Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KBTBD2 Gene

protein-coding   GIFtS: 48
GCID: GC07M032909

Kelch Repeat And BTB (POZ) Domain Containing 2

(Previous name: BTB and kelch domain containing 1)
(Previous symbol: BKLHD1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch Repeat And BTB (POZ) Domain Containing 21 2
BKLHD11 2 3
BTB And Kelch Domain Containing 11 2
BTB And Kelch Domain-Containing Protein 12 3
Kelch Repeat And BTB Domain-Containing Protein 22
KIAA14893

External Ids:    HGNC: 217511   Entrez Gene: 259482   Ensembl: ENSG000001708527   UniProtKB: Q8IY473   

Export aliases for KBTBD2 gene to outside databases

Previous GC identifers: GC07M032650 GC07M032681 GC07M032874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KBTBD2 Gene:
KBTBD2 (kelch repeat and BTB (POZ) domain containing 2) is a protein-coding gene. An important paralog of this gene is KLHL21.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KBTBD2 gene promoter:
         STAT5B   STAT1   STAT4   STAT2   STAT3   STAT1beta   STAT6   STAT5A   Ik-3   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): KBTBD2 promoter sequence
   Search Chromatin IP Primers for KBTBD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KBTBD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

KBTBD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KBTBD2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M032909:  view genomic region     (about GC identifiers)

Start:
32,907,778 bp from pter      End:
32,933,743 bp from pter
Size:
25,966 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 32,952,292-32,975,978     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KBTB2_HUMAN, Q8IY47 (See protein sequence)
Recommended Name: Kelch repeat and BTB domain-containing protein 2  
Size: 623 amino acids; 71331 Da
Sequence caution: Sequence=AAD34068.1; Type=Frameshift; Positions=328;
Secondary accessions: A8K9T7 Q86Y62 Q9P239 Q9UFM7 Q9Y382

Explore the universe of human proteins at neXtProt for KBTBD2: NX_Q8IY47

Explore proteomics data for KBTBD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KBTBD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056298.2  
    ENSEMBL proteins: 
     ENSP00000302586   ENSP00000395715   ENSP00000407059   ENSP00000407520   ENSP00000388236  

    KBTBD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KBTBD2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KBTBD2
    GenScript Custom Purified and Recombinant Proteins Services for KBTBD2
    Novus Biologicals KBTBD2 Protein
    Novus Biologicals KBTBD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KBTBD2

     
    Search eBioscience for Proteins for KBTBD2 

    KBTBD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KBTBD2
    Novus Biologicals KBTBD2 Antibody
    Abcam antibodies for KBTBD2
    Cloud-Clone Corp. Antibodies for KBTBD2
    Search ThermoFisher Antibodies for KBTBD2
    LSBio Antibodies in human, mouse, rat for KBTBD2

    KBTBD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KBTBD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KBTBD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KBTBD2
    Cloud-Clone Corp. CLIAs for KBTBD2
    Search eBioscience for ELISAs for KBTBD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    Selected InterPro protein domains (see all 7):
     IPR017096 Kelch-like_gigaxonin-typ
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q8IY47

    ProtoNet protein and cluster: Q8IY47

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KBTB2_HUMAN, Q8IY47
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    Find genes that share domains with KBTBD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KBTBD2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KBTBD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KBTBD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KBTBD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KBTBD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KBTBD2:
    hsa-mir-130b-3p (MIRT020285), hsa-mir-151a-3p (MIRT019503), hsa-mir-155-5p (MIRT005097)

    Block miRNA regulation of human, mouse, rat KBTBD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KBTBD2 (see all 30):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-4291 hsa-miR-3146 hsa-miR-449c* hsa-miR-15a hsa-miR-218-1* hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidKBTBD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KBTBD2
    Predesigned siRNA for gene silencing in human, mouse, rat KBTBD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KBTBD2

    Clone
    Products:
         
