KBTBD7 Gene
protein-coding GIFtS: 47
GCID: GC13M041765
|
|
kelch repeat and BTB (POZ) domain containing 7
| |
Aliases
for KBTBD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch Repeat And BTB (POZ) Domain Containing 71 2 | | DKFZP434E23181 | | Kelch Repeat And BTB Domain-Containing Protein 72 |
Export aliases for KBTBD7 gene to outside databasesPrevious GC identifers: GC13M039563 GC13M040663 GC13M022565 |
Summaries
for KBTBD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for KBTBD7
|
Genomic Views
for KBTBD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KBTBD7 gene promoter:
AhR E2F-4 E2F-3a E2F-5 E2F-2 LCR-F1 Tal-1beta E2F E2F-1 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KBTBD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KBTBD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3KBTBD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M041765: view genomic region
(about GC identifiers)
Start:
|
41,763,969 bp from pter |
End:
|
41,768,702 bp from pter |
Size:
|
4,734 bases |
Orientation:
|
minus strand |
|
Proteins
for KBTBD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KBTB7_HUMAN, Q8WVZ9 (See
protein sequence)Recommended Name: Kelch repeat and BTB domain-containing protein 7 Size: 684 amino acids; 77163 Da
Secondary accessions: B5TZ86 Q5T6Y7 Q8NB99 Q9H0I6Explore the universe of human proteins at neXtProt for KBTBD7: NX_Q8WVZ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVZ9
KBTBD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115514.2
ENSEMBL proteins: ENSP00000368797
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
KBTBD7 for ontologies About GeneDecksing
KBTBD7 Antibody Products:
Assay Products for KBTBD7: |
Protein
Domains /
Families
for KBTBD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KBTBD7 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8WVZ9ProtoNet protein and cluster: Q8WVZ9 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KBTB7_HUMAN, Q8WVZ9Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 Kelch repeats |
Function
for KBTBD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KBTBD7 (NM_032138) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KBTBD7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005515 | protein binding |
IPI | -- |
KBTBD7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KBTBD7:
|
Pathways & Interactions
for KBTBD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KBTBD7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/556 Interacting proteins for KBTBD7 (Q8WVZ91, 2, 3 ENSP000003687974) via UniProtKB, MINT, STRING, and/or I2D (see all 556)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
KBTBD7 for ontologies About GeneDecksing
|
Drugs & Compounds
for KBTBD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KBTBD7
Search CenterWatch for drugs/clinical trials and news about KBTBD7 / KBTB7
|
Transcripts
for KBTBD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KBTBD7 gene: NM_032138.4 Unigene Cluster for KBTBD7: Kelch repeat and BTB (POZ) domain containing 7 Hs.63841 [show with all ESTs]Unigene Representative Sequence: BC0220331 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000379483(uc001uxw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KBTBD7 (NM_032138) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KBTBD7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD7 |
Additional cDNA sequence: AK091344.1 AK299614.1 AK315589.1 AL136782.1 BC022033.2 CR533558.1 FJ150424.1 5 DOTS entries: DT.100738699 DT.210442 DT.100801329 DT.120794104 DT.40192958 24/102 AceView cDNA sequences (see all 102): BU069965 BF589011 BF436101 BC022033 AA334052 AW572436 BQ024653 NM_032138 CB158659 AA383657 BP376706 BF110230 AI340297 BI491779 AI820566 AI819513 BU070208 AA376738 BF432075 AI312909 BF591650 AI277867 AI631319 AW955761
GeneLoc Exon Structure
|
Expression
for KBTBD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KBTBD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATCGACCT
About this image
See KBTBD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KBTBD7
SOURCE GeneReport for Unigene cluster: Hs.63841
SABiosciences Expression via Pathway-Focused PCR Array including KBTBD7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KBTBD7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KBTBD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KBTBD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KBTBD7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD7 |
Orthologs
for KBTBD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KBTBD7 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for KBTBD7 (if available)
TreeFam Gene Tree for KBTBD7 (if available) |
Paralogs
for KBTBD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KBTBD7 gene
- KBTBD122 KLHL402 KLHL72 KBTBD22 KBTBD82 KLHL412 KBTBD62
5 SIMAP similar genes for KBTBD7 using alignment to 2 protein entries: KBTB7_HUMAN (see all proteins):KBTBD6 KLHL17 KBTBD3 KLHL20 KLHL32
KBTBD7 for paralogs About GeneDecksing
|
Genomic Variants
for KBTBD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KBTBD7 (41763969 - 41768702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KBTBD7
1 CNV: 4799 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KBTBD7 |
|
Disorders
/ Diseases
for KBTBD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KBTBD7 for disorders About MalaCards
KBTBD7 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: KBTBD7 (1 document)
Export disorders for KBTBD7 gene to outside databases
|
Publications
for KBTBD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KBTBD7 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with KBTBD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- KBTBD7, a novel human BTB-kelch protein, activates tr anscriptional activities of SRE and AP-1. (PubMed id 20132730)1 Hu J....Wu X. (2010)
|
External Searches for KBTBD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KBTBD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KBTBD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KBTBD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KBTBD7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KBTBD7 gene:
Search GeneIP for patents involving KBTBD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KBTBD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KBTBD7 | | OriGene shRNA RFP for KBTBD7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KBTBD7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KBTBD7 | | | OriGene Protein Over-expression Lysate for KBTBD7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KBTBD7 | | OriGene 3'-UTR Clone for KBTBD7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KBTBD7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KBTBD7 | | OriGene Custom Protein Services for KBTBD7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KBTBD7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KBTBD7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KBTBD7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KBTBD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KBTBD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KBTBD7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KBTBD7 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KBTBD7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD7 |
|  |  |  | | | | Search ThermoFisher Antibodies for KBTBD7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD7 |
|
|
|
|
