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Aliases for KCNA3 Gene

Aliases for KCNA3 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 3 2 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.3 3 4
  • Voltage-Gated K(+) Channel HuKIII 3 4
  • HPCN3 3 4
  • HGK5 3 4
  • HLK3 3 4
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3 3
  • Voltage-Gated Potassium Channel Protein Kv1.3 3
  • Type N Potassium Channel 3
  • Potassium Channel 3 3
  • Potassium Channel 2
  • HUKIII 3
  • KV1.3 3
  • PCN3 3
  • MK3 3

External Ids for KCNA3 Gene

Previous GeneCards Identifiers for KCNA3 Gene

  • GC01M111630
  • GC01M110080
  • GC01M110316
  • GC01M110513
  • GC01M110926
  • GC01M111015
  • GC01M111214
  • GC01M109085

Summaries for KCNA3 Gene

Entrez Gene Summary for KCNA3 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA3 Gene

KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Lymph Node Cancer. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNA2.

UniProtKB/Swiss-Prot for KCNA3 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Tocris Summary for KCNA3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA3 Gene

Genomics for KCNA3 Gene

Regulatory Elements for KCNA3 Gene

Enhancers for KCNA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F110667 1.7 FANTOM5 Ensembl ENCODE 20.9 +6.5 6485 1.4 KCNA3 KCNA2 RBM15 GC01M110673 ENSG00000259834
GH01F110618 1.2 FANTOM5 Ensembl ENCODE 18.4 +55.1 55066 2.1 ATF1 PKNOX1 ARNT ZNF2 ZNF766 GLIS2 GATA2 ZNF143 KLF7 NCOA1 KCNA3 GSTM2 ENSG00000258634 KCNA10 PROK1 CD53 KCNA2 RBM15 GC01M110604
GH01F110645 1 FANTOM5 Ensembl ENCODE 13.8 +27.6 27630 4.4 FEZF1 ZNF2 FOS SP3 JUNB REST TSHZ1 ZNF488 ZNF518A ZNF264 NRBF2P3 ENSG00000235005 HIGD1AP12 KCNA3 CD53 ENSG00000258634 CEPT1 ENSG00000243960 DRAM2 LRIF1
GH01F110630 1.5 FANTOM5 Ensembl ENCODE 11.7 +39.3 39333 10.6 HDGF TBL1XR1 WRNIP1 ZBTB40 RAD21 EGR1 SCRT2 ZNF143 ETV6 KLF7 CD53 KCNA3 KCNA2 KCNA10 KCNC4-AS1 LRIF1 RBM15 ENSG00000259834
GH01F110726 1.2 Ensembl ENCODE 11.6 -52.1 -52148 2.0 TBL1XR1 MTA2 HLF ASH2L MAFG TBX21 ZNF316 MAFF NFYB NBN KCNA3 KCNA10 LOC105378901
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KCNA3 on UCSC Golden Path with GeneCards custom track

Promoters for KCNA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542577 1433 4001 HDGF PKNOX1 ZNF766 GLIS2 ZNF143 ZNF263 SP3 JUNB TBX21 NFIL3

Genomic Location for KCNA3 Gene

Chromosome:
1
Start:
110,653,560 bp from pter
End:
110,675,033 bp from pter
Size:
21,474 bases
Orientation:
Minus strand

Genomic View for KCNA3 Gene

Genes around KCNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA3 Gene

Proteins for KCNA3 Gene

  • Protein details for KCNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22001-KCNA3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 3
    Protein Accession:
    P22001
    Secondary Accessions:
    • Q5VWN2

    Protein attributes for KCNA3 Gene

    Size:
    575 amino acids
    Molecular mass:
    63842 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
    SequenceCaution:
    • Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCNA3 Gene

neXtProt entry for KCNA3 Gene

Post-translational modifications for KCNA3 Gene

Other Protein References for KCNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA3 Gene

Domains & Families for KCNA3 Gene

Gene Families for KCNA3 Gene

Suggested Antigen Peptide Sequences for KCNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22001

UniProtKB/Swiss-Prot:

KCNA3_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
genes like me logo Genes that share domains with KCNA3: view

Function for KCNA3 Gene

Molecular function for KCNA3 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)
UniProtKB/Swiss-Prot Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Gene Ontology (GO) - Molecular Function for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA,TAS 1373731
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity IEA --
GO:0015271 outward rectifier potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNA3: view
genes like me logo Genes that share phenotypes with KCNA3: view

Animal Models for KCNA3 Gene

MGI Knock Outs for KCNA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA3 Gene

Localization for KCNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA3 Gene COMPARTMENTS Subcellular localization image for KCNA3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNA3: view

Pathways & Interactions for KCNA3 Gene

genes like me logo Genes that share pathways with KCNA3: view

Pathways by source for KCNA3 Gene

1 BioSystems pathway for KCNA3 Gene
1 Qiagen pathway for KCNA3 Gene

SIGNOR curated interactions for KCNA3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,TAS 1373731
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNA3: view

