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KCNAB1 Gene

protein-coding GIFtS: 62

GC03P157321

potassium voltage-gated channel, shaker-related subfamily, beta member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AKR6A3 ^¹, ²
KCNA1B ^¹, ², ³, ⁵
KV-BETA-1 ^²
Kv-beta-1 ^³
Kvb1.3 ^¹, ²
hKvBeta3 ^¹, ²
hKvb3 ^¹, ²

Descriptions
K(+) channel subunit beta-1 ^³
potassium channel beta 3 chain ^²
potassium channel beta3 subunit ^²
potassium channel shaker chain beta 1a ^²
potassium voltage-gated channel beta subunit ^²
potassium voltage-gated channel, shaker-related subfamily, beta member 1 ^²
voltage-gated potassium channel beta-1 subunit ^²

External Ids
HGNC: 6228¹
Entrez Gene: 7881²
UniProtKB: Q14722³
Ensembl: ENSG00000169282⁷

Search outside databases for aliases for KCNAB1 gene

Previous GC identifers: GC03P152874 GC03P156956 GC03P157119 GC03P157159

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNAB1:

Potassium channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter

release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport,

smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes -

shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have

human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,

shaker-related subfamily. This member includes three distinct isoforms which are encoded by three

alternatively spliced transcript variants of this gene. These three isoforms are beta subunits,

which form heteromultimeric complex with alpha subunits and modulate the activity of the

pore-forming alpha subunits. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722

Function: Accessory potassium channel protein which modulates the activity of the pore-forming

alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform

KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1

Gene Wiki entry for KCNAB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNAB1 gene

Entrez Gene cytogenetic band: 3q26.1 Ensembl cytogenetic band: 3q25.31 HGNC cytogenetic band: 3q26.1

KCNAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P157321: (about GC identifiers)

Start:	157,321,031 bp from pter
End:	157,739,621 bp from pter
Size:	418,591 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722 (See protein sequence)

Recommended Name: Voltage-gated potassium channel subunit beta-1

Size: 419 amino acids; 46563 Da

Subunit: Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity)

Subcellular location: Cytoplasm (Potential)

Secondary accessions: Q13031 Q13302 Q16547 Q6PI60 Q99869

Alternative splicing: 3 isoforms: Q14722-1 Q14722-2 Q14722-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_003462.2 NP_751891.1 NP_751892.1

ENSEMBL proteins:

ENSP00000374287 ENSP00000374285 ENSP00000305858 ENSP00000317378 ENSP00000374283

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kv beta 1)
	Human Recombinant Proteins from Abnova (KCNAB1)

OriGene Purified Recombinant Human Protein: KCNAB1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNAB1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KCNAB1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kv beta 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCNAB1

Assays for KCNAB1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14722

ProtoNet protein and cluster: Q14722

3 Blocks protein families:

IPB001395 Aldo/keto reductase

IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature

IPB005400 KCNAB voltage-gated K+ channel beta-1 subunit signature

UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722

Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain

of beta subunit (Probable)

Similarity: Belongs to the shaker potassium channel beta subunit family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNAB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNAB1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_172159

Applied Biosystems Silencer® siRNAs for KCNAB1

Sigma-Aldrich siRNA and siRNA Panels for KCNAB1

Sigma-Aldrich shRNA Panels and shRNA for KCNAB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNAB1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003471
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003471
untagged cDNA clones in CMV expression vector (see all 3): NM_003471

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_172160

UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722

Function: Accessory potassium channel protein which modulates the activity of the pore-forming

alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform

KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1

Genatlas biochemistry entry for KCNAB1:

potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in heart,auxiliary

beta 1cytoplasmic peptide,,co assembly in the endoplasmic reticulum with the channel forming alpha

subunits,modulating the amplitude of K+ currents

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnab1):

behavior/neurological

life span-post-weaning/aging

nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0015459	potassium channel regulator activity	TAS	7499366
GO:0016491	oxidoreductase activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Interacting proteins for KCNAB1 (ENSP00000305858³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNA2	ENSP00000314520³	STRING (score=.981)
KCNA4	ENSP00000328511³	STRING (score=.954)
KCNA5	ENSP00000252321³	STRING (score=.932)
KCNA1	ENSP00000228858³	STRING (score=.867)
KCNA3	ENSP00000358784³	STRING (score=.858)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	7499366
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNAB1

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNAB1 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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1 Novoseek chemical compound relationship for KCNAB1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	47.24	1	8938711 (1)

