Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNAB3 Gene

protein-coding GIFtS: 53
GCID: GC17M007825

potassium voltage-gated channel, shaker-related subfamily,...

Explore 5 diseases affiliated with
KCNAB3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 3¹ ²		KV-BETA-3²
KCNA3B¹ ² ³ ⁵		Potassium Channel, Voltage-Dependent, Beta-3 Subunit²
AKR6A9¹ ²		Voltage-Gated Potassium Channel Subunit Beta-3²
K(+) Channel Subunit Beta-3² ³		Kv-Beta-3¹
KCNA3.1B²

External Ids:	HGNC: 6230¹	Entrez Gene: 9196²	Ensembl: ENSG00000170049⁷	OMIM: 604111⁵	UniProtKB: O43448³

Export aliases for KCNAB3 gene to outside databases

Previous GC identifers: GC17M008292 GC17M008697 GC17M007768 GC17M008026 GC17M007766 GC17M007720

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNAB3:

This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is

one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded

protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product

and regulates the activity of the alpha subunit. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448

Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters

the functional properties of Kv1.5

summary for KCNAB3:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNAB3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNAB3 gene promoter:
c-Fos Elk-1 AP-1 Sp1 NCX/Ncx Tal-1beta GATA-2 E47 c-Jun Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNAB3 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNAB3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

KCNAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNAB3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M007825: view genomic region (about GC identifiers)

Start:	7,825,177 bp from pter	End:	7,833,121 bp from pter
Size:	7,945 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448 (See protein sequence)

Recommended Name: Voltage-gated potassium channel subunit beta-3

Size: 404 amino acids; 43670 Da

Subunit: Forms heteromultimeric complex with alpha subunits

Subcellular location: Cytoplasm (Potential)

Secondary accessions: Q4VAW0

Explore the universe of human proteins at neXtProt for KCNAB3: NX_O43448

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43448

KCNAB3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004723.2

ENSEMBL proteins:

ENSP00000302719 ENSP00000458237 ENSP00000461290

Reactome Protein details: O43448
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: KCNAB3 OriGene Protein Over-expression Lysate: KCNAB3 OriGene Custom Protein Services for KCNAB3
	GenScript Custom Purified and Recombinant Proteins Services for KCNAB3
	Novus Biologicals KCNAB3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

KCNAB3 for ontologies About GeneDecksing

KCNAB3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCNAB3
	GenScript Custom Superior Antibodies Services for KCNAB3
	Novus Biologicals KCNAB3 Antibody
	Search for Antibodies for KCNAB3 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for KCNAB3

Assay Products for KCNAB3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNAB3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNAB3 for domains About GeneDecksing

5 InterPro domains/families:

IPR001395 Aldo/ket_red

IPR023210 NADP_OxRdtase_dom

IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel

IPR005402 K_chnl_volt-dep_bsu_KCNAB3

IPR005983 K_chnl_volt-dep_bsu_KCNAB

Graphical View of Domain Structure for InterPro Entry O43448

ProtoNet protein and cluster: O43448

2 Blocks protein families:

IPB001395 Aldo/keto reductase

IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448

Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit

(Probable)

Similarity: Belongs to the shaker potassium channel beta subunit family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448

Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters

the functional properties of Kv1.5

Genatlas biochemistry entry for KCNAB3:

potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in the brain and,predominantly in the

cerebellum,auxiliary beta 3 cytoplasmic peptide,co assembly in the endoplasmic reticulum with the channel forming

alpha subunits

miRNA Products:		OriGene 3'-UTR Clone: KCNAB3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNAB3
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNAB3 (see all 9):
		hsa-miR-1206 hsa-miR-663 hsa-miR-3201 hsa-miR-1908 hsa-miR-1203 hsa-miR-744 hsa-miR-135b hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: KCNAB3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB3 (see all 7) OriGene shRNA RFP: KCNAB3 OriGene siRNA: KCNAB3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCNAB3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNAB3 (NM_004732)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNAB3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNAB3
		Search LifeMap BioReagents cell lines for KCNAB3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0015459	potassium channel regulator activity	TAS	9857044

