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KATNB1 Gene

protein-coding   GIFtS: 57
GCID: GC16P057770

Katanin P80 (WD Repeat Containing) Subunit B 1

(Previous name: katanin p80 (WD40-containing) subunit B 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Katanin P80 (WD Repeat Containing) Subunit B 11 2     KAT2
Katanin P80 (WD40-Containing) Subunit B 11 2     Katanin (80 KDa)2
Katanin P80 Subunit B12 3     Katanin P80 WD40 Repeat-Containing Subunit B12
P80 Katanin2 3     Katanin P80 WD40-Containing Subunit B12

External Ids:    HGNC: 62171   Entrez Gene: 103002   Ensembl: ENSG000001408547   OMIM: 6027035   UniProtKB: Q9BVA03   

Export aliases for KATNB1 gene to outside databases

Previous GC identifers: GC16P048165 GC16P057855 GC16P057505 GC16P057546 GC16P056328 GC16P043636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KATNB1 Gene:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to
organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60
subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble
microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family
of ATPases. (provided by RefSeq, Jul 2008)

GeneCards Summary for KATNB1 Gene:
KATNB1 (katanin p80 (WD repeat containing) subunit B 1) is a protein-coding gene. Diseases associated with KATNB1 include hereditary spastic paraplegia, and bipolar i disorder. GO annotations related to this gene include dynein binding and protein heterodimerization activity. An important paralog of this gene is ENSG00000181464.

UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0
Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the
enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote
rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following
nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end
proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule
release within the cell body of neurons may be required for their transport into neuronal processes by
microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)

Gene Wiki entry for KATNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KATNB1 gene promoter:
         Pbx1a   Nkx2-5   LCR-F1   CBF-A   CBF-B   ZID   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKATNB1 promoter sequence
   Search Chromatin IP Primers for KATNB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KATNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q12.2

KATNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KATNB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057770:  view genomic region     (about GC identifiers)

Start:
57,769,642 bp from pter      End:
57,791,162 bp from pter
Size:
21,521 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0 (See protein sequence)
Recommended Name: Katanin p80 WD40 repeat-containing subunit B1  
Size: 655 amino acids; 72334 Da
Subunit: Interacts with PAFAH1B1 (By similarity). Interacts with KATNA1. This interaction enhances the microtubule
binding and severing activity of KATNA1 and also targets this activity to the centrosome. Interacts with dynein,
microtubules and NDEL1
Secondary accessions: A6NCG6 O60620

Explore the universe of human proteins at neXtProt for KATNB1: NX_Q9BVA0

Explore proteomics data for KATNB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96
  • Modification sites at PhosphoSitePlus

  • See KATNB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005877.2  
    ENSEMBL proteins: 
     ENSP00000368982   ENSP00000455350   ENSP00000455270   ENSP00000457347   ENSP00000457046  
     ENSP00000457334  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR026962 Katanin_bsu1
     IPR028021 Katanin_C-terminal
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep

    Graphical View of Domain Structure for InterPro Entry Q9BVA0

    ProtoNet protein and cluster: Q9BVA0

    UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0
    Similarity: Belongs to the WD repeat KATNB1 family
    Similarity: Contains 6 WD repeats


    KATNB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KTNB1_HUMAN, Q9BVA0
    Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the
    enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote
    rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following
    nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end
    proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule
    release within the cell body of neurons may be required for their transport into neuronal processes by
    microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding NAS10751153
    GO:0008568contributes to microtubule-severing ATPase activity IDA10751153
    GO:0045502dynein binding IEA--
    GO:0046982protein heterodimerization activity IPI10751153
         
    KATNB1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for KATNB1:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M 
     Decreased number of cells in m 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Katnb1):
     endocrine/exocrine gland  reproductive system 

    KATNB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KATNB1
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    Selected qRT-PCR Assays for microRNAs that regulate KATNB1 (see all 14):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmidKATNB1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KTNB1_HUMAN, Q9BVA0: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase
    centrosome and mitotic spindle poles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA10751153
    GO:0005737cytoplasm IDA10751153
    GO:0005813centrosome IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane ----

