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Aliases & Descriptions for KCNAB3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AKR6A9 1, 2 | | KCNA3.1B 2 | | KCNA3B 1, 2, 3, 5 | | KV-BETA-3 2 | | Kv-beta-3 3 | | MGC116886 2 |
| | | Descriptions |
|---|
| K(+) channel subunit beta-3 3 | | K+ channel beta-3 subunit 2 | | potassium channel, voltage-dependent, beta-3 subunit 2 | potassium voltage-gated channel, shaker-related subfamily, beta member 3 2 |
|
| | Search outside databases for aliases for KCNAB3 genePrevious GC identifers: GC17M008292 GC17M008697 GC17M007768 GC17M008026 |
Summaries for KCNAB3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNAB3: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member and the KCNA5 gene product assemble into a heteromultimeric A-type channel that inactivates completely and is significantly faster than other A-type Kv channels. [provided by RefSeq] UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 |
Genomic Location for KCNAB3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNAB3 gene 
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1KCNAB3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M007766:
(about GC identifiers)
Start:
|
7,766,752 bp from pter |
End:
|
7,773,478 bp from pter |
Size:
|
6,727 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010718.15
| Proteins for KCNAB3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448 (See
protein sequence)Recommended Name: Voltage-gated potassium channel subunit beta-3 Size: 404 amino acids; 43670 Da
Subunit: Forms heteromultimeric complex with alpha subunits
Subcellular location: Cytoplasm (Potential)
Secondary accessions: Q4VAW0REFSEQ proteins: NP_004723.2
ENSEMBL proteins: ENSP00000302719
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for KCNAB3: Assays for KCNAB3: | Protein
Domains/ Families for KCNAB3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43448
ProtoNet protein and cluster: O43448 2 Blocks protein families: IPB001395 Aldo/keto reductase IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature
UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)Similarity: Belongs to the shaker potassium channel beta subunit family | Gene Function for KCNAB3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004732
Applied Biosystems Silencer® siRNAs for KCNAB3
Sigma-Aldrich siRNA and siRNA Panels for KCNAB3  Sigma-Aldrich shRNA Panels and shRNA for KCNAB3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004732                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004732                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004732 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004732
UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5Genatlas biochemistry entry for KCNAB3:potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in the brain and,predominantly in the cerebellum,auxiliary beta 3 cytoplasmic peptide,co assembly in the endoplasmic reticulum with the channel forming alpha subunits5 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0015459 | potassium channel regulator activity |
TAS | 9857044 | | GO:0016491 | oxidoreductase activity |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNAB3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNAB3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNAB3 available from Tocris Bioscience About this table
|
Transcripts for KCNAB3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004732
Sigma-Aldrich siRNA and siRNA Panels for KCNAB3  Sigma-Aldrich shRNA Panels and shRNA for KCNAB3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004732 REFSEQ mRNAs for KCNAB3 gene: NM_004732.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004732               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004732                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004732                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004732  Additional cDNA sequence: AF016411.1 AK309378.1 AK309807.1 BC096232.1 BC096234.3 BC099634.1 4 DOTS entries: DT.65287315 DT.40255353 DT.40255364 DT.99933479 24/384 AceView cDNA sequences (see all 384
):AA133344 CD672530 AI192586 BM663873 BU944766 BM708341 BM708261 BQ776624 H02021 CR612174 BQ277958 CA841706 BU171673 BM091038 BM790667 BU729286 H92563 BM811338 BM671333 CA411962 BM762006 BI767775 BQ186900 AA455789
highest scoring ESTs for KCNAB3:AF016411 AI090408 DA079107 DA087088 DA493633 DA800702 DB172236 AA716741 AI092060 AI208219 Unigene Cluster for KCNAB3: Potassium voltage-gated channel, shaker-related subfamily, beta member 3 Hs.435074 [show with all ESTs]Unigene Representative Sequence: NM_004732
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB3
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | |
| SP1: | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KCNAB3
1 Ensembl transcript including schematic representation: ENST00000303790
|
Expression for KCNAB3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNAB3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNAB3
1 / 2 / 3 2 probe-sets matching KCNAB3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCTACTCGC
SOURCE GeneReport for Unigene cluster: Hs.435074 UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448Tissue specificity: Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle |
Orthologs for KCNAB3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNAB3 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNAB31 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
91.91(n) 96.53(a) |
489483 XM_546601.2 XP_546601.2 |
chimpanzee (Pan troglodytes) |
KCNAB31 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
99.59(n) 99.75(a) |
455208 XM_001172327.1 XP_001172327.1 |
rat (Rattus norvegicus) |
Kcnab31 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
89.44(n) 92.33(a) |
58981 NM_031652.1 NP_113840.1 |
mouse (Mus musculus) |
Kcnab31, 5 |
115
|
potassium voltage-gated channel, shaker-related subfamily, more1, 5 |
88.37(n)1 92.82(a)1 |
164991 NM_010599.31 NP_034729.21 AI8431925 AK0297505 (see all 15) |
fruit fly (Drosophila melanogaster) |
Hk3 |
1 9B5 |
potassium ion transport voltage-gated potassium more |
45(a) |
-- |
About this table Species with no ortholog for KCNAB3
ENSEMBL Gene Tree for KCNAB3 | Paralogs for KCNAB3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNAB3 gene
- KCNAB12 KCNAB22
|
SNPs/Variants for KCNAB3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNAB3 (up to first 250kb)
|
Disorders & Mutations for KCNAB3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604111
|
Medical News for KCNAB3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNAB3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for KCNAB3 gene:- Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. (PubMed id 9857044)1, 2, 3, 4 Leicher T.... Pongs O. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)3 Bonaldo M.F....Soares M.B. (1996)
- Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)3 Mccormack K.... Stuehmer W. (1995)
- Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle. (PubMed id 7631872)1 Castellino R.C....Rasmusson R.L. (1995)
- Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle. (PubMed id 17040965)1 McGahon M.K....Curtis T.M. (2007)
|
Search for KCNAB3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNAB3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNAB3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNAB3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNAB3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNAB3:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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