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Aliases for KCNA10 Gene

Aliases for KCNA10 Gene

  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 10 2 3
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.8 3 4
  • Potassium Voltage-Gated Channel Subfamily A Member 10 3
  • Cyclic GMP Gated Potassium Channel 3
  • Kv1.8 3
  • Kcn1 3

External Ids for KCNA10 Gene

Previous GeneCards Identifiers for KCNA10 Gene

  • GC01M111476
  • GC01M109926
  • GC01M110161
  • GC01M110358
  • GC01M110772
  • GC01M110861
  • GC01M111059
  • GC01M108931

Summaries for KCNA10 Gene

Entrez Gene Summary for KCNA10 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA10 Gene

KCNA10 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 10) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCND2.

UniProtKB/Swiss-Prot for KCNA10 Gene

  • Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Gene Wiki entry for KCNA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA10 Gene

Genomics for KCNA10 Gene

Regulatory Elements for KCNA10 Gene

Genomic Location for KCNA10 Gene

Start:
110,517,217 bp from pter
End:
110,519,175 bp from pter
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for KCNA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA10 Gene

Proteins for KCNA10 Gene

  • Protein details for KCNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16322-KCA10_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 10
    Protein Accession:
    Q16322
    Secondary Accessions:

    Protein attributes for KCNA10 Gene

    Size:
    511 amino acids
    Molecular mass:
    57785 Da
    Quaternary structure:
    • Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

neXtProt entry for KCNA10 Gene

Proteomics data for KCNA10 Gene at MOPED

Post-translational modifications for KCNA10 Gene

  • Glycosylation at Asn256, Asn334, and Asn498
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNA10 Gene

Domains for KCNA10 Gene

Gene Families for KCNA10 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16322

UniProtKB/Swiss-Prot:

KCA10_HUMAN :
  • Q16322
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
genes like me logo Genes that share domains with KCNA10: view

Function for KCNA10 Gene

Molecular function for KCNA10 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10
UniProtKB/Swiss-Prot Function:
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Gene Ontology (GO) - Molecular Function for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005221 intracellular cyclic nucleotide activated cation channel activity TAS 9177773
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNA10: view
genes like me logo Genes that share phenotypes with KCNA10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNA10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNA10 Gene

Localization for KCNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA10 Gene COMPARTMENTS Subcellular localization image for KCNA10 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNA10: view

Pathways for KCNA10 Gene

genes like me logo Genes that share pathways with KCNA10: view

Pathways by source for KCNA10 Gene

1 Qiagen pathway for KCNA10 Gene

Gene Ontology (GO) - Biological Process for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 9177773
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNA10: view

Compounds for KCNA10 Gene

(1) HMDB Compounds for KCNA10 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(7) IUPHAR Ligand for KCNA10 Gene

Ligand Type Action Affinity Pubmed IDs
ketoconazole Pore Blocker None 6.3
pimozide Antagonist Antagonist 6.2
charybdotoxin Inhibitor None
verapamil Inhibitor Inhibition
4-aminopyridine Inhibitor None
Ba2+ Pore Blocker Antagonist
tetraethylammonium Inhibitor None
genes like me logo Genes that share compounds with KCNA10: view

Transcripts for KCNA10 Gene

mRNA/cDNA for KCNA10 Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNA10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA10 Gene

No ASD Table

Relevant External Links for KCNA10 Gene

GeneLoc Exon Structure for
KCNA10
ECgene alternative splicing isoforms for
KCNA10

Expression for KCNA10 Gene

mRNA expression in normal human tissues for KCNA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA10 Gene

This gene is overexpressed in Testis (22.3) and Lung (6.6).

SOURCE GeneReport for Unigene cluster for KCNA10 Gene Hs.248140

mRNA Expression by UniProt/SwissProt for KCNA10 Gene

Q16322-KCA10_HUMAN
Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.
genes like me logo Genes that share expressions with KCNA10: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for KCNA10 Gene

Orthologs for KCNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNA10 35
  • 91.52 (n)
  • 94.13 (a)
KCNA10 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA10 35
  • 90.31 (n)
  • 92.34 (a)
KCNA10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna10 35
  • 88.78 (n)
  • 93.74 (a)
Kcna10 16
Kcna10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNA10 35
  • 99.22 (n)
  • 99.61 (a)
KCNA10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911265 35
  • 88.32 (n)
  • 92.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNA10 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA10 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA10 35
  • 76.84 (n)
  • 77.89 (a)
KCNA10 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA10 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna10 35
  • 68.55 (n)
  • 74.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329515 35
  • 67.79 (n)
  • 72.3 (a)
KCNA10 (1 of 2) 36
  • 63 (a)
OneToMany
KCNA10 (2 of 2) 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 66 (a)
Sh 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48A6B.6 37
  • 35 (a)
Y55F3C.3 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for KCNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA10 Gene

ENSEMBL:
Gene Tree for KCNA10 (if available)
TreeFam:
Gene Tree for KCNA10 (if available)

Paralogs for KCNA10 Gene

Selected SIMAP similar genes for KCNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA10: view

Variants for KCNA10 Gene

Sequence variations from dbSNP and Humsavar for KCNA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1281174 -- 110,518,440(-) CGGGA(A/G)AAAAG reference, synonymous-codon
rs1281175 -- 110,518,047(-) GAGCT(A/G)AAGGT reference, synonymous-codon
rs1281176 -- 110,516,802(-) GTTTT(G/T)GTCTT downstream-variant-500B
rs1339702 -- 110,517,681(-) CTGAA(A/G)GCGTC synonymous-codon, reference
rs1779457 -- 110,519,150(-) CTTAA(A/G)GAATG utr-variant-5-prime

Relevant External Links for KCNA10 Gene

HapMap Linkage Disequilibrium report
KCNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNA10 Gene

Disorders for KCNA10 Gene

(1) University of Copenhagen DISEASES for KCNA10 Gene

Relevant External Links for KCNA10

Genetic Association Database (GAD)
KCNA10
Human Genome Epidemiology (HuGE) Navigator
KCNA10
genes like me logo Genes that share disorders with KCNA10: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for KCNA10 Gene

Publications for KCNA10 Gene

  1. KCNA10: a novel ion channel functionally related to both voltage- gated potassium and CNG cation channels. (PMID: 10836990) Lang R. … Desir G.V. (Am. J. Physiol. 2000) 3 4 23
  2. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PMID: 12444201) Yao X. … Desir G.V. (J. Am. Soc. Nephrol. 2002) 3 4 23
  3. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. (PMID: 9177773) Orias M. … Desir G.V. (Genomics 1997) 3 4
  4. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PMID: 12060596) Tian S. … Desir G.V. (Am. J. Physiol. 2002) 3 4
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3

Products for KCNA10 Gene

Sources for KCNA10 Gene

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