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KCNA10 Gene

protein-coding   GIFtS: 57
GCID: GC01M111059

Potassium Voltage-Gated Channel, Shaker-Related Subfamily,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member
101 2
Voltage-Gated Potassium Channel Subunit Kv1.82 3
Kcn12
Kv1.82
Cyclic GMP Gated Potassium Channel2
Potassium Voltage-Gated Channel Subfamily A Member 102

External Ids:    HGNC: 62191   Entrez Gene: 37442   Ensembl: ENSG000001431057   OMIM: 6024205   UniProtKB: Q163223   

Export aliases for KCNA10 gene to outside databases

Previous GC identifers: GC01M111476 GC01M109926 GC01M110161 GC01M110358 GC01M110772 GC01M110861 GC01M108931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNA10 Gene:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and
structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin
secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium
channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a
shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the
effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with
genes KCNA2 and KCNA3 on chromosome 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNA10 Gene:
KCNA10 (potassium voltage-gated channel, shaker-related subfamily, member 10) is a protein-coding gene. Diseases associated with KCNA10 include long qt syndrome, and breast and colorectal cancer. GO annotations related to this gene include delayed rectifier potassium channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA6.

UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel
activity is up-regulated by cAMP

Gene Wiki entry for KCNA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNA10 gene promoter:
         ER-alpha   p300   PPAR-alpha   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   ZID   Zic3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNA10 promoter sequence
   Search Chromatin IP Primers for KCNA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.1

KCNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNA10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111059:  view genomic region     (about GC identifiers)

Start:
111,059,839 bp from pter      End:
111,061,797 bp from pter
Size:
1,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily A member 10  
Size: 511 amino acids; 57785 Da
Subunit: Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of
channel activity by cAMP

Explore the universe of human proteins at neXtProt for KCNA10: NX_Q16322

Explore proteomics data for KCNA10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn256, Asn334, Asn498

  • See KCNA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005540.1  
    ENSEMBL proteins: 
     ENSP00000358786  
    Reactome Protein details: Q16322

    KCNA10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv1.8
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003972 K_chnl_volt-dep_Kv1
     IPR027359 Channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q16322

    ProtoNet protein and cluster: Q16322

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003972 Skaker voltage-gated K+ channel family signature


    UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
    Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may
    play a role in modulation of channel activity and/or targeting of the channel to specific subcellular
    compartments
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily


    KCNA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCA10_HUMAN, Q16322
    Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed
    conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective
    channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel
    activity is up-regulated by cAMP

         Genatlas biochemistry entry for KCNA10:
    potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005221intracellular cyclic nucleotide activated cation channel activity TAS9177773
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
         
    KCNA10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KCNA10:
     Increased cell death in HCC-19  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNA10
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCA10_HUMAN, Q16322: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----

    KCNA10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNA10 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNA10
        Dopamine-DARPP32 Feedback onto cAMP Pathway


    1 Reactome Pathway for KCNA10
        Voltage gated Potassium channels



    KCNA10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNA10
    Interactions:

        Search GeneGlobe Interaction Network for KCNA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNA10 (Q163223 ENSP000003587864) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POMPQ9Y2443, ENSP000003702224I2D: score=1 STRING: ENSP00000370222
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    KCNA5ENSP000002523214STRING: ENSP00000252321
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS9177773
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNA10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCNA10 (KCA10)

    1 HMDB Compound for KCNA10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    7 IUPHAR Ligands for KCNA10 (Kv1.8)    About this table
    LigandTypeActionAffinityPubmed IDs
    charybdotoxin
    Pore BlockerNone710836990
    pimozide
    Pore BlockerNone6.510836990
    ketoconazole
    Pore BlockerNone6.310836990
    verapamil
    Pore BlockerNone4.310836990
    4-aminopyridine
    Pore BlockerNone2.810836990
    Ba2+
    Pore BlockerNone2.310836990
    tetraethylammonium
    Pore BlockerNone1.310836990



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNA10 gene: 
    NM_005549.2  

    Unigene Cluster for KCNA10:

    Potassium voltage-gated channel, shaker-related subfamily, member 10
    Hs.248140
    Unigene Representative Sequence: NM_005549
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369771(uc001dzt.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KCNA10

    Additional mRNA sequence: BC074990.2 

    1 DOTS entry:

    DT.91678539 

    2 AceView cDNA sequences:

    BC069165 CA309199 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCGACCA
    KCNA10 Expression
    About this image


    KCNA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    KCNA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNA10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248140

