KCNA3 Gene
protein-coding GIFtS: 62
GCID: GC01M111214
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|
potassium voltage-gated channel, shaker-related subfamily,...
| |
Aliases
for KCNA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 31 2 | | HUKIII2 | | HLK31 2 3 | | KV1.32 | | HPCN31 2 3 | | PCN32 | | MK31 2 | | Potassium Channel 32 | | Voltage-Gated K(+) Channel HuKIII2 3 | | Potassium Voltage-Gated Channel Subfamily A Member 32 | | Voltage-Gated Potassium Channel Subunit Kv1.32 3 | | Type N Potassium Channel2 | | HGK52 3 | | Voltage-Gated Potassium Channel Protein Kv1.32 | | Kv1.31 | | |
Export aliases for KCNA3 gene to outside databasesPrevious GC identifers: GC01M111630 GC01M110080 GC01M110316 GC01M110513 GC01M110926 GC01M111015 GC01M109085 |
Summaries
for KCNA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNA3:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structuralstandpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Foursequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and eachhas been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourthsegment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarizefollowing an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears tobe intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closedconformations in response to the voltage difference across the membrane, the protein forms a potassium-selectivechannel through which potassium ions may pass in accordance with their electrochemical gradient
 summary
for KCNA3:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNA3
|
Genomic Views
for KCNA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNA3 gene promoter:
STAT5B Nkx2-5 GATA-1 c-Ets-1 E47 PPAR-gamma1 POU2F1 POU2F1a FOXO4 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3KCNA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M111214: view genomic region
(about GC identifiers)
Start:
|
111,214,310 bp from pter |
End:
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111,217,655 bp from pter |
Size:
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3,346 bases |
Orientation:
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minus strand |
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Proteins
for KCNA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily A member 3 Size: 575 amino acids; 63842 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity)
Subcellular location: Cell membrane (By similarity); Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-53 is the initiator
Sequence caution: Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAA36425.1; Type=Frameshift; Positions=42; Sequence=AAA59457.1; Type=Erroneous initiation; Note=TranslationN-terminally extended; Sequence=AAA59457.1; Type=Frameshift; Positions=Several; Sequence=AAB88073.1; Type=Erroneousinitiation; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAC31761.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q5VWN2Explore the universe of human proteins at neXtProt for KCNA3: NX_P22001
Post-translational modifications:
N-glycosylation promotes the cell surface expression (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P22001
KCNA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002223.3
ENSEMBL proteins: ENSP00000358784 Reactome Protein details: P22001
Human Recombinant Protein Products for KCNA3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0045121 | membrane raft |
IEA | -- |
KCNA3 for ontologies About GeneDecksing
KCNA3 Antibody Products:
Assay Products for KCNA3: |
Protein
Domains /
Families
for KCNA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNA3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P22001ProtoNet protein and cluster: P22001 4 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003972 Skaker voltage-gated K+ channel family signature IPB004050 Kv1.3 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may playa role in modulation of channel activity and/or targeting of the channel to specific subcellular compartmentsDomain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third positionSimilarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily |
Function
for KCNA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCNA3_HUMAN, P22001Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closedconformations in response to the voltage difference across the membrane, the protein forms a potassium-selectivechannel through which potassium ions may pass in accordance with their electrochemical gradient Genatlas biochemistry entry for KCNA3:potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
TAS | 1373731 | | GO:0005251 | delayed rectifier potassium channel activity |
IBA | -- | | GO:0015271 | outward rectifier potassium channel activity |
IEA | -- |
KCNA3 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for KCNA3:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kcna3):
KCNA3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for KCNA3: Kcna3tm1Gvd Kcna3tm1Lys
Clone
Products: |  | EMD Millipore Clones for the Expression of KCNA3 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCNA3 (NM_002232) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3 |
|
Pathways & Interactions
for KCNA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 3 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KCNA3
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA3
3 
Reactome Pathways for KCNA3
KCNA3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for KCNA3 (P220012, 3 ENSP000003587844) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
KCNA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNA3 for compounds About GeneDecksing
Compounds for KCNA3 available from Tocris Bioscience About this table
1 HMDB Compound for KCNA3 About this table
