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KCNA7 Gene

protein-coding   GIFtS: 56

GC19M054262
potassium voltage-gated channel, shaker-related subfamily, member 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
HAK6 1, 2
KV1.7 2
Kv1.7 1
Descriptions
Voltage-gated potassium channel subunit Kv1.7 3
potassium voltage-gated channel, shaker-related subfamily,
member 7 2
voltage-dependent potassium channel Kv1.7 2
voltage-gated potassium channel KCNA7 2
External Ids
HGNC: 62261
Entrez Gene: 37432
UniProtKB: Q96RP83
Ensembl: ENSG000001048487
Search outside databases for aliases for KCNA7 gene

Previous GC identifers: GC19M050228 GC19M049938 GC19M054246

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNA7:
Potassium channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter
release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport,
smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes -
shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have
human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type
repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and
kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.
Assuming opened or closed conformations in response to the voltage difference across the membrane,
the protein forms a potassium-selective channel through which potassium ions may pass in
accordance with their electrochemical gradient (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNA7 gene  

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

KCNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054262:     (about GC identifiers)

Start:
54,262,487 bp from pter
End:
54,268,010 bp from pter
Size:
5,524 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 7  
Size: 456 amino acids; 50559 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A1KYX7 Q9BYS4

REFSEQ proteins: NP_114092.2  

ENSEMBL proteins: 
ENSP00000221444 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Millipore Purified and/or Recombinant KCNA7 Protein
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (KCNA7)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008076 voltage-gated potassium channel complex IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for KCNA7: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of KCNA7
Sigma-Aldrich Antibodies for KCNA7
Browse R&D Systems for Antibodies
Antibodies from Abcam (KCNA7), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KCNA7

Assays for KCNA7: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR005821 Ion_trans
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003972 K_chnl_volt-dep_Kv1
 IPR003968 K_chnl_volt-dep_Kv


   GeneDecks  KCNA7 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q96RP8

ProtoNet protein and cluster: Q96RP8

3 Blocks protein families:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003972 Skaker voltage-gated K+ channel family signature


UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
Domain: The N-terminus may be important in determining the rate of inactivation of the channel
while the tail may play a role in modulation of channel activity and/or targeting of the channel
to specific subcellular compartments (By similarity)
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of
positively charged amino acids at every third position (By similarity)
Similarity: Belongs to the potassium channel family. A (Shaker) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNA7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNA7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031886

              Applied Biosystems Silencer® siRNAs for KCNA7

              Sigma-Aldrich siRNA and siRNA Panels for KCNA7  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Millipore Clones for the Expression of KCNA7
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031886
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_031886
                                 untagged cDNA clone in CMV expression vector: NM_031886 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_031886

UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.
Assuming opened or closed conformations in response to the voltage difference across the membrane,
the protein forms a potassium-selective channel through which potassium ions may pass in
accordance with their electrochemical gradient (By similarity)

Genatlas biochemistry entry for KCNA7:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 7 (mouse Kv1.7
homolog),expressed in heart,skeletal muscle and pancreatic islet cells
1 MGI phenotypic allele for Kcna7 (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity IEA--
GO:0005515 protein binding IEA--
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for KCNA7
  outward current

   GeneDecks  KCNA7 for the pathways selected above  
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1 Interacting protein for KCNA7 (ENSP000002214443) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
KCNH2ENSP000002621863STRING (score=.705)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCNA7 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNA7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNA7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031886

              Sigma-Aldrich siRNA and siRNA Panels for KCNA7  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_031886  

REFSEQ mRNAs for KCNA7 gene: 

NM_031886.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_031886  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031886
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_031886
                                 untagged cDNA clone in CMV expression vector: NM_031886 

Additional cDNA sequence: 

AF315818.1 AJ310479.1 AY779768.1 BC140906.1 

1 DOTS entry:

DT.95328255 

10 AceView cDNA sequences:

NM_031886 AF315818 AJ310479 F35673 F28776 F21796 AA194760 BF325690 
AA193007 BF840283 

highest scoring ESTs for KCNA7:

AF315818 AJ310479 AA193007 BF325690 F21796 NM_031886 AA194760 AA194761 AY779768 F28776 

Unigene Cluster for KCNA7:

