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Aliases for KCNAB3 Gene

Aliases for KCNAB3 Gene

  • Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 3 2 3
  • Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 3 2 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 3 2 3
  • K(+) Channel Subunit Beta-3 3 4
  • KV-BETA-3 3 4
  • KCNA3B 3 4
  • Potassium Channel, Voltage-Dependent, Beta-3 Subunit 3
  • KCNA3.1B 3
  • AKR6A9 3

External Ids for KCNAB3 Gene

Previous GeneCards Identifiers for KCNAB3 Gene

  • GC17M008292
  • GC17M008697
  • GC17M007768
  • GC17M008026
  • GC17M007766
  • GC17M007825
  • GC17M007720

Summaries for KCNAB3 Gene

Entrez Gene Summary for KCNAB3 Gene

  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]

GeneCards Summary for KCNAB3 Gene

KCNAB3 (Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 3) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNAB1.

UniProtKB/Swiss-Prot for KCNAB3 Gene

  • Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.

Tocris Summary for KCNAB3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNAB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNAB3 Gene

Genomics for KCNAB3 Gene

Regulatory Elements for KCNAB3 Gene

Enhancers for KCNAB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNAB3 on UCSC Golden Path with GeneCards custom track

Promoters for KCNAB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNAB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNAB3 Gene

Chromosome:
17
Start:
7,921,859 bp from pter
End:
7,929,803 bp from pter
Size:
7,945 bases
Orientation:
Minus strand

Genomic View for KCNAB3 Gene

Genes around KCNAB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNAB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNAB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNAB3 Gene

Proteins for KCNAB3 Gene

  • Protein details for KCNAB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43448-KCAB3_HUMAN
    Recommended name:
    Voltage-gated potassium channel subunit beta-3
    Protein Accession:
    O43448
    Secondary Accessions:
    • Q4VAW0

    Protein attributes for KCNAB3 Gene

    Size:
    404 amino acids
    Molecular mass:
    43670 Da
    Quaternary structure:
    • Forms heteromultimeric complex with alpha subunits.

neXtProt entry for KCNAB3 Gene

Proteomics data for KCNAB3 Gene at MOPED

Post-translational modifications for KCNAB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNAB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNAB3 Gene

Domains & Families for KCNAB3 Gene

Suggested Antigen Peptide Sequences for KCNAB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43448

UniProtKB/Swiss-Prot:

KCAB3_HUMAN :
  • Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.
  • Belongs to the shaker potassium channel beta subunit family.
Domain:
  • Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.
Family:
  • Belongs to the shaker potassium channel beta subunit family.
genes like me logo Genes that share domains with KCNAB3: view

Function for KCNAB3 Gene

Molecular function for KCNAB3 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in the brain and,predominantly in the cerebellum,auxiliary beta 3 cytoplasmic peptide,co assembly in the endoplasmic reticulum with the channel forming alpha subunits
UniProtKB/Swiss-Prot Function:
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.
genes like me logo Genes that share phenotypes with KCNAB3: view

Animal Model Products

miRNA for KCNAB3 Gene

miRTarBase miRNAs that target KCNAB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNAB3 Gene

Localization for KCNAB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNAB3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNAB3 Gene COMPARTMENTS Subcellular localization image for KCNAB3 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KCNAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNAB3: view

Pathways & Interactions for KCNAB3 Gene

genes like me logo Genes that share pathways with KCNAB3: view

Pathways by source for KCNAB3 Gene

1 BioSystems pathway for KCNAB3 Gene
1 Qiagen pathway for KCNAB3 Gene

Interacting Proteins for KCNAB3 Gene

Gene Ontology (GO) - Biological Process for KCNAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA,TAS 9857044
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with KCNAB3: view

No data available for SIGNOR curated interactions for KCNAB3 Gene

Drugs & Compounds for KCNAB3 Gene

(1) Drugs for KCNAB3 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNAB3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNAB3 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNAB3: view

Transcripts for KCNAB3 Gene

Unigene Clusters for KCNAB3 Gene

Potassium voltage-gated channel, shaker-related subfamily, beta member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for KCNAB3 Gene

GeneLoc Exon Structure for
KCNAB3
ECgene alternative splicing isoforms for
KCNAB3

Expression for KCNAB3 Gene

mRNA expression in normal human tissues for KCNAB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNAB3 Gene

This gene is overexpressed in Brain - Cerebellum (x8.6), Brain - Cerebellar Hemisphere (x8.0), and Uterus (x4.1).

Protein differential expression in normal tissues from HIPED for KCNAB3 Gene

This gene is overexpressed in Brain (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNAB3 Gene



SOURCE GeneReport for Unigene cluster for KCNAB3 Gene Hs.435074

mRNA Expression by UniProt/SwissProt for KCNAB3 Gene

O43448-KCAB3_HUMAN
Tissue specificity: Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with KCNAB3: view

Protein tissue co-expression partners for KCNAB3 Gene

- Elite partner

Primer Products

Orthologs for KCNAB3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KCNAB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNAB3 35
  • 92.9 (n)
  • 96.53 (a)
KCNAB3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNAB3 35
  • 91.91 (n)
  • 96.53 (a)
KCNAB3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnab3 35
  • 88.45 (n)
  • 93.07 (a)
Kcnab3 16
Kcnab3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNAB3 35
  • 99.5 (n)
  • 99.5 (a)
KCNAB3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnab3 35
  • 89.44 (n)
  • 92.33 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNAB3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNAB3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNAB3 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnab3 35
  • 67.25 (n)
  • 75.57 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334158 35
  • 66 (n)
  • 71.22 (a)
KCNAB3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hk 37
  • 45 (a)
Hk 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KCNAB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNAB3 Gene

ENSEMBL:
Gene Tree for KCNAB3 (if available)
TreeFam:
Gene Tree for KCNAB3 (if available)

Paralogs for KCNAB3 Gene

Paralogs for KCNAB3 Gene

(2) SIMAP similar genes for KCNAB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNAB3: view

Variants for KCNAB3 Gene

Sequence variations from dbSNP and Humsavar for KCNAB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4396585 -- 7,925,552(+) AAAAA(A/G)AATTC intron-variant
rs4444395 -- 7,924,957(+) CCCAG(A/G)CTGTT intron-variant
rs8070212 -- 7,926,610(+) CACTT(A/G)TGACA intron-variant
rs9747329 -- 7,928,419(+) TGACT(G/T)GTGAA intron-variant
rs9891006 -- 7,922,256(+) TTAGG(G/T)TTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNAB3 Gene

Variant ID Type Subtype PubMed ID
nsv907654 CNV Loss 21882294
nsv457660 CNV Loss 19166990
esv2670156 CNV Deletion 23128226

Variation tolerance for KCNAB3 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCNAB3 Gene

Disorders for KCNAB3 Gene

Relevant External Links for KCNAB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNAB3

No disorders were found for KCNAB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNAB3 Gene

Publications for KCNAB3 Gene

  1. Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. (PMID: 9857044) Leicher T. … Pongs O. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3
  5. Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle. (PMID: 17040965) McGahon M.K. … Curtis T.M. (Am. J. Physiol. Heart Circ. Physiol. 2007) 23

Products for KCNAB3 Gene

Sources for KCNAB3 Gene

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