KCNA2 Gene
protein-coding GIFtS: 59
GCID: GC01M111137
|
|
potassium voltage-gated channel, shaker-related subfamily,...
| |
Aliases
for KCNA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 21 2 | | HUKIV2 | | HK41 2 | | KV1.22 | | Voltage-Gated K(+) Channel HuKIV2 3 | | MK22 | | Voltage-Gated Potassium Channel HBK52 3 | | RBK22 | | Voltage-Gated Potassium Channel Subunit Kv1.22 3 | | Potassium Voltage-Gated Channel Subfamily A Member 22 | | NGK12 3 | | Voltage-Gated Potassium Channel Protein Kv1.22 | | Kv1.21 | | EC 3.6.1.278 | | HBK52 | | EC 6.1.18 |
Export aliases for KCNA2 gene to outside databasesPrevious GC identifers: GC01M111562 GC01M110012 GC01M110238 GC01M110434 GC01M110848 GC01M110947 GC01M109017 |
Summaries
for KCNA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNA2:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structuralstandpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Foursequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and eachhas been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated,shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourthsegment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarizefollowing an action potential. The coding region of this gene is intronless, and the gene is clustered with genesKCNA3 and KCNA10 on chromosome 1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closedconformations in response to the voltage difference across the membrane, the protein forms a potassium-selectivechannel through which potassium ions may pass in accordance with their electrochemical gradient
 summary
for KCNA2:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNA2
|
Genomic Views
for KCNA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNA2 gene promoter:
Nkx3-1 CREB deltaCREB Nkx3-1 v3 STAT3 Nkx3-1 v1 Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13KCNA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M111137: view genomic region
(about GC identifiers)
Start:
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111,136,202 bp from pter |
End:
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111,174,096 bp from pter |
Size:
|
37,895 bases |
Orientation:
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minus strand |
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Proteins
for KCNA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily A member 2 Size: 499 amino acids; 56717 Da
Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q86XG6Alternative splicing: 2 isoforms: P16389-1 P16389-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCNA2: NX_P16389
Post-translational modifications:
Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P16389
2 DME Specific Peptides for KCNA2 (P16389)
KCNA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191198.1 NP_004965.1
ENSEMBL proteins: ENSP00000358785 ENSP00000433109 ENSP00000314520 ENSP00000415257 Reactome Protein details: P16389
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0044224 | juxtaparanode region of axon |
ISS | -- |
KCNA2 for ontologies About GeneDecksing
KCNA2 Antibody Products:
Assay Products for KCNA2: |
Protein
Domains /
Families
for KCNA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNA2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P16389ProtoNet protein and cluster: P16389 4 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003972 Skaker voltage-gated K+ channel family signature IPB004049 Kv1.2 voltage-gated K+ channel signature
UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may playa role in modulation of channel activity and/or targeting of the channel to specific subcellular compartmentsDomain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third positionSimilarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily |
Function
for KCNA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCNA2_HUMAN, P16389Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closedconformations in response to the voltage difference across the membrane, the protein forms a potassium-selectivechannel through which potassium ions may pass in accordance with their electrochemical gradient Genatlas biochemistry entry for KCNA2:potassium voltage-gated channel,Drosophila shaker-related subfamily,member 2 (mouse Kv1.2 homolog),localized interminal and juxtaparanodal regions of neurons
Enzyme Numbers (IUBMB): EC 3.6.1.272 EC 6.1.12
Clone
Products: |  | EMD Millipore Clones for the Expression of KCNA2 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KCNA2 (NM_004974) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
KCNA2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KCNA2:
Animal Models:
Mouse knock-outs for KCNA2: Kcna2tm1Tem Kcna2tm1Lex
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Kcna2):
KCNA2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 3 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KCNA2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA2
3 
Reactome Pathways for KCNA2
KCNA2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for KCNA2 (P163893 ENSP000003145204) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
KCNA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNA2 for compounds About GeneDecksing
Compounds for KCNA2 available from Tocris Bioscience About this table
10 Novoseek chemical compound relationships for KCNA2 gene About this table
Search CenterWatch for drugs/clinical trials and news about KCNA2
|
Transcripts
for KCNA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNA2 gene (2 alternative transcripts): NM_001204269.1 NM_004974.3 Unigene Clusters for KCNA2: Potassium voltage-gated channel, shaker-related subfamily, member 2 Hs.248139 [show with all ESTs], Hs.657199 [show with all ESTs]Unigene Representative Sequences: NM_004974, BC0435645 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369770(uc009wfv.2) ENST00000485317 ENST00000316361(uc009wfw.3)
