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KCNA3 Gene

protein-coding   GIFtS: 63
GCID: GC01M111214

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

  See KCNA3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 31 2     KV1.32
Voltage-Gated K(+) Channel HuKIII2 3     MK32
Voltage-Gated Potassium Channel Subunit Kv1.32 3     PCN32
HGK52 3     Potassium Channel 32
HLK32 3     Potassium Voltage-Gated Channel Subfamily A Member 32
HPCN32 3     Type N Potassium Channel2
HUKIII2     Voltage-Gated Potassium Channel Protein Kv1.32

External Ids:    HGNC: 62211   Entrez Gene: 37382   Ensembl: ENSG000001772727   OMIM: 1762635   UniProtKB: P220013   

Export aliases for KCNA3 gene to outside databases

Previous GC identifers: GC01M111630 GC01M110080 GC01M110316 GC01M110513 GC01M110926 GC01M111015 GC01M109085


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNA3 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve
cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation
and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on
chromosome 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA3 Gene:
KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3) is a protein-coding gene. Diseases associated with KCNA3 include pancreas adenocarcinoma, and autoimmune pancreatitis. GO annotations related to this gene include outward rectifier potassium channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient

summary for KCNA3 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNA3 gene promoter:
         STAT5B   Nkx2-5   GATA-1   c-Ets-1   E47   PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA3 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

KCNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111214:  view genomic region     (about GC identifiers)

Start:
111,214,310 bp from pter      End:
111,217,655 bp from pter
Size:
3,346 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 3  
Size: 575 amino acids; 63842 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity)
Caution: It is uncertain whether Met-1 or Met-53 is the initiator
Sequence caution: Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA36425.1; Type=Frameshift; Positions=42; Sequence=AAA59457.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAA59457.1; Type=Frameshift; Positions=Several;
Sequence=AAB88073.1; Type=Erroneous initiation; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAC31761.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for KCNA3:
4BGC (3D)    
Secondary accessions: Q5VWN2

Explore the universe of human proteins at neXtProt for KCNA3: NX_P22001

Explore proteomics data for KCNA3 at MOPED

Post-translational modifications: 

  • N-glycosylation promotes the cell surface expression (By similarity)1
  • Ubiquitination2 at Lys120, Lys526
  • Glycosylation2 at Asn279
  • Modification sites at PhosphoSitePlus

  • See KCNA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002223.3  
    ENSEMBL proteins: 
     ENSP00000358784  
    Reactome Protein details: P22001

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.3
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 10):
     IPR004050 K_chnl_volt-dep_Kv1.3
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1

    Graphical View of Domain Structure for InterPro Entry P22001

    ProtoNet protein and cluster: P22001

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004050 Kv1.3 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily


    Find genes that share domains with KCNA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA3_HUMAN, P22001
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient

         Genatlas biochemistry entry for KCNA3:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity TAS1373731
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
    GO:0015271outward rectifier potassium channel activity IEA--
         
    Find genes that share ontologies with KCNA3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNA3:
     Decreased TP53 protein express  Increased cell death in HCC-19 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcna3):
     growth/size/body  homeostasis/metabolism  muscle  normal 

    Find genes that share phenotypes with KCNA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNA3: Kcna3tm1Gvd Kcna3tm1Lys

       genOway: Develop your customized and physiologically relevant rodent model for KCNA3

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    SwitchGear 3'UTR luciferase reporter plasmidKCNA3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNA3_HUMAN, P22001: Cell membrane (By similarity); Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0045121membrane raft IEA--

    Find genes that share ontologies with KCNA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    4BDNF signaling pathway
    BDNF signaling pathway


    Find genes that share SuperPaths with KCNA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNA3
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 BioSystems Pathway for KCNA3
        BDNF signaling pathway

    1 Reactome Pathway for KCNA3
        Voltage gated Potassium channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNA3
    Interactions:

        GeneGlobe Interaction Network for KCNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNA3 (P220012, 3 ENSP000003587844) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129592, 3, ENSP000003457314MINT-68491 MINT-68490 I2D: score=3 STRING: ENSP00000345731
    KCNA2P163893, ENSP000003145204I2D: score=2 STRING: ENSP00000314520
    BAXQ078123, ENSP000002932884I2D: score=1 STRING: ENSP00000293288
    IL16Q140053, ENSP000003029354I2D: score=1 STRING: ENSP00000302935
    KCNA4P224593, ENSP000003285114I2D: score=1 STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS1373731
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with KCNA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    5 IUPHAR Ligands for KCNA3 (Kv1.3)    About this table
    LigandTypeActionAffinityPubmed IDs
    margatoxin
    Pore BlockerNone10.3 - 1010961988 8360176
    charybdotoxin
    Pore BlockerNone8.72475579 10961988 1373731
    correolide
    Pore BlockerNone810213593
    noxiustoxin
    InhibitorNone8--
    tetraethylammonium
    InhibitorNone8--

    2 Novoseek inferred chemical compound relationships for KCNA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 67.6 17 12484776 (1), 16124368 (1), 16317062 (1), 18438846 (1) (see all 13)
    charybdotoxin 56.5 2 12833539 (1)



    Find genes that share compounds with KCNA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNA3 gene: 
    NM_002232.4  

    Unigene Cluster for KCNA3:

    Potassium voltage-gated channel, shaker-related subfamily, member 3
    Hs.169948  [show with all ESTs]
    Unigene Representative Sequence: NM_002232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369769(uc001dzv.1)
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    Additional mRNA sequence: 

