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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNA10 Gene

protein-coding   GIFtS: 58
GCID: GC01M111059

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member
101 2
Voltage-Gated Potassium Channel Subunit Kv1.82 3
Kcn12
Kv1.82
Cyclic GMP Gated Potassium Channel2
Potassium Voltage-Gated Channel Subfamily A Member 102

External Ids:    HGNC: 62191   Entrez Gene: 37442   Ensembl: ENSG000001431057   OMIM: 6024205   UniProtKB: Q163223   

Export aliases for KCNA10 gene to outside databases

Previous GC identifers: GC01M111476 GC01M109926 GC01M110161 GC01M110358 GC01M110772 GC01M110861 GC01M108931


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNA10 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the
effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with
genes KCNA2 and KCNA3 on chromosome 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA10 Gene: 
KCNA10 (potassium voltage-gated channel, shaker-related subfamily, member 10) is a protein-coding gene. Diseases associated with KCNA10 include long qt syndrome, and neuronitis, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel
activity is up-regulated by cAMP

Gene Wiki entry for KCNA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNA10 gene promoter:
         ER-alpha   p300   PPAR-alpha   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   ZID   Zic3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.1

KCNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111059:  view genomic region     (about GC identifiers)

Start:
111,059,839 bp from pter      End:
111,061,797 bp from pter
Size:
1,959 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 10  
Size: 511 amino acids; 57785 Da
Subunit: Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of
channel activity by cAMP
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNA10: NX_Q16322

Explore proteomics data for KCNA10 at MOPED 

KCNA10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KCNA10 Protein Expression

REFSEQ proteins: NP_005540.1  
ENSEMBL proteins: 
 ENSP00000358786  
Reactome Protein details: Q16322
Human Recombinant Protein Products for KCNA10: 
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Cloud-Clone Corp. Proteins for KCNA10 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0008076voltage-gated potassium channel complex IEA--
GO:0016020membrane ----

KCNA10 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for KCNA10


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KCN: Potassium channels
Kv: Voltage-gated ion channels / Potassium channels

IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.8 
Voltage-gated potassium channels

5/8 InterPro protein domains (see all 8):
 IPR005821 Ion_trans_dom
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003972 K_chnl_volt-dep_Kv1
 IPR027359 K_channel_four-helix_dom

Graphical View of Domain Structure for InterPro Entry Q16322

ProtoNet protein and cluster: Q16322

3 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003972 Skaker voltage-gated K+ channel family signature


UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
compartments
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
acids at every third position
Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily


KCNA10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCA10_HUMAN, Q16322
Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel
activity is up-regulated by cAMP

     Genatlas biochemistry entry for KCNA10:
potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005221intracellular cyclic nucleotide activated cation channel activity TAS9177773
GO:0005251delayed rectifier potassium channel activity IBA--
GO:0005515protein binding ----
     
KCNA10 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for KCNA10:
 Increased cell death in HCC-19  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

Animal Models:
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miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA10
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KCNA10 About                                                                                                See pathways by source

SuperPathContained pathways About
1Potassium Channels
Potassium Channels0.43
Potassium transporters: outward current0.42
Voltage gated Potassium channels0.43
2Transmission across Chemical Synapses
Neuronal System0.67
3Dopamine-DARPP32 Feedback onto cAMP Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for KCNA10
    Potassium transporters- outward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNA10
    Dopamine-DARPP32 Feedback onto cAMP Pathway

3        Reactome Pathways for KCNA10
    Potassium Channels
Neuronal System
Voltage gated Potassium channels



KCNA10 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNA10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for KCNA10 (Q163223 ENSP000003587864) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
POMPQ9Y2443, ENSP000003702224I2D: score=1 STRING: ENSP00000370222
KCNA2ENSP000003145204STRING: ENSP00000314520
KCNA3ENSP000003587844STRING: ENSP00000358784
KCNA4ENSP000003285114STRING: ENSP00000328511
KCNA5ENSP000002523214STRING: ENSP00000252321
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----
GO:0006813potassium ion transport TAS9177773
GO:0007268synaptic transmission TAS--
GO:0051260protein homooligomerization IEA--
GO:0055085transmembrane transport ----

KCNA10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KCNA10 (KCA10)

1 HMDB Compound for KCNA10    About this table
CompoundSynonyms CAS #PubMed Ids
Cyclic AMPCyclic AMP (see all 19)60-92-4--

7 IUPHAR Ligands for KCNA10 (Kv1.8)    About this table 
LigandTypeActionAffinityPubmed IDs
charybdotoxin
Pore BlockerNone710836990
pimozide
Pore BlockerNone6.510836990
ketoconazole
Pore BlockerNone6.310836990
verapamil
Pore BlockerNone4.310836990
4-aminopyridine
Pore BlockerNone2.810836990
Ba2+
Pore BlockerNone2.310836990
tetraethylammonium
Pore BlockerNone1.310836990

Search CenterWatch for drugs/clinical trials and news about KCNA10 / KCA10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNA10 gene: 
NM_005549.2  

Unigene Cluster for KCNA10:

Potassium voltage-gated channel, shaker-related subfamily, member 10
Hs.248140
Unigene Representative Sequence: NM_005549
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000369771(uc001dzt.1)
miRNA
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Inhib. RNA
Products:
     
