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KBTBD6 Gene

protein-coding GIFtS: 43

GC13M040599

kelch repeat and BTB (POZ) domain containing 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp547E1912 ^¹, ²
DKFZp547M073 ^²
FLJ58260 ^²
OTTHUMP00000018312 ^²

Descriptions
kelch repeat and BTB (POZ) domain containing 6 ^²
kelch repeat and BTB (POZ) domain-containing 6 ^²
kelch repeat and BTB domain containing 6 ^¹

External Ids
HGNC: 25340¹
Entrez Gene: 89890²
UniProtKB: Q86V97³
Ensembl: ENSG00000165572⁷

Search outside databases for aliases for KBTBD6 gene

Previous GC identifer: GC13M039501

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KBTBD6 gene

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3

KBTBD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M040599: (about GC identifiers)

Start:	40,599,705 bp from pter
End:	40,604,936 bp from pter
Size:	5,232 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KBTB6_HUMAN, Q86V97 (See protein sequence)

Recommended Name: Kelch repeat and BTB domain-containing protein 6

Size: 674 amino acids; 76138 Da

Secondary accessions: Q5T6Y8 Q8N8L0 Q8NDM5 Q96MP6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_690867.3

ENSEMBL proteins:

ENSP00000368799

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (KBTBD6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for KBTBD6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (KBTBD6)
	Novus Biologicals Antibody for KBTBD6

Assays for KBTBD6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q86V97

ProtoNet protein and cluster: Q86V97

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB011705 BTB/Kelch-associated

UniProtKB/Swiss-Prot: KBTB6_HUMAN, Q86V97

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 Kelch repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152903

Applied Biosystems Silencer® siRNAs for KBTBD6

Sigma-Aldrich siRNA and siRNA Panels for KBTBD6

Sigma-Aldrich shRNA for KBTBD6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KBTBD6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_152903
Myc/DDK tagged cDNA clone in CMV expression vector: NM_152903
untagged cDNA clone in CMV expression vector: NM_152903

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_152903

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KBTBD6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152903

Sigma-Aldrich siRNA and siRNA Panels for KBTBD6

Sigma-Aldrich shRNA for KBTBD6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_152903

REFSEQ mRNAs for KBTBD6 gene:

NM_152903.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_152903

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152903
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152903
                                 untagged cDNA clone in CMV expression vector: NM_152903

Additional cDNA sequence:

AK023475.1 AK056633.1 AK095195.1 AK299627.1 AL833839.1 BC000560.2 BC051349.1 CR749688.1

6 DOTS entries:

DT.40192958 DT.310302 DT.100776902 DT.92421318 DT.120794093 DT.99951720

24/105 AceView cDNA sequences (see all 105 ):

CD557535 AI146530 AK023475 CA433197 CA391237 AA481057 AW163314 BQ422957

BC000560 AI493011 BC051349 F12267 AW026560 AI693966 BI918149 AL833839

AI703243 AA665597 AU155969 BG714775 BG504358 BQ679169 BQ049892 CD655786

highest scoring ESTs for KBTBD6:

AA374087 AK056633 AK095195 AL521587 AL539909 AL549233 AL833839 AU252948 AW026560 AW840158

Unigene Cluster for KBTBD6:

Kelch repeat and BTB (POZ) domain containing 6

Hs.534040 [show with all ESTs]

Unigene Representative Sequence: NM_152903

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000379485

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KBTBD6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KBTBD6

¹ / ² / ³

4 probe-sets matching KBTBD6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89768_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AW026560	0.80	1.00	0.91	1
226479_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL359577	0.40	1.00	0.76	1
226479_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553111_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KBTBD6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.534040

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for KBTBD6 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KBTBD6¹	--	kelch repeat and BTB (POZ) domain containing 6	85.95(n) 91.1(a)	476934 XM_534135.2 XP_534135.2
chimpanzee (Pan troglodytes)	KBTBD6¹	--	kelch repeat and BTB (POZ) domain containing 6	99.7(n) 100(a)	452556 XM_509645.2 XP_509645.2
cow (Bos taurus)	KBTBD6¹	--	kelch repeat and BTB (POZ) domain containing 6	85.86(n) 89.32(a)	538461 XM_580490.3 XP_580490.3

About this table Species with no ortholog for KBTBD6

ENSEMBL Gene Tree for KBTBD6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KBTBD6 gene

