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Aliases for KBTBD6 Gene

Aliases for KBTBD6 Gene

  • Kelch Repeat And BTB Domain Containing 6 2 3
  • Kelch Repeat And BTB (POZ) Domain Containing 6 2 5

External Ids for KBTBD6 Gene

Previous GeneCards Identifiers for KBTBD6 Gene

  • GC13M039501
  • GC13M040599
  • GC13M041701
  • GC13M022501

Summaries for KBTBD6 Gene

GeneCards Summary for KBTBD6 Gene

KBTBD6 (Kelch Repeat And BTB Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is KBTBD8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD6 Gene

Genomics for KBTBD6 Gene

Regulatory Elements for KBTBD6 Gene

Promoters for KBTBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KBTBD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KBTBD6 Gene

Chromosome:
13
Start:
41,127,569 bp from pter
End:
41,132,800 bp from pter
Size:
5,232 bases
Orientation:
Minus strand

Genomic View for KBTBD6 Gene

Genes around KBTBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD6 Gene

Proteins for KBTBD6 Gene

  • Protein details for KBTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V97-KBTB6_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 6
    Protein Accession:
    Q86V97
    Secondary Accessions:
    • Q5T6Y8
    • Q8N8L0
    • Q8NDM5
    • Q96MP6

    Protein attributes for KBTBD6 Gene

    Size:
    674 amino acids
    Molecular mass:
    76138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KBTBD6 Gene

neXtProt entry for KBTBD6 Gene

Proteomics data for KBTBD6 Gene at MOPED

Post-translational modifications for KBTBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD6 Gene

Domains & Families for KBTBD6 Gene

Gene Families for KBTBD6 Gene

Protein Domains for KBTBD6 Gene

Suggested Antigen Peptide Sequences for KBTBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V97

UniProtKB/Swiss-Prot:

KBTB6_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KBTBD6: view

Function for KBTBD6 Gene

Gene Ontology (GO) - Molecular Function for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KBTBD6: view

Phenotypes for KBTBD6 Gene

GenomeRNAi human phenotypes for KBTBD6:
genes like me logo Genes that share phenotypes with KBTBD6: view

Animal Model Products

miRNA for KBTBD6 Gene

miRTarBase miRNAs that target KBTBD6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD6 Gene

Localization for KBTBD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KBTBD6 Gene COMPARTMENTS Subcellular localization image for KBTBD6 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KBTBD6 Gene

Pathways & Interactions for KBTBD6 Gene

SuperPathways for KBTBD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Pathways by source and SIGNOR curated interactions for KBTBD6 Gene

Drugs & Compounds for KBTBD6 Gene

No Compound Related Data Available

Transcripts for KBTBD6 Gene

mRNA/cDNA for KBTBD6 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD6 Gene

Kelch repeat and BTB (POZ) domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD6 Gene

No ASD Table

Relevant External Links for KBTBD6 Gene

GeneLoc Exon Structure for
KBTBD6
ECgene alternative splicing isoforms for
KBTBD6

Expression for KBTBD6 Gene

mRNA expression in normal human tissues for KBTBD6 Gene

Protein differential expression in normal tissues from HIPED for KBTBD6 Gene

This gene is overexpressed in Urinary Bladder (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KBTBD6 Gene



SOURCE GeneReport for Unigene cluster for KBTBD6 Gene Hs.534040

genes like me logo Genes that share expression patterns with KBTBD6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KBTBD6 Gene

Orthologs for KBTBD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KBTBD6 35
  • 99.7 (n)
  • 100 (a)
KBTBD6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KBTBD6 36
  • 89 (a)
OneToOne
KBTBD6 35
  • 85.86 (n)
  • 89.32 (a)
dog
(Canis familiaris)
Mammalia KBTBD6 35
  • 86.75 (n)
  • 91.69 (a)
KBTBD6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kbtbd6 16
Zbtbd6 36
  • 70 (a)
OneToOne
Zbtbd6 35
  • 82.74 (n)
  • 80.58 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kbtbd6 35
  • 82.53 (n)
  • 81.55 (a)
zebrafish
(Danio rerio)
Actinopterygii kbtbd7 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for KBTBD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD6 Gene

ENSEMBL:
Gene Tree for KBTBD6 (if available)
TreeFam:
Gene Tree for KBTBD6 (if available)

Paralogs for KBTBD6 Gene

Paralogs for KBTBD6 Gene

(6) SIMAP similar genes for KBTBD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KBTBD6: view

Variants for KBTBD6 Gene

Sequence variations from dbSNP and Humsavar for KBTBD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs4053821 -- 41,129,681(+) TTTTT(-/TTTTT)GAGAC utr-variant-3-prime
rs9566702 -- 41,129,654(+) CTTTT(C/T)Ttttt utr-variant-3-prime
rs9594488 -- 41,128,985(+) AATAC(C/T)TTCAA utr-variant-3-prime
rs34635680 -- 41,128,611(+) ATCCA(-/G)CTTAT utr-variant-3-prime
rs41286989 -- 41,127,779(+) TCTGC(A/T)GATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KBTBD6 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV Gain 17160897
esv2747299 CNV Deletion 23290073

Variation tolerance for KBTBD6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD6 Gene

HapMap Linkage Disequilibrium report
KBTBD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD6 Gene

Disorders for KBTBD6 Gene

Relevant External Links for KBTBD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KBTBD6

No disorders were found for KBTBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD6 Gene

Publications for KBTBD6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for KBTBD6 Gene

Sources for KBTBD6 Gene

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