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Aliases & Descriptions for KCNA6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ25134 2 | | HBK2 1, 2, 3 | | KV1.6 2 | | Kv1.6 1 |
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv1.6 3 | | human brain potassium channel-2 2 | potassium voltage-gated channel, shaker-related subfamily, member 6 2 | | voltage-gated potassium channel protein Kv1.6 2 |
|
| | Search outside databases for aliases for KCNA6 genePrevious GC identifers: GC12P004655 GC12P004810 |
Summaries for KCNA6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNA6: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient |
Genomic Location for KCNA6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNA6 gene 
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13KCNA6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P004788:
(about GC identifiers)
Start:
|
4,788,603 bp from pter |
End:
|
4,792,839 bp from pter |
Size:
|
4,237 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for KCNA6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily A member 6 Size: 529 amino acids; 58729 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane proteinPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002226.1
ENSEMBL proteins: ENSP00000280684
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNA6: Assays for KCNA6: | Protein
Domains/ Families for KCNA6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P17658
ProtoNet protein and cluster: P17658 4 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003972 Skaker voltage-gated K+ channel family signature IPB004053 Kv1.6 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartmentsDomain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. A (Shaker) subfamily | Gene Function for KCNA6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002235
Applied Biosystems Silencer® siRNAs for KCNA6
Sigma-Aldrich siRNA and siRNA Panels for KCNA6  Sigma-Aldrich shRNA Panels and shRNA for KCNA6  Explore Sigma-Aldrich super-pooled esiRNAs 
| Clones: |  | Invitrogen Clones for KCNA6 | |  | Millipore Clones for the Expression of KCNA6 |               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002235                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002235                                  untagged cDNA clone in CMV expression vector: NM_002235 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002235
UniProtKB/Swiss-Prot: KCNA6_HUMAN, P17658Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradientGenatlas biochemistry entry for KCNA6:potassium voltage-gated channel,Drosophila shaker-related subfamily,member 6 (mouse Kv1.6 homolog)3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Kcna6):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KCNA6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/44 Interacting proteins for KCNA6 (ENSP000002806843) via UniProtKB, MINT, and/or STRING (see all 44
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNA6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for KCNA6 |
Compounds for KCNA6 available from Tocris Bioscience About this table
1 Novoseek chemical compound relationship for KCNA6 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| potassium |
47.41 |
2 |
8719753 (1) |
About this table
|
Transcripts for KCNA6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002235
Sigma-Aldrich siRNA and siRNA Panels for KCNA6  Sigma-Aldrich shRNA Panels and shRNA for KCNA6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002235 REFSEQ mRNAs for KCNA6 gene: NM_002235.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002235               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002235                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002235                                  untagged cDNA clone in CMV expression vector: NM_002235  Additional cDNA sequence: AK057863.1 6 DOTS entries: DT.100017225 DT.442806 DT.121205686 DT.121205638 DT.121205631 DT.91694726 24/60 AceView cDNA sequences (see all 60
):AJ505959 BM719843 BC069355 AJ271385 BM852999 AA609028 BQ774134 CD724101 AA242896 CA442989 NM_017417 BX090709 AA812749 AK057863 AA082821 AA082828 CB153065 AI655634 BM984255 AA083815 BM971346 BQ128051 AW005440 BF057823
highest scoring ESTs for KCNA6:X17622 BC069355 BE700671 BF115418 BF930901 BX501195 CB153065 R15156 T28887 BI039546 Unigene Clusters for KCNA6: Potassium voltage-gated channel, shaker-related subfamily, member 6 Hs.306190 [show with all ESTs], Hs.426162 [show with all ESTs]Unigene Representative Sequences: NM_002235, AK057863
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000280684
|
Expression for KCNA6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNA6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNA6
1 / 2 / 3 4 probe-sets matching KCNA6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.306190 Hs.426162
Expression variation in blood from EXPOLDB for KCNA6 |
Orthologs for KCNA6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNA6 gene from 5/8 species (see all 8
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
KCNA61 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
99.05(n) 99.24(a) |
747272 XM_001159166.1 XP_001159166.1 |
cow (Bos taurus) |
KCNA61 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
91.33(n) 96.2(a) |
539714 XM_588936.3 XP_588936.2 |
rat (Rattus norvegicus) |
Kcna61 |
-- |
potassium voltage gated channel, shaker related subfamily, more |
86.45(n) 92.82(a) |
64358 XM_575671.2 XP_575671.1 |
mouse (Mus musculus) |
Kcna61, 5 |
6 (61.00 cM)5
|
potassium voltage-gated channel, shaker-related, subfamily, more1, 5 |
86.3(n)1 93.18(a)1 |
164941 NM_013568.51 NP_038596.11 AK0318905 AK1344775 (see all 9) |
zebrafish (Danio rerio) |
LOC7954901 |
-- |
similar to shaker-related potassium channel Tsha2 |
66.33(n) 74.56(a) |
795490 XM_001335643.2 XP_001335679.2 |
About this table Species with no ortholog for KCNA6
ENSEMBL Gene Tree for KCNA6 | Paralogs for KCNA6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNA6 gene
- KCNA12 KCNA22 KCNA32
|
SNPs/Variants for KCNA6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNA6 (up to first 250kb)
|
Disorders & Mutations for KCNA6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 176257
|
Medical News for KCNA6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNA6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for KCNA6 gene (see all 13
):- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)2, 3 Gutman G.A....Wang X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. (PubMed id 2347305)3, 4 Grupe A.... Pongs O. (1990)
- Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. (PubMed id 8821794)1, 3 Albrecht B....Pongs O. (1995)
- Clinical spectrum of voltage-gated potassium channel autoimmunity. (PubMed id 18474843)3 Tan K.M....Pittock S.J. (2008)
- The RCK2 domain of the human BKCa channel is a calcium sensor. (PubMed id 18162557)3 Yusifov T....Olcese R. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Analysis of a human brain voltage-gated potassium channel gene, KCNA6 (HBK2), in patients with juvenile myoclonic epilepsy. (PubMed id 8719753)1 Rees M....Gardiner M. (1995)
- Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)1 Klocke R....Jockusch H. (1993)
- Inherited neuromyotonia: a clinical and genetic study of a family. (PubMed id 17140792)1 Falace A....Zara F. (2007)
|
Search for KCNA6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNA6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNA6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNA6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNA6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNA6:

 | |
 | | | | |
|
 |  |  |
| | | | Tocris compounds for KCNA6 |
|
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Incremental update: 13 Oct 2009
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