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KATNAL2 Gene

protein-coding GIFtS: 44

GC18P042781

katanin p60 subunit A-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZP667C165 ^¹
DKFZp667C165 ^²
EC 3.6.4.3 ^³
MGC33211 ^¹, ²

Descriptions
katanin p60 ATPase-containing subunit A-like 2 ^²
katanin p60 subunit A-like 2 ^², ³
p60 katanin-like 2 ^², ³

External Ids
HGNC: 25387¹
Entrez Gene: 83473²
UniProtKB: Q8IYT4³
Ensembl: ENSG00000167216⁷

Search outside databases for aliases for KATNAL2 gene

Previous GC identifer: GC18U900248

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4

Function: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid

reorganization of cellular microtubule arrays (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KATNAL2 gene

Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1

KATNAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P042781: (about GC identifiers)

Start:	42,780,785 bp from pter
End:	42,881,661 bp from pter
Size:	100,877 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010966.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4 (See protein sequence)

Recommended Name: Katanin p60 ATPase-containing subunit A-like 2

Size: 538 amino acids; 61253 Da

Alternative splicing: 2 isoforms: Q8IYT4-1 Q8IYT4-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_112593.2

ENSEMBL proteins:

ENSP00000348478 ENSP00000245121

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KATNAL2)
	Human Recombinant Proteins from Abnova (KATNAL2)

OriGene Purified Recombinant Human Protein: KATNAL2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005874	microtubule	IEA	--

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Antibodies for KATNAL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KATNAL2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KATNAL2)
	Novus Biologicals Antibodies for KATNAL2

Assays for KATNAL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IYT4

ProtoNet protein and cluster: Q8IYT4

UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4

Similarity: Belongs to the AAA ATPase family

Similarity: Contains 1 LisH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KATNAL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031303

Applied Biosystems Silencer® siRNAs for KATNAL2

Sigma-Aldrich siRNA for KATNAL2

Sigma-Aldrich shRNA for KATNAL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KATNAL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_031303
Myc/DDK tagged cDNA clone in CMV expression vector: NM_031303
untagged cDNA clones in CMV expression vector (see all 2): BC034999

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_031303

UniProtKB/Swiss-Prot: KATL2_HUMAN, Q8IYT4

Function: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid

reorganization of cellular microtubule arrays (By similarity)

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Number (IUBMB): EC 3.6.4.3

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008568	microtubule-severing ATPase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0017111	nucleoside-triphosphatase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KATNAL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KATNAL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031303

Sigma-Aldrich siRNA for KATNAL2

Sigma-Aldrich shRNA for KATNAL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_031303

REFSEQ mRNAs for KATNAL2 gene:

NM_031303.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_031303

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031303
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_031303
                                 untagged cDNA clones in CMV expression vector (see all 2): BC034999

Additional cDNA sequence:

AK309134.1 AL512748.1 BC034999.2 CR593634.1

6 DOTS entries:

DT.207998 DT.100730586 DT.107111 DT.121083830 DT.95149773 DT.95119220

highest scoring ESTs for KATNAL2:

AA743793 AA769938 AI041087 AL569377 AW901557 AW901559 BC034999 BE701879 BE701886 BE701889

Unigene Cluster for KATNAL2:

Katanin p60 subunit A-like 2

Hs.404137 [show with all ESTs]

Unigene Representative Sequence: NM_031303

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KATNAL2

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:					-		-
SP2:
SP3:					-
SP4:

About this scheme

ECgene alternative splicing isoforms for KATNAL2

2 Ensembl transcripts including schematic representations:

ENST00000356157 ENST00000245121

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KATNAL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KATNAL2

¹ / ² / ³

3 probe-sets matching KATNAL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60192_at²^{, 3}	U95-C	1	0.88	1.00	0.65	1.17	W80485	0.60	1.00	0.82	1
42041_at²^{, 3}	U95-B	1	0.88	1.00	0.96	0.87	AA743793	0.60	1.00	0.82	1
1554234_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.404137

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KATNAL2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KATNAL2¹	--	katanin p60 subunit A-like 2	86.55(n) 84.82(a)	490465 XM_547587.2 XP_547587.2
chimpanzee (Pan troglodytes)	KATNAL2¹	--	katanin p60 subunit A-like 2	99.21(n) 98.93(a)	455404 XM_001148241.1 XP_001148241.1
cow (Bos taurus)	KATNAL2¹	--	katanin p60 subunit A-like 2	88.05(n) 87.98(a)	514354 XM_592188.3 XP_592188.2
rat (Rattus norvegicus)	Katnal2¹	--	katanin p60 subunit A-like 2	84.52(n) 86.67(a)	307253 XM_225707.4 XP_225707.4
mouse (Mus musculus)	Katnal2^{1, 5}	18⁵	katanin p60 subunit A-like 2^{1, 5}	84.43(n)¹ 86.53(a)¹	71206¹ NM_027721.2¹ NP_081997.1¹ AC132608⁵ AI429686⁵ (see all 10)

