KATNAL2 Gene
protein-coding GIFtS: 49
GCID: GC18P044526
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|
katanin p60 subunit A-like 2
| |
Aliases
for KATNAL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Katanin P60 Subunit A-Like 21 2 3 | | P60 Katanin-Like 22 3 | | EC 3.6.4.33 8 | | DKFZP667C1651 | | MGC332111 | | Katanin P60 ATPase-Containing Subunit A-Like 22 |
Export aliases for KATNAL2 gene to outside databasesPrevious GC identifers: GC18P042781 GC18U900248 GC18P041427 |
Summaries
for KATNAL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4Function: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization ofcellular microtubule arrays (By similarity)
|
Genomic Views
for KATNAL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KATNAL2 gene promoter:
AP-1 ATF-2 c-Jun c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KATNAL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNAL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1KATNAL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P044526: view genomic region
(about GC identifiers)
Start:
|
44,497,455 bp from pter |
End:
|
44,628,614 bp from pter |
Size:
|
131,160 bases |
Orientation:
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plus strand |
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Proteins
for KATNAL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4 (See
protein sequence)Recommended Name: Katanin p60 ATPase-containing subunit A-like 2 Size: 538 amino acids; 61253 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=BI560635; Type=Frameshift; Positions=183, 188, 200, 203;Alternative splicing: 2 isoforms: Q8IYT4-1 Q8IYT4-2 Explore the universe of human proteins at neXtProt for KATNAL2: NX_Q8IYT4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYT4
3 DME Specific Peptides for KATNAL2 (Q8IYT4)
KATNAL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112593.2
ENSEMBL proteins: ENSP00000467610 ENSP00000466674 ENSP00000245121 ENSP00000348478 ENSP00000464779 ENSP00000466302 ENSP00000467488
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KATNAL2 for ontologies About GeneDecksing
KATNAL2 Antibody Products:
Assay Products for KATNAL2: |
Protein
Domains /
Families
for KATNAL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KATNAL2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYT4ProtoNet protein and cluster: Q8IYT4 UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4Similarity: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamilySimilarity: Contains 1 LisH domain |
Function
for KATNAL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4Function: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization ofcellular microtubule arrays (By similarity)Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.31 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KATNAL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0008568 | microtubule-severing ATPase activity |
IEA | -- |
KATNAL2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KATNAL2:
|
Pathways & Interactions
for KATNAL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KATNAL2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for KATNAL2 (Q8IYT43 ENSP000002451214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KATNAL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KATNAL2
Search CenterWatch for drugs/clinical trials and news about KATNAL2 / KATL2
|
Transcripts
for KATNAL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KATNAL2 gene: NM_031303.2 Unigene Cluster for KATNAL2: Katanin p60 subunit A-like 2 Hs.404137 [show with all ESTs]Unigene Representative Sequence: NM_0313038 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592005 ENST00000585469 ENST00000245121(uc010dnq.1 uc002lco.3)
ENST00000356157 ENST00000585383 ENST00000588433 ENST00000586198 ENST00000591522
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KATNAL2 (NM_031303) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KATNAL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL2 |
Additional cDNA sequence: AK309134.1 AL512748.1 BC034999.2 6 DOTS entries: DT.207998 DT.100730586 DT.121083830 DT.95149773 DT.107111 DT.95119220
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KATNAL2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KATNAL2
|
Expression
for KATNAL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KATNAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGCCCGTGA
About this image
See KATNAL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KATNAL2
SOURCE GeneReport for Unigene cluster: Hs.404137
SABiosciences Custom PCR Arrays for KATNAL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KATNAL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KATNAL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KATNAL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KATNAL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL2 |
Orthologs
for KATNAL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KATNAL2 gene from 6/23 species (see all 23) About this table
ENSEMBL Gene Tree for KATNAL2 (if available)
TreeFam Gene Tree for KATNAL2 (if available) |
Paralogs
for KATNAL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KATNAL2 gene
- VPS4B2 ENSG000002609142 KATNAL12 VPS4A2 KATNA12
13 SIMAP similar genes for KATNAL2 using alignment to 6 protein entries: KATL2_HUMAN (see all proteins):DKFZp667C165 PSMC1 DKFZp434E0418 KATNA1 VPS4A VPS4B
KATNAL1 PSMC5 VCP PSMC6 ATAD2B PSMC2
ATAD1
KATNAL2 for paralogs About GeneDecksing
|
Genomic Variants
for KATNAL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KATNAL2 (44497455 - 44628614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 31 variations for KATNAL2
15/31 CNVs (see all 31): 35561 35557 35555 35547 35562 35566 35549 35548 35565 35552 35554 5055 35564 73139 35560
Human Gene Mutation Database (HGMD): KATNAL2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KATNAL2 |
|
Disorders
/ Diseases
for KATNAL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KATNAL2 for disorders About GeneDecksing
OMIM gene information: 614697
OMIM disorders: --
1  disease for KATNAL2: About MalaCardstinea capitis
1 disease from the University of Copenhagen DISEASES database for KATNAL2:Tinea capitis Human Genome Epidemiology (HuGE) Navigator: KATNAL2 (1 document)
Export disorders for KATNAL2 gene to outside databases
|
Publications
for KATNAL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KATNAL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KATNAL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Patterns and rates of exonic de novo mutations in auti sm spectrum disorders. (PubMed id 22495311)1 Neale B.M....Daly M.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Meta-analysis of genome-wide association studies for personality. (PubMed id 21173776)1 de Moor M.H....Boomsma D.I. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for KATNAL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KATNAL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KATNAL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KATNAL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KATNAL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KATNAL2 gene:
Search GeneIP for patents involving KATNAL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KATNAL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KATNAL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KATNAL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNAL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KATNAL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KATNAL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KATNAL2 |
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 | | | KATNAL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL2 |
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