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Aliases for KBTBD12 Gene

Aliases for KBTBD12 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 12 2 3
  • Kelch Domain-Containing Protein 6 3 4
  • Kelch Domain Containing 6 2 3
  • KLHDC6 3 4
  • Kelch Repeat And BTB Domain-Containing Protein 12 3

External Ids for KBTBD12 Gene

Previous HGNC Symbols for KBTBD12 Gene

  • KLHDC6

Previous GeneCards Identifiers for KBTBD12 Gene

  • GC03P129124
  • GC03P127635
  • GC03P125022

Summaries for KBTBD12 Gene

GeneCards Summary for KBTBD12 Gene

KBTBD12 (Kelch Repeat And BTB (POZ) Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD12 Gene

Genomics for KBTBD12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KBTBD12 Gene

127,915,232 bp from pter
127,987,671 bp from pter
72,440 bases
Plus strand

Genomic View for KBTBD12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD12 Gene

No data available for Regulatory Elements for KBTBD12 Gene

Proteins for KBTBD12 Gene

  • Protein details for KBTBD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • B5MCC6
    • Q6ZRK1

    Protein attributes for KBTBD12 Gene

    623 amino acids
    Molecular mass:
    71096 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KBTBD12 Gene


neXtProt entry for KBTBD12 Gene

Proteomics data for KBTBD12 Gene at MOPED

Post-translational modifications for KBTBD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD12 Gene

No data available for DME Specific Peptides for KBTBD12 Gene

Domains for KBTBD12 Gene

Gene Families for KBTBD12 Gene

Protein Domains for KBTBD12 Gene

Suggested Antigen Peptide Sequences for KBTBD12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 4 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with KBTBD12: view

Function for KBTBD12 Gene

Gene Ontology (GO) - Molecular Function for KBTBD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD12: view

Phenotypes for KBTBD12 Gene

GenomeRNAi human phenotypes for KBTBD12:
genes like me logo Genes that share phenotypes with KBTBD12: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KBTBD12 Gene

Localization for KBTBD12 Gene

Subcellular locations from

Jensen Localization Image for KBTBD12 Gene COMPARTMENTS Subcellular localization image for KBTBD12 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KBTBD12 Gene

Pathways for KBTBD12 Gene

SuperPathways for KBTBD12 Gene

No Data Available

Interacting Proteins for KBTBD12 Gene

Gene Ontology (GO) - Biological Process for KBTBD12 Gene


No data available for Pathways by source for KBTBD12 Gene

Transcripts for KBTBD12 Gene

mRNA/cDNA for KBTBD12 Gene

Unigene Clusters for KBTBD12 Gene

Kelch repeat and BTB (POZ) domain containing 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KBTBD12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD12 Gene

No ASD Table

Relevant External Links for KBTBD12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD12 Gene

mRNA expression in normal human tissues for KBTBD12 Gene

mRNA differential expression in normal tissues according to GTEx for KBTBD12 Gene

This gene is overexpressed in Muscle - Skeletal (12.7) and Heart - Left Ventricle (8.8).

Protein differential expression in normal tissues for KBTBD12 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KBTBD12 Gene

SOURCE GeneReport for Unigene cluster for KBTBD12 Gene Hs.132087

genes like me logo Genes that share expressions with KBTBD12: view

Expression partners for KBTBD12 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KBTBD12 Gene

Orthologs for KBTBD12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KBTBD12 35
  • 81.43 (n)
  • 88.57 (a)
KBTBD12 36
  • 88 (a)
(Canis familiaris)
Mammalia KBTBD12 35
  • 91.87 (n)
  • 94.06 (a)
KBTBD12 36
  • 94 (a)
(Mus musculus)
Mammalia Kbtbd12 35
  • 87.22 (n)
  • 92.11 (a)
Kbtbd12 16
Kbtbd12 36
  • 89 (a)
(Pan troglodytes)
Mammalia KBTBD12 35
  • 99.73 (n)
  • 99.36 (a)
KBTBD12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Kbtbd12 35
  • 86.55 (n)
  • 90.84 (a)
(Monodelphis domestica)
Mammalia KBTBD12 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 87 (a)
(Gallus gallus)
Aves KBTBD12 35
  • 75.28 (n)
  • 75.44 (a)
KBTBD12 36
  • 73 (a)
(Anolis carolinensis)
Reptilia KBTBD12 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd12 35
  • 68.36 (n)
  • 68.41 (a)
(Danio rerio)
Actinopterygii kbtbd12 35
  • 60 (n)
  • 57.38 (a)
kbtbd12 36
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for KBTBD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD12 Gene

Gene Tree for KBTBD12 (if available)
Gene Tree for KBTBD12 (if available)

Paralogs for KBTBD12 Gene

(2) SIMAP similar genes for KBTBD12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KBTBD12: view

Variants for KBTBD12 Gene

Sequence variations from dbSNP and Humsavar for KBTBD12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs112243820 -- 127,920,485(+) TTTTT(A/G)CTATT intron-variant
rs112402993 -- 127,958,280(+) CATTC(A/G)TCTGC intron-variant
rs112211470 -- 127,956,752(+) ACAAC(A/T)ATACA intron-variant
rs112154956 -- 127,970,899(+) AAAAA(A/C)CATTT intron-variant
rs112058793 -- 127,914,283(+) ACAAT(A/G)AATTT upstream-variant-2KB

Relevant External Links for KBTBD12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KBTBD12 Gene

Disorders for KBTBD12 Gene

Relevant External Links for KBTBD12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KBTBD12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KBTBD12 Gene

Publications for KBTBD12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for KBTBD12 Gene

Sources for KBTBD12 Gene

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