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KBTBD3 Gene

protein-coding   GIFtS: 43

GC11M105427
kelch repeat and BTB (POZ) domain containing 3
(Previous name: BTB and kelch domain containing 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BKLHD3)
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Aliases &
Descriptions
for KBTBD3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BKLHD3 2, 3
FLJ30685 2
Descriptions
BTB and kelch domain containing 3 1, 2
BTB and kelch domain-containing protein 3 3
kelch repeat and BTB (POZ) domain containing 3 2
kelch repeat and BTB domain containing 3 1
External Ids
HGNC: 229341
Entrez Gene: 1438792
UniProtKB: Q8NAB23
Ensembl: ENSG000001823597
Search outside databases for aliases for KBTBD3 gene

Previous GC identifers: GC11M105460 GC11M105459

Summaries
for KBTBD3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for KBTBD3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KBTBD3 gene  

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

KBTBD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M105427:     (about GC identifiers)

Start:
 105,427,035 bp from pter
End:
 105,453,396 bp from pter
Size:
 26,362 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  

Proteins
for KBTBD3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: KBTB3_HUMAN, Q8NAB2 (See protein sequence)
Recommended Name: Kelch repeat and BTB domain-containing protein 3  
Size: 608 amino acids; 69395 Da
Secondary accessions: Q6N066 Q86X38 Q96NK5

REFSEQ proteins (2 alternative transcripts): 
NP_689646.2  NP_940841.1  


ENSEMBL proteins: 
ENSP00000384921 ENSP00000376829 ENSP00000328409 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for KBTBD3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KBTBD3

Assays for KBTBD3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for KBTBD3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/8 InterPro domains/families (see all 8 ):
 IPR017096 Kelch-like_gigaxonin
 IPR000210 BTB/POZ-like
 IPR006652 Kelch_1
 IPR011333 BTB/POZ_fold
 IPR013069 BTB_POZ


   GeneDecks  KBTBD3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8NAB2

ProtoNet protein and cluster: Q8NAB2

2 Blocks protein families:
IPB000210 BTB/POZ domain
IPB011705 BTB/Kelch-associated


UniProtKB/Swiss-Prot: KBTB3_HUMAN, Q8NAB2
Similarity: Contains 1 BACK (BTB/Kelch associated) domain
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 5 Kelch repeats

Gene Function
for KBTBD3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152433

              Applied Biosystems Silencer® siRNAs for KBTBD3

              Sigma-Aldrich siRNA and siRNA Panels for KBTBD3  
                     Sigma-Aldrich shRNA for KBTBD3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_152433
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_152433
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_152433 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_152433

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
About this table

Pathways & Interactions
for KBTBD3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for KBTBD3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KBTBD3

Transcripts
for KBTBD3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (KBTBD3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152433

              Sigma-Aldrich siRNA and siRNA Panels for KBTBD3  
                     Sigma-Aldrich shRNA for KBTBD3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

REFSEQ mRNAs for KBTBD3 gene (2 alternative transcripts): 

NM_152433.3   NM_198439.2   


               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_152433
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_152433
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_152433 

Additional cDNA sequence: 

AK055247.1 AK092993.1 AK124540.1 AK289915.1 BC047311.2 BC062667.1 BC107691.1 BC117466.1 
BX640672.1 BX647830.1 

7 DOTS entries:

DT.97836134  DT.210486  DT.443939  DT.101972846  DT.101980365  DT.120714442  DT.92418538 

24/60 AceView cDNA sequences (see all 60 ):

AI091794 AI140748 BM931798 AX747842 N63448 AI091086 AK092993 BG613139 
AI225119 CD108218 BM450437 AA398844 BX647830 AI948979 AK055247 BC047311 
AK124540 BI829778 AA435853 BX640672 BC062667 AI041728 AI284380 BI818757 

highest scoring ESTs for KBTBD3:

AI140748 AK092993 AK124540 BC062667 BF212002 BF697872 BM511139 BU561634 BU568372 BX640672 

Unigene Cluster for KBTBD3:

Kelch repeat and BTB (POZ) domain containing 3
Hs.101949  [show with all ESTs]
Unigene Representative Sequence: NM_198439


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD3

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1:                          -               
SP2:        -     -           -               
SP3:                                          

About this scheme

ECgene alternative splicing isoforms for KBTBD3

3 Ensembl transcripts including schematic representations:
ENST00000402992  ENST00000393121  ENST00000332166  

Expression
for KBTBD3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KBTBD3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KBTBD3

