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Aliases for KATNA1 Gene

Aliases for KATNA1 Gene

  • Katanin Catalytic Subunit A1 2 3 5
  • EC 3.6.4.3 4 61
  • Katanin P60 (ATPase-Containing) Subunit A 1 2
  • Katanin P60 (ATPase Containing) Subunit A 1 2
  • Katanin P60 Subunit A1 4
  • P60 Katanin 4

External Ids for KATNA1 Gene

Previous GeneCards Identifiers for KATNA1 Gene

  • GC06M149429
  • GC06M149763
  • GC06M9O0076
  • GC06M149957
  • GC06M147482

Summaries for KATNA1 Gene

Entrez Gene Summary for KATNA1 Gene

  • Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

GeneCards Summary for KATNA1 Gene

KATNA1 (Katanin Catalytic Subunit A1) is a Protein Coding gene. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development. GO annotations related to this gene include protein heterodimerization activity and microtubule binding. An important paralog of this gene is KATNAL1.

UniProtKB/Swiss-Prot for KATNA1 Gene

  • Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Gene Wiki entry for KATNA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KATNA1 Gene

Genomics for KATNA1 Gene

Regulatory Elements for KATNA1 Gene

Enhancers for KATNA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G150266 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.1 -621.4 -621352 8.3 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF416 LATS1 NUP43 PPIL4 KATNA1 ENSG00000231760 RNU4-7P ENSG00000238594 ENSG00000233330 PPP1R14C RAET1G
GH06G150142 1.5 Ensembl ENCODE dbSUPER 20.3 -495.3 -495322 4.6 PKNOX1 ARNT CREB3L1 AGO1 FEZF1 ZNF2 ZNF548 ZNF263 SP3 ZNF592 NUP43 LATS1 PPIL4 KATNA1 ENSG00000231760 PPP1R14C ENSG00000238594
GH06G150195 1.2 ENCODE dbSUPER 20.3 -547.7 -547710 1.6 PKNOX1 ARNT FEZF1 ZNF2 FOS ZNF548 ZNF263 TSHZ1 ZNF488 ZNF662 NUP43 LATS1 PPIL4 KATNA1 ENSG00000231760 ENSG00000238594 RNU4-7P RAET1E PPP1R14C LOC105378054
GH06G149894 1.3 Ensembl ENCODE dbSUPER 18.6 -247.6 -247598 3.6 ELF3 TBP FOXA2 ZSCAN4 RAD21 ZEB1 GTF3C2 RCOR1 ZNF548 FOS NUP43 LATS1 ENSG00000216906 KATNA1 RAET1E PPIL4 ENSG00000231760 LRP11 LOC105378051
GH06G150250 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -605.4 -605391 8.0 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF766 FOS ZNF263 SP3 JUNB NUP43 PPIL4 ENSG00000231760 KATNA1 LATS1 ENSG00000238594 PPP1R14C RAET1G ULBP2 RAET1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KATNA1 on UCSC Golden Path with GeneCards custom track

Promoters for KATNA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205048 1018 2401 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for KATNA1 Gene

Chromosome:
6
Start:
149,594,873 bp from pter
End:
149,649,018 bp from pter
Size:
54,146 bases
Orientation:
Minus strand

Genomic View for KATNA1 Gene

Genes around KATNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KATNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KATNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KATNA1 Gene

Proteins for KATNA1 Gene

  • Protein details for KATNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75449-KTNA1_HUMAN
    Recommended name:
    Katanin p60 ATPase-containing subunit A1
    Protein Accession:
    O75449
    Secondary Accessions:
    • E1P5A3
    • Q5TFA8
    • Q5TFA9
    • Q86VN2
    • Q9NU52

    Protein attributes for KATNA1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55965 Da
    Quaternary structure:
    • Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules (By similarity). Interacts with KATNB1, which may serve as a targeting subunit. Interacts with dynein and NDEL1 (By similarity). Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42.

    Alternative splice isoforms for KATNA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KATNA1 Gene

Selected DME Specific Peptides for KATNA1 Gene

O75449:
  • TTFFNVSS
  • DIADLVEAKKLL
  • KSVSAAD
  • EAVVLPMWMP
  • TNVCRDAS
  • GIRRPWKGVLM
  • KHVKDIM
  • PGPRKRQS
  • MAMRRRI
  • NKYLYSVKDT
  • WDDIADL
  • LAKAVATEC
  • RRLEKRI
  • QMDGVGG
  • REYALLGNY
  • KLAREYAL
  • CSRRGTS
  • EHEASRRVK

Post-translational modifications for KATNA1 Gene

  • Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
  • Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
  • Ubiquitination at posLast=7171
  • Modification sites at PhosphoSitePlus

Domains & Families for KATNA1 Gene

Gene Families for KATNA1 Gene

Suggested Antigen Peptide Sequences for KATNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75449

UniProtKB/Swiss-Prot:

KTNA1_HUMAN :
  • The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Domain:
  • The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
Family:
  • Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
genes like me logo Genes that share domains with KATNA1: view

Function for KATNA1 Gene

Molecular function for KATNA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Enzyme Numbers (IUBMB) for KATNA1 Gene