Potassium voltage-gated channel, shaker-related subfamily, member 7
Hs.306973  [show with all ESTs]
Unigene Representative Sequence: AJ310479


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000221444  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNA7 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCNA7

1 / 2 / 3

2 probe-sets matching KCNA7 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

232936_at2, 3 U133-B 1 1.00 1.00 -- -- AJ310479 0.80 1.00 0.91 1

232936_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCCCCATCAG

SOURCE GeneReport for Unigene cluster: Hs.306973

UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8
Tissue specificity: Highly expressed in skeletal muscle, heart and kidney

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCNA7 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNA71   -- potassium voltage-gated channel, shaker-related subfamily, more 90.57(n)
94.3(a)
484389  XM_541504.2  XP_541504.1 
cow
(Bos taurus)
KCNA71   -- potassium voltage-gated channel, shaker-related subfamily, more 88.96(n)
92.76(a)
540492  XM_611706.3  XP_611706.1 
rat
(Rattus norvegicus)
Kcna71   -- potassium voltage-gated channel, shaker-related subfamily, more 86.7(n)
93.64(a)
365241  XM_344889.2  XP_344890.1 
mouse
(Mus musculus)
Kcna71, 5 7 (23.00 cM)5
potassium voltage-gated channel, shaker-related subfamily, more1, 5 86.92(n)1
94.08(a)1
164951  NM_010596.21  NP_034726.21 
 AA0217115  AF0320995  (see all 12)
zebrafish
(Danio rerio)
LOC5724811   -- similar to Potassium voltage-gated channel subfamily more 66.08(n)
66.83(a)
572481  XM_696202.3  XP_701294.3 
About this table        Species with no ortholog for KCNA7

ENSEMBL Gene Tree for KCNA7
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCNA7 gene
KCND22  KCND12  KCND32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/51 NCBI SNPs in KCNA7 are shown (see all 51 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 23)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10172191,2
A,C,F,H,O54265250(+) GCTGCG/ATGTCC 1 T/M mis1 ese314Minor allele frequency- A:0.44MN EU EA WA NA 1222
rs116730031,2
A,C,F,H54263769(+) aggtcA/Gttgtc 1 -- ut314Minor allele frequency- G:0.14EU EA WA 416
rs48025461,2
A,C,F,H54262498(+) ATTAAC/TCCAAG 1 -- ut317Minor allele frequency- T:0.13NA EU EA WA 556
rs110839591,2
A,C,F,H54265018(+) CGTTAC/TGACTT 1 -- ut318Minor allele frequency- T:0.22EU EA WA 840
rs16117751,2
A,C,F,H54265937(-) CGCTCC/GGCTGA 1 P/R mis1 ese311Minor allele frequency- G:0.34MN EU EA WA NA 1204
rs81040831,2
A,C,F,H54268758(+) GGACTT/CAGGGT 1 -- ng314Minor allele frequency- C:0.03EU EA WA 412
rs48025471,2
C,F,H54264359(+) ATGACC/TCAACT 1 -- ut31 ese311Minor allele frequency- T:0.13NA EU EA WA 982
rs38101851,2
C,F,H54264641(+) CTCAAC/TGAAAC 1 -- ut317Minor allele frequency- T:0.05NA EU EA WA 562
rs38101861,2
C,F,H54264824(+) TGATAC/TGACCA 1 -- ut31 ese37Minor allele frequency- T:0.13NA EU EA WA 562
rs172067841,2
C,F,H54262925(+) TACATC/TACTCT 1 -- ut3116Minor allele frequency- T:0.35NA EA EU WA 1476
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HapMap Linkage Disequilibrium images for KCNA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176268

Genetic Association Database: KCNA7
Human Genome Epidemiology Navigator: KCNA7 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for KCNA7 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3743 HGNC: 6226 AceView: KCNA7 Ensembl:ENSG00000104848 euGenes: HUgn3743
ECgene: KCNA7 H-InvDB: KCNA7
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCNA7:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for KCNA7-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for KCNA7 Antibodies for KCNA7
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCNA7 Browse small molecules at Sigma-Aldrich
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for KCNA7

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