Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA2 Gene

protein-coding   GIFtS: 61
GCID: GC01M111137

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 21 2     KV1.22
Voltage-Gated K(+) Channel HuKIV2 3     MK22
Voltage-Gated Potassium Channel HBK52 3     RBK22
Voltage-Gated Potassium Channel Subunit Kv1.22 3     Potassium Voltage-Gated Channel Subfamily A Member 22
NGK12 3     Voltage-Gated Potassium Channel Protein Kv1.22
HBK52     EC 3.6.1.278
HK42     EC 6.1.18
HUKIV2     

External Ids:    HGNC: 62201   Entrez Gene: 37372   Ensembl: ENSG000001773017   OMIM: 1762625   UniProtKB: P163893   

Export aliases for KCNA2 gene to outside databases

Previous GC identifers: GC01M111562 GC01M110012 GC01M110238 GC01M110434 GC01M110848 GC01M110947 GC01M109017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNA2 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve
cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and
the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA2 Gene: 
KCNA2 (potassium voltage-gated channel, shaker-related subfamily, member 2) is a protein-coding gene. Diseases associated with KCNA2 include episodic ataxia type 1, and benign neonatal seizures, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
closed conformations in response to the voltage difference across the membrane, the protein forms a
potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
gradient

summary for KCNA2 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA2 gene promoter:
         Nkx3-1   CREB   deltaCREB   Nkx3-1 v3   STAT3   Nkx3-1 v1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

KCNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111137:  view genomic region     (about GC identifiers)

Start:
111,136,202 bp from pter      End:
111,174,096 bp from pter
Size:
37,895 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 2  
Size: 499 amino acids; 56717 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q86XG6
Alternative splicing: 2 isoforms:  P16389-1   P16389-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNA2: NX_P16389

Explore proteomics data for KCNA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16389

  • 2 DME Specific Peptides for KCNA2 (P16389)
     PETLLGD  SRSASTI 

    KCNA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNA2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191198.1  NP_004965.1  

    ENSEMBL proteins: 
     ENSP00000358785   ENSP00000433109   ENSP00000314520   ENSP00000415257  
    Reactome Protein details: P16389
    Human Recombinant Protein Products for KCNA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KCNA2
    OriGene Protein Over-expression Lysate for KCNA2
    OriGene MassSpec for KCNA2 
    OriGene Custom Protein Services for KCNA2
    GenScript Custom Purified and Recombinant Proteins Services for KCNA2
    Novus Biologicals KCNA2 Protein
    Novus Biologicals KCNA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNA2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0044224juxtaparanode region of axon ISS--

    KCNA2 for ontologies           About GeneDecksing



    KCNA2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNA2
    OriGene Custom Antibody Services for KCNA2
    GenScript Custom Superior Antibodies Services for KCNA2
    Novus Biologicals KCNA2 Antibodies
    Abcam antibodies for KCNA2
    Cloud-Clone Corp. Antibodies for KCNA2 
    ThermoFisher Antibodies for KCNA2
    LSBio Antibodies in human, mouse, rat for KCNA2 

    Assay Products for KCNA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNA2 
    Cloud-Clone Corp. CLIAs for KCNA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.2 
    Voltage-gated potassium channels

    5/9 InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1
     IPR027359 K_channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry P16389

    ProtoNet protein and cluster: P16389

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature
    IPB004049 Kv1.2 voltage-gated K+ channel signature


    UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily


    KCNA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNA2_HUMAN, P16389
    Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or
    closed conformations in response to the voltage difference across the membrane, the protein forms a
    potassium-selective channel through which potassium ions may pass in accordance with their electrochemical
    gradient

         Genatlas biochemistry entry for KCNA2:
    potassium voltage-gated channel,Drosophila shaker-related subfamily,member 2 (mouse Kv1.2 homolog),localized in
    terminal and juxtaparanodal regions of neurons

         Enzyme Numbers (IUBMB): EC 3.6.1.272 EC 6.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS2251283
    GO:0005251delayed rectifier potassium channel activity TAS1715584
    GO:0005267potassium channel activity TAS2722779
    GO:0005515protein binding ----
         
    KCNA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNA2:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcna2):
     behavior/neurological  growth/size  mortality/aging  nervous system  respiratory system 

    KCNA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KCNA2: Kcna2tm1Tem Kcna2tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNA2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA2:
    hsa-miR-520d-5p hsa-miR-137 hsa-miR-298 hsa-miR-524-5p hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidKCNA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNA2
    Sirion Biotech Customized adenovirus for overexpression of KCNA2

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of KCNA2
    OriGene clones in human, mouse for KCNA2 (see all 7)
    OriGene ORF clones in mouse, rat for KCNA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KCNA2 (NM_004974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2
    Sirion Biotech Customized lentivirus for stable overexpression of KCNA2 
                         Customized lentivirus expression plasmids for stable overexpression of KCNA2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNA2
    Search LifeMap BioReagents cell lines for KCNA2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNA2
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA2
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNA2
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for KCNA2 (P163893 ENSP000003145204) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129593, ENSP000003457314I2D: score=4 STRING: ENSP00000345731
    KCNAB1Q147223, ENSP000004199524I2D: score=4 STRING: ENSP00000419952
    CTTNQ142473, ENSP000003018434I2D: score=2 STRING: ENSP00000301843
    KCNA3P220013, ENSP000003587844I2D: score=2 STRING: ENSP00000358784
    KCNA4P224593, ENSP000003285114I2D: score=2 STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS2251283
    GO:0007268synaptic transmission TAS--
    GO:0021633optic nerve structural organization IEA--
    GO:0051259protein oligomerization ----

