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Aliases for KCNA10 Gene

Aliases for KCNA10 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 10 2 3
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 10 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.8 3 4
  • Cyclic GMP Gated Potassium Channel 3
  • Kv1.8 3
  • Kcn1 3

External Ids for KCNA10 Gene

Previous GeneCards Identifiers for KCNA10 Gene

  • GC01M111476
  • GC01M109926
  • GC01M110161
  • GC01M110358
  • GC01M110772
  • GC01M110861
  • GC01M111059
  • GC01M108931

Summaries for KCNA10 Gene

Entrez Gene Summary for KCNA10 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA10 Gene

KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCND2.

UniProtKB/Swiss-Prot for KCNA10 Gene

  • Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Gene Wiki entry for KCNA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA10 Gene

Genomics for KCNA10 Gene

Regulatory Elements for KCNA10 Gene


Promoters for KCNA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNA10 Gene

Chromosome:
1
Start:
110,517,217 bp from pter
End:
110,519,175 bp from pter
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for KCNA10 Gene

Genes around KCNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA10 Gene

Proteins for KCNA10 Gene

  • Protein details for KCNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16322-KCA10_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 10
    Protein Accession:
    Q16322

    Protein attributes for KCNA10 Gene

    Size:
    511 amino acids
    Molecular mass:
    57785 Da
    Quaternary structure:
    • Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

neXtProt entry for KCNA10 Gene

Proteomics data for KCNA10 Gene at MOPED

Post-translational modifications for KCNA10 Gene

  • Glycosylation at Asn 256, Asn 334, and Asn 498
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA10 Gene

Domains & Families for KCNA10 Gene

Gene Families for KCNA10 Gene

Suggested Antigen Peptide Sequences for KCNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16322

UniProtKB/Swiss-Prot:

KCA10_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
genes like me logo Genes that share domains with KCNA10: view

Function for KCNA10 Gene

Molecular function for KCNA10 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10
UniProtKB/Swiss-Prot Function:
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
genes like me logo Genes that share phenotypes with KCNA10: view

Animal Models for KCNA10 Gene

MGI Knock Outs for KCNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA10 Gene

Localization for KCNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA10 Gene COMPARTMENTS Subcellular localization image for KCNA10 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNA10: view

Pathways & Interactions for KCNA10 Gene

genes like me logo Genes that share pathways with KCNA10: view

Pathways by source for KCNA10 Gene

1 Qiagen pathway for KCNA10 Gene

Gene Ontology (GO) - Biological Process for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNA10: view

No data available for SIGNOR curated interactions for KCNA10 Gene

Drugs & Compounds for KCNA10 Gene

(9) Drugs for KCNA10 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dalfampridine Approved Pharma Pore Blocker, Target, antagonist 65
Ketoconazole Approved, Investigational Pharma Pore Blocker, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 174
Pimozide Approved Pharma Antagonist, Pore Blocker, antagonist 11
Verapamil Approved Pharma Channel blocker, blocker 122
tetraethylammonium Experimental Pharma Inhibitor 1
genes like me logo Genes that share compounds with KCNA10: view

Transcripts for KCNA10 Gene

mRNA/cDNA for KCNA10 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA10 Gene

No ASD Table

Relevant External Links for KCNA10 Gene

GeneLoc Exon Structure for
KCNA10
ECgene alternative splicing isoforms for
KCNA10

Expression for KCNA10 Gene

mRNA expression in normal human tissues for KCNA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA10 Gene

This gene is overexpressed in Testis (x22.3) and Lung (x6.6).

SOURCE GeneReport for Unigene cluster for KCNA10 Gene Hs.248140

mRNA Expression by UniProt/SwissProt for KCNA10 Gene

Q16322-KCA10_HUMAN
Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.
genes like me logo Genes that share expression patterns with KCNA10: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNA10 Gene

Orthologs for KCNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNA10 35
  • 91.52 (n)
  • 94.13 (a)
KCNA10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna10 35
  • 88.78 (n)
  • 93.74 (a)
Kcna10 16
Kcna10 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911265 35
  • 88.32 (n)
  • 92.37 (a)
dog
(Canis familiaris)
Mammalia KCNA10 36
  • 92 (a)
OneToOne
KCNA10 35
  • 90.31 (n)
  • 92.34 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNA10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNA10 36
  • 100 (a)
OneToOne
KCNA10 35
  • 99.22 (n)
  • 99.61 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA10 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA10 35
  • 76.84 (n)
  • 77.89 (a)
KCNA10 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA10 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna10 35
  • 68.55 (n)
  • 74.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329515 35
  • 67.79 (n)
  • 72.3 (a)
KCNA10 (2 of 2) 36
  • 71 (a)
OneToMany
KCNA10 (1 of 2) 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 66 (a)
Sh 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48A6B.6 37
  • 35 (a)
Y55F3C.3 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for KCNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA10 Gene

ENSEMBL:
Gene Tree for KCNA10 (if available)
TreeFam:
Gene Tree for KCNA10 (if available)

Paralogs for KCNA10 Gene

(22) SIMAP similar genes for KCNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA10: view

Variants for KCNA10 Gene

Sequence variations from dbSNP and Humsavar for KCNA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_036778 A colorectal cancer sample
rs34970857 - 110,518,130(+) GACCA(A/C/T)GGCCA reference, missense
rs3748729 - 110,518,015(+) TCTTG(C/T)TCATG reference, missense
rs1281174 -- 110,518,440(-) CGGGA(A/G)AAAAG reference, synonymous-codon
rs1281175 -- 110,518,047(-) GAGCT(A/G)AAGGT reference, synonymous-codon

Variation tolerance for KCNA10 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA10 Gene

HapMap Linkage Disequilibrium report
KCNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNA10 Gene

Disorders for KCNA10 Gene

Relevant External Links for KCNA10

Genetic Association Database (GAD)
KCNA10
Human Genome Epidemiology (HuGE) Navigator
KCNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA10

No disorders were found for KCNA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNA10 Gene

Publications for KCNA10 Gene

  1. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PMID: 12444201) Yao X. … Desir G.V. (J. Am. Soc. Nephrol. 2002) 3 4 23 67
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. KCNA10: a novel ion channel functionally related to both voltage- gated potassium and CNG cation channels. (PMID: 10836990) Lang R. … Desir G.V. (Am. J. Physiol. 2000) 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for KCNA10 Gene

Sources for KCNA10 Gene

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