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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA4 Gene

protein-coding   GIFtS: 62
GCID: GC11M030031

potassium voltage-gated channel, shaker-related subfamily,...

(Previous names: potassium voltage-gated channel, shaker-related subfamily,...)
(Previous symbol: KCNA4L)
 Explore 13 diseases affiliated with
KCNA4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNA4    

Aliases
for KCNA4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 41 2     HBK42
HPCN21 2 3     HUKII2
KCNA4L1 2 3     KV1.42
HK11 2     PCN22
Voltage-Gated K(+) Channel HuKII2 3     Cardiac Potassium Channel2
Voltage-Gated Potassium Channel HBK42 3     Fetal Skeletal Muscle Potassium Channel2
Voltage-Gated Potassium Channel HK12 3     Potassium Channel 22
Voltage-Gated Potassium Channel Subunit Kv1.42 3     Potassium Voltage-Gated Channel Subfamily A Member 42
KCNA82 5     Rapidly Inactivating Potassium Channel2
Kv1.41     Shaker-Related Potassium Channel Kv1.42
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4-Like1     Type A Potassium Channel2

External Ids:    HGNC: 62221   Entrez Gene: 37392   Ensembl: ENSG000001822557   OMIM: 1762665   UniProtKB: P224593   

Export aliases for KCNA4 gene to outside databases

Previous GC identifers: GC11M031625 GC11M030806 GC11M030070 GC11M029996 GC11M029988 GC11M029724


Summaries
for KCNA4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNA4:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each
has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of
the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action
potential.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
channel through which potassium ions may pass in accordance with their electrochemical gradient

summary for KCNA4:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA4


Genomic Views
for KCNA4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA4 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   MIF-1   POU3F2   LCR-F1   FOXL1   C/EBPalpha   CHOP-10   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14

KCNA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030031:  view genomic region     (about GC identifiers)

Start:
 30,031,288 bp from pter      End:
 30,038,570 bp from pter
Size:
 7,283 bases      Orientation:
 minus strand

Proteins
for KCNA4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 4  
Size: 653 amino acids; 73257 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with SIGMAR1
(By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNA4: NX_P22459

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22459

    • KCNA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002224.1  
    ENSEMBL proteins: 
     ENSP00000328511  
    Reactome Protein details: P22459
    Human Recombinant Protein Products: 
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    Uscn Proteins for KCNA4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ----
    GO:0008076voltage-gated potassium channel complex IEA--


    KCNA4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNA4

    Protein Domains /
    Families
    for KCNA4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNA4 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR020467 K_chnl_volt-dep_Kv1.4
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P22459

    ProtoNet protein and cluster: P22459

    4 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004051 Kv1.4 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play
    a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily


    Function
    for KCNA4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNA4_HUMAN, P22459
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
    conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
    channel through which potassium ions may pass in accordance with their electrochemical gradient

         Genatlas biochemistry entry for KCNA4:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 4 (mouse Kv1.4 homolog)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA4
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA4 (see all 46):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-301a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KCNA4 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KCNA4
    OriGene siRNA: KCNA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA4

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS2001794
    GO:0005251NOT delayed rectifier potassium channel activity IBA--
    GO:0005267potassium channel activity ----
    GO:0005515protein binding IPI7477295


    KCNA4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNA4:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Kcna4tm1Lndn for KCNA4
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kcna4):
     behavior/neurological  nervous system 

    KCNA4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNA4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNA4
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA4
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNA4
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for KCNA4 (P224592, 3 ENSP000003285114) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783522, 3, ENSP000002938134MINT-1901203 MINT-1900477 I2D: score=9 STRING: ENSP00000293813
    ACTN2P356092, 3, ENSP000003555374MINT-14873 MINT-14874 I2D: score=2 STRING: ENSP00000355537
    SAT1P216732, 3MINT-63562 I2D: score=5 
    NDUFA4L2Q9NRX32, 3, ENSP000003774114MINT-65617 I2D: score=5 STRING: ENSP00000377411
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS2001794
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0071805potassium ion transmembrane transport ----


    KCNA4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNA4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    1 DrugBank Compound for KCNA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arginineamide-- --target--17139284 17016423 10592235

    5 Novoseek chemical compound relationships for KCNA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 76.3 58 20076774 (5), 11598014 (2), 9867876 (2), 19888682 (2) (see all 41)
    4-aminopyridine 49.8 3 7658383 (1), 11743993 (1), 12740404 (1)
    calcium 27.7 7 16837590 (2), 10676964 (1), 11535596 (1), 11165788 (1) (see all 6)
    sodium 17 3 19118105 (1), 16546141 (1)
    dopamine 0 1 15872020 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNA4 

    Transcripts
    for KCNA4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNA4 gene: 
    NM_002233.3  

    Unigene Cluster for KCNA4:

    Potassium voltage-gated channel, shaker-related subfamily, member 4
    Hs.592002  [show with all ESTs]
    Unigene Representative Sequence: NM_002233
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328224(uc001msk.3) ENST00000526518

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA4 (see all 46):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-301a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KCNA4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK313662.1 L02751.1 M55514.1 M60450.1 

