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KCNA3 Gene

protein-coding GIFtS: 66

GC01M111015

potassium voltage-gated channel, shaker-related subfamily, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HGK5 ^², ³
HLK3 ^¹, ², ³
HPCN3 ^¹, ², ³
HUKIII ^²
HuKIII ^³
KV1.3 ^²
Kv1.3 ^¹
MK3 ^¹, ²
OTTHUMP00000032397 ^²
PCN3 ^²

Descriptions
Voltage-gated potassium channel subunit Kv1.3 ^³
potassium channel 3 ^²
potassium voltage-gated channel, shaker-related subfamily, member 3 ^²
type n potassium channel ^²
voltage-gated potassium channel protein Kv1.3 ^²

External Ids
HGNC: 6221¹
Entrez Gene: 3738²
UniProtKB: P22001³
Ensembl: ENSG00000177272⁷

Search outside databases for aliases for KCNA3 gene

Previous GC identifers: GC01M111630 GC01M110080 GC01M110316 GC01M110513 GC01M110926

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNA3:

Potassium channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter

release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport,

smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes -

shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have

human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,

shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type

repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow

nerve cells to efficiently repolarize following an action potential. It plays an essential role in

T-cell proliferation and activation. This gene appears to be intronless and it is clustered

together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNA3 gene

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3

KCNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M111015: (about GC identifiers)

Start:	111,015,833 bp from pter
End:	111,019,178 bp from pter
Size:	3,346 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily A member 3

Size: 575 amino acids; 63842 Da

Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By

similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Caution: It is uncertain whether Met-1 or Met-53 is the initiator

Sequence caution: Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=AAA36425.1; Type=Frameshift; Positions=42; Sequence=AAA59457.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=AAA59457.1; Type=Frameshift;

Positions=Several; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=AAC31761.1; Type=Frameshift; Positions=Several;

Secondary accessions: Q5VWN2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002223.3

ENSEMBL proteins:

ENSP00000358784

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNA3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNA3)
	Human Recombinant Proteins from Abnova (KCNA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	1373731
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for KCNA3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNA3
	Sigma-Aldrich Antibodies for KCNA3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNA3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNA3)
	Novus Biologicals Antibody for KCNA3

Assays for KCNA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22001

ProtoNet protein and cluster: P22001

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003972 Skaker voltage-gated K+ channel family signature

IPB004050 Kv1.3 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001

Domain: The N-terminus may be important in determining the rate of inactivation of the channel

while the tail may play a role in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. A (Shaker) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002232

Applied Biosystems Silencer® siRNAs for KCNA3

Sigma-Aldrich siRNA and siRNA Panels for KCNA3

Sigma-Aldrich shRNA Panels and shRNA for KCNA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNA3
		Millipore Clones for the Expression of KCNA3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002232
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002232
untagged cDNA clones in CMV expression vector (see all 2): NM_002232

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002232

UniProtKB/Swiss-Prot: KCNA3_HUMAN, P22001

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNA3:

potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3

homolog)

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcna3):

growth/size

homeostasis/metabolism

muscle

normal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	TAS	1373731
GO:0005251	delayed rectifier potassium channel activity	TAS	1986382
GO:0005515	protein binding	IEA	--
GO:0015271	outward rectifier potassium channel activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNA3

5/52 Interacting proteins for KCNA3 (ENSP00000358784³ P22001²) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG1	Q12959²	STRING (score=.921) MINT-68491 MINT-68490
KCNA2	ENSP00000314520³	STRING (score=.987)
KCNH2	ENSP00000262186³	STRING (score=.987)
KCNJ1	ENSP00000316136³	STRING (score=.972)
KCNE1	ENSP00000337255³	STRING (score=.965)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	1373731

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNA3

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNA3 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
CP 339818 hydrochloride	Non-peptide, potent KV1.3 channel blocker	[185855-91-8]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

