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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCMF1 Gene

protein-coding   GIFtS: 51
GCID: GC02P085198

Potassium Channel Modulatory Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel Modulatory Factor 11 2     Differentially Expressed In Branching Tubulogenesis 912
FIGC2 3     E3 Ubiquitin-Protein Ligase KCMF12
PCMF2 3     FGF-Induced Ubiquitin-Protein Ligase In Gastric Cancers2
ZZZ12 3     Zinc Finger, ZZ Domain Containing 12
FGF-Induced In Gastric Cancer2 3     EC 6.3.2.-3
ZZ-Type Zinc Finger-Containing Protein 12 3     Potassium Channel Modulatory Factor3
DEBT912     EC 6.3.28

External Ids:    HGNC: 205891   Entrez Gene: 568882   Ensembl: ENSG000001764077   OMIM: 6147195   UniProtKB: Q9P0J73   

Export aliases for KCMF1 gene to outside databases

Previous GC identifers: GC02P085155 GC02P085173 GC02P085109 GC02P085051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCMF1 Gene: 
KCMF1 (potassium channel modulatory factor 1) is a protein-coding gene. Diseases associated with KCMF1 include gastric cancer, and maturity-onset diabetes of the young, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include zinc ion binding and ligase activity.

UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCMF1 gene promoter:
         c-Fos   USF1   AP-1   USF2   CUTL1   LCR-F1   POU3F2   GATA-6   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCMF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCMF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

KCMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCMF1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085198:  view genomic region     (about GC identifiers)

Start:
85,198,216 bp from pter      End:
85,286,595 bp from pter
Size:
88,380 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase KCMF1  
Size: 381 amino acids; 41945 Da
Sequence caution: Sequence=AAX88897.1; Type=Erroneous initiation;
Secondary accessions: Q4ZG04 Q53SC7 Q9BWK2 Q9H8P5 Q9UFE8

Explore the universe of human proteins at neXtProt for KCMF1: NX_Q9P0J7

Explore proteomics data for KCMF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P0J7

  • 4/6 DME Specific Peptides for KCMF1 (Q9P0J7) (see all 6)
     SQFLLTRLN  NMHFTSSSTGGLSSSQSS  ADFGAMGCVDIMPLDVALE  ESERADRSLFVQELLLSTL 

    KCMF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCMF1 Protein Expression
    REFSEQ proteins: NP_064507.3  
    ENSEMBL proteins: 
     ENSP00000414214   ENSP00000386738   ENSP00000409499   ENSP00000391340  

    Human Recombinant Protein Products for KCMF1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZZZ: Zinc fingers, ZZ-type

    4 InterPro protein domains:
     IPR008598 Di19_RING_finger_144
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry Q9P0J7

    ProtoNet protein and cluster: Q9P0J7

    1 Blocks protein domain: IPB000433 Zn-finger

    UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
    Similarity: Belongs to the KCMF1 family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 ZZ-type zinc finger


    KCMF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMF1_HUMAN, Q9P0J7
    Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination
    Induction: Up-regulated by FGF2 in gastric cancer cells

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    KCMF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCMF1:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcmf1):
     endocrine/exocrine gland  mortality/aging  tumorigenesis 

    KCMF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCMF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCMF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCMF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCMF1 

    miRNA
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    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KCMF1 (see all 215):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-361-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of KCMF1

    Clone
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    OriGene ORF clones in mouse, rat for KCMF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of KCMF1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCMF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCMF1 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCMF1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for KCMF1 (Q9P0J73 ENSP000003867384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873I2D: score=2 
    GBASO753233I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCMF1

    Search CenterWatch for drugs/clinical trials and news about KCMF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCMF1 gene: 
    NM_020122.4  

    Unigene Cluster for KCMF1:

    Potassium channel modulatory factor 1
    Hs.654968  [show with all ESTs]
    Unigene Representative Sequence: NM_020122
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456682 ENST00000409785(uc002sox.4) ENST00000428691 ENST00000453448

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCMF1
    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KCMF1 (see all 215):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-361-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCMF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCMF1
    Clone
    Products:
         
    OriGene clones in human, mouse for KCMF1 (see all 8)
    OriGene ORF clones in mouse, rat for KCMF1
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    GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1
    Sirion Biotech Customized lentivirus for stable overexpression of KCMF1 
                         Customized lentivirus expression plasmids for stable overexpression of KCMF1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCMF1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCMF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCMF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCMF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCMF1

