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KATNBL1 Gene

protein-coding   GIFtS: 41
GCID: GC15M034433

Katanin P80 Subunit B-Like 1

(Previous name: chromosome 15 open reading frame 29)
(Previous symbol: C15orf29)
  Search for KATNBL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Katanin P80 Subunit B-Like 11 2 3
C15orf291 2 3
Chromosome 15 Open Reading Frame 291
KATNB1-Like Protein 12

External Ids:    HGNC: 261991   Entrez Gene: 797682   Ensembl: ENSG000001341527   UniProtKB: Q9H0793   
ORGUL members:         

Export aliases for KATNBL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KATNBL1 Gene:
KATNBL1 (katanin p80 subunit B-like 1) is a protein-coding gene.

Gene Wiki entry for KATNBL1 (C15orf29) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KATNBL1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KATNBL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KATNBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.2

KATNBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KATNBL1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M034433:  view genomic region     (about GC identifiers)

Start:
34,432,875 bp from pter      End:
34,502,297 bp from pter
Size:
69,423 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KTBL1_HUMAN, Q9H079 (See protein sequence)
Recommended Name: KATNB1-like protein 1  
Size: 304 amino acids; 34767 Da
Sequence caution: Sequence=BAB15394.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8KAF6 Q2TAC0 Q9H670

Explore the universe of human proteins at neXtProt for KATNBL1: NX_Q9H079

Explore proteomics data for KATNBL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KATNBL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078989.1  
    ENSEMBL proteins: 
     ENSP00000256544   ENSP00000453072   ENSP00000453383   ENSP00000453713   ENSP00000454181  
     ENSP00000452963   ENSP00000454010   ENSP00000453996   ENSP00000453991   ENSP00000453283  

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    Search eBioscience for ELISAs for KATNBL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028021 Katanin_C-terminal

    Graphical View of Domain Structure for InterPro Entry Q9H079

    ProtoNet protein and cluster: Q9H079


    Find genes that share domains with KATNBL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for KATNBL1:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KATNBL1
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    miRNA
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    miRTarBase miRNAs that target KATNBL1:
    hsa-mir-100-5p (MIRT048432)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with KATNBL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KATNBL1
    Interactions:

        Search GeneGlobe Interaction Network for KATNBL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for KATNBL1 (Q9H0792, 3 ENSP000002565444) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA12O435702, 3, ENSP000001786384MINT-65435 I2D: score=4 STRING: ENSP00000178638
    KAT7O952512, 3MINT-65436 I2D: score=5 
    HAP1P542572, 3MINT-65437 I2D: score=4 
    PDPK1O155302, 3MINT-8265464 I2D: score=2 
    YWHAEP622583I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KATNBL1 (KTBL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KATNBL1 gene: 
    NM_024713.2  

    Unigene Cluster for KATNBL1:

    Katanin p80 subunit B-like 1
    Hs.633566  [show with all ESTs]
    Unigene Representative Sequence: NM_024713
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256544(uc001zhp.3) ENST00000561270 ENST00000558681 ENST00000561371
    ENST00000559760 ENST00000560247(uc010ubz.2) ENST00000540594 ENST00000560308
    ENST00000560310 ENST00000560671(uc010uca.1) ENST00000558473 ENST00000557877
    ENST00000559462 ENST00000560108 ENST00000559515 ENST00000559464 ENST00000560915

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate KATNBL1
    SwitchGear 3'UTR luciferase reporter plasmidKATNBL1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat KATNBL1
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    Primer
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    OriGene qPCR primer pairs and template standards for KATNBL1
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KATNBL1
      QuantiTect SYBR Green Assays in human, mouse, rat KATNBL1
      QuantiFast Probe-based Assays in human, mouse, rat KATNBL1

    Additional mRNA sequence: 

    AK021466.1 AK026210.1 AK293021.1 AK293695.1 AK297904.1 AK311338.1 AL136908.1 AL833631.1 
    BC026234.1 BC037234.1 BC047748.1 BC111000.1 

