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KCNAB3 Gene

protein-coding   GIFtS: 51

GC17M007766
potassium voltage-gated channel, shaker-related subfamily, beta member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AKR6A9 1, 2
KCNA3.1B 2
KCNA3B 1, 2, 3, 5
KV-BETA-3 2
Kv-beta-3 3
MGC116886 2
Descriptions
K(+) channel subunit beta-3 3
K+ channel beta-3 subunit 2
potassium channel, voltage-dependent, beta-3 subunit 2
potassium voltage-gated channel, shaker-related subfamily,
beta member 3 2
External Ids
HGNC: 62301
Entrez Gene: 91962
UniProtKB: O434483
Ensembl: ENSG000001700497
Search outside databases for aliases for KCNAB3 gene

Previous GC identifers: GC17M008292 GC17M008697 GC17M007768 GC17M008026

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNAB3:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion
channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the
potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta
subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member
and the KCNA5 gene product assemble into a heteromultimeric A-type channel that inactivates
completely and is significantly faster than other A-type Kv channels. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448
Function: Accessory potassium channel protein which modulates the activity of the pore-forming
alpha subunit. Alters the functional properties of Kv1.5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNAB3 gene  

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

KCNAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007766:     (about GC identifiers)

Start:
7,766,752 bp from pter
End:
7,773,478 bp from pter
Size:
6,727 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010718.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448 (See protein sequence)
Recommended Name: Voltage-gated potassium channel subunit beta-3  
Size: 404 amino acids; 43670 Da
Subunit: Forms heteromultimeric complex with alpha subunits
Subcellular location: Cytoplasm (Potential)
Secondary accessions: Q4VAW0

REFSEQ proteins: NP_004723.2  

ENSEMBL proteins: 
ENSP00000302719 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (KCNAB3)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0016021 integral to membrane IEA--
About this table

Antibodies for KCNAB3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for KCNAB3
Browse R&D Systems for Antibodies
Antibodies from Abcam (KCNAB3), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KCNAB3

Assays for KCNAB3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro domains/families:
 IPR001395 Aldo/ket_red
 IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
 IPR005402 K_chnl_volt-dep_bsu_KCNAB3
 IPR005983 K_chnl_volt-dep_bsu_KCNAB


   GeneDecks  KCNAB3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O43448

ProtoNet protein and cluster: O43448

2 Blocks protein families:
IPB001395 Aldo/keto reductase
IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature


UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448
Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain
of beta subunit (Probable)
Similarity: Belongs to the shaker potassium channel beta subunit family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNAB3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNAB3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004732

              Applied Biosystems Silencer® siRNAs for KCNAB3

              Sigma-Aldrich siRNA and siRNA Panels for KCNAB3  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNAB3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for KCNAB3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004732
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004732
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004732 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004732

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448
Function: Accessory potassium channel protein which modulates the activity of the pore-forming
alpha subunit. Alters the functional properties of Kv1.5

Genatlas biochemistry entry for KCNAB3:
potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in the brain
and,predominantly in the cerebellum,auxiliary beta 3 cytoplasmic peptide,co assembly in the
endoplasmic reticulum with the channel forming alpha subunits

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity IEA--
GO:0015459 potassium channel regulator activity TAS9857044
GO:0016491 oxidoreductase activity IEA--
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport TAS9857044
GO:0055114 oxidation reduction IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCNAB3 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNAB3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNAB3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004732

              Sigma-Aldrich siRNA and siRNA Panels for KCNAB3  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNAB3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004732  

REFSEQ mRNAs for KCNAB3 gene: 

NM_004732.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004732  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004732
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004732
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004732 

Additional cDNA sequence: 

AF016411.1 AK309378.1 AK309807.1 BC096232.1 BC096234.3 BC099634.1 

4 DOTS entries:

DT.65287315  DT.40255353  DT.40255364  DT.99933479 

24/384 AceView cDNA sequences (see all 384 ):

AA133344 CD672530 AI192586 BM663873 BU944766 BM708341 BM708261 BQ776624 
H02021 CR612174 BQ277958 CA841706 BU171673 BM091038 BM790667 BU729286 
H92563 BM811338 BM671333 CA411962 BM762006 BI767775 BQ186900 AA455789 

highest scoring ESTs for KCNAB3:

AF016411 AI090408 DA079107 DA087088 DA493633 DA800702 DB172236 AA716741 AI092060 AI208219 

Unigene Cluster for KCNAB3:

Potassium voltage-gated channel, shaker-related subfamily, beta member 3
Hs.435074  [show with all ESTs]
Unigene Representative Sequence: NM_004732


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB3

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1:        -     -                       -                                                                     
SP2:                                                              -                                             
SP3:                                      -                                                                     
SP4:                                                                                                            

About this scheme

ECgene alternative splicing isoforms for KCNAB3

1 Ensembl transcript including schematic representation:
ENST00000303790  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNAB3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCNAB3

1 / 2 / 3

2 probe-sets matching KCNAB3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

221413_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004732 0.60 0.83 0.73 1

221413_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGCTACTCGC

SOURCE GeneReport for Unigene cluster: Hs.435074

UniProtKB/Swiss-Prot: KCAB3_HUMAN, O43448
Tissue specificity: Brain specific. Most prominent expression in cerebellum. Weaker signals
detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord,
heart, lung, liver, kidney, pancreas, placenta and skeletal muscle

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCNAB3 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNAB31   -- potassium voltage-gated channel, shaker-related subfamily, more 91.91(n)
96.53(a)
489483  XM_546601.2  XP_546601.2 
chimpanzee
(Pan troglodytes)
KCNAB31   -- potassium voltage-gated channel, shaker-related subfamily, more 99.59(n)
99.75(a)
455208  XM_001172327.1  XP_001172327.1 
rat
(Rattus norvegicus)
Kcnab31   -- potassium voltage-gated channel, shaker-related subfamily, more 89.44(n)
92.33(a)
58981  NM_031652.1  NP_113840.1 
mouse
(Mus musculus)
Kcnab31, 5 115
potassium voltage-gated channel, shaker-related subfamily, more1, 5 88.37(n)1
92.82(a)1
164991  NM_010599.31  NP_034729.21 
 AI8431925  AK0297505  (see all 15)
fruit fly
(Drosophila melanogaster)
Hk3 1 9B5 potassium ion transport voltage-gated
potassium more
45(a)   --
About this table        Species with no ortholog for KCNAB3

ENSEMBL Gene Tree for KCNAB3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCNAB3 gene
KCNAB12  KCNAB22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/34 NCBI SNPs in KCNAB3 are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 30)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs98910061,2
A,C,F,H7766299(+) TTAGGG/TTTATT 1 -- ng5116Minor allele frequency- T:0.31EU EA WA NA 1620
rs98989551,2
A,C7773491(+) GGCCGA/GGGCGG 1 -- ng310--------
rs99081391,2
A,C,F,H7771335(+) CCCTGA/GGGTCC 1 -- int14Minor allele frequency- G:0.43EU EA WA 412
rs80702121,2
C,F,H7770653(+) CACTTG/ATGACA 1 -- int18Minor allele frequency- A:0.17EU EA WA 836
--
rs43965851,2
A,C7769595(+) aaaaaA/GaaTTC 1 -- int1 trp30--------
--
rs108528941,2
A,C7769283(+) AGAATG/TCAGGC 1 -- int10--------
--
rs44443951,2
A,C7769000(+) cccagA/Gctgtt 1 -- int10--------
--
rs718391951,2
--7766526(+) GTGCT-/ATT   
   ACATT
TCCCT
1 -- ng510--------
--
rs348702491,2
--7773337(+) GACCC-/CTCCAC 1 G/G fra10--------
--
rs99123171,2
--7766420(+) CTGCCC/TGTGAC 1 -- ng51 ese30--------
About this table

HapMap Linkage Disequilibrium images for KCNAB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604111

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for KCNAB3 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9196 HGNC: 6230 AceView: KCNAB3andTRAPPC1 Ensembl:ENSG00000170049 euGenes: HUgn9196
ECgene: KCNAB3 H-InvDB: KCNAB3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCNAB3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for KCNAB3 Antibodies for KCNAB3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCNAB3 Browse small molecules at Sigma-Aldrich
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