About this table Species with no ortholog for KATNAL2

ENSEMBL Gene Tree for KATNAL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KATNAL2 gene

KATNAL1² KATNA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/467 NCBI SNPs in KATNAL2 are shown (see all 467 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7233515^1,2	A,C,F,H	42839953(+)	`GGAAAG/ATGCCA`	1	S/N	mis¹		8		EU EA WA	838
	rs9304340^1,2	A,C,F,H	42780580(+)	`GCCCTA/GTGCTC`	1	--	ng5¹		4		EU EA WA	418
	rs2187092^1,2	A,C,F,H	42780796(+)	`TGACTA/CCTTTT`	1	--	ut5¹ ese³		4		EU EA WA	412
--	rs9304339^1,2	A,C	42778847(+)	`cgtgcA/Cactgc`	1	--	ng5¹		0	--	--	--	--
	rs11875527^1,2	C	42779280(+)	`GCTTCA/GCCTAG`	1	--	ng5¹		0	--	--	--	--
	rs2289130^1,2	F,H	42880628(+)	`GAGACT/GGAGGG`	1	T/T	syn¹ ese³		5		EA EU WA	1724
	rs2571020^1,2	A,C,F,H,O	42838187(-)	`AACAGA/TAGGAA`	1	--	int¹		12		EA NA EU WA	1052
	rs2571031^1,2	A,C,F,H,O	42831061(+)	`AGGTAT/CTTTTA`	1	--	int¹		7		EU EA WA NA	558
	rs2571021^1,2	A,C,F,H,O	42837496(-)	`GCACAA/GCTATT`	1	--	int¹		11		EU EA WA NA	976
	rs2571011^1,2	A,C,F,H,O	42850897(+)	`AGGTCC/GCAGTG`	1	--	int¹		14		EU EA WA NA	1234

About this table

HapMap Linkage Disequilibrium images for KATNAL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for KATNAL2 gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)⁴ Nusbaum C.... Lander E.S. (2005)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)³ Brandenberger R.... Stanton L.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83473	HGNC: 25387	Ensembl:ENSG00000167216	euGenes: HUgn83473	ECgene: KATNAL2
H-InvDB: KATNAL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KATNAL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KATNAL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KATNAL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KATNAL2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KATNAL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KATNAL2)
	Antibodies (KATNAL2)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (KATNAL2)
	Antibodies (KATNAL2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for KATNAL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KATNAL2

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KATNAL2 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for KATNAL2

Summaries
for KATNAL2

Genomic Location
for KATNAL2

Proteins
for KATNAL2

Protein Domains/
Families
for KATNAL2

Gene Function
for KATNAL2

Pathways & Interactions
for KATNAL2

Drugs & Compounds
for KATNAL2

Transcripts
for KATNAL2

Expression
for KATNAL2

Orthologs
for KATNAL2

Paralogs
for KATNAL2

SNPs/Variants
for KATNAL2

Disorders & Mutations
for KATNAL2

Medical News
for KATNAL2

Publications
for KATNAL2

Search for KATNAL2

Genome Databases showing KATNAL2

Other Databases showing KATNAL2

Specialized Databases showing KATNAL2

Licensable Technologies
for KATNAL2

Services
for KATNAL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KATNAL2 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor KATNAL2

Summariesfor KATNAL2

Genomic Locationfor KATNAL2

Proteinsfor KATNAL2

Protein Domains/Familiesfor KATNAL2

Gene Functionfor KATNAL2

Pathways & Interactionsfor KATNAL2

Drugs & Compoundsfor KATNAL2

Transcriptsfor KATNAL2

Expression for KATNAL2

Orthologsfor KATNAL2

Paralogsfor KATNAL2

SNPs/Variantsfor KATNAL2

Disorders & Mutationsfor KATNAL2

Medical Newsfor KATNAL2

Publicationsfor KATNAL2

Search for KATNAL2

Genome Databases showing KATNAL2

Other Databases showing KATNAL2

Specialized Databases showing KATNAL2

Licensable Technologiesfor KATNAL2

Servicesfor KATNAL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KATNAL2

Summaries
for KATNAL2

Genomic Location
for KATNAL2

Proteins
for KATNAL2

Protein Domains/
Families
for KATNAL2

Gene Function
for KATNAL2

Pathways & Interactions
for KATNAL2

Drugs & Compounds
for KATNAL2

Transcripts
for KATNAL2

Expression
for KATNAL2

Orthologs
for KATNAL2

Paralogs
for KATNAL2

SNPs/Variants
for KATNAL2

Disorders & Mutations
for KATNAL2

Medical News
for KATNAL2

Publications
for KATNAL2

Licensable Technologies
for KATNAL2

Services
for KATNAL2