KCNAB3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KCNAB3:

Increased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Potassium Channels

Potassium Channels

1.00

Voltage gated Potassium channels

0.43

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

1.00

Transmission across Chemical Synapses

Neuronal System

0.67

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNAB3

Dopamine-DARPP32 Feedback onto cAMP Pathway

1 BioSystems Pathway for KCNAB3

metapathway biotransformation

3 Reactome Pathways for KCNAB3

	Potassium Channels
	Neuronal System
	Voltage gated Potassium channels

KCNAB3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCNAB3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for KCNAB3 (ENSP00000302719⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNA10	ENSP00000358786⁴	STRING: ENSP00000358786
KCNA2	ENSP00000314520⁴	STRING: ENSP00000314520
KCNA3	ENSP00000358784⁴	STRING: ENSP00000358784
KCNA4	ENSP00000328511⁴	STRING: ENSP00000328511
KCNA5	ENSP00000252321⁴	STRING: ENSP00000252321

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	9857044
GO:0007268	synaptic transmission	TAS	--

KCNAB3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNAB3 available from Tocris Bioscience About this table

Compound	Action	CAS #
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

Search CenterWatch for drugs/clinical trials and news about KCNAB3 / KCAB3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNAB3 gene:

NM_004732.3

Unigene Cluster for KCNAB3:

Potassium voltage-gated channel, shaker-related subfamily, beta member 3

Hs.435074 [show with all ESTs]

Unigene Representative Sequence: NM_004732

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303790(uc002gjm.1) ENST00000572275 ENST00000570587(uc010vul.1)

ENST00000576981 ENST00000574006 ENST00000570852

miRNA Products:		OriGene 3'-UTR Clone: KCNAB3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNAB3
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNAB3 (see all 9):
		hsa-miR-1206 hsa-miR-663 hsa-miR-3201 hsa-miR-1908 hsa-miR-1203 hsa-miR-744 hsa-miR-135b hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: KCNAB3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB3 (see all 7) OriGene shRNA RFP: KCNAB3 OriGene siRNA: KCNAB3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNAB3 (NM_004732)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNAB3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNAB3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB3

Additional cDNA sequence:

AF016411.1 AK309378.1 AK309807.1 BC096232.1 BC096234.3 BC099634.1

4 DOTS entries:

DT.65287315 DT.40255353 DT.40255364 DT.99933479

24/384 AceView cDNA sequences (see all 384):

BM788121 CA411962 BM790667 AA634456 CA423242 BQ001664 AW517041 AI672645

T36039 BU944766 BM708261 AA324507 BM556844 BM091038 H02021 CB243637

BM663873 BM694295 BQ649774 CD360014 AA167646 CB136728 CD672530 BM272622

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB3 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:			-		-								-
SP2:																					-
SP3:													-
SP4:

ECgene alternative splicing isoforms for KCNAB3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNAB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTACTCGC

About this image

KCNAB3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNAB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNAB3

SOURCE GeneReport for Unigene cluster: Hs.435074

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448

Tissue specificity: Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex,

occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas,

placenta and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including KCNAB3:

