Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA3 Gene

protein-coding   GIFtS: 63
GCID: GC01M111214

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 31 2     KV1.32
Voltage-Gated K(+) Channel HuKIII2 3     MK32
Voltage-Gated Potassium Channel Subunit Kv1.32 3     PCN32
HGK52 3     Potassium Channel 32
HLK32 3     Potassium Voltage-Gated Channel Subfamily A Member 32
HPCN32 3     Type N Potassium Channel2
HUKIII2     Voltage-Gated Potassium Channel Protein Kv1.32

External Ids:    HGNC: 62211   Entrez Gene: 37382   Ensembl: ENSG000001772727   OMIM: 1762635   UniProtKB: P220013   

Export aliases for KCNA3 gene to outside databases

Previous GC identifers: GC01M111630 GC01M110080 GC01M110316 GC01M110513 GC01M110926 GC01M111015 GC01M109085


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNA3 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve
cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation
and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on
chromosome 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA3 Gene: 
KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3) is a protein-coding gene. Diseases associated with KCNA3 include breast adenocarcinoma, and autoimmune pancreatitis, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include outward rectifier potassium channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient

summary for KCNA3 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA3 gene promoter:
         STAT5B   Nkx2-5   GATA-1   c-Ets-1   E47   PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

KCNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111214:  view genomic region     (about GC identifiers)

Start:
111,214,310 bp from pter      End:
111,217,655 bp from pter
Size:
3,346 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 3  
Size: 575 amino acids; 63842 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity)
Subcellular location: Cell membrane (By similarity); Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-53 is the initiator
Sequence caution: Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA36425.1; Type=Frameshift; Positions=42; Sequence=AAA59457.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAA59457.1; Type=Frameshift; Positions=Several;
Sequence=AAB88073.1; Type=Erroneous initiation; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAC31761.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q5VWN2

Explore the universe of human proteins at neXtProt for KCNA3: NX_P22001

Explore proteomics data for KCNA3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylation promotes the cell surface expression (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22001

  • KCNA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNA3 Protein Expression
    REFSEQ proteins: NP_002223.3  
    ENSEMBL proteins: 
     ENSP00000358784  
    Reactome Protein details: P22001
    Human Recombinant Protein Products for KCNA3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNA3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KCNA3
    GenScript Custom Purified and Recombinant Proteins Services for KCNA3
    Novus Biologicals KCNA3 Protein
    Novus Biologicals KCNA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNA3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0045121membrane raft IEA--

    KCNA3 for ontologies           About GeneDecksing



    KCNA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNA3
    OriGene Custom Antibody Services for KCNA3
    GenScript Custom Superior Antibodies Services for KCNA3
    Novus Biologicals KCNA3 Antibodies
    Abcam antibodies for KCNA3
    Cloud-Clone Corp. Antibodies for KCNA3 
    ThermoFisher Antibodies for KCNA3
    LSBio Antibodies in human, mouse, rat for KCNA3 

    Assay Products for KCNA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNA3 
    Cloud-Clone Corp. CLIAs for KCNA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.3 
    Voltage-gated potassium channels

    5/9 InterPro protein domains (see all 9):
     IPR004050 K_chnl_volt-dep_Kv1.3
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P22001

    ProtoNet protein and cluster: P22001

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004050 Kv1.3 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily


    KCNA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA3_HUMAN, P22001
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient

         Genatlas biochemistry entry for KCNA3:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity TAS1373731
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
    GO:0015271outward rectifier potassium channel activity IEA--
         
    KCNA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNA3:
     Decreased TP53 protein express  Increased cell death in HCC-19 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcna3):
     growth/size  homeostasis/metabolism  muscle  normal 

    KCNA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KCNA3: Kcna3tm1Gvd Kcna3tm1Lys

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNA3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA3:
    hsa-miR-549 hsa-miR-217 hsa-miR-875-3p hsa-miR-4318 hsa-miR-3688-3p hsa-miR-802 hsa-miR-1299 hsa-miR-31*
    SwitchGear 3'UTR luciferase reporter plasmidKCNA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNA3
    Sirion Biotech Customized adenovirus for overexpression of KCNA3

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of KCNA3
    OriGene clones in human, mouse for KCNA3 (see all 8)
    OriGene ORF clones in mouse, rat for KCNA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNA3 (NM_002232)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3
    Sirion Biotech Customized lentivirus for stable overexpression of KCNA3 
                         Customized lentivirus expression plasmids for stable overexpression of KCNA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNA3
    Search LifeMap BioReagents cell lines for KCNA3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    4BDNF signaling pathway
    BDNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNA3
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA3
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 BioSystems Pathway for KCNA3
        BDNF signaling pathway

