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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KATNBL1 Gene

protein-coding   GIFtS: 41
GCID: GC15M034433

Katanin P80 Subunit B-Like 1

(Previous name: chromosome 15 open reading frame 29)
(Previous symbol: C15orf29)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Katanin P80 Subunit B-Like 11 2 3
C15orf291 2 3
Chromosome 15 Open Reading Frame 291
KATNB1-Like Protein 12

External Ids:    HGNC: 261991   Entrez Gene: 797682   Ensembl: ENSG000001341527   UniProtKB: Q9H0793   

Export aliases for KATNBL1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KATNBL1 Gene: 
KATNBL1 (katanin p80 subunit B-like 1) is a protein-coding gene. Diseases associated with KATNBL1 include gastric cancer.

Gene Wiki entry for KATNBL1 (C15orf29) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KATNBL1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KATNBL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.2

KATNBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KATNBL1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M034433:  view genomic region     (about GC identifiers)

Start:
34,432,875 bp from pter      End:
34,502,297 bp from pter
Size:
69,423 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KTBL1_HUMAN, Q9H079 (See protein sequence)
Recommended Name: KATNB1-like protein 1  
Size: 304 amino acids; 34767 Da
Sequence caution: Sequence=BAB15394.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8KAF6 Q2TAC0 Q9H670

Explore the universe of human proteins at neXtProt for KATNBL1: NX_Q9H079

Explore proteomics data for KATNBL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H079

  • KATNBL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KATNBL1 Protein Expression
    REFSEQ proteins: NP_078989.1  
    ENSEMBL proteins: 
     ENSP00000256544   ENSP00000453072   ENSP00000453383   ENSP00000453713   ENSP00000454181  
     ENSP00000452963   ENSP00000454010   ENSP00000453996   ENSP00000453991   ENSP00000453283  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    KATNBL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H079


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for KATNBL1:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KATNBL1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KATNBL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for KATNBL1 (Q9H0792, 3 ENSP000002565444) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA12O435702, 3, ENSP000001786384MINT-65435 I2D: score=4 STRING: ENSP00000178638
    KAT7O952512, 3MINT-65436 I2D: score=5 
    HAP1P542572, 3MINT-65437 I2D: score=4 
    PDPK1O155302, 3MINT-8265464 I2D: score=2 
    YWHAEP622583I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KATNBL1 (KTBL1)

    Search CenterWatch for drugs/clinical trials and news about KATNBL1 / KTBL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KATNBL1 gene: 
    NM_024713.2  

    Unigene Cluster for KATNBL1:

    Katanin p80 subunit B-like 1
    Hs.633566  [show with all ESTs]
    Unigene Representative Sequence: NM_024713
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256544(uc001zhp.3) ENST00000561270 ENST00000558681 ENST00000561371
    ENST00000559760 ENST00000560247(uc010ubz.2) ENST00000540594 ENST00000560308
    ENST00000560310 ENST00000560671(uc010uca.1) ENST00000558473 ENST00000557877
    ENST00000559462 ENST00000560108 ENST00000559515 ENST00000559464 ENST00000560915

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKATNBL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KATNBL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KATNBL1
    Clone
    Products:
         
    OriGene clones in human, mouse for KATNBL1 (see all 8)
    OriGene ORF clones in mouse, rat for KATNBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KATNBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNBL1
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                         Customized lentivirus expression plasmids for stable overexpression of KATNBL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KATNBL1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KATNBL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KATNBL1

    Additional mRNA sequence: 

    AK021466.1 AK026210.1 AK293021.1 AK293695.1 AK297904.1 AK311338.1 AL136908.1 AL833631.1 
    BC026234.1 BC037234.1 BC047748.1 BC111000.1 

    16 DOTS entries:

    DT.455700  DT.427775  DT.95187408  DT.100776935  DT.86846668  DT.95231632  DT.99968180  DT.121073471 
    DT.40121061  DT.97824244  DT.100762381  DT.121073472  DT.214511  DT.91737617  DT.121073449  DT.301710 

