Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCMF1 Gene

Aliases for KCMF1 Gene

  • Potassium Channel Modulatory Factor 1 2 3
  • ZZ-Type Zinc Finger-Containing Protein 1 3 4
  • FGF-Induced In Gastric Cancer 3 4
  • FIGC 3 4
  • PCMF 3 4
  • ZZZ1 3 4
  • FGF-Induced Ubiquitin-Protein Ligase In Gastric Cancers 3
  • Differentially Expressed In Branching Tubulogenesis 91 3
  • Zinc Finger, ZZ Domain Containing 1 3
  • Potassium Channel Modulatory Factor 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • DEBT91 3

External Ids for KCMF1 Gene

Previous GeneCards Identifiers for KCMF1 Gene

  • GC02P085155
  • GC02P085173
  • GC02P085109
  • GC02P085051
  • GC02P085198

Summaries for KCMF1 Gene

GeneCards Summary for KCMF1 Gene

KCMF1 (Potassium Channel Modulatory Factor 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for KCMF1 Gene

  • Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCMF1 Gene

Genomics for KCMF1 Gene

Regulatory Elements for KCMF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCMF1 Gene

Chromosome:
2
Start:
84,971,093 bp from pter
End:
85,059,472 bp from pter
Size:
88,380 bases
Orientation:
Plus strand

Genomic View for KCMF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCMF1 Gene

Proteins for KCMF1 Gene

  • Protein details for KCMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0J7-KCMF1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase KCMF1
    Protein Accession:
    Q9P0J7
    Secondary Accessions:
    • Q4ZG04
    • Q53SC7
    • Q9BWK2
    • Q9H8P5
    • Q9UFE8

    Protein attributes for KCMF1 Gene

    Size:
    381 amino acids
    Molecular mass:
    41945 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88897.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KCMF1 Gene

Proteomics data for KCMF1 Gene at MOPED

Post-translational modifications for KCMF1 Gene

  • Ubiquitination at Lys 14
  • Modification sites at PhosphoSitePlus

Other Protein References for KCMF1 Gene

Antibody Products

Domains & Families for KCMF1 Gene

Gene Families for KCMF1 Gene

Protein Domains for KCMF1 Gene

Suggested Antigen Peptide Sequences for KCMF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0J7

UniProtKB/Swiss-Prot:

KCMF1_HUMAN :
  • Belongs to the KCMF1 family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the KCMF1 family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with KCMF1: view

Function for KCMF1 Gene

Molecular function for KCMF1 Gene

UniProtKB/Swiss-Prot Function:
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
UniProtKB/Swiss-Prot Induction:
Up-regulated by FGF2 in gastric cancer cells.

Enzyme Numbers (IUBMB) for KCMF1 Gene

Gene Ontology (GO) - Molecular Function for KCMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with KCMF1: view
genes like me logo Genes that share phenotypes with KCMF1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCMF1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for KCMF1 Gene

Localization for KCMF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCMF1 Gene COMPARTMENTS Subcellular localization image for KCMF1 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCMF1 Gene

Pathways & Interactions for KCMF1 Gene

genes like me logo Genes that share pathways with KCMF1: view

Interacting Proteins for KCMF1 Gene

Gene Ontology (GO) - Biological Process for KCMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KCMF1: view

No data available for SIGNOR curated interactions for KCMF1 Gene

Drugs & Compounds for KCMF1 Gene

No Compound Related Data Available

Transcripts for KCMF1 Gene

Unigene Clusters for KCMF1 Gene

Potassium channel modulatory factor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCMF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCMF1 Gene

No ASD Table

Relevant External Links for KCMF1 Gene

GeneLoc Exon Structure for
KCMF1
ECgene alternative splicing isoforms for
KCMF1

Expression for KCMF1 Gene

mRNA expression in normal human tissues for KCMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCMF1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for KCMF1 Gene

This gene is overexpressed in Heart (29.5), Peripheral blood mononuclear cells (8.4), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCMF1 Gene



SOURCE GeneReport for Unigene cluster for KCMF1 Gene Hs.654968

mRNA Expression by UniProt/SwissProt for KCMF1 Gene

Q9P0J7-KCMF1_HUMAN
Tissue specificity: Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver.
genes like me logo Genes that share expression patterns with KCMF1: view

Protein tissue co-expression partners for KCMF1 Gene

Primer Products

In Situ Assay Products

Orthologs for KCMF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCMF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCMF1 35
  • 96.85 (n)
  • 99.21 (a)
KCMF1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475773 35
  • 97.96 (n)
  • 99.2 (a)
KCMF1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcmf1 35
  • 94.05 (n)
  • 97.38 (a)
Kcmf1 16
Kcmf1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCMF1 35
  • 99.65 (n)
  • 99.47 (a)
KCMF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcmf1 35
  • 94.4 (n)
  • 97.11 (a)
oppossum
(Monodelphis domestica)
Mammalia KCMF1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCMF1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCMF1 35
  • 90.03 (n)
  • 94.49 (a)
-- 36
  • 93 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KCMF1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.810 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7328 35
zebrafish
(Danio rerio)
Actinopterygii kcmf1 35
  • 78.04 (n)
  • 89.24 (a)
zgc64160 35
kcmf1 36
  • 90 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12246 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002670 35
  • 54.78 (n)
  • 61.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11984 36
  • 36 (a)
OneToMany
CG15286 36
  • 18 (a)
OneToMany
CG31642 36
  • 13 (a)
OneToMany
CG31835 36
  • 23 (a)
OneToMany
CG3526 36
  • 32 (a)
OneToMany
CG42585 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK652.6 36
  • 22 (a)
OneToOne
Species with no ortholog for KCMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCMF1 Gene

ENSEMBL:
Gene Tree for KCMF1 (if available)
TreeFam:
Gene Tree for KCMF1 (if available)

Paralogs for KCMF1 Gene

(1) SIMAP similar genes for KCMF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCMF1: view

No data available for Paralogs for KCMF1 Gene

Variants for KCMF1 Gene

Sequence variations from dbSNP and Humsavar for KCMF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1192837 -- 85,008,397(+) atata(A/T)tatat intron-variant
rs1192838 -- 85,023,388(-) tgagc(C/T)gagat intron-variant
rs1947785 -- 84,974,075(+) CACCC(A/G)CCTTG intron-variant
rs2127078 -- 85,030,941(-) gcagg(C/T)agatc intron-variant
rs2169863 -- 85,031,014(-) ctggc(A/T)taaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCMF1 Gene

Variant ID Type Subtype PubMed ID
dgv4201n71 CNV Loss 21882294
nsv834279 CNV Loss 17160897
esv2720288 CNV Deletion 23290073
esv5336 CNV Deletion 18987735
esv2720289 CNV Deletion 23290073
esv2720290 CNV Deletion 23290073

Variation tolerance for KCMF1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCMF1 Gene

HapMap Linkage Disequilibrium report
KCMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCMF1 Gene

Disorders for KCMF1 Gene

Relevant External Links for KCMF1

Genetic Association Database (GAD)
KCMF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCMF1
genes like me logo Genes that share disorders with KCMF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCMF1 Gene

Publications for KCMF1 Gene

  1. FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. (PMID: 15581609) Jang J.-H. (FEBS Lett. 2004) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1. (PMID: 24980667) Luo R. … Wang Y.L. (Hypertension 2014) 67

Products for KCMF1 Gene

Sources for KCMF1 Gene

Back to Top

Content