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Aliases for KATNAL2 Gene

Aliases for KATNAL2 Gene

  • Katanin Catalytic Subunit A1 Like 2 2 3 5
  • Katanin P60 Subunit A-Like 2 2 4
  • EC 3.6.4.3 4 61
  • Katanin Catalytic Subunit A Like 2 2
  • Katanin P60 Subunit A Like 2 2
  • P60 Katanin-Like 2 4

External Ids for KATNAL2 Gene

Previous GeneCards Identifiers for KATNAL2 Gene

  • GC18P042781
  • GC18U900248
  • GC18P044526
  • GC18P041427

Summaries for KATNAL2 Gene

GeneCards Summary for KATNAL2 Gene

KATNAL2 (Katanin Catalytic Subunit A1 Like 2) is a Protein Coding gene. Diseases associated with KATNAL2 include Tinea Capitis and Dermatophytosis. GO annotations related to this gene include microtubule binding and microtubule-severing ATPase activity. An important paralog of this gene is KATNA1.

UniProtKB/Swiss-Prot for KATNAL2 Gene

  • Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KATNAL2 Gene

Genomics for KATNAL2 Gene

Regulatory Elements for KATNAL2 Gene

Enhancers for KATNAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G046916 1 ENCODE 13.9 +0.1 84 2.6 ATF1 ARNT SIN3A YY1 GLIS2 ZNF143 ZNF207 ZMIZ1 SP5 ZHX2 KATNAL2 HDHD2 LOC105372097 PIAS2
GH18G046939 0.7 ENCODE 13.4 +22.6 22558 2.1 MXI1 PKNOX1 JUN ZFP37 SIN3A CEBPB EP300 NR2F2 JUND GATA2 KATNAL2 ELOA3 ELOA2 IER3IP1 HDHD2 GC18P046926 ELOA3D
GH18G047174 1.1 ENCODE 5.6 +258.3 258333 2.4 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 ZNF207 HDHD2 IER3IP1 KATNAL2 ENSG00000267228
GH18G047184 0.9 ENCODE 6.8 +267.4 267422 0.5 HDAC1 CBX3 RB1 CHAMP1 ZNF766 ZNF366 ELK1 GATA2 CBX5 SIRT6 HDHD2 IER3IP1 KATNAL2 GC18M047235 RNU6-1131P
GH18G047149 1.1 ENCODE 5.5 +233.1 233080 2.5 PKNOX1 FOXA2 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 HDHD2 IER3IP1 KATNAL2 ENSG00000267228
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KATNAL2 on UCSC Golden Path with GeneCards custom track

Promoters for KATNAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102935 -292 2401 ARNT SIN3A GLIS2 ZNF143 ZNF207 ZMIZ1 SP5 ZHX2 REST SMARCA4

Genomic Location for KATNAL2 Gene

Chromosome:
18
Start:
46,917,492 bp from pter
End:
47,102,243 bp from pter
Size:
184,752 bases
Orientation:
Plus strand

Genomic View for KATNAL2 Gene

Genes around KATNAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KATNAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KATNAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KATNAL2 Gene

Proteins for KATNAL2 Gene

  • Protein details for KATNAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT4-KATL2_HUMAN
    Recommended name:
    Katanin p60 ATPase-containing subunit A-like 2
    Protein Accession:
    Q8IYT4

    Protein attributes for KATNAL2 Gene

    Size:
    538 amino acids
    Molecular mass:
    61253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BI560635; Type=Frameshift; Positions=183, 188, 200, 203; Evidence={ECO:0000305};

    Alternative splice isoforms for KATNAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KATNAL2 Gene

Selected DME Specific Peptides for KATNAL2 Gene

Q8IYT4:
  • SKWRGDSEK
  • RRLEKRI
  • LAKAVATEC

Post-translational modifications for KATNAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for KATNAL2 Gene

Gene Families for KATNAL2 Gene

Protein Domains for KATNAL2 Gene

Suggested Antigen Peptide Sequences for KATNAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYT4

UniProtKB/Swiss-Prot:

KATL2_HUMAN :
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
Family:
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
genes like me logo Genes that share domains with KATNAL2: view

Function for KATNAL2 Gene

Molecular function for KATNAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.

