KCNAB2 Gene
protein-coding GIFtS: 60
GCID: GC01P006020
|
|
potassium voltage-gated channel, shaker-related subfamily,...
| |
Aliases
for KCNAB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 21 2 | | KV-BETA-22 | | KCNA2B1 2 3 5 | | K+ Channel Beta-2 Subunit2 | | AKR6A51 2 | | Potassium Channel Shaker Chain Beta 22 | | HKvbeta2.11 2 | | Voltage-Gated Potassium Channel Subunit Beta-22 | | HKvbeta2.21 2 | | KCNK23 | | K(+) Channel Subunit Beta-22 3 | | Kv-Beta-21 | | HKvbeta22 | | HKvbeta22 |
Export aliases for KCNAB2 gene to outside databasesPrevious GC identifers: GC01P005677 GC01P005909 GC01P005795 GC01P005235 |
Summaries
for KCNAB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNAB2:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from bothfunctional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heartrate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cellvolume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified inDrosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteinsassociating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (provided byRefSeq, Dec 2010)
UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Altersfunctional properties of Kv1.4
 summary
for KCNAB2:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNAB2
|
Genomic Views
for KCNAB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNAB2 gene promoter:
SRF SRF (504 AA) NRSF form 1 NRSF form 2 AREB6 PPAR-gamma1 PPAR-gamma2 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNAB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.3KCNAB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P006020: view genomic region
(about GC identifiers)
Start:
|
6,051,526 bp from pter |
End:
|
6,161,253 bp from pter |
Size:
|
109,728 bases |
Orientation:
|
plus strand |
|
Proteins
for KCNAB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303 (See
protein sequence)Recommended Name: Voltage-gated potassium channel subunit beta-2 Size: 367 amino acids; 41000 Da
Subunit: Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ (Bysimilarity)
Subcellular location: Cytoplasm (Potential)
1 PDB 3D structure from  and Proteopedia  for KCNAB2:1ZSX (3D)
Secondary accessions: A0AVM9 A8K1A4 B0AZR7 O43659 Q5TG82 Q5TG83 Q6ZNE4 Q99411Alternative splicing: 4 isoforms: Q13303-1 Q13303-2 Q13303-3 Q13303-4 Explore the universe of human proteins at neXtProt for KCNAB2: NX_Q13303
Post-translational modifications:
Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13303
KCNAB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001186789.1 NP_001186790.1 NP_001186791.1 NP_001186792.1 NP_003627.1 NP_742128.1
ENSEMBL proteins: ENSP00000367351 ENSP00000367337 ENSP00000367332 ENSP00000398395 ENSP00000374283 ENSP00000400285 ENSP00000389151 ENSP00000164247 ENSP00000464860 ENSP00000465785 ENSP00000367327 ENSP00000340824 ENSP00000318772 ENSP00000367323 ENSP00000396167 Reactome Protein details: Q13303
Human Recombinant Protein Products for KCNAB2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KCNAB2 for ontologies About GeneDecksing
KCNAB2 Antibody Products:
Assay Products for KCNAB2: |
Protein
Domains /
Families
for KCNAB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNAB2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13303ProtoNet protein and cluster: Q13303 3 Blocks protein families: IPB001395 Aldo/keto reductase IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature IPB005401 KCNAB voltage-gated K+ channel beta-2 subunit signature
UniProtKB/Swiss-Prot: KCAB2_HUMAN, Q13303Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit(Probable)Similarity: Belongs to the shaker potassium channel beta subunit family |
Function
for KCNAB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCAB2_HUMAN, Q13303Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Altersfunctional properties of Kv1.4 Genatlas biochemistry entry for KCNAB2:potassium voltage-gated channel,Drosophila shaker-related subfamily,mainly expressed in the brain,auxiliary beta 2cytoplasmic peptide,co assembly in the endoplasmic reticulum with the channel forming alpha subunits,modulating theamplitude of K+ currents
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
KCNAB2 for ontologies About GeneDecksing
Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kcnab2):
KCNAB2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Kcnab2tm1Kmc for KCNAB2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): KCNAB2 (NM_001199860) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNAB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB2 |
|
Pathways & Interactions
for KCNAB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Antiarrhythmic Pathway, Pharmacodynamics | | | 3 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 4 | Transmission across Chemical Synapses | | | 5 | Biological oxidations | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNAB2
1  BioSystems Pathway for KCNAB2
3 
Reactome Pathways for KCNAB2
1  PharmGKB Pathway for KCNAB2
KCNAB2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNAB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/53 Interacting proteins for KCNAB2 (Q133032, 3 ENSP000001642474) via UniProtKB, MINT, STRING, and/or I2D (see all 53)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007268 | synaptic transmission |
TAS | -- | | GO:0051291 | protein heterooligomerization |
IEA | -- |
KCNAB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNAB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for KCNAB2 available from Tocris Bioscience About this table
1 HMDB Compound for KCNAB2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- |
Search CenterWatch for drugs/clinical trials and news about KCNAB2 / KCAB2
|
Transcripts
for KCNAB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNAB2 gene (6 alternative transcripts): NM_001199860.1 NM_001199861.1 NM_001199862.1 NM_001199863.1 NM_003636.3 NM_172130.2 Unigene Cluster for KCNAB2: Potassium voltage-gated channel, shaker-related subfamily, beta member 2 Hs.440497 [show with all ESTs]Unigene Representative Sequence: NM_00119986018/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000378111 ENST00000378097(uc009vlv.2 uc001alv.2 uc001alw.2)
