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KCNA7 Gene

protein-coding   GIFtS: 55
GCID: GC19M049570

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 71 2     Potassium Voltage-Gated Channel Subfamily A Member 72
Voltage-Gated Potassium Channel Subunit Kv1.72 3     Voltage-Dependent Potassium Channel Kv1.72
HAK62     Voltage-Gated Potassium Channel KCNA72
KV1.72     

External Ids:    HGNC: 62261   Entrez Gene: 37432   Ensembl: ENSG000001048487   OMIM: 1762685   UniProtKB: Q96RP83   

Export aliases for KCNA7 gene to outside databases

Previous GC identifers: GC19M050228 GC19M049938 GC19M054246 GC19M054262 GC19M045947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNA7 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and
kidney. It is a candidate gene for inherited cardiac disorders. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA7 Gene:
KCNA7 (potassium voltage-gated channel, shaker-related subfamily, member 7) is a protein-coding gene. Diseases associated with KCNA7 include neuronitis, and pancreatitis. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient (By similarity)

summary for KCNA7 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNA7 gene promoter:
         p53   NF-YA   Evi-1   NF-YB   CBF-A   CBF-B   SREBP-1a   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA7 promoter sequence
   Search Chromatin IP Primers for KCNA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

KCNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049570:  view genomic region     (about GC identifiers)

Start:
49,570,675 bp from pter      End:
49,576,198 bp from pter
Size:
5,524 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 7  
Size: 456 amino acids; 50559 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Secondary accessions: A1KYX7 Q9BYS4

Explore the universe of human proteins at neXtProt for KCNA7: NX_Q96RP8

Explore proteomics data for KCNA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn191

  • See KCNA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114092.2  
    ENSEMBL proteins: 
     ENSP00000221444  
    Reactome Protein details: Q96RP8

    KCNA7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.7
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1
     IPR027359 Channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q96RP8

    ProtoNet protein and cluster: Q96RP8

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature


    UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments (By similarity)
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position (By similarity)
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily


    KCNA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA7_HUMAN, Q96RP8
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient (By similarity)

         Genatlas biochemistry entry for KCNA7:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 7 (mouse Kv1.7 homolog),expressed in
    heart,skeletal muscle and pancreatic islet cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
         
    KCNA7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNA7:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Kcna7 (no phenotypes)

    KCNA7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcna7tm1Lex for KCNA7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNA7
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    Selected qRT-PCR Assays for microRNAs that regulate KCNA7 (see all 15):
    hsa-miR-365 hsa-miR-140-3p hsa-miR-3152-3p hsa-miR-3606 hsa-miR-1294 hsa-miR-27a hsa-miR-513a-5p hsa-miR-1245
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNA7_HUMAN, Q96RP8: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----

    KCNA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNA7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNA7
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNA7
        Voltage gated Potassium channels



    KCNA7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNA7
    Interactions:

        Search GeneGlobe Interaction Network for KCNA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNA7 (ENSP000002214444) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    KCNA5ENSP000002523214STRING: ENSP00000252321
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNA7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    5 IUPHAR Ligands for KCNA7 (Kv1.7)    About this table
    LigandTypeActionAffinityPubmed IDs
    flecainide
    Pore BlockerNone5.111896454
    quinidine
    Pore BlockerNone4.811896454
    verapamil
    Pore BlockerNone4.811896454
    amiodarone
    Pore BlockerNone4.511896454
    tetraethylammonium
    Pore BlockerNone4.111896454



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNA7 gene: 
    NM_031886.2  

    Unigene Cluster for KCNA7:

    Potassium voltage-gated channel, shaker-related subfamily, member 7
    Hs.306973  [show with all ESTs]
    Unigene Representative Sequence: AJ310479
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221444(uc002pmg.3)
    miRNA
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    Additional mRNA sequence: 

    AF315818.1 AJ310479.1 AY779768.1 BC140906.1 

    1 DOTS entry:

    DT.95328255 

    10 AceView cDNA sequences:

    NM_031886 AJ310479 AF315818 F28776 F35673 F21796 AA194760 BF325690 
    AA193007 BF840283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCATCAG
    KCNA7 Expression
    About this image

