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Aliases for KCNAB1 Gene

Aliases for KCNAB1 Gene

  • Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 1 2 3
  • KCNA1B 3 4 6
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 1 2 3
  • K(+) Channel Subunit Beta-1 3 4
  • K+ Channel Beta1a Chain 2 3
  • KV-BETA-1 3 4
  • Voltage-Gated Potassium Channel Beta-1 Subunit 3
  • Voltage-Gated Potassium Channel Subunit Beta-1 3
  • Potassium Voltage-Gated Channel Beta Subunit 3
  • Potassium Channel Shaker Chain Beta 1a 3
  • Potassium Channel Beta3 Subunit 3
  • Potassium Channel Beta 3 Chain 3
  • EC 1.1.1.- 4
  • HKvBeta3 3
  • AKR6A3 3
  • Kvb1.3 3
  • HKvb3 3

External Ids for KCNAB1 Gene

Summaries for KCNAB1 Gene

Entrez Gene Summary for KCNAB1 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNAB1 Gene

KCNAB1 (Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Biological oxidations. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNAB2.

UniProtKB/Swiss-Prot for KCNAB1 Gene

  • Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

Tocris Summary for KCNAB1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNAB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNAB1 Gene

Genomics for KCNAB1 Gene

Genomic Location for KCNAB1 Gene

Start:
156,037,701 bp from pter
End:
156,539,138 bp from pter
Size:
501,438 bases
Orientation:
Plus strand

Genomic View for KCNAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNAB1 Gene

Regulatory Elements for KCNAB1 Gene

Proteins for KCNAB1 Gene

  • Protein details for KCNAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14722-KCAB1_HUMAN
    Recommended name:
    Voltage-gated potassium channel subunit beta-1
    Protein Accession:
    Q14722
    Secondary Accessions:
    • A8K9H8
    • A8KAD4
    • B3KPZ4
    • Q13031
    • Q13302
    • Q16547
    • Q6PI60
    • Q99869

    Protein attributes for KCNAB1 Gene

    Size:
    419 amino acids
    Molecular mass:
    46563 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (PubMed:9763623). Interacts with KCNA5 (PubMed:12130714). Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).

    Alternative splice isoforms for KCNAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNAB1 Gene

Proteomics data for KCNAB1 Gene at MOPED

Post-translational modifications for KCNAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNAB1 Gene

No data available for DME Specific Peptides for KCNAB1 Gene

Domains for KCNAB1 Gene

Gene Families for KCNAB1 Gene

HGNC:
  • AKR :Aldo-keto reductases
  • KCN :Potassium channels

UniProtKB/Swiss-Prot:

KCAB1_HUMAN
Domain:
  • The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.:
    • Q14722
Family:
  • Belongs to the shaker potassium channel beta subunit family.:
    • Q14722
genes like me logo Genes that share domains with KCNAB1: view

Function for KCNAB1 Gene

Molecular function for KCNAB1 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in heart,auxiliary beta 1cytoplasmic peptide,,co assembly in the endoplasmic reticulum with the channel forming alpha subunits,modulating the amplitude of K+ currents
UniProtKB/Swiss-Prot Function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

Enzyme Numbers (IUBMB) for KCNAB1 Gene

Gene Ontology (GO) - Molecular Function for KCNAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005515 protein binding --
GO:0015459 potassium channel regulator activity IDA 12130714
GO:0070402 NADPH binding IDA 17540341
genes like me logo Genes that share ontologies with KCNAB1: view
genes like me logo Genes that share phenotypes with KCNAB1: view

Animal Models for KCNAB1 Gene

MGI Knock Outs for KCNAB1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for KCNAB1 Gene

Localization for KCNAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNAB1 Gene

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269 PubMed:17540341}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNAB1 Gene COMPARTMENTS Subcellular localization image for KCNAB1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KCNAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IDA 17540341
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 17540341
genes like me logo Genes that share ontologies with KCNAB1: view

Pathways for KCNAB1 Gene

genes like me logo Genes that share pathways with KCNAB1: view

Pathways by source for KCNAB1 Gene

1 Qiagen pathway for KCNAB1 Gene
1 BioSystems pathway for KCNAB1 Gene

Gene Ontology (GO) - Biological Process for KCNAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 7499366
GO:0007268 synaptic transmission TAS --
GO:0007611 learning or memory IEA --
GO:0055085 transmembrane transport --
GO:0055114 oxidation-reduction process ISS --
genes like me logo Genes that share ontologies with KCNAB1: view

Compounds for KCNAB1 Gene

(5) Tocris Compounds for KCNAB1 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(1) Novoseek inferred chemical compound relationships for KCNAB1 Gene

Compound -log(P) Hits PubMed IDs
potassium 51.1 2
genes like me logo Genes that share compounds with KCNAB1: view

Transcripts for KCNAB1 Gene

Unigene Clusters for KCNAB1 Gene

Potassium voltage-gated channel, shaker-related subfamily, beta member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB1 Gene

No ASD Table

Relevant External Links for KCNAB1 Gene

GeneLoc Exon Structure for
KCNAB1
ECgene alternative splicing isoforms for
KCNAB1

