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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA6 Gene

protein-coding   GIFtS: 61
GCID: GC12P004918

potassium voltage-gated channel, shaker-related subfamily,...
 Explore 5 diseases affiliated with
KCNA6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNA6    

Aliases
for KCNA6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 61 2     KV1.62
HBK21 2     Human Brain Potassium Channel-22
Voltage-Gated Potassium Channel HBK22 3     Potassium Voltage-Gated Channel Subfamily A Member 62
Voltage-Gated Potassium Channel Subunit Kv1.62 3     Voltage-Gated Potassium Channel Protein Kv1.62
Kv1.61     

External Ids:    HGNC: 62251   Entrez Gene: 37422   Ensembl: ENSG000001510797   OMIM: 1762575   UniProtKB: P176583   
ORGUL members:    fRNAdb10:FR230455      
H-InvDB:HIT000014470    
NCBI:AK057863    

Export aliases for KCNA6 gene to outside databases

Previous GC identifers: GC12P004655 GC12P004810 GC12P004788


Summaries
for KCNA6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNA6:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each
has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is
clustered with genes KCNA1 and KCNA5 on chromosome 12. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
channel through which potassium ions may pass in accordance with their electrochemical gradient

summary for KCNA6:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA6

fRNAdb sequence ontology for KCNA6:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for KCNA6

Genomic Views
for KCNA6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA6 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   E2F-2   E47   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

KCNA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P004918:  view genomic region     (about GC identifiers)

Start:
 4,918,342 bp from pter      End:
 4,960,278 bp from pter
Size:
 41,937 bases      Orientation:
 plus strand

Proteins
for KCNA6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 6  
Size: 529 amino acids; 58729 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNA6: NX_P17658

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17658

    • KCNA6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002226.1  
    ENSEMBL proteins: 
     ENSP00000280684   ENSP00000408321  
    Reactome Protein details: P17658
    Human Recombinant Protein Products: 
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    Uscn Proteins for KCNA6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--


    KCNA6 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for KCNA6

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    Uscn ELISAs and CLIAs for KCNA6

    Protein Domains /
    Families
    for KCNA6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNA6 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR004053 K_chnl_volt-dep_Kv1.6
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P17658

    ProtoNet protein and cluster: P17658

    4 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004053 Kv1.6 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play
    a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily


    Function
    for KCNA6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
    conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
    channel through which potassium ions may pass in accordance with their electrochemical gradient

         Genatlas biochemistry entry for KCNA6:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 6 (mouse Kv1.6 homolog)

    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA6 (see all 56):
    hsa-miR-345 hsa-miR-1321 hsa-miR-3607-3p hsa-let-7d hsa-miR-3921 hsa-miR-759 hsa-miR-3162-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: KCNA6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNA6 (see all 4)
    OriGene shRNA RFP: KCNA6
    OriGene siRNA: KCNA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KCNA6

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA6 

    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005249voltage-gated potassium channel activity TAS2347305
    GO:0005251delayed rectifier potassium channel activity IBA--


    KCNA6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Kcna6tm1Lex for KCNA6
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kcna6):
     behavior/neurological  homeostasis/metabolism  integument 

    KCNA6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNA6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNA6
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA6
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNA6
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for KCNA6 (P176583 ENSP000002806844) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNAB1Q147223I2D: score=1 
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS2347305
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--


    KCNA6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNA6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNA6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNA6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Chromanol 293BIKs blocker. Also blocks ICFTR[163163-23-3]
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    (-)-[3R,4S]-Chromanol 293B IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)[163163-24-4]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    1 Novoseek chemical compound relationship for KCNA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 46.7 2 8719753 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNA6 

    Transcripts
    for KCNA6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 1 fRNAdb Secondary structure:


    REFSEQ mRNAs for KCNA6 gene: 
    NM_002235.3  

    Unigene Cluster for KCNA6:

    Potassium voltage-gated channel, shaker-related subfamily, member 6
    Hs.306190  [show with all ESTs]
    Unigene Representative Sequence: NM_002235
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280684(uc021qtr.1) ENST00000433855(uc001qng.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KCNA6
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA6
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA6 (see all 56):
    hsa-miR-345 hsa-miR-1321 hsa-miR-3607-3p hsa-let-7d hsa-miR-3921 hsa-miR-759 hsa-miR-3162-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: KCNA6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNA6 (see all 4)
    OriGene shRNA RFP: KCNA6
    OriGene siRNA: KCNA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA6
    Clone
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    GenScript: all cDNA clones in your preferred vector: KCNA6 (NM_002235)
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    Primer
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    Additional cDNA sequence: 

    AK057863.1 BC069355.1 X17622.1 

    6 DOTS entries:

    DT.100017225  DT.442806  DT.121205686  DT.121205638  DT.121205631  DT.91694726 

    24/60 AceView cDNA sequences (see all 60):

