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KCNA5 Gene

protein-coding GIFtS: 63

GC12P005023

potassium voltage-gated channel, shaker-related subfamily, member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ATFB7 ^², ⁵
HCK1 ^²
HK2 ^¹, ², ³
HPCN1 ^¹, ², ³
KV1.5 ^²
Kv1.5 ^¹
MGC117058 ^²
MGC117059 ^²
PCN1 ^²

Descriptions
Voltage-gated potassium channel subunit Kv1.5 ^³
cardiac potassium channel ^²
insulinoma and islet potassium channel ^²
potassium channel 1 ^²
potassium channel protein ^²
potassium voltage-gated channel, shaker-related subfamily, member 5 ^²
voltage-gated potassium channel protein Kv1.5 ^²

External Ids
HGNC: 6224¹
Entrez Gene: 3741²
UniProtKB: P22460³
Ensembl: ENSG00000130037⁷

Search outside databases for aliases for KCNA5 gene

Previous GC identifers: GC12P004890 GC12P005045

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNA5:

Potassium channels represent the most complex class of voltage-gated ino channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter

release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport,

smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes -

shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have

human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,

shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type

repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which

could restore the resting membrane potential of beta cells after depolarization and thereby

contribute to the regulation of insulin secretion. This gene is intronless, and the gene is

clustered with genes KCNA1 and KCNA6 on chromosome 12. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potasssium ions may pass in

accordance with their electrochemical gradient. May play a role in regulating the secretion of

insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from

inactivation and an excessive cumulative inactivation

Gene Wiki entry for KCNA5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNA5 gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13

KCNA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P005023: (about GC identifiers)

Start:	5,023,346 bp from pter
End:	5,026,210 bp from pter
Size:	2,865 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily A member 5

Size: 613 amino acids; 67228 Da

Subunit: Heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel

currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with UBE2I

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q4KKT8 Q4VAJ1 Q4VAJ2

Alternative splicing: 2 isoforms: P22460-1 P22460-2

Post-translational modifications:

Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage

sensitivity of the channel¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002225.2

ENSEMBL proteins:

ENSP00000252321

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNA5 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNA5)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IDA	16780588
GO:0005886	plasma membrane	IDA	16780588
GO:0008076	voltage-gated potassium channel complex	TAS	1986382
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNA5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNA5
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNA5), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KCNA5

Assays for KCNA5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22460

ProtoNet protein and cluster: P22460

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003972 Skaker voltage-gated K+ channel family signature

IPB004052 Kv1.5 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460

Domain: The amino terminus may be important in determining the rate of inactivation of the channel

while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or

targeting of the channel to specific subcellular compartments

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. A (Shaker) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002234

Applied Biosystems Silencer® siRNAs for KCNA5

Sigma-Aldrich siRNA and siRNA Panels for KCNA5

Sigma-Aldrich shRNA Panels and shRNA for KCNA5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of KCNA5

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002234
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002234
untagged cDNA clones in CMV expression vector (see all 2): NM_002234

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002234

UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potasssium ions may pass in

accordance with their electrochemical gradient. May play a role in regulating the secretion of

insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from

inactivation and an excessive cumulative inactivation

Genatlas biochemistry entry for KCNA5:

potassium voltage-gated channel,Drosophila shaker-related subfamily,member 5 (mouse Kv1.5 homolog)

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcna5):

	cellular	hematopoietic system	homeostasis/metabolism	immune system
muscle	nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005251	delayed rectifier potassium channel activity	TAS	1986382
GO:0005515	protein binding	IEA	--
GO:0019870	potassium channel inhibitor activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNA5

5/56 Interacting proteins for KCNA5 (ENSP00000252321³ P22460²) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTN2	P35609²	STRING (score=.991) MINT-17650 MINT-17651
KCNIP2	ENSP00000347877³	STRING (score=.995)
KCNE2	ENSP00000290310³	STRING (score=.987)
KCNH2	ENSP00000262186³	STRING (score=.984)
KCNE1	ENSP00000337255³	STRING (score=.978)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0042391	regulation of membrane potential	IEA	--
GO:0043267	negative regulation of potassium ion transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNA5 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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3 Novoseek chemical compound relationships for KCNA5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	68.47	15	15541182 (2), 7587392 (1), 9694927 (1), 12208779 (1) (see all 13)
calcium	19.17	3	15353504 (1), 17085423 (1)
oxygen	6.48	2	16735674 (1), 8524851 (1)

