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Aliases for KATNAL2 Gene

Aliases for KATNAL2 Gene

  • Katanin P60 Subunit A-Like 2 2 3 4
  • EC 4 63
  • P60 Katanin-Like 2 4

External Ids for KATNAL2 Gene

Previous GeneCards Identifiers for KATNAL2 Gene

  • GC18P042781
  • GC18U900248
  • GC18P044526
  • GC18P041427

Summaries for KATNAL2 Gene

GeneCards Summary for KATNAL2 Gene

KATNAL2 (Katanin P60 Subunit A-Like 2) is a Protein Coding gene. Diseases associated with KATNAL2 include tinea capitis. GO annotations related to this gene include microtubule binding and microtubule-severing ATPase activity. An important paralog of this gene is KATNA1.

UniProtKB/Swiss-Prot for KATNAL2 Gene

  • Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KATNAL2 Gene

Genomics for KATNAL2 Gene

Regulatory Elements for KATNAL2 Gene

Genomic Location for KATNAL2 Gene

46,917,492 bp from pter
47,102,243 bp from pter
184,752 bases
Plus strand

Genomic View for KATNAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KATNAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KATNAL2 Gene

Proteins for KATNAL2 Gene

  • Protein details for KATNAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Katanin p60 ATPase-containing subunit A-like 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KATNAL2 Gene

    538 amino acids
    Molecular mass:
    61253 Da
    Quaternary structure:
    No Data Available
    • Sequence=BI560635; Type=Frameshift; Positions=183, 188, 200, 203; Evidence={ECO:0000305};

    Alternative splice isoforms for KATNAL2 Gene


neXtProt entry for KATNAL2 Gene

Proteomics data for KATNAL2 Gene at MOPED

Selected DME Specific Peptides for KATNAL2 Gene

Post-translational modifications for KATNAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KATNAL2 Gene

Antibody Products

Domains for KATNAL2 Gene

Gene Families for KATNAL2 Gene

  • AATP :ATPases / AAA-type

Protein Domains for KATNAL2 Gene

Suggested Antigen Peptide Sequences for KATNAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IYT4
  • Contains 1 LisH domain.
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
genes like me logo Genes that share domains with KATNAL2: view

Function for KATNAL2 Gene

Molecular function for KATNAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.

Enzyme Numbers (IUBMB) for KATNAL2 Gene

Gene Ontology (GO) - Molecular Function for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with KATNAL2: view

Phenotypes for KATNAL2 Gene

genes like me logo Genes that share phenotypes with KATNAL2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KATNAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KATNAL2 Gene

Localization for KATNAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KATNAL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KATNAL2 Gene COMPARTMENTS Subcellular localization image for KATNAL2 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KATNAL2: view

Pathways for KATNAL2 Gene

SuperPathways for KATNAL2 Gene

No Data Available

Interacting Proteins for KATNAL2 Gene

Gene Ontology (GO) - Biological Process for KATNAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
GO:0008152 metabolic process IEA --
GO:0031122 cytoplasmic microtubule organization IBA --
genes like me logo Genes that share ontologies with KATNAL2: view

No data available for Pathways by source for KATNAL2 Gene

Transcripts for KATNAL2 Gene

mRNA/cDNA for KATNAL2 Gene

(3) Additional mRNA sequences :
(10) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KATNAL2 Gene

Katanin p60 subunit A-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KATNAL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KATNAL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP3: -

Relevant External Links for KATNAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KATNAL2 Gene

mRNA expression in normal human tissues for KATNAL2 Gene

Protein differential expression in normal tissues for KATNAL2 Gene

This gene is overexpressed in Bone marrow stromal cell (13.0) and Lymph node (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KATNAL2 Gene

SOURCE GeneReport for Unigene cluster for KATNAL2 Gene Hs.404137

genes like me logo Genes that share expressions with KATNAL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KATNAL2 Gene

Orthologs for KATNAL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KATNAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KATNAL2 35
  • 87.98 (n)
  • 87.77 (a)
  • 77 (a)
(Canis familiaris)
Mammalia KATNAL2 35
  • 89.27 (n)
  • 89.06 (a)
  • 78 (a)
(Mus musculus)
Mammalia Katnal2 35
  • 84.28 (n)
  • 86.57 (a)
Katnal2 16
Katnal2 36
  • 71 (a)
(Pan troglodytes)
Mammalia KATNAL2 35
  • 99.28 (n)
  • 99.14 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Katnal2 35
  • 84.52 (n)
  • 86.88 (a)
(Monodelphis domestica)
Mammalia KATNAL2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia KATNAL2 36
  • 70 (a)
(Gallus gallus)
Aves KATNAL2 35
  • 73.74 (n)
  • 75.54 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia KATNAL2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia katnal2 35
  • 69.76 (n)
  • 74.35 (a)
(Danio rerio)
Actinopterygii katnal2 35
  • 65.39 (n)
  • 72.68 (a)
katnal2 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004012 35
  • 47.33 (n)
  • 39.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10793 35
  • 51.5 (n)
  • 45.49 (a)
CG10793 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS4 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34560 35
  • 56 (n)
  • 58.67 (a)
(Oryza sativa)
Liliopsida Os01g0673500 35
  • 60.69 (n)
  • 62.13 (a)
Species with no ortholog for KATNAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KATNAL2 Gene

Gene Tree for KATNAL2 (if available)
Gene Tree for KATNAL2 (if available)

Paralogs for KATNAL2 Gene

Paralogs for KATNAL2 Gene

genes like me logo Genes that share paralogs with KATNAL2: view

Variants for KATNAL2 Gene

Sequence variations from dbSNP and Humsavar for KATNAL2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs20449 -- 47,089,642(+) CCCAG(A/C)CACAT intron-variant
rs998818 -- 47,037,791(+) TATTA(C/T)TTTAA intron-variant
rs998819 -- 47,037,810(+) CACCA(C/T)AAGTA intron-variant
rs1369069 -- 47,078,085(-) AATGT(A/G)TGTGA intron-variant
rs1465722 -- 47,038,128(-) GGCAG(C/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KATNAL2 Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv833639 CNV Loss 17160897
nsv909609 CNV Loss 21882294
nsv509693 CNV Insertion 20534489
esv2659165 CNV Deletion 23128226
nsv821062 CNV Duplication 20802225
esv29643 CNV Gain+Loss 19812545
esv2717038 CNV Deletion 23290073
nsv2280 CNV Insertion 18451855
nsv2281 CNV Insertion 18451855
nsv514871 CNV Complex 21397061
nsv2282 CNV Loss 18451855
nsv2283 CNV Insertion 18451855
dgv3416n71 CNV Gain 21882294
nsv167 CNV Insertion 15895083
nsv2284 CNV Insertion 18451855
esv2717039 CNV Deletion 23290073
nsv833640 CNV Loss 17160897
nsv471406 CNV Duplication 19718026
nsv828225 CNV Gain 20364138
esv998188 CNV Gain 20482838
nsv909612 CNV Gain 21882294

Relevant External Links for KATNAL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KATNAL2 Gene

Disorders for KATNAL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KATNAL2 Gene in MalaCards »

(1) Diseases for KATNAL2 Gene including...

(1) University of Copenhagen DISEASES for KATNAL2 Gene

Relevant External Links for KATNAL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KATNAL2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for KATNAL2 Gene

Publications for KATNAL2 Gene

  1. Meta-analysis of genome-wide association studies for personality. (PMID: 21173776) de Moor M.H. … Boomsma D.I. (Mol. Psychiatry 2012) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for KATNAL2 Gene

Sources for KATNAL2 Gene

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