Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNA4 Gene

protein-coding   GIFtS: 64
GCID: GC11M030031

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

(Previous names: potassium voltage-gated channel, shaker-related subfamily,...)
(Previous symbol: KCNA4L)
  See KCNA4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 41 2     HUKII2
KCNA4L1 2 3     KV1.42
Voltage-Gated K(+) Channel HuKII2 3     PCN22
Voltage-Gated Potassium Channel HBK42 3     Cardiac Potassium Channel2
Voltage-Gated Potassium Channel HK12 3     Fetal Skeletal Muscle Potassium Channel2
Voltage-Gated Potassium Channel Subunit Kv1.42 3     Potassium Channel 22
HPCN22 3     Potassium Voltage-Gated Channel Subfamily A Member 42
KCNA82 5     Rapidly Inactivating Potassium Channel2
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4-Like1     Shaker-Related Potassium Channel Kv1.42
HBK42     Type A Potassium Channel2
HK12     

External Ids:    HGNC: 62221   Entrez Gene: 37392   Ensembl: ENSG000001822557   OMIM: 1762665   UniProtKB: P224593   

Export aliases for KCNA4 gene to outside databases

Previous GC identifers: GC11M031625 GC11M030806 GC11M030070 GC11M029996 GC11M029988 GC11M029724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KCNA4 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which
may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may
influence the duration of cardiac action potential.(provided by RefSeq, Mar 2011)

GeneCards Summary for KCNA4 Gene:
KCNA4 (potassium voltage-gated channel, shaker-related subfamily, member 4) is a protein-coding gene. Diseases associated with KCNA4 include episodic ataxia type 1, and pancreas adenocarcinoma. GO annotations related to this gene include potassium ion binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient

summary for KCNA4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNA4 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   MIF-1   POU3F2   LCR-F1   FOXL1   C/EBPalpha   CHOP-10   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA4 promoter sequence
   Search Chromatin IP Primers for KCNA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14

KCNA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030031:  view genomic region     (about GC identifiers)

Start:
30,031,288 bp from pter      End:
30,038,577 bp from pter
Size:
7,290 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 4  
Size: 653 amino acids; 73257 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with
SIGMAR1 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity)

Explore the universe of human proteins at neXtProt for KCNA4: NX_P22459

Explore proteomics data for KCNA4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn181, Asn352
  • Modification sites at PhosphoSitePlus

  • See KCNA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002224.1  
    ENSEMBL proteins: 
     ENSP00000328511  
    Reactome Protein details: P22459

    KCNA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCNA4
    GenScript Custom Purified and Recombinant Proteins Services for KCNA4
    Novus Biologicals KCNA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNA4

     
    Search eBioscience for Proteins for KCNA4 

     
    antibodies-online proteins for KCNA4 (2 products) 

     
    Search antibodies-online for peptides for KCNA4

    KCNA4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCNA4
    Novus Biologicals KCNA4 Antibodies
    Abcam antibodies for KCNA4
    Cloud-Clone Corp. Antibodies for KCNA4
    ThermoFisher Antibodies for KCNA4
    LSBio Antibodies in human, mouse, rat for KCNA4
    antibodies-online antibodies for KCNA4 (63 products) 

    KCNA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNA4
    Cloud-Clone Corp. CLIAs for KCNA4
    Search eBioscience for ELISAs for KCNA4 
    antibodies-online kits for KCNA4 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.4
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 11):
     IPR020467 K_chnl_volt-dep_Kv1.4
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P22459

    ProtoNet protein and cluster: P22459

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004051 Kv1.4 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily


    Find genes that share domains with KCNA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA4_HUMAN, P22459
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient

         Genatlas biochemistry entry for KCNA4:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 4 (mouse Kv1.4 homolog)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS2001794
    GO:0005251NOT delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding IPI11937501
    GO:0030955potassium ion binding IEA--
         
    Find genes that share ontologies with KCNA4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNA4:
     Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcna4):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with KCNA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcna4tm1Lndn for KCNA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCNA4:
    hsa-mir-335-5p (MIRT017281)

    Block miRNA regulation of human, mouse, rat KCNA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNA4 (see all 46):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-301a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidKCNA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCNA4
    Predesigned siRNA for gene silencing in human, mouse, rat KCNA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNA4

    Clone
    Products:
         
    OriGene clones in human, mouse for KCNA4 (see all 7)
    OriGene ORF clones in mouse, rat for KCNA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNA4 (NM_002233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCNA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCNA4_HUMAN, P22459: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with KCNA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCNA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Find genes that share SuperPaths with KCNA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNA4
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNA4
        Voltage gated Potassium channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNA4
    Interactions:

