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Aliases & Descriptions for KCNA10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Kcn1 2 | | Kv1.8 1, 2 | | OTTHUMP00000024387 2 |
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv1.8 3 | | cyclic GMP gated potassium channel 2 | potassium voltage-gated channel, shaker-related subfamily, member 10 2 |
|
| | Search outside databases for aliases for KCNA10 genePrevious GC identifers: GC01M111476 GC01M109926 GC01M110161 GC01M110358 |
Summaries for KCNA10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNA10: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq] UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP |
Genomic Location for KCNA10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNA10 gene 
Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.1KCNA10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M110772:
(about GC identifiers)
Start:
|
110,861,362 bp from pter |
End:
|
110,863,320 bp from pter |
Size:
|
1,959 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_019273.18
| Proteins for KCNA10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily A member 10 Size: 511 amino acids; 57785 Da
Subunit: Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP
Subcellular location: Membrane; Multi-pass membrane proteinREFSEQ proteins: NP_005540.1
ENSEMBL proteins: ENSP00000358786
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for KCNA10: Assays for KCNA10: | Protein
Domains/ Families for KCNA10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q16322
ProtoNet protein and cluster: Q16322 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003972 Skaker voltage-gated K+ channel family signature
UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartmentsDomain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. A (Shaker) subfamily | Gene Function for KCNA10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005549
Applied Biosystems Silencer® siRNAs for KCNA10
Sigma-Aldrich siRNA and siRNA Panels for KCNA10  Sigma-Aldrich shRNA Panels and shRNA for KCNA10  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005549                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005549                                  untagged cDNA clone in CMV expression vector: NM_005549 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005549
UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMPGenatlas biochemistry entry for KCNA10:potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 105 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005221 | intracellular cyclic nucleotide activated cation channel activity |
TAS | 9177773 | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNA10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for KCNA10 (ENSP000003587863) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNA10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for KCNA10
|
Transcripts for KCNA10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005549
Sigma-Aldrich siRNA and siRNA Panels for KCNA10  Sigma-Aldrich shRNA Panels and shRNA for KCNA10  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005549 REFSEQ mRNAs for KCNA10 gene: NM_005549.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005549               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005549                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005549                                  untagged cDNA clone in CMV expression vector: NM_005549  Additional cDNA sequence: BC069165.1 BC074990.2 1 DOTS entry: DT.91678539 2 AceView cDNA sequences:BC069165 CA309199
highest scoring ESTs for KCNA10:CA309199 BC069165 BC074990 NM_005549 Unigene Cluster for KCNA10: Potassium voltage-gated channel, shaker-related subfamily, member 10 Hs.248140 Unigene Representative Sequence: NM_005549
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000369771
|
Expression for KCNA10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNA10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNA10
1 / 2 / 3 2 probe-sets matching KCNA10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGACGGCCTT
SOURCE GeneReport for Unigene cluster: Hs.248140 UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells |
Orthologs for KCNA10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNA10 gene from 5/9 species (see all 9
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNA101 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
90.31(n) 92.34(a) |
490111 XM_547232.2 XP_547232.2 |
chimpanzee (Pan troglodytes) |
KCNA101 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
99.22(n) 99.61(a) |
469414 XM_524799.2 XP_524799.2 |
cow (Bos taurus) |
KCNA101 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
91.52(n) 94.13(a) |
538721 XM_582224.3 XP_582224.2 |
rat (Rattus norvegicus) |
Kcna101 |
-- |
potassium voltage-gated channel, shaker-related subfamily, more |
88.32(n) 92.37(a) |
295360 XM_227577.4 XP_227577.2 |
mouse (Mus musculus) |
Kcna101, 5 |
3 (53.00 cM)5
|
potassium voltage-gated channel, shaker-related subfamily, more1, 5 |
88.78(n)1 93.74(a)1 |
2421511 NM_001081140.11 NP_001074609.11 AK1579655 BC1378285 (see all 8) |
About this table Species with no ortholog for KCNA10
ENSEMBL Gene Tree for KCNA10 | Paralogs for KCNA10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNA10 gene
- KCNA52 KCNA42
|
SNPs/Variants for KCNA10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNA10 (up to first 250kb)
|
Disorders & Mutations for KCNA10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602420
|
Medical News for KCNA10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNA10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for KCNA10 gene (see all 11
):- Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PubMed id 12444201)1, 3, 4 Yao X.... Desir G.V. (2002)
- KCNA10: a novel ion channel functionally related to both voltage- gated potassium and CNG cation channels. (PubMed id 10836990)1, 3, 4 Lang R....Desir G.V. (2000)
- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)2, 3 Gutman G.A....Wang X. (2005)
- Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PubMed id 12060596)3, 4 Tian S.... Desir G.V. (2002)
- Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. (PubMed id 9177773)3, 4 Orias M.... Desir G.V. (1997)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Molecular characterization and refined genomic localization of three human potassium ion channel genes. (PubMed id 7789190)3 Landes G.M.... Keating M.T. (1995)
|
Search for KCNA10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNA10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNA10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNA10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNA10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNA10:

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Incremental update: 13 Oct 2009
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