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Aliases & Descriptions for KCNA7
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HAK6 1, 2 | | KV1.7 2 | | Kv1.7 1 |
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv1.7 3 | potassium voltage-gated channel, shaker-related subfamily, member 7 2 | | voltage-dependent potassium channel Kv1.7 2 | | voltage-gated potassium channel KCNA7 2 |
|
| | Search outside databases for aliases for KCNA7 genePrevious GC identifers: GC19M050228 GC19M049938 GC19M054246 |
Summaries for KCNA7(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNA7: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity) |
Genomic Location for KCNA7
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNA7 gene 
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3KCNA7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M054262:
(about GC identifiers)
Start:
|
54,262,487 bp from pter |
End:
|
54,268,010 bp from pter |
Size:
|
5,524 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for KCNA7
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily A member 7 Size: 456 amino acids; 50559 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A1KYX7 Q9BYS4REFSEQ proteins: NP_114092.2
ENSEMBL proteins: ENSP00000221444
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for KCNA7: Assays for KCNA7: | Protein
Domains/ Families for KCNA7(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96RP8
ProtoNet protein and cluster: Q96RP8 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003972 Skaker voltage-gated K+ channel family signature
UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments (By similarity)Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)Similarity: Belongs to the potassium channel family. A (Shaker) subfamily | Gene Function for KCNA7
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031886
Applied Biosystems Silencer® siRNAs for KCNA7
Sigma-Aldrich siRNA and siRNA Panels for KCNA7  Sigma-Aldrich shRNA Panels and shRNA for KCNA7  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031886                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031886                                  untagged cDNA clone in CMV expression vector: NM_031886 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_031886
UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity)Genatlas biochemistry entry for KCNA7:potassium voltage-gated channel,Drosophila shaker-related subfamily,member 7 (mouse Kv1.7 homolog),expressed in heart,skeletal muscle and pancreatic islet cells1 MGI phenotypic allele for Kcna7 (no phenotypes)
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNA7
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for KCNA7 (ENSP000002214443) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
IEA | -- | About this table
|
Drugs & Compounds for KCNA7(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNA7 available from Tocris Bioscience About this table
|
Transcripts for KCNA7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031886
Sigma-Aldrich siRNA and siRNA Panels for KCNA7  Sigma-Aldrich shRNA Panels and shRNA for KCNA7  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_031886 REFSEQ mRNAs for KCNA7 gene: NM_031886.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_031886               OriGene GFP tagged cDNA clone in CMV expression vector: NM_031886                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031886                                  untagged cDNA clone in CMV expression vector: NM_031886  Additional cDNA sequence: AF315818.1 AJ310479.1 AY779768.1 BC140906.1 1 DOTS entry: DT.95328255 10 AceView cDNA sequences:NM_031886 AF315818 AJ310479 F35673 F28776 F21796 AA194760 BF325690 AA193007 BF840283
highest scoring ESTs for KCNA7:AF315818 AJ310479 AA193007 BF325690 F21796 NM_031886 AA194760 AA194761 AY779768 F28776 Unigene Cluster for KCNA7: Potassium voltage-gated channel, shaker-related subfamily, member 7 Hs.306973 [show with all ESTs]Unigene Representative Sequence: AJ310479
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000221444
|
Expression for KCNA7
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNA7 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNA7
1 / 2 / 3 2 probe-sets matching KCNA7 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCCCCATCAG
SOURCE GeneReport for Unigene cluster: Hs.306973 UniProtKB/Swiss-Prot: KCNA7_HUMAN, Q96RP8Tissue specificity: Highly expressed in skeletal muscle, heart and kidney |
Orthologs for KCNA7
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNA7 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNA71 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
90.57(n) 94.3(a) |
484389 XM_541504.2 XP_541504.1 |
cow (Bos taurus) |
KCNA71 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
88.96(n) 92.76(a) |
540492 XM_611706.3 XP_611706.1 |
rat (Rattus norvegicus) |
Kcna71 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
86.7(n) 93.64(a) |
365241 XM_344889.2 XP_344890.1 |
mouse (Mus musculus) |
Kcna71, 5 |
7 (23.00 cM)5
|
potassium voltage-gated channel, shaker-related subfamily, more1, 5 |
86.92(n)1 94.08(a)1 |
164951 NM_010596.21 NP_034726.21 AA0217115 AF0320995 (see all 12) |
zebrafish (Danio rerio) |
LOC5724811 |
-- |
similar to Potassium voltage-gated channel subfamily more |
66.08(n) 66.83(a) |
572481 XM_696202.3 XP_701294.3 |
About this table Species with no ortholog for KCNA7
ENSEMBL Gene Tree for KCNA7 | Paralogs for KCNA7(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNA7 gene
- KCND22 KCND12 KCND32
|
SNPs/Variants for KCNA7(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNA7 (up to first 250kb)
|
Disorders & Mutations for KCNA7
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 176268
Genetic Association Database: KCNA7 Human Genome Epidemiology Navigator: KCNA7 (1 document)
|
Medical News for KCNA7(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNA7 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for KCNA7 gene:- Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. (PubMed id 11368907)1, 3, 4 Kashuba V.I.... Zabarovsky E.R. (2001)
- Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). (PubMed id 11896454)1, 3, 4 Bardien-Kruger S....Corfield V. (2002)
- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)2, 3 Gutman G.A....Wang X. (2005)
- [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China] (PubMed id 15639836)3, 6 Ding Q....Guo L. (2003)
- Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. (PubMed id 9488722)1, 3 Kalman K....Chandy K.G. (1998)
|
Search for KCNA7
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNA7
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNA7
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNA7(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNA7(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNA7:

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| | | | Tocris compounds for KCNA7 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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