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KCNA1 Gene

protein-coding GIFtS: 63

GC12P004894

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AEMK)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AEMK ^², ⁵
EA1 ^², ⁵
HBK1 ^², ³
HUK1 ^¹, ²
HUKI ^³
KV1.1 ^²
Kv1.1 ^¹
MBK1 ^¹, ²
MGC126782 ^²
MGC138385 ^²
MK1 ^²
RBK1 ^¹, ²

Descriptions
Voltage-gated potassium channel subunit Kv1.1 ^², ³
potassium voltage-gated channel subfamily A member 1 ^²
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) ^²

External Ids
HGNC: 6218¹
Entrez Gene: 3736²
UniProtKB: Q09470³
Ensembl: ENSG00000111262⁷

Search outside databases for aliases for KCNA1 gene

Previous GC identifers: GC12P004758 GC12P004912 GC12P004891 GC12P004892

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNA1:

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the

Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6),

and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif

(GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with

beta subunits that can modify the inactivation properties of the channel as well as affect

expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is

responsible for channel targeting. Mutations in this gene have been associated with myokymia with

periodic ataxia (AEMK). [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNA1_HUMAN, Q09470

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNA1 gene

Entrez Gene cytogenetic band: 12p13.32 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13

KCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P004894: (about GC identifiers)

Start:	4,889,334 bp from pter
End:	4,897,683 bp from pter
Size:	8,350 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNA1_HUMAN, Q09470 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily A member 1

Size: 495 amino acids; 56466 Da

Subunit: Heterotetramer of potassium channel proteins. Binds KCNAB2 and PDZ domains of DLG1, DLG2

and DLG4 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Rna editing: Modified_positions=400; Note=Partially edited. RNA editing varies from 17% in the

caudate nucleus to 68% in the spinal cord and to 77% in the medulla

PDB structures from and Proteopedia :

2AFL (3D)

Secondary accessions: A6NM83 Q3MIQ9

Post-translational modifications:

Palmitoylated on Cys-243; which may be required for membrane targeting¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000208.2

ENSEMBL proteins:

ENSP00000371985 ENSP00000228858

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KCNA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kv1.1 potassium channel)
	Human Recombinant Proteins from Abnova (KCNA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	8845167
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for KCNA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNA1
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kv1.1 potassium channel), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNA1)
	Novus Biologicals Antibody for KCNA1

Assays for KCNA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q09470

ProtoNet protein and cluster: Q09470

4 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003972 Skaker voltage-gated K+ channel family signature

IPB004048 Kv1.1 voltage-gated K+ channel signature

UniProtKB/Swiss-Prot: KCNA1_HUMAN, Q09470

Domain: The N-terminus may be important in determining the rate of inactivation of the channel

while the tail may play a role in modulation of channel activity and/or targeting of the channel

to specific subcellular compartments

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. A (Shaker) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000217

Applied Biosystems Silencer® siRNAs for KCNA1

Sigma-Aldrich siRNA and siRNA Panels for KCNA1

Sigma-Aldrich shRNA Panels and shRNA for KCNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNA1
		Millipore Clones for the Expression of KCNA1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000217
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000217
untagged cDNA clone in CMV expression vector: NM_000217

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000217

UniProtKB/Swiss-Prot: KCNA1_HUMAN, Q09470

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane,

the protein forms a potassium-selective channel through which potassium ions may pass in

accordance with their electrochemical gradient

Genatlas biochemistry entry for KCNA1:

potassium voltage-gated channel,Drosophila shaker-related subfamily,member 1 (mouse Kv1.1

homolog),localized in terminal and juxtaparanodal regions of neurons

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcna1):

behavior/neurological	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	touch/vibrissae
vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005251	delayed rectifier potassium channel activity	TAS	8845167
GO:0005515	protein binding	IEA	--
GO:0015079	potassium ion transmembrane transporter activity	TAS	8845167
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNA1

5/55 Interacting proteins for KCNA1 (ENSP00000228858³ Q09470²) via UniProtKB, MINT, and/or STRING (see all 55 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352²	STRING (score=.968) MINT-1900376 MINT-1901225
KCNH2	ENSP00000262186³	STRING (score=.984)
KCNE1	ENSP00000337255³	STRING (score=.977)
KCNAB2	ENSP00000367323³	STRING (score=.968)
KCNA4	ENSP00000328511³	STRING (score=.963)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	8845167
GO:0007268	synaptic transmission	TAS	7842011

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNA1

Sigma-Aldrich Small Molecules for KCNA1:

Inhibitor

Compounds for KCNA1 available from Tocris Bioscience

Compound	Action	CAS number
DPO-1	Blocker of KV1.5 channel and IKur current	[43077-30-1]
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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1 Novoseek chemical compound relationship for KCNA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	75.05	26	17136396 (2), 10355668 (2), 7842011 (1), 7620586 (1) (see all 21)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000217

