KCMF1 Gene
protein-coding GIFtS: 50
GCID: GC02P085198
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potassium channel modulatory factor 1
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Aliases
for KCMF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Modulatory Factor 11 2 | | Differentially Expressed In Branching Tubulogenesis 912 | | PCMF1 2 3 | | E3 Ubiquitin-Protein Ligase KCMF12 | | ZZZ11 2 3 | | FGF-Induced Ubiquitin-Protein Ligase In Gastric Cancers2 | | DEBT911 2 | | Zinc Finger, ZZ Domain Containing 12 | | FIGC2 3 | | EC 6.3.2.-3 | | FGF-Induced In Gastric Cancer2 3 | | Potassium Channel Modulatory Factor3 | | ZZ-Type Zinc Finger-Containing Protein 12 3 | | EC 6.3.28 | | DKFZP434L10211 | | |
Export aliases for KCMF1 gene to outside databasesPrevious GC identifers: GC02P085155 GC02P085173 GC02P085109 GC02P085051 |
Summaries
for KCMF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination
|
Genomic Views
for KCMF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCMF1 gene promoter:
c-Fos USF1 AP-1 USF2 CUTL1 LCR-F1 POU3F2 GATA-6 c-Jun Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCMF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCMF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2KCMF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P085198: view genomic region
(about GC identifiers)
Start:
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85,198,216 bp from pter |
End:
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85,286,595 bp from pter |
Size:
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88,380 bases |
Orientation:
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plus strand |
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Proteins
for KCMF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase KCMF1 Size: 381 amino acids; 41945 Da
Sequence caution: Sequence=AAX88897.1; Type=Erroneous initiation;
Secondary accessions: Q4ZG04 Q53SC7 Q9BWK2 Q9H8P5 Q9UFE8Explore the universe of human proteins at neXtProt for KCMF1: NX_Q9P0J7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0J7
4/6 DME Specific Peptides for KCMF1 (Q9P0J7) (see all 6)
KCMF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064507.3
ENSEMBL proteins: ENSP00000414214 ENSP00000386738 ENSP00000409499 ENSP00000391340
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
KCMF1 for ontologies About GeneDecksing
KCMF1 Antibody Products:
Assay Products for KCMF1: |
Protein
Domains /
Families
for KCMF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCMF1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0J7ProtoNet protein and cluster: Q9P0J7 1 Blocks protein family: IPB000433 Zn-finger
UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7Similarity: Belongs to the KCMF1 familySimilarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 1 ZZ-type zinc finger |
Function
for KCMF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7Function: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitinationInduction: Up-regulated by FGF2 in gastric cancer cellsEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCMF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- |
KCMF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KCMF1:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Kcmf1):
KCMF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCMF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | |
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCMF1 (see all 13)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCMF1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for KCMF1 (Q9P0J73 ENSP000003867384) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KCMF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCMF1
Search CenterWatch for drugs/clinical trials and news about KCMF1
|
Transcripts
for KCMF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCMF1 gene: NM_020122.4 Unigene Cluster for KCMF1: Potassium channel modulatory factor 1 Hs.654968 [show with all ESTs]Unigene Representative Sequence: NM_0201224 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000456682 ENST00000409785(uc002sox.4) ENST00000428691 ENST00000453448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCMF1 (NM_020122) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCMF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1 |
Additional cDNA sequence: AB083199.1 AF131740.1 AF155652.1 AK023403.1 AK311099.1 AK314761.1 AL122115.1 BC000178.2 10 DOTS entries: DT.85105570 DT.435421 DT.102824014 DT.65287093 DT.100792772 DT.95168284 DT.100792768 DT.100792769 DT.75146766 DT.95168286 24/229 AceView cDNA sequences (see all 229): CA489095 BM759090 BM476532 CD677198 BE018000 AA831279 BE858220 BI868238 BM824773 BM976843 AA778328 BU171579 CR619076 AL544647 CR617449 AF131740 BM705865 CR607426 CA396812 BM781874 BM700474 BU633231 AK023403 BM667841
GeneLoc Exon Structure
|
Expression
for KCMF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCMF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAAGGCTC
About this image
See KCMF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCMF1
SOURCE GeneReport for Unigene cluster: Hs.654968
UniProtKB/Swiss-Prot: KCMF1_HUMAN, Q9P0J7Tissue specificity: Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at lowlevels in the thymus, prostate, testis, colon, heart, brain, placenta and liver
SABiosciences Custom PCR Arrays for KCMF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCMF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCMF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCMF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCMF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1 |
Orthologs
for KCMF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCMF1 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for KCMF1 (if available)
TreeFam Gene Tree for KCMF1 (if available) |
Paralogs
for KCMF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KCMF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCMF1 (85198216 - 85286595 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCMF1
1 Indel: 41503 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCMF1 |
|
Disorders
/ Diseases
for KCMF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCMF1 for disorders About GeneDecksing
OMIM gene information: 614719
OMIM disorders: --
3  diseases for KCMF1: About MalaCardsgastric cancer sarcoma prostatitis
Export disorders for KCMF1 gene to outside databases
|
Publications
for KCMF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCMF1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with KCMF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. (PubMed id 15581609)1, 2, 9 Jang J.-H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for KCMF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCMF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCMF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCMF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCMF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCMF1 gene:
Search GeneIP for patents involving KCMF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCMF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCMF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCMF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCMF1 | | | OriGene Protein Over-expression Lysate for KCMF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCMF1 | | OriGene 3'-UTR Clone for KCMF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCMF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KCMF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCMF1 | | OriGene Custom Protein Services for KCMF1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCMF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCMF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCMF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCMF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCMF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCMF1 |
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| | | | Search Tocris compounds for KCMF1 |
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 | | | KCMF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCMF1 |
|  |  |  | | | | ThermoFisher Antibodies for KCMF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCMF1 |
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