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KCNAB2 Gene

protein-coding GIFtS: 63

GC01P006020

potassium voltage-gated channel, shaker-related subfamily, beta member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AKR6A5 ^¹, ²
HKvbeta2 ^², ³
HKvbeta2.1 ^¹, ²
HKvbeta2.2 ^¹, ²
KCNA2B ^¹, ², ³, ⁵
KCNK2 ^³
KV-BETA-2 ^²
Kv-beta-2 ^³
MGC117289 ^²
OTTHUMP00000000874 ^²
OTTHUMP00000000875 ^²
OTTHUMP00000000877 ^²

Descriptions
K(+) channel subunit beta-2 ^³
K+ channel beta-2 subunit ^²
potassium channel shaker chain beta 2 ^²
potassium voltage-gated channel, shaker-related subfamily, beta member 2 ^²

External Ids
HGNC: 6229¹
Entrez Gene: 8514²
UniProtKB: Q13303³
Ensembl: ENSG00000069424⁷

Search outside databases for aliases for KCNAB2 gene

Previous GC identifers: GC01P005677 GC01P005909 GC01P005795

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNAB2:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four

sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in

Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the

potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta

subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member

alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results

in two transcript variants encoding distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303

Function: Accessory potassium channel protein which modulates the activity of the pore-forming

alpha subunit. Alters functional properties of Kv1.4

Gene Wiki entry for KCNAB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNAB2 gene

Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.3

KCNAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P006020: (about GC identifiers)

Start:	5,974,113 bp from pter
End:	6,083,840 bp from pter
Size:	109,728 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021937.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303 (See protein sequence)

Recommended Name: Voltage-gated potassium channel subunit beta-2

Size: 367 amino acids; 41000 Da

Subunit: Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1

and PRKCZ (By similarity)

Subcellular location: Cytoplasm (Potential)

PDB structures from and Proteopedia :

1ZSX (3D)

Secondary accessions: A0AVM9 O43659 Q5TG82 Q5TG83 Q99411

Alternative splicing: 2 isoforms: Q13303-1 Q13303-2

Post-translational modifications:

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and

SQSTM1 (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003627.1 NP_742128.1

ENSEMBL proteins:

ENSP00000367323 ENSP00000164247 ENSP00000367332 ENSP00000367337 ENSP00000340824 ENSP00000367351

ENSP00000318772 ENSP00000367327

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kv beta 2)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Proteins (see all 2): KCNAB2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for KCNAB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KCNAB2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kv beta 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCNAB2

Assays for KCNAB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13303

ProtoNet protein and cluster: Q13303

3 Blocks protein families:

IPB001395 Aldo/keto reductase

IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature

IPB005401 KCNAB voltage-gated K+ channel beta-2 subunit signature

UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303

Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain

of beta subunit (Probable)

Similarity: Belongs to the shaker potassium channel beta subunit family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNAB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNAB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003636

Applied Biosystems Silencer® siRNAs for KCNAB2

Sigma-Aldrich siRNA and siRNA Panels for KCNAB2

Sigma-Aldrich shRNA Panels and shRNA for KCNAB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003636
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003636
untagged cDNA clones in CMV expression vector (see all 3): NM_003636

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003636

UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303

Function: Accessory potassium channel protein which modulates the activity of the pore-forming

alpha subunit. Alters functional properties of Kv1.4

Genatlas biochemistry entry for KCNAB2:

potassium voltage-gated channel,Drosophila shaker-related subfamily,mainly expressed in the

brain,auxiliary beta 2 cytoplasmic peptide,co assembly in the endoplasmic reticulum with the

channel forming alpha subunits,modulating the amplitude of K+ currents

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnab2):

behavior/neurological	growth/size	homeostasis/metabolism	life span-post-weaning/aging	nervous system
normal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0015459	potassium channel regulator activity	TAS	7649300
GO:0016491	oxidoreductase activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/21 Interacting proteins for KCNAB2 (ENSP00000367323³ Q13303²) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²	MINT-2865350
KCNA2	ENSP00000314520³	STRING (score=.995)
KCNA1	ENSP00000228858³	STRING (score=.968)
KCNA4	ENSP00000328511³	STRING (score=.966)
KCNA5	ENSP00000252321³	STRING (score=.96)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNAB2

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNAB2 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNAB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNAB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003636

Sigma-Aldrich siRNA and siRNA Panels for KCNAB2

Sigma-Aldrich shRNA Panels and shRNA for KCNAB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003636 NM_172130

