KBTBD2 Gene
protein-coding GIFtS: 45
GCID: GC07M032874
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|
kelch repeat and BTB (POZ) domain containing 2(Previous name: BTB and kelch domain containing 1 )
(Previous symbol: BKLHD1)
| |
Aliases
for KBTBD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch Repeat And BTB (POZ) Domain Containing 21 2 | | DKFZP566C1341 | | BKLHD11 2 3 | | Kelch Repeat And BTB Domain-Containing Protein 22 | | BTB And Kelch Domain Containing 11 2 | | KIAA14893 | | BTB And Kelch Domain-Containing Protein 12 3 | | |
Export aliases for KBTBD2 gene to outside databasesPrevious GC identifers: GC07M032650 GC07M032681 |
Summaries
for KBTBD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KBTBD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KBTBD2 gene promoter:
STAT5B STAT1 STAT4 STAT2 STAT3 STAT1beta STAT6 STAT5A Ik-3 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KBTBD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KBTBD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p14.3 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p14.3KBTBD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M032874: view genomic region
(about GC identifiers)
Start:
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32,907,778 bp from pter |
End:
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32,933,743 bp from pter |
Size:
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25,966 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 32,952,292-32,975,978 |
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Proteins
for KBTBD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KBTB2_HUMAN, Q8IY47 (See
protein sequence)Recommended Name: Kelch repeat and BTB domain-containing protein 2 Size: 623 amino acids; 71331 Da
Sequence caution: Sequence=AAD34068.1; Type=Frameshift; Positions=328;
Secondary accessions: A8K9T7 Q86Y62 Q9P239 Q9UFM7 Q9Y382Explore the universe of human proteins at neXtProt for KBTBD2: NX_Q8IY47
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IY47
KBTBD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056298.2
ENSEMBL proteins: ENSP00000302586 ENSP00000395715 ENSP00000407059 ENSP00000407520 ENSP00000388236
Human Recombinant Protein Products:
KBTBD2 Antibody Products:
Assay Products for KBTBD2: |
Protein
Domains /
Families
for KBTBD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KBTBD2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8IY47ProtoNet protein and cluster: Q8IY47 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KBTB2_HUMAN, Q8IY47Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 Kelch repeats |
Function
for KBTBD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KBTBD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2 |
|
Pathways & Interactions
for KBTBD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KBTBD2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KBTBD2 (Q8IY473 ENSP000003025864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KBTBD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KBTBD2
Search CenterWatch for drugs/clinical trials and news about KBTBD2 / KBTB2
|
Transcripts
for KBTBD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KBTBD2 gene: NM_015483.2 Unigene Cluster for KBTBD2: Kelch repeat and BTB (POZ) domain containing 2 Hs.372541 [show with all ESTs]Unigene Representative Sequence: AB0409227 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304056(uc003tdb.2) ENST00000485611 ENST00000477129 ENST00000452926
ENST00000453627 ENST00000423022 ENST00000424468
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KBTBD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KBTBD2 (NM_015483) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KBTBD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2 |
Additional cDNA sequence: AB040922.1 AF004292.1 AF151831.1 AF161402.1 AK024557.1 AK292802.1 AL117562.1 BC014633.2 BC032367.1 BC037887.2 BC047107.1 8 DOTS entries: DT.95254707 DT.95250793 DT.100651115 DT.455927 DT.92408958 DT.121048751 DT.100697036 DT.40228743 24/279 AceView cDNA sequences (see all 279): BQ005159 BE464083 AI886138 BM795991 AI424526 CR595245 AL600054 BM477757 BU154085 BX507403 AI142924 BQ881191 AI078568 BE093069 BM472868 AI129345 BQ018887 AA643230 BM989731 BM449853 BQ421609 BC014633 AI186623 AA307232
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
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| SP1: | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KBTBD2
|
Expression
for KBTBD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KBTBD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGGCACT
About this image
See KBTBD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KBTBD2
SOURCE GeneReport for Unigene cluster: Hs.372541
SABiosciences Custom PCR Arrays for KBTBD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KBTBD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KBTBD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KBTBD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KBTBD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2 |
Orthologs
for KBTBD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KBTBD2 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for KBTBD2 (if available)
TreeFam Gene Tree for KBTBD2 (if available) |
Paralogs
for KBTBD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KBTBD2 gene
- KBTBD122 KLHL402 KBTBD72 KLHL72 KBTBD82 KLHL412 KBTBD62
3 SIMAP similar genes for KBTBD2 using alignment to 4 protein entries: KBTB2_HUMAN (see all proteins):KLHL24 KBTBD3 KBTBD8
KBTBD2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KBTBD2
PGOHUM00000237068
|
Genomic Variants
for KBTBD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KBTBD2 (32907778 - 32933743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KBTBD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KBTBD2 |
|
Disorders
/ Diseases
for KBTBD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KBTBD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KBTBD2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KBTBD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)1 Alexandru G....Deshaies R.J. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for KBTBD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KBTBD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KBTBD2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KBTBD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KBTBD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KBTBD2 gene:
Search GeneIP for patents involving KBTBD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KBTBD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KBTBD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KBTBD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KBTBD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KBTBD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KBTBD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KBTBD2 |
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 | | | KBTBD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KBTBD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for KBTBD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KBTBD2 |
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