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Aliases for KATNAL1 Gene

Aliases for KATNAL1 Gene

  • Katanin P60 Subunit A-Like 1 2 3 4
  • EC 3.6.4.3 4 63
  • P60 Katanin-Like 1 4

External Ids for KATNAL1 Gene

Previous GeneCards Identifiers for KATNAL1 Gene

  • GC13M028581
  • GC13M029680
  • GC13M030776
  • GC13M011590

Summaries for KATNAL1 Gene

GeneCards Summary for KATNAL1 Gene

KATNAL1 (Katanin P60 Subunit A-Like 1) is a Protein Coding gene. GO annotations related to this gene include microtubule-severing ATPase activity. An important paralog of this gene is KATNA1.

UniProtKB/Swiss-Prot for KATNAL1 Gene

  • Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KATNAL1 Gene

Genomics for KATNAL1 Gene

Regulatory Elements for KATNAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KATNAL1 Gene

Start:
30,202,630 bp from pter
End:
30,307,487 bp from pter
Size:
104,858 bases
Orientation:
Minus strand

Genomic View for KATNAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KATNAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KATNAL1 Gene

Proteins for KATNAL1 Gene

  • Protein details for KATNAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW62-KATL1_HUMAN
    Recommended name:
    Katanin p60 ATPase-containing subunit A-like 1
    Protein Accession:
    Q9BW62
    Secondary Accessions:
    • A8K5X4

    Protein attributes for KATNAL1 Gene

    Size:
    490 amino acids
    Molecular mass:
    55392 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KATNAL1 Gene

Proteomics data for KATNAL1 Gene at MOPED

Post-translational modifications for KATNAL1 Gene

  • Ubiquitination at Lys280
  • Modification sites at PhosphoSitePlus

Other Protein References for KATNAL1 Gene

Antibody Products

Domains for KATNAL1 Gene

Gene Families for KATNAL1 Gene

HGNC:
  • AATP :ATPases / AAA-type

Suggested Antigen Peptide Sequences for KATNAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW62

UniProtKB/Swiss-Prot:

KATL1_HUMAN :
  • Q9BW62
Family:
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
genes like me logo Genes that share domains with KATNAL1: view

Function for KATNAL1 Gene

Molecular function for KATNAL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity).

Enzyme Numbers (IUBMB) for KATNAL1 Gene

Gene Ontology (GO) - Molecular Function for KATNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with KATNAL1: view

Phenotypes for KATNAL1 Gene

genes like me logo Genes that share phenotypes with KATNAL1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KATNAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for KATNAL1 Gene

Localization for KATNAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KATNAL1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KATNAL1 Gene COMPARTMENTS Subcellular localization image for KATNAL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KATNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with KATNAL1: view

Pathways for KATNAL1 Gene

SuperPathways for KATNAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KATNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
GO:0007283 spermatogenesis IEA --
GO:0008152 metabolic process IEA --
GO:0031122 cytoplasmic microtubule organization IBA --
genes like me logo Genes that share ontologies with KATNAL1: view

No data available for Pathways by source for KATNAL1 Gene

Compounds for KATNAL1 Gene

(4) HMDB Compounds for KATNAL1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with KATNAL1: view

Transcripts for KATNAL1 Gene

Unigene Clusters for KATNAL1 Gene

Katanin p60 subunit A-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KATNAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KATNAL1 Gene

No ASD Table

Relevant External Links for KATNAL1 Gene

GeneLoc Exon Structure for
KATNAL1
ECgene alternative splicing isoforms for
KATNAL1

Expression for KATNAL1 Gene

mRNA expression in normal human tissues for KATNAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KATNAL1 Gene

This gene is overexpressed in Fetal Brain (18.1), Neutrophil (11.8), Monocytes (11.3), Testis (8.8), Frontal cortex (6.4), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KATNAL1 Gene

SOURCE GeneReport for Unigene cluster for KATNAL1 Gene Hs.243596

mRNA Expression by UniProt/SwissProt for KATNAL1 Gene

Q9BW62-KATL1_HUMAN
Tissue specificity: Expressed in testis, restricted to Sertoli cells (at protein level).
genes like me logo Genes that share expressions with KATNAL1: view

Expression partners for KATNAL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KATNAL1 Gene

Orthologs for KATNAL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KATNAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KATNAL1 35
  • 90.54 (n)
  • 97.14 (a)
KATNAL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KATNAL1 35
  • 94.76 (n)
  • 97.96 (a)
KATNAL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Katnal1 35
  • 85.66 (n)
  • 94.67 (a)
Katnal1 16
Katnal1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KATNAL1 35
  • 99.86 (n)
  • 99.8 (a)
KATNAL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Katnal1 35
  • 84.56 (n)
  • 95.49 (a)
oppossum
(Monodelphis domestica)
Mammalia KATNAL1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KATNAL1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KATNAL1 35
  • 81.66 (n)
  • 90.39 (a)
KATNAL1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KATNAL1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia katnal1 35
  • 77.48 (n)
  • 86.86 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18550 35
katnal1 35
  • 70.64 (n)
  • 81.11 (a)
si:dkey-185p13.1 36
  • 18 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001783 35
  • 58.73 (n)
  • 65.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kat60 35
  • 55.69 (n)
  • 58.96 (a)
kat-60L1 36
  • 34 (a)
ManyToMany
Kat60 36
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mei-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS4 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KATNAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KATNAL1 Gene

ENSEMBL:
Gene Tree for KATNAL1 (if available)
TreeFam:
Gene Tree for KATNAL1 (if available)

Paralogs for KATNAL1 Gene

Paralogs for KATNAL1 Gene

Selected SIMAP similar genes for KATNAL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KATNAL1: view

Variants for KATNAL1 Gene

Sequence variations from dbSNP and Humsavar for KATNAL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs10478 -- 30,203,065(-) ATACA(A/G)ACTAA utr-variant-3-prime
rs169264 -- 30,264,651(+) agaaa(C/T)gcaaa intron-variant
rs169331 -- 30,304,558(+) ccact(G/T)cgccc intron-variant
rs169332 -- 30,226,156(+) atttg(A/C)attct intron-variant
rs183236 -- 30,291,917(+) gtaat(C/G)ccagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KATNAL1 Gene

Variant ID Type Subtype PubMed ID
nsv832572 CNV Gain 17160897
esv2657382 CNV Deletion 23128226
nsv528192 CNV Loss 19592680
nsv521987 CNV Loss 19592680
nsv899962 CNV Loss 21882294

Relevant External Links for KATNAL1 Gene

HapMap Linkage Disequilibrium report
KATNAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KATNAL1 Gene

Disorders for KATNAL1 Gene

Relevant External Links for KATNAL1

Genetic Association Database (GAD)
KATNAL1
Human Genome Epidemiology (HuGE) Navigator
KATNAL1

No disorders were found for KATNAL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KATNAL1 Gene

Publications for KATNAL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ab initio protein modelling reveals novel human MIT domains. (PMID: 19302785) Rigden D.J. … Clague M.J. (FEBS Lett. 2009) 2 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for KATNAL1 Gene

Sources for KATNAL1 Gene

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