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1 PharmGKB drug compound relationship for KCNAB1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA GN	7603988

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNAB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNAB1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_172159

Sigma-Aldrich siRNA and siRNA Panels for KCNAB1

Sigma-Aldrich shRNA Panels and shRNA for KCNAB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003471 NM_172159 NM_172160

REFSEQ mRNAs for KCNAB1 gene (3 alternative transcripts):

NM_003471.3 NM_172159.3 NM_172160.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003471 NM_172159 NM_172160

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003471
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003471
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003471

Additional cDNA sequence:

AK057059.1 AK127240.1 AK292693.1 AK292999.1 AK296728.1 AK303287.1 AY780786.1 BC043166.2

CR605930.1 L39833.1 L47665.1 U16953.1 U17968.1 U33428.1

9 DOTS entries:

DT.414830 DT.100678459 DT.100743432 DT.95160478 DT.70105431 DT.97819777 DT.95251606 DT.120847313

DT.91867056

17 AceView cDNA sequences:

AI344124 AA101811 AI421570 AA307631 BU071950 AV690748 AI225105 CA433063

AW026476 BG927156 AI361306 CD695905 AI991486 BX106158 BF696512 AA101809

AV700268

highest scoring ESTs for KCNAB1:

L39833 AA013094 AA013095 AA301634 AA642687 AI090942 AI344124 AI361306 AI420137 AI421570

Unigene Cluster for KCNAB1:

Potassium voltage-gated channel, shaker-related subfamily, beta member 1

Hs.654519 [show with all ESTs]

Unigene Representative Sequence: NM_172159

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:

ENST00000389636 ENST00000389634 ENST00000302490 ENST00000320719 ENST00000389632

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNAB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNAB1

¹ / ² / ³

11 probe-sets matching KCNAB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32711_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.64	X83127	0.60	1.00	0.82	1
32709_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.88	L39833	1.00	1.00	1.00	1
32710_at*²^{, 3}	U95-A	1	1.00	1.00	0.13	1.53	X83127	0.60	1.00	0.82	1
210079_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U16953	0.80	1.00	0.91	1
210471_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U33428	0.80	1.00	0.91	1
208213_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003471	0.60	1.00	0.82	1
210078_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L39833	1.00	1.00	1.00	1
210079_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210471_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208213_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210078_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNAB1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACAGATTCGC

SOURCE GeneReport for Unigene cluster: Hs.654519
Expression variation in blood from EXPOLDB for KCNAB1
UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722
Tissue specificity: In brain, expression is most prominent in caudate nucleus, hippocampus and
thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed
in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than
left atrium

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNAB1 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNAB1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	92.1(n) 99(a)	612006 XM_849730.1 XP_854823.1
chimpanzee (Pan troglodytes)	KCNAB1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	96.06(n) 95.73(a)	740565 XM_001150240.1 XP_001150240.1
cow (Bos taurus)	KCNAB1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	93.68(n) 100(a)	526133 NM_001025336.1 NP_001020507.1
rat (Rattus norvegicus)	Kcnab1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	92.52(n) 100(a)	29737 NM_017303.2 NP_058999.1
mouse (Mus musculus)	Kcnab1^{1, 5}	3 (32.00 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	92.6(n)¹ 99.75(a)¹	16497¹ NM_010597.2¹ NP_034727.2¹ AF033003⁵ AK004666⁵ (see all 12)

About this table Species with no ortholog for KCNAB1

ENSEMBL Gene Tree for KCNAB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNAB1 gene

KCNAB3² KCNAB2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1984 NCBI SNPs in KCNAB1 are shown (see all 1984 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 741)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6786904^1,2	A,C,F,H	157319108(+)	`atcacA/Cgcact`	1	--	ng5¹		11	EU EA WA NA	978
	rs2290165^1,2	A,C,F,H	157492308(-)	`ATTTCC/TGCTTT`	3	--	int¹ ut5¹		11	EA NA WA	2262
	rs6775388^1,2	A,C,F,H	157319047(+)	`ttatcT/Gctatt`	1	--	ng5¹ tfbs³		7	EU EA WA NA	518
	rs4680237^1,2	A,C,F,H	157341807(+)	`gatgtA/Gaccac`	2	--	int¹ ng5¹		7	EU EA WA NA	560
	rs1027915^1,2	C,F,H,O	157738383(-)	`CAAGTT/CAATTT`	3	--	ut3¹ ese³		12	MN EU EA WA NA	1162
	rs907060^1,2	A,C,F,H	157737781(-)	`aaattC/AtttCT`	3	--	ut3¹		12	MN EU EA WA NA	1152
	rs6767209^1,2	C,F,H	157490667(+)	`AATATG/ACCTTC`	3	--	int¹ ng5¹		4	EU EA WA	410
--	rs1510278^1,2	C,F,H	157739815(-)	`CATCTA/GTCCAG`	3	--	ng3¹		5	MN EU EA WA	602
	rs992353^1,2	A,C,F	157739155(-)	`TACATA/GTGTAT`	3	--	ut3¹ ese³		7	NA EA MN	578
	rs10936027^1,2	C,F,H	157739101(+)	`TTTTAT/GCTGAT`	3	--	ut3¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for KCNAB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601141

