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Aliases for KCNA5 Gene

Aliases for KCNA5 Gene

  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 5 2 3
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.5 3 4
  • Voltage-Gated Potassium Channel HK2 3 4
  • ATFB7 3 6
  • HPCN1 3 4
  • Potassium Voltage-Gated Channel Subfamily A Member 5 3
  • Voltage-Gated Potassium Channel Protein Kv1.5 3
  • Insulinoma And Islet Potassium Channel 3
  • Cardiac Potassium Channel 3
  • Potassium Channel 1 3
  • KV1.5 3
  • HCK1 3
  • PCN1 3
  • HK2 3

External Ids for KCNA5 Gene

Previous GeneCards Identifiers for KCNA5 Gene

  • GC12P004890
  • GC12P005045
  • GC12P005023
  • GC12P005153

Summaries for KCNA5 Gene

Entrez Gene Summary for KCNA5 Gene

  • Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

GeneCards Summary for KCNA5 Gene

KCNA5 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 5) is a Protein Coding gene. Diseases associated with KCNA5 include atrial fibrillation, familial, 7 and kcna5-related familial atrial fibrillation. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein kinase binding and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA5 Gene

  • Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).

Tocris Summary for KCNA5 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA5 Gene

Genomics for KCNA5 Gene

Regulatory Elements for KCNA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNA5 Gene

Start:
5,043,919 bp from pter
End:
5,046,788 bp from pter
Size:
2,870 bases
Orientation:
Plus strand

Genomic View for KCNA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA5 Gene

Proteins for KCNA5 Gene

  • Protein details for KCNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22460-KCNA5_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 5
    Protein Accession:
    P22460
    Secondary Accessions:
    • Q4KKT8
    • Q4VAJ1
    • Q4VAJ2
    • Q9UDA4

    Protein attributes for KCNA5 Gene

    Size:
    613 amino acids
    Molecular mass:
    67228 Da
    Quaternary structure:
    • Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (PubMed:12130714). Interacts with UBE2I (PubMed:17261810).
    SequenceCaution:
    • Sequence=AAA60146.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNA5 Gene

Proteomics data for KCNA5 Gene at MOPED

Post-translational modifications for KCNA5 Gene

  • Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
  • Glycosylation at Asn125 and Asn190
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA5 Gene

Domains for KCNA5 Gene

Gene Families for KCNA5 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22460

UniProtKB/Swiss-Prot:

KCNA5_HUMAN :
  • P22460
Domain:
  • The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
genes like me logo Genes that share domains with KCNA5: view

Function for KCNA5 Gene

Molecular function for KCNA5 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila shaker-related subfamily,member 5 (mouse Kv1.5 homolog)
UniProtKB/Swiss-Prot Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).

Gene Ontology (GO) - Molecular Function for KCNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IMP 19343045
GO:0005515 protein binding IPI 10812072
genes like me logo Genes that share ontologies with KCNA5: view
genes like me logo Genes that share phenotypes with KCNA5: view

Animal Models for KCNA5 Gene

MGI Knock Outs for KCNA5:

Animal Model Products

CRISPR Products

miRNA for KCNA5 Gene

miRTarBase miRNAs that target KCNA5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNA5 Gene

Localization for KCNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA5 Gene COMPARTMENTS Subcellular localization image for KCNA5 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA 16780588
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12130714
GO:0005901 colocalizes_with caveola TAS 17060380
genes like me logo Genes that share ontologies with KCNA5: view

Pathways for KCNA5 Gene

genes like me logo Genes that share pathways with KCNA5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KCNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006811 ion transport --
GO:0006813 potassium ion transport IDA 8576199
GO:0007268 synaptic transmission TAS --
GO:0019229 regulation of vasoconstriction IEA --
genes like me logo Genes that share ontologies with KCNA5: view

Compounds for KCNA5 Gene

(5) Tocris Compounds for KCNA5 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(8) IUPHAR Ligand for KCNA5 Gene

Ligand Type Action Affinity Pubmed IDs
clofilium Pore Blocker None 6.6
S9947 Pore Blocker None 6.4
propafenone Pore Blocker None 5.4
bupivacaine Pore Blocker None 5.4
flecainide Pore Blocker None 5.1
quinidine Inhibitor Inhibition
resiniferatoxin Activator None
nifedipine Activator None