    3        Reactome Pathways for KCNA3
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for KCNA3 (P220012, 3 ENSP000003587844) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129592, 3, ENSP000003457314MINT-68491 MINT-68490 I2D: score=3 STRING: ENSP00000345731
    KCNA2P163893, ENSP000003145204I2D: score=2 STRING: ENSP00000314520
    BAXQ078123, ENSP000002932884I2D: score=1 STRING: ENSP00000293288
    IL16Q140053, ENSP000003029354I2D: score=1 STRING: ENSP00000302935
    KCNA4P224593, ENSP000003285114I2D: score=1 STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS1373731
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    5 IUPHAR Ligands for KCNA3 (Kv1.3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    margatoxin
    Pore BlockerNone10.3 - 1010961988 8360176
    charybdotoxin
    Pore BlockerNone8.72475579 10961988 1373731
    correolide
    Pore BlockerNone810213593
    noxiustoxin
    InhibitorNone8--
    tetraethylammonium
    InhibitorNone8--

    2 Novoseek inferred chemical compound relationships for KCNA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 67.6 17 12484776 (1), 16124368 (1), 16317062 (1), 18438846 (1) (see all 13)
    charybdotoxin 56.5 2 12833539 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNA3 gene: 
    NM_002232.3  

    Unigene Cluster for KCNA3:

    Potassium voltage-gated channel, shaker-related subfamily, member 3
    Hs.169948  [show with all ESTs]
    Unigene Representative Sequence: NM_002232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369769(uc001dzv.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA3:
    hsa-miR-549 hsa-miR-217 hsa-miR-875-3p hsa-miR-4318 hsa-miR-3688-3p hsa-miR-802 hsa-miR-1299 hsa-miR-31*
    SwitchGear 3'UTR luciferase reporter plasmidKCNA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA3
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNA3 (see all 8)
    OriGene ORF clones in mouse, rat for KCNA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNA3 (NM_002232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3
    Sirion Biotech Customized lentivirus for stable overexpression of KCNA3 
                         Customized lentivirus expression plasmids for stable overexpression of KCNA3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNA3
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA3

    Additional mRNA sequence: 

    AK314009.1 BC035059.1 BC064595.1 L23499.1 

    2 DOTS entries:

    DT.97800327  DT.308260 

    21 AceView cDNA sequences:

    BE935835 AA811374 BC064595 BM128683 BM924998 BM023366 BI547153 CA438434 
    BF954316 L23499 AL133816 BM128211 BC035059 BU678428 CD367215 BV198579 
    BV192657 BF090076 CD694319 BG772202 AI095381 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGCTCAG
    KCNA3 Expression
    About this image


    See KCNA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNA3

    SOURCE GeneReport for Unigene cluster: Hs.169948
        SABiosciences Custom PCR Arrays for KCNA3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNA3
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNA3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna31 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 90.63(n)1
    97.51(a)1
      3 (46.59 cM)5
    164911  NM_008418.21  NP_032444.21 
     1070361625 
    chicken
    (Gallus gallus)
    Aves KCNA31 potassium voltage-gated channel, shaker-related subfamily, more 78.3(n)
    85.27(a)
      404303  NM_001030378.1  NP_001025549.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA36
    potassium voltage-gated channel, shaker-related su...
    74(a)
    1 ↔ 1
    4(106932713-106934512)
    African clawed frog
    (Xenopus laevis)
    Amphibia kcna3b-A-prov2 shaker-like potassium channel subunit Kv1.3B 78.24(n)    AF395810.1 
    zebrafish
    (Danio rerio)
    Actinopterygii --
    KCNA36
    --
    potassium voltage-gated channel, shaker-related su...
    86(a)
    86(a)
    possible ortholog
    1 ↔ 1
    23(5077480-5078928)
    6(49307801-49309252)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel
    70(a)     --


    ENSEMBL Gene Tree for KCNA3 (if available)
    TreeFam Gene Tree for KCNA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNA3 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
    KCNA12  KCNC12  KCNA42  KCNC32  KCND32  KCNA102  
    18/19 SIMAP similar genes for KCNA3 using alignment to 1 protein entry:     KCNA3_HUMAN(see all similar genes):
    KCNA10    KCNA2    KCNA1    KCNA7    KCNA4    KCNA5
    KCNA6    KCNB1    KCND1    KCNC1    KCND3    KCND2
    KCNS1    KCNF1    KCNS2    KCNG3    KCNS3    KCNC4