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1 PharmGKB drug compound relationship for KCNA5 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA GN	2001794

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002234

Sigma-Aldrich siRNA and siRNA Panels for KCNA5

Sigma-Aldrich shRNA Panels and shRNA for KCNA5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002234

REFSEQ mRNAs for KCNA5 gene:

NM_002234.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002234

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002234
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002234
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002234

Additional cDNA sequence:

BC096357.3 BC096358.3 BC099665.3 BC099666.3 M55513.1 M60451.1 M83254.1

2 DOTS entries:

DT.87015787 DT.97839754

24/25 AceView cDNA sequences (see all 25 ):

BQ189575 AA975384 NM_002234 BM692565 BM663787 BQ417402 CK823380 BV205997

M60451 AW074733 AI377563 M83254 CK823379 BX280957 BM893755 BI764377

BE350646 M55513 BM967038 BV205996 AA218863 BQ287945 AW242568 BM725344

highest scoring ESTs for KCNA5:

M55513 AA218863 AA975384 AI377563 AW074733 BE350646 BI764377 BM663787 BM692565 BM893755

Unigene Cluster for KCNA5:

Potassium voltage-gated channel, shaker-related subfamily, member 5

Hs.150208 [show with all ESTs]

Unigene Representative Sequence: M55513

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000252321

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNA5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNA5

¹ / ² / ³

3 probe-sets matching KCNA5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34981_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	M55513	1.00	1.00	1.00	1
206762_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002234	0.60	1.00	0.82	1
206762_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNA5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.150208
Expression variation in blood from EXPOLDB for KCNA5
UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460
Tissue specificity: Pancreatic islets and insulinoma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNA5 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNA5¹	--	potassium voltage-gated channel, shaker-related subfamily, more	90.08(n) 89.97(a)	403995 NM_001006645.1 NP_001006646.1
chimpanzee (Pan troglodytes)	KCNA5¹	--	potassium voltage-gated channel, shaker-related subfamily, more	99.45(n) 99.67(a)	466930 XM_522330.2 XP_522330.1
cow (Bos taurus)	KCNA5¹	--	potassium voltage-gated channel, shaker-related subfamily, more	87.49(n) 88.27(a)	508960 NM_001015552.1 NP_001015552.1
rat (Rattus norvegicus)	Kcna5¹	--	potassium voltage-gated channel, shaker-related subfamily, more	84.22(n) 88.17(a)	25470 NM_012972.1 NP_037104.1
mouse (Mus musculus)	Kcna5^{1, 5}	6 (61.00 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	84.61(n)¹ 88.5(a)¹	16493¹ NM_145983.1¹ NP_666095.1¹ AF108659⁵ AF302768⁵ (see all 10)

About this table Species with no ortholog for KCNA5

ENSEMBL Gene Tree for KCNA5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNA5 gene

KCNA4² KCNA10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in KCNA5 are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2239507^1,2	A,C,F,H,O	5021395(+)	`TGTCTT/GCAAGC`	1	--	ng5¹		11	EA EU WA NA	3148
	rs1860420^1,2	A,C,F,H,O	5026536(-)	`CCCAAC/TAAGAC`	1	--	ng3¹		9	NA EA EU WA	2120
	rs3741930^1,2	A,C,F,H	5023408(+)	`GGCTTC/TTTGAC`	1	--	ut5¹ ese³		16	EA NA EU WA	3572
--	rs1056468^1,2	A,C,F,H	5025924(+)	`GAAAGA/TGTTGT`	1	--	ut3¹ trp³		11	MN EU EA WA	2048
	rs10744676^1,2	A,C,F,H	5023210(+)	`GACACT/CCGCTG`	1	--	ng5¹		6	EU EA WA	1308
	rs11615552^1,2	A,C,F,H	5022837(+)	`ATACAT/CGTATT`	1	--	ng5¹		15	NA EU EA WA	1898
	rs17785024^1,2	C,F,H	5022551(+)	`TGCTCG/TGTCCA`	1	--	ng5¹		7	NA EU EA WA	550
	rs4625555^1,2	C,F,H	5026216(+)	`GGCAAG/ATGTTA`	1	--	ng3¹		9	EU EA WA NA	1594
	rs1056464^1,2	C,F,H	5024256(+)	`CCCTGC/TCCCGC`	1	P/S	mis¹ ese³		5	MN EU EA WA	590
	rs2284136^1,2	C,F,H	5022259(+)	`gtttcC/Tacctg`	1	--	ng5¹		11	EA EU WA	3212

