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KCNB1 Gene

protein-coding GIFtS: 65

GC20M047421

potassium voltage-gated channel, Shab-related subfamily, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DRK1 ^²
KV2.1 ^²
Kv2.1 ^¹
OTTHUMP00000031697 ^²
h-DRK1 ^², ³

Descriptions
Voltage-gated potassium channel subunit Kv2.1 ^³
delayed rectifier potassium channel Kv2.1 ^²
h-DRK1 K(+) channel ^²
potassium channel protein DRK1 ^²
potassium voltage-gated channel subfamily B member 1 ^²
potassium voltage-gated channel, Shab-related subfamily, member 1 ^²
voltage-gated potassium channel ^²

External Ids
HGNC: 6231¹
Entrez Gene: 3745²
UniProtKB: Q14721³
Ensembl: ENSG00000158445⁷

Search outside databases for aliases for KCNB1 gene

Previous GC identifers: GC20M047717 GC20M048626 GC20M048673

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNB1:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four

sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in

Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the

potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier

potassium channel and its activity is modulated by some other family members. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Channels open or close in response to the voltage difference across the membrane, letting

potassium ions pass in accordance with their electrochemical gradient

Gene Wiki entry for KCNB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNB1 gene

Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.2

KCNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M047421: (about GC identifiers)

Start:	47,421,912 bp from pter
End:	47,532,588 bp from pter
Size:	110,677 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily B member 1

Size: 858 amino acids; 95878 Da

Subunit: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q14193

Post-translational modifications:

Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a

subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation

on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are

all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are

significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation

activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels

on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during

postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by

P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and

85% respectively (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004966.1

ENSEMBL proteins:

ENSP00000360806

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNB1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNB1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNB1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNB1
	Sigma-Aldrich Antibodies for KCNB1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNB1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNB1)
	Search Novus for antibodies for KCNB1

Assays for KCNB1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14721

ProtoNet protein and cluster: Q14721

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB004350 Kv2.1 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Domain: The tail may be important in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Similarity: Belongs to the potassium channel family. B (Shab) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004975

Applied Biosystems Silencer® siRNAs for KCNB1

Sigma-Aldrich siRNA and siRNA Panels for KCNB1

Sigma-Aldrich shRNA Panels and shRNA for KCNB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNB1
		Millipore Clones for the Expression of KCNB1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004975
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004975
untagged cDNA clone in CMV expression vector: NM_004975

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004975

UniProtKB/Swiss-Prot: KCNB1_HUMAN, Q14721

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Channels open or close in response to the voltage difference across the membrane, letting

potassium ions pass in accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNB1:

potassium voltage-gated channel,Drosophila Shab-related subfamily

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kcnb1):

digestive/alimentary

endocrine/exocrine gland

homeostasis/metabolism

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0005515	protein binding	IPI	10484328 11852086
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNB1

5/23 Interacting proteins for KCNB1 (ENSP00000360806³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNAP25	ENSP00000254976³	STRING (score=.98)
STX1A	ENSP00000222812³	STRING (score=.98)
PTPRE	ENSP00000254667³	STRING (score=.919)
GYG1	ENSP00000340736³	STRING (score=.915)
NFATC3	ENSP00000300659³	STRING (score=.91)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNB1

Sigma-Aldrich Small Molecules for KCNB1:

Inhibitor

Compounds for KCNB1 available from Tocris Bioscience

Compound	Action	CAS number
Chromanol 293B	IKs blocker. Also blocks ICFTR	[163163-23-3]
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
(-)-[3R,4S]-Chromanol 293B	IKs blocker. Enantiomer of (Cat. No. 1412)	[163163-24-4]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

2 Novoseek chemical compound relationships for KCNB1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	61.55	15	18716211 (2), 11429406 (1), 10980613 (1), 12586336 (1) (see all 11)
calcium	7.68	1	15353504 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004975

Sigma-Aldrich siRNA and siRNA Panels for KCNB1

Sigma-Aldrich shRNA Panels and shRNA for KCNB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004975

