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Aliases for KBTBD3 Gene

Aliases for KBTBD3 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 3 2 3
  • BTB And Kelch Domain-Containing Protein 3 3 4
  • BTB And Kelch Domain Containing 3 2 3
  • BKLHD3 3 4

External Ids for KBTBD3 Gene

Previous HGNC Symbols for KBTBD3 Gene

  • BKLHD3

Previous GeneCards Identifiers for KBTBD3 Gene

  • GC11M105460
  • GC11M105459
  • GC11M105427
  • GC11M105921
  • GC11M101852

Summaries for KBTBD3 Gene

GeneCards Summary for KBTBD3 Gene

KBTBD3 (Kelch Repeat And BTB (POZ) Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD3 Gene

Genomics for KBTBD3 Gene

Regulatory Elements for KBTBD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KBTBD3 Gene

Chromosome:
11
Start:
106,046,806 bp from pter
End:
106,077,765 bp from pter
Size:
30,960 bases
Orientation:
Minus strand

Genomic View for KBTBD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD3 Gene

Proteins for KBTBD3 Gene

  • Protein details for KBTBD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAB2-KBTB3_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 3
    Protein Accession:
    Q8NAB2
    Secondary Accessions:
    • Q6N066
    • Q86X38
    • Q96NK5

    Protein attributes for KBTBD3 Gene

    Size:
    608 amino acids
    Molecular mass:
    69395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17467.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45804.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW67073.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KBTBD3 Gene

Proteomics data for KBTBD3 Gene at MOPED

Post-translational modifications for KBTBD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD3 Gene

No data available for DME Specific Peptides for KBTBD3 Gene

Domains & Families for KBTBD3 Gene

Gene Families for KBTBD3 Gene

Suggested Antigen Peptide Sequences for KBTBD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NAB2

UniProtKB/Swiss-Prot:

KBTB3_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 5 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KBTBD3: view

Function for KBTBD3 Gene

Gene Ontology (GO) - Molecular Function for KBTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD3: view

Phenotypes for KBTBD3 Gene

genes like me logo Genes that share phenotypes with KBTBD3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD3 Gene

Localization for KBTBD3 Gene

Gene Ontology (GO) - Cellular Components for KBTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KBTBD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KBTBD3 Gene

Pathways & Interactions for KBTBD3 Gene

SuperPathways for KBTBD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KBTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with KBTBD3: view

No data available for Pathways by source and SIGNOR curated interactions for KBTBD3 Gene

Drugs & Compounds for KBTBD3 Gene

No Compound Related Data Available

Transcripts for KBTBD3 Gene

Unigene Clusters for KBTBD3 Gene

Kelch repeat and BTB (POZ) domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - - -
SP3:

Relevant External Links for KBTBD3 Gene

GeneLoc Exon Structure for
KBTBD3
ECgene alternative splicing isoforms for
KBTBD3

Expression for KBTBD3 Gene

mRNA expression in normal human tissues for KBTBD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KBTBD3 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KBTBD3 Gene



SOURCE GeneReport for Unigene cluster for KBTBD3 Gene Hs.101949

genes like me logo Genes that share expression patterns with KBTBD3: view

Protein tissue co-expression partners for KBTBD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KBTBD3 Gene

Orthologs for KBTBD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KBTBD3 35
  • 93.94 (n)
  • 95.21 (a)
KBTBD3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KBTBD3 35
  • 90.03 (n)
  • 93.72 (a)
KBTBD3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kbtbd3 35
  • 87.93 (n)
  • 91.4 (a)
Kbtbd3 16
Kbtbd3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KBTBD3 35
  • 99.78 (n)
  • 100 (a)
KBTBD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kbtbd3 35
  • 88.15 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia KBTBD3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KBTBD3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves KBTBD3 35
  • 78.64 (n)
  • 82.12 (a)
KBTBD3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KBTBD3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd3 35
  • 72.85 (n)
  • 77.23 (a)
zebrafish
(Danio rerio)
Actinopterygii kbtbd3 35
  • 57.12 (n)
  • 57.29 (a)
kbtbd3 36
  • 56 (a)
OneToOne
Species with no ortholog for KBTBD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD3 Gene

ENSEMBL:
Gene Tree for KBTBD3 (if available)
TreeFam:
Gene Tree for KBTBD3 (if available)

Paralogs for KBTBD3 Gene

genes like me logo Genes that share paralogs with KBTBD3: view

Variants for KBTBD3 Gene

Sequence variations from dbSNP and Humsavar for KBTBD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1893174 -- 106,059,457(-) AAACT(A/G)TGTTA intron-variant
rs1939784 -- 106,050,252(-) ACGCT(C/T)ATTAT utr-variant-3-prime
rs1939785 -- 106,047,466(-) TAATT(A/T)TTTGT utr-variant-3-prime
rs1939786 -- 106,047,344(-) AGAGC(A/G)AAATT utr-variant-3-prime
rs1939787 -- 106,046,960(-) AGAAC(G/T)AAAAT utr-variant-3-prime

Variation tolerance for KBTBD3 Gene

Residual Variation Intolerance Score: 15.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD3 Gene

HapMap Linkage Disequilibrium report
KBTBD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KBTBD3 Gene

Disorders for KBTBD3 Gene

Relevant External Links for KBTBD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KBTBD3
genes like me logo Genes that share disorders with KBTBD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD3 Gene

Publications for KBTBD3 Gene

  1. Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays. (PMID: 20353815) Yilmaz S. … McGregor J.L. (Genomics 2010) 67
  2. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PMID: 17342744) Dall'Era M.A. … Liu A.Y. (Prostate 2007) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for KBTBD3 Gene

Sources for KBTBD3 Gene

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