Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNAB1 Gene

protein-coding   GIFtS: 55
GCID: GC03P155755

potassium voltage-gated channel, shaker-related subfamily,...
 Explore 11 diseases affiliated with
KCNAB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNAB1    

Aliases
for KCNAB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 11 2     Potassium Channel Beta 3 Chain2
KCNA1B1 2 3 5     Potassium Channel Beta3 Subunit2
AKR6A31 2     Potassium Channel Shaker Chain Beta 1a2
Kvb1.31 2     Potassium Voltage-Gated Channel Beta Subunit2
HKvBeta31     Voltage-Gated Potassium Channel Beta-1 Subunit2
HKvb31     Voltage-Gated Potassium Channel Subunit Beta-12
K(+) Channel Subunit Beta-12 3     Kv-Beta-11
KV-BETA-12     

External Ids:    HGNC: 62281   Entrez Gene: 78812   Ensembl: ENSG000001692827   OMIM: 6011415   UniProtKB: Q147223   

Export aliases for KCNAB1 gene to outside databases

Previous GC identifers: GC03P152874 GC03P156956 GC03P157119 GC03P157159 GC03P157321 GC03P153234


Summaries
for KCNAB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNAB1:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each
has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively
spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex
with alpha subunits and modulate the activity of the pore-forming alpha subunits. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722
Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three
isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1

summary for KCNAB1:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNAB1


Genomic Views
for KCNAB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNAB1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   Tal-1beta   HNF-4alpha1   E2F   E2F-1   TGIF   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q26.1

KCNAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNAB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P155755:  view genomic region     (about GC identifiers)

Start:
 155,755,490 bp from pter      End:
 156,256,927 bp from pter
Size:
 501,438 bases      Orientation:
 plus strand

Proteins
for KCNAB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722 (See protein sequence)
Recommended Name: Voltage-gated potassium channel subunit beta-1  
Size: 419 amino acids; 46563 Da
Subunit: Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex
containing KCNA1, KCNA4 and LGI1 (By similarity)
Subcellular location: Cytoplasm (Potential)
Secondary accessions: A8K9H8 A8KAD4 B3KPZ4 Q13031 Q13302 Q16547 Q6PI60 Q99869
Alternative splicing: 3 isoforms:  Q14722-1   Q14722-2   Q14722-3   (Ref.9 (AAC50113) sequence is in conflict in position: 16:L->S)

Explore the universe of human proteins at neXtProt for KCNAB1: NX_Q14722

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14722

    • KCNAB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_003462.2  NP_751891.1  NP_751892.1  

    ENSEMBL proteins: 
     ENSP00000420755   ENSP00000419952   ENSP00000374287   ENSP00000418956   ENSP00000420221  
     ENSP00000305858   ENSP00000374285   ENSP00000418048  
    Reactome Protein details: Q14722
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: KCNAB1
    OriGene Protein Over-expression Lysate (see all 5): KCNAB1
    OriGene Custom Protein Services for KCNAB1 
    GenScript Custom Purified and Recombinant Proteins Services for KCNAB1
    Novus Biologicals KCNAB1 Protein
    Novus Biologicals KCNAB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    KCNAB1 for ontologies           About GeneDecksing



    KCNAB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 11): KCNAB1
    OriGene Custom Antibody Services for KCNAB1 
    GenScript Custom Superior Antibodies Services for KCNAB1
    Novus Biologicals KCNAB1 Antibodies
    Search for Antibodies for KCNAB1 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for KCNAB1

    Assay Products for KCNAB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNAB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for KCNAB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNAB1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001395 Aldo/ket_red
     IPR023210 NADP_OxRdtase_dom
     IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
     IPR005400 K_chnl_volt-dep_bsu_KCNAB1
     IPR005983 K_chnl_volt-dep_bsu_KCNAB