    KCNA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNA2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    3 IUPHAR Ligands for KCNA2 (Kv1.2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    noxiustoxin
    InhibitorNone--
    α-dendrotoxin
    InhibitorNone--
    margatoxin
    InhibitorNone--

    10 Novoseek inferred chemical compound relationships for KCNA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 68.8 3 16424170 (1), 18398666 (1), 10391889 (1)
    benzothiophene 67.7 5 19616942 (2), 19616945 (2), 20237073 (1)
    sb 203580 66 2 17481585 (1), 14499342 (1)
    potassium 39.1 19 1436093 (2), 10617203 (1), 19093881 (1), 9875368 (1) (see all 11)
    arsenite 34.7 1 15944294 (1)
    serine 32.5 2 11551945 (1), 17481585 (1)
    adenylate 9.99 2 12565831 (2)
    lipid 0 1 1436093 (1)
    phosphatidylinositol 0 1 12832460 (1)
    h2o2 0 1 14517288 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNA2 gene (2 alternative transcripts): 
    NM_001204269.1  NM_004974.3  

    Unigene Clusters for KCNA2:

    Potassium voltage-gated channel, shaker-related subfamily, member 2
    Hs.248139  [show with all ESTs], Hs.657199  [show with all ESTs]
    Unigene Representative Sequences: NM_004974, BC043564
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369770(uc009wfv.2) ENST00000485317 ENST00000316361(uc009wfw.3)
    ENST00000525120 ENST00000440270

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNA2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNA2:
    hsa-miR-520d-5p hsa-miR-137 hsa-miR-298 hsa-miR-524-5p hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidKCNA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA2
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNA2 (see all 7)
    OriGene ORF clones in mouse, rat for KCNA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KCNA2 (NM_004974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2
    Sirion Biotech Customized lentivirus for stable overexpression of KCNA2 
                         Customized lentivirus expression plasmids for stable overexpression of KCNA2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNA2
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA2

    Additional mRNA sequence: BC043564.1 

    3 DOTS entries:

    DT.208540  DT.91750614  DT.95301346 

    7 AceView cDNA sequences:

    L02752 BC043564 BI907383 BM718279 NM_004974 BP346542 AW022870 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNA2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:        -     -                                       
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for KCNA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNA2 expression in normal human tissues (normalized intensities)      KCNA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTACATA
    KCNA2 Expression
    About this image


    KCNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Eye (Sensory Organs)

    See KCNA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNA2

    SOURCE GeneReport for Unigene clusters: Hs.248139 Hs.657199
        SABiosciences Expression via Pathway-Focused PCR Array including KCNA2: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNA2
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNA2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna21 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 93.92(n)1
    99.4(a)1
      3 (46.61 cM)5
    164901  NM_008417.51  NP_032443.31 
     1071015675 
    chicken
    (Gallus gallus)
    Aves KCNA21 potassium voltage-gated channel, shaker-related subfamily, more 83.57(n)
    97.8(a)
      395117  NM_204463.1  NP_989794.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA26
    Uncharacterized protein
    96(a)
    1 ↔ 1
    4(106835258-106836757)
    African clawed frog
    (Xenopus laevis)
    Amphibia kcna2-A-prov2 Kv1.2' potassium channel 78.07(n)    AF323749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1749071 zgc:174907 76.97(n)
    92.73(a)
      562853  NM_001111170.1  NP_001104640.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel
    72(a)     --


    ENSEMBL Gene Tree for KCNA2 (if available)
    TreeFam Gene Tree for KCNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNA2 gene
    KCNA62  KCNC22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  KCNA12  
    KCNC12  KCNA42  KCNC32  KCNA32  KCND32  KCNA102  
    18/20 SIMAP similar genes for KCNA2 using alignment to 1 protein entry:     KCNA2_HUMAN(see all similar genes):
    KCNA1    KCNA5    KCNA3    KCNA4    KCNA7    KCNA10
    KCNA6    KCNB2    KCNB1    KCND1    KCND3    KCNC2
    KCNS1    KCNS2    KCND2    KCNC4    KCNF1    KCNC1

    KCNA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/751 SNPs in KCNA2 are shown (see all 751)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665017111,2
    C--109034070(+) GAGCG-/GA    
       