Expression for KCNAB1 Gene

mRNA expression in normal human tissues for KCNAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNAB1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (8.4), Brain - Caudate (basal ganglia) (7.1), Artery - Tibial (7.0), and Brain - Nucleus accumbens (basal ganglia) (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNAB1 Gene

SOURCE GeneReport for Unigene cluster for KCNAB1 Gene Hs.654519

mRNA Expression by UniProt/SwissProt for KCNAB1 Gene

Q14722-KCAB1_HUMAN
Tissue specificity: In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.
genes like me logo Genes that share expressions with KCNAB1: view

Orthologs for KCNAB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KCNAB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNAB1 36
  • 93.68 (n)
  • 100 (a)
KCNAB1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNAB1 36
  • 92.1 (n)
  • 99 (a)
KCNAB1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnab1 36
  • 92.52 (n)
  • 99.75 (a)
Kcnab1 16
Kcnab1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNAB1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kcnab1 36
  • 92.52 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves KCNAB1 36
  • 82.71 (n)
  • 95.26 (a)
KCNAB1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNAB1 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnab1 36
  • 80.25 (n)
  • 92.25 (a)
Str.4507 36
zebrafish
(Danio rerio)
Actinopterygii kcnab1 36
  • 78.06 (n)
  • 88.94 (a)
kcnab1 37
  • 79 (a)
OneToMany
kcnab1 37
  • 91 (a)
OneToMany
KCNAB1 (2 of 3) 37
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010067 36
  • 55.29 (n)
  • 51.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hk 36
  • 54.1 (n)
  • 50.46 (a)
Hk 37
  • 25 (a)
OneToMany
Hk 38
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons KAB1 36
  • 52.29 (n)
  • 48.62 (a)
rice
(Oryza sativa)
Liliopsida Os02g0817500 36
  • 53.52 (n)
  • 50.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02887 36
  • 51.57 (n)
  • 47.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC965.06 36
  • 51.86 (n)
  • 46.58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3802 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToMany
Species with no ortholog for KCNAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNAB1 Gene

ENSEMBL:
Gene Tree for KCNAB1 (if available)
TreeFam:
Gene Tree for KCNAB1 (if available)

Paralogs for KCNAB1 Gene

Paralogs for KCNAB1 Gene

Selected SIMAP similar genes for KCNAB1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for KCNAB1 Gene

genes like me logo Genes that share paralogs with KCNAB1: view

Variants for KCNAB1 Gene

Sequence variations from dbSNP and Humsavar for KCNAB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs17170 -- 156,172,731(+) AGACA(A/G)GACAA intron-variant
rs376279 -- 156,196,453(-) tggaa(A/G)aacat intron-variant
rs400943 -- 156,196,415(-) tatcg(G/T)gaaaa intron-variant
rs478973 -- 156,298,050(-) ACTTT(A/G)AGGCA intron-variant
rs498033 -- 156,316,952(+) CCGTC(G/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNAB1 Gene

Variant ID Type Subtype PubMed ID
nsv4078 CNV Insertion 18451855
esv268340 CNV Insertion 20981092
esv2662315 CNV Deletion 23128226
esv2667743 CNV Deletion 23128226
nsv877682 CNV Gain 21882294
nsv4079 CNV Insertion 18451855
esv2620873 CNV Deletion 19546169
nsv513090 CNV Loss 21212237
esv2289616 CNV Deletion 18987734
esv28145 CNV Loss 19812545
esv2663886 CNV Deletion 23128226
nsv237787 CNV Loss 16902084
esv2726090 CNV Deletion 23290073
nsv822302 CNV Loss 20364138
esv2125528 CNV Deletion 18987734
nsv829764 CNV Gain 17160897
nsv877683 CNV Gain 21882294
esv271077 CNV Insertion 20981092
esv271162 CNV Insertion 20981092
esv272880 CNV Insertion 20981092
esv1546912 CNV Insertion 17803354

Relevant External Links for KCNAB1 Gene

HapMap Linkage Disequilibrium report
KCNAB1

Disorders for KCNAB1 Gene

(1) University of Copenhagen DISEASES for KCNAB1 Gene

Relevant External Links for KCNAB1

Genetic Association Database (GAD)
KCNAB1
Human Genome Epidemiology (HuGE) Navigator
KCNAB1
genes like me logo Genes that share disorders with KCNAB1: view

No data available for UniProtKB/Swiss-Prot for KCNAB1 Gene

Publications for KCNAB1 Gene

  1. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PMID: 7649300) Mccormack K. … Stuehmer W. (FEBS Lett. 1995) 3 4 23
  2. Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). (PMID: 8938711) Leicher T. … Pongs O. (Neuropharmacology 1996) 3 4 23
  3. A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. (PMID: 7499366) England S.K. … Tamkun M.M. (J. Biol. Chem. 1995) 2 3 4
  4. Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. (PMID: 7603988) England S.K. … Tamkun M.M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4
  5. Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. (PMID: 7890032) Majumder K. … Wible B.A. (FEBS Lett. 1995) 3 4

Products for KCNAB1 Gene

Sources for KCNAB1 Gene

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