    KCNA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306973

    UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
    Tissue specificity: Highly expressed in skeletal muscle, heart and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNA7 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna71 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 86.35(n)1
    93.44(a)1
      7 (29.30 cM)5
    164951  NM_010596.21  NP_034726.21 
     454059605 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA76
    potassium voltage-gated channel, shaker-related su...
    64(a)
    1 ↔ 1
    6(80043529-80071140)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel
    64(a)     --


    ENSEMBL Gene Tree for KCNA7 (if available)
    TreeFam Gene Tree for KCNA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNA7 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCNA32  KCND32  KCNA102  
    Selected SIMAP similar genes for KCNA7 using alignment to 2 protein entries:     KCNA7_HUMAN (see all proteins) (see all similar genes):
    KCNA1    KCNA4    KCNA10    KCNA2    KCNA3    KCNA5
    KCNA6    KCNS1    KCND3    KCNB1    KCNB2    KCND1
    KCNS2    KCND2    KCNC2    KCNC1    KCNC4    KCNG3

    KCNA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNA7 (see all 198)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713527291,2
    C--49570226(+) CTTGCC/TCTTGG 1 -- ds50013Minor allele frequency- T:0.07NA 124
    rs1929010571,2
    --49570581(+) CTTCCC/TACTGG 1 -- ds50010--------
    rs1847952071,2
    --49570602(+) GAAGAC/TTTATT 1 -- ds50010--------
    rs48025461,2
    C,F,A,H--49570686(+) ATTAAC/TCCAAG 1 -- ut3123Minor allele frequency- T:0.17NA NS EA WA CSA 2486
    rs1880930581,2
    --49570878(+) GGACCC/TGTGTG 1 -- ut310--------
    rs1399589031,2
    --49570901(+) GATGGA/GGACAT 1 -- ut310--------
    rs454832921,2
    C,F--49570932(+) GCCTGG/ACCCCT 1 -- ut311Minor allele frequency- A:0.09EA 120
    rs172067841,2
    C,F,H--49571113(+) TACATC/TACTCT 1 -- ut3128Minor allele frequency- T:0.35NA EA NS CSA WA 2980
    rs1809444991,2
    --49571139(+) CAACTG/TTTTCT 1 -- ut310--------
    rs1134342701,2
    C--49571148(+) TGGCT-/TTTTC 
            
    TTTTC
    1 -- ut311Minor allele frequency- TTTTC:0.50CSA 2

    HapMap Linkage Disequilibrium report for KCNA7 (49570675 - 49576198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KCNA7 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912256CNV Loss21882294
    nsv912255CNV Loss21882294
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    nsv912254CNV Loss21882294
    nsv912257CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176268    OMIM disorders: --

    2 diseases for KCNA7:    About MalaCards
    neuronitis    pancreatitis


    KCNA7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNA7
    Human Genome Epidemiology (HuGE) Navigator: KCNA7 (1 document)

    Export disorders for KCNA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNA7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCNA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. (PubMed id 11368907)1, 2, 9 Kashuba V.I.... Zabarovsky E.R. (Gene 2001)
    2. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). (PubMed id 11896454)1, 2, 9 Bardien-Kruger S....Corfield V. (Eur. J. Hum. Genet. 2002)
    3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    4. [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]. (PubMed id 15639836)1, 4 Ding Q....Guo L. (Yi Chuan 2003)
    5. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. (PubMed id 9488722)1, 9 Kalman K....Chandy K.G. (J. Biol. Chem. 1998)
    6. Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. (PubMed id 22438204)1 Finol-Urdaneta R.K....Terlau H. (EMBO Mol Med 2012)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3743 HGNC: 6226 AceView: KCNA7 Ensembl:ENSG00000104848 euGenes: HUgn3743
    ECgene: KCNA7 H-InvDB: KCNA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNA7 gene:
    Search GeneIP for patents involving KCNA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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