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Aliases for KBTBD7 Gene

Aliases for KBTBD7 Gene

  • Kelch Repeat And BTB Domain Containing 7 2 3
  • Kelch Repeat And BTB (POZ) Domain Containing 7 2 5

External Ids for KBTBD7 Gene

Previous GeneCards Identifiers for KBTBD7 Gene

  • GC13M039563
  • GC13M040663
  • GC13M041765
  • GC13M022565

Summaries for KBTBD7 Gene

GeneCards Summary for KBTBD7 Gene

KBTBD7 (Kelch Repeat And BTB Domain Containing 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. An important paralog of this gene is KBTBD8.

Gene Wiki entry for KBTBD7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD7 Gene

Genomics for KBTBD7 Gene

Regulatory Elements for KBTBD7 Gene

Promoters for KBTBD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KBTBD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for KBTBD7 Gene

Chromosome:
13
Start:
41,189,833 bp from pter
End:
41,194,566 bp from pter
Size:
4,734 bases
Orientation:
Minus strand

Genomic View for KBTBD7 Gene

Genes around KBTBD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD7 Gene

Proteins for KBTBD7 Gene

  • Protein details for KBTBD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVZ9-KBTB7_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 7
    Protein Accession:
    Q8WVZ9
    Secondary Accessions:
    • B5TZ86
    • Q5T6Y7
    • Q8NB99
    • Q9H0I6

    Protein attributes for KBTBD7 Gene

    Size:
    684 amino acids
    Molecular mass:
    77163 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KBTBD7 Gene

Proteomics data for KBTBD7 Gene at MOPED

Post-translational modifications for KBTBD7 Gene

  • Ubiquitination at Lys 187, Lys 201, Lys 403, Lys 452, Lys 511, and Lys 535
  • Modification sites at PhosphoSitePlus

Other Protein References for KBTBD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD7 Gene

Domains & Families for KBTBD7 Gene

Gene Families for KBTBD7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVZ9

UniProtKB/Swiss-Prot:

KBTB7_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 5 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KBTBD7: view

Function for KBTBD7 Gene

genes like me logo Genes that share phenotypes with KBTBD7: view

Animal Model Products

miRNA for KBTBD7 Gene

miRTarBase miRNAs that target KBTBD7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD7 Gene

Localization for KBTBD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KBTBD7 Gene COMPARTMENTS Subcellular localization image for KBTBD7 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for KBTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KBTBD7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KBTBD7 Gene

Pathways & Interactions for KBTBD7 Gene

SuperPathways for KBTBD7 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 CDK-mediated phosphorylation and removal of Cdc6
genes like me logo Genes that share pathways with KBTBD7: view

Pathways by source for KBTBD7 Gene

Gene Ontology (GO) - Biological Process for KBTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KBTBD7: view

No data available for SIGNOR curated interactions for KBTBD7 Gene

Drugs & Compounds for KBTBD7 Gene

No Compound Related Data Available

Transcripts for KBTBD7 Gene

mRNA/cDNA for KBTBD7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(102) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD7 Gene

Kelch repeat and BTB (POZ) domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD7 Gene

No ASD Table

Relevant External Links for KBTBD7 Gene

GeneLoc Exon Structure for
KBTBD7
ECgene alternative splicing isoforms for
KBTBD7

Expression for KBTBD7 Gene

mRNA expression in normal human tissues for KBTBD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KBTBD7 Gene

This gene is overexpressed in Pancreas (44.4) and Retina (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KBTBD7 Gene



SOURCE GeneReport for Unigene cluster for KBTBD7 Gene Hs.63841

genes like me logo Genes that share expression patterns with KBTBD7: view

Protein tissue co-expression partners for KBTBD7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KBTBD7 Gene

Orthologs for KBTBD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KBTBD7 35
  • 90.39 (n)
  • 96.32 (a)
-- 36
  • 96 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia KBTBD7 35
  • 89.05 (n)
  • 94.7 (a)
-- 36
  • 95 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Kbtbd7 35
  • 88.87 (n)
  • 95.29 (a)
Kbtbd7 16
Kbtbd7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KBTBD7 35
  • 99.71 (n)
  • 100 (a)
KBTBD7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd7 35
  • 67.17 (n)
  • 69.23 (a)
Str.2171 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15710 35
zebrafish
(Danio rerio)
Actinopterygii kbtbd7 35
  • 58.38 (n)
  • 54 (a)
kbtbd7 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for KBTBD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD7 Gene

ENSEMBL:
Gene Tree for KBTBD7 (if available)
TreeFam:
Gene Tree for KBTBD7 (if available)

Paralogs for KBTBD7 Gene

Paralogs for KBTBD7 Gene

(5) SIMAP similar genes for KBTBD7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KBTBD7: view

Variants for KBTBD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for KBTBD7 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV Gain 17160897
esv2747299 CNV Deletion 23290073

Variation tolerance for KBTBD7 Gene

Residual Variation Intolerance Score: 9.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD7 Gene

HapMap Linkage Disequilibrium report
KBTBD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KBTBD7 Gene

Disorders for KBTBD7 Gene

Relevant External Links for KBTBD7

Genetic Association Database (GAD)
KBTBD7
Human Genome Epidemiology (HuGE) Navigator
KBTBD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KBTBD7

No disorders were found for KBTBD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD7 Gene

Publications for KBTBD7 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KBTBD7 Gene

Sources for KBTBD7 Gene

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