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KCNA2 Gene

protein-coding GIFtS: 60

GC01M110848

potassium voltage-gated channel, shaker-related subfamily, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HBK5 ^², ³
HK4 ^¹, ²
HUKIV ^², ³
KV1.2 ^²
Kv1.2 ^¹
MGC50217 ^²
MK2 ^²
NGK1 ^², ³
RBK2 ^²

Descriptions
Voltage-gated potassium channel subunit Kv1.2 ^³
potassium channel ^²
potassium voltage-gated channel, shaker-related subfamily, member 2 ^²
voltage-gated potassium channel protein Kv1.2 ^²

External Ids
HGNC: 6220¹
Entrez Gene: 3737²
UniProtKB: P16389³
Ensembl: ENSG00000177301⁷

Search outside databases for aliases for KCNA2 gene

Previous GC identifers: GC01M111562 GC01M110012 GC01M110238 GC01M110434

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNA2:

Potassium channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter

release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport,

smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes -

shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have

human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,

shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type

repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow

nerve cells to efficiently repolarize following an action potential. The coding region of this

gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

[provided by RefSeq]

UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

Gene Wiki entry for KCNA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNA2 gene

Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13

KCNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M110848: (about GC identifiers)

Start:	110,937,728 bp from pter
End:	110,975,619 bp from pter
Size:	37,892 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily A member 2

Size: 499 amino acids; 56717 Da

Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By

similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004965.1

ENSEMBL proteins:

ENSP00000358785 ENSP00000314520

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNA2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNA2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	2251283
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNA2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNA2
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNA2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNA2)
	Novus Biologicals Antibody for KCNA2

Assays for KCNA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P16389

ProtoNet protein and cluster: P16389

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003972 Skaker voltage-gated K+ channel family signature

IPB004049 Kv1.2 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389

Domain: The N-terminus may be important in determining the rate of inactivation of the channel

while the tail may play a role in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. A (Shaker) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC043564

Applied Biosystems Silencer® siRNAs for KCNA2

Sigma-Aldrich siRNA and siRNA Panels for KCNA2

Sigma-Aldrich shRNA Panels and shRNA for KCNA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNA2
		Millipore Clones for the Expression of KCNA2

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004974
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004974
untagged cDNA clones in CMV expression vector (see all 2): BC043564

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004974

UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNA2:

potassium voltage-gated channel,Drosophila shaker-related subfamily,member 2 (mouse Kv1.2

homolog),localized in terminal and juxtaparanodal regions of neurons

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcna2):

behavior/neurological	growth/size	homeostasis/metabolism	lethality-postnatal	nervous system
no phenotypic analysis	respiratory system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005251	delayed rectifier potassium channel activity	TAS	1715584
GO:0005515	protein binding	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for KCNA2

5/67 Interacting proteins for KCNA2 (ENSP00000314520³) via UniProtKB, MINT, and/or STRING (see all 67 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNAB2	ENSP00000367323³	STRING (score=.995)
KCNA3	ENSP00000358784³	STRING (score=.987)
KCNA4	ENSP00000328511³	STRING (score=.987)
KCNH2	ENSP00000262186³	STRING (score=.984)
KCNAB1	ENSP00000305858³	STRING (score=.981)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	2251283

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNA2 available from Tocris Bioscience

Compound	Action	CAS number
Chromanol 293B	IKs blocker. Also blocks ICFTR	[163163-23-3]
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
(-)-[3R,4S]-Chromanol 293B	IKs blocker. Enantiomer of (Cat. No. 1412)	[163163-24-4]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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3 Novoseek chemical compound relationships for KCNA2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	30.71	11	1436093 (2), 10617203 (1), 9875368 (1), 11427541 (1) (see all 7)
phosphatidylinositol	1.66	1	12832460 (1)
lipid	0.00	1	1436093 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC043564

Sigma-Aldrich siRNA and siRNA Panels for KCNA2

Sigma-Aldrich shRNA Panels and shRNA for KCNA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004974

REFSEQ mRNAs for KCNA2 gene:

NM_004974.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004974

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004974
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004974
                                 untagged cDNA clones in CMV expression vector (see all 2): BC043564

Additional cDNA sequence: BC043564.1

3 DOTS entries:

DT.208540 DT.91750614 DT.95301346

7 AceView cDNA sequences:

NM_004974 BI907383 BC043564 BM718279 L02752 BP346542 AW022870

highest scoring ESTs for KCNA2:

BC043564 BI907383 BM718279 BP346542 L02752 NM_004974 AW022870 BM682747 CN288407 DA341137

Unigene Clusters for KCNA2:

Potassium voltage-gated channel, shaker-related subfamily, member 2

Hs.248139 [show with all ESTs], Hs.657199 [show with all ESTs]

Unigene Representative Sequences: AK290061, BC043564

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNA2

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7
SP1:			-		-
SP2:									-
SP3:

About this scheme

ECgene alternative splicing isoforms for KCNA2

2 Ensembl transcripts including schematic representations:

ENST00000369770 ENST00000316361

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNA2

¹ / ² / ³

5 probe-sets matching KCNA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55937_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	H05626	0.40	1.00	0.76	1
208564_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004974	0.60	1.00	0.82	1
239118_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BF513715	0.20	1.00	0.72	1
208564_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239118_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks KCNA2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGTGTACATA

SOURCE GeneReport for Unigene clusters: Hs.248139 Hs.657199

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNA2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNA2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	93.19(n) 98.8(a)	404022 NM_001003329.1 NP_001003329.1
chimpanzee (Pan troglodytes)	KCNA2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	99.8(n) 100(a)	469413 XM_524798.2 XP_524798.2
cow (Bos taurus)	KCNA2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	94.86(n) 100(a)	539608 XM_588328.3 XP_588328.1
rat (Rattus norvegicus)	Kcna2¹	--	potassium voltage-gated channel, shaker-related subfamily, more	94.05(n) 99.4(a)	25468 NM_012970.2 NP_037102.1
mouse (Mus musculus)	Kcna2^{1, 5}	3 (48.80 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	93.72(n)¹ 99.2(a)¹	16490¹ NM_008417.3¹ NP_032443.2¹ AK044342⁵ BC138650⁵ (see all 7)

About this table Species with no ortholog for KCNA2

ENSEMBL Gene Tree for KCNA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNA2 gene

KCNA6² KCNA1² KCNA3²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/17 NCBI SNPs in KCNA2 are shown (see all 17 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3887820^1,2	A,C,F,H	110949603(-)	`CTGTTG/TGTGCA`	1	--	ut5¹		8		EU EA WA NA	780
--	rs3860224^1,2	A,C	110950512(+)	`CGCTCA/CGCCTG`	1	--	ng3¹		0	--	--	--	--
	rs4839536^1,2	H	110947244(+)	`TGTGCC/ATGAAA`	1	--	ng5¹		4		EU EA WA	416
	rs11102136^1,2	A	110950345(+)	`AGTCTC/GCACTG`	1	--	ng3¹		0	--	--	--	--
	rs884482^1,2	F	110950814(-)	`TGGACG/CCCGGG`	1	--	ng3¹		1		MN	184
	rs734376^1,2	A	110950281(+)	`AAGCAA/CCCCAC`	1	--	ng3¹		0	--	--	--	--
--	rs7538552^1,2	C	110951736(+)	`GCCCGA/GCTTAC`	1	--	ng3¹		0	--	--	--	--
--	rs12142824^1,2	--	110949053(+)	`GCCCCA/GAGAGC`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs3050009^1,2	--	110950301(+)	`ACACA-/GACTCCT`	1	--	ng3¹		0	--	--	--	--
--	rs11102137^1,2	--	110951669(+)	`AGCTCA/GTCACC`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KCNA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176262

4 Novoseek disease relationships for KCNA2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	32.54	9	19166925 (1), 16840785 (1), 11844797 (1), 17510053 (1) (see all 6)
necrosis	6.43	4	11741878 (2), 18562219 (1), 16774924 (1)
inflammation	4.39	3	17576778 (2), 17449059 (1)
tumors	0.00	4	11741878 (2), 12582162 (1), 16774924 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/119 PubMed articles for KCNA2 gene (see all 119 ):

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. (PubMed id 17576778)^{1, 3} Gorska M.M....Alam R. (2007)
Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A. (PubMed id 17234891)^{1, 3} Neshatian L....Diamant N.E. (2007)
Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)^{1, 3} Grissmer S....Chandy K.G. (1990)
Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)^{1, 3} Klocke R....Jockusch H. (1993)
Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins. (PubMed id 18042681)³ Pimentel C....Fajloun Z. (2008)
Clinical spectrum of voltage-gated potassium channel autoimmunity. (PubMed id 18474843)³ Tan K.M....Pittock S.J. (2008)
Expression and localization of Kv1 potassium channels in rat dorsal and ventral spinal roots. (PubMed id 18053989)³ Utsunomiya I....Taguchi K. (2008)
Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP. (PubMed id 18003609)³ Connors E.C....Morielli A.D. (2008)
An essential role for cortactin in the modulation of the potassium channel Kv1.2. (PubMed id 17959782)³ Williams M.R....Morielli A.D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3737	HGNC: 6220	AceView: KCNA2	Ensembl:ENSG00000177301	euGenes: HUgn3737
ECgene: KCNA2	H-InvDB: KCNA2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNA2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for KCNA2

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Antibodies for KCNA2

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KCNA2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for KCNA2

Summaries
for KCNA2

Genomic Location
for KCNA2

Proteins
for KCNA2

Protein Domains/
Families
for KCNA2

Gene Function
for KCNA2

Pathways & Interactions
for KCNA2

Drugs & Compounds
for KCNA2

Transcripts
for KCNA2

Expression
for KCNA2

Orthologs
for KCNA2

Paralogs
for KCNA2

SNPs/Variants
for KCNA2

Disorders & Mutations
for KCNA2

Medical News
for KCNA2

Publications
for KCNA2

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Genome Databases showing KCNA2

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Specialized Databases showing KCNA2

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNA2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor KCNA2

Summariesfor KCNA2

Genomic Locationfor KCNA2

Proteinsfor KCNA2

Protein Domains/Familiesfor KCNA2

Gene Functionfor KCNA2

Pathways & Interactionsfor KCNA2

Drugs & Compoundsfor KCNA2

Transcriptsfor KCNA2

Expression for KCNA2

Orthologsfor KCNA2

Paralogsfor KCNA2

SNPs/Variantsfor KCNA2

Disorders & Mutationsfor KCNA2

Medical Newsfor KCNA2

Publicationsfor KCNA2

Search for KCNA2

Genome Databases showing KCNA2

Other Databases showing KCNA2

Specialized Databases showing KCNA2

Licensable Technologiesfor KCNA2

Servicesfor KCNA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNA2

Summaries
for KCNA2

Genomic Location
for KCNA2

Proteins
for KCNA2

Protein Domains/
Families
for KCNA2

Gene Function
for KCNA2

Pathways & Interactions
for KCNA2

Drugs & Compounds
for KCNA2

Transcripts
for KCNA2

Expression
for KCNA2

Orthologs
for KCNA2

Paralogs
for KCNA2

SNPs/Variants
for KCNA2

Disorders & Mutations
for KCNA2

Medical News
for KCNA2

Publications
for KCNA2

Licensable Technologies
for KCNA2

Services
for KCNA2