1 / 2 / 3

4 probe-sets matching KBTBD3 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
62137_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI140748 0.80 1.00 0.91 1

42264_r_at2, 3 U95-B 1 1.00 1.00 -0.17 0.31 D60267 0.80 1.00 0.91 1

228777_at2, 3 U133-B 1 1.00 1.00 -- -- AI436268 0.60 1.00 0.82 1

228777_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  KBTBD3 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AAACTACAAA

SOURCE GeneReport for Unigene cluster: Hs.101949

Orthologs
for KBTBD3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for KBTBD3 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 KBTBD31   -- kelch repeat and BTB (POZ) domain containing 3 90.03(n)
93.72(a)		 479456  XM_536591.2  XP_536591.2 
chimpanzee
(Pan troglodytes)		 KBTBD31   -- kelch repeat and BTB (POZ) domain containing 3 99.78(n)
100(a)		 451523  XM_508733.2  XP_508733.2 
cow
(Bos taurus)		 KBTBD31   -- kelch repeat and BTB (POZ) domain containing 3 93.87(n)
94.91(a)		 524207  XM_602528.3  XP_602528.3 
rat
(Rattus norvegicus)		 Kbtbd31   -- kelch repeat and BTB (POZ) domain containing 3 88.15(n)
90.91(a)		 315394  XM_235782.4  XP_235782.2 
mouse
(Mus musculus)		 Kbtbd31, 5 95
 kelch repeat and BTB (POZ) domain containing 31, 5 87.93(n)1
91.24(a)1		 691491  NM_026962.21  NP_081238.11 
 AI3260025  AK0086275  (see all 14)
About this table        Species with no ortholog for KBTBD3

ENSEMBL Gene Tree for KBTBD3

Paralogs
for KBTBD3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KBTBD3 gene
KBTBD102  KBTBD52  KBTBD82  CCIN2  

SNPs/Variants
for KBTBD3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/136 NCBI SNPs in KBTBD3 are shown (see all 136 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 83)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs19407921,2
A,C,F,H,O105427801(-) GATGTT/ATACCA 2 -- ut31 ese37Minor allele frequency- A:0.07NA EU EA WA 556
rs19407911,2
A,C,F,H,O105427929(-) TTAAGA/GACATA 2 -- ut317Minor allele frequency- G:0.07NA EU EA WA 562
rs19398011,2
A,C,F,H105428583(-) TTAACC/TTTGGG 2 -- ut3111Minor allele frequency- T:0.36NA EA EU WA 2302
rs37373471,2
C,F,H105428774(-) AAAACG/AAGTCC 2 -- ut31 ese38Minor allele frequency- A:0.32EA EU WA NA 2032
rs65911491,2
C,F,H105427409(+) TAGGTA/GTATTT 2 -- ut31 ese37Minor allele frequency- G:0.06NA EU EA WA 534
rs170938111,2
C,F,H105427145(+) TTCTCA/CAATAA 2 -- ut3111Minor allele frequency- C:0.11NA EU EA WA 982
rs357628211,2
C,F105430049(+) ATTCAT/CCTCTA 2 V/M mis15Minor allele frequency- C:0.01NA EU EA WA 496
rs74803621,2
C,H105426543(+) TTTCCA/CATAAG 2 -- ng514Minor allele frequency- C:0.00EU EA WA 420
rs45392971,2
C,H105426591(+) GAGGCA/CAAATA 2 -- ng514Minor allele frequency- C:0.00EU EA WA 420
rs124191161,2
H105426873(+) GCCACC/TTAGGC 2 -- ng514Minor allele frequency- T:0.00EU EA WA 416
About this table

HapMap Linkage Disequilibrium images for KBTBD3 (up to first 250kb)

Disorders & Mutations
for KBTBD3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for KBTBD3

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for KBTBD3

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for KBTBD3 gene:

Search for KBTBD3

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing KBTBD3

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 143879 HGNC: 22934 AceView: KBTBD3 Ensembl:ENSG00000182359 euGenes: HUgn143879
ECgene: KBTBD3 H-InvDB: KBTBD3

Other Databases showing KBTBD3

(According to HUGE)
About This Section

   --

Specialized Databases showing KBTBD3

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for KBTBD3

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for KBTBD3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KBTBD3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for KBTBD3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for KBTBD3 Browse antibodies at Sigma-Aldrich
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 Lentivirus-delivered shRNAs for KBTBD3 Browse small molecules at Sigma-Aldrich
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