REFSEQ mRNAs for KCNAB2 gene (2 alternative transcripts):

NM_003636.2 NM_172130.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003636 NM_172130

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003636
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003636
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003636

Additional cDNA sequence:

AF029749.1 AF044253.1 AK124696.1 AK131252.1 AK289819.1 AK290044.1 AK312395.1 AK312871.1

AK315811.1 AK315858.1 BC110351.1 BC126424.1 BC130413.1 CR542264.1 CR542287.1 CR592084.1

U33429.1

24/26 DOTS entries (see all 26 ):

DT.95370268 DT.97802184 DT.95219163 DT.101981038 DT.99957606 DT.100779762 DT.100779755 DT.99975570

DT.452418 DT.121349996 DT.99987894 DT.97847082 DT.75103224 DT.121349988 DT.121350005 DT.121350014

DT.121349967 DT.121350015 DT.121350044 DT.121350082 DT.121350086 DT.40274591 DT.75195081 DT.95193951

24/238 AceView cDNA sequences (see all 238 ):

BU171590 BG060109 BF724574 BQ053241 CB216399 BX644940 BU527642 BQ682316

AI261585 BI907219 BU183035 CR592084 BQ183094 BM925038 BU855894 AI371008

BI752232 BF507857 AL582057 AU143388 BF514486 AI056721 BE676803 BF977313

highest scoring ESTs for KCNAB2:

U33429 AA113961 AA807333 AF044253 AK124696 AK131252 AL048057 AL135276 AL520102 AL568526

Unigene Cluster for KCNAB2:

Potassium voltage-gated channel, shaker-related subfamily, beta member 2

Hs.440497 [show with all ESTs]

Unigene Representative Sequence: AK124696

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB2 (see all 14 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^
SP1:											-		-		-				-				-		-		-		-				-												-				-
SP2:																											-						-												-
SP3:					-		-		-		-		-		-				-				-		-		-		-				-												-				-
SP4:															-				-				-		-		-		-				-
SP5:					-		-		-		-		-		-				-		-		-		-		-		-				-

ExUns:	20	^	21	^	22a	·	22b	·	22c	^	23	^	24	^	25a	·	25b	^	26
SP1:					-
SP2:					-
SP3:					-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KCNAB2

8 Ensembl transcripts including schematic representations:

ENST00000378083 ENST00000164247 ENST00000378092 ENST00000378097 ENST00000341524 ENST00000378111

ENST00000352527 ENST00000378087

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNAB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNAB2

¹ / ² / ³

6 probe-sets matching KCNAB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31900_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.76	U33429	1.00	1.00	1.00	1
31901_at²^{, 3}	U95-A	1	0.88	1.00	0.92	1.25	AF044253	0.80	1.00	0.91	1
211791_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF044253	0.80	1.00	0.91	1
203402_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL520102	0.80	1.00	0.91	1
211791_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203402_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNAB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATAATGT

SOURCE GeneReport for Unigene cluster: Hs.440497
Expression variation in blood from EXPOLDB for KCNAB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNAB2 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNAB2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	92.82(n) 99.43(a)	489626 XM_853201.1 XP_858294.1
chimpanzee (Pan troglodytes)	KCNAB2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	97.16(n) 98.18(a)	745416 XM_001154295.1 XP_001154295.1
cow (Bos taurus)	KCNAB2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	92.64(n) 99.46(a)	541597 NM_001014383.1 NP_001014405.1
rat (Rattus norvegicus)	Kcnab2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	90.92(n) 98.91(a)	29738 NM_017304.1 NP_059000.1
mouse (Mus musculus)	Kcnab2^{1, 5}	4 (78.40 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	90.74(n)¹ 98.91(a)¹	16498¹ NM_010598.2¹ NP_034728.2¹ AK143166⁵ AK152613⁵ (see all 14)

About this table Species with no ortholog for KCNAB2

ENSEMBL Gene Tree for KCNAB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNAB2 gene

