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Aliases for KCNA10 Gene

Aliases for KCNA10 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 10 2 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.8 3 4
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 10 3
  • Cyclic GMP Gated Potassium Channel 3
  • Kv1.8 3
  • Kcn1 3

External Ids for KCNA10 Gene

Previous GeneCards Identifiers for KCNA10 Gene

  • GC01M111476
  • GC01M109926
  • GC01M110161
  • GC01M110358
  • GC01M110772
  • GC01M110861
  • GC01M111059
  • GC01M108931

Summaries for KCNA10 Gene

Entrez Gene Summary for KCNA10 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA10 Gene

KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Potassium Channels and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include ion channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA4.

UniProtKB/Swiss-Prot for KCNA10 Gene

  • Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Gene Wiki entry for KCNA10 Gene

Additional gene information for KCNA10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA10 Gene

Genomics for KCNA10 Gene

Regulatory Elements for KCNA10 Gene

Enhancers for KCNA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H110618 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -100.5 -100499 1 ATF1 SIN3A ZNF2 GLIS2 ZNF143 KLF7 ATF7 RUNX3 REST MEF2D KCNA3 GSTM2 KCNA10 CD53 KCNA2 RBM15 GC01M110604
GH01H110630 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -116.6 -116610 10 HDGF TBL1XR1 BATF RAD21 SCRT2 ZNF143 FOS ATF7 KLF7 ETV6 CD53 KCNA3 KCNA2 KCNA10 KCNC4-AS1 LRIF1 RBM15 ENSG00000259834
GH01H110421 1.5 FANTOM5 Ensembl ENCODE 9.2 +97.8 97752 0 HDAC1 ATF1 ZNF766 GATA2 FOS ATF7 HDAC8 MEF2D SMARCA4 KDM1A PROK1 CD53 RBM15 RBM15-AS1 KCNC4 KCNC4-AS1 KCNA10 GC01M110420
GH01H110784 1.3 FANTOM5 Ensembl ENCODE 10.6 -267.5 -267494 4 BCOR ZBTB21 RBBP5 FEZF1 EBF1 ZEB1 RELA ZNF664 POLR2A EED KCNA2 STRIP1 CD53 KCNA10 DENND2D DRAM2 ENSG00000199710 GC01M110765 GC01P110827
GH01H110476 1.2 Ensembl ENCODE 11.1 +41.5 41470 1 TCF12 GATA2 ATF7 FOS NCOA1 SMARCA4 STAT3 NR2C1 KDM1A WT1 PROK1 KCNA10 KCNC4 KCNC4-AS1 CYMP ENSG00000283999
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNA10 Gene

Chromosome:
1
Start:
110,517,217 bp from pter
End:
110,519,175 bp from pter
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for KCNA10 Gene

Genes around KCNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA10 Gene

Proteins for KCNA10 Gene

  • Protein details for KCNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16322-KCA10_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 10
    Protein Accession:
    Q16322

    Protein attributes for KCNA10 Gene

    Size:
    511 amino acids
    Molecular mass:
    57785 Da
    Quaternary structure:
    • Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

neXtProt entry for KCNA10 Gene

Post-translational modifications for KCNA10 Gene

  • Glycosylation at isoforms=256, isoforms=334, and isoforms=498
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA10 Gene

Domains & Families for KCNA10 Gene

Gene Families for KCNA10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16322

UniProtKB/Swiss-Prot:

KCA10_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
genes like me logo Genes that share domains with KCNA10: view

Function for KCNA10 Gene

Molecular function for KCNA10 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10
UniProtKB/Swiss-Prot Function:
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Phenotypes From GWAS Catalog for KCNA10 Gene

Gene Ontology (GO) - Molecular Function for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005221 intracellular cyclic nucleotide activated cation channel activity TAS 9177773
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005267 potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNA10: view
genes like me logo Genes that share phenotypes with KCNA10: view

Animal Models for KCNA10 Gene

MGI Knock Outs for KCNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA10

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCNA10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA10 Gene

Localization for KCNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNA10 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNA10: view