    24/212 AceView cDNA sequences (see all 212):

    BC047748 AA781677 BG619947 AA604434 CR605900 AI784670 AI696465 BQ004814 
    AA970164 BM126260 AI419012 AI091568 AA457030 AV652434 BM666514 BI870277 
    CR596194 BI766353 AA127879 AA845544 AA456874 BF222693 AI299528 NM_024713 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KATNBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KATNBL1 Expression
    About this image


    See KATNBL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KATNBL1

    SOURCE GeneReport for Unigene cluster: Hs.633566
        SABiosciences Custom PCR Arrays for KATNBL1
    Primer
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    OriGene qPCR primer pairs and template standards for KATNBL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KATNBL1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Katnbl11 , 5 RIKEN cDNA 2410042D21 gene5
    katanin p80 subunit B like 11
    88.85(n)1
    87.63(a)1
      2 (57.02 cM)5
    724251  NM_024254.31  NP_077216.11 
     1123792115 
    chicken
    (Gallus gallus)
    Aves KATNBL11 katanin p80 subunit B-like 1 79.84(n)
    77.08(a)
      423287  NM_001031198.1  NP_001026369.1 
    lizard
    (Anolis carolinensis)
    Reptilia C15ORF296
    Uncharacterized protein
    66(a)
    1 ↔ 1
    1(33720336-33766149)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX746175.12   -- 75(n)    BX746175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc76b102 Transcribed sequence with weak similarity to protein more 69.71(n)    57052420 


    ENSEMBL Gene Tree for KATNBL1 (if available)
    TreeFam Gene Tree for KATNBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KATNBL1 gene
    1 SIMAP similar gene for KATNBL1 using alignment to 10 protein entries:     KTBL1_HUMAN (see all proteins):
    C6orf149

    KATNBL1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for KATNBL1 (see all 6)
    PGOHUM00000248552 PGOHUM00000262127 PGOHUM00000244114 PGOHUM00000235582 PGOHUM00000243410


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1570 SNPs in KATNBL1 are shown (see all 1570)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs597072581,2
    C--11328552(+) CACAC-/AC    
       
    /ACAC
    GCTTC
    1 -- int11NA 2
    rs671115521,2
    C--14540877(+) ATATA-/TGGACAT 1 -- int10--------
    rs1434322361,2
    --34432497(+) ACCCAA/GAGAAA 1 -- ds50010--------
    rs1414323471,2
    C--34432569(+) TTTAG-/ATATCTT 1 -- ds50010--------
    rs733761581,2
    C,F--34432854(+) ACATAG/AGACAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1402724931,2
    C--34433061(+) ATTCAC/TGTTCA 1 -- ut310--------
    rs1895055601,2
    --34433085(+) CTAGCC/TATATA 1 -- ut310--------
    rs1806940291,2
    --34433126(+) GAAACA/GTAACT 1 -- ut310--------
    rs1424742481,2
    --34433168(+) ATCAGC/TAGTCA 1 -- ut310--------
    rs1860807511,2
    --34433262(+) AGATGC/TCTGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KATNBL1 (34432875 - 34502297 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KATNBL1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KATNBL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for KATNBL1:    About MalaCards
    gastric cancer    


    KATNBL1 for disorders           About GeneDecksing


    Export disorders for KATNBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KATNBL1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KATNBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The spindle assembly function of Caenorhabditis elegan s katanin does not require microtubule-severing activity. (PubMed id 21372175)1 McNally K.P. and McNally F.J. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79768 HGNC: 26199 AceView: C15orf29 Ensembl:ENSG00000134152 euGenes: HUgn79768
    ECgene: KATNBL1 H-InvDB: KATNBL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KATNBL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KATNBL1 gene:
    Search GeneIP for patents involving KATNBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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