    Graphical View of Domain Structure for InterPro Entry Q14722

    ProtoNet protein and cluster: Q14722

    3 Blocks protein families:
    IPB001395 Aldo/keto reductase
    IPB005399 KCNAB voltage-gated K+ channel beta subunit family signature
    IPB005400 KCNAB voltage-gated K+ channel beta-1 subunit signature


    UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722
    Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit
    (Probable)
    Similarity: Belongs to the shaker potassium channel beta subunit family


    Function
    for KCNAB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722
    Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three
    isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1

         Genatlas biochemistry entry for KCNAB1:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,expressed in heart,auxiliary beta 1cytoplasmic
    peptide,,co assembly in the endoplasmic reticulum with the channel forming alpha subunits,modulating the amplitude of
    K+ currents

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): KCNAB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNAB1
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNAB1 (see all 49):
    hsa-miR-576-3p hsa-miR-4317 hsa-miR-15a hsa-miR-128 hsa-let-7a-2* hsa-miR-548l hsa-miR-424 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: KCNAB1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB1 (see all 7)
    OriGene shRNA RFP: KCNAB1
    OriGene siRNA: KCNAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KCNAB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): KCNAB1 (NM_172160)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KCNAB1
    Search LifeMap BioReagents cell lines for KCNAB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity IEA--
    GO:0005515protein binding ----
    GO:0015459potassium channel regulator activity TAS7499366


    KCNAB1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KCNAB1: Kcnab1tm1Sva Kcnab1tm1Mes Kcnab1tm1Kwak
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnab1):
     behavior/neurological  cardiovascular system  mortality/aging  nervous system 

    KCNAB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNAB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67
    4Biological oxidations
    		metapathway biotransformation0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNAB1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 BioSystems Pathway for KCNAB1 
        metapathway biotransformation

    3        Reactome Pathways for KCNAB1
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNAB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/27 Interacting proteins for KCNAB1 (Q147223 ENSP000004199524) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA2P163893, ENSP000003145204I2D: score=4 STRING: ENSP00000314520
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    SLC39A2Q9NP943, ENSP000002986814I2D: score=1 STRING: ENSP00000298681
    SLC39A1Q9NY263, ENSP000003097104I2D: score=1 STRING: ENSP00000309710
    ISCUQ9H1K13I2D: score=6 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS7499366
    GO:0007268synaptic transmission TAS--
    GO:0055085transmembrane transport ----


    KCNAB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNAB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNAB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    1 Novoseek chemical compound relationship for KCNAB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 51.1 3 19153714 (1), 8938711 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNAB1 / KCAB1 

    Transcripts
    for KCNAB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNAB1 gene (3 alternative transcripts): 
    NM_003471.3  NM_172159.3  NM_172160.2  

    Unigene Cluster for KCNAB1:

    Potassium voltage-gated channel, shaker-related subfamily, beta member 1
    Hs.654519  [show with all ESTs]
    Unigene Representative Sequence: NM_172159
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477912 ENST00000478609 ENST00000472028 ENST00000490337(uc003far.2 uc011bon.1)
    ENST00000389636 ENST00000471742(uc003fas.2) ENST00000475456 ENST00000302490(uc003fat.2 uc010hvt.1 uc011boo.1)
    ENST00000389634 ENST00000489036 ENST00000476362 ENST00000461717 ENST00000497291
    ENST00000496923

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): KCNAB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNAB1
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNAB1 (see all 49):
    hsa-miR-576-3p hsa-miR-4317 hsa-miR-15a hsa-miR-128 hsa-let-7a-2* hsa-miR-548l hsa-miR-424 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: KCNAB1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB1 (see all 7)
    OriGene shRNA RFP: KCNAB1
    OriGene siRNA: KCNAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): KCNAB1 (NM_172160)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNAB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB1

    Additional cDNA sequence: 

    AK057059.1 AK127240.1 AK292693.1 AK292999.1 AK296728.1 AK303287.1 AY780786.1 BC043166.2 
    L39833.1 L47665.1 U16953.1 U17968.1 U33428.1 