    BQ774134 CA442989 AJ271385 BC069355 BM852999 NM_017417 AA242896 AJ505959 
    BM719843 CD724101 AA609028 BX090709 BQ128051 AK057863 AA083815 AI655634 
    T28887 N46757 AA082828 NM_002235 BM984255 CB153065 AW005440 AA083984 

    GeneLoc Exon Structure


    Expression
    for KCNA6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTATGTTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNA6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Growth PlateBone
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNA6

    SOURCE GeneReport for Unigene cluster: Hs.306190
        SABiosciences Expression via Pathway-Focused PCR Array including KCNA6: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA6

    Orthologs
    for KCNA6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNA6 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008580671 potassium voltage-gated channel subfamily A member more 73.7(n)
    77.24(a)    		   100858067  XM_003643151.1  XP_003643199.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005362521 potassium voltage-gated channel subfamily A member more 74.36(n)
    78.41(a)    		   100536252  XM_003201760.1  XP_003201808.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sh3 courtship behavior voltage-gated potassium
    channel    		 66(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55F3C.33   -- 31(a)   IV(742316-752934)   --


    ENSEMBL Gene Tree for KCNA6 (if available)
    TreeFam Gene Tree for KCNA6 (if available) 

    Paralogs
    for KCNA6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNA6 gene
    KCNA22  KCNC22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCND32  KCNA32  KCNA102  
    15 SIMAP similar genes for KCNA6 using alignment to 1 protein entry:     KCNA6_HUMAN:
    KCNA1    KCNA2    KCNA4    KCNA5    KCNA10    KCNA3
    KCNA7    KCNB2    KCND1    KCND2    KCND3    KCNS2
    KCNB1    KCNS1    KCNC2

    KCNA6 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNA6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/915 NCBI SNPs in KCNA6 are shown (see all 915)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1410143641,2
    		--4916389(+) CATGAG/TATGGG 1 -- us2k10--------
    rs1434281221,2
    		--4916429(+) GTTTGC/GAGAAA 1 -- us2k10--------
    rs1444908551,2
    		C,--4916511(+) CCACA-/AATT  
                AATTA     		1 -- us2k10--------
    rs1816614361,2
    		--4916633(+) CCCACA/GGGTGG 1 -- us2k10--------
    rs740561341,2
    		C,--4916725(+) TACATG/ACCCTG 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1843490331,2
    		--4916830(+) ATAAGC/TTTTCA 1 -- us2k10--------
    rs1471280631,2
    		--4916893(+) TGGGGA/GATCAA 1 -- us2k10--------
    rs1404252761,2
    		--4916914(+) AGGGCA/GTTGGT 1 -- us2k10--------
    rs1420970011,2
    		--4916975(+) GCTCAA/GCTGGT 1 -- us2k10--------
    rs1511633071,2
    		--4917148(+) ATACTC/TCGTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNA6 (4918342 - 4960278 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KCNA6
         1 Indel: 58570

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    Disorders / Diseases
    for KCNA6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNA6 for disorders           About GeneDecksing

    OMIM gene information: 176257    OMIM disorders: --

    5 diseases for KCNA6:    About MalaCards
    juvenile myoclonic epilepsy    myokymia    episodic ataxia    neuronitis
    ataxia

    2 diseases from the University of Copenhagen DISEASES database for KCNA6:
    Benign neonatal seizures     Episodic ataxia
    Human Genome Epidemiology (HuGE) Navigator: KCNA6 (1 document)

    Export disorders for KCNA6 gene to outside databases

    Publications
    for KCNA6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNA6 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with KCNA6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. (PubMed id 2347305)1, 2 Grupe A.... Pongs O. (1990)
    4. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. (PubMed id 8821794)1, 9 Albrecht B....Pongs O. (1995)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Clinical spectrum of voltage-gated potassium channel autoimmunity. (PubMed id 18474843)1 Tan K.M....Pittock S.J. (2008)
    7. The RCK2 domain of the human BKCa channel is a calcium sensor. (PubMed id 18162557)1 Yusifov T....Olcese R. (2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Analysis of a human brain voltage-gated potassium channel gene, KCNA6 (HBK2), in patients with juvenile myoclonic epilepsy. (PubMed id 8719753)9 Rees M....Gardiner M. (1995)

    External Searches for KCNA6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNA6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3742 HGNC: 6225 AceView: KCNA6andGALNT8 Ensembl:ENSG00000151079 euGenes: HUgn3742
    ECgene: KCNA6 H-InvDB: KCNA6

    Other Databases showing KCNA6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNA6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNA6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNA6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNA6 gene:
    Search GeneIP for patents involving KCNA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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