    OriGene clones in human, mouse for KBTBD2 (see all 7)
    OriGene ORF clones in mouse, rat for KBTBD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KBTBD2 (NM_015483)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KBTBD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KBTBD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KBTBD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KBTBD2
    Interactions:

        Search GeneGlobe Interaction Network for KBTBD2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KBTBD2 (Q8IY473 ENSP000003025864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBXN7O948883, ENSP000002963284I2D: score=1 STRING: ENSP00000296328
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KBTBD2 (KBTB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KBTBD2 gene: 
    NM_015483.2  

    Unigene Cluster for KBTBD2:

    Kelch repeat and BTB (POZ) domain containing 2
    Hs.372541  [show with all ESTs]
    Unigene Representative Sequence: AB040922
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304056(uc003tdb.2) ENST00000485611 ENST00000477129 ENST00000452926
    ENST00000453627 ENST00000423022 ENST00000424468
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KBTBD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KBTBD2 (see all 30):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-4291 hsa-miR-3146 hsa-miR-449c* hsa-miR-15a hsa-miR-218-1* hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidKBTBD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KBTBD2
    Predesigned siRNA for gene silencing in human, mouse, rat KBTBD2
    Clone
    Products:
         
    OriGene clones in human, mouse for KBTBD2 (see all 7)
    OriGene ORF clones in mouse, rat for KBTBD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KBTBD2 (NM_015483)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KBTBD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KBTBD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KBTBD2
      QuantiTect SYBR Green Assays in human, mouse, rat KBTBD2
      QuantiFast Probe-based Assays in human, mouse, rat KBTBD2

    Additional mRNA sequence: 

    AB040922.1 AF004292.1 AF151831.1 AF161402.1 AK024557.1 AK292802.1 AL117562.1 BC014633.2 
    BC032367.1 BC037887.2 BC047107.1 

    8 DOTS entries:

    DT.95254707  DT.95250793  DT.100651115  DT.455927  DT.92408958  DT.121048751  DT.100697036  DT.40228743 

    Selected AceView cDNA sequences (see all 279):

    BE464083 BM697561 BF590286 BM955897 BM955898 AI082212 BM795991 AI186623 
    AI129345 CR595245 BM989731 AA643230 AI078568 BM472868 BC014633 AI022320 
    BQ018887 BM477757 AA159567 AI124857 AI420197 BX280502 BX111844 AI424526 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
    SP1:        -     -     -                 -     -     -                           
    SP2:                                                                              
    SP3:                    -                 -     -     -                           
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for KBTBD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KBTBD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGGCACT
    KBTBD2 Expression
    About this image

    KBTBD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KBTBD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372541
        Custom PCR Arrays for KBTBD2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KBTBD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KBTBD2
    QuantiTect SYBR Green Assays in human, mouse, rat KBTBD2
    QuantiFast Probe-based Assays in human, mouse, rat KBTBD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KBTBD2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kbtbd21 , 5 kelch repeat and BTB (POZ) domain containing 21, 5 91.81(n)1
    98.56(a)1
      6 (27.73 cM)5
    2109731  NM_145958.21  NP_666070.21 
     567775245 
    chicken
    (Gallus gallus)
    Aves KBTBD21 kelch repeat and BTB (POZ) domain containing 2 84.8(n)
    94.38(a)
      420749  XM_418847.4  XP_418847.2 
    lizard
    (Anolis carolinensis)
    Reptilia KBTBD26
    kelch repeat and BTB (POZ) domain containing 2
    92(a)
    1 ↔ 1
    6(45275152-45280296)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA789452.12   -- 78.97(n)    CA789452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM861068.12   -- 78.47(n)    BM861068.1 