    9 DOTS entries:

    DT.414830  DT.100678459  DT.100743432  DT.95160478  DT.70105431  DT.97819777  DT.120847313  DT.91867056 
    DT.95251606 

    17 AceView cDNA sequences:

    AI344124 AA101811 AI225105 AW026476 AV690748 AI421570 AI361306 AA307631 
    CA433063 BG927156 BU071950 CD695905 AI991486 BX106158 AA101809 BF696512 
    AV700268 

    GeneLoc Exon Structure


    Expression
    for KCNAB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNAB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNAB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNAB1

    SOURCE GeneReport for Unigene cluster: Hs.654519

    UniProtKB/Swiss-Prot: KCAB1_HUMAN, Q14722
    Tissue specificity: In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant
    expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic
    heart. Up to four times more abundant in left ventricle than left atrium

        SABiosciences Expression via Pathway-Focused PCR Arrays including KCNAB1: 
              Neuronal Ion Channels in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNAB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB1

    Orthologs
    for KCNAB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for KCNAB1 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcnab11 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 92.52(n)1
    99.75(a)1    		   3 (30.15 cM)5
    164971  NM_010597.31  NP_034727.31 
     651093845 
    chicken
    (Gallus gallus)    		 Aves KCNAB11 potassium voltage-gated channel, shaker-related subfamily, more 82.71(n)
    95.26(a)    		   395730  NM_204906.1  NP_990237.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNAB16
    		 --
    		 95(a)
    		 1 ↔ 1
    		 3(15508198-15552409)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.45072 Transcribed sequence with strong similarity to protein more 78.83(n)    BX709831.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kcnab11 potassium voltage-gated channel, shaker-related subfamily, more 78.06(n)
    88.94(a)    		   541540  NM_001014354.1  NP_001014376.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hk1 , 3 potassium ion transport voltage-gated
    potassium more3
    Hyperkinetic1    		 46(a)3
    53.96(n)1
    50.3(a)1    		   1 9B53
    319551  NM_167222.21  NP_727405.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons KAB11 potassium channel beta subunit 1 52.29(n)
    48.62(a)    		   839450  NM_100349.3  NP_171963.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g08175001 hypothetical protein 53.52(n)
    50.76(a)    		   4331148  NM_001055056.1  NP_001048521.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gpr6
    ydjG6
    		 L-glyceraldehyde 3-phosphate reductase
    alpha-Keto reductase, NADH-dependent; can use meth...
    		 28(a)
    25(a)
    		 possible ortholog
    possible ortholog
    		 Chromosome(3145919-3146959)
    Chromosome(1853015-1853995)


    ENSEMBL Gene Tree for KCNAB1 (if available)
    TreeFam Gene Tree for KCNAB1 (if available) 

    Paralogs
    for KCNAB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNAB1 gene
    AKR7A32  KCNAB32  AKR7A22  KCNAB22  
    2 SIMAP similar genes for KCNAB1 using alignment to 8 protein entries:     KCAB1_HUMAN (see all proteins):
    KCNAB2    KCNAB3

    KCNAB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KCNAB1
    PGOHUM00000244583


    Genomic Variants
    for KCNAB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7050 NCBI SNPs in KCNAB1 are shown (see all 7050)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs349113651,2
    		C--153650985(+) AAAAA-/AGCAGT 1 -- ut310--------
    rs67753881,2
    		C,F,A,H,--155836353(+) TTATCT/GCTATT 1 -- us2k1 tfbs310Minor allele frequency- G:0.12NS EA NA WA 642
    rs1858736321,2
    		--155836392(+) GGAGTG/TAAGAA 1 -- us2k10--------
    rs67869041,2
    		C,F,A,H,--155836414(+) atcacA/Cgcact 1 -- us2k120Minor allele frequency- C:0.13NS EA NA WA 2160
    rs1164241221,2
    		F,--155836449(+) AACCCA/CAGCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs730266701,2
    		C,F,--155836483(+) AAACAC/GAACAG 1 -- us2k13Minor allele frequency- G:0.10WA CSA 122
    rs1454701391,2
    		--155836521(+) CCTCTC/GTCTCT 1 -- us2k10--------
    rs1890327931,2
    		--155836530(+) CTTTGA/GCTGAA 1 -- us2k10--------
    rs1922908841,2
    		--155836544(+) GCATAA/GTGCCC 1 -- us2k10--------
    rs1840767421,2
    		--155836577(+) CCCCCA/CATTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNAB1 (155755490 - 156005490 bp, first 250kb of KCNAB1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for KCNAB1
         9 CNVs: 79975 98497 63626 4358 91654 44089 91653 6218 79974
         1 Indel: 91655