ENST00000493807 ENST00000378092 ENST00000478098 ENST00000445501 ENST00000389632
ENST00000428161 ENST00000435937 ENST00000164247(uc001alx.2) ENST00000459822
ENST00000472700 ENST00000462676 ENST00000481789 ENST00000378087 ENST00000341524(uc001alu.3)
ENST00000352527 ENST00000378083(uc001aly.2 uc009vlw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): KCNAB2 (NM_001199860) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNAB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB2 |
Additional cDNA sequence: AF029749.1 AF044253.1 AK124696.1 AK131252.1 AK289819.1 AK290044.1 AK312395.1 AK312871.1 AK315811.1 AK315858.1 BC126424.1 BC130413.1 CR542264.1 CR542287.1 U33429.1 24/28 DOTS entries (see all 28): DT.95370268 DT.97802184 DT.95219163 DT.101981038 DT.99957606 DT.100779762 DT.100779755 DT.99975570 DT.452418 DT.121349996 DT.99987894 DT.97847082 DT.75103224 DT.121349988 DT.121350005 DT.121350014 DT.121349967 DT.121350015 DT.121350082 DT.121350086 DT.40274591 DT.75195081 DT.99949811 DT.102839668 24/238 AceView cDNA sequences (see all 238): BX644940 AW327942 NM_003636 AL582057 BU855894 BG060109 AU143388 AI056721 CR592084 AF029749 AI261585 AF044253 BM925038 BU171590 BF724574 NM_172130 BM467561 BF514486 BU183035 CB216399 BQ682316 BI752232 BQ053241 BI907219
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB2 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KCNAB2
|
Expression
for KCNAB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNAB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATAATGT
About this image
See KCNAB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNAB2
SOURCE GeneReport for Unigene cluster: Hs.440497
SABiosciences Expression via Pathway-Focused PCR Arrays including KCNAB2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNAB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB2 |
Orthologs
for KCNAB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for KCNAB2 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNAB21 |
potassium voltage-gated channel, shaker-related subfamily, more |
85.38(n)
93.98(a) |
|
396068 XM_003642509.1 XP_003642557.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.14072 |
Xenopus laevis potassium channel beta 2 subunit mRNA, more |
79.13(n) |
|
AF172144.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
kcnab21 |
potassium voltage-gated channel, shaker-related subfamily, more |
76.95(n)
87.95(a) |
|
797337 XM_002663828.2 XP_002663874.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hk3 |
potassium ion transport voltage-gated
potassium more |
49(a) |
|
1 9B5 -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
KAB16 |
potassium channel beta subunit 1 |
49(a) |
1 → many |
1(1313564-1315750) |
rice
(Oryza sativa) |
Liliopsida |
AK072707.12 |
-- |
75.33(n) |
|
AK072707.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
gpr6ydjG6 |
L-glyceraldehyde 3-phosphate reductasealpha-Keto reductase, NADH-dependent; can use meth... |
29(a)26(a) |
possible orthologpossible ortholog |
Chromosome(3145919-3146959) Chromosome(1853015-1853995) |
ENSEMBL Gene Tree for KCNAB2 (if available)
TreeFam Gene Tree for KCNAB2 (if available) |
Paralogs
for KCNAB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNAB2 gene
- KCNAB12 AKR7A32 KCNAB32 AKR7A22
2 SIMAP similar genes for KCNAB2 using alignment to 12 protein entries: KCAB2_HUMAN (see all proteins):KCNAB1 KCNAB3
KCNAB2 for paralogs About GeneDecksing
|
Genomic Variants
for KCNAB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNAB2 (6051526 - 6161253 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNAB2
1 CNV: 4199
Human Gene Mutation Database (HGMD): KCNAB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB2 |
|
Disorders
/ Diseases
for KCNAB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNAB2 for disorders About GeneDecksing
OMIM gene information: 601142
OMIM disorders: --
8  diseases for KCNAB2: About MalaCardsepisodic ataxia neuronitis huntington's disease ataxia
tuberculosis malaria alcoholism mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for KCNAB2:Episodic ataxia Export disorders for KCNAB2 gene to outside databases
|
Publications
for KCNAB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNAB2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with KCNAB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)1, 2, 9 Mccormack K.... Stuehmer W. (1995)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. (PubMed id 8838324)1, 3 Schultz D....McCormack K. (1996)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
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External Searches for KCNAB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing KCNAB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing KCNAB2 gene
(According to HUGE)
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Specialized Databases showing KCNAB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for KCNAB2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for KCNAB2 gene:
Search GeneIP for patents involving KCNAB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KCNAB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCNAB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB2 | | | OriGene Protein Over-expression Lysate for KCNAB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNAB2 | | OriGene 3'-UTR Clone for KCNAB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KCNAB2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNAB2 | | OriGene Custom Protein Services for KCNAB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNAB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB2 |
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 | | | KCNAB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KCNAB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB2 |
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