Human Genome Epidemiology Navigator: KCNAB1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/22 PubMed articles for KCNAB1 gene (see all 22 ):

Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. (PubMed id 7603988)^{3, 4, 7} England S.K....Tamkun M.M. (1995)
A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. (PubMed id 7499366)^{2, 3, 4} England S.K....Tamkun M.M. (1995)
Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). (PubMed id 8938711)^{1, 3, 4} Leicher T.... Pongs O. (1996)
Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)^{1, 3, 4} Mccormack K.... Stuehmer W. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. (PubMed id 8838324)^{2, 3} Schultz D....McCormack K. (1996)
Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. (PubMed id 7890032)^{3, 4} Majumder K.... Wible B.A. (1995)
A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. (PubMed id 7890764)^{3, 4} Morales M.J....Strauss H.C. (1995)
Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. (PubMed id 9857044)^{1, 3} Leicher T.... Pongs O. (1998)
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. (PubMed id 18987637)³ Decher N....Sanguinetti M.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7881	HGNC: 6228	AceView: KCNAB1.1	Ensembl:ENSG00000169282	euGenes: HUgn7881
ECgene: KCNAB1	H-InvDB: KCNAB1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for KCNAB1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNAB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNAB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNAB1		Antibodies for KCNAB1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNAB1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KCNAB1)
	Search for Antibodies
	Chimera RNAi (KCNAB1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Kv beta 1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for KCNAB1

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KCNAB1 Gene at Home site.
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KCNAB1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for KCNAB1

Summaries
for KCNAB1

Genomic Location
for KCNAB1

Proteins
for KCNAB1

Protein Domains/
Families
for KCNAB1

Gene Function
for KCNAB1

Pathways & Interactions
for KCNAB1

Drugs & Compounds
for KCNAB1

Transcripts
for KCNAB1

Expression
for KCNAB1

Orthologs
for KCNAB1

Paralogs
for KCNAB1

SNPs/Variants
for KCNAB1

Disorders & Mutations
for KCNAB1

Medical News
for KCNAB1

Publications
for KCNAB1

Search for KCNAB1

Genome Databases showing KCNAB1

Other Databases showing KCNAB1

Specialized Databases showing KCNAB1

Licensable Technologies
for KCNAB1

Services
for KCNAB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNAB1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor KCNAB1

Summariesfor KCNAB1

Genomic Locationfor KCNAB1

Proteinsfor KCNAB1

Protein Domains/Familiesfor KCNAB1

Gene Functionfor KCNAB1

Pathways & Interactionsfor KCNAB1

Drugs & Compoundsfor KCNAB1

Transcriptsfor KCNAB1

Expression for KCNAB1

Orthologsfor KCNAB1

Paralogsfor KCNAB1

SNPs/Variantsfor KCNAB1

Disorders & Mutationsfor KCNAB1

Medical Newsfor KCNAB1

Publicationsfor KCNAB1

Search for KCNAB1

Genome Databases showing KCNAB1

Other Databases showing KCNAB1

Specialized Databases showing KCNAB1

Licensable Technologiesfor KCNAB1

Servicesfor KCNAB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNAB1

Summaries
for KCNAB1

Genomic Location
for KCNAB1

Proteins
for KCNAB1

Protein Domains/
Families
for KCNAB1

Gene Function
for KCNAB1

Pathways & Interactions
for KCNAB1

Drugs & Compounds
for KCNAB1

Transcripts
for KCNAB1

Expression
for KCNAB1

Orthologs
for KCNAB1

Paralogs
for KCNAB1

SNPs/Variants
for KCNAB1

Disorders & Mutations
for KCNAB1

Medical News
for KCNAB1

Publications
for KCNAB1

Licensable Technologies
for KCNAB1

Services
for KCNAB1