Gene Ontology (GO) - Molecular Function for KATNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19261606
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IDA 10751153
GO:0008568 contributes_to microtubule-severing ATPase activity IEA,IDA 10751153
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KATNA1: view
genes like me logo Genes that share phenotypes with KATNA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KATNA1

miRNA for KATNA1 Gene

miRTarBase miRNAs that target KATNA1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KATNA1 Gene

Localization for KATNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KATNA1 Gene

Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KATNA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for KATNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA,IDA 10751153
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA,IEA 19261606
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IDA 19261606
genes like me logo Genes that share ontologies with KATNA1: view

Pathways & Interactions for KATNA1 Gene

genes like me logo Genes that share pathways with KATNA1: view

Pathways by source for KATNA1 Gene

Gene Ontology (GO) - Biological Process for KATNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051013 microtubule severing IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with KATNA1: view

No data available for SIGNOR curated interactions for KATNA1 Gene

Drugs & Compounds for KATNA1 Gene

(3) Drugs for KATNA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for KATNA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with KATNA1: view

Transcripts for KATNA1 Gene

Unigene Clusters for KATNA1 Gene

Katanin p60 (ATPase containing) subunit A 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KATNA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for KATNA1 Gene

GeneLoc Exon Structure for
KATNA1
ECgene alternative splicing isoforms for
KATNA1

Expression for KATNA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KATNA1 Gene

Protein differential expression in normal tissues from HIPED for KATNA1 Gene

This gene is overexpressed in Pancreatic juice (20.3), Peripheral blood mononuclear cells (17.3), and Testis (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KATNA1 Gene



Protein tissue co-expression partners for KATNA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KATNA1 Gene:

KATNA1

SOURCE GeneReport for Unigene cluster for KATNA1 Gene:

Hs.450175

Evidence on tissue expression from TISSUES for KATNA1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KATNA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KATNA1 Gene

Orthologs for KATNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KATNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KATNA1 34 35
  • 99.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KATNA1 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KATNA1 34 35
  • 93.14 (n)
dog
(Canis familiaris)
Mammalia KATNA1 34 35
  • 92.8 (n)
rat
(Rattus norvegicus)
Mammalia Katna1 34
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Katna1 34 16 35
  • 88.59 (n)
chicken
(Gallus gallus)
Aves KATNA1 34 35
  • 82.52 (n)
lizard
(Anolis carolinensis)
Reptilia KATNA1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia katna1 34
  • 76.92 (n)
Str.19881 34
zebrafish
(Danio rerio)
Actinopterygii katna1 34 35
  • 70.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta katanin-60 36
  • 68 (a)
CG1193 36
  • 57 (a)
Kat60 35
  • 47 (a)
ManyToMany
kat-60L1 35
  • 34 (a)
ManyToMany
BG:DS06874.3 36
  • 33 (a)
CG10793 36
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea mei-1 36 35
  • 45 (a)
K04D7.2a 36
  • 35 (a)
K04D7.2b 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS4 35
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ERH3 34
  • 56.11 (n)
rice
(Oryza sativa)
Liliopsida Os01g0683100 34
  • 55.49 (n)
Os.26940 34
wheat
(Triticum aestivum)
Liliopsida Ta.3044 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8489 34
Species where no ortholog for KATNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KATNA1 Gene

ENSEMBL:
Gene Tree for KATNA1 (if available)
TreeFam:
Gene Tree for KATNA1 (if available)

Paralogs for KATNA1 Gene

Paralogs for KATNA1 Gene

genes like me logo Genes that share paralogs with KATNA1: view

Variants for KATNA1 Gene

Sequence variations from dbSNP and Humsavar for KATNA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000002191 -- 149,623,881(+) ATCAA(A/C)GATGA intron-variant
rs1000012406 -- 149,630,900(+) AACAC(A/T)ATATA intron-variant
rs1000174553 -- 149,618,321(+) AAAAA(C/T)AGAAA intron-variant
rs1000246908 -- 149,636,823(+) TTTTA(A/G)TAGAG intron-variant
rs1000263815 -- 149,618,605(+) AACCA(A/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KATNA1 Gene

Variant ID Type Subtype PubMed ID
esv2676732 CNV deletion 23128226
esv3611210 CNV loss 21293372
nsv949868 CNV duplication 24416366

Variation tolerance for KATNA1 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KATNA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KATNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KATNA1 Gene

Disorders for KATNA1 Gene

Relevant External Links for KATNA1

Genetic Association Database (GAD)
KATNA1
Human Genome Epidemiology (HuGE) Navigator
KATNA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KATNA1

No disorders were found for KATNA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KATNA1 Gene

Publications for KATNA1 Gene

  1. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PMID: 19287380) Maddika S. … Chen J. (Nat. Cell Biol. 2009) 3 4 22 64
  2. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. (PMID: 10751153) McNally K.P. … McNally F.J. (J. Cell Sci. 2000) 3 4 22 64
  3. Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. (PMID: 9658175) McNally F.J. … Thomas S. (Mol. Biol. Cell 1998) 2 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PMID: 19261606) Cummings C.M. … Singer J.D. (J. Biol. Chem. 2009) 3 4 64

Products for KATNA1 Gene

Sources for KATNA1 Gene

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