(9) Novoseek inferred chemical compound relationships for KCNA5 Gene

Compound -log(P) Hits PubMed IDs
dichloroacetate 73.8 1
4-aminopyridine 70.8 3
potassium 67.9 15
terfenadine 60.9 4
benzocaine 60.3 2
genes like me logo Genes that share compounds with KCNA5: view

Transcripts for KCNA5 Gene

mRNA/cDNA for KCNA5 Gene

(7) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA5 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA5 Gene

No ASD Table

Relevant External Links for KCNA5 Gene

GeneLoc Exon Structure for
KCNA5
ECgene alternative splicing isoforms for
KCNA5

Expression for KCNA5 Gene

mRNA expression in normal human tissues for KCNA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA5 Gene

This gene is overexpressed in Artery - Coronary (9.1), Heart - Atrial Appendage (8.8), Artery - Tibial (8.5), and Artery - Aorta (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNA5 Gene

SOURCE GeneReport for Unigene cluster for KCNA5 Gene Hs.150208

mRNA Expression by UniProt/SwissProt for KCNA5 Gene

P22460-KCNA5_HUMAN
Tissue specificity: Pancreatic islets and insulinoma
genes like me logo Genes that share expressions with KCNA5: view

In Situ Assay Products

Orthologs for KCNA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA5 35
  • 99.39 (n)
  • 99.67 (a)
KCNA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNA5 35
  • 87.44 (n)
  • 88.11 (a)
KCNA5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA5 35
  • 90.08 (n)
  • 89.97 (a)
KCNA5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna5 35
  • 84.28 (n)
  • 88 (a)
Kcna5 16
Kcna5 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNA5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kcna5 35
  • 83.95 (n)
  • 88.09 (a)
chicken
(Gallus gallus)
Aves KCNA5 35
  • 70.8 (n)
  • 71.94 (a)
KCNA5 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna5 35
  • 71.6 (n)
  • 80.9 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01083827.1 36
  • 68 (a)
OneToOne
LOC100004160 35
  • 73.1 (n)
  • 78.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sh 36
  • 47 (a)
OneToMany
Sh 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
Species with no ortholog for KCNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA5 Gene

ENSEMBL:
Gene Tree for KCNA5 (if available)
TreeFam:
Gene Tree for KCNA5 (if available)

Paralogs for KCNA5 Gene

Selected SIMAP similar genes for KCNA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA5: view

Variants for KCNA5 Gene

Sequence variations from dbSNP and Humsavar for KCNA5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1056461 -- 5,044,050(+) GCCGA(C/G)GCTGG utr-variant-5-prime
rs1056462 -- 5,044,531(+) TCCGG(C/G)CTGCG synonymous-codon, reference
rs1056463 -- 5,044,560(+) CACCC(A/T)GGCGC missense, reference
rs1056464 - 5,044,829(+) CCCTG(C/T)CCCGC reference, missense
rs1056466 -- 5,046,393(+) TAGGG(C/G)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNA5 Gene

Variant ID Type Subtype PubMed ID
nsv898626 CNV Loss 21882294
nsv517406 CNV Loss 19592680

Relevant External Links for KCNA5 Gene

HapMap Linkage Disequilibrium report
KCNA5
Human Gene Mutation Database (HGMD)
KCNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA5 Gene

Disorders for KCNA5 Gene

(1) OMIM Diseases for KCNA5 Gene (176267)

UniProtKB/Swiss-Prot

KCNA5_HUMAN
  • Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:16772329}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for KCNA5 Gene

(6) Novoseek inferred disease relationships for KCNA5 Gene

Disease -log(P) Hits PubMed IDs
hypertension arterial 60.5 4
atrial fibrillation 16.5 1
arrhythmia 10.8 1
metastasis 0 1
tumors 0 1

Relevant External Links for KCNA5

Genetic Association Database (GAD)
KCNA5
Human Genome Epidemiology (HuGE) Navigator
KCNA5
genes like me logo Genes that share disorders with KCNA5: view

Publications for KCNA5 Gene

  1. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PMID: 1986382) Philipson L.H. … Steiner D.F. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. (PMID: 16466689) Mathur R. … Fedida D. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Overexpression of human KCNA5 increases IK V and enhances apoptosis. (PMID: 15140747) Brevnova E.E. … Yuan J.X. (Am. J. Physiol., Cell Physiol. 2004) 3 23
  4. Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. (PMID: 15217912) Archer S.L. … Michelakis E.D. (Circ. Res. 2004) 3 23
  5. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (PMID: 15353504) ThAcbaud B. … Archer S.L. (Circulation 2004) 3 23

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