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KCMF1 Gene

protein-coding   GIFtS: 52
GCID: GC02P085198

Potassium Channel Modulatory Factor 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Modulatory Factor 11 2     Differentially Expressed In Branching Tubulogenesis 912
FIGC2 3 5     E3 Ubiquitin-Protein Ligase KCMF12
PCMF2 3     FGF-Induced Ubiquitin-Protein Ligase In Gastric Cancers2
ZZZ12 3     Zinc Finger, ZZ Domain Containing 12
FGF-Induced In Gastric Cancer2 3     EC 6.3.2.-3
ZZ-Type Zinc Finger-Containing Protein 12 3     Potassium Channel Modulatory Factor3
DEBT912 5     EC 6.3.28

External Ids:    HGNC: 205891   Entrez Gene: 568882   Ensembl: ENSG000001764077   OMIM: 6147195   UniProtKB: Q9P0J73   

Export aliases for KCMF1 gene to outside databases

Previous GC identifers: GC02P085155 GC02P085173 GC02P085109 GC02P085051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCMF1 Gene:
KCMF1 (potassium channel modulatory factor 1) is a protein-coding gene. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCMF1 gene promoter:
         c-Fos   USF1   AP-1   USF2   CUTL1   LCR-F1   POU3F2   GATA-6   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCMF1 promoter sequence
   Search Chromatin IP Primers for KCMF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

KCMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCMF1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085198:  view genomic region     (about GC identifiers)

Start:
85,198,216 bp from pter      End:
85,286,595 bp from pter
Size:
88,380 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase KCMF1  
Size: 381 amino acids; 41945 Da
Sequence caution: Sequence=AAX88897.1; Type=Erroneous initiation;
Secondary accessions: Q4ZG04 Q53SC7 Q9BWK2 Q9H8P5 Q9UFE8

Explore the universe of human proteins at neXtProt for KCMF1: NX_Q9P0J7

Explore proteomics data for KCMF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KCMF1 (Q9P0J7) (see all 6)
     SQFLLTRLN  NMHFTSSSTGGLSSSQSS  ADFGAMGCVDIMPLDVALE  ESERADRSLFVQELLLSTL 


    See KCMF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064507.3  
    ENSEMBL proteins: 
     ENSP00000414214   ENSP00000386738   ENSP00000409499   ENSP00000391340  

    KCMF1 Human Recombinant Protein Products:

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    Novus Biologicals KCMF1 Protein
    Novus Biologicals KCMF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCMF1

     
    Search eBioscience for Proteins for KCMF1 

     
    antibodies-online proteins for KCMF1 (7 products) 

     
    antibodies-online peptides for KCMF1

    KCMF1 Antibody Products:

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    ThermoFisher Antibodies for KCMF1
    LSBio Antibodies in human, mouse, rat for KCMF1
    antibodies-online antibodies for KCMF1 (16 products) 

    KCMF1 Assay Products:

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    Cloud-Clone Corp. ELISAs for KCMF1
    Cloud-Clone Corp. CLIAs for KCMF1
    Search eBioscience for ELISAs for KCMF1 
    antibodies-online kits for KCMF1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZZZ: Zinc fingers, ZZ-type

    4 InterPro protein domains:
     IPR008598 Di19_Zn_binding
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry Q9P0J7

    ProtoNet protein and cluster: Q9P0J7

    1 Blocks protein domain: IPB000433 Zn-finger

    UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
    Similarity: Belongs to the KCMF1 family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 ZZ-type zinc finger


    Find genes that share domains with KCMF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMF1_HUMAN, Q9P0J7
    Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination
    Induction: Up-regulated by FGF2 in gastric cancer cells

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with KCMF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCMF1:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcmf1):
     endocrine/exocrine gland  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with KCMF1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCMF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCMF1
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    miRNA
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    Block miRNA regulation of human, mouse, rat KCMF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCMF1 (see all 215):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-361-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCMF1
    Predesigned siRNA for gene silencing in human, mouse, rat KCMF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122)
    Sino Biological Human cDNA Clone for KCMF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCMF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCMF1 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCMF1
    Interactions:

        Search GeneGlobe Interaction Network for KCMF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for KCMF1 (Q9P0J73 ENSP000003867384) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873I2D: score=2 
    GBASO753233I2D: score=1 
    NR2E1ENSP000003579824STRING: ENSP00000357982
    UBCENSP000003448184STRING: ENSP00000344818
    ATP6V1E1ENSP000002534134STRING: ENSP00000253413
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCMF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCMF1 gene: 
    NM_020122.4  

    Unigene Cluster for KCMF1:

    Potassium channel modulatory factor 1
    Hs.654968  [show with all ESTs]
    Unigene Representative Sequence: NM_020122
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456682 ENST00000409785(uc002sox.4) ENST00000428691 ENST00000453448

