Aliases for KCNA3 Gene
- Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3 2 3
- Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 2 3
- Voltage-Gated Potassium Channel Subunit Kv1.3 3 4
- Voltage-Gated K(+) Channel HuKIII 3 4
- HPCN3 3 4
- HGK5 3 4
- HLK3 3 4
- Potassium Voltage-Gated Channel Subfamily A Member 3 3
External Ids for KCNA3 Gene
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNA3 Gene
KCNA3 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include pancreas adenocarcinoma and autoimmune pancreatitis. Among its related pathways are Transmission across Chemical Synapses and BDNF signaling pathway. GO annotations related to this gene include delayed rectifier potassium channel activity and outward rectifier potassium channel activity. An important paralog of this gene is KCNA10.
UniProtKB/Swiss-Prot for KCNA3 Gene
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.