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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA6 Gene

protein-coding   GIFtS: 62
GCID: GC12P004918

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 61 2     KV1.62
Voltage-Gated Potassium Channel HBK22 3     Human Brain Potassium Channel-22
Voltage-Gated Potassium Channel Subunit Kv1.62 3     Potassium Voltage-Gated Channel Subfamily A Member 62
HBK22     Voltage-Gated Potassium Channel Protein Kv1.62

External Ids:    HGNC: 62251   Entrez Gene: 37422   Ensembl: ENSG000001510797   OMIM: 1762575   UniProtKB: P176583   
ORGUL members:    fRNAdb10:FR230455      
H-InvDB12:HIT000014470    
NCBI13:AK057863    

Export aliases for KCNA6 gene to outside databases

Previous GC identifers: GC12P004655 GC12P004810 GC12P004788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNA6 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this
gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. (provided by RefSeq,
Jul 2008)

GeneCards Summary for KCNA6 Gene: 
KCNA6 (potassium voltage-gated channel, shaker-related subfamily, member 6) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with KCNA6 include benign neonatal seizures, and familial dyskinesia and facial myokymia, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNC2.

UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient

summary for KCNA6 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA6 Gene

fRNAdb sequence ontology for KCNA6:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for KCNA6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA6 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   E2F-2   E47   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

KCNA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P004918:  view genomic region     (about GC identifiers)

Start:
4,918,342 bp from pter      End:
4,960,278 bp from pter
Size:
41,937 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 6  
Size: 529 amino acids; 58729 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNA6: NX_P17658

Explore proteomics data for KCNA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17658

  • KCNA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNA6 Protein Expression
    REFSEQ proteins: NP_002226.1  
    ENSEMBL proteins: 
     ENSP00000280684   ENSP00000408321  
    Reactome Protein details: P17658
    Human Recombinant Protein Products for KCNA6: 
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    Cloud-Clone Corp. Proteins for KCNA6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----

    KCNA6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.6 
    Voltage-gated potassium channels

    5/9 InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR004053 K_chnl_volt-dep_Kv1.6
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P17658

    ProtoNet protein and cluster: P17658

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004053 Kv1.6 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily


    KCNA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA6_HUMAN, P17658
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient

         Genatlas biochemistry entry for KCNA6:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 6 (mouse Kv1.6 homolog)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS2347305
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
         
    KCNA6 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcna6):
     behavior/neurological  homeostasis/metabolism  integument 

    KCNA6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcna6tm1Lex for KCNA6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNA6 
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    SwitchGear 3'UTR luciferase reporter plasmidKCNA6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNA6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNA6
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA6
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNA6
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for KCNA6 (P176583 ENSP000002806844) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNAB1Q147223I2D: score=1 
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS2347305
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNA6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNA6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    4 IUPHAR Ligands for KCNA6 (Kv1.6)    About this table 
    LigandTypeActionAffinityPubmed IDs
    charybdotoxin
    Pore BlockerNone92347305
    mast cell degranulating peptide
    Pore BlockerNone82347305
    α-dendrotoxin
    Pore BlockerNone7.72347305
    tetraethylammonium
    InhibitorNone7.7--

    1 Novoseek inferred chemical compound relationship for KCNA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 46.7 2 8719753 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for KCNA6 gene: 
    NM_002235.3  

    Unigene Cluster for KCNA6:

    Potassium voltage-gated channel, shaker-related subfamily, member 6
    Hs.306190  [show with all ESTs]
    Unigene Representative Sequence: NM_002235
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280684(uc021qtr.1) ENST00000433855(uc001qng.3)
    miRNA
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    hsa-miR-345 hsa-miR-1321 hsa-miR-3607-3p hsa-let-7d hsa-miR-3921 hsa-miR-759 hsa-miR-3162-5p hsa-let-7g
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    Additional mRNA sequence: 

    AK057863.1 BC069355.1 X17622.1 

    6 DOTS entries:

    DT.100017225  DT.442806  DT.121205686  DT.121205638  DT.121205631  DT.91694726 

    24/60 AceView cDNA sequences (see all 60):