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCMF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCMF1 (see all 215):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-361-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCMF1
    Predesigned siRNA for gene silencing in human, mouse, rat KCMF1
    Clone
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    OriGene clones in human, mouse for KCMF1 (see all 7)
    OriGene ORF clones in mouse, rat for KCMF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCMF1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCMF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCMF1
      QuantiTect SYBR Green Assays in human, mouse, rat KCMF1
      QuantiFast Probe-based Assays in human, mouse, rat KCMF1

    Additional mRNA sequence: 

    AB083199.1 AF131740.1 AF155652.1 AK023403.1 AK311099.1 AK314761.1 AL122115.1 BC000178.2 

    10 DOTS entries:

    DT.85105570  DT.435421  DT.102824014  DT.65287093  DT.100792772  DT.95168284  DT.100792768  DT.100792769 
    DT.75146766  DT.95168286 

    Selected AceView cDNA sequences (see all 229):

    BE904985 BM476532 CA396812 BM824773 AK023403 CR619076 CR617449 BQ017681 
    CA489095 BU633231 BM705865 AL544647 CR607426 BM781874 BU171579 AF131740 
    BM700474 BM976843 AA831279 BE018000 CD677198 BM759090 BE858220 BI868238 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCMF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAGGCTC
    KCMF1 Expression
    About this image


    KCMF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    KCMF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCMF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654968

    UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7
    Tissue specificity: Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low
    levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCMF1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcmf11 , 5 potassium channel modulatory factor 11, 5 94.05(n)1
    97.38(a)1
      6 (32.30 cM)5
    742871  NM_019715.21  NP_062689.21 
     728411145 
    chicken
    (Gallus gallus)
    Aves KCMF11 potassium channel modulatory factor 1 90.03(n)
    94.49(a)
      770239  XM_001233571.3  XP_001233572.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCMF16
    potassium channel modulatory factor 1
    97(a)
    1 ↔ 1
    GL343339.1(1030725-1088282)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73282 Xenopus laevis transcribed sequence with strong similarity more 86.03(n)    CD327279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641602 similar to potassium channel modulatory factor 1 81.89(n)   393927  BC053288.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119846
    CG35266
    (see all 6)
    --
    36(a)
    32(a)
    (see all 6)
    many → 1
    many → 1
    (see all 6)
    3R(4836004-4840631)
    X(2784801-2788265)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK652.66
    Protein ZK652.6, isoform a
    22(a)
    1 ↔ 1
    III(7829411-7832504) WBGene00022785


    ENSEMBL Gene Tree for KCMF1 (if available)
    TreeFam Gene Tree for KCMF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCMF1 gene
    1 SIMAP similar gene for KCMF1 using alignment to 3 protein entries:     KCMF1_HUMAN (see all proteins):
    ZNF313

    Find genes that share paralogs with KCMF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCMF1 (see all 1731)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823563011,2
    --85196236(+) GACTGA/CAAAAA 1 -- us2k10--------
    rs2012032251,2
    --85196245(+) AAATG-/AAGT  
            
    AACTG
    1 -- us2k10--------
    rs1131014491,2
    C,F--85196867(+) TAACAA/GTCTTT 1 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs1506222871,2
    --85196888(+) CTGTGC/TTAGGT 1 -- us2k10--------
    rs1153083501,2
    C,F--85196889(+) TGTGCT/CAGGTA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1116713751,2
    C,F--85196904(+) ATATGT/CATTTT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1493345241,2
    --85197018(+) CAAATA/GGTGGA 1 -- us2k10--------
    rs798219731,2
    C,F--85197172(+) GGAGGC/TTCAGC 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1445255761,2
    --85197198(+) TCCACG/TGTTAC 1 -- us2k10--------
    rs1172931721,2
    C,F--85197302(+) GTAAGG/AGGCAG 1 -- us2k11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for KCMF1 (85198216 - 85286595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KCMF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5336CNV Deletion18987735
    esv2720290CNV Deletion23290073
    esv2720289CNV Deletion23290073
    esv2720288CNV Deletion23290073
    nsv834279CNV Loss17160897
    dgv4201n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCMF1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCMF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614719    OMIM disorders: --


    Find genes that share disorders with KCMF1           About GenesLikeMe

    Genetic Association Database (GAD): KCMF1

    Export disorders for KCMF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCMF1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with KCMF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. (PubMed id 15581609)1, 2, 9 Jang J.-H. (FEBS Lett. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56888 HGNC: 20589 AceView: KCMF1 Ensembl:ENSG00000176407 euGenes: HUgn56888
    ECgene: KCMF1 H-InvDB: KCMF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KCMF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCMF1 gene:
    Search GeneIP for patents involving KCMF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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