2 Novoseek chemical compound relationships for KCNA3 gene About this table
Search CenterWatch for drugs/clinical trials and news about KCNA3
|
Transcripts
for KCNA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNA3 gene: NM_002232.3 Unigene Cluster for KCNA3: Potassium voltage-gated channel, shaker-related subfamily, member 3 Hs.169948 [show with all ESTs]Unigene Representative Sequence: NM_0022321 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369769(uc001dzv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCNA3 (NM_002232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3 |
Additional cDNA sequence: AK314009.1 BC035059.1 BC064595.1 L23499.1 2 DOTS entries: DT.97800327 DT.308260 21 AceView cDNA sequences: AA811374 BM128683 BC064595 BE935835 BM023366 AL133816 BM924998 CD367215 BM128211 BC035059 BU678428 CA438434 L23499 BI547153 BF954316 BV198579 BV192657 BF090076 CD694319 BG772202 AI095381
GeneLoc Exon Structure
|
Expression
for KCNA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGCTCAG
About this image
See KCNA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNA3
SOURCE GeneReport for Unigene cluster: Hs.169948
SABiosciences Custom PCR Arrays for KCNA3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3 |
Orthologs
for KCNA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNA3 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNA31 |
potassium voltage-gated channel, shaker-related subfamily, more |
78.3(n)
85.27(a) |
|
404303 NM_001030378.1 NP_001025549.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KCNA36 |
-- |
82(a) |
1 ↔ 1 |
4(106932713-106934801) |
African clawed frog
(Xenopus laevis) |
Amphibia |
kcna3b-A-prov2 |
shaker-like potassium channel subunit Kv1.3B |
78.24(n) |
|
AF395810.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01079211.16CABZ01070380.16 |
-- |
85(a)85(a) |
1 ↔ 1possible ortholog |
6(49307801-49309252) 23(5077480-5078928) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sh3 |
courtship behavior voltage-gated potassium
channel |
70(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y55F3C.33 |
-- |
30(a) |
|
IV(742316-752934) -- |
ENSEMBL Gene Tree for KCNA3 (if available)
TreeFam Gene Tree for KCNA3 (if available) |
Paralogs
for KCNA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNA3 gene
- KCNA62 KCNA22 KCNC22 KCNC42 KCND22 KCND12 KCNA72 KCNA52
- KCNA12 KCNC12 KCNA42 KCNC32 KCND32 KCNA102
18/19 SIMAP similar genes for KCNA3 using alignment to 1 protein entry: KCNA3_HUMAN(see all similar genes):KCNA10 KCNA2 KCNA1 KCNA7 KCNA4 KCNA5
KCNA6 KCNB1 KCND1 KCNC1 KCND3 KCND2
KCNS1 KCNF1 KCNS2 KCNG3 KCNS3 KCNC4
KCNA3 for paralogs About GeneDecksing
|
Genomic Variants
for KCNA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNA3 (111214310 - 111217655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNA3: --
Human Gene Mutation Database (HGMD): KCNA3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNA3 |
|
Disorders
/ Diseases
for KCNA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNA3 for disorders About GeneDecksing
OMIM gene information: 176263
OMIM disorders: --
17  diseases for KCNA3: About MalaCardstype 1 diabetes mellitus systemic lupus erythematosus lupus erythematosus diabetes mellitus
neuronitis autoimmune pancreatitis multiple sclerosis insulinoma
lung adenocarcinoma breast adenocarcinoma adenocarcinoma alzheimer's disease
prostate cancer breast cancer pancreatitis cholesterol
prostatitis
Genetic Association Database (GAD): KCNA3
Human Genome Epidemiology (HuGE) Navigator: KCNA3 (2 documents)
Export disorders for KCNA3 gene to outside databases
|
Publications
for KCNA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNA3 gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with KCNA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PubMed id 16317062)1, 4, 9 Tschritter O....Fritsche A. (2006)
- Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PubMed id 7829094)1, 2, 9 Folander K.... Swanson R. (1994)
- International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. (PubMed id 1373731)1, 2 Attali B.... Lazdunski M. (1992)
- Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. (PubMed id 1547020)1, 2 Cai Y.-C.... Douglass J. (1992)
- Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PubMed id 1986382)1, 2 Philipson L.H.... Steiner D.F. (1991)
- Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)1, 3 Grissmer S....Chandy K.G. (1990)
- Crystallization and preliminary X-ray diffraction stu dies of the tetramerization domain derived from the human potassium channel Kv1 .3. (PubMed id 19574640)1, 9 Winklmeier A....Kremer W. (2009)
- Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PubMed id 17242956)1, 9 Pottosin I.I....Dobrovinskaya O.R. (2007)
|
External Searches for KCNA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNA3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNA3 gene:
Search GeneIP for patents involving KCNA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for KCNA3 | | OriGene shRNA RFP for KCNA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNA3 | | | OriGene Protein Over-expression Lysate for KCNA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNA3 | | OriGene 3'-UTR Clone for KCNA3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNA3 | | OriGene Custom Protein Services for KCNA3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA3 |
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| | | | Tocris compounds for KCNA3 |
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 | | | KCNA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3 |
|  |  |  |  | | | | ThermoFisher Antibodies for KCNA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA3 |
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