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KBTBD7 Gene

protein-coding GIFtS: 49

GC13M040663

kelch repeat and BTB (POZ) domain containing 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZP434E2318 ^¹
DKFZp434E2318 ^²
OTTHUMP00000018313 ^²

Descriptions
kelch repeat and BTB (POZ) domain containing 7 ^²
kelch repeat and BTB domain containing 7 ^¹

External Ids
HGNC: 25266¹
Entrez Gene: 84078²
UniProtKB: Q8WVZ9³
Ensembl: ENSG00000120696⁷

Search outside databases for aliases for KBTBD7 gene

Previous GC identifer: GC13M039563

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for KBTBD7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KBTBD7 gene

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3

KBTBD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M040663: (about GC identifiers)

Start:	40,661,969 bp from pter
End:	40,666,702 bp from pter
Size:	4,734 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KBTB7_HUMAN, Q8WVZ9 (See protein sequence)

Recommended Name: Kelch repeat and BTB domain-containing protein 7

Size: 684 amino acids; 77163 Da

Secondary accessions: Q5T6Y7 Q8NB99 Q9H0I6

REFSEQ proteins: NP_115514.2

ENSEMBL proteins:

ENSP00000368797

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KBTBD7)
	Human Recombinant Proteins from Abnova (KBTBD7)

OriGene Purified Recombinant Human Protein: KBTBD7

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for KBTBD7:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KBTBD7
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KBTBD7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KBTBD7)
	Novus Biologicals Antibodies for KBTBD7

Assays for KBTBD7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8WVZ9

ProtoNet protein and cluster: Q8WVZ9

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB011705 BTB/Kelch-associated

UniProtKB/Swiss-Prot: KBTB7_HUMAN, Q8WVZ9

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 5 Kelch repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032138

Applied Biosystems Silencer® siRNAs for KBTBD7

Sigma-Aldrich siRNA and siRNA Panels for KBTBD7

Sigma-Aldrich shRNA for KBTBD7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KBTBD7
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032138
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032138
untagged cDNA clone in CMV expression vector: NM_032138

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032138

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for KBTBD7 (Q8WVZ9²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
BARD1 Q99728² MINT-3978907
-- Q9PH0² MINT-3981186
-- Q9NV32² MINT-3980863
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KBTBD7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032138

Sigma-Aldrich siRNA and siRNA Panels for KBTBD7

Sigma-Aldrich shRNA for KBTBD7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032138

REFSEQ mRNAs for KBTBD7 gene:

NM_032138.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032138

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032138
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032138
                                 untagged cDNA clone in CMV expression vector: NM_032138

Additional cDNA sequence:

AK091344.1 AK299614.1 AK315589.1 AL136782.1 BC022033.2 CR533558.1 FJ150424.1

5 DOTS entries:

DT.100738699 DT.210442 DT.100801329 DT.120794104 DT.40192958

24/102 AceView cDNA sequences (see all 102 ):

BI491779 BF110230 BF432075 Z41269 AW955761 AI277867 CB158659 BU070208

AA334052 BU069965 AI312909 BC022033 BF591650 BF589011 AW572436 AI820566

BP376706 AA383657 AI340297 AI631319 BF436101 NM_032138 BQ024653 AI819513

highest scoring ESTs for KBTBD7:

AA334052 AA383657 AI340297 AI820566 AK091344 AL136782 AW955761 BC022033 BE176419 BE536232

Unigene Cluster for KBTBD7:

Kelch repeat and BTB (POZ) domain containing 7

Hs.63841 [show with all ESTs]

Unigene Representative Sequence: BC022033

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000379483

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KBTBD7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KBTBD7

¹ / ² / ³

9 probe-sets matching KBTBD7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62514_r_at²^{, 3}	U95-C	1	1.00	1.00	0.75	0.67	AI340297	0.80	1.00	0.91	1
46812_at²^{, 3}	U95-B	1	1.00	1.00	0.30	1.26	N78361	0.60	1.00	0.82	1
61129_at²^{, 3}	U95-C	1	1.00	1.00	0.80	1.09	N62595	0.40	1.00	0.76	1
229298_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF436101	0.40	1.00	0.76	1
223412_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL136782	0.80	1.00	0.91	1
229970_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BE672291	0.20	1.00	0.72	1
229298_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223412_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229970_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks KBTBD7 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AAATCGACCT

SOURCE GeneReport for Unigene cluster: Hs.63841

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KBTBD7 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KBTBD7¹	--	kelch repeat and BTB (POZ) domain containing 7	89.05(n) 94.7(a)	485467 XM_542586.2 XP_542586.1
chimpanzee (Pan troglodytes)	KBTBD7¹	--	kelch repeat and BTB (POZ) domain containing 7	99.71(n) 100(a)	467268 XM_522666.2 XP_522666.1
cow (Bos taurus)	KBTBD7¹	--	kelch repeat and BTB (POZ) domain containing 7	90.59(n) 96.47(a)	539110 XM_584893.3 XP_584893.1
mouse (Mus musculus)	Kbtbd7^{1, 5}	14⁵	kelch repeat and BTB (POZ) domain containing 7^{1, 5}	88.82(n)¹ 95.15(a)¹	211255¹ NM_001024135.1¹ NP_001019306.1¹ AK003597⁵ AK135854⁵ (see all 10)
zebrafish (Danio rerio)	LOC794299¹	--	similar to kelch repeat and BTB (POZ) domain containing more	58.71(n) 54.23(a)	794299 XM_001334195.2 XP_001334231.1

