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Aliases for KBTBD11 Gene

Aliases for KBTBD11 Gene

  • Kelch Repeat And BTB (POZ) Domain Containing 11 2 3
  • Chronic Myelogenous Leukemia-Associated Protein 3 4
  • Kelch Domain-Containing Protein 7B 3 4
  • KLHDC7C 3 4
  • KIAA0711 4
  • CMLAP 4

External Ids for KBTBD11 Gene

Previous GeneCards Identifiers for KBTBD11 Gene

  • GC08U900604
  • GC08P001912
  • GC08P001764

Summaries for KBTBD11 Gene

GeneCards Summary for KBTBD11 Gene

KBTBD11 (Kelch Repeat And BTB (POZ) Domain Containing 11) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KBTBD11 Gene

Genomics for KBTBD11 Gene

Regulatory Elements for KBTBD11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KBTBD11 Gene

Chromosome:
8
Start:
1,970,710 bp from pter
End:
2,006,943 bp from pter
Size:
36,234 bases
Orientation:
Plus strand

Genomic View for KBTBD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KBTBD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD11 Gene

Proteins for KBTBD11 Gene

  • Protein details for KBTBD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94819-KBTBB_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 11
    Protein Accession:
    O94819
    Secondary Accessions:
    • Q3L1I0

    Protein attributes for KBTBD11 Gene

    Size:
    623 amino acids
    Molecular mass:
    65720 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34431.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KBTBD11 Gene

Proteomics data for KBTBD11 Gene at MOPED

Post-translational modifications for KBTBD11 Gene

  • Ubiquitination at Lys 244 and Lys 614
  • Modification sites at PhosphoSitePlus

Other Protein References for KBTBD11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD11 Gene

Domains & Families for KBTBD11 Gene

Gene Families for KBTBD11 Gene

Protein Domains for KBTBD11 Gene

Suggested Antigen Peptide Sequences for KBTBD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94819

UniProtKB/Swiss-Prot:

KBTBB_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 4 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with KBTBD11: view

Function for KBTBD11 Gene

Gene Ontology (GO) - Molecular Function for KBTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KBTBD11: view
genes like me logo Genes that share phenotypes with KBTBD11: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD11 Gene

Localization for KBTBD11 Gene

Gene Ontology (GO) - Cellular Components for KBTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KBTBD11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KBTBD11 Gene

Pathways & Interactions for KBTBD11 Gene

SuperPathways for KBTBD11 Gene

No Data Available

Interacting Proteins for KBTBD11 Gene

Gene Ontology (GO) - Biological Process for KBTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with KBTBD11: view

No data available for Pathways by source and SIGNOR curated interactions for KBTBD11 Gene

Drugs & Compounds for KBTBD11 Gene

No Compound Related Data Available

Transcripts for KBTBD11 Gene

mRNA/cDNA for KBTBD11 Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KBTBD11 Gene

Kelch repeat and BTB (POZ) domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KBTBD11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD11 Gene

No ASD Table

Relevant External Links for KBTBD11 Gene

GeneLoc Exon Structure for
KBTBD11
ECgene alternative splicing isoforms for
KBTBD11

Expression for KBTBD11 Gene

mRNA expression in normal human tissues for KBTBD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KBTBD11 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6), Brain - Cortex (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for KBTBD11 Gene

This gene is overexpressed in Frontal cortex (23.8), Brain (14.6), Spinal cord (12.7), and Fetal Brain (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KBTBD11 Gene



SOURCE GeneReport for Unigene cluster for KBTBD11 Gene Hs.5333

genes like me logo Genes that share expression patterns with KBTBD11: view

Protein tissue co-expression partners for KBTBD11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KBTBD11 Gene

Orthologs for KBTBD11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC518907 35
  • 86.1 (n)
  • 83.22 (a)
KBTBD11 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kbtbd11 35
  • 82.07 (n)
  • 82.39 (a)
Kbtbd11 16
Kbtbd11 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kbtbd11 35
  • 81.8 (n)
  • 82.23 (a)
oppossum
(Monodelphis domestica)
Mammalia KBTBD11 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KBTBD11 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KBTBD11 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves KBTBD11 35
  • 68.24 (n)
  • 65.7 (a)
KBTBD11 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KBTBD11 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kbtbd11 35
  • 59.51 (n)
  • 54.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557467 35
  • 56.46 (n)
  • 53.74 (a)
KBTBD11 36
  • 52 (a)
OneToOne
Species with no ortholog for KBTBD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KBTBD11 Gene

ENSEMBL:
Gene Tree for KBTBD11 (if available)
TreeFam:
Gene Tree for KBTBD11 (if available)

Paralogs for KBTBD11 Gene

(1) SIMAP similar genes for KBTBD11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KBTBD11: view

Variants for KBTBD11 Gene

Sequence variations from dbSNP and Humsavar for KBTBD11 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs12566 -- 2,006,856(+) TAAAA(C/T)CCTGG utr-variant-3-prime
rs1043221 -- 2,004,876(+) CACAC(C/T)GTCCT utr-variant-3-prime
rs1043223 -- 2,005,057(+) TTAGG(C/T)TTCCA utr-variant-3-prime
rs1043225 -- 2,005,401(+) TGCCA(A/C/T)GCCAT utr-variant-3-prime
rs1043226 -- 2,005,593(+) TTCCA(A/T)TTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KBTBD11 Gene

Variant ID Type Subtype PubMed ID
dgv7588n71 CNV Gain 21882294
nsv889712 CNV Gain 21882294
dgv7592n71 CNV Gain 21882294
nsv889724 CNV Gain 21882294
nsv889729 CNV Gain 21882294
dgv7596n71 CNV Loss 21882294
dgv7598n71 CNV Loss 21882294
dgv1161n67 CNV Gain 20364138
dgv7599n71 CNV Loss 21882294
esv6680 CNV Gain 19470904
dgv7600n71 CNV Gain 21882294
esv28022 CNV Loss 19812545
esv1613551 CNV Deletion 17803354
esv1657589 CNV Deletion 17803354
esv22610 CNV Loss 19812545
dgv1261e199 CNV Deletion 23128226
esv26547 CNV Loss 19812545
nsv528662 CNV Loss 19592680

Variation tolerance for KBTBD11 Gene

Gene Damage Index Score: 1.43; 28.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KBTBD11 Gene

HapMap Linkage Disequilibrium report
KBTBD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KBTBD11 Gene

Disorders for KBTBD11 Gene

Relevant External Links for KBTBD11

Genetic Association Database (GAD)
KBTBD11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KBTBD11
genes like me logo Genes that share disorders with KBTBD11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD11 Gene

Publications for KBTBD11 Gene

  1. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 67
  5. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PMID: 17052657) Fung H.C. … Singleton A. (Lancet Neurol 2006) 67

Products for KBTBD11 Gene

Sources for KBTBD11 Gene

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