KBTBD4 Gene
protein-coding GIFtS : 45
GCID: GC11 M048079
kelch repeat and BTB (POZ) domain containing 4 (Previous name: BTB and kelch domain containing 4 ) (Previous symbol: BKLHD4 )
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Aliasesfor KBTBD4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Kelch Repeat And BTB (POZ) Domain Containing 4 1 2 BTB And Kelch Domain-Containing Protein 42 3 BKLHD41 2 3 FLJ104501 HSPC2521 2 Kelch Repeat And BTB Domain-Containing Protein 42 BTB And Kelch Domain Containing 41 2
External Ids: HGNC: 23761 1 Entrez Gene: 55709 2 Ensembl: ENSG00000123444 7 UniProtKB: Q9NVX7 3 ORGUL members: NONCODE:n406706
Export aliases for KBTBD4 gene to outside databases Previous GC identifers: GC11M047558 GC11M047550 GC11M047597 GC11M047294 GC11M047707
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Summariesfor KBTBD4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor KBTBD4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KBTBD4 gene promoter: MEF-2A C/EBPbeta ATF-2 c-Jun aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for KBTBD4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KBTBD4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2 KBTBD4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M048079: view genomic region
(about GC identifiers )
Start:
47,593,749 bp from pter
End:
47,600,567 bp from pter
Size:
6,819 bases
Orientation:
minus strand
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Proteinsfor KBTBD4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KBTB4_HUMAN, Q9NVX7 (See
protein sequence )Recommended Name: Kelch repeat and BTB domain-containing protein 4 Size : 518 amino acids; 58144 Da
1 PDB 3D structure from and Proteopedia for KBTBD4 :2EQX (3D)
 
Secondary accessions : D3DQS1 D3DQS2 Q6IA85 Q9BUC3 Q9NV76Alternative splicing : 2 isoforms : Q9NVX7-1 Q9NVX7-2 Explore the universe of human proteins at neXtProt for KBTBD4: NX_Q9NVX7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NVX7 KBTBD4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_057590.3 NP_060565.4 ENSEMBL proteins: ENSP00000433340 ENSP00000436713 ENSP00000415106 ENSP00000434477 ENSP00000435850 ENSP00000433404 ENSP00000433653 ENSP00000435651 ENSP00000433124 ENSP00000378703 Human Recombinant Protein Products: KBTBD4 Antibody Products: Assay Products for KBTBD4:
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Protein
Domains / Familiesfor KBTBD4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KBTBD4 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NVX7 ProtoNet protein and cluster: Q9NVX7
3 Blocks protein families : IPB000210 BTB/POZ domain IPB011498 Kelch IPB011705 BTB/Kelch-associated UniProtKB/Swiss-Prot: KBTB4_HUMAN, Q9NVX7 Similarity : Contains 1 BACK (BTB/Kelch associated) domainSimilarity : Contains 1 BTB (POZ) domainSimilarity : Contains 5 Kelch repeats
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Functionfor KBTBD4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): KBTBD4 (NM_018095 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KBTBD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KBTBD4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD4
2 GenomeRNAi human phenotypes for KBTBD4 :
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Pathways & Interactionsfor KBTBD4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KBTBD4 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for KBTBD4 (Q9NVX7 3 ENSP00000415106 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor KBTBD4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KBTBD4 Search CenterWatch for drugs/clinical trials and news about KBTBD4 / KBTB4
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Transcriptsfor KBTBD4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KBTBD4 gene (2 alternative transcripts): NM_016506.5 NM_018095.4 Unigene Cluster for KBTBD4:
Kelch repeat and BTB (POZ) domain containing 4 Hs.718483 [show with all ESTs ] Unigene Representative Sequence: AK091607 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000526005 ENST00000533290 (uc001nfw.2 ) ENST00000430070 (uc001nfz.3 uc001nfy.3 )ENST00000525720 ENST00000530668 ENST00000529499 ENST00000531067 ENST00000529946 ENST00000534239 ENST00000395288 (uc001nfx.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): KBTBD4 (NM_018095 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KBTBD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KBTBD4
Additional cDNA sequence: AK001312.1 AK001749.1 AK091607.1 AK222550.1 AK222985.1 AK225062.1 AL713735.1 BC002736.2 CR457270.1 NR_024222.1
10 DOTS entries : DT.85104508 DT.92444702
DT.92444706 DT.100821907 DT.214236 DT.92444708 DT.120735733 DT.120735666 DT.75187930 DT.100719428 24/149 AceView cDNA sequences (see all 149 ):
BM783251 BX325285 BI767307 BI859927 BM758422 AL539902 BQ057933 BI836155 AL713735 BE895299 BU154139 AA360184 BQ221609 AL545694 BQ066797 CR616082 BM926918 BM758688 CF994882 BI598003 CR611741 BU192838 BU155772 BI831955 GeneLoc Exon Structure
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Expression for KBTBD4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KBTBD4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAGGTGTTCT
About this image KBTBD4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KBTBD4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KBTBD4 SOURCE GeneReport for Unigene cluster: Hs.718483 SABiosciences Custom PCR Arrays for KBTBD4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KBTBD4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KBTBD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KBTBD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KBTBD4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD4
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Orthologsfor KBTBD4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for KBTBD4 gene from 4/16 species (see all 16 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
KBTBD41
kelch repeat and BTB (POZ) domain containing 4
78.76(n) 90.35(a)
 
423180 NM_001199645.1 NP_001186574.1
lizard (Anolis carolinensis)
Reptilia
KBTBD46
--
86(a)
1 ↔ 1
1(44268880-44274784)
tropical clawed frog (Xenopus tropicalis)
Amphibia
MGC761292
hypothetical protein MGC76129
75.52(n)
 
BC064867.1
zebrafish (Danio rerio)
Actinopterygii
zgc562042
hypothetical protein MGC56204
73.42(n)
 
393178 BC045989.1
ENSEMBL Gene Tree for KBTBD4 (if available)TreeFam Gene Tree for KBTBD4 (if available)
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Paralogsfor KBTBD4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KBTBD4 gene GAN 2 11 SIMAP similar genes for KBTBD4 using alignment to 10 protein entries: KBTB4_HUMAN (see all proteins ):KLHL2 BTBD9 KLHL7 KLHL28 KBTBD3 KLHL24 KBTBD8 KLHL3 KEAP1 KLHL18 ZBTB38
KBTBD4 for paralogs About GeneDecksing
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Genomic Variantsfor KBTBD4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KBTBD4 (47593749 - 47600567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KBTBD4 1 CNV : 4741
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor KBTBD4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor KBTBD4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KBTBD4 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with KBTBD4) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 1 , 3 Zhang Q.-H.... Chen Z. (2000) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094) 1 Emanuele M.J....Elledge S.J. (2011) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 2 Taylor T.D....Sakaki Y. (2006)
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External Searches for KBTBD4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KBTBD4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KBTBD4 gene
(According to HUGE )
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Specialized Databases showing KBTBD4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KBTBD4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KBTBD4 gene: Search GeneIP for patents involving KBTBD4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KBTBD4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KBTBD4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KBTBD4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KBTBD4 OriGene Protein Over-expression Lysate for KBTBD4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KBTBD4 OriGene 3'-UTR Clone for KBTBD4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KBTBD4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KBTBD4 OriGene Custom Protein Services for KBTBD4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KBTBD4 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KBTBD4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KBTBD4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KBTBD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KBTBD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KBTBD4
Search Tocris compounds for KBTBD4
KBTBD4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD4
Search ThermoFisher Antibodies for KBTBD4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KBTBD4
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