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HapMap Linkage Disequilibrium images for KCNA5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176267 disorders: 612240

UniProtKB/Swiss-Prot: KCNA5_HUMAN, P22460

Defects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7)

[MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a

small subgroup of patients. It is characterized by disorganized atrial electrical activity,

progressive deterioration of atrial electromechanical function and ineffective pumping of blood

into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and

congestive heart failure

6 Novoseek disease relationships for KCNA5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertension arterial	57.73	3	17267549 (1), 15140747 (1), 11950153 (1)
atrial fibrillation	19.34	1	15807513 (1)
arrhythmia	13.20	2	17266934 (1)
cancer	0.00	1	15541182 (1)
tumors	0.00	1	15541182 (1)
metastasis	0.00	1	11212253 (1)

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Human Gene Mutation Database: KCNA5
Human Genome Epidemiology Navigator: KCNA5 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/103 PubMed articles for KCNA5 gene (see all 103 ):

Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. (PubMed id 2001794)^{3, 4, 7} Tamkun M.M....Glover D.M. (1991)
Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PubMed id 1986382)^{1, 3, 4} Philipson L.H.... Steiner D.F. (1991)
A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. (PubMed id 16466689)^{1, 3, 4} Mathur R....Fedida D. (2006)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
Molecular cloning, characterization, and genomic localization of a human potassium channel gene. (PubMed id 1349297)^{3, 4} Curran M.E.... Keating M.T. (1992)
Overexpression of human KCNA5 increases IK V and enhances apoptosis. (PubMed id 15140747)^{1, 3} Brevnova E.E....Yuan J.X. (2004)
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. (PubMed id 17267549)^{1, 3} Remillard C.V....Yuan J.X. (2007)
Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. (PubMed id 16236819)^{1, 3} Platoshyn O....Yuan J.X. (2006)
Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. (PubMed id 12850541)^{1, 3} Preussat K....Patt S. (2003)
Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. (PubMed id 15217912)^{1, 3} Archer S.L....Michelakis E.D. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3741	HGNC: 6224	AceView: KCNA5	Ensembl:ENSG00000130037	euGenes: HUgn3741
ECgene: KCNA5	H-InvDB: KCNA5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNA5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNA5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNA5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNA5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNA5		Browse small molecules at Sigma-Aldrich
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KCNA5 Gene at Home site.
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KCNA5 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for KCNA5

Summaries
for KCNA5

Genomic Location
for KCNA5

Proteins
for KCNA5

Protein Domains/
Families
for KCNA5

Gene Function
for KCNA5

Pathways & Interactions
for KCNA5

Drugs & Compounds
for KCNA5

Transcripts
for KCNA5

Expression
for KCNA5

Orthologs
for KCNA5

Paralogs
for KCNA5

SNPs/Variants
for KCNA5

Disorders & Mutations
for KCNA5

Medical News
for KCNA5

Publications
for KCNA5

Search for KCNA5

Genome Databases showing KCNA5

Other Databases showing KCNA5

Specialized Databases showing KCNA5

Licensable Technologies
for KCNA5

Services
for KCNA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNA5 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor KCNA5

Summariesfor KCNA5

Genomic Locationfor KCNA5

Proteinsfor KCNA5

Protein Domains/Familiesfor KCNA5

Gene Functionfor KCNA5

Pathways & Interactionsfor KCNA5

Drugs & Compoundsfor KCNA5

Transcriptsfor KCNA5

Expression for KCNA5

Orthologsfor KCNA5

Paralogsfor KCNA5

SNPs/Variantsfor KCNA5

Disorders & Mutationsfor KCNA5

Medical Newsfor KCNA5

Publicationsfor KCNA5

Search for KCNA5

Genome Databases showing KCNA5

Other Databases showing KCNA5

Specialized Databases showing KCNA5

Licensable Technologiesfor KCNA5

Servicesfor KCNA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNA5

Summaries
for KCNA5

Genomic Location
for KCNA5

Proteins
for KCNA5

Protein Domains/
Families
for KCNA5

Gene Function
for KCNA5

Pathways & Interactions
for KCNA5

Drugs & Compounds
for KCNA5

Transcripts
for KCNA5

Expression
for KCNA5

Orthologs
for KCNA5

Paralogs
for KCNA5

SNPs/Variants
for KCNA5

Disorders & Mutations
for KCNA5

Medical News
for KCNA5

Publications
for KCNA5

Licensable Technologies
for KCNA5

Services
for KCNA5