Neuronal Ion Channels in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNAB3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for KCNAB3 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	KCNAB3⁶	--	84(a)	1 ↔ 1	GL343784.1(12542-31422)
African clawed frog (Xenopus laevis)	Amphibia	AF172145.1²	--	74.61(n)		AF172145.1
zebrafish (Danio rerio)	Actinopterygii	LOC100334158¹	voltage-gated potassium channel subunit beta-3-like	68.42(n) 74.69(a)		100334158 XM_002662191.2 XP_002662237.2
fruit fly (Drosophila melanogaster)	Insecta	Hk³	potassium ion transport voltage-gated potassium more	45(a)		1 9B5 --
thale cress (Arabidopsis thaliana)	eudicotyledons	KAB1⁶	potassium channel beta subunit 1	45(a)	1 → many	1(1313564-1315750)
rice (Oryza sativa)	Liliopsida	--	oxidoreductase, aldo/keto reductase family protein...	46(a)	1 → many	2(35062107-35066744)
E. coli (Escherichia coli)	Gamma proteobacteria	gpr⁶ ydjG⁶	L-glyceraldehyde 3-phosphate reductase alpha-Keto reductase, NADH-dependent; can use meth...	29(a) 24(a)	possible ortholog possible ortholog	Chromosome(3145919-3146959) Chromosome(1853015-1853995)

ENSEMBL Gene Tree for KCNAB3 (if available)
TreeFam Gene Tree for KCNAB3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNAB3 gene

KCNAB1² AKR7A3² AKR7A2² KCNAB2²

2 SIMAP similar genes for KCNAB3 using alignment to 3 protein entries: KCAB3_HUMAN (see all proteins):

KCNAB2 KCNAB1

KCNAB3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73235704^1,2	C,	--	7728274(+)	`GTGACA/TAAAAG`	2	--	us2k¹		3		WA CSA	121
rs1128814^1,2	C	--	7728605(-)	`TGGGCC/AAAACT`	2	--	us2k¹		2		NA	4
rs113714495^1,2	C	--	7728653(+)	`CAGCTA/C/TTGGAA`	2	--	us2k¹		1		CSA	1
rs112108217^1,2	C	--	7728926(+)	`ACTGAG/CCGCAC`	2	--	us2k¹		1		CSA	1
rs76418405^1,2	C,	--	7729043(+)	`AGTTTG/TGAAGG`	2	--	us2k¹		0	--	--	--	--
rs111646343^1,2	C	--	7729066(+)	`CCTTCA/C/GTGCAG`	2	--	us2k¹		1		CSA	1
rs58357062^1,2	C,F,	--	7729327(+)	`CCCTCT/CGGAGG`	2	--	us2k¹		1		WA	118
rs181122770^1,2		--	7824799(+)	`GTTGGC/GTGCTA`	1	--	ds500¹		0	--	--	--	--
rs75019467^1,2		--	7824854(+)	`GTTTTA/GCTTTG`	1	--	ds500¹		0	--	--	--	--
rs117155088^1,2	F,	--	7824863(+)	`TGCTTG/TCCCAG`	1	--	ds500¹		1		NA	120

HapMap Linkage Disequilibrium report for KCNAB3 (7825177 - 7833121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNAB3: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB3

DNA2.0 Custom Variant and Variant Library Synthesis for KCNAB3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNAB3 for disorders           About GeneDecksing

OMIM gene information: 604111    OMIM disorders: --

5 diseases for KCNAB3:    About MalaCards

retinitis tuberculosis malaria alcoholism

mycobacterium tuberculosis

Export disorders for KCNAB3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNAB3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KCNAB3)

Utopia: connect your pdf to the dynamic
world of online information

Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. (PubMed id 9857044)^{1, 2, 3, 9} Leicher T.... Pongs O. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)¹ Persaud A....Rotin D. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)¹ Mccormack K.... Stuehmer W. (1995)
Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle. (PubMed id 7631872)⁹ Castellino R.C....Rasmusson R.L. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9196	HGNC: 6230	AceView: KCNAB3andTRAPPC1	Ensembl:ENSG00000170049	euGenes: HUgn9196
ECgene: KCNAB3	H-InvDB: KCNAB3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNAB3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNAB3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNAB3 gene:
Search GeneIP for patents involving KCNAB3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KCNAB3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB3
	OriGene Protein Over-expression Lysate for KCNAB3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KCNAB3		OriGene 3'-UTR Clone for KCNAB3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for KCNAB3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCNAB3		OriGene Custom Protein Services for KCNAB3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNAB3
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB3