About this table Species with no ortholog for KBTBD7

ENSEMBL Gene Tree for KBTBD7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KBTBD7 gene

KLHDC6² KLHL11² KLHL38² KBTBD6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in KBTBD7 are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 24)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2151236^1,2	A,C,F,H	40667660(-)	`AGCATA/TGACTA`	1	--	ng3¹		11		EU EA WA NA	976
--	rs9525462^1,2	A,C,F,H	40666690(+)	`TAGGCG/CCCCGG`	1	--	ut5¹ ese³		4		EU EA WA	412
	rs9532739^1,2	A,H	40663464(+)	`TTCCTC/TTGAGT`	1	--	ng5¹ ese³		4		EU EA WA	420
--	rs17068726^1,2	F	40663725(+)	`AGCTTA/GTGAGG`	1	--	ut3¹ ese³		3		NA	138
	rs7339391^1,2	H	40666889(+)	`AGACtG/Cttgcc`	1	--	ng3¹		4		EU EA WA	420
--	rs2039135^1,2	A,C,F,H	40665341(+)	`CTAGGG/ATGTCC`	1	H/H	syn¹		6		EA NA EU WA	456
--	rs2039134^1,2	A,C,F,H	40665338(+)	`TCTCTA/GGGATG`	1	P/P	syn¹		2		EU WA	240
--	rs5803082^1,2	--	40663543(+)	`TTTTT-/TGGTTT`	1	--	ng5¹		0	--	--	--	--
--	rs71427468^1,2	--	40664925(+)	`TACTGG/TTGACA`	1	N/T	mis¹		0	--	--	--	--
--	rs71803680^1,2	--	40663535(+)	`TTTTT-/TTTTTT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KBTBD7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10 PubMed articles for KBTBD7 gene:

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)⁴ Dunham A.... Ross M.T. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84078	HGNC: 25266	AceView: KBTBD7	Ensembl:ENSG00000120696	euGenes: HUgn84078
ECgene: KBTBD7	H-InvDB: KBTBD7

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KBTBD7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KBTBD7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KBTBD7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KBTBD7		Antibodies for KBTBD7
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KBTBD7		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (KBTBD7)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for KBTBD7

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Antibodies for KBTBD7

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KBTBD7 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for KBTBD7

Summaries
for KBTBD7

Genomic Location
for KBTBD7

Proteins
for KBTBD7

Protein Domains/
Families
for KBTBD7

Gene Function
for KBTBD7

Pathways & Interactions
for KBTBD7

Drugs & Compounds
for KBTBD7

Transcripts
for KBTBD7

Expression
for KBTBD7

Orthologs
for KBTBD7

Paralogs
for KBTBD7

SNPs/Variants
for KBTBD7

Disorders & Mutations
for KBTBD7

Medical News
for KBTBD7

Publications
for KBTBD7

Search for KBTBD7

Genome Databases showing KBTBD7

Other Databases showing KBTBD7

Specialized Databases showing KBTBD7

Licensable Technologies
for KBTBD7

Services
for KBTBD7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KBTBD7 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor KBTBD7

Summariesfor KBTBD7

Genomic Locationfor KBTBD7

Proteinsfor KBTBD7

Protein Domains/Familiesfor KBTBD7

Gene Functionfor KBTBD7

Pathways & Interactionsfor KBTBD7

Drugs & Compoundsfor KBTBD7

Transcriptsfor KBTBD7

Expression for KBTBD7

Orthologsfor KBTBD7

Paralogsfor KBTBD7

SNPs/Variantsfor KBTBD7

Disorders & Mutationsfor KBTBD7

Medical Newsfor KBTBD7

Publicationsfor KBTBD7

Search for KBTBD7

Genome Databases showing KBTBD7

Other Databases showing KBTBD7

Specialized Databases showing KBTBD7

Licensable Technologiesfor KBTBD7

Servicesfor KBTBD7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KBTBD7

Summaries
for KBTBD7

Genomic Location
for KBTBD7

Proteins
for KBTBD7

Protein Domains/
Families
for KBTBD7

Gene Function
for KBTBD7

Pathways & Interactions
for KBTBD7

Drugs & Compounds
for KBTBD7

Transcripts
for KBTBD7

Expression
for KBTBD7

Orthologs
for KBTBD7

Paralogs
for KBTBD7

SNPs/Variants
for KBTBD7

Disorders & Mutations
for KBTBD7

Medical News
for KBTBD7

Publications
for KBTBD7

Licensable Technologies
for KBTBD7

Services
for KBTBD7