    Additional mRNA sequence: 

    AB083199.1 AF131740.1 AF155652.1 AK023403.1 AK311099.1 AK314761.1 AL122115.1 BC000178.2 

    10 DOTS entries:

    DT.85105570  DT.435421  DT.102824014  DT.65287093  DT.100792772  DT.95168284  DT.100792768  DT.100792769 
    DT.75146766  DT.95168286 

    24/229 AceView cDNA sequences (see all 229):

    BM476532 AK023403 CR607426 BM976843 AL544647 CR619076 BM700474 AA778328 
    CA396812 CR617449 BE858220 BU171579 BM824773 AF131740 BM759090 BE018000 
    CD677198 CA489095 AA831279 BM705865 BQ017681 BM667841 AA369285 BE904985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCMF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAGGCTC
    KCMF1 Expression
    About this image


    See KCMF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCMF1

    SOURCE GeneReport for Unigene cluster: Hs.654968

    UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
    Tissue specificity: Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low
    levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver

        SABiosciences Custom PCR Arrays for KCMF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCMF1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcmf11 , 5 potassium channel modulatory factor 11, 5 94.05(n)1
    97.38(a)1
      6 (32.30 cM)5
    742871  NM_019715.21  NP_062689.21 
     728411145 
    chicken
    (Gallus gallus)
    Aves KCMF11 potassium channel modulatory factor 1 90.03(n)
    94.49(a)
      770239  XM_001233571.2  XP_001233572.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCMF16
    potassium channel modulatory factor 1
    97(a)
    1 ↔ 1
    GL343339.1(1030725-1088282)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73282 Xenopus laevis transcribed sequence with strong similarity more 86.03(n)    CD327279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641602 similar to potassium channel modulatory factor 1 81.89(n)   393927  BC053288.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119841 CG11984 59.03(n)
    69.17(a)
      41082  NM_001170089.1  NP_001163560.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK652.66
    Uncharacterized protein ZK652.6
    18(a)
    1 ↔ 1
    III(7829409-7832504)


    ENSEMBL Gene Tree for KCMF1 (if available)
    TreeFam Gene Tree for KCMF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCMF1 gene
    1 SIMAP similar gene for KCMF1 using alignment to 3 protein entries:     KCMF1_HUMAN (see all proteins):
    ZNF313

    KCMF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1731 SNPs in KCMF1 are shown (see all 1731)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823563011,2
    --85196236(+) GACTGA/CAAAAA 1 -- us2k10--------
    rs2012032251,2
    --85196245(+) AAATG-/AAGT  
            
    AACTG
    1 -- us2k10--------
    rs1131014491,2
    C,F--85196867(+) TAACAA/GTCTTT 1 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs1506222871,2
    --85196888(+) CTGTGC/TTAGGT 1 -- us2k10--------
    rs1153083501,2
    C,F--85196889(+) TGTGCT/CAGGTA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1116713751,2
    C,F--85196904(+) ATATGT/CATTTT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1493345241,2
    --85197018(+) CAAATA/GGTGGA 1 -- us2k10--------
    rs798219731,2
    C,F--85197172(+) GGAGGC/TTCAGC 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1445255761,2
    --85197198(+) TCCACG/TGTTAC 1 -- us2k10--------
    rs1172931721,2
    C,F--85197302(+) GTAAGG/AGGCAG 1 -- us2k11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for KCMF1 (85198216 - 85286595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KCMF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv5336CNV Deletion18987735
    esv2720290CNV Deletion23290073
    esv2720289CNV Deletion23290073
    esv2720288CNV Deletion23290073
    nsv834279CNV Loss17160897
    dgv4201n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCMF1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCMF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614719    OMIM disorders: --

    7 diseases for KCMF1:    About MalaCards
    gastric cancer    maturity-onset diabetes of the young    cholera    sarcoma
    hepatitis    prostatitis    neuronitis


    KCMF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCMF1

    Export disorders for KCMF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCMF1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with KCMF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. (PubMed id 15581609)1, 2, 9 Jang J.-H. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    5. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56888 HGNC: 20589 AceView: KCMF1 Ensembl:ENSG00000176407 euGenes: HUgn56888
    ECgene: KCMF1 H-InvDB: KCMF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KCMF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCMF1 gene:
    Search GeneIP for patents involving KCMF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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