    1 DOTS entry:

    DT.306585 

    20 AceView cDNA sequences:

    BX282390 NM_002233 L02751 CF143509 BF223341 M60450 BF196130 BE467209 
    BE467430 BF111147 BE326268 AI733207 AA974913 AI631014 AI694934 AI793138 
    AW275993 M55514 BX952248 AI701825 

    GeneLoc Exon Structure


    Expression
    for KCNA4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCATAATTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNA4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNA4

    SOURCE GeneReport for Unigene cluster: Hs.592002
        SABiosciences Custom PCR Arrays for KCNA4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA4

    Orthologs
    for KCNA4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNA4 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNA41 potassium voltage-gated channel, shaker-related subfamily, more 74(n)
    81.05(a)    		   395721  NM_204899.1  NP_990230.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNA46
    		 --
    		 80(a)
    		 1 ↔ 1
    		 1(59350772-59352760)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3982112 Kv1.4 potassium channel 77.29(n)    AY124705.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kcna41 potassium voltage-gated channel, shaker-related subfamily, more 67.62(n)
    72.18(a)    		   559036  XM_003198956.1  XP_003199004.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sh3 courtship behavior voltage-gated potassium
    channel    		 67(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55F3C.33   -- 30(a)   IV(742316-752934)   --


    ENSEMBL Gene Tree for KCNA4 (if available)
    TreeFam Gene Tree for KCNA4 (if available) 

    Paralogs
    for KCNA4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNA4 gene
    KCNA62  KCNA22  KCNC22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
    KCNA12  KCNC12  KCNC32  KCND32  KCNA32  KCNA102  
    15 SIMAP similar genes for KCNA4 using alignment to 1 protein entry:     KCNA4_HUMAN:
    KCNA7    KCNA1    KCNA10    KCNA2    KCNA6    KCNA3
    KCNA5    KCNB1    KCNB2    KCND1    KCNF1    KCNC1
    KCNC3    KCNS3    KCNC4

    KCNA4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNA4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 NCBI SNPs in KCNA4 are shown (see all 140)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893785501,2
    		--30030850(+) CCTCAC/TGATTT 1 -- ds50010--------
    rs1820575011,2
    		--30031101(+) CTAGCA/GTTTAT 1 -- ds50010--------
    rs771223241,2
    		--30031128(+) AAAAAA/TTTTAA 1 -- ds50010--------
    rs783977741,2
    		F,--30031227(+) GGCAGA/GAGAAT 1 -- ds50013Minor allele frequency- G:0.11WA NA EA 358
    rs802633361,2
    		--30031321(+) CTTTGT/CCAATC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1837729071,2
    		--30031350(+) AGAGGA/CGAGAA 1 -- ut310--------
    rs1485752271,2
    		--30031540(+) GTCCTA/GTTACC 1 -- ut310--------
    rs1881032731,2
    		--30031585(+) ACTTAC/TTCTAT 1 -- ut310--------
    rs1444030961,2
    		--30031616(+) AAGTCC/TTCCCA 1 -- ut310--------
    rs1809424031,2
    		--30031937(+) TTACTA/TCACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNA4 (30031288 - 30038570 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNA4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for KCNA4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNA4 for disorders           About GeneDecksing

    OMIM gene information: 176266    OMIM disorders: --

    13 diseases for KCNA4:    About MalaCards
    myasthenia gravis    episodic ataxia    myasthenia    neuronitis
    down syndrome    nasopharyngitis    thymoma    insulinoma
    parkinson's disease    ataxia    alzheimer's disease    retinitis
    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for KCNA4:
    Thymoma     Myasthenia gravis     Long QT syndrome

    1 Novoseek disease relationship for KCNA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasopharyngeal carcinoma 35.5 2 16142332 (1), 19496992 (1)

    Human Genome Epidemiology (HuGE) Navigator: KCNA4 (2 documents)

    Export disorders for KCNA4 gene to outside databases

    Publications
    for KCNA4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNA4 gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with KCNA4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. (PubMed id 2263489)1, 2, 3 Philipson L.H.... Steiner D.F. (1990)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    3. Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. (PubMed id 2001794)1, 2 Tamkun M.M....Glover D.M. (1991)
    4. Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1. (PubMed id 8449523)1, 9 Philipson L.H....Bell G.I. (1993)
    5. Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. (PubMed id 11723117)1, 9 Imamura F....Fujiyoshi Y. (2002)
    6. The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene. (PubMed id 1487251)1, 9 Gessler M....Pongs O. (1992)
    7. Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)1, 9 Klocke R....Jockusch H. (1993)
    8. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    9. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    10. Episodic ataxia type 1 mutations affect fast inactiva tion of K+ channels by a reduction in either subunit surface expression or affi nity for inactivation domain. (PubMed id 21307345)1 Imbrici P....Pessia M. (2011)

    External Searches for KCNA4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNA4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3739 HGNC: 6222 AceView: KCNA4 Ensembl:ENSG00000182255 euGenes: HUgn3739
    ECgene: KCNA4 H-InvDB: KCNA4

    Other Databases showing KCNA4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNA4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNA4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNA4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNA4 gene:
    Search GeneIP for patents involving KCNA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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