Aliases for KCNA7 Gene
- Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 7 2 3
- Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 7 2 3
- Voltage-Gated Potassium Channel Subunit Kv1.7 3 4
- Potassium Voltage-Gated Channel Subfamily A Member 7 3
- Voltage-Dependent Potassium Channel Kv1.7 3
- Voltage-Gated Potassium Channel KCNA7 3
- KV1.7 3
- HAK6 3
External Ids for KCNA7 Gene
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNA7 Gene
KCNA7 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 7) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.
UniProtKB/Swiss-Prot for KCNA7 Gene
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.