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Aliases for KBTBD12 Gene

Aliases for KBTBD12 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 12 2 3
  • Kelch Domain-Containing Protein 6 3 4
  • Kelch Domain Containing 6 2 3
  • KLHDC6 3 4
  • Kelch Repeat And BTB Domain-Containing Protein 12 3

External Ids for KBTBD12 Gene

Previous Symbols for KBTBD12 Gene

  • KLHDC6

Summaries for KBTBD12 Gene

GeneCards Summary for KBTBD12 Gene

KBTBD12 (Kelch Repeat And BTB (POZ) Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD12 Gene

Genomics for KBTBD12 Gene

Genomic Location for KBTBD12 Gene

Start:
127,915,232 bp from pter
End:
127,987,671 bp from pter
Size:
72,440 bases
Orientation:
Plus strand

Genomic View for KBTBD12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD12 Gene

No data available for Regulatory Elements for KBTBD12 Gene

Proteins for KBTBD12 Gene

  • Protein details for KBTBD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCT8-KBTBC_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 12
    Protein Accession:
    Q3ZCT8
    Secondary Accessions:
    • B5MCC6
    • Q6ZRK1

    Protein attributes for KBTBD12 Gene

    Size:
    623 amino acids
    Molecular mass:
    71096 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KBTBD12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KBTBD12 Gene

Proteomics data for KBTBD12 Gene at MOPED

Post-translational modifications for KBTBD12 Gene

No Post-translational modifications

Other Protein References for KBTBD12 Gene

No data available for DME Specific Peptides for KBTBD12 Gene

Domains for KBTBD12 Gene

Gene Families for KBTBD12 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for KBTBD12 Gene

UniProtKB/Swiss-Prot:

KBTBC_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q3ZCT8
  • Contains 1 BTB (POZ) domain.:
    • Q3ZCT8
Similarity:
  • Contains 4 Kelch repeats.:
    • Q3ZCT8
genes like me logo Genes that share domains with KBTBD12: view

Function for KBTBD12 Gene

Gene Ontology (GO) - Molecular Function for KBTBD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD12: view

Phenotypes for KBTBD12 Gene

GenomeRNAi human phenotypes for KBTBD12:
genes like me logo Genes that share phenotypes with KBTBD12: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KBTBD12 Gene

Localization for KBTBD12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KBTBD12 Gene COMPARTMENTS Subcellular localization image for KBTBD12 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for KBTBD12 Gene

Pathways for KBTBD12 Gene

SuperPathways for KBTBD12 Gene

No Data Available

Interacting Proteins for KBTBD12 Gene

Gene Ontology (GO) - Biological Process for KBTBD12 Gene

None

No data available for Pathways by source for KBTBD12 Gene

Transcripts for KBTBD12 Gene

mRNA/cDNA for KBTBD12 Gene

Unigene Clusters for KBTBD12 Gene

Kelch repeat and BTB (POZ) domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD12 Gene

No ASD Table

Relevant External Links for KBTBD12 Gene

GeneLoc Exon Structure for
KBTBD12
ECgene alternative splicing isoforms for
KBTBD12

Expression for KBTBD12 Gene

mRNA expression in normal human tissues for KBTBD12 Gene

mRNA differential expression in normal tissues according to GTEx for KBTBD12 Gene

This gene is overexpressed in Muscle - Skeletal (12.7) and Heart - Left Ventricle (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KBTBD12 Gene

SOURCE GeneReport for Unigene cluster for KBTBD12 Gene Hs.132087

genes like me logo Genes that share expressions with KBTBD12: view

Orthologs for KBTBD12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KBTBD12 36
  • 99.73 (n)
  • 99.36 (a)
KBTBD12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KBTBD12 36
  • 81.43 (n)
  • 88.57 (a)
KBTBD12 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KBTBD12 36
  • 91.87 (n)
  • 94.06 (a)
KBTBD12 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kbtbd12 36
  • 87.22 (n)
  • 92.11 (a)
Kbtbd12 16
Kbtbd12 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KBTBD12 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kbtbd12 36
  • 86.55 (n)
  • 90.84 (a)
chicken
(Gallus gallus)
Aves KBTBD12 36
  • 75.28 (n)
  • 75.44 (a)
KBTBD12 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KBTBD12 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd12 36
  • 68.36 (n)
  • 68.41 (a)
zebrafish
(Danio rerio)
Actinopterygii kbtbd12 36
  • 60 (n)
  • 57.38 (a)
kbtbd12 37
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for KBTBD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD12 Gene

ENSEMBL:
Gene Tree for KBTBD12 (if available)
TreeFam:
Gene Tree for KBTBD12 (if available)

Paralogs for KBTBD12 Gene

Selected SIMAP similar genes for KBTBD12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KBTBD12: view

Variants for KBTBD12 Gene

Sequence variations from dbSNP and Humsavar for KBTBD12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1469655 -- 127,959,988(-) CTGTC(A/G)TGCTA intron-variant
rs1469656 -- 127,959,961(-) AAAAT(A/G)TACAT intron-variant
rs1864889 -- 127,972,439(-) AAAAC(A/C)CAACA intron-variant
rs2053015 -- 127,939,243(-) CACAC(C/T)CTCTT intron-variant
rs2053016 -- 127,926,345(-) AATAT(A/G)TAAAT intron-variant

Relevant External Links for KBTBD12 Gene

HapMap Linkage Disequilibrium report
KBTBD12

No data available for Structural Variations from Database of Genomic Variants (DGV) for KBTBD12 Gene

Disorders for KBTBD12 Gene

Relevant External Links for KBTBD12

Genetic Association Database (GAD)
KBTBD12
Human Genome Epidemiology (HuGE) Navigator
KBTBD12
genes like me logo Genes that share disorders with KBTBD12: view

No data available for UniProtKB/Swiss-Prot for KBTBD12 Gene

Publications for KBTBD12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for KBTBD12 Gene

Sources for KBTBD12 Gene

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