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Aliases for KBTBD6 Gene

Aliases for KBTBD6 Gene

  • Kelch Repeat And BTB Domain Containing 6 2 3 5
  • Kelch Repeat And BTB (POZ) Domain Containing 6 2

External Ids for KBTBD6 Gene

Previous GeneCards Identifiers for KBTBD6 Gene

  • GC13M039501
  • GC13M040599
  • GC13M041701
  • GC13M022501

Summaries for KBTBD6 Gene

GeneCards Summary for KBTBD6 Gene

KBTBD6 (Kelch Repeat And BTB Domain Containing 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is KBTBD7.

Additional gene information for KBTBD6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD6 Gene

Genomics for KBTBD6 Gene

Regulatory Elements for KBTBD6 Gene

Enhancers for KBTBD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H040770 1.2 ENCODE 23.5 +361.7 361704 1.9 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 LINC00548 KBTBD6 MORF4L1P4 ELF1 FOXO1 SUGT1P3 NAA16 SLC25A15 MRPS31 ENSG00000277794
GH13H040788 1 ENCODE 10.7 +342.9 342939 2.7 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ETS1 ELK1 ZNF143 ZNF207 ATF7 SLC25A15 KBTBD6 MRPS31 PIR45478
GH13H040679 0.6 ENCODE 10.7 +452.8 452840 0.8 ZFP64 ZC3H11A ZNF140 ZBTB8A ZNF781 ZNF518A ZNF697 PRDM12 ZNF548 NAA16 TPTE2P5 KBTBD6 CYCSP34 SLC25A15 GC13P040667 GC13P040698
GH13H041188 0.4 ENCODE 13.2 -56.0 -55974 1.1 FOXA2 FOS KBTBD6 ELF1 WBP4 MTRF1 KBTBD7 CALM2P3
GH13H041129 0.5 Ensembl 0.7 +3.3 3300 0.2 ZNF362 ZNF316 MAFG ZNF384 EMSY KBTBD6 RN7SL597P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KBTBD6 on UCSC Golden Path with GeneCards custom track

Promoters for KBTBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for KBTBD6 Gene

Genomic Locations for KBTBD6 Gene
5,232 bases
Minus strand

Genomic View for KBTBD6 Gene

Genes around KBTBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD6 Gene

Proteins for KBTBD6 Gene

  • Protein details for KBTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T6Y8
    • Q8N8L0
    • Q8NDM5
    • Q96MP6

    Protein attributes for KBTBD6 Gene

    674 amino acids
    Molecular mass:
    76138 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KBTBD6 Gene

neXtProt entry for KBTBD6 Gene

Post-translational modifications for KBTBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD6 Gene

Domains & Families for KBTBD6 Gene

Gene Families for KBTBD6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KBTBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KBTBD6: view

No data available for UniProtKB/Swiss-Prot for KBTBD6 Gene

Function for KBTBD6 Gene

Phenotypes From GWAS Catalog for KBTBD6 Gene

Gene Ontology (GO) - Molecular Function for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KBTBD6: view

Phenotypes for KBTBD6 Gene

GenomeRNAi human phenotypes for KBTBD6:
genes like me logo Genes that share phenotypes with KBTBD6: view

miRNA for KBTBD6 Gene

miRTarBase miRNAs that target KBTBD6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD6 Gene

Localization for KBTBD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KBTBD6 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KBTBD6 Gene

Pathways & Interactions for KBTBD6 Gene

genes like me logo Genes that share pathways with KBTBD6: view

Gene Ontology (GO) - Biological Process for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for SIGNOR curated interactions for KBTBD6 Gene

Drugs & Compounds for KBTBD6 Gene

No Compound Related Data Available

Transcripts for KBTBD6 Gene

mRNA/cDNA for KBTBD6 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD6 Gene

Kelch repeat and BTB (POZ) domain containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD6 Gene

No ASD Table

Relevant External Links for KBTBD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KBTBD6 Gene

Protein differential expression in normal tissues from HIPED for KBTBD6 Gene

This gene is overexpressed in Urinary Bladder (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KBTBD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of KBTBD6 Gene:


SOURCE GeneReport for Unigene cluster for KBTBD6 Gene:


Evidence on tissue expression from TISSUES for KBTBD6 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KBTBD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KBTBD6 Gene

Orthologs for KBTBD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KBTBD6 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia KBTBD6 33 34
  • 86.75 (n)
(Bos Taurus)
Mammalia KBTBD6 33 34
  • 85.86 (n)
(Mus musculus)
Mammalia Zbtbd6 34 33
  • 82.74 (n)
Kbtbd6 16
(Rattus norvegicus)
Mammalia Kbtbd6 33
  • 82.53 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Danio rerio)
Actinopterygii kbtbd7 34
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for KBTBD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD6 Gene

Gene Tree for KBTBD6 (if available)
Gene Tree for KBTBD6 (if available)

Paralogs for KBTBD6 Gene

Paralogs for KBTBD6 Gene

(6) SIMAP similar genes for KBTBD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KBTBD6: view

Variants for KBTBD6 Gene

Sequence variations from dbSNP and Humsavar for KBTBD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000478238 -- 41,132,525(+) TGGCG(A/G)CGGGC upstream-variant-2KB, utr-variant-5-prime
rs1001045150 -- 41,129,122(+) ACAAT(A/G)ACTAC utr-variant-3-prime
rs1001494249 -- 41,129,449(+) TGACA(C/T)AACTA utr-variant-3-prime
rs1001729070 -- 41,132,896(+) AAAGA(A/G)TCCGC upstream-variant-2KB
rs1002281097 -- 41,133,311(+) AAAAC(A/C)CCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KBTBD6 Gene

Variant ID Type Subtype PubMed ID
nsv974084 CNV duplication 23825009
nsv832587 CNV gain 17160897
esv2747299 CNV deletion 23290073

Variation tolerance for KBTBD6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD6 Gene

Disorders for KBTBD6 Gene

Relevant External Links for KBTBD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KBTBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD6 Gene

Publications for KBTBD6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60

Products for KBTBD6 Gene

Sources for KBTBD6 Gene

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