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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KATNB1 Gene

protein-coding   GIFtS: 53
GCID: GC16P057770

katanin p80 (WD repeat containing) subunit B 1

(Previous name: katanin p80 (WD40-containing) subunit B 1 )
 Explore 6 diseases affiliated with
KATNB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KATNB1    

Aliases
for KATNB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Katanin P80 (WD Repeat Containing) Subunit B 11 2     KAT2
Katanin P80 (WD40-Containing) Subunit B 11 2     Katanin (80 KDa)2
Katanin P80 Subunit B12 3     Katanin P80 WD40 Repeat-Containing Subunit B12
P80 Katanin2 3     Katanin P80 WD40-Containing Subunit B12

External Ids:    HGNC: 62171   Entrez Gene: 103002   Ensembl: ENSG000001408547   OMIM: 6027035   UniProtKB: Q9BVA03   

Export aliases for KATNB1 gene to outside databases

Previous GC identifers: GC16P048165 GC16P057855 GC16P057505 GC16P057546 GC16P056328 GC16P043636


Summaries
for KATNB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KATNB1:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to
organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60
subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble
microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of
ATPases. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0
Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the
enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid
reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following
nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end
proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule
release within the cell body of neurons may be required for their transport into neuronal processes by
microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)

Gene Wiki entry for KATNB1


Genomic Views
for KATNB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KATNB1 gene promoter:
         Pbx1a   Nkx2-5   LCR-F1   CBF-A   CBF-B   ZID   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KATNB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KATNB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q12.2

KATNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KATNB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057770:  view genomic region     (about GC identifiers)

Start:
 57,769,642 bp from pter      End:
 57,791,162 bp from pter
Size:
 21,521 bases      Orientation:
 plus strand

Proteins
for KATNB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0 (See protein sequence)
Recommended Name: Katanin p80 WD40 repeat-containing subunit B1  
Size: 655 amino acids; 72334 Da
Subunit: Interacts with PAFAH1B1 (By similarity). Interacts with KATNA1. This interaction enhances the microtubule
binding and severing activity of KATNA1 and also targets this activity to the centrosome. Interacts with dynein,
microtubules and NDEL1
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm,
cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles
Secondary accessions: A6NCG6 O60620

Explore the universe of human proteins at neXtProt for KATNB1: NX_Q9BVA0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BVA0

    • KATNB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005877.2  
    ENSEMBL proteins: 
     ENSP00000368982   ENSP00000455350   ENSP00000455270   ENSP00000457347   ENSP00000457046  
     ENSP00000457334  

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    Uscn Proteins for KATNB1

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA10751153
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane IDA--


    KATNB1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KATNB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KATNB1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR019775 WD40_repeat_CS
     IPR026962 Katanin_bsu1
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BVA0

    ProtoNet protein and cluster: Q9BVA0

    UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0
    Similarity: Belongs to the WD repeat KATNB1 family
    Similarity: Contains 6 WD repeats


    Function
    for KATNB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0
    Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the
    enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid
    reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following
    nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end
    proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule
    release within the cell body of neurons may be required for their transport into neuronal processes by
    microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)

    miRNA
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    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmid: KATNB1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding NAS10751153
    GO:0008568contributes to microtubule-severing ATPase activity IDA10751153
    GO:0045502dynein binding IEA--
    GO:0046982protein heterodimerization activity IPI10751153


    KATNB1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for KATNB1:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M 
     Decreased number of cells in m 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Katnb1):
     endocrine/exocrine gland  reproductive system 

    KATNB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KATNB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KATNB1

    2 Interacting proteins for KATNB1 (Q9BVA03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1P368973I2D: score=3 
    KATNA1O754493I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting NAS10751153
    GO:0007026negative regulation of microtubule depolymerization IMP10751153
    GO:0007067mitosis IEA--
    GO:0010942positive regulation of cell death IEA--
    GO:0010976positive regulation of neuron projection development IEA--


    KATNB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KATNB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KATNB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KATNB1
    2 Novoseek chemical compound relationships for KATNB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cellulose 18.9 1 12215512 (1)
    atp 16.4 7 10531065 (2), 15823537 (1), 17178905 (1), 8221885 (1)

    Search CenterWatch for drugs/clinical trials and news about KATNB1 / KTNB1 

    Transcripts
    for KATNB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KATNB1 gene: 
    NM_005886.2  

    Unigene Cluster for KATNB1:

    Katanin p80 (WD repeat containing) subunit B 1
    Hs.275675  [show with all ESTs]
    Unigene Representative Sequence: AB209250
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379661(uc002eml.1) ENST00000562592 ENST00000566726 ENST00000566611
    ENST00000566785 ENST00000569627 ENST00000563127 ENST00000563462 ENST00000569018
    ENST00000562542

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KATNB1 (see all 14):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmid: KATNB1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KATNB1
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    Clone
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    Additional cDNA sequence: 

    AB209250.1 AF052432.1 BC001353.2 BT007022.1 CR456762.1 

    13 DOTS entries:

    DT.317141  DT.100821299  DT.101958653  DT.75154833  DT.97852893  DT.100821290  DT.100821294  DT.92440274 
    DT.100821297  DT.100821289  DT.100821293  DT.100821303  DT.92440270 

    24/328 AceView cDNA sequences (see all 328):

    BF063531 BF112101 T31196 BQ438102 BM555835 BM805797 AA699435 BU609069 
    AI139441 BF063559 BU069169 BF952348 AW137639 BM717227 AI801847 BE260378 
    BM559428 BE744782 BM552903 AA338752 AI285217 AW411322 BU625079 BM554090 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KATNB1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                                                                                    -                 -                     
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -                     