    UniProtKB/Swiss-Prot: KCA10_HUMAN, Q16322
    Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and
    in smooth muscle cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNA10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcna101 , 5 potassium voltage-gated channel, shaker-related subfamily, more1, 5 88.78(n)1
    93.74(a)1
      3 (46.64 cM)5
    2421511  NM_001081140.11  NP_001074609.11 
     1071830565 
    chicken
    (Gallus gallus)
    Aves KCNA101 potassium voltage-gated channel, shaker-related subfamily, more 76.84(n)
    77.89(a)
      395116  NM_204462.1  NP_989793.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNA106
    potassium voltage-gated channel, shaker-related su...
    74(a)
    1 ↔ 1
    4(106714598-106716169)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcna101 potassium voltage-gated channel, shaker-related subfamily, more 68.55(n)
    74.4(a)
      100497698  XM_002938435.1  XP_002938481.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003295151 potassium voltage-gated channel subfamily A member more 67.79(n)
    72.3(a)
      100329515  XM_002667273.2  XP_002667319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3 courtship behavior voltage-gated
    potassium channel
    66(a)     --


    ENSEMBL Gene Tree for KCNA10 (if available)
    TreeFam Gene Tree for KCNA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNA10 gene
    KCNA62  KCNC22  KCNA22  KCNC42  KCND22  KCND12  KCNA72  KCNA52  
    KCNA12  KCNC12  KCNA42  KCNC32  KCNA32  KCND32  
    Selected SIMAP similar genes for KCNA10 using alignment to 1 protein entry:     KCA10_HUMAN(see all similar genes):
    KCNA1    KCNA3    KCNA4    KCNA7    KCNA5    KCNA2
    KCNA6    KCNB1    KCNB2    KCND1    KCND3    KCNC2
    KCNS2    KCNC1    KCND2    KCNS1    KCNC4    KCNF1

    KCNA10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNA10 (see all 189)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0367784
    A colorectal cancer sample4--see VAR_0367782 R H mis40--------
    rs1397208771,2
    --111059380(+) TTGCTC/GACAGC 1 -- ds50010--------
    rs12811761,2
    C,F--111059424(-) GTTTTG/TGTCTT 1 -- ds50016Minor allele frequency- T:0.20NA WA EA 364
    rs1921523711,2
    --111059712(+) ACATTC/TTGATC 1 -- ds50010--------
    rs1497925481,2
    C--111059715(+) TTTTGA/GTCTTT 1 -- ds50010--------
    rs1822118341,2
    C--111059717(+) TTGATC/TTTTGG 1 -- ds50010--------
    rs1860018291,2
    --111059723(+) TTTGGA/GAAGAT 1 -- ds50010--------
    rs2021678501,2
    --111059737(+) ATGAG-/AGAAGGGA 1 -- ds50010--------
    rs2020290111,2
    --111059738(+) TGAGA-/GAAG  
            
    GGAGA
    1 -- ds50010--------
    rs38418461,2
    C--111059812(-) TCTCT-/TCTCTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KCNA10 (111059839 - 111061797 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNA10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNA10
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNA10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602420    OMIM disorders: --

    10 diseases for KCNA10:    
    About MalaCards
    long qt syndrome    breast and colorectal cancer    tonsillitis    type 1 diabetes
    neuronitis    cerebritis    thyroiditis    colorectal cancer
    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for KCNA10:
    Long QT syndrome

    KCNA10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNA10
    Human Genome Epidemiology (HuGE) Navigator: KCNA10 (3 documents)

    Export disorders for KCNA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNA10 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KCNA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PubMed id 12444201)1, 2, 9 Yao X.... Desir G.V. (J. Am. Soc. Nephrol. 2002)
    2. KCNA10: a novel ion channel functionally related to both voltage- gated potassium and CNG cation channels. (PubMed id 10836990)1, 2, 9 Lang R....Desir G.V. (Am. J. Physiol. 2000)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    5. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PubMed id 12060596)1, 2 Tian S.... Desir G.V. (Am. J. Physiol. 2002)
    6. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. (PubMed id 9177773)1, 2 Orias M.... Desir G.V. (Genomics 1997)
    7. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)4 Scott L.J....Boehnke M. (Science 2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3744 HGNC: 6219 AceView: KCNA10.1 Ensembl:ENSG00000143105 euGenes: HUgn3744
    ECgene: KCNA10 H-InvDB: KCNA10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNA10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNA10 gene:
    Search GeneIP for patents involving KCNA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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