    /GAGA
    AGAGA
    1 -- int11NA 2
    rs753053561,2
    C--111144860(+) GTCTA-/TTTTTT 1 -- int10--------
    rs567996551,2
    --111208983(+) GAAGAC/TACAGG 1 -- ds50010--------
    rs1508410841,2
    --111208987(+) ATACAA/GGAAGT 1 -- ds50010--------
    rs1393029981,2
    --111209001(+) GATGTA/GATTGG 1 -- ds50010--------
    rs170261661,2
    C,F--111209056(+) GCCTCG/ATCTGC 1 -- ds50013Minor allele frequency- A:0.02NA 142
    rs1167467561,2
    F--111209121(+) TCCAGG/CAGGAC 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1827908271,2
    --111209164(+) CCTCAA/TGGCCA 1 -- ds50010--------
    rs1443275261,2
    --111209437(+) CATATA/GTACAC 1 -- ut310--------
    rs1874774631,2
    C--111209657(+) CCATGA/GGTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KCNA2 (111136202 - 111174096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCNA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520458CNV Loss19592680
    nsv522839CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNA2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176262    OMIM disorders: --

    17 diseases for KCNA2:    About MalaCards
    episodic ataxia type 1    benign neonatal seizures    episodic ataxia    werner syndrome
    tuberous sclerosis    lateral sclerosis    amyotrophic lateral sclerosis    ataxia
    hypoxia    cerebritis    diabetes mellitus    alzheimer's disease
    neuronitis    endotheliitis    prostate cancer    prostatitis
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for KCNA2:
    Benign neonatal seizures     Episodic ataxia

    KCNA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for KCNA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 34.2 11 19166925 (1), 20128681 (1), 16840785 (1), 11844797 (1) (see all 8)
    inflammation 11.7 5 17576778 (2), 17449059 (1), 19850376 (1), 19691016 (1)
    necrosis 10.6 6 11741878 (2), 18562219 (1), 20237073 (1), 16774924 (1) (see all 5)
    tumors 0 6 11741878 (2), 19937655 (1), 20237073 (1), 12582162 (1) (see all 5)


    Export disorders for KCNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNA2 gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with KCNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    2. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. (PubMed id 11551945)1, 9 Janknecht R. (2001)
    3. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. (PubMed id 17576778)1, 9 Gorska M.M....Alam R. (2007)
    4. Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A. (PubMed id 17234891)1, 9 Neshatian L....Diamant N.E. (2007)
    5. Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)1, 9 Grissmer S....Chandy K.G. (1990)
    6. Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)1, 9 Klocke R....Jockusch H. (1993)
    7. Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. (PubMed id 22649228)1 Zenker J....Chrast R. (2012)
    8. Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: an immunohistochemical study. (PubMed id 21906595)1 Shibuya K....Kuwabara S. (2011)
    9. Control of ionic selectivity by a pore helix residue in the Kv1.2 channel. (PubMed id 20842544)1 Chao C.C....Leung Y.M. (2010)
    10. Effect of sensor domain mutations on the properties o f voltage-gated ion channels: molecular dynamics studies of the potassium chann el Kv1.2. (PubMed id 21044565)1 Delemotte L....Tarek M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3737 HGNC: 6220 AceView: KCNA2 Ensembl:ENSG00000177301 euGenes: HUgn3737
    ECgene: KCNA2 H-InvDB: KCNA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNA2 gene:
    Search GeneIP for patents involving KCNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Clones for the Expression of KCNA2
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNA2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNA2   OriGene RNAi products in human, mouse, rat for KCNA2  
     OriGene qPCR primer pairs and template standards for KCNA2   OriGene Protein Over-expression Lysate for KCNA2  
     OriGene MassSpec something-or-other for KCNA2   OriGene clones in human, mouse for KCNA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNA2   OriGene Purified Protein for KCNA2  
     OriGene ORF clones in mouse, rat for KCNA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNA2   OriGene Custom Protein Services for KCNA2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNA2
     QIAGEN SeqTarget long-range PCR primers for resequencing KCNA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA2
     GenScript Custom Purified and Recombinant Proteins Services for KCNA2 GenScript cDNA clones with any tag delivered in your preferred vector for KCNA2
     GenScript Custom Assay Services for KCNA2 GenScript Custom Superior Antibodies Services for KCNA2
     GenScript Custom overexpressing Cell Line Services for KCNA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNA2 promoter
     Search Chromatin IP Primers for KCNA2
     RT2 qPCR Primer Assay in human, mouse, rat KCNA2
     GNC Network for KCNA2
     SABiosciences PCR Arrays including human, mouse, rat KCNA2
     Tocris compounds for KCNA2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNA2 antibodies
     KCNA2 proteins
     KCNA2 lysates
     Antibodies for KCNA2
     See all of Abcam's Antibodies, Kits and Proteins for KCNA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KCNA2
     Antibodies for KCNA2
     ELISAs for KCNA2
     CLIAs for KCNA2
     Search LifeMap BioReagents cell lines for KCNA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2
     SwitchGear 3'UTR luciferase reporter plasmids for KCNA2
     SwitchGear Promoter luciferase reporter plasmids for KCNA2
     ThermoFisher Antibodies for KCNA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNA2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNA2
    Customized:
     lentivirus for stable overexpression of KCNA2
     lentivirus expression plasmids for stable overexpression of KCNA2
     adenovirus for overexpression of KCNA2
     LSBio Antibodies in human, mouse, rat for KCNA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNA2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4