2 Novoseek chemical compound relationships for KCNA3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	66.43	15	12484776 (1), 16124368 (1), 16317062 (1), 18438846 (1) (see all 11)
charybdotoxin	58.30	2	12833539 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002232

Sigma-Aldrich siRNA and siRNA Panels for KCNA3

Sigma-Aldrich shRNA Panels and shRNA for KCNA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002232

REFSEQ mRNAs for KCNA3 gene:

NM_002232.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002232

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002232
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002232
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002232

Additional cDNA sequence:

AK314009.1 BC035059.1 BC064595.1 L23499.1

2 DOTS entries:

DT.97800327 DT.308260

21 AceView cDNA sequences:

AA811374 BC064595 BE935835 BM128683 CA438434 L23499 BM924998 CD367215

BC035059 BI547153 BF954316 BU678428 BM023366 BM128211 AL133816 BV198579

BF090076 BV192657 CD694319 BG772202 AI095381

highest scoring ESTs for KCNA3:

BC035059 BC064595 BE935835 BF090076 BF954316 BG772202 BM128211 BM128683 BM924998 BU678428

Unigene Cluster for KCNA3:

Potassium voltage-gated channel, shaker-related subfamily, member 3

Hs.169948 [show with all ESTs]

Unigene Representative Sequence: NM_002232

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000369769

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNA3

¹ / ² / ³

3 probe-sets matching KCNA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32277_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M85217	0.60	1.00	0.82	1
207237_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002232	0.40	1.00	0.76	1
207237_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTGCTCAG

SOURCE GeneReport for Unigene cluster: Hs.169948
Expression variation in blood from EXPOLDB for KCNA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNA3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	KCNA3¹	--	potassium voltage-gated channel, shaker-related subfamily, more	99.59(n) 99.3(a)	469412 XM_524797.2 XP_524797.1
cow (Bos taurus)	LOC525507¹	--	similar to potassium voltage-gated channel, shaker-related more	92.29(n) 95.48(a)	525507 XM_603860.3 XP_603860.2
rat (Rattus norvegicus)	Kcna3¹	--	potassium voltage-gated channel, shaker-related subfamily, more	90.89(n) 97.13(a)	29731 NM_019270.2 NP_062143.2
mouse (Mus musculus)	Kcna3^{1, 5}	3 (52.30 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	90.5(n)¹ 97.13(a)¹	16491¹ NM_008418.1¹ NP_032444.1¹ AV478972⁵ BC132349⁵ (see all 8)
chicken (Gallus gallus)	KCNA3¹	--	potassium voltage-gated channel, shaker-related subfamily, more	78.3(n) 85.27(a)	404303 NM_001030378.1 NP_001025549.1

About this table Species with no ortholog for KCNA3

ENSEMBL Gene Tree for KCNA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNA3 gene

KCNA6² KCNA1² KCNA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/22 NCBI SNPs in KCNA3 are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs2821557^1,2	A,C,F,H	111020443(+)	`GCCAAC/TTTATA`	1	--	ng3¹		8		EA NA EU WA	636
	rs1058184^1,2	A,C,F,H	111016995(-)	`TCTCTG/TAACAT`	1	--	ut3¹ trp³		8		EU EA WA NA	772
	rs3762379^1,2	C,F,H	111020867(-)	`ATATAC/TGCAAA`	1	--	ng3¹		12		EA NA EU WA	2456
	rs2840381^1,2	A,C,F	111019346(-)	`CTCCCT/CGTGGG`	1	--	ng3¹		3		NA	142
	rs12752325^1,2	A,H	111020602(+)	`TCCTAG/AGATGA`	1	--	ng3¹		2		EU WA	202
	rs12408917^1,2	C,H	111015629(+)	`ATTCTG/ATCTGT`	1	--	ng5¹		4		EU EA WA	420
--	rs3215042^1,2	C	111016613(-)	`TGCCC-/CCAAGAT`	1	--	ut3¹		0	--	--	--	--
--	rs41281374^1,2	--	111017392(+)	`GTCGAC/GTTACT`	1	N/K	mis¹		0	--	--	--	--
--	rs35618043^1,2	--	111015823(+)	`GTATT-/TTTTTT`	1	--	ng5¹		0	--	--	--	--
--	rs34775318^1,2	--	111015821(+)	`CTGTA-/TTTTTT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KCNA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176263