    KATNB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KATNB1
    Interactions:

        Search GeneGlobe Interaction Network for KATNB1

    2 Interacting proteins for KATNB1 (Q9BVA03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1P368973I2D: score=3 
    KATNA1O754493I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA10751153
    GO:0006605protein targeting NAS10751153
    GO:0007026negative regulation of microtubule depolymerization IMP10751153
    GO:0007079mitotic chromosome movement towards spindle pole IEA--
    GO:0010942positive regulation of cell death IEA--

    KATNB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for KATNB1 (KTNB1)

    2 Novoseek inferred chemical compound relationships for KATNB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cellulose 18.9 1 12215512 (1)
    atp 16.4 7 10531065 (2), 15823537 (1), 17178905 (1), 8221885 (1)



    KATNB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KATNB1 gene: 
    NM_005886.2  

    Unigene Cluster for KATNB1:

    Katanin p80 (WD repeat containing) subunit B 1
    Hs.275675  [show with all ESTs]
    Unigene Representative Sequence: AB209250
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379661(uc002eml.1) ENST00000562592 ENST00000566726 ENST00000566611
    ENST00000566785 ENST00000569627 ENST00000563127 ENST00000563462 ENST00000569018
    ENST00000562542
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    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-1285 hsa-miR-340 hsa-miR-612
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    Additional mRNA sequence: 

    AB209250.1 AF052432.1 BC001353.2 BT007022.1 CR456762.1 

    13 DOTS entries:

    DT.317141  DT.100821299  DT.101958653  DT.75154833  DT.97852893  DT.100821290  DT.100821294  DT.92440274 
    DT.100821297  DT.100821289  DT.100821293  DT.100821303  DT.92440270 

    Selected AceView cDNA sequences (see all 328):

    BQ433389 BF063559 AA926933 BM546933 AA913746 BU625079 BQ438102 BE260378 
    AW411322 BX324529 BE302534 AA913254 AW137639 BE296366 BM554090 CD674879 
    AI869839 BU785549 AA996090 AI139441 BU850244 CA488330 T31196 BM559428 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KATNB1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                                                                                    -                 -                     
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -                     


    ECgene alternative splicing isoforms for KATNB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KATNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTCTGCC
    KATNB1 Expression
    About this image


    KATNB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Rib
     
     Testis (Reproductive System)
    KATNB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KATNB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.275675
        Custom PCR Arrays for KATNB1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KATNB1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Katnb11 , 5 katanin p80 (WD40-containing) subunit B 11, 5 89.36(n)1
    95.57(a)1
      8 (47.12 cM)5
    741871  NM_028805.21  NP_083081.21 
     950812015 
    chicken
    (Gallus gallus)
    Aves KATNB11 katanin p80 (WD repeat containing) subunit B 1 73.71(n)
    78.71(a)
      415631  NM_001030559.1  NP_001025730.1 
    lizard
    (Anolis carolinensis)
    Reptilia KATNB16
    katanin p80 (WD repeat containing) subunit B 1
    79(a)
    1 ↔ 1
    GL343773.1(58438-81120)
    African clawed frog
    (Xenopus laevis)
    Amphibia katnb1-prov2 katanin p80 (WD40-containing) subunit B 1 74.26(n)    BC043772.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.242042 Danio rerio mRNA similar to katanin p80 (WD40-containing) more 74.92(n)    BC047819.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kat801 , 3 microtubule-based process microtubule
    binding3
    katanin 801
    36(a)3
    48.14(n)1
    37.98(a)1
      14B33
    325811  NM_078639.21  NP_523363.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP466
    Member of the NineTeen Complex (NTC) that contains...
    17(a)
    1 → many
    XVI(266180-267535) YPL151C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G083901 AT5G08390 49.21(n)
    44.83(a)
      830737  NM_120923.2  NP_568194.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04948001 Os10g0494800 48.85(n)
    42.59(a)
      4348995  NM_001071481.1  NP_001064946.1 


