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Aliases for KCNA4 Gene

Aliases for KCNA4 Gene

  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 4 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.4 3 4
  • Voltage-Gated Potassium Channel HBK4 3 4
  • Voltage-Gated Potassium Channel HK1 3 4
  • Voltage-Gated K(+) Channel HuKII 3 4
  • KCNA4L 3 4
  • HPCN2 3 4
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4-Like 2
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 2
  • Fetal Skeletal Muscle Potassium Channel 3
  • Rapidly Inactivating Potassium Channel 3
  • Shaker-Related Potassium Channel Kv1.4 3
  • Cardiac Potassium Channel 3
  • Type A Potassium Channel 3
  • Potassium Channel 2 3
  • HUKII 3
  • KCNA8 3
  • KV1.4 3
  • HBK4 3
  • PCN2 3
  • HK1 3

External Ids for KCNA4 Gene

Previous HGNC Symbols for KCNA4 Gene

  • KCNA4L

Previous GeneCards Identifiers for KCNA4 Gene

  • GC11M031625
  • GC11M030806
  • GC11M030070
  • GC11M029996
  • GC11M029988
  • GC11M029724
  • GC11M030031

Summaries for KCNA4 Gene

Entrez Gene Summary for KCNA4 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]

GeneCards Summary for KCNA4 Gene

KCNA4 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 4) is a Protein Coding gene. Diseases associated with KCNA4 include thymus cancer and nasopharyngeal carcinoma. Among its related pathways are Central carbon metabolism in cancer and Metabolism. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA4 Gene

  • Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).

Tocris Summary for KCNA4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA4 Gene

Genomics for KCNA4 Gene

Genomic Location for KCNA4 Gene

Chromosome:
11
Start:
30,009,741 bp from pter
End:
30,017,030 bp from pter
Size:
7,290 bases
Orientation:
Minus strand

Genomic View for KCNA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA4 Gene

Proteins for KCNA4 Gene

  • Protein details for KCNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22459-KCNA4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 4
    Protein Accession:
    P22459

    Protein attributes for KCNA4 Gene

    Size:
    653 amino acids
    Molecular mass:
    73257 Da
    Quaternary structure:
    • Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity). Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with SIGMAR1 (By similarity). Detected in a complex with KCNA1 (By similarity). Interacts with KCNA2 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity). Interacts (via cytoplasmic N-terminal domain) with KCNRG (PubMed:19968958).

neXtProt entry for KCNA4 Gene

Proteomics data for KCNA4 Gene at MOPED

Post-translational modifications for KCNA4 Gene

  • Glycosylation at Asn 352
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA4 Gene

Domains & Families for KCNA4 Gene

Gene Families for KCNA4 Gene

Suggested Antigen Peptide Sequences for KCNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22459

UniProtKB/Swiss-Prot:

KCNA4_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
genes like me logo Genes that share domains with KCNA4: view

Function for KCNA4 Gene

Molecular function for KCNA4 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 4 (mouse Kv1.4 homolog)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 4-aminopyridine (4-AP), but not by tetraethylammonium (TEA) and charybdotoxin (CTX).
UniProtKB/Swiss-Prot Function:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).

Gene Ontology (GO) - Molecular Function for KCNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity IMP 19912772
GO:0005251 NOT delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity --
GO:0005515 protein binding IPI 7477295
genes like me logo Genes that share ontologies with KCNA4: view
genes like me logo Genes that share phenotypes with KCNA4: view

Animal Models for KCNA4 Gene

MGI Knock Outs for KCNA4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KCNA4 Gene

Localization for KCNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA4 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA4 Gene COMPARTMENTS Subcellular localization image for KCNA4 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 8495559
GO:0008076 voltage-gated potassium channel complex ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane ISS --
genes like me logo Genes that share ontologies with KCNA4: view

Pathways & Interactions for KCNA4 Gene

genes like me logo Genes that share pathways with KCNA4: view

Gene Ontology (GO) - Biological Process for KCNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 2001794
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNA4: view

No data available for SIGNOR curated interactions for KCNA4 Gene

Drugs & Compounds for KCNA4 Gene

(8) Drugs for KCNA4 Gene - From: NovoSeek, DrugBank, Tocris, IUPHAR, HMDB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dalfampridine Approved Pharma Inhibitor, Target, antagonist 47
Gliquidone Approved Pharma 5
Tolbutamide Approved Pharma Inhibitor CAMP inhibitor 21
Dopamine Approved Pharma Full agonist, Agonist 2814
Potassium Experimental Pharma 0