Human Gene Mutation Database: KCNA3
Genetic Association Database: KCNA3
Human Genome Epidemiology Navigator: KCNA3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/45 PubMed articles for KCNA3 gene (see all 45 ):

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PubMed id 16317062)^{1, 3, 6} Tschritter O....Fritsche A. (2006)
Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PubMed id 7829094)^{1, 3, 4} Folander K.... Swanson R. (1994)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. (PubMed id 1373731)^{3, 4} Attali B.... Lazdunski M. (1992)
Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. (PubMed id 1547020)^{3, 4} Cai Y.-C.... Douglass J. (1992)
Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (PubMed id 1986382)^{3, 4} Philipson L.H.... Steiner D.F. (1991)
Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)^{2, 3} Grissmer S....Chandy K.G. (1990)
Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PubMed id 17242956)^{1, 3} Pottosin I.I....Dobrovinskaya O.R. (2007)
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. (PubMed id 18818304)³ Szabo I....Gulbins E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3738	HGNC: 6221	AceView: KCNA3	Ensembl:ENSG00000177272	euGenes: HUgn3738
ECgene: KCNA3	H-InvDB: KCNA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNA3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNA3		Antibodies for KCNA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNA3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KCNA3)
	Antibodies (KCNA3)
	Chimera RNAi (KCNA3)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for KCNA3

Tocris compounds for KCNA3

	Drugs for KCNA3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KCNA3

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KCNA3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for KCNA3

Summaries
for KCNA3

Genomic Location
for KCNA3

Proteins
for KCNA3

Protein Domains/
Families
for KCNA3

Gene Function
for KCNA3

Pathways & Interactions
for KCNA3

Drugs & Compounds
for KCNA3

Transcripts
for KCNA3

Expression
for KCNA3

Orthologs
for KCNA3

Paralogs
for KCNA3

SNPs/Variants
for KCNA3

Disorders & Mutations
for KCNA3

Medical News
for KCNA3

Publications
for KCNA3

Search for KCNA3

Genome Databases showing KCNA3

Other Databases showing KCNA3

Specialized Databases showing KCNA3

Licensable Technologies
for KCNA3

Services
for KCNA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNA3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor KCNA3

Summariesfor KCNA3

Genomic Locationfor KCNA3

Proteinsfor KCNA3

Protein Domains/Familiesfor KCNA3

Gene Functionfor KCNA3

Pathways & Interactionsfor KCNA3

Drugs & Compoundsfor KCNA3

Transcriptsfor KCNA3

Expression for KCNA3

Orthologsfor KCNA3

Paralogsfor KCNA3

SNPs/Variantsfor KCNA3

Disorders & Mutationsfor KCNA3

Medical Newsfor KCNA3

Publicationsfor KCNA3

Search for KCNA3

Genome Databases showing KCNA3

Other Databases showing KCNA3

Specialized Databases showing KCNA3

Licensable Technologiesfor KCNA3

Servicesfor KCNA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNA3

Summaries
for KCNA3

Genomic Location
for KCNA3

Proteins
for KCNA3

Protein Domains/
Families
for KCNA3

Gene Function
for KCNA3

Pathways & Interactions
for KCNA3

Drugs & Compounds
for KCNA3

Transcripts
for KCNA3

Expression
for KCNA3

Orthologs
for KCNA3

Paralogs
for KCNA3

SNPs/Variants
for KCNA3

Disorders & Mutations
for KCNA3

Medical News
for KCNA3

Publications
for KCNA3

Licensable Technologies
for KCNA3

Services
for KCNA3