REFSEQ mRNAs for KCNB1 gene:

NM_004975.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004975

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004975
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004975
                                 untagged cDNA clone in CMV expression vector: NM_004975

Additional cDNA sequence:

AF026005.1 BC110572.1 BC110573.1 BC127120.1 L02840.1

2 DOTS entries:

DT.113446 DT.95362628

24/86 AceView cDNA sequences (see all 86 ):

BM675921 BU729580 BM702620 BM716727 BM701250 AI627408 BX954191 AA234922

BM725609 BX491423 AA722102 BQ189370 AA584187 NM_004975 BM711704 AI654891

BM703328 AA069770 F01932 F01875 BM678090 BU730308 AA013066 AF026005

highest scoring ESTs for KCNB1:

L02840 AA166676 AF026005 BF919072 BF919145 BX955525 AA063012 AA063031 AA069746 AA069770

Unigene Cluster for KCNB1:

Potassium voltage-gated channel, Shab-related subfamily, member 1

Hs.84244 [show with all ESTs]

Unigene Representative Sequence: L02840

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000371741

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNB1

¹ / ² / ³

3 probe-sets matching KCNB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40693_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L02840	1.00	1.00	1.00	1
211006_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L02840	1.00	1.00	1.00	1
211006_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACTCAGAGC

SOURCE GeneReport for Unigene cluster: Hs.84244
Expression variation in blood from EXPOLDB for KCNB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNB1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNB1¹	--	potassium voltage-gated channel, Shab-related subfamily, more	93.32(n) 97.44(a)	485918 XM_543042.2 XP_543042.2
chimpanzee (Pan troglodytes)	KCNB1¹	--	potassium voltage-gated channel, Shab-related subfamily, more	99.73(n) 100(a)	469965 XM_525349.2 XP_525349.2
cow (Bos taurus)	KCNB1¹	--	potassium voltage-gated channel, Shab-related subfamily, more	91.96(n) 96.39(a)	539528 XM_587915.3 XP_587915.3
rat (Rattus norvegicus)	Kcnb1¹	--	potassium voltage gated channel, Shab-related subfamily, more	86.91(n) 94.14(a)	25736 NM_013186.1 NP_037318.1
mouse (Mus musculus)	Kcnb1^{1, 5}	2 (97.00 cM)⁵	potassium voltage gated channel, Shab-related subfamily, more^{1, 5}	86.62(n)¹ 93.82(a)¹	16500¹ NM_008420.3¹ NP_032446.2¹ AL591711⁵ AL591854⁵ (see all 15)

About this table Species with no ortholog for KCNB1

ENSEMBL Gene Tree for KCNB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNB1 gene

KCNB2² KCNV1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/734 NCBI SNPs in KCNB1 are shown (see all 734 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 274)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1051295^1,2	A,C,F,H,O	47422312(-)	`GTACCC/TGAGAT`	1	--	ut3¹		16	EA NA EU WA	2652
	rs3331^1,2	C,F,H	47422008(+)	`TTCAAT/CGCGTG`	1	--	ut3¹		6	MN NA EU EA	520
	rs34467662^1,2	C,F	47423031(-)	`AAGGCC/TCCAGT`	1	P/S	mis¹		5	NA EU EA WA	494
	rs2229006^1,2	C,F	47423657(-)	`CAAGAA/C/GTGGGG`	2	T/N T/S	mis¹ ese³		2	MN NA	92
--	rs9798^1,2	A,F	47422303(-)	`ATTTTA/TTTTTG`	1	--	ut3¹		1	MN	184
--	rs34280195^1,2	C	47422934(-)	`TCAGAG/ACATCT`	1	N/S	mis¹		1	NA	70
	rs2664551^1,2	H	47422132(+)	`ATCTTT/GTGAGT`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs490196^1,2	F	47533196(+)	`GAGGTC/TACAAC`	1	--	ng3¹		1	MN	184
	rs520282^1,2	C,F,H	47532227(-)	`ACGCAC/TGACTC`	1	H/H	syn¹ ese³		8	NA EU EA WA	462
	rs6090970^1,2	F,H	47423356(+)	`ACAGCC/TTTGTC`	1	K/K	syn¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for KCNB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600397

