KATNAL1 Gene
protein-coding GIFtS: 52
GCID: GC13M030776
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katanin p60 subunit A-like 1
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Aliases
for KATNAL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Katanin P60 Subunit A-Like 11 2 3 | | P60 Katanin-Like 12 3 | | EC 3.6.4.33 8 | | MGC25991 | | Katanin P60 ATPase-Containing Subunit A-Like 12 |
Export aliases for KATNAL1 gene to outside databasesPrevious GC identifers: GC13M028581 GC13M029680 GC13M011590 |
Summaries
for KATNAL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KATL1_HUMAN, Q9BW62Function: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and malefertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubulearrays (By similarity)
|
Genomic Views
for KATNAL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KATNAL1 gene promoter:
AREB6 PPAR-gamma1 POU2F1 SEF-1 (1) PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KATNAL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNAL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.3 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12.3KATNAL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M030776: view genomic region
(about GC identifiers)
Start:
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30,776,767 bp from pter |
End:
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30,881,621 bp from pter |
Size:
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104,855 bases |
Orientation:
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minus strand |
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Proteins
for KATNAL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KATL1_HUMAN, Q9BW62 (See
protein sequence)Recommended Name: Katanin p60 ATPase-containing subunit A-like 1 Size: 490 amino acids; 55392 Da
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: A8K5X4Explore the universe of human proteins at neXtProt for KATNAL1: NX_Q9BW62
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BW62
4/20 DME Specific Peptides for KATNAL1 (Q9BW62) (see all 20)
KATNAL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001014402.1 NP_115492.1
ENSEMBL proteins: ENSP00000369989 ENSP00000369991 ENSP00000397776 ENSP00000407792
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KATNAL1 for ontologies About GeneDecksing
KATNAL1 Antibody Products:
Assay Products for KATNAL1: |
Protein
Domains /
Families
for KATNAL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KATNAL1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BW62ProtoNet protein and cluster: Q9BW62 1 Blocks protein family: IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: KATL1_HUMAN, Q9BW62Similarity: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily |
Function
for KATNAL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KATL1_HUMAN, Q9BW62Function: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and malefertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubulearrays (By similarity)Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.31 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KATNAL1 (NM_032116) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KATNAL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0008568 | microtubule-severing ATPase activity |
IEA | -- |
KATNAL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KATNAL1:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Katnal1):
KATNAL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KATNAL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KATNAL1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for KATNAL1 (Q9BW622, 3 ENSP000003699894) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KATNAL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KATNAL1
4 HMDB Compounds for KATNAL1 About this table
Search CenterWatch for drugs/clinical trials and news about KATNAL1 / KATL1
|
Transcripts
for KATNAL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KATNAL1 gene (2 alternative transcripts): NM_001014380.2 NM_032116.4 Unigene Cluster for KATNAL1: Katanin p60 subunit A-like 1 Hs.243596 [show with all ESTs]Unigene Representative Sequence: NM_0321165 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380615(uc001uss.3 uc001ust.3) ENST00000380617 ENST00000480854
ENST00000414289 ENST00000441394
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KATNAL1 (NM_032116) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KATNAL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL1 |
Additional cDNA sequence: AK097423.1 AK291439.1 AK315724.1 BC000612.2 BX647147.1 3 DOTS entries: DT.40129064 DT.97798511 DT.95157638 22 AceView cDNA sequences: NM_032116 BC000612 BU634530 AK097423 AI809648 AI039250 AL704125 BE311939 BQ772434 BG913072 BU568394 BX954382 BI462044 AL702104 AI379588 BU568862 BM152637 CD694916 AA910028 AA284402 CA419634 AA292530
GeneLoc Exon Structure
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Expression
for KATNAL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KATNAL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATGATGGC
About this image
See KATNAL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KATNAL1
SOURCE GeneReport for Unigene cluster: Hs.243596
UniProtKB/Swiss-Prot: KATL1_HUMAN, Q9BW62Tissue specificity: Expressed in testis, restricted to Sertoli cells (at protein level)
SABiosciences Custom PCR Arrays for KATNAL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KATNAL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KATNAL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KATNAL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KATNAL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL1 |
Orthologs
for KATNAL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KATNAL1 gene from 6/27 species (see all 27) About this table
ENSEMBL Gene Tree for KATNAL1 (if available)
TreeFam Gene Tree for KATNAL1 (if available) |
Paralogs
for KATNAL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KATNAL1 gene
- VPS4B2 ENSG000002609142 VPS4A2 KATNA12 KATNAL22
8 SIMAP similar genes for KATNAL1 using alignment to 3 protein entries: KATL1_HUMAN (see all proteins):KATNA1 VPS4A VPS4B KATNAL2 PSMC6 FIGNL1
PSMC5 SPAST
KATNAL1 for paralogs About GeneDecksing
|
Genomic Variants
for KATNAL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KATNAL1 (30776767 - 30881621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KATNAL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KATNAL1 |
|
Disorders
/ Diseases
for KATNAL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KATNAL1 for disorders About GeneDecksing
OMIM gene information: 614764
OMIM disorders: --
1  disease for KATNAL1: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: KATNAL1 (1 document)
Export disorders for KATNAL1 gene to outside databases
|
Publications
for KATNAL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KATNAL1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KATNAL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
- KATNAL1 regulation of Sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility. (PubMed id 22654668)2 Smith L.B.... Peters J. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- KL1 is a novel microtubule severing enzyme that regula tes mitotic spindle architecture. (PubMed id 20519956)1 Sonbuchner T.M....Sharp D.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for KATNAL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KATNAL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KATNAL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KATNAL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KATNAL1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KATNAL1 gene:
Search GeneIP for patents involving KATNAL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KATNAL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KATNAL1 | | OriGene shRNA RFP for KATNAL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KATNAL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KATNAL1 | | | OriGene Protein Over-expression Lysate for KATNAL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KATNAL1 | | OriGene 3'-UTR Clone for KATNAL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KATNAL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KATNAL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KATNAL1 | | OriGene Custom Protein Services for KATNAL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KATNAL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KATNAL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KATNAL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KATNAL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KATNAL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KATNAL1 |
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 | | | KATNAL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KATNAL1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KATNAL1 |
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