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Aliases for KBTBD4 Gene

Aliases for KBTBD4 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 4 2 3
  • BTB And Kelch Domain-Containing Protein 4 3 4
  • BTB And Kelch Domain Containing 4 2 3
  • BKLHD4 3 4
  • Kelch Repeat And BTB Domain-Containing Protein 4 3
  • HSPC252 3

External Ids for KBTBD4 Gene

Previous HGNC Symbols for KBTBD4 Gene

  • BKLHD4

Previous GeneCards Identifiers for KBTBD4 Gene

  • GC11M047558
  • GC11M047550
  • GC11M047597
  • GC11M047294
  • GC11M047707
  • GC11M048079
  • GC11M048802
  • GC11M049907

Summaries for KBTBD4 Gene

GeneCards Summary for KBTBD4 Gene

KBTBD4 (Kelch Repeat And BTB (POZ) Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is SPOPL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD4 Gene

Genomics for KBTBD4 Gene

Regulatory Elements for KBTBD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KBTBD4 Gene

47,572,197 bp from pter
47,579,015 bp from pter
6,819 bases
Minus strand

Genomic View for KBTBD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD4 Gene

Proteins for KBTBD4 Gene

  • Protein details for KBTBD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DQS1
    • D3DQS2
    • Q6IA85
    • Q9BUC3
    • Q9NV76

    Protein attributes for KBTBD4 Gene

    518 amino acids
    Molecular mass:
    58144 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KBTBD4 Gene

    Alternative splice isoforms for KBTBD4 Gene


neXtProt entry for KBTBD4 Gene

Proteomics data for KBTBD4 Gene at MOPED

Post-translational modifications for KBTBD4 Gene

  • Ubiquitination at Lys232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KBTBD4 Gene

Domains for KBTBD4 Gene

Gene Families for KBTBD4 Gene

  • BTBD :BTB/POZ domain containing

Protein Domains for KBTBD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NVX7
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KBTBD4: view

Function for KBTBD4 Gene

Gene Ontology (GO) - Molecular Function for KBTBD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD4: view

Phenotypes for KBTBD4 Gene

genes like me logo Genes that share phenotypes with KBTBD4: view

Animal Model Products

CRISPR Products

miRNA for KBTBD4 Gene

miRTarBase miRNAs that target KBTBD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KBTBD4 Gene

Localization for KBTBD4 Gene

Subcellular locations from

Jensen Localization Image for KBTBD4 Gene COMPARTMENTS Subcellular localization image for KBTBD4 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KBTBD4 Gene

Pathways for KBTBD4 Gene

SuperPathways for KBTBD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KBTBD4 Gene


No data available for Pathways by source for KBTBD4 Gene

Transcripts for KBTBD4 Gene

Unigene Clusters for KBTBD4 Gene

Kelch repeat and BTB (POZ) domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KBTBD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD4 Gene

No ASD Table

Relevant External Links for KBTBD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD4 Gene

mRNA expression in normal human tissues for KBTBD4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KBTBD4 Gene

SOURCE GeneReport for Unigene cluster for KBTBD4 Gene Hs.718483

genes like me logo Genes that share expressions with KBTBD4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KBTBD4 Gene

Orthologs for KBTBD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KBTBD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KBTBD4 35
  • 99.81 (n)
  • 99.63 (a)
  • 100 (a)
(Bos Taurus)
Mammalia KBTBD4 35
  • 93.07 (n)
  • 98.5 (a)
  • 98 (a)
(Canis familiaris)
Mammalia KBTBD4 35
  • 94.07 (n)
  • 98.88 (a)
  • 99 (a)
(Mus musculus)
Mammalia Kbtbd4 35
  • 91.76 (n)
  • 99.42 (a)
Kbtbd4 16
Kbtbd4 36
  • 99 (a)
(Monodelphis domestica)
Mammalia KBTBD4 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia KBTBD4 36
  • 91 (a)
(Gallus gallus)
Aves KBTBD4 35
  • 78.76 (n)
  • 90.35 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia KBTBD4 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd4 35
  • 73.62 (n)
  • 82.24 (a)
MGC76129 35
(Danio rerio)
Actinopterygii kbtbd4 35
  • 70.66 (n)
  • 76.45 (a)
kbtbd4 36
  • 76 (a)
zgc56204 35
fruit fly
(Drosophila melanogaster)
Insecta CG7058 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea bath-40 36
  • 11 (a)
bath-41 36
  • 9 (a)
bath-42 36
  • 14 (a)
Species with no ortholog for KBTBD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KBTBD4 Gene

Gene Tree for KBTBD4 (if available)
Gene Tree for KBTBD4 (if available)

Paralogs for KBTBD4 Gene

Paralogs for KBTBD4 Gene

genes like me logo Genes that share paralogs with KBTBD4: view

Variants for KBTBD4 Gene

Sequence variations from dbSNP and Humsavar for KBTBD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6485760 -- 47,576,049(+) ggtct(C/G)actgt intron-variant
rs7105784 -- 47,576,393(+) tgccc(A/G)cctcg intron-variant
rs7105845 -- 47,576,637(+) CCCAT(C/G)TGCCA intron-variant
rs9666433 -- 47,575,237(+) ggcgc(C/G)ggggc intron-variant
rs11039304 -- 47,576,187(+) tttga(A/G)atgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KBTBD4 Gene

Variant ID Type Subtype PubMed ID
nsv897325 CNV Loss 21882294
nsv832142 CNV Loss 17160897
nsv314 CNV Loss 18451855
nsv825872 CNV Gain 20364138
nsv509405 CNV Insertion 20534489

Relevant External Links for KBTBD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD4 Gene

Disorders for KBTBD4 Gene

No disorders were found for KBTBD4 Gene.

No data available for UniProtKB/Swiss-Prot for KBTBD4 Gene

Publications for KBTBD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for KBTBD4 Gene

  • antibodies-online proteins for KBTBD4
  • antibodies-online antibodies for KBTBD4
  • antibodies-online kits for KBTBD4

Sources for KBTBD4 Gene

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