    ECgene alternative splicing isoforms for KATNB1

    Expression
    for KATNB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KATNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCTCTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KATNB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KATNB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KATNB1

    SOURCE GeneReport for Unigene cluster: Hs.275675
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    In Situ
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    Orthologs
    for KATNB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KATNB1 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KATNB11 katanin p80 (WD repeat containing) subunit B 1 73.71(n)
    78.71(a)    		   415631  NM_001030559.1  NP_001025730.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KATNB16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343773.1(61764-76137)
    African clawed frog
    (Xenopus laevis)    		 Amphibia katnb1-prov2 katanin p80 (WD40-containing) subunit B 1 74.26(n)    BC043772.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.242042 Danio rerio mRNA similar to katanin p80 (WD40-containing) more 74.92(n)    BC047819.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kat801 , 3 microtubule-based process microtubule
    binding3
    katanin 801    		 36(a)3
    47.96(n)1
    37.93(a)1    		   14B33
    325811  NM_078639.21  NP_523363.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G083906
    AT5G234306
    (see all 4)    		 Katanin p80 WD40 repeat-containing subunit B1-1
    (see all 4)    		 26(a)
    26(a)
    (see all 4)    		 1 ↔ many
    1 ↔ many
    (see all 4)    		 5(2701013-2707273)
    5(7893671-7900387)
    rice
    (Oryza sativa)    		 Liliopsida Os10g04948001 hypothetical protein 49.09(n)
    42.83(a)    		   4348995  NM_001071481.1  NP_001064946.1 


    ENSEMBL Gene Tree for KATNB1 (if available)
    TreeFam Gene Tree for KATNB1 (if available) 

    Paralogs
    for KATNB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KATNB1 gene
    POC1B2  WDR832  WDR52  ATG16L12  WDR882  SNRNP402  WDR5B2  PAFAH1B12  
    PRPF42  DAW12  WDR382  ATG16L22  POC1A2  WDSUB12  
    17 SIMAP similar genes for KATNB1 using alignment to 6 protein entries:     KTNB1_HUMAN (see all proteins):
    POC1B    STRAP    DKFZp762M0115    DKFZp434D199    WDR83    WDR61
    WSB1    MLST8    PF20    GNB5    PAAF1    PLRG1
    WDR82    GNB2L1    THOC3    WDR48    COPB2

    KATNB1 for paralogs           About GeneDecksing



    Genomic Variants
    for KATNB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/512 NCBI SNPs in KATNB1 are shown (see all 512)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1112898451,2
    		--57767676(+) GACTGG/AGGACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs29231491,2
    		C,F,A,H,--57767698(+) ACTGGT/CTGTTA 1 -- us2k1 tfbs326Minor allele frequency- C:0.47NA NS EA WA CSA 2486
    rs1809336371,2
    		--57767718(+) ATTTTC/GTTAGC 1 -- us2k10--------
    rs1872252651,2
    		--57767759(+) AGGGCA/TTTATT 1 -- us2k10--------
    rs1400902231,2
    		--57767773(+) ATTTTC/TTGAAA 1 -- us2k10--------
    rs29657741,2
    		C,F,--57767775(+) TTTTTG/TAAATG 1 -- us2k1 tfbs31Minor allele frequency- T:0.30EA 120
    rs1503771301,2
    		--57767808(+) TGGAGA/TACAGT 1 -- us2k10--------
    rs1132984631,2
    		C,--57767933(+) TTGTA-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1135260251,2
    		C,F,--57767950(+) GACGGG/AGTTTC 1 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs1495140111,2
    		--57768041(+) GGCGTA/GAGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KATNB1 (57769642 - 57791162 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for KATNB1
         2 CNVs: 4958 10504

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    Disorders / Diseases
    for KATNB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KATNB1 for disorders           About GeneDecksing

    OMIM gene information: 602703    OMIM disorders: --

    6 diseases for KATNB1:    About MalaCards
    spastic paraplegia    hereditary spastic paraplegia    paraplegia    spasticity
    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KATNB1:
    Bipolar I disorder

    1 Novoseek disease relationship for KATNB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spastic paraplegia hereditary 74.1 1 18202664 (1)

    Human Genome Epidemiology (HuGE) Navigator: KATNB1 (1 document)

    Export disorders for KATNB1 gene to outside databases

    Publications
    for KATNB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KATNB1 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with KATNB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. (PubMed id 9568719)1, 2, 3, 9 Hartman J.J.... McNally F.J. (1998)
    2. Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. (PubMed id 9658175)1, 2, 9 McNally F.J. and Thomas S. (1998)
    3. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. (PubMed id 10751153)1, 2, 9 McNally K.P.... McNally F.J. (2000)
    4. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PubMed id 16203747)1, 2 Toyo-Oka K.... Hirotsune S. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. (PubMed id 8907702)1, 9 McNally F.J....Vale R.D. (1996)
    7. An essential role for katanin in severing microtubules in the neuron. (PubMed id 10209026)1, 9 Ahmad F.J....Baas P.W. (1999)
    8. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PubMed id 19261606)1, 9 Cummings C.M....Singer J.D. (2009)
    9. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. (PubMed id 15215300)1, 9 Karabay A....Baas P.W. (2004)
    10. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. (PubMed id 18490357)1, 9 Sudo H. and Maru Y. (2008)

    External Searches for KATNB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KATNB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10300 HGNC: 6217 AceView: KATNB1 Ensembl:ENSG00000140854 euGenes: HUgn10300
    ECgene: KATNB1 H-InvDB: KATNB1

    Other Databases showing KATNB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KATNB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KATNB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KATNB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KATNB1 gene:
    Search GeneIP for patents involving KATNB1

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