ENST00000525120 ENST00000440270
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KCNA2 (NM_004974) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2 |
Additional cDNA sequence: BC043564.1 3 DOTS entries: DT.208540 DT.91750614 DT.95301346 7 AceView cDNA sequences: BI907383 NM_004974 BM718279 L02752 BC043564 BP346542 AW022870
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNA2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KCNA2
|
Expression
for KCNA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGTACATA
About this image
See KCNA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNA2
SOURCE GeneReport for Unigene clusters: Hs.248139 Hs.657199
SABiosciences Expression via Pathway-Focused PCR Array including KCNA2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2 |
Orthologs
for KCNA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNA2 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNA21 |
potassium voltage-gated channel, shaker-related subfamily, more |
83.57(n)
97.8(a) |
|
395117 NM_204463.1 NP_989794.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KCNA26 |
-- |
96(a) |
1 ↔ 1 |
4(106835258-106836757) |
African clawed frog
(Xenopus laevis) |
Amphibia |
kcna2-A-prov2 |
Kv1.2' potassium channel |
78.07(n) |
|
AF323749.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1749071 |
zgc:174907 |
76.97(n)
92.73(a) |
|
562853 NM_001111170.1 NP_001104640.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sh3 |
courtship behavior voltage-gated potassium
channel |
72(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
shk-16 |
Protein SHK-1, isoform a |
36(a) |
possible ortholog |
II(9758175-9768206) |
ENSEMBL Gene Tree for KCNA2 (if available)
TreeFam Gene Tree for KCNA2 (if available) |
Paralogs
for KCNA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNA2 gene
- KCNA62 KCNC22 KCNC42 KCND22 KCND12 KCNA72 KCNA52 KCNA12
- KCNC12 KCNA42 KCNC32 KCND32 KCNA32 KCNA102
18/23 SIMAP similar genes for KCNA2 using alignment to 1 protein entry: KCNA2_HUMAN(see all similar genes):KCNA1 KCNA5 KCNA3 KCNA4 KCNA7 KCNA10
KCNA6 KCNB2 KCNB1 KCND1 KCND3 KCNC2
KCNS1 KCNS2 KCND2 KCNC4 KCNF1 KCNC1
KCNA2 for paralogs About GeneDecksing
|
Genomic Variants
for KCNA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNA2 (111136202 - 111174096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNA2 |
|
Disorders
/ Diseases
for KCNA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNA2 for disorders About GeneDecksing
OMIM gene information: 176262
OMIM disorders: --
15  diseases for KCNA2: About MalaCardsamyotrophic lateral sclerosis episodic ataxia lateral sclerosis tuberous sclerosis
werner syndrome neuronitis ataxia alzheimer's disease
prostate cancer breast cancer cerebritis hypoxia
prostatitis immunodeficiency sepsis
2 diseases from the University of Copenhagen DISEASES database for KCNA2:Benign neonatal seizures Episodic ataxia 4 Novoseek disease relationships for KCNA2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
34.2 |
11 |
19166925 (1), 20128681 (1), 16840785 (1), 11844797 (1) (see all 8) |
| inflammation |
11.7 |
5 |
17576778 (2), 17449059 (1), 19850376 (1), 19691016 (1) |
| necrosis |
10.6 |
6 |
11741878 (2), 18562219 (1), 20237073 (1), 16774924 (1) (see all 5) |
| tumors |
0 |
6 |
11741878 (2), 19937655 (1), 20237073 (1), 12582162 (1) (see all 5) |
Export disorders for KCNA2 gene to outside databases
|
Publications
for KCNA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNA2 gene, integrated from 9 sources (see all 154):
(articles sorted by number of sources associating them with KCNA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
- Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. (PubMed id 11551945)1, 9 Janknecht R. (2001)
- MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. (PubMed id 17576778)1, 9 Gorska M.M....Alam R. (2007)
- Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A. (PubMed id 17234891)1, 9 Neshatian L....Diamant N.E. (2007)
- Expression and chromosomal localization of a lymphocyte K+ channel gene. (PubMed id 2251283)1, 9 Grissmer S....Chandy K.G. (1990)
- Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. (PubMed id 7905852)1, 9 Klocke R....Jockusch H. (1993)
- Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. (PubMed id 22649228)1 Zenker J....Chrast R. (2012)
- Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: an immunohistochemical study. (PubMed id 21906595)1 Shibuya K....Kuwabara S. (2011)
- Control of ionic selectivity by a pore helix residue in the Kv1.2 channel. (PubMed id 20842544)1 Chao C.C....Leung Y.M. (2010)
- Effect of sensor domain mutations on the properties o f voltage-gated ion channels: molecular dynamics studies of the potassium chann el Kv1.2. (PubMed id 21044565)1 Delemotte L....Tarek M. (2010)
|
External Searches for KCNA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNA2 gene:
Search GeneIP for patents involving KCNA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for KCNA2 | | OriGene shRNA RFP for KCNA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNA2 | | | OriGene Protein Over-expression Lysate for KCNA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNA2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KCNA2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNA2 | | OriGene Custom Protein Services for KCNA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA2 |
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| | | | Tocris compounds for KCNA2 |
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 | | | KCNA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA2 |
|  |  |  | | | | ThermoFisher Antibodies for KCNA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA2 |
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