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNA10
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                     Customized lentivirus expression plasmids for stable overexpression of KCNA10 
Primer
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OriGene qPCR primer pairs and template standards for KCNA10
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNA10
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNA10

Additional mRNA sequence: BC074990.2 

1 DOTS entry:

DT.91678539 

2 AceView cDNA sequences:

BC069165 CA309199 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNA10 expression in normal human tissues (normalized intensities)      KCNA10 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCCGACCA
KCNA10 Expression
About this image


KCNA10 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/27 selected tissues (see all 27) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
         colon ; peripheral nerve/ganglion   
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Lung (Respiratory System)    fully expand to see all 3 entries
         lung ; pneumocytes   
 
 Breast
         breast ; myoepithelial cells   

See KCNA10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNA10

SOURCE GeneReport for Unigene cluster: Hs.248140

UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and
in smooth muscle cells

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNA10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNA10 gene from 5/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcna101 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 88.78(n)1
93.74(a)1
  3 (46.64 cM)5
2421511  NM_001081140.11  NP_001074609.11 
 1071830565 
chicken
(Gallus gallus)
Aves KCNA101 potassium voltage-gated channel, shaker-related subfamily, more 76.84(n)
77.89(a)
  395116  NM_204462.1  NP_989793.1 
lizard
(Anolis carolinensis)
Reptilia KCNA106
Uncharacterized protein
72(a)
1 ↔ 1
4(106714598-106716169)
zebrafish
(Danio rerio)
Actinopterygii KCNA10 (1 of 2)6
KCNA10 (2 of 2)6
potassium voltage-gated channel, shaker-related su...
potassium voltage-gated channel, shaker-related su...
71(a)
62(a)
1 ↔ many
1 ↔ many
23(5188668-5190107)
6(49408463-49410169)
fruit fly
(Drosophila melanogaster)
Insecta Sh3 courtship behavior voltage-gated
potassium channel
66(a)     --


ENSEMBL Gene Tree for KCNA10 (if available)
TreeFam Gene Tree for KCNA10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KCNA10 gene
KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
KCNA12  KCNC12  KCNA42  KCNC32  KCNA32  KCND32  
18/22 SIMAP similar genes for KCNA10 using alignment to 1 protein entry:     KCA10_HUMAN(see all similar genes):
KCNA1    KCNA3    KCNA4    KCNA7    KCNA5    KCNA2
KCNA6    KCNB1    KCNB2    KCND1    KCND3    KCNC2
KCNS2    KCNC1    KCND2    KCNS1    KCNC4    KCNF1

KCNA10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/189 SNPs in KCNA10 are shown (see all 189)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0367784
A colorectal cancer sample4--see VAR_0367782 R H mis40--------
rs1397208771,2
--111059380(+) TTGCTC/GACAGC 1 -- ds50010--------
rs12811761,2
C,F--111059424(-) GTTTTG/TGTCTT 1 -- ds50016Minor allele frequency- T:0.20NA WA EA 364
rs1921523711,2
--111059712(+) ACATTC/TTGATC 1 -- ds50010--------
rs1497925481,2
C--111059715(+) TTTTGA/GTCTTT 1 -- ds50010--------
rs1822118341,2
C--111059717(+) TTGATC/TTTTGG 1 -- ds50010--------
rs1860018291,2
--111059723(+) TTTGGA/GAAGAT 1 -- ds50010--------
rs2021678501,2
--111059737(+) ATGAG-/AGAAGGGA 1 -- ds50010--------
rs2020290111,2
--111059738(+) TGAGA-/GAAG  
        
GGAGA
1 -- ds50010--------
rs38418461,2
C--111059812(-) TCTCT-/TCTCTCT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for KCNA10 (111059839 - 111061797 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KCNA10: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KCNA10
DNA2.0 Custom Variant and Variant Library Synthesis for KCNA10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 602420    OMIM disorders: --

2 diseases for KCNA10:    About MalaCards
long qt syndrome    neuronitis

1 disease from the University of Copenhagen DISEASES database for KCNA10:
Long QT syndrome

KCNA10 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNA10
Human Genome Epidemiology (HuGE) Navigator: KCNA10 (3 documents)

Export disorders for KCNA10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCNA10 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with KCNA10)
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  1. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PubMed id 12444201)1, 2, 9 Yao X.... Desir G.V. (2002)
  2. KCNA10: a novel ion channel functionally related to both voltage- gated potassium and CNG cation channels. (PubMed id 10836990)1, 2, 9 Lang R....Desir G.V. (2000)
  3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  4. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
  5. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PubMed id 12060596)1, 2 Tian S.... Desir G.V. (2002)
  6. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. (PubMed id 9177773)1, 2 Orias M.... Desir G.V. (1997)
  7. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
  8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  9. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)4 Scott L.J....Boehnke M. (2007)
  10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3744 HGNC: 6219 AceView: KCNA10.1 Ensembl:ENSG00000143105 euGenes: HUgn3744
ECgene: KCNA10 H-InvDB: KCNA10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNA10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNA10 gene:
Search GeneIP for patents involving KCNA10

GeneCards and IP:
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