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNAB1

    Disorders / Diseases
    for KCNAB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNAB1 for disorders           About GeneDecksing

    OMIM gene information: 601141    OMIM disorders: --

    11 diseases for KCNAB1:    About MalaCards
    episodic ataxia    neuronitis    epilepsy syndrome    huntington's disease
    ataxia    seizures    retinitis    tuberculosis
    malaria    alcoholism    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for KCNAB1:
    Episodic ataxia
    Human Genome Epidemiology (HuGE) Navigator: KCNAB1 (4 documents)

    Export disorders for KCNAB1 gene to outside databases

    Publications
    for KCNAB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNAB1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with KCNAB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. (PubMed id 7499366)1, 2, 3 England S.K.... Tamkun M.M. (1995)
    2. Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). (PubMed id 8938711)1, 2, 9 Leicher T.... Pongs O. (1996)
    3. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PubMed id 7649300)1, 2, 9 Mccormack K.... Stuehmer W. (1995)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. (PubMed id 8838324)1, 3 Schultz D....McCormack K. (1996)
    7. Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. (PubMed id 7890032)1, 2 Majumder K.... Wible B.A. (1995)
    8. Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. (PubMed id 7603988)1, 2 England S.K....Tamkun M.M. (1995)
    9. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. (PubMed id 7890764)1, 2 Morales M.J....Strauss H.C. (1995)
    10. Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. (PubMed id 9857044)1, 9 Leicher T.... Pongs O. (1998)

    External Searches for KCNAB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNAB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7881 HGNC: 6228 AceView: KCNAB1.1 Ensembl:ENSG00000169282 euGenes: HUgn7881
    ECgene: KCNAB1 H-InvDB: KCNAB1

    Other Databases showing KCNAB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNAB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNAB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNAB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNAB1 gene:
    Search GeneIP for patents involving KCNAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KCNAB1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for KCNAB1   OriGene shRNA RFP for KCNAB1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNAB1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNAB1  
     OriGene Protein Over-expression Lysate for KCNAB1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KCNAB1   OriGene 3'-UTR Clone for KCNAB1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNAB1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for KCNAB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNAB1   OriGene Custom Protein Services for KCNAB1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNAB1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNAB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNAB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNAB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNAB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNAB1
     GenScript Custom Purified and Recombinant Proteins Services for KCNAB1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNAB1
     GenScript Custom Assay Services for KCNAB1 GenScript Custom Superior Antibodies Services for KCNAB1
     GenScript Custom overexpressing Cell Line Services for KCNAB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNAB1 promoter
     Search Chromatin IP Primers for KCNAB1
     RT2 qPCR Primer Assay in human, mouse, rat KCNAB1
     Search GNC Networks for KCNAB1
     SABiosciences PCR Arrays including human, mouse, rat KCNAB1
     Tocris compounds for KCNAB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNAB1 antibodies
     KCNAB1 proteins
     KCNAB1 lysates
     Search for Antibodies for KCNAB1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KCNAB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for KCNAB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNAB1
     SwitchGear 3'UTR luciferase reporter plasmids for KCNAB1
     SwitchGear Promoter luciferase reporter plasmids for KCNAB1
     Search ThermoFisher Antibodies for KCNAB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNAB1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KCNAB1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4