    16 DOTS entries:

    DT.455700  DT.427775  DT.95187408  DT.100776935  DT.86846668  DT.95231632  DT.99968180  DT.121073471 
    DT.40121061  DT.97824244  DT.100762381  DT.121073472  DT.214511  DT.91737617  DT.121073449  DT.301710 

    Selected AceView cDNA sequences (see all 212):

    BQ009192 BM666514 AI094237 BU687040 BQ004814 NM_024713 CR596194 BG619947 
    AL524646 BQ100984 BF222693 AI439859 BM983609 BC047748 BM822873 AA127879 
    AA457030 CA390186 AU135244 AI696465 BM920715 AA970164 AI288863 AA127929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KATNBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KATNBL1 Expression
    About this image

    KATNBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KATNBL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633566
        Custom PCR Arrays for KATNBL1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KATNBL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Katnbl11 , 5 RIKEN cDNA 2410042D21 gene5
    katanin p80 subunit B like 11
    88.85(n)1
    87.63(a)1
      2 (57.02 cM)5
    724251  NM_024254.31  NP_077216.11 
     1123792115 
    chicken
    (Gallus gallus)
    Aves C5H15ORF291 chromosome 5 open reading frame, human C15orf29 79.84(n)
    77.08(a)
      423287  NM_001031198.1  NP_001026369.1 
    lizard
    (Anolis carolinensis)
    Reptilia KATNBL16
    katanin p80 subunit B-like 1
    67(a)
    1 ↔ 1
    1(33720336-33766149)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX746175.12   -- 75(n)    BX746175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc76b102 Transcribed sequence with weak similarity to protein more 69.71(n)    57052420 


    ENSEMBL Gene Tree for KATNBL1 (if available)
    TreeFam Gene Tree for KATNBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KATNBL1 gene
    2 SIMAP similar genes for KATNBL1 using alignment to 10 protein entries:     KTBL1_HUMAN (see all proteins):
    SDCCAG8    C6orf149

    Find genes that share paralogs with KATNBL1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for KATNBL1 (see all 6)
    PGOHUM00000248552 PGOHUM00000262127 PGOHUM00000244114 PGOHUM00000235582 PGOHUM00000243410


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KATNBL1 (see all 1570)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs597072581,2
    C--11328552(+) CACAC-/AC    
       
    /ACAC
    GCTTC
    1 -- int11NA 2
    rs671115521,2
    C--14540877(+) ATATA-/TGGACAT 1 -- int10--------
    rs1434322361,2
    --34432497(+) ACCCAA/GAGAAA 1 -- ds50010--------
    rs1414323471,2
    C--34432569(+) TTTAG-/ATATCTT 1 -- ds50010--------
    rs733761581,2
    C,F--34432854(+) ACATAG/AGACAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1402724931,2
    C--34433061(+) ATTCAC/TGTTCA 1 -- ut310--------
    rs1895055601,2
    --34433085(+) CTAGCC/TATATA 1 -- ut310--------
    rs1806940291,2
    --34433126(+) GAAACA/GTAACT 1 -- ut310--------
    rs1424742481,2
    --34433168(+) ATCAGC/TAGTCA 1 -- ut310--------
    rs1860807511,2
    --34433262(+) AGATGC/TCTGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KATNBL1 (34432875 - 34502297 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KATNBL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KATNBL1
    DNA2.0 Custom Variant and Variant Library Synthesis for KATNBL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KATNBL1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with KATNBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity. (PubMed id 21372175)1 McNally K.P. and McNally F.J. (Mol. Biol. Cell 2011)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79768 HGNC: 26199 AceView: C15orf29 Ensembl:ENSG00000134152 euGenes: HUgn79768
    ECgene: KATNBL1 H-InvDB: KATNBL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KATNBL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KATNBL1 gene:
    Search GeneIP for patents involving KATNBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search Addgene for plasmids for KATNBL1
      Search eBioscience for proteins for KATNBL1
      Search eBioscience for elisas for KATNBL1
      eBioscience FlowRNA Probe Sets
           
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