    KCNA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 SNPs in KCNA3 are shown (see all 99)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882684441,2
    --111213985(+) GCATGC/TAACTA 1 -- ds50010--------
    rs124089171,2
    C,F,H--111214106(+) ATTCTG/ATCTGT 1 -- ds50018Minor allele frequency- A:0.00NS EA NA 702
    rs1434328571,2
    --111214259(+) CTTGTC/TAAGTG 1 -- ds50010--------
    rs1141563871,2
    C,F--111214261(+) TGTCAA/GGTGCT 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1479898671,2
    --111214442(+) AGAAAA/GAAAAC 1 -- ut310--------
    rs2004345461,2
    C--111214551(+) TTCCT-/CCTTGA 1 -- ut310--------
    rs1928167841,2
    --111214676(+) CAGTGA/GTTTTC 1 -- ut310--------
    rs1408646561,2
    --111214719(+) AAAGGC/TTACTG 1 -- ut310--------
    rs1446930471,2
    C--111214944(+) CAGCAA/GCACTG 1 -- ut310--------
    rs1837270401,2
    --111214996(+) ACATAG/TGCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNA3 (111214310 - 111217655 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNA3: --

    Human Gene Mutation Database (HGMD): KCNA3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNA3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176263    OMIM disorders: --

    19 diseases for KCNA3:    About MalaCards
    breast adenocarcinoma    autoimmune pancreatitis    type 1 diabetes mellitus    lung adenocarcinoma
    type 1 diabetes    insulinoma    systemic lupus erythematosus    multiple sclerosis
    diabetes mellitus    lupus erythematosus    adenocarcinoma    alzheimer's disease
    pancreatitis    neuronitis    sarcoma    prostate cancer
    hypoxia    prostatitis    breast cancer


    KCNA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): KCNA3
    Human Genome Epidemiology (HuGE) Navigator: KCNA3 (2 documents)

    Export disorders for KCNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNA3 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with KCNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PubMed id 16317062)1, 4, 9 Tschritter O....Fritsche A. (2006)
    2. Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PubMed id 7829094)1, 2, 9 Folander K.... Swanson R. (1994)
    3. Effect of genetic variation in Kv1.3 on olfactory fun ction. (PubMed id 19489042)1, 4 Guthoff M....Fritsche A. (2009)
    4. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. (PubMed id 1373731)1, 2 Attali B.... Lazdunski M. (1992)
    7. Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. (PubMed id 1547020)1, 2 Cai Y.-C.... Douglass J. (1992)
    8. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PubMed id 1986382)1, 2 Philipson L.H.... Steiner D.F. (1991)
    9. Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)1, 3 Grissmer S....Chandy K.G. (1990)
    10. Crystallization and preliminary X-ray diffraction stu dies of the tetramerization domain derived from the human potassium channel Kv1 .3. (PubMed id 19574640)1, 9 Winklmeier A....Kremer W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3738 HGNC: 6221 AceView: KCNA3 Ensembl:ENSG00000177272 euGenes: HUgn3738
    ECgene: KCNA3 H-InvDB: KCNA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNA3 gene:
    Search GeneIP for patents involving KCNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Clones for the Expression of KCNA3
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA3
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNA3   OriGene RNAi products in human, mouse, rat for KCNA3  
     OriGene qPCR primer pairs and template standards for KCNA3   OriGene Protein Over-expression Lysate for KCNA3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNA3   OriGene Custom Protein Services for KCNA3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNA3
     QIAGEN SeqTarget long-range PCR primers for resequencing KCNA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA3
     GenScript Custom Purified and Recombinant Proteins Services for KCNA3 GenScript cDNA clones with any tag delivered in your preferred vector for KCNA3
     GenScript Custom Assay Services for KCNA3 GenScript Custom Superior Antibodies Services for KCNA3
     GenScript Custom overexpressing Cell Line Services for KCNA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNA3 promoter
     Search Chromatin IP Primers for KCNA3
     RT2 qPCR Primer Assay in human, mouse, rat KCNA3
     GNC Network for KCNA3
     SABiosciences PCR Arrays including human, mouse, rat KCNA3
     Tocris compounds for KCNA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNA3 antibodies
     KCNA3 proteins
     KCNA3 lysates
     Antibodies for KCNA3
     See all of Abcam's Antibodies, Kits and Proteins for KCNA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KCNA3
     Antibodies for KCNA3
     ELISAs for KCNA3
     CLIAs for KCNA3
     Search LifeMap BioReagents cell lines for KCNA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3
     SwitchGear 3'UTR luciferase reporter plasmids for KCNA3
     SwitchGear Promoter luciferase reporter plasmids for KCNA3
     ThermoFisher Antibodies for KCNA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNA3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNA3
    Customized:
     lentivirus for stable overexpression of KCNA3
     lentivirus expression plasmids for stable overexpression of KCNA3
     adenovirus for overexpression of KCNA3
     LSBio Antibodies in human, mouse, rat for KCNA3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNA3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4