 |
 | Services
| |
 |
Aliases & Descriptions for KAZALD1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BONO1 2 | | FKSG28 1, 2 | | FKSG40 1, 2 | | FLJ24094 2 | | IGFBP-rP10 2 | | OTTHUMP00000020298 2 |
| | | Descriptions |
|---|
| IGFBP-related protein 10 2 | | Kazal-type serine peptidase inhibitor domain 1 2 | | Kazal-type serine protease inhibitor domain 1 1, 2 | | bone- and odontoblast-expressed gene 1 2 | novel kazal-type serine protease inhibitor domain and immunoglobulin domain containing protein 2 |
|
| | Search outside databases for aliases for KAZALD1 genePrevious GC identifer: GC10P102487 |
Summaries for KAZALD1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KAZALD1: This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. It contains an N-terminal insulin growth factor-binding domain, a central Kazal-type serine protease inhibitor and follistatin-like domain, and a C-terminal immunoglobulin-like domain. Studies of the mouse ortholog suggest that this gene product may have a function in bone development and bone regeneration. [provided by RefSeq] UniProtKB/Swiss-Prot: KAZD1_HUMAN, Q96I82Function: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity)Gene Wiki entry for KAZALD1 |
Genomic Location for KAZALD1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KAZALD1 gene 
Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.32KAZALD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P102810:
(about GC identifiers)
Start:
|
102,811,588 bp from pter |
End:
|
102,817,878 bp from pter |
Size:
|
6,291 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for KAZALD1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KAZD1_HUMAN, Q96I82 (See
protein sequence)Recommended Name: Kazal-type serine protease inhibitor domain-containing protein 1 precursor Size: 304 amino acids; 32945 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q6ZMB1 Q9BQ73Alternative splicing: 2 isoforms: Q96I82-1 Q96I82-2 REFSEQ proteins: NP_112191.2
ENSEMBL proteins: ENSP00000313288 ENSP00000359218 ENSP00000359219
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
IEA | -- | About this table
Antibodies for KAZALD1: Assays for KAZALD1: | Protein
Domains/ Families for KAZALD1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96I82
ProtoNet protein and cluster: Q96I82 3 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB011497 Protease inhibitor IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: KAZD1_HUMAN, Q96I82Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 IGFBP N-terminal domainSimilarity: Contains 1 Kazal-like domain | Gene Function for KAZALD1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030929
Applied Biosystems Silencer® siRNAs for KAZALD1
Sigma-Aldrich siRNA for KAZALD1  Sigma-Aldrich shRNA for KAZALD1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030929                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030929                                  untagged cDNA clone in CMV expression vector: NM_030929 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030929
UniProtKB/Swiss-Prot: KAZD1_HUMAN, Q96I82Function: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity)1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005520 | insulin-like growth factor binding |
IEA | -- | About this table | Pathways & Interactions for KAZALD1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001503 | ossification |
IEA | -- | | GO:0001558 | regulation of cell growth |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- | About this table
|
Drugs & Compounds for KAZALD1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for KAZALD1
|
Transcripts for KAZALD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030929
Sigma-Aldrich siRNA for KAZALD1  Sigma-Aldrich shRNA for KAZALD1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_030929 REFSEQ mRNAs for KAZALD1 gene: NM_030929.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_030929               OriGene GFP tagged cDNA clone in CMV expression vector: NM_030929                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030929                                  untagged cDNA clone in CMV expression vector: NM_030929  Additional cDNA sequence: AK172862.1 AK172864.1 AK225949.1 AY359087.1 BC007758.2 BC012394.1 BC053611.1 8 DOTS entries: DT.95264894 DT.100000179 DT.92032324 DT.100016945 DT.121267200 DT.97839455 DT.100020684 DT.92052860 24/75 AceView cDNA sequences (see all 75
):BQ943656 BC053611 BM709870 AI658885 BC007758 BU619382 AK172862 NM_030929 BG030637 BQ017738 BM976051 BU734232 BI766345 CA419201 CA393819 BF434771 BI834297 AI075710 AW205863 BQ014317 BP357463 AI377545 BM749471 AI612949
highest scoring ESTs for KAZALD1:AI075710 AA688321 AA896981 AF333487 AK172862 AY014271 AY359087 BC007758 BI766345 BI838313 Unigene Cluster for KAZALD1: Kazal-type serine peptidase inhibitor domain 1 Hs.632079 [show with all ESTs]Unigene Representative Sequence: AK172864
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KAZALD1 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KAZALD1
3 Ensembl transcripts including schematic representations: ENST00000313664
ENST00000370199
ENST00000370200
|
Expression for KAZALD1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KAZALD1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KAZALD1
1 / 2 / 3 7 probe-sets matching KAZALD1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.632079
Expression variation in blood from EXPOLDB for KAZALD1 |
Orthologs for KAZALD1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KAZALD1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for KAZALD1
ENSEMBL Gene Tree for KAZALD1 | Paralogs for KAZALD1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KAZALD1 gene
- IGFBP72 IGFBPL12
|
SNPs/Variants for KAZALD1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KAZALD1 (up to first 250kb)
|
Disorders & Mutations for KAZALD1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609208
|
Medical News for KAZALD1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KAZALD1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for KAZALD1 gene (see all 12
):- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)2, 3, 4 Clark H.F....Gray A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- Bono1: a gene associated with regions of deposition of bone and dentine. (PubMed id 15261838)1, 3 James M.J....Thesleff I. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells. (PubMed id 15555553)3 Shibata Y....Yamaguchi A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
|
Search for KAZALD1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KAZALD1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KAZALD1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KAZALD1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KAZALD1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KAZALD1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for KAZALD1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|