        GeneGlobe Interaction Network for KCNA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNA4 (P224591, 2, 3 ENSP000003285114) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783521, 2, 3EBI-631235,EBI-80389 MINT-1901203 MINT-1900477 I2D: score=9 
    ACTN2P356092, 3, ENSP000003555374MINT-14873 MINT-14874 I2D: score=2 STRING: ENSP00000355537
    SAT1P216732, 3MINT-63562 I2D: score=5 
    NDUFA4L2Q9NRX32, 3, ENSP000003774114MINT-65617 I2D: score=5 STRING: ENSP00000377411
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS2001794
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with KCNA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    2 DrugBank Compounds for KCNA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arginineamide-- --target--17139284 17016423 10592235
    Dalfampridine 4-Aminopyridine (see all 5)504-24-5targetantagonist16472864

    1 IUPHAR Ligand for KCNA4 (Kv1.4)    About this table
    LigandTypeActionAffinityPubmed IDs
    4-aminopyridine
    InhibitorNone--

    5 Novoseek inferred chemical compound relationships for KCNA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 76.3 58 20076774 (5), 11598014 (2), 9867876 (2), 19888682 (2) (see all 41)
    4-aminopyridine 49.8 3 7658383 (1), 11743993 (1), 12740404 (1)
    calcium 27.7 7 16837590 (2), 10676964 (1), 11535596 (1), 11165788 (1) (see all 6)
    sodium 17 3 19118105 (1), 16546141 (1)
    dopamine 0 1 15872020 (1)



    Find genes that share compounds with KCNA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCNA4 gene: 
    NM_002233.3  

    Unigene Cluster for KCNA4:

    Potassium voltage-gated channel, shaker-related subfamily, member 4
    Hs.592002  [show with all ESTs]
    Unigene Representative Sequence: NM_002233
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328224(uc001msk.3) ENST00000526518
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCNA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNA4 (see all 46):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-301a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidKCNA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCNA4
    Predesigned siRNA for gene silencing in human, mouse, rat KCNA4
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNA4 (see all 7)
    OriGene ORF clones in mouse, rat for KCNA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNA4 (NM_002233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNA4
      QuantiTect SYBR Green Assays in human, mouse, rat KCNA4
      QuantiFast Probe-based Assays in human, mouse, rat KCNA4

    Additional mRNA sequence: 

    AK313662.1 L02751.1 M55514.1 M60450.1 

    1 DOTS entry:

    DT.306585 

    20 AceView cDNA sequences:

    BX282390 BF223341 BF196130 NM_002233 CF143509 L02751 M60450 BE467209 
    AI793138 AA974913 BE326268 BE467430 AW275993 BX952248 AI733207 M55514 
    AI631014 BF111147 AI694934 AI701825 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCNA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATAATTGT
    KCNA4 Expression
    About this image


    KCNA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Lung (Respiratory System)
    KCNA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592002
        Custom PCR Arrays for KCNA4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNA4
    QuantiTect SYBR Green Assays in human, mouse, rat KCNA4
    QuantiFast Probe-based Assays in human, mouse, rat KCNA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KCNA4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna41 , 5 potassium voltage-gated channel, shaker-related subfamily, member 4 less1, 5 91.07(n)1
    97.4(a)1
      2 (56.12 cM)5
    164921  NM_021275.41  NP_067250.21 
     1072906395 
    chicken
    (Gallus gallus)
    Aves KCNA41 potassium voltage-gated channel, shaker-related subfamily, member 4 less 72.48(n)
    78.87(a)
      395721  NM_204899.1  NP_990230.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA46
    potassium voltage-gated channel, shaker-related su...
    79(a)
    1 ↔ 1
    1(59350772-59352760)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982112 Kv1.4 potassium channel 77.29(n)    AY124705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcna41 potassium voltage-gated channel, shaker-related subfamily, member 4 less 67.57(n)
    71.54(a)
      559036  XM_005168949.1  XP_005169006.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel less
    67(a)     --


    ENSEMBL Gene Tree for KCNA4 (if available)
    TreeFam Gene Tree for KCNA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCNA4 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
    KCNA12  KCNC12  KCNC32  KCNA32  KCND32  KCNA102  
    14 SIMAP similar genes for KCNA4 using alignment to 1 protein entry:     KCNA4_HUMAN:
    KCNA7    KCNA1    KCNA10    KCNA2    KCNA6    KCNA3
    KCNA5    KCNB1    KCNB2    KCND1    KCNF1    KCNC1
    KCNC3    KCNS3

