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Aliases &
Descriptions
for KATNB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| | | Descriptions |
|---|
| Katanin p80 subunit B1 3 | | katanin (80 kDa) 2 | | katanin p80 (WD repeat containing) subunit B 1 2 | | katanin p80 (WD40-containing) subunit B 1 1, 2 | | katanin p80 subunit B 1 2 | | p80 katanin 3 |
|
| |
Search outside databases for aliases for KATNB1 genePrevious GC identifers: GC16P048165 GC16P057855 GC16P057505 GC16P057546 |
Summaries
for KATNB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KATNB1:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing
cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that
consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1).
The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the
enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq]
UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act
to target the enzymatic subunit of this complex to sites of action such as the centrosome.
Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the
release of microtubules from the centrosome following nucleation. Microtubule release from the
mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle
pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release
within the cell body of neurons may be required for their transport into neuronal processes by
microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)Gene Wiki entry for KATNB1 |
Genomic Location
for KATNB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the KATNB1 gene 
Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q12.2KATNB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P056328:
(about GC identifiers)
Start:
|
56,327,161 bp from pter |
End:
|
56,348,663 bp from pter |
Size:
|
21,503 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins
for KATNB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0 (See
protein sequence)Recommended Name: Katanin p80 WD40-containing subunit B1 Size: 655 amino acids; 72334 Da
Subunit: Interacts with PAFAH1B1 (By similarity). Interacts with KATNA1. This interaction enhances
the microtubule binding and severing activity of KATNA1 and also targets this activity to the
centrosome. Interacts with dynein, microtubules and NDEL1
Subcellular location: Cytoplasm. Centrosome. Spindle. Cytoplasm, cytoskeleton. Note=Predominantly
cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles
Secondary accessions: A6NCG6 O60620Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005877.2
ENSEMBL proteins: ENSP00000268509 ENSP00000377860 ENSP00000368982
Human Recombinant Proteins  OriGene Purified Recombinant Human Protein: KATNB1
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for KATNB1:
Assays for KATNB1: | Protein
Domains/
Families
for KATNB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BVA0
ProtoNet protein and cluster: Q9BVA0 UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0Similarity: Belongs to the WD repeat KATNB1 familySimilarity: Contains 6 WD repeats | Gene Function
for KATNB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005886
 Applied Biosystems Silencer® siRNAs for KATNB1
 Sigma-Aldrich siRNA and siRNA Panels for KATNB1
Sigma-Aldrich shRNA Panels and shRNA for KATNB1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005886
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005886
untagged cDNA clone in CMV expression vector: NM_005886
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005886
UniProtKB/Swiss-Prot: KTNB1_HUMAN, Q9BVA0Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act
to target the enzymatic subunit of this complex to sites of action such as the centrosome.
Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the
release of microtubules from the centrosome following nucleation. Microtubule release from the
mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle
pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release
within the cell body of neurons may be required for their transport into neuronal processes by
microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity)4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for KATNB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for KATNB1 (ENSP000003689823) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds
for KATNB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KATNB1
2  Novoseek chemical compound relationships for KATNB1 gene
About this table
2 PharmGKB drug compound relationships for KATNB1 geneAbout this table
|
Transcripts
for KATNB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005886
Sigma-Aldrich siRNA and siRNA Panels for KATNB1
Sigma-Aldrich shRNA Panels and shRNA for KATNB1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005886 REFSEQ mRNAs for KATNB1 gene: NM_005886.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005886
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005886
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005886
untagged cDNA clone in CMV expression vector: NM_005886
Additional cDNA sequence: AB209250.1 AF052432.1 BC001353.2 BT007022.1 CR456762.1 13 DOTS entries: DT.317141 DT.100821299 DT.101958653 DT.75154833 DT.100821290 DT.97852893 DT.100821294 DT.92440274 DT.100821297 DT.100821289 DT.100821293 DT.100821303 DT.92440270 24/328 AceView cDNA sequences (see all 328
):BM546933 AI346162 AI285217 BX394243 BQ438102 BI829199 BX331270 BQ433389 AA913746 BE250604 AW137639 BX324529 BM554090 BE260378 BU609069 BX342992 BX324530 BX363074 AA913254 AA629224 AA338752 AW104381 AW249923 AI869839
 highest scoring ESTs for KATNB1:AF052432 AA227553 AA227562 AA233249 AA236220 AA251403 AA338752 AA457696 AA480641 AA494368 Unigene Cluster for KATNB1: Katanin p80 (WD repeat containing) subunit B 1 Hs.275675 [show with all ESTs]Unigene Representative Sequence: AB209250
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KATNB1 (see all 6
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KATNB1
3 Ensembl transcripts including schematic representations: ENST00000268509
ENST00000394326
ENST00000379661
|
Expression
for KATNB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KATNB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KATNB1
1 / 2 / 3 6 probe-sets matching KATNB1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGCCTCTGCC
SOURCE GeneReport for Unigene cluster: Hs.275675
Expression variation in blood from EXPOLDB for KATNB1 |
Orthologs
for KATNB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KATNB1 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for KATNB1
ENSEMBL Gene Tree for KATNB1 | Paralogs
for KATNB1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KATNB1 gene
- WDR612 PRPF192 WDR882 WDR382
|
SNPs/Variants
for KATNB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KATNB1 (up to first 250kb)
|
Disorders & Mutations
for KATNB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602703
1 Novoseek disease relationship for KATNB1 gene
About this table
1 PharmGKB disease relationship for KATNB1 geneAbout this table
|
Medical News
for KATNB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KATNB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/52 PubMed articles for KATNB1 gene (see all 52
):- Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. (PubMed id 9568719)1, 2, 3, 4 Hartman J.J.... McNally F.J. (1998)
- Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. (PubMed id 9658175)1, 3, 4 McNally F.J. and Thomas S. (1998)
- Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. (PubMed id 10751153)1, 3, 4 McNally K.P.... McNally F.J. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PubMed id 16203747)3, 4 Toyo-Oka K.... Hirotsune S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. (PubMed id 8907702)1, 3 McNally F.J....Vale R.D. (1996)
- An essential role for katanin in severing microtubules in the neuron. (PubMed id 10209026)1, 3 Ahmad F.J....Baas P.W. (1999)
- Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. (PubMed id 15215300)1, 3 Karabay A....Baas P.W. (2004)
- LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. (PubMed id 18490357)1, 3 Sudo H. and Maru Y. (2008)
|
Search for KATNB1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KATNB1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KATNB1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KATNB1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for KATNB1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for KATNB1:
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