Pathways & Interactions for KCNA10 Gene

genes like me logo Genes that share pathways with KCNA10: view

Pathways by source for KCNA10 Gene

1 Qiagen pathway for KCNA10 Gene

Gene Ontology (GO) - Biological Process for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 9177773
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNA10: view

No data available for SIGNOR curated interactions for KCNA10 Gene

Drugs & Compounds for KCNA10 Gene

(9) Drugs for KCNA10 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Aminopyridine Approved Pharma Pore Blocker, Target, antagonist potassium channel-blocking agent, Non-selective KV channel blocker 71
Ketoconazole Approved, Investigational Pharma Pore Blocker, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 178
Pimozide Approved Pharma Antagonist, Pore Blocker, antagonist 12
Verapamil Approved Pharma Channel blocker, blocker 130
tetraethylammonium Experimental Pharma Inhibitor 1
genes like me logo Genes that share compounds with KCNA10: view

Transcripts for KCNA10 Gene

mRNA/cDNA for KCNA10 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCNA10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA10 Gene

No ASD Table

Relevant External Links for KCNA10 Gene

GeneLoc Exon Structure for
KCNA10
ECgene alternative splicing isoforms for
KCNA10

Expression for KCNA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA10 Gene

This gene is overexpressed in Testis (x22.3) and Lung (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of KCNA10 Gene:

KCNA10

SOURCE GeneReport for Unigene cluster for KCNA10 Gene:

Hs.248140

mRNA Expression by UniProt/SwissProt for KCNA10 Gene:

Q16322-KCA10_HUMAN
Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.

Evidence on tissue expression from TISSUES for KCNA10 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with KCNA10: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNA10 Gene

Orthologs for KCNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA10 33 34
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia KCNA10 33 34
  • 91.52 (n)
dog
(Canis familiaris)
Mammalia KCNA10 33 34
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNA10 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna10 33 16 34
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia Kcna10 33
  • 88.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA10 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA10 33 34
  • 76.84 (n)
lizard
(Anolis carolinensis)
Reptilia KCNA10 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna10 33
  • 68.55 (n)
zebrafish
(Danio rerio)
Actinopterygii KCNA10 (2 of 2) 34
  • 71 (a)
OneToMany
LOC100329515 33
  • 67.79 (n)
KCNA10 (1 of 2) 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sh 35 34
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48A6B.6 35
  • 35 (a)
Y55F3C.3 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
Species where no ortholog for KCNA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA10 Gene

ENSEMBL:
Gene Tree for KCNA10 (if available)
TreeFam:
Gene Tree for KCNA10 (if available)

Paralogs for KCNA10 Gene

(22) SIMAP similar genes for KCNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA10: view

Variants for KCNA10 Gene

Sequence variations from dbSNP and Humsavar for KCNA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs755748044 A colorectal cancer sample 110,518,189(+) ACTGA(C/G/T)GGTGG reference, missense
rs1001793431 -- 110,520,962(+) TTTTT(G/T)GGGAG upstream-variant-2KB
rs1002396549 -- 110,519,465(+) AATAA(C/G)TCCTA upstream-variant-2KB
rs1002743758 -- 110,518,494(+) TGGGT(C/G)TCAAA reference, missense
rs1002774806 -- 110,518,670(+) AGGCC(A/G)GCCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KCNA10 Gene

Variant ID Type Subtype PubMed ID
nsv1006346 CNV gain 25217958
nsv547498 CNV loss 21841781

Variation tolerance for KCNA10 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA10 Gene

Disorders for KCNA10 Gene

Relevant External Links for KCNA10

Genetic Association Database (GAD)
KCNA10
Human Genome Epidemiology (HuGE) Navigator
KCNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA10

No disorders were found for KCNA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNA10 Gene

Publications for KCNA10 Gene

  1. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PMID: 12444201) Yao X … Desir GV (Journal of the American Society of Nephrology : JASN 2002) 3 4 22 60
  2. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. (PMID: 10836990) Lang R … Desir GV (American journal of physiology. Renal physiology 2000) 3 4 22 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3 60
  5. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PMID: 12060596) Tian S … Desir GV (American journal of physiology. Renal physiology 2002) 3 4 60

Products for KCNA10 Gene

Sources for KCNA10 Gene

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