Genetic Association Database: KCNB1
Human Genome Epidemiology Navigator: KCNB1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/55 PubMed articles for KCNB1 gene (see all 55 ):

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2. (PubMed id 7774931)^{2, 3} Melis R....Leppert M. (1995)
Cloning and characterization of a human delayed rectifier potassium channel gene. (PubMed id 8081723)^{3, 4} Albrecht B.... Pongs O. (1993)
Identification of a Ser857-Asn857 substitution in DRK1 (KCNB1), population frequencies and lack of association to the low voltage alpha EEG trait. (PubMed id 8698327)^{1, 6} Mazzanti C.M....Goldman D. (1996)
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. (PubMed id 12403834)^{1, 3} MacDonald P.E....Gaisano H.Y. (2002)
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (PubMed id 15353504)^{1, 3} Thebaud B....Archer S.L. (2004)
Heterologous expression of the human potassium channel Kv2.1 in clonal mammalian cells by direct cytoplasmic microinjection of cRNA. (PubMed id 1283219)^{1, 4} Ikeda S.R....Lewis D.L. (1992)
Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135)³ Mederos Y Schnitzler M.... Preisig-Muller R. (2009)
A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. (PubMed id 19265782)³ BarbaliA8 M....Rudan P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3745	HGNC: 6231	AceView: KCNB1	Ensembl:ENSG00000158445	euGenes: HUgn3745
ECgene: KCNB1	H-InvDB: KCNB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNB1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNB1		Antibodies for KCNB1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNB1		Small molecules for KCNB1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for KCNB1

Tocris compounds for KCNB1

	Drugs for KCNB1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KCNB1

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KCNB1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for KCNB1

Summaries
for KCNB1

Genomic Location
for KCNB1

Proteins
for KCNB1

Protein Domains/
Families
for KCNB1

Gene Function
for KCNB1

Pathways & Interactions
for KCNB1

Drugs & Compounds
for KCNB1

Transcripts
for KCNB1

Expression
for KCNB1

Orthologs
for KCNB1

Paralogs
for KCNB1

SNPs/Variants
for KCNB1

Disorders & Mutations
for KCNB1

Medical News
for KCNB1

Publications
for KCNB1

Search for KCNB1

Genome Databases showing KCNB1

Other Databases showing KCNB1

Specialized Databases showing KCNB1

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNB1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor KCNB1

Summariesfor KCNB1

Genomic Locationfor KCNB1

Proteinsfor KCNB1

Protein Domains/Familiesfor KCNB1

Gene Functionfor KCNB1

Pathways & Interactionsfor KCNB1

Drugs & Compoundsfor KCNB1

Transcriptsfor KCNB1

Expression for KCNB1

Orthologsfor KCNB1

Paralogsfor KCNB1

SNPs/Variantsfor KCNB1

Disorders & Mutationsfor KCNB1

Medical Newsfor KCNB1

Publicationsfor KCNB1

Search for KCNB1

Genome Databases showing KCNB1

Other Databases showing KCNB1

Specialized Databases showing KCNB1

Licensable Technologiesfor KCNB1

Servicesfor KCNB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNB1

Summaries
for KCNB1

Genomic Location
for KCNB1

Proteins
for KCNB1

Protein Domains/
Families
for KCNB1

Gene Function
for KCNB1

Pathways & Interactions
for KCNB1

Drugs & Compounds
for KCNB1

Transcripts
for KCNB1

Expression
for KCNB1

Orthologs
for KCNB1

Paralogs
for KCNB1

SNPs/Variants
for KCNB1

Disorders & Mutations
for KCNB1

Medical News
for KCNB1

Publications
for KCNB1

Licensable Technologies
for KCNB1

Services
for KCNB1