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Aliases for KBTBD8 Gene

Aliases for KBTBD8 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 8 2 3
  • T-Cell Activation Kelch Repeat Protein 2 3 4
  • TA-KRP 3 4
  • Kelch Repeat And BTB Domain-Containing Protein 8 3
  • KIAA1842 4
  • TAKRP 4

External Ids for KBTBD8 Gene

Summaries for KBTBD8 Gene

GeneCards Summary for KBTBD8 Gene

KBTBD8 (Kelch Repeat And BTB (POZ) Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD8 Gene

Genomics for KBTBD8 Gene

Genomic Location for KBTBD8 Gene

Start:
66,998,303 bp from pter
End:
67,011,210 bp from pter
Size:
12,908 bases
Orientation:
Plus strand

Genomic View for KBTBD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD8 Gene

Regulatory Elements for KBTBD8 Gene

Proteins for KBTBD8 Gene

  • Protein details for KBTBD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFY9-KBTB8_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 8
    Protein Accession:
    Q8NFY9
    Secondary Accessions:
    • B4DTW6
    • Q96JI5

    Protein attributes for KBTBD8 Gene

    Size:
    601 amino acids
    Molecular mass:
    68823 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM43839.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KBTBD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KBTBD8 Gene

Proteomics data for KBTBD8 Gene at MOPED

Post-translational modifications for KBTBD8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys268

Other Protein References for KBTBD8 Gene

No data available for DME Specific Peptides for KBTBD8 Gene

Domains for KBTBD8 Gene

Gene Families for KBTBD8 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Graphical View of Domain Structure for InterPro Entry

Q8NFY9

UniProtKB/Swiss-Prot:

KBTB8_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q8NFY9
  • Contains 1 BTB (POZ) domain.:
    • Q8NFY9
Similarity:
  • Contains 5 Kelch repeats.:
    • Q8NFY9
genes like me logo Genes that share domains with KBTBD8: view

Function for KBTBD8 Gene

Gene Ontology (GO) - Molecular Function for KBTBD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD8: view

miRNA for KBTBD8 Gene

miRTarBase miRNAs that target KBTBD8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KBTBD8 Gene

Localization for KBTBD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KBTBD8 Gene

Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KBTBD8 Gene COMPARTMENTS Subcellular localization image for KBTBD8 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KBTBD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with KBTBD8: view

Pathways for KBTBD8 Gene

SuperPathways for KBTBD8 Gene

No Data Available

Interacting Proteins for KBTBD8 Gene

Gene Ontology (GO) - Biological Process for KBTBD8 Gene

None

No data available for Pathways by source for KBTBD8 Gene

Transcripts for KBTBD8 Gene

Unigene Clusters for KBTBD8 Gene

Kelch repeat and BTB (POZ) domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - - - - -
SP3: - -
SP4:

Relevant External Links for KBTBD8 Gene

GeneLoc Exon Structure for
KBTBD8
ECgene alternative splicing isoforms for
KBTBD8

Expression for KBTBD8 Gene

mRNA expression in normal human tissues for KBTBD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KBTBD8 Gene

SOURCE GeneReport for Unigene cluster for KBTBD8 Gene Hs.116665

genes like me logo Genes that share expressions with KBTBD8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KBTBD8 Gene

Orthologs for KBTBD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KBTBD8 35
  • 99.78 (n)
  • 99.83 (a)
KBTBD8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KBTBD8 35
  • 94.01 (n)
  • 98.17 (a)
KBTBD8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KBTBD8 35
  • 94.51 (n)
  • 97 (a)
KBTBD8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kbtbd8 35
  • 93.04 (n)
  • 97.83 (a)
Kbtbd8 16
Kbtbd8 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KBTBD8 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KBTBD8 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kbtbd8 35
  • 92.51 (n)
  • 97.67 (a)
chicken
(Gallus gallus)
Aves KBTBD8 35
  • 85.97 (n)
  • 89.35 (a)
KBTBD8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KBTBD8 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13285 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd8 35
  • 76.2 (n)
  • 78.93 (a)
zebrafish
(Danio rerio)
Actinopterygii kbtbd8 35
  • 69.33 (n)
  • 74 (a)
kbtbd8 36
  • 73 (a)
OneToOne
wufc57a10 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for KBTBD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD8 Gene

ENSEMBL:
Gene Tree for KBTBD8 (if available)
TreeFam:
Gene Tree for KBTBD8 (if available)

Paralogs for KBTBD8 Gene

genes like me logo Genes that share paralogs with KBTBD8: view

Variants for KBTBD8 Gene

Sequence variations from dbSNP and Humsavar for KBTBD8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2364281 -- 66,999,779(-) CATTT(A/C)AACAA intron-variant
rs4856833 -- 66,998,338(+) TGGAG(C/T)CGGGG utr-variant-5-prime
rs6549565 -- 67,004,720(+) ATTCT(A/G)TGGAA intron-variant
rs6549575 -- 67,011,536(+) atggc(A/G)gaggg downstream-variant-500B
rs6549576 -- 67,011,594(+) ttcct(C/G)tctct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KBTBD8 Gene

Variant ID Type Subtype PubMed ID
nsv508220 CNV Loss 20534489

Relevant External Links for KBTBD8 Gene

HapMap Linkage Disequilibrium report
KBTBD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD8 Gene

Disorders for KBTBD8 Gene

Relevant External Links for KBTBD8

Genetic Association Database (GAD)
KBTBD8
Human Genome Epidemiology (HuGE) Navigator
KBTBD8
genes like me logo Genes that share disorders with KBTBD8: view

No data available for UniProtKB/Swiss-Prot for KBTBD8 Gene

Publications for KBTBD8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for KBTBD8 Gene

Sources for KBTBD8 Gene

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