Sigma-Aldrich siRNA and siRNA Panels for KCNA1

Sigma-Aldrich shRNA Panels and shRNA for KCNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000217

REFSEQ mRNAs for KCNA1 gene:

NM_000217.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000217

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000217
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000217
                                 untagged cDNA clone in CMV expression vector: NM_000217

Additional cDNA sequence:

AK094760.1 AK124568.1 BC101733.1 BC112180.1 L02750.1

2 DOTS entries:

DT.309759 DT.91710590

7 AceView cDNA sequences:

BX283298 L02750 H41110 AW197476 BI117089 NM_000217 H18086

highest scoring ESTs for KCNA1:

L02750 AI694783 AW197476 BI117089 H41110 AA018118 AA018120 AA018214 AA057369 BE218939

Unigene Cluster for KCNA1:

Potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Hs.416139 [show with all ESTs]

Unigene Representative Sequence: NM_000217

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000382545 ENST00000228858

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNA1

¹ / ² / ³

7 probe-sets matching KCNA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44759_at²^{, 3}	U95-B	1	1.00	1.00	0.97	0.78	N64750	0.40	1.00	0.76	1
33939_at²^{, 3}	U95-A	1	1.00	1.00	0.62	0.35	L02750	1.00	1.00	1.00	1
71206_at²^{, 3}	U95-D	1	0.88	1.00	0.42	1.28	AI916293	0.40	0.75	0.60	1
208479_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000217	0.60	1.00	0.82	1
230849_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N64750	0.40	1.00	0.76	1
208479_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230849_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNA1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCTAATAG

SOURCE GeneReport for Unigene cluster: Hs.416139
Expression variation in blood from EXPOLDB for KCNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNA1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNA1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	96.36(n) 98.79(a)	486732 XM_543859.2 XP_543859.1
chimpanzee (Pan troglodytes)	KCNA1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	99.39(n) 99.8(a)	466928 XM_522328.2 XP_522328.2
cow (Bos taurus)	KCNA1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	93.4(n) 96.57(a)	538703 XM_582110.2 XP_582110.1
rat (Rattus norvegicus)	Kcna1¹	--	potassium voltage-gated channel, shaker-related subfamily, more	92.86(n) 98.18(a)	24520 NM_173095.2 NP_775118.1
mouse (Mus musculus)	Kcna1^{1, 5}	6 (61.00 cM)⁵	potassium voltage-gated channel, shaker-related subfamily, more^{1, 5}	93.33(n)¹ 98.38(a)¹	16485¹ NM_010595.3¹ NP_034725.3¹ AI840627⁵ AK033074⁵ (see all 10)

About this table Species with no ortholog for KCNA1

ENSEMBL Gene Tree for KCNA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNA1 gene

KCNA6² KCNA2² KCNA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/49 NCBI SNPs in KCNA1 are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2240865^1,2	A,C,F,H,O	4897914(-)	`TTCCAG/ATGGTC`	1	--	ng3¹		5		EA EU WA	1896
--	rs7974559^1,2	A,C,F,H	4894220(+)	`ACTGGT/ACATGA`	1	--	ut3¹		3		EU EA	300
--	rs7974459^1,2	A,C,F,H	4893974(+)	`AACTGC/TAGAAA`	1	--	ut3¹		3		EU EA	300
	rs4766311^1,2	A,C,F,H	4892699(+)	`AAATTT/CGCATG`	1	--	ut3¹		4		EU EA WA	418
--	rs1013783^1,2	A,C,F	4887377(-)	`CTCTTC/GTTCTT`	1	--	ng5¹		1		NA	84
	rs2229000^1,2	C,F,H	4891416(+)	`CCACCG/ACATCG`	1	H/R	mis¹ ese³		9		MN NA EA EU WA	784
	rs4766308^1,2	A,C,H	4889079(+)	`GCCGTG/TCGTGG`	1	--	ng5¹		4		EU EA WA	406
	rs12424292^1,2	A,C,F	4896732(+)	`ACTACC/TTGTAT`	1	--	ut3¹		4		NA EA	362
	rs4766310^1,2	A,C	4892302(+)	`ACAAAA/GGCAAG`	1	--	ut3¹		0	--	--	--	--
	rs10774289^1,2	A,C	4889130(+)	`GCTTTC/TCTGGT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KCNA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176260 disorders: 160120

UniProtKB/Swiss-Prot: KCNA1_HUMAN, Q09470

Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1) [MIM:160120]; also known as

paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is

an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria.

