear Promoter luciferase reporter plasmids for KCNB1
     ThermoFisher Antibodies for KCNB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNB1
    Customized:
     lentivirus for stable overexpression of KCNB1
     lentivirus expression plasmids for stable overexpression of KCNB1
     adenovirus for overexpression of KCNB1
     LSBio Antibodies in human, mouse, rat for KCNB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4