Drugs & Compounds for KCNA3 Gene

(12) Drugs for KCNA3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Aminopyridine Approved Pharma Pore Blocker, Target, antagonist potassium channel-blocking agent, Non-selective KV channel blocker 68
Potassium Approved Pharma 0
tetraethylammonium Experimental Pharma Inhibitor 1
Charybdotoxin Pharma Pore Blocker, blocker 0
correolide Pharma Pore Blocker 0

(2) Additional Compounds for KCNA3 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
noxiustoxin
Inhibitor
HMR 1556
223749-46-0

(5) Tocris Compounds for KCNA3 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker 504-24-5
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 113559-13-0
HMR 1556 Potent and selective Iks channel blocker 223749-46-0
Linopirdine dihydrochloride KV7 (KCNQ) channel blocker 113168-57-3
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents 122955-13-9

(3) ApexBio Compounds for KCNA3 Gene

Compound Action Cas Number
ADWX 1 Kv1.3 channel blocker,potent and selective
PAP-1 Kv1.3 inhibitor 870653-45-5
Psora 4 Kv1.3 blocker 724709-68-6
genes like me logo Genes that share compounds with KCNA3: view

Drug Products

Transcripts for KCNA3 Gene

mRNA/cDNA for KCNA3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA3 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA3 Gene

No ASD Table

Relevant External Links for KCNA3 Gene

GeneLoc Exon Structure for
KCNA3
ECgene alternative splicing isoforms for
KCNA3

Expression for KCNA3 Gene

mRNA expression in normal human tissues for KCNA3 Gene

mRNA differential expression in normal tissues according to GTEx for KCNA3 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for KCNA3 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCNA3 Gene



Protein tissue co-expression partners for KCNA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNA3 Gene:

KCNA3

SOURCE GeneReport for Unigene cluster for KCNA3 Gene:

Hs.169948
genes like me logo Genes that share expression patterns with KCNA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNA3 Gene

Orthologs for KCNA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA3 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia KCNA3 34 35
  • 92.12 (n)
dog
(Canis familiaris)
Mammalia KCNA3 34 35
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Kcna3 34
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNA3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna3 34 16 35
  • 89.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CKV1.1 35
  • 84 (a)
OneToOne
KCNA3 34
  • 76.26 (n)
lizard
(Anolis carolinensis)
Reptilia KCNA3 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna1 34
  • 75.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia kcna3b-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii KCNA3 (1 of 2) 35
  • 86 (a)
OneToMany
KCNA3 (2 of 2) 35
  • 86 (a)
OneToMany
LOC100330283 34
  • 73.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000254 34
  • 61.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sh 36 34
  • 60.57 (n)
worm
(Caenorhabditis elegans)
Secernentea shk-1 34
  • 53.35 (n)
Y55F3C.3 36
  • 30 (a)
Species where no ortholog for KCNA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA3 Gene

ENSEMBL:
Gene Tree for KCNA3 (if available)
TreeFam:
Gene Tree for KCNA3 (if available)

Paralogs for KCNA3 Gene

(19) SIMAP similar genes for KCNA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA3: view

Variants for KCNA3 Gene

Sequence variations from dbSNP and Humsavar for KCNA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494119 -- 110,653,275(+) CAACA(G/T)TGTAA intron-variant, downstream-variant-500B
rs1058184 -- 110,672,850(-) TCTCT(G/T)AACAT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1058185 -- 110,672,687(-) TCAAT(C/T)CGTAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1058186 -- 110,672,621(-) GGTGT(C/G)CCTAC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs10857831 -- 110,656,107(+) TTAAT(A/G)TGACA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNA3 Gene

Variant ID Type Subtype PubMed ID
nsv1122384 CNV deletion 24896259

Variation tolerance for KCNA3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA3 Gene

Human Gene Mutation Database (HGMD)
KCNA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA3 Gene

Disorders for KCNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymph node cancer
  • lymph node neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search KCNA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNA3

Genetic Association Database (GAD)
KCNA3
Human Genome Epidemiology (HuGE) Navigator
KCNA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA3
genes like me logo Genes that share disorders with KCNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA3 Gene

Publications for KCNA3 Gene

  1. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PMID: 16317062) Tschritter O. … Fritsche A. (J. Clin. Endocrinol. Metab. 2006) 3 22 46 64
  2. Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PMID: 7829094) Folander K. … Swanson R. (Genomics 1994) 3 4 22 64
  3. Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. (PMID: 19574640) Winklmeier A. … Kremer W. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 22 64
  4. Effect of genetic variation in Kv1.3 on olfactory function. (PMID: 19489042) Guthoff M. … Fritsche A. (Diabetes Metab. Res. Rev. 2009) 3 46 64
  5. Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PMID: 17242956) Pottosin I.I. … Dobrovinskaya O.R. (Pflugers Arch. 2007) 3 22 64

Products for KCNA3 Gene

Sources for KCNA3 Gene

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