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Aliases for KCNA6 Gene

Aliases for KCNA6 Gene

  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 6 2 3
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 6 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.6 3 4
  • Voltage-Gated Potassium Channel HBK2 3 4
  • Potassium Voltage-Gated Channel Subfamily A Member 6 3
  • Voltage-Gated Potassium Channel Protein Kv1.6 3
  • Protein Phosphatase 1, Regulatory Subunit 96 3
  • Human Brain Potassium Channel-2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 96 2
  • PPP1R96 3
  • KV1.6 3
  • HBK2 3

External Ids for KCNA6 Gene

Summaries for KCNA6 Gene

Entrez Gene Summary for KCNA6 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA6 Gene

KCNA6 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 6) is a Protein Coding gene. Diseases associated with KCNA6 include benign neonatal seizures. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include voltage-gated potassium channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA6 Gene

  • Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).

Tocris Summary for KCNA6 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA6 Gene

Genomics for KCNA6 Gene

Genomic Location for KCNA6 Gene

Start:
4,809,176 bp from pter
End:
4,851,927 bp from pter
Size:
42,752 bases
Orientation:
Plus strand

Genomic View for KCNA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA6 Gene

Regulatory Elements for KCNA6 Gene

Proteins for KCNA6 Gene

  • Protein details for KCNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17658-KCNA6_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 6
    Protein Accession:
    P17658
    Secondary Accessions:

    Protein attributes for KCNA6 Gene

    Size:
    529 amino acids
    Molecular mass:
    58729 Da
    Quaternary structure:
    • Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity).

neXtProt entry for KCNA6 Gene

Proteomics data for KCNA6 Gene at MOPED

Post-translational modifications for KCNA6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn46

Other Protein References for KCNA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA6 Gene

Domains for KCNA6 Gene

Gene Families for KCNA6 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNA6_HUMAN
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments:
    • P17658
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.:
    • P17658
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.:
    • P17658
genes like me logo Genes that share domains with KCNA6: view

Function for KCNA6 Gene

Molecular function for KCNA6 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila shaker-related subfamily,member 6 (mouse Kv1.6 homolog)
UniProtKB/Swiss-Prot Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).

Gene Ontology (GO) - Molecular Function for KCNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity TAS 2347305
GO:0005251 delayed rectifier potassium channel activity IDA 2347305
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNA6: view
genes like me logo Genes that share phenotypes with KCNA6: view

Animal Models for KCNA6 Gene

MGI Knock Outs for KCNA6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNA6 Gene

Localization for KCNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA6 Gene COMPARTMENTS Subcellular localization image for KCNA6 gene
Compartment Confidence
plasma membrane 4
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0008076 voltage-gated potassium channel complex ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNA6: view

Pathways for KCNA6 Gene

genes like me logo Genes that share pathways with KCNA6: view

Pathways by source for KCNA6 Gene

1 Qiagen pathway for KCNA6 Gene

Gene Ontology (GO) - Biological Process for KCNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 2347305
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNA6: view

Compounds for KCNA6 Gene

(5) Tocris Compounds for KCNA6 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(4) IUPHAR Ligand for KCNA6 Gene

Ligand Type Action Affinity Pubmed IDs
mast cell degranulating peptide Pore Blocker None 8
charybdotoxin Inhibitor None
alpha-dendrotoxin Inhibitor None
tetraethylammonium Inhibitor None

(1) Novoseek inferred chemical compound relationships for KCNA6 Gene

Compound -log(P) Hits PubMed IDs
potassium 46.7 1
genes like me logo Genes that share compounds with KCNA6: view

Transcripts for KCNA6 Gene

mRNA/cDNA for KCNA6 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA6 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA6 Gene

No ASD Table

Relevant External Links for KCNA6 Gene

GeneLoc Exon Structure for
KCNA6
ECgene alternative splicing isoforms for
KCNA6

Expression for KCNA6 Gene

mRNA expression in normal human tissues for KCNA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNA6 Gene

SOURCE GeneReport for Unigene cluster for KCNA6 Gene Hs.306190

genes like me logo Genes that share expressions with KCNA6: view

Orthologs for KCNA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA6 36
  • 99.05 (n)
  • 99.24 (a)
KCNA6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNA6 36
  • 90.7 (n)
  • 95.64 (a)
KCNA6 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA6 36
  • 92.62 (n)
  • 95.93 (a)
KCNA6 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna6 36
  • 86.43 (n)
  • 92.99 (a)
Kcna6 16
Kcna6 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNA6 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA6 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcna6 36
  • 86.45 (n)
  • 92.82 (a)
chicken
(Gallus gallus)
Aves LOC100858067 36
  • 74.02 (n)
  • 78.31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492986 36
  • 68.71 (n)
  • 78 (a)
zebrafish
(Danio rerio)
Actinopterygii kcna6 37
  • 63 (a)
OneToMany
KCNA6 (2 of 2) 37
  • 73 (a)
OneToMany
LOC100536252 36
  • 74.1 (n)
  • 78.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sh 38
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 38
  • 31 (a)
Species with no ortholog for KCNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA6 Gene

ENSEMBL:
Gene Tree for KCNA6 (if available)
TreeFam:
Gene Tree for KCNA6 (if available)

Paralogs for KCNA6 Gene

Selected SIMAP similar genes for KCNA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA6: view

Variants for KCNA6 Gene

Sequence variations from dbSNP and Humsavar for KCNA6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3319 -- 4,812,864(+) TGGAG(C/G)TGCAT utr-variant-3-prime
rs12336 -- 4,850,951(+) AATGT(C/T)GGGGT utr-variant-3-prime
rs14054 -- 4,850,857(+) TCTGG(A/C/G)CTGAC utr-variant-3-prime
rs700480 -- 4,850,923(+) ACCCG(C/T)TGTCC utr-variant-3-prime
rs758533 -- 4,809,744(+) AGCCA(A/G)TTTCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNA6 Gene

Variant ID Type Subtype PubMed ID
nsv819008 CNV Loss 19587683
nsv520570 CNV Loss 19592680

Relevant External Links for KCNA6 Gene

HapMap Linkage Disequilibrium report
KCNA6

Disorders for KCNA6 Gene

(1) MalaCards Diseases for KCNA6 Gene

Search for KCNA6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KCNA6 Gene

Relevant External Links for KCNA6

Genetic Association Database (GAD)
KCNA6
Human Genome Epidemiology (HuGE) Navigator
KCNA6
genes like me logo Genes that share disorders with KCNA6: view

No data available for UniProtKB/Swiss-Prot for KCNA6 Gene

Publications for KCNA6 Gene

  1. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. (PMID: 8821794) Albrecht B. … Pongs O. (Recept. Channels 1995) 3 23
  2. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. (PMID: 2347305) Grupe A. … Pongs O. (EMBO J. 1990) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for KCNA6 Gene

Sources for KCNA6 Gene

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