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Aliases & Descriptions for KBTBD10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KRP1 3 | | OTTHUMP00000163060 2 | | SARCOSIN 1, 2 | | Sarcosin 3 |
| | | Descriptions |
|---|
| Kel-like protein 23 3 | | Kelch-related protein 1 3 | | kelch repeat and BTB (POZ) domain containing 10 2 | | kelch repeat and BTB domain containing 10 1 | | sarcomeric muscle protein 2 |
|
| | Search outside databases for aliases for KBTBD10 genePrevious GC identifers: GC02P170568 GC02P170191 |
Summaries for KBTBD10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662Function: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteinsGene Wiki entry for KBTBD10 |
Genomic Location for KBTBD10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KBTBD10 gene 
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2p14-q14.3KBTBD10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P170074:
(about GC identifiers)
Start:
|
170,074,458 bp from pter |
End:
|
170,091,018 bp from pter |
Size:
|
16,561 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for KBTBD10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662 (See
protein sequence)Recommended Name: Kelch repeat and BTB domain-containing protein 10 Size: 606 amino acids; 68037 Da
Subunit: Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle. Note=Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia
Secondary accessions: Q53R42Alternative splicing: 2 isoforms: O60662-1 O60662-2 Post-translational modifications:
Ubiquitinated and probably targeted for proteasome-independent degradation1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006054.2
ENSEMBL proteins: ENSP00000284669
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KBTBD10: Assays for KBTBD10: | Protein
Domains/ Families for KBTBD10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60662
ProtoNet protein and cluster: O60662 4 Blocks protein families: IPB000210 BTB/POZ domain IPB001497 Methylated-DNA-[protein]-cysteine S-methyltransferase IPB006651 Kelch repeat signature IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 Kelch repeats | Gene Function for KBTBD10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006063
Applied Biosystems Silencer® siRNAs for KBTBD10
Sigma-Aldrich siRNA and siRNA Panels for KBTBD10  Sigma-Aldrich shRNA for KBTBD10  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006063                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006063                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006063 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006063
UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662Function: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for KBTBD10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662Pathway: Protein modification; protein ubiquitination2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006941 | striated muscle contraction |
TAS | 9655184 | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for KBTBD10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for KBTBD10
|
Transcripts for KBTBD10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006063
Sigma-Aldrich siRNA and siRNA Panels for KBTBD10  Sigma-Aldrich shRNA for KBTBD10  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006063 REFSEQ mRNAs for KBTBD10 gene: NM_006063.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006063               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006063                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006063                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006063  Additional cDNA sequence: AF056929.1 AF333387.1 AK316571.1 AY364252.1 BC006534.2 6 DOTS entries: DT.318408 DT.100781183 DT.120973591 DT.100781185 DT.95358215 DT.95370555 24/236 AceView cDNA sequences (see all 236
):AA393742 NM_006063 BM142673 AI668950 AI131111 BC006534 AA653726 BX641882 CB857422 BM977128 BU737302 AA418529 W21178 BX099518 F29300 BE250269 AI695762 AF333387 BQ960982 AU121012 BU581368 AI144214 AI367745 BI793162
highest scoring ESTs for KBTBD10:AA213904 AA055063 AA086230 AA086338 AA086367 AA086385 AA181365 AA192617 AA192620 AA193197 Unigene Cluster for KBTBD10: Kelch repeat and BTB (POZ) domain containing 10 Hs.50550 [show with all ESTs]Unigene Representative Sequence: NM_006063
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD10
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | |
| SP1: | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KBTBD10
1 Ensembl transcript including schematic representation: ENST00000284669
|
Expression for KBTBD10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KBTBD10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KBTBD10
1 / 2 / 3 6 probe-sets matching KBTBD10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCATAAGATG
SOURCE GeneReport for Unigene cluster: Hs.50550 UniProtKB/Swiss-Prot: KBTBA_HUMAN, O60662Tissue specificity: Sarcomeric muscle |
Orthologs for KBTBD10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KBTBD10 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for KBTBD10
ENSEMBL Gene Tree for KBTBD10 | Paralogs for KBTBD10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KBTBD10 gene
- KBTBD52 KBTBD82 KBTBD32 CCIN2
|
SNPs/Variants for KBTBD10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KBTBD10 (up to first 250kb)
|
Disorders & Mutations for KBTBD10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607701
|
Medical News for KBTBD10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KBTBD10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for KBTBD10 gene (see all 12
):- DNA sequence and muscle-specific expression of human sarcosin transcripts. (PubMed id 9655184)2, 3, 4 Taylor A.... Carlson K.D. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells. (PubMed id 10713668)3, 4 Spence H.J....Ozanne B.W. (2000)
- Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). (PubMed id 16396496)3 Foster L.J....Klip A. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)4 Hillier L.W....Wilson R.K. (2005)
- Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. (PubMed id 15983046)4 Zhang D.D.... Hannink M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes. (PubMed id 11583900)3 Lim D.S....Marian A.J. (2001)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)3 Hillier L.D....Marra M. (1996)
- Apolipoprotein A-1 expression is resistant to dimethyl sulfoxide inhibition of myogenic differentiation. (PubMed id 1915663)1 Lourim D. and Lin J.J. (1991)
|
Search for KBTBD10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KBTBD10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KBTBD10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KBTBD10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KBTBD10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KBTBD10:

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Incremental update: 13 Oct 2009
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