(4) Additional Compounds for KCNA4 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Kaliotoxin
145199-73-1
L-364,373
103342-82-1
PD 118057
313674-97-4
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with KCNA4: view

Transcripts for KCNA4 Gene

mRNA/cDNA for KCNA4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA4 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA4 Gene

No ASD Table

Relevant External Links for KCNA4 Gene

GeneLoc Exon Structure for
KCNA4
ECgene alternative splicing isoforms for
KCNA4

Expression for KCNA4 Gene

mRNA expression in normal human tissues for KCNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x12.7), Brain - Caudate (basal ganglia) (x7.1), and Brain - Putamen (basal ganglia) (x6.0).

Protein differential expression in normal tissues from HIPED for KCNA4 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNA4 Gene



SOURCE GeneReport for Unigene cluster for KCNA4 Gene Hs.592002

mRNA Expression by UniProt/SwissProt for KCNA4 Gene

P22459-KCNA4_HUMAN
Tissue specificity: Detected in heart ventricle.
genes like me logo Genes that share expression patterns with KCNA4: view

Protein tissue co-expression partners for KCNA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KCNA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNA4 35
  • 89.72 (n)
  • 96.32 (a)
KCNA4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA4 35
  • 82.9 (n)
  • 88.79 (a)
KCNA4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna4 35
  • 91.07 (n)
  • 97.4 (a)
Kcna4 16
Kcna4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNA4 35
  • 99.85 (n)
  • 100 (a)
KCNA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcna4 35
  • 90.61 (n)
  • 97.24 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNA4 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA4 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA4 35
  • 72.48 (n)
  • 78.87 (a)
KCNA4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna4 35
  • 70.1 (n)
  • 76.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398211 35
zebrafish
(Danio rerio)
Actinopterygii kcna4 35
  • 67.57 (n)
  • 71.54 (a)
KCNA4 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 67 (a)
Sh 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
Species with no ortholog for KCNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA4 Gene

ENSEMBL:
Gene Tree for KCNA4 (if available)
TreeFam:
Gene Tree for KCNA4 (if available)

Paralogs for KCNA4 Gene

(14) SIMAP similar genes for KCNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA4: view

Variants for KCNA4 Gene

Sequence variations from dbSNP and Humsavar for KCNA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs506940 -- 30,015,923(+) TCTCA(A/C)CCCTC intron-variant
rs521068 -- 30,015,167(-) TCAGG(A/C)AAAGG intron-variant
rs534311 -- 30,015,235(-) GTTTT(A/G)TAAGT intron-variant
rs1323860 -- 30,013,689(-) TGAGT(C/T)ACCAT intron-variant
rs1436095 -- 30,018,102(-) CATAC(A/G/T)TCCTA upstream-variant-2KB

Variation tolerance for KCNA4 Gene

Residual Variation Intolerance Score: 8.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA4 Gene

HapMap Linkage Disequilibrium report
KCNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNA4 Gene

Disorders for KCNA4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KCNA4 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
thymus cancer
  • thymoma
nasopharyngeal carcinoma
  • malignant neoplasm of nasopharynx
- elite association
Search KCNA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNA4

Human Genome Epidemiology (HuGE) Navigator
KCNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA4
genes like me logo Genes that share disorders with KCNA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA4 Gene

Publications for KCNA4 Gene

  1. Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression. (PMID: 19968754) Utsunomiya I. … Taguchi K. (J. Neurochem. 2010) 23 67
  2. A hierarchy of cell intrinsic and target-derived homeostatic signaling. (PMID: 20434999) Bergquist S. … Davis G.W. (Neuron 2010) 23 67
  3. Local control of postinhibitory rebound spiking in CA1 pyramidal neuron dendrites. (PMID: 20445069) Ascoli G.A. … Migliore M. (J. Neurosci. 2010) 23 67
  4. Role of p38 MAPKs in hypericin photodynamic therapy-induced apoptosis of nasopharyngeal carcinoma cells. (PMID: 19496992) Chan P.S. … Mak N.K. (Photochem. Photobiol. 2009) 23 67
  5. NMR assignments of a 48 kDa tetramer of the T1 domain of the mammalian voltage gated potassium channel Kv1.4. (PMID: 19888682) Schreier C. … Kremer W. (Biomol NMR Assign 2009) 23 67

Products for KCNA4 Gene

Sources for KCNA4 Gene

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