    ENSEMBL Gene Tree for KBTBD2 (if available)
    TreeFam Gene Tree for KBTBD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KBTBD2 gene
    KLHL212  KLHL62  KBTBD82  KLHL412  KBTBD122  KLHL242  ENC12  KLHL382  
    KLHL292  KBTBD32  KLHL232  KLHL402  KBTBD72  KLHL352  KLHL302  KBTBD62  
    KLHL252  
    3 SIMAP similar genes for KBTBD2 using alignment to 4 protein entries:     KBTB2_HUMAN (see all proteins):
    KLHL24    KBTBD3    KBTBD8

    Find genes that share paralogs with KBTBD2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KBTBD2
    PGOHUM00000237068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KBTBD2 (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880610821,2
    --32812318(+) TCTCGA/GCATTG 1 -- int10--------
    rs1895936121,2
    --32907340(+) TGAATA/GGCATA 1 -- ds50010--------
    rs64624271,2
    C,F,A,H--32907344(+) TAGCAT/CAAAAA 1 -- ds500124Minor allele frequency- C:0.25EA NA NS 2858
    rs1833741031,2
    --32907355(+) AGCATA/GAAGCA 1 -- ds50010--------
    rs1482590201,2
    --32907364(+) CATAGC/TGAAAG 1 -- ds50010--------
    rs1413373581,2
    --32907411(+) AAGGTA/CGGGCT 1 -- ds50010--------
    rs1165221751,2
    C,F--32907440(+) CAAATT/GAGAGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1861885841,2
    --32907449(+) GAGAGA/CCTTAA 1 -- ds50010--------
    rs787278411,2
    C--32907635(+) GGTAGA/GAAGAC 1 -- ds50010--------
    rs1906531841,2
    --32907666(+) TGCATA/CTCTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KBTBD2 (32907778 - 32933743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KBTBD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1127e201CNV Deletion23290073
    nsv436907CNV Insertion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KBTBD2
    DNA2.0 Custom Variant and Variant Library Synthesis for KBTBD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KBTBD2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with KBTBD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 25948 HGNC: 21751 AceView: KBTBD2 Ensembl:ENSG00000170852 euGenes: HUgn25948
    ECgene: KBTBD2 H-InvDB: KBTBD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1489

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KBTBD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KBTBD2 gene:
    Search GeneIP for patents involving KBTBD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KBTBD2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KBTBD2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KBTBD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KBTBD2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KBTBD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KBTBD2   OriGene Custom Protein Services for KBTBD2  

     
     
     Block miRNA regulation of human, mouse, rat KBTBD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KBTBD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KBTBD2 Predesigned siRNA for gene silencing in human, mouse, rat KBTBD2
     QuantiFast Probe-based Assays in human, mouse, rat KBTBD2 QuantiTect SYBR Green Assays in human, mouse, rat KBTBD2
     Custom PCR Arrays for KBTBD2 Search Chromatin IP Primers for KBTBD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KBTBD2  Search GeneGlobe Interaction Network for KBTBD2
     Regulatory tfbs in KBTBD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KBTBD2 GenScript cDNA clones with any tag delivered in your preferred vector for KBTBD2
     GenScript Custom Assay Services for KBTBD2 GenScript Custom overexpressing Cell Line Services for KBTBD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KBTBD2 (KBTB2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KBTBD2 antibodies
     KBTBD2 proteins
     KBTBD2 lysates
     Antibodies for KBTBD2
     See all of Abcam's Antibodies, Kits and Proteins for KBTBD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KBTBD2
     Antibodies for KBTBD2
     ELISAs for KBTBD2
     CLIAs for KBTBD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for KBTBD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2
     SwitchGear 3'UTR luciferase reporter plasmids for KBTBD2
     SwitchGear Promoter luciferase reporter plasmids for KBTBD2
     Search ThermoFisher Antibodies for KBTBD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KBTBD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KBTBD2
     LSBio Antibodies in human, mouse, rat for KBTBD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KBTBD2
      Search eBioscience for proteins for KBTBD2
      Search eBioscience for elisas for KBTBD2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KBTBD2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4