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Aliases for KCNA6 Gene

Aliases for KCNA6 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 6 2 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 6 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.6 3 4
  • Voltage-Gated Potassium Channel HBK2 3 4
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 6 3
  • Voltage-Gated Potassium Channel Protein Kv1.6 3
  • Protein Phosphatase 1, Regulatory Subunit 96 3
  • Human Brain Potassium Channel-2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 96 2
  • PPP1R96 3
  • KV1.6 3
  • HBK2 3

External Ids for KCNA6 Gene

Previous GeneCards Identifiers for KCNA6 Gene

  • GC12P004655
  • GC12P004810
  • GC12P004788
  • GC12P004918

Summaries for KCNA6 Gene

Entrez Gene Summary for KCNA6 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA6 Gene

KCNA6 (Potassium Voltage-Gated Channel Subfamily A Member 6) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA6 Gene

  • Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).

Tocris Summary for KCNA6 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNA6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA6 Gene

Genomics for KCNA6 Gene

Regulatory Elements for KCNA6 Gene

Genomic Location for KCNA6 Gene

Chromosome:
12
Start:
4,806,885 bp from pter
End:
4,851,114 bp from pter
Size:
44,230 bases
Orientation:
Plus strand

Genomic View for KCNA6 Gene

Genes around KCNA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA6 Gene

Proteins for KCNA6 Gene

  • Protein details for KCNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17658-KCNA6_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 6
    Protein Accession:
    P17658

    Protein attributes for KCNA6 Gene

    Size:
    529 amino acids
    Molecular mass:
    58729 Da
    Quaternary structure:
    • Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity).

neXtProt entry for KCNA6 Gene

Proteomics data for KCNA6 Gene at MOPED

Post-translational modifications for KCNA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA6 Gene

Domains & Families for KCNA6 Gene

Suggested Antigen Peptide Sequences for KCNA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17658

UniProtKB/Swiss-Prot:

KCNA6_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.
genes like me logo Genes that share domains with KCNA6: view

Function for KCNA6 Gene

Molecular function for KCNA6 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 6 (mouse Kv1.6 homolog)
UniProtKB/Swiss-Prot Function:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).
genes like me logo Genes that share phenotypes with KCNA6: view

Animal Models for KCNA6 Gene

MGI Knock Outs for KCNA6:

Animal Model Products

miRNA for KCNA6 Gene

miRTarBase miRNAs that target KCNA6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNA6 Gene

Localization for KCNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA6 Gene COMPARTMENTS Subcellular localization image for KCNA6 gene
Compartment Confidence
plasma membrane 5
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNA6: view

Pathways & Interactions for KCNA6 Gene

genes like me logo Genes that share pathways with KCNA6: view

Gene Ontology (GO) - Biological Process for KCNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with KCNA6: view

No data available for SIGNOR curated interactions for KCNA6 Gene

Drugs & Compounds for KCNA6 Gene

(7) Drugs for KCNA6 Gene - From: DGIdb, IUPHAR, Tocris, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dalfampridine Approved Pharma Pore Blocker, Target, antagonist 62
tetraethylammonium Experimental Pharma Inhibitor 1
charybdotoxin Pharma Pore Blocker, blocker 0
mast cell degranulating peptide Pharma Pore Blocker 0
Α-DENDROTOXIN Pharma 0

(5) Additional Compounds for KCNA6 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-dendrotoxin
Inhibitor
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4
genes like me logo Genes that share compounds with KCNA6: view

Transcripts for KCNA6 Gene

mRNA/cDNA for KCNA6 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA6 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA6 Gene

No ASD Table

Relevant External Links for KCNA6 Gene

GeneLoc Exon Structure for
KCNA6
ECgene alternative splicing isoforms for
KCNA6

Expression for KCNA6 Gene

mRNA expression in normal human tissues for KCNA6 Gene

Protein differential expression in normal tissues from HIPED for KCNA6 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNA6 Gene



SOURCE GeneReport for Unigene cluster for KCNA6 Gene Hs.306190

genes like me logo Genes that share expression patterns with KCNA6: view

Protein tissue co-expression partners for KCNA6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNA6 Gene

Orthologs for KCNA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA6 35
  • 99.05 (n)
  • 99.24 (a)
KCNA6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNA6 36
  • 96 (a)
OneToOne
KCNA6 35
  • 90.7 (n)
  • 95.64 (a)
dog
(Canis familiaris)
Mammalia KCNA6 35
  • 92.62 (n)
  • 95.93 (a)
KCNA6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna6 16
Kcna6 35
  • 86.43 (n)
  • 92.99 (a)
Kcna6 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNA6 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA6 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcna6 35
  • 86.45 (n)
  • 92.82 (a)
chicken
(Gallus gallus)
Aves LOC100858067 35
  • 74.02 (n)
  • 78.31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492986 35
  • 68.71 (n)
  • 78 (a)
zebrafish
(Danio rerio)
Actinopterygii kcna6 36
  • 63 (a)
OneToMany
KCNA6 (2 of 2) 36
  • 73 (a)
OneToMany
LOC100536252 35
  • 74.1 (n)
  • 78.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 37
  • 31 (a)
Species with no ortholog for KCNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA6 Gene

ENSEMBL:
Gene Tree for KCNA6 (if available)
TreeFam:
Gene Tree for KCNA6 (if available)

Paralogs for KCNA6 Gene

(14) SIMAP similar genes for KCNA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA6: view

Variants for KCNA6 Gene

Sequence variations from dbSNP and Humsavar for KCNA6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs700480 -- 4,850,923(+) ACCCG(C/T)TGTCC utr-variant-3-prime
rs758533 -- 4,809,744(+) AGCCA(A/G)TTTCA utr-variant-5-prime
rs758534 -- 4,810,101(+) GAGGG(A/G)GAGCA reference, synonymous-codon
rs2041383 -- 4,843,544(-) CTAAC(A/G)TAACT intron-variant
rs2159527 -- 4,846,055(-) TTTTG(A/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNA6 Gene

Variant ID Type Subtype PubMed ID
nsv819008 CNV Loss 19587683
nsv520570 CNV Loss 19592680

Variation tolerance for KCNA6 Gene

Residual Variation Intolerance Score: 7.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA6 Gene

HapMap Linkage Disequilibrium report
KCNA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA6 Gene

Disorders for KCNA6 Gene

Relevant External Links for KCNA6

Genetic Association Database (GAD)
KCNA6
Human Genome Epidemiology (HuGE) Navigator
KCNA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA6

No disorders were found for KCNA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNA6 Gene

Publications for KCNA6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. (PMID: 8821794) Albrecht B. … Pongs O. (Recept. Channels 1995) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KCNA6 Gene

Sources for KCNA6 Gene

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