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Aliases for KBTBD6 Gene

Aliases for KBTBD6 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 6 2 3

External Ids for KBTBD6 Gene

Previous GeneCards Identifiers for KBTBD6 Gene

  • GC13M039501
  • GC13M040599
  • GC13M041701
  • GC13M022501

Summaries for KBTBD6 Gene

GeneCards Summary for KBTBD6 Gene

KBTBD6 (Kelch Repeat And BTB (POZ) Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is KLHL30.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD6 Gene

Genomics for KBTBD6 Gene

Regulatory Elements for KBTBD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KBTBD6 Gene

41,127,569 bp from pter
41,132,800 bp from pter
5,232 bases
Minus strand

Genomic View for KBTBD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD6 Gene

Proteins for KBTBD6 Gene

  • Protein details for KBTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T6Y8
    • Q8N8L0
    • Q8NDM5
    • Q96MP6

    Protein attributes for KBTBD6 Gene

    674 amino acids
    Molecular mass:
    76138 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KBTBD6 Gene

neXtProt entry for KBTBD6 Gene

Proteomics data for KBTBD6 Gene at MOPED

Post-translational modifications for KBTBD6 Gene

  • Ubiquitination at Lys263 and Lys289
  • Modification sites at PhosphoSitePlus

Other Protein References for KBTBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD6 Gene

Domains for KBTBD6 Gene

Gene Families for KBTBD6 Gene

  • BTBD :BTB/POZ domain containing

Protein Domains for KBTBD6 Gene

Suggested Antigen Peptide Sequences for KBTBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86V97
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KBTBD6: view

Function for KBTBD6 Gene

Gene Ontology (GO) - Molecular Function for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KBTBD6: view

Phenotypes for KBTBD6 Gene

GenomeRNAi human phenotypes for KBTBD6:
genes like me logo Genes that share phenotypes with KBTBD6: view

Animal Model Products

miRNA for KBTBD6 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KBTBD6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KBTBD6 Gene

Localization for KBTBD6 Gene

Subcellular locations from

Jensen Localization Image for KBTBD6 Gene COMPARTMENTS Subcellular localization image for KBTBD6 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KBTBD6 Gene

Pathways for KBTBD6 Gene

SuperPathways for KBTBD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Pathways by source for KBTBD6 Gene

Transcripts for KBTBD6 Gene

mRNA/cDNA for KBTBD6 Gene

(8) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD6 Gene

Kelch repeat and BTB (POZ) domain containing 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KBTBD6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD6 Gene

No ASD Table

Relevant External Links for KBTBD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD6 Gene

mRNA expression in normal human tissues for KBTBD6 Gene

Protein differential expression in normal tissues for KBTBD6 Gene

This gene is overexpressed in Urinary Bladder (62.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KBTBD6 Gene

SOURCE GeneReport for Unigene cluster for KBTBD6 Gene Hs.534040

genes like me logo Genes that share expressions with KBTBD6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for KBTBD6 Gene

Orthologs for KBTBD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KBTBD6 35
  • 85.86 (n)
  • 89.32 (a)
  • 89 (a)
(Canis familiaris)
Mammalia KBTBD6 35
  • 86.75 (n)
  • 91.69 (a)
  • 92 (a)
(Mus musculus)
Mammalia Zbtbd6 35
  • 82.74 (n)
  • 80.58 (a)
Zbtbd6 16
Zbtbd6 36
  • 70 (a)
(Pan troglodytes)
Mammalia KBTBD6 35
  • 99.7 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Kbtbd6 35
  • 82.53 (n)
  • 81.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Danio rerio)
Actinopterygii kbtbd7 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for KBTBD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD6 Gene

Gene Tree for KBTBD6 (if available)
Gene Tree for KBTBD6 (if available)

Paralogs for KBTBD6 Gene

Selected SIMAP similar genes for KBTBD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KBTBD6: view

Variants for KBTBD6 Gene

Sequence variations from dbSNP and Humsavar for KBTBD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1226 -- 41,127,707(+) CTAAG(C/T)TTTAA utr-variant-3-prime
rs1952591 -- 41,129,826(-) GCTGG(G/T)CGTGG utr-variant-3-prime
rs4053821 -- 41,129,681(+) TTTTT(-/TTTTT)GAGAC utr-variant-3-prime
rs9566702 -- 41,129,654(+) CTTTT(C/T)Ttttt utr-variant-3-prime
rs9594488 -- 41,128,985(+) AATAC(C/T)TTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KBTBD6 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV Gain 17160897
esv2747299 CNV Deletion 23290073

Relevant External Links for KBTBD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD6 Gene

Disorders for KBTBD6 Gene

No disorders were found for KBTBD6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KBTBD6 Gene

Publications for KBTBD6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PMID: 18247557) Jones J. … Huang L. (J. Proteome Res. 2008) 3
  5. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PMID: 19295130) Olma M.H. … Pintard L. (J. Cell. Sci. 2009) 3

Products for KBTBD6 Gene

Sources for KBTBD6 Gene

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