    ENSEMBL Gene Tree for KATNB1 (if available)
    TreeFam Gene Tree for KATNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KATNB1 gene
    ENSG000001814642  CDRT12  PLRG12  FBXW102  
    18 SIMAP similar genes for KATNB1 using alignment to 6 protein entries:     KTNB1_HUMAN (see all proteins):
    POC1B    STRAP    DKFZp762M0115    DKFZp434D199    WDR83    WDR61
    WSB1    MLST8    PF20    GNB5    WDR17    PAAF1
    PLRG1    WDR82    GNB2L1    THOC3    WDR48    COPB2

    KATNB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KATNB1 (see all 683)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112898451,2
    C,F--57767676(+) GACTGG/AGGACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs29231491,2
    C,F,A,H--57767698(+) ACTGGT/CTGTTA 1 -- us2k1 tfbs326Minor allele frequency- C:0.47NA NS EA WA CSA 2486
    rs1809336371,2
    --57767718(+) ATTTTC/GTTAGC 1 -- us2k10--------
    rs1872252651,2
    C--57767759(+) AGGGCA/TTTATT 1 -- us2k10--------
    rs1400902231,2
    C--57767773(+) ATTTTC/TTGAAA 1 -- us2k10--------
    rs29657741,2
    C,F--57767775(+) TTTTTG/TAAATG 1 -- us2k1 tfbs31Minor allele frequency- T:0.30EA 120
    rs1503771301,2
    --57767808(+) TGGAGA/TACAGT 1 -- us2k10--------
    rs1132984631,2
    C--57767933(+) TTGTA-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1135260251,2
    C,F--57767950(+) GACGGG/AGTTTC 1 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs1495140111,2
    --57768041(+) GGCGTA/GAGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KATNB1 (57769642 - 57791162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KATNB1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714544CNV Deletion23290073
    esv1720905CNV Deletion17803354
    nsv509622CNV Insertion20534489
    dgv2873n71CNV Loss21882294
    nsv833246CNV Loss17160897
    nsv528250CNV Loss19592680
    nsv457490CNV Loss19166990
    nsv906729CNV Loss21882294
    nsv817732CNV Loss17921354
    nsv103302CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KATNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for KATNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602703    OMIM disorders: --

    7 diseases for KATNB1:    
    About MalaCards
    hereditary spastic paraplegia    bipolar i disorder    paraplegia    spasticity
    malaria    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for KATNB1:
    Bipolar I disorder

    KATNB1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for KATNB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spastic paraplegia hereditary 74.1 1 18202664 (1)

    Genetic Association Database (GAD): KATNB1
    Human Genome Epidemiology (HuGE) Navigator: KATNB1 (1 document)

    Export disorders for KATNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KATNB1 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with KATNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. (PubMed id 9568719)1, 2, 3, 9 Hartman J.J.... McNally F.J. (Cell 1998)
    2. Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. (PubMed id 9658175)1, 2, 9 McNally F.J. and Thomas S. (Mol. Biol. Cell 1998)
    3. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. (PubMed id 10751153)1, 2, 9 McNally K.P.... McNally F.J. (J. Cell Sci. 2000)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    5. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PubMed id 16203747)1, 2 Toyo-Oka K.... Hirotsune S. (Hum. Mol. Genet. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. (PubMed id 8907702)1, 9 McNally F.J....Vale R.D. (J. Cell. Sci. 1996)
    8. An essential role for katanin in severing microtubules in the neuron. (PubMed id 10209026)1, 9 Ahmad F.J....Baas P.W. (J. Cell Biol. 1999)
    9. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PubMed id 19261606)1, 9 Cummings C.M.... Singer J.D. (J. Biol. Chem. 2009)
    10. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. (PubMed id 15215300)1, 9 Karabay A....Baas P.W. (J. Neurosci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10300 HGNC: 6217 AceView: KATNB1 Ensembl:ENSG00000140854 euGenes: HUgn10300
    ECgene: KATNB1 H-InvDB: KATNB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KATNB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KATNB1 gene:
    Search GeneIP for patents involving KATNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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