Neurological examination during and between the attacks demonstrates spontaneous, repetitive

discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is

absent

Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1) [MIM:160120]. Myokymia is

a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can

be observed as vermiform movement of the overlying skin. Electromyography typically shows

continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst

frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and

have no grave significance

10/12 Novoseek disease relationships for KCNA1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
episodic ataxia, type 1	94.35	5	10391459 (1), 11310626 (1), 16956965 (1), 17156368 (1) (see all 5)
neuromyotonia	83.12	4	12799903 (1), 15351427 (1), 16956965 (1), 17140792 (1)
familial benign neonatal convulsions	71.36	1	11579435 (1)
spinocerebellar ataxia type 6	70.72	1	16100538 (1)
myoclonic epilepsy juvenile	67.11	2	16100538 (1), 17008177 (1)
spinocerebellar ataxias	61.63	1	7762567 (1)
epilepsy generalized	60.83	3	16100538 (1), 17008177 (1), 11579435 (1)
epilepsy frontal lobe	58.61	2	17008177 (1), 11579435 (1)
neurological disorders	56.03	3	7620586 (1), 10391459 (1), 9714564 (1)
seizures febrile	42.77	2	17008177 (1), 11579435 (1)

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Human Gene Mutation Database: KCNA1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/79 PubMed articles for KCNA1 gene (see all 79 ):

Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. (PubMed id 7842011)^{1, 3, 4} Browne D.L.... Litt M. (1994)
Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. (PubMed id 17136396)^{1, 3, 4} Chen H....Hisama F.M. (2007)
A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. (PubMed id 10355668)^{1, 3, 4} Zuberi S.M....Hanna M.G. (1999)
Three novel KCNA1 mutations in episodic ataxia type I families. (PubMed id 9600245)^{1, 3, 4} Scheffer H.... Buys C.H.C.M. (1998)
Molecular cloning, characterization, and genomic localization of a human potassium channel gene. (PubMed id 1349297)^{1, 2, 3} Curran M.E.... Keating M.T. (1992)
Episodic ataxia and myokymia syndrome: a new mutation of potassium channel gene Kv1.1. (PubMed id 8871592)^{1, 3, 4} Comu S.... Narayanan V. (1996)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence. (PubMed id 15837928)^{3, 4} Gubitosi-Klug R.A.... Gross R.W. (2005)
A novel mutation in KCNA1 causes episodic ataxia without myokymia. (PubMed id 15532032)^{3, 4} Lee H.... Nelson S.F. (2004)
Nervous system targets of RNA editing identified by comparative genomics. (PubMed id 12907802)^{3, 4} Hoopengardner B.... Reenan R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3736	HGNC: 6218	AceView: KCNA1	Ensembl:ENSG00000111262	euGenes: HUgn3736
ECgene: KCNA1	H-InvDB: KCNA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=KCNA1

Licensable Technologies for KCNA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNA1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNA1		Small molecules for KCNA1
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	Antibodies		Primer Pairs
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Antibodies for KCNA1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KCNA1 Gene at Home site.
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KCNA1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for KCNA1

Summaries
for KCNA1

Genomic Location
for KCNA1

Proteins
for KCNA1

Protein Domains/
Families
for KCNA1

Gene Function
for KCNA1

Pathways & Interactions
for KCNA1

Drugs & Compounds
for KCNA1

Transcripts
for KCNA1

Expression
for KCNA1

Orthologs
for KCNA1

Paralogs
for KCNA1

SNPs/Variants
for KCNA1

Disorders & Mutations
for KCNA1

Medical News
for KCNA1

Publications
for KCNA1

Search for KCNA1

Genome Databases showing KCNA1

Other Databases showing KCNA1

Specialized Databases showing KCNA1

Licensable Technologies
for KCNA1

Services
for KCNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNA1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor KCNA1

Summariesfor KCNA1

Genomic Locationfor KCNA1

Proteinsfor KCNA1

Protein Domains/Familiesfor KCNA1

Gene Functionfor KCNA1

Pathways & Interactionsfor KCNA1

Drugs & Compoundsfor KCNA1

Transcriptsfor KCNA1

Expression for KCNA1

Orthologsfor KCNA1

Paralogsfor KCNA1

SNPs/Variantsfor KCNA1

Disorders & Mutationsfor KCNA1

Medical Newsfor KCNA1

Publicationsfor KCNA1

Search for KCNA1

Genome Databases showing KCNA1

Other Databases showing KCNA1

Specialized Databases showing KCNA1

Licensable Technologiesfor KCNA1

Servicesfor KCNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNA1

Summaries
for KCNA1

Genomic Location
for KCNA1

Proteins
for KCNA1

Protein Domains/
Families
for KCNA1

Gene Function
for KCNA1

Pathways & Interactions
for KCNA1

Drugs & Compounds
for KCNA1

Transcripts
for KCNA1

Expression
for KCNA1

Orthologs
for KCNA1

Paralogs
for KCNA1

SNPs/Variants
for KCNA1

Disorders & Mutations
for KCNA1

Medical News
for KCNA1

Publications
for KCNA1

Licensable Technologies
for KCNA1

Services
for KCNA1