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Aliases for KBTBD6 Gene

Aliases for KBTBD6 Gene

  • Kelch Repeat And BTB Domain Containing 6 2 3 5
  • Kelch Repeat And BTB (POZ) Domain Containing 6 2

External Ids for KBTBD6 Gene

Previous GeneCards Identifiers for KBTBD6 Gene

  • GC13M039501
  • GC13M040599
  • GC13M041701
  • GC13M022501

Summaries for KBTBD6 Gene

GeneCards Summary for KBTBD6 Gene

KBTBD6 (Kelch Repeat And BTB Domain Containing 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is KBTBD7.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD6 Gene

Genomics for KBTBD6 Gene

Regulatory Elements for KBTBD6 Gene

Enhancers for KBTBD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G040770 1.2 ENCODE 23.5 +361.7 361704 1.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 KBTBD6 LINC00548 ELF1 FOXO1 SUGT1P3 SLC25A15 MRPS31 ENSG00000277794
GH13G040788 1 ENCODE 10.7 +342.9 342939 2.7 PKNOX1 FOXA2 ARNT CREB3L1 ZFP64 SIN3A ZNF143 ZNF207 KLF13 SP3 SLC25A15 KBTBD6 MRPS31 PIR45478
GH13G040679 0.7 ENCODE 10.7 +452.8 452840 0.8 FOXA2 ZFP64 FOXA3 HLF ZNF140 ZNF426 ZNF394 ZBTB8A ZNF781 ZNF518A KBTBD6 SLC25A15 GC13P040667 GC13P040698
GH13G041188 0.4 ENCODE 13.2 -56.0 -55974 1.1 FOXA2 FOS KBTBD6 ELF1 WBP4 MTRF1 KBTBD7 CALM2P3
GH13G041128 0.5 Ensembl 0.7 +3.9 3900 0.6 ZNF121 PRDM6 MAFK ZBTB17 KBTBD6 RN7SL597P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KBTBD6 on UCSC Golden Path with GeneCards custom track

Promoters for KBTBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KBTBD6 Gene

41,127,569 bp from pter
41,132,800 bp from pter
5,232 bases
Minus strand

Genomic View for KBTBD6 Gene

Genes around KBTBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD6 Gene

Proteins for KBTBD6 Gene

  • Protein details for KBTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T6Y8
    • Q8N8L0
    • Q8NDM5
    • Q96MP6

    Protein attributes for KBTBD6 Gene

    674 amino acids
    Molecular mass:
    76138 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KBTBD6 Gene

neXtProt entry for KBTBD6 Gene

Post-translational modifications for KBTBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD6 Gene

Domains & Families for KBTBD6 Gene

Gene Families for KBTBD6 Gene

Suggested Antigen Peptide Sequences for KBTBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KBTBD6: view

No data available for UniProtKB/Swiss-Prot for KBTBD6 Gene

Function for KBTBD6 Gene

Gene Ontology (GO) - Molecular Function for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KBTBD6: view

Phenotypes for KBTBD6 Gene

GenomeRNAi human phenotypes for KBTBD6:
genes like me logo Genes that share phenotypes with KBTBD6: view

Animal Model Products

CRISPR Products

miRNA for KBTBD6 Gene

miRTarBase miRNAs that target KBTBD6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD6 Gene

Localization for KBTBD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KBTBD6 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KBTBD6 Gene

Pathways & Interactions for KBTBD6 Gene

genes like me logo Genes that share pathways with KBTBD6: view

Gene Ontology (GO) - Biological Process for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for SIGNOR curated interactions for KBTBD6 Gene

Transcripts for KBTBD6 Gene

mRNA/cDNA for KBTBD6 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD6 Gene

Kelch repeat and BTB (POZ) domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD6 Gene

No ASD Table

Relevant External Links for KBTBD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KBTBD6 Gene

Protein differential expression in normal tissues from HIPED for KBTBD6 Gene

This gene is overexpressed in Urinary Bladder (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KBTBD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of KBTBD6 Gene:


SOURCE GeneReport for Unigene cluster for KBTBD6 Gene:


Evidence on tissue expression from TISSUES for KBTBD6 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KBTBD6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KBTBD6 Gene

Orthologs for KBTBD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KBTBD6 34 35
  • 99.7 (n)
(Canis familiaris)
Mammalia KBTBD6 34 35
  • 86.75 (n)
(Bos Taurus)
Mammalia KBTBD6 34 35
  • 85.86 (n)
(Mus musculus)
Mammalia Zbtbd6 34 35
  • 82.74 (n)
Kbtbd6 16
(Rattus norvegicus)
Mammalia LOC100909827 34
  • 82.53 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Danio rerio)
Actinopterygii kbtbd7 35
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for KBTBD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD6 Gene

Gene Tree for KBTBD6 (if available)
Gene Tree for KBTBD6 (if available)

Paralogs for KBTBD6 Gene

(6) SIMAP similar genes for KBTBD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KBTBD6: view

Variants for KBTBD6 Gene

Sequence variations from dbSNP and Humsavar for KBTBD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000478238 -- 41,132,525(+) TGGCG(A/G)CGGGC upstream-variant-2KB, utr-variant-5-prime
rs1001045150 -- 41,129,122(+) ACAAT(A/G)ACTAC utr-variant-3-prime
rs1001494249 -- 41,129,449(+) TGACA(C/T)AACTA utr-variant-3-prime
rs1001729070 -- 41,132,896(+) AAAGA(A/G)TCCGC upstream-variant-2KB
rs1002281097 -- 41,133,311(+) AAAAC(A/C)CCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KBTBD6 Gene

Variant ID Type Subtype PubMed ID
esv2747299 CNV deletion 23290073
nsv832587 CNV gain 17160897
nsv974084 CNV duplication 23825009

Variation tolerance for KBTBD6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD6 Gene

Disorders for KBTBD6 Gene

Relevant External Links for KBTBD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KBTBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD6 Gene

Publications for KBTBD6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KBTBD6 Gene

Sources for KBTBD6 Gene

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