	GenScript Custom Purified and Recombinant Proteins Services for KCNAB3		GenScript cDNA clones with any tag delivered in your preferred vector for KCNAB3
	GenScript Custom Assay Services for KCNAB3		GenScript Custom Superior Antibodies Services for KCNAB3
	GenScript Custom overexpressing Cell Line Services for KCNAB3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNAB3 promoter
	Search Chromatin IP Primers for KCNAB3
	RT² qPCR Primer Assay in human, mouse, rat KCNAB3
	Search GNC Networks for KCNAB3
	SABiosciences PCR Arrays including human, mouse, rat KCNAB3

Tocris compounds for KCNAB3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCNAB3 antibodies
	KCNAB3 lysates

	Search for Antibodies for KCNAB3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KCNAB3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for KCNAB3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB3

	SwitchGear 3'UTR luciferase reporter plasmids for KCNAB3
	SwitchGear Promoter luciferase reporter plasmids for KCNAB3

Search ThermoFisher Antibodies for KCNAB3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCNAB3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KCNAB3 Gene

potassium voltage-gated channel, shaker-related subfamily,...

Aliases
for KCNAB3 gene

Summaries
for KCNAB3 gene

Genomic Views
for KCNAB3 gene

Proteins
for KCNAB3 gene

Protein Domains /
Families
for KCNAB3 gene

Function
for KCNAB3 gene

Pathways & Interactions
for KCNAB3 gene

Drugs & Compounds
for KCNAB3 gene

Transcripts
for KCNAB3 gene

Expression
for KCNAB3 gene

Orthologs
for KCNAB3 gene

Paralogs
for KCNAB3 gene

Genomic Variants
for KCNAB3 gene

Disorders / Diseases
for KCNAB3 gene

Publications
for KCNAB3 gene

External Searches for KCNAB3 gene

Genome Databases showing KCNAB3 gene

Other Databases showing KCNAB3 gene

Specialized Databases showing KCNAB3 gene

Intellectual Property
for KCNAB3 gene

Products
for KCNAB3 gene

View Random Gene

Advanced Search

Export list of displayed genes

KCNAB3 Gene

potassium voltage-gated channel, shaker-related subfamily,...

Aliasesfor KCNAB3 gene

Summariesfor KCNAB3 gene

Genomic Viewsfor KCNAB3 gene

Proteinsfor KCNAB3 gene

Protein Domains /Familiesfor KCNAB3 gene

Functionfor KCNAB3 gene

Pathways & Interactionsfor KCNAB3 gene

Drugs & Compoundsfor KCNAB3 gene

Transcriptsfor KCNAB3 gene

Expression for KCNAB3 gene

Orthologsfor KCNAB3 gene

Paralogsfor KCNAB3 gene

Genomic Variantsfor KCNAB3 gene

Disorders / Diseasesfor KCNAB3 gene

Publicationsfor KCNAB3 gene

External Searches for KCNAB3 gene

Genome Databases showing KCNAB3 gene

Other Databases showing KCNAB3 gene

Specialized Databases showing KCNAB3 gene

Intellectual Propertyfor KCNAB3 gene

Productsfor KCNAB3 gene

View Random Gene

Aliases
for KCNAB3 gene

Summaries
for KCNAB3 gene

Genomic Views
for KCNAB3 gene

Proteins
for KCNAB3 gene

Protein Domains /
Families
for KCNAB3 gene

Function
for KCNAB3 gene

Pathways & Interactions
for KCNAB3 gene

Drugs & Compounds
for KCNAB3 gene

Transcripts
for KCNAB3 gene

Expression
for KCNAB3 gene

Orthologs
for KCNAB3 gene

Paralogs
for KCNAB3 gene

Genomic Variants
for KCNAB3 gene

Disorders / Diseases
for KCNAB3 gene

Publications
for KCNAB3 gene

Intellectual Property
for KCNAB3 gene

Products
for KCNAB3 gene