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Aliases for KBTBD11 Gene

Aliases for KBTBD11 Gene

  • Kelch Repeat And BTB Domain Containing 11 2 3
  • Kelch Repeat And BTB (POZ) Domain Containing 11 2 3 5
  • Chronic Myelogenous Leukemia-Associated Protein 3 4
  • Kelch Domain-Containing Protein 7B 3 4
  • KLHDC7C 3 4
  • KIAA0711 4
  • CMLAP 4

External Ids for KBTBD11 Gene

Previous GeneCards Identifiers for KBTBD11 Gene

  • GC08U900604
  • GC08P001912
  • GC08P001764

Summaries for KBTBD11 Gene

GeneCards Summary for KBTBD11 Gene

KBTBD11 (Kelch Repeat And BTB Domain Containing 11) is a Protein Coding gene. Diseases associated with KBTBD11 include dyskinesia of esophagus. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD11 Gene

Genomics for KBTBD11 Gene

Regulatory Elements for KBTBD11 Gene

Genomic Location for KBTBD11 Gene

1,970,710 bp from pter
2,006,943 bp from pter
36,234 bases
Plus strand

Genomic View for KBTBD11 Gene

Genes around KBTBD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD11 Gene

Proteins for KBTBD11 Gene

  • Protein details for KBTBD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch repeat and BTB domain-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • Q3L1I0

    Protein attributes for KBTBD11 Gene

    623 amino acids
    Molecular mass:
    65720 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34431.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KBTBD11 Gene

Proteomics data for KBTBD11 Gene at MOPED

Post-translational modifications for KBTBD11 Gene

  • Ubiquitination at Lys 244 and Lys 614
  • Modification sites at PhosphoSitePlus

Other Protein References for KBTBD11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KBTBD11

No data available for DME Specific Peptides for KBTBD11 Gene

Domains & Families for KBTBD11 Gene

Gene Families for KBTBD11 Gene

Protein Domains for KBTBD11 Gene

Suggested Antigen Peptide Sequences for KBTBD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 4 Kelch repeats.
  • Contains 1 BTB (POZ) domain.
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with KBTBD11: view

Function for KBTBD11 Gene

Gene Ontology (GO) - Molecular Function for KBTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KBTBD11: view
genes like me logo Genes that share phenotypes with KBTBD11: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD11 Gene

Localization for KBTBD11 Gene

Subcellular locations from

Jensen Localization Image for KBTBD11 Gene COMPARTMENTS Subcellular localization image for KBTBD11 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KBTBD11 Gene

Pathways & Interactions for KBTBD11 Gene

SuperPathways for KBTBD11 Gene

No Data Available

Interacting Proteins for KBTBD11 Gene

Gene Ontology (GO) - Biological Process for KBTBD11 Gene


No data available for Pathways by source and SIGNOR curated interactions for KBTBD11 Gene

Drugs & Compounds for KBTBD11 Gene

No Compound Related Data Available

Transcripts for KBTBD11 Gene

mRNA/cDNA for KBTBD11 Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD11 Gene

Kelch repeat and BTB (POZ) domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD11 Gene

No ASD Table

Relevant External Links for KBTBD11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KBTBD11 Gene

mRNA expression in normal human tissues for KBTBD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KBTBD11 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6), Brain - Cortex (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for KBTBD11 Gene

This gene is overexpressed in Frontal cortex (23.8), Brain (14.6), Spinal cord (12.7), and Fetal Brain (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KBTBD11 Gene

SOURCE GeneReport for Unigene cluster for KBTBD11 Gene Hs.5333

genes like me logo Genes that share expression patterns with KBTBD11: view

Protein tissue co-expression partners for KBTBD11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KBTBD11 Gene

Orthologs for KBTBD11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC518907 35
  • 86.1 (n)
  • 83.22 (a)
KBTBD11 36
  • 81 (a)
(Mus musculus)
Mammalia Kbtbd11 35
  • 82.07 (n)
  • 82.39 (a)
Kbtbd11 16
Kbtbd11 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Kbtbd11 35
  • 81.8 (n)
  • 82.23 (a)
(Monodelphis domestica)
Mammalia KBTBD11 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia KBTBD11 36
  • 58 (a)
(Pan troglodytes)
Mammalia KBTBD11 36
  • 99 (a)
(Gallus gallus)
Aves KBTBD11 35
  • 68.24 (n)
  • 65.7 (a)
KBTBD11 36
  • 59 (a)
(Anolis carolinensis)
Reptilia KBTBD11 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd11 35
  • 59.51 (n)
  • 54.43 (a)
(Danio rerio)
Actinopterygii LOC557467 35
  • 56.46 (n)
  • 53.74 (a)
KBTBD11 36
  • 52 (a)
Species with no ortholog for KBTBD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD11 Gene

Gene Tree for KBTBD11 (if available)
Gene Tree for KBTBD11 (if available)

Paralogs for KBTBD11 Gene

(1) SIMAP similar genes for KBTBD11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KBTBD11: view

Variants for KBTBD11 Gene

Sequence variations from dbSNP and Humsavar for KBTBD11 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs12566 -- 2,006,856(+) TAAAA(C/T)CCTGG utr-variant-3-prime
rs1043221 -- 2,004,876(+) CACAC(C/T)GTCCT utr-variant-3-prime
rs1043223 -- 2,005,057(+) TTAGG(C/T)TTCCA utr-variant-3-prime
rs1043225 -- 2,005,401(+) TGCCA(A/C/T)GCCAT utr-variant-3-prime
rs1043226 -- 2,005,593(+) TTCCA(A/T)TTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KBTBD11 Gene

Variant ID Type Subtype PubMed ID
dgv7588n71 CNV Gain 21882294
nsv889712 CNV Gain 21882294
dgv7592n71 CNV Gain 21882294
nsv889724 CNV Gain 21882294
nsv889729 CNV Gain 21882294
dgv7596n71 CNV Loss 21882294
dgv7598n71 CNV Loss 21882294
dgv1161n67 CNV Gain 20364138
dgv7599n71 CNV Loss 21882294
esv6680 CNV Gain 19470904
dgv7600n71 CNV Gain 21882294
esv28022 CNV Loss 19812545
esv1613551 CNV Deletion 17803354
esv1657589 CNV Deletion 17803354
esv22610 CNV Loss 19812545
dgv1261e199 CNV Deletion 23128226
esv26547 CNV Loss 19812545
nsv528662 CNV Loss 19592680

Variation tolerance for KBTBD11 Gene

Gene Damage Index Score: 1.43; 28.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD11 Gene

Disorders for KBTBD11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KBTBD11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyskinesia of esophagus
  • dyskinesia of oesophagus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KBTBD11

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KBTBD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KBTBD11 Gene

Publications for KBTBD11 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 67
  2. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3
  5. Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. (PMID: 14508709) Verhoeven K. … Timmerman V. (Am. J. Hum. Genet. 2003) 3

Products for KBTBD11 Gene

Sources for KBTBD11 Gene

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