Enzyme Numbers (IUBMB) for KATNAL2 Gene

Gene Ontology (GO) - Molecular Function for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25910212
GO:0005524 ATP binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KATNAL2: view
genes like me logo Genes that share phenotypes with KATNAL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KATNAL2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KATNAL2 Gene

Localization for KATNAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KATNAL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KATNAL2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KATNAL2: view

Pathways & Interactions for KATNAL2 Gene

SuperPathways for KATNAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031122 cytoplasmic microtubule organization IBA --
genes like me logo Genes that share ontologies with KATNAL2: view

No data available for Pathways by source and SIGNOR curated interactions for KATNAL2 Gene

Drugs & Compounds for KATNAL2 Gene

(3) Drugs for KATNAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for KATNAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with KATNAL2: view

Transcripts for KATNAL2 Gene

mRNA/cDNA for KATNAL2 Gene

(14) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KATNAL2 Gene

Katanin p60 subunit A-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KATNAL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2:
SP3: -
SP4:

Relevant External Links for KATNAL2 Gene

GeneLoc Exon Structure for
KATNAL2
ECgene alternative splicing isoforms for
KATNAL2

Expression for KATNAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KATNAL2 Gene

Protein differential expression in normal tissues from HIPED for KATNAL2 Gene

This gene is overexpressed in Bone marrow stromal cell (13.0) and Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KATNAL2 Gene



Protein tissue co-expression partners for KATNAL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KATNAL2 Gene:

KATNAL2

SOURCE GeneReport for Unigene cluster for KATNAL2 Gene:

Hs.404137

Evidence on tissue expression from TISSUES for KATNAL2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with KATNAL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KATNAL2 Gene

Orthologs for KATNAL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KATNAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KATNAL2 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia KATNAL2 34 35
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia KATNAL2 34 35
  • 87.98 (n)
rat
(Rattus norvegicus)
Mammalia Katnal2 34
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Katnal2 34 16 35
  • 84.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KATNAL2 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KATNAL2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves KATNAL2 34 35
  • 73.74 (n)
lizard
(Anolis carolinensis)
Reptilia KATNAL2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia katnal2 34
  • 69.76 (n)
zebrafish
(Danio rerio)
Actinopterygii katnal2 34 35
  • 65.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10793 34 35
  • 51.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004012 34
  • 47.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS4 35
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34560 34
  • 56 (n)
rice
(Oryza sativa)
Liliopsida Os01g0673500 34
  • 60.69 (n)
Species where no ortholog for KATNAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KATNAL2 Gene

ENSEMBL:
Gene Tree for KATNAL2 (if available)
TreeFam:
Gene Tree for KATNAL2 (if available)

Paralogs for KATNAL2 Gene

Paralogs for KATNAL2 Gene

genes like me logo Genes that share paralogs with KATNAL2: view

Variants for KATNAL2 Gene

Sequence variations from dbSNP and Humsavar for KATNAL2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs193920804 Uncertain significance 47,034,898(-) GCCCA(C/T)CTCAC intron-variant, reference, missense
rs1000002092 -- 46,928,442(+) CTCTG(A/G)AAGTT intron-variant
rs1000030999 -- 46,946,259(+) TTTCC(A/G)CGTCT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000068562 -- 46,932,275(+) GCCAA(A/C)CATAA intron-variant
rs1000124933 -- 46,952,394(+) GTATG(C/G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KATNAL2 Gene

Variant ID Type Subtype PubMed ID
dgv3346n100 CNV loss 25217958
esv2659165 CNV deletion 23128226
esv2717039 CNV deletion 23290073
esv3574009 CNV gain 25503493
esv3583037 CNV loss 25503493
esv3583040 CNV loss 25503493
esv3642446 CNV gain 21293372
esv3642447 CNV gain 21293372
esv3642448 CNV loss 21293372
esv3642450 CNV loss 21293372
esv3642451 CNV gain 21293372
esv3642452 CNV gain 21293372
esv998188 CNV gain 20482838
nsv1056744 CNV gain 25217958
nsv1057235 CNV loss 25217958
nsv1067278 CNV gain 25217958
nsv1138621 CNV deletion 24896259
nsv1149591 CNV duplication 26484159
nsv167 CNV insertion 15895083
nsv2280 CNV insertion 18451855
nsv2281 CNV insertion 18451855
nsv2284 CNV insertion 18451855
nsv471406 CNV gain 19718026
nsv509693 CNV insertion 20534489
nsv576813 CNV loss 21841781
nsv576815 CNV gain 21841781
nsv576818 CNV loss 21841781
nsv576819 CNV loss 21841781
nsv828225 CNV gain 20364138
nsv833639 CNV loss 17160897
nsv833640 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for KATNAL2 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KATNAL2 Gene

Human Gene Mutation Database (HGMD)
KATNAL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KATNAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KATNAL2 Gene

Disorders for KATNAL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KATNAL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tinea capitis
  • dermatophytosis of scalp
dermatophytosis
  • tinea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KATNAL2

Genetic Association Database (GAD)
KATNAL2
Human Genome Epidemiology (HuGE) Navigator
KATNAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KATNAL2
genes like me logo Genes that share disorders with KATNAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KATNAL2 Gene

Publications for KATNAL2 Gene

  1. Meta-analysis of genome-wide association studies for personality. (PMID: 21173776) de Moor M.H. … Boomsma D.I. (Mol. Psychiatry 2012) 3 46 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  4. Patterns and rates of exonic de novo mutations in autism spectrum disorders. (PMID: 22495311) Neale B.M. … Daly M.J. (Nature 2012) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for KATNAL2 Gene

Sources for KATNAL2 Gene

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