    Find genes that share paralogs with KCNA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCNA4 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893785501,2
    --30030850(+) CCTCAC/TGATTT 1 -- ds50010--------
    rs1820575011,2
    --30031101(+) CTAGCA/GTTTAT 1 -- ds50010--------
    rs771223241,2
    C--30031128(+) AAAAAA/TTTTAA 1 -- ds50010--------
    rs783977741,2
    C,F--30031227(+) GGCAGA/GAGAAT 1 -- ds50013Minor allele frequency- G:0.11WA NA EA 358
    rs802633361,2
    C,F--30031321(+) CTTTGT/CCAATC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1837729071,2
    --30031350(+) AGAGGA/CGAGAA 1 -- ut310--------
    rs1485752271,2
    --30031540(+) GTCCTA/GTTACC 1 -- ut310--------
    rs1881032731,2
    --30031585(+) ACTTAC/TTCTAT 1 -- ut310--------
    rs1444030961,2
    --30031616(+) AAGTCC/TTCCCA 1 -- ut310--------
    rs1809424031,2
    --30031937(+) TTACTA/TCACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNA4 (30031288 - 30038577 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNA4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNA4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 176266    OMIM disorders: --

    2 diseases for KCNA4:    
    About MalaCards
    episodic ataxia type 1    pancreas adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for KCNA4:
    Thymoma     Long QT syndrome     Myasthenia gravis     Myocarditis

    Find genes that share disorders with KCNA4           About GenesLikeMe

    1 Novoseek inferred disease relationship for KCNA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasopharyngeal carcinoma 35.5 2 16142332 (1), 19496992 (1)

    Human Genome Epidemiology (HuGE) Navigator: KCNA4 (2 documents)

    Export disorders for KCNA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCNA4 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with KCNA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. (PubMed id 2263489)1, 2, 3 Philipson L.H.... Steiner D.F. (Nucleic Acids Res. 1990)
    2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    3. Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. (PubMed id 2001794)1, 2 Tamkun M.M....Glover D.M. (FASEB J. 1991)
    4. Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4--&gt;q14.1. (PubMed id 8449523)1, 9 Philipson L.H....Bell G.I. (Genomics 1993)
    5. Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. (PubMed id 11723117)1, 9 Imamura F....Fujiyoshi Y. (J. Biol. Chem. 2002)
    6. The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene. (PubMed id 1487251)1, 9 Gessler M....Pongs O. (Hum. Genet. 1992)
    7. Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)1, 9 Klocke R....Jockusch H. (Genomics 1993)
    8. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    9. K+ channel alterations in the progression of experimental autoimmune encephalomyelitis. (PubMed id 22560931)1 Jukkola P.I....Gu C. (Neurobiol. Dis. 2012)
    10. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3739 HGNC: 6222 AceView: KCNA4 Ensembl:ENSG00000182255 euGenes: HUgn3739
    ECgene: KCNA4 H-InvDB: KCNA4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCNA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNA4 gene:
    Search GeneIP for patents involving KCNA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA4
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCNA4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNA4   OriGene Custom Protein Services for KCNA4  

     
     
     Block miRNA regulation of human, mouse, rat KCNA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNA4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNA4 Predesigned siRNA for gene silencing in human, mouse, rat KCNA4
     QuantiFast Probe-based Assays in human, mouse, rat KCNA4 QuantiTect SYBR Green Assays in human, mouse, rat KCNA4
     Custom PCR Arrays for KCNA4 Search Chromatin IP Primers for KCNA4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNA4  GeneGlobe Interaction Network for KCNA4
     Regulatory tfbs in KCNA4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCNA4 GenScript cDNA clones with any tag delivered in your preferred vector for KCNA4
     GenScript Custom Assay Services for KCNA4 GenScript Custom overexpressing Cell Line Services for KCNA4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KCNA4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCNA4 antibodies
     KCNA4 proteins
     Antibodies for KCNA4
     See all of Abcam's Antibodies, Kits and Proteins for KCNA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KCNA4
     Antibodies for KCNA4
     ELISAs for KCNA4
     CLIAs for KCNA4



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCNA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA4
     SwitchGear 3'UTR luciferase reporter plasmids for KCNA4
     SwitchGear Promoter luciferase reporter plasmids for KCNA4
     ThermoFisher Antibodies for KCNA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNA4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNA4
     LSBio Antibodies in human, mouse, rat for KCNA4
     Browse compounds at ApexBio
     Search Addgene for plasmids for KCNA4
      Search eBioscience for proteins for KCNA4
      Search eBioscience for elisas for KCNA4
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for KCNA4 (63 products)
     antibodies-online kits for KCNA4 (8 products)
      Search antibodies-online for peptides for KCNA4
     antibodies-online proteins for KCNA4 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNA4 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4