KCNAB1² KCNAB3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/414 NCBI SNPs in KCNAB2 are shown (see all 414 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 178)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1056860^1,2	A,C,F	6083463(+)	`GGAGGG/AGGTAT`	2	--	ng3¹ ese³		1		MN	184
	rs6688192^1,2	A,H	6008108(+)	`AGGGAG/TGAGGG`	2	--	ng5¹ trp³		4		EU EA WA	418
	rs3789527^1,2	A,C	6083457(-)	`CCTCCC/TGAGAG`	2	--	ng3¹ ese³		0	--	--	--	--
	rs1295105^1,2	C,F	6007979(-)	`GTGCCG/AGCCAC`	2	--	ng5¹		1		MN	184
	rs2229003^1,2	F	6064902(+)	`CAGCAG/AAAGTC`	2	K/E	mis¹		1		MN	38
	rs3789528^1,2	F	6083196(-)	`CAGTGG/AGTGGG`	2	--	ng3¹ ese³		1		EA	930
	rs1295106^1,2	C	6007940(-)	`GCCACA/CCCCGT`	2	--	ng5¹		0	--	--	--	--
	rs4908772^1,2	C	6081619(+)	`GGGCCA/GGCCTC`	2	--	ut3¹		0	--	--	--	--
--	rs2229002^1,2	A,F	6081149(+)	`CTGTCA/GTCTTC`	2	S/S	syn¹		18		MN EA EU WA NA	3078
--	rs2229004^1,2	F	6064916(+)	`GCAGCC/TGGCAA`	2	A/A	syn¹		1		MN	40

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HapMap Linkage Disequilibrium images for KCNAB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601142

Human Gene Mutation Database: KCNAB2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/19 PubMed articles for KCNAB2 gene (see all 19 ):

Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)^{1, 3, 4} Mccormack K.... Stuehmer W. (1995)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. (PubMed id 8838324)^{2, 3} Schultz D....McCormack K. (1996)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. (PubMed id 12431995)³ Croci C....Enz R. (2003)
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. (PubMed id 12893943)³ Gu C....Jan L.Y. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8514	HGNC: 6229	AceView: KCNAB2	Ensembl:ENSG00000069424	euGenes: HUgn8514
ECgene: KCNAB2	H-InvDB: KCNAB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNAB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNAB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNAB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNAB2		Antibodies for KCNAB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNAB2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Chimera RNAi (KCNAB2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Kv beta 2)
	Antibodies (Kv beta 2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for KCNAB2

	Drugs for KCNAB2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KCNAB2

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KCNAB2 Gene at Home site.
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KCNAB2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for KCNAB2

Summaries
for KCNAB2

Genomic Location
for KCNAB2

Proteins
for KCNAB2

Protein Domains/
Families
for KCNAB2

Gene Function
for KCNAB2

Pathways & Interactions
for KCNAB2

Drugs & Compounds
for KCNAB2

Transcripts
for KCNAB2

Expression
for KCNAB2

Orthologs
for KCNAB2

Paralogs
for KCNAB2

SNPs/Variants
for KCNAB2

Disorders & Mutations
for KCNAB2

Medical News
for KCNAB2

Publications
for KCNAB2

Search for KCNAB2

Genome Databases showing KCNAB2

Other Databases showing KCNAB2

Specialized Databases showing KCNAB2

Licensable Technologies
for KCNAB2

Services
for KCNAB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNAB2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor KCNAB2

Summariesfor KCNAB2

Genomic Locationfor KCNAB2

Proteinsfor KCNAB2

Protein Domains/Familiesfor KCNAB2

Gene Functionfor KCNAB2

Pathways & Interactionsfor KCNAB2

Drugs & Compoundsfor KCNAB2

Transcriptsfor KCNAB2

Expression for KCNAB2

Orthologsfor KCNAB2

Paralogsfor KCNAB2

SNPs/Variantsfor KCNAB2

Disorders & Mutationsfor KCNAB2

Medical Newsfor KCNAB2

Publicationsfor KCNAB2

Search for KCNAB2

Genome Databases showing KCNAB2

Other Databases showing KCNAB2

Specialized Databases showing KCNAB2

Licensable Technologiesfor KCNAB2

Servicesfor KCNAB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNAB2

Summaries
for KCNAB2

Genomic Location
for KCNAB2

Proteins
for KCNAB2

Protein Domains/
Families
for KCNAB2

Gene Function
for KCNAB2

Pathways & Interactions
for KCNAB2

Drugs & Compounds
for KCNAB2

Transcripts
for KCNAB2

Expression
for KCNAB2

Orthologs
for KCNAB2

Paralogs
for KCNAB2

SNPs/Variants
for KCNAB2

Disorders & Mutations
for KCNAB2

Medical News
for KCNAB2

Publications
for KCNAB2

Licensable Technologies
for KCNAB2

Services
for KCNAB2