    AK314009.1 BC035059.1 BC064595.1 L23499.1 

    2 DOTS entries:

    DT.97800327  DT.308260 

    21 AceView cDNA sequences:

    AA811374 BM128683 BC064595 BE935835 BC035059 L23499 BM128211 CD367215 
    BU678428 BF954316 AL133816 BM924998 CA438434 BI547153 BM023366 BF090076 
    BV198579 BV192657 CD694319 BG772202 AI095381 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGCTCAG
    KCNA3 Expression
    About this image

    KCNA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169948
        Custom PCR Arrays for KCNA3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNA3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna31 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 89.74(n)1
    96.18(a)1
      3 (46.59 cM)5
    164911  NM_008418.21  NP_032444.21 
     1070361625 
    chicken
    (Gallus gallus)
    Aves KCNA31 potassium voltage-gated channel, shaker-related subfamily, more 76.26(n)
    83.63(a)
      404303  NM_001030378.1  NP_001025549.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA36
    potassium voltage-gated channel, shaker-related su...
    76(a)
    1 ↔ 1
    4(106932713-106934512)
    African clawed frog
    (Xenopus laevis)
    Amphibia kcna3b-A-prov2 shaker-like potassium channel subunit Kv1.3B 78.24(n)    AF395810.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003302831 potassium voltage-gated channel subfamily A member more 73.41(n)
    84.05(a)
      100330283  XM_005174099.1  XP_005174156.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh1 , 3 courtship behavior voltage-gated
    potassium channel3
    Shaker1
    70(a)3
    60.57(n)1
    73.15(a)1
      327801  NM_078669.51  NP_523393.31 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3C.33
    shk-11
    shk-11 30(a)3
    53.35(n)1
    50.13(a)1
      IV(742316-752934)3
    1745361  NM_063703.41  NP_496104.21 


    ENSEMBL Gene Tree for KCNA3 (if available)
    TreeFam Gene Tree for KCNA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNA3 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
    KCNA12  KCNC12  KCNA42  KCNC32  KCND32  KCNA102  
    Selected SIMAP similar genes for KCNA3 using alignment to 1 protein entry:     KCNA3_HUMAN(see all similar genes):
    KCNA10    KCNA2    KCNA1    KCNA7    KCNA4    KCNA5
    KCNA6    KCNB1    KCND1    KCNC1    KCND3    KCND2
    KCNS1    KCNF1    KCNS2    KCNG3    KCNS3    KCNC4

    Find genes that share paralogs with KCNA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNA3 (see all 99)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882684441,2
    --111213985(+) GCATGC/TAACTA 1 -- ds50010--------
    rs124089171,2
    C,F,H--111214106(+) ATTCTG/ATCTGT 1 -- ds50018Minor allele frequency- A:0.00NS EA NA 702
    rs1434328571,2
    --111214259(+) CTTGTC/TAAGTG 1 -- ds50010--------
    rs1141563871,2
    C,F--111214261(+) TGTCAA/GGTGCT 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1479898671,2
    --111214442(+) AGAAAA/GAAAAC 1 -- ut310--------
    rs2004345461,2
    C--111214551(+) TTCCT-/CCTTGA 1 -- ut310--------
    rs1928167841,2
    --111214676(+) CAGTGA/GTTTTC 1 -- ut310--------
    rs1408646561,2
    --111214719(+) AAAGGC/TTACTG 1 -- ut310--------
    rs1446930471,2
    C--111214944(+) CAGCAA/GCACTG 1 -- ut310--------
    rs1837270401,2
    --111214996(+) ACATAG/TGCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNA3 (111214310 - 111217655 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNA3: --
    Human Gene Mutation Database (HGMD): KCNA3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNA3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176263    OMIM disorders: --

    4 diseases for KCNA3:    
    About MalaCards
    pancreas adenocarcinoma    autoimmune pancreatitis    breast adenocarcinoma    type 1 diabetes mellitus


    Find genes that share disorders with KCNA3           About GenesLikeMe

    Genetic Association Database (GAD): KCNA3
    Human Genome Epidemiology (HuGE) Navigator: KCNA3 (2 documents)

    Export disorders for KCNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNA3 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with KCNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PubMed id 16317062)1, 4, 9 Tschritter O....Fritsche A. (J. Clin. Endocrinol. Metab. 2006)
    2. Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PubMed id 7829094)1, 2, 9 Folander K.... Swanson R. (Genomics 1994)
    3. Effect of genetic variation in Kv1.3 on olfactory function. (PubMed id 19489042)1, 4 Guthoff M....Fritsche A. (Diabetes Metab. Res. Rev. 2009)
    4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. (PubMed id 1373731)1, 2 Attali B.... Lazdunski M. (J. Biol. Chem. 1992)
    7. Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. (PubMed id 1547020)1, 2 Cai Y.-C.... Douglass J. (DNA Cell Biol. 1992)
    8. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PubMed id 1986382)1, 2 Philipson L.H.... Steiner D.F. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    9. Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)1, 3 Grissmer S....Chandy K.G. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    10. Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. (PubMed id 19574640)1, 9 Winklmeier A....Kremer W. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3738 HGNC: 6221 AceView: KCNA3 Ensembl:ENSG00000177272 euGenes: HUgn3738
    ECgene: KCNA3 H-InvDB: KCNA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNA3 gene:
    Search GeneIP for patents involving KCNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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