    AA242896 BM719843 CA442989 AJ505959 BC069355 NM_017417 AJ271385 CD724101 
    BM852999 BQ774134 AA609028 AI655634 AA812749 CA411999 AA083984 AA082828 
    BM984255 BX280914 N46757 AA083815 CB153065 BQ102472 AW005440 BF057823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNA6 expression in normal human tissues (normalized intensities)      KCNA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATGTTGC
    KCNA6 Expression
    About this image


    KCNA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See KCNA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNA6

    SOURCE GeneReport for Unigene cluster: Hs.306190
        SABiosciences Expression via Pathway-Focused PCR Array including KCNA6: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNA6 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna61 , 5 potassium voltage-gated channel, shaker-related, subfamily, more1, 5 86.3(n)1
    93.18(a)1
      6 (61.72 cM)5
    164941  NM_013568.61  NP_038596.11 
     1267083295 
    chicken
    (Gallus gallus)
    Aves LOC1008580671 potassium voltage-gated channel subfamily A member more 73.7(n)
    77.24(a)
      100858067  XM_003643151.1  XP_003643199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005362521 potassium voltage-gated channel subfamily A member more 74.36(n)
    78.41(a)
      100536252  XM_003201760.1  XP_003201808.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel
    66(a)     --


    ENSEMBL Gene Tree for KCNA6 (if available)
    TreeFam Gene Tree for KCNA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNA6 gene
    KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCNA32  KCND32  KCNA102  
    14 SIMAP similar genes for KCNA6 using alignment to 1 protein entry:     KCNA6_HUMAN:
    KCNA1    KCNA2    KCNA4    KCNA5    KCNA10    KCNA3
    KCNA7    KCNB2    KCND1    KCND2    KCND3    KCNS2
    KCNB1    KCNS1

    KCNA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1034 SNPs in KCNA6 are shown (see all 1034)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568150601,2
    C--4882592(+) TGTGTGTGT/-  
            
    CTGCT
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs1410143641,2
    C--4916389(+) CATGAG/TATGGG 1 -- us2k10--------
    rs1434281221,2
    --4916429(+) GTTTGC/GAGAAA 1 -- us2k10--------
    rs1444908551,2
    C--4916511(+) CCACA-/AATT  
            
    AATTA
    1 -- us2k10--------
    rs1816614361,2
    --4916633(+) CCCACA/GGGTGG 1 -- us2k10--------
    rs740561341,2
    C,F--4916725(+) TACATG/ACCCTG 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1843490331,2
    --4916830(+) ATAAGC/TTTTCA 1 -- us2k10--------
    rs1471280631,2
    --4916893(+) TGGGGA/GATCAA 1 -- us2k10--------
    rs1404252761,2
    C--4916914(+) AGGGCA/GTTGGT 1 -- us2k10--------
    rs1420970011,2
    --4916975(+) GCTCAA/GCTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNA6 (4918342 - 4960278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCNA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819008CNV Loss19587683
    nsv520570CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176257    OMIM disorders: --

    7 diseases for KCNA6:    About MalaCards
    benign neonatal seizures    familial dyskinesia and facial myokymia    myokymia    episodic ataxia
    juvenile myoclonic epilepsy    ataxia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for KCNA6:
    Benign neonatal seizures     Episodic ataxia

    KCNA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNA6
    Human Genome Epidemiology (HuGE) Navigator: KCNA6 (1 document)

    Export disorders for KCNA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNA6 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with KCNA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. (PubMed id 2347305)1, 2 Grupe A.... Pongs O. (1990)
    5. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. (PubMed id 8821794)1, 9 Albrecht B....Pongs O. (1995)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Clinical spectrum of voltage-gated potassium channel autoimmunity. (PubMed id 18474843)1 Tan K.M....Pittock S.J. (2008)
    8. The RCK2 domain of the human BKCa channel is a calcium sensor. (PubMed id 18162557)1 Yusifov T....Olcese R. (2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3742 HGNC: 6225 AceView: KCNA6andGALNT8 Ensembl:ENSG00000151079 euGenes: HUgn3742
    ECgene: KCNA6 H-InvDB: KCNA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNA6 gene:
    Search GeneIP for patents involving KCNA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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