KLHDC6² KBTBD7² KLHL11² KLHL38²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/37 NCBI SNPs in KBTBD6 are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 22)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1226^1,2	C,F,H,O	40599843(+)	`CTAAGC/TTTTAA`	1	--	ut3¹ ese³		9		MN NA EU EA WA	752
	rs1930510^1,2	A,C,F,H	40605710(-)	`CAAACC/TCTGAG`	1	--	ng3¹		9		EU EA WA NA MN	1804
	rs9566703^1,2	C,F,H	40604800(+)	`GCAGAG/ACCGCC`	1	--	ut5¹ ese³		4		EU EA WA	420
	rs560973^1,2	C,F,H	40606535(-)	`tgtctG/Ctataa`	1	--	ng3¹		8		MN EU EA WA NA	714
	rs9566704^1,2	F,H	40605272(+)	`GTGTGA/GAGATT`	1	--	ng3¹		4		EU EA WA	416
--	rs1952591^1,2	A	40601962(-)	`gctggG/Tcgtgg`	1	--	ut3¹		0	--	--	--	--
	rs584594^1,2	A,C,F,H	40603495(-)	`CCACTC/TTAGCT`	1	L/L	syn¹		14		EA NA EU WA	1042
--	rs74047631^1,2	--	40606518(+)	`GATAAA/GGGAAC`	1	--	ng3¹		0	--	--	--	--
--	rs71790947^1,2	--	40605660(+)	`TTTTT-/TTTTTT`	1	--	ng3¹		0	--	--	--	--
--	rs74047613^1,2	--	40600514(+)	`TTCAAC/GAGGTA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KBTBD6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for KBTBD6 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)⁴ Dunham A.... Ross M.T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 89890	HGNC: 25340	AceView: KBTBD6	Ensembl:ENSG00000165572	euGenes: HUgn89890
ECgene: KBTBD6	H-InvDB: KBTBD6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KBTBD6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KBTBD6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KBTBD6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KBTBD6		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KBTBD6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KBTBD6)
	Antibodies (KBTBD6)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for KBTBD6

Search Tocris compounds for KBTBD6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KBTBD6

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KBTBD6 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for KBTBD6

Summaries
for KBTBD6

Genomic Location
for KBTBD6

Proteins
for KBTBD6

Protein Domains/
Families
for KBTBD6

Gene Function
for KBTBD6

Pathways & Interactions
for KBTBD6

Drugs & Compounds
for KBTBD6

Transcripts
for KBTBD6

Expression
for KBTBD6

Orthologs
for KBTBD6

Paralogs
for KBTBD6

SNPs/Variants
for KBTBD6

Disorders & Mutations
for KBTBD6

Medical News
for KBTBD6

Publications
for KBTBD6

Search for KBTBD6

Genome Databases showing KBTBD6

Other Databases showing KBTBD6

Specialized Databases showing KBTBD6

Licensable Technologies
for KBTBD6

Services
for KBTBD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KBTBD6 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor KBTBD6

Summariesfor KBTBD6

Genomic Locationfor KBTBD6

Proteinsfor KBTBD6

Protein Domains/Familiesfor KBTBD6

Gene Functionfor KBTBD6

Pathways & Interactionsfor KBTBD6

Drugs & Compoundsfor KBTBD6

Transcriptsfor KBTBD6

Expression for KBTBD6

Orthologsfor KBTBD6

Paralogsfor KBTBD6

SNPs/Variantsfor KBTBD6

Disorders & Mutationsfor KBTBD6

Medical Newsfor KBTBD6

Publicationsfor KBTBD6

Search for KBTBD6

Genome Databases showing KBTBD6

Other Databases showing KBTBD6

Specialized Databases showing KBTBD6

Licensable Technologiesfor KBTBD6

Servicesfor KBTBD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KBTBD6

Summaries
for KBTBD6

Genomic Location
for KBTBD6

Proteins
for KBTBD6

Protein Domains/
Families
for KBTBD6

Gene Function
for KBTBD6

Pathways & Interactions
for KBTBD6

Drugs & Compounds
for KBTBD6

Transcripts
for KBTBD6

Expression
for KBTBD6

Orthologs
for KBTBD6

Paralogs
for KBTBD6

SNPs/Variants
for KBTBD6

Disorders & Mutations
for KBTBD6

Medical News
for KBTBD6

Publications
for KBTBD6

Licensable Technologies
for KBTBD6

Services
for KBTBD6