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KAT8 Gene

protein-coding   GIFtS: 54
GCID: GC16P031130

K(Lysine) Acetyltransferase 8

(Previous name: MYST histone acetyltransferase 1)
(Previous symbol: MYST1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
K(Lysine) Acetyltransferase 81 2     MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 12 3
MYST11 2 3 5     ZC2HC82
MOF2 3 5     Histone Acetyltransferase KAT82
MYST Histone Acetyltransferase 11 2     Histone Acetyltransferase MYST12
Lysine Acetyltransferase 82 3     Ortholog Of Drosophila Males Absent On The First (MOF)2
MYST-12 3     Probable Histone Acetyltransferase MYST12
hMOF2 3     EC 2.3.1.483

External Ids:    HGNC: 179331   Entrez Gene: 841482   Ensembl: ENSG000001035107   OMIM: 6099125   UniProtKB: Q9H7Z63   

Export aliases for KAT8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KAT8 Gene:
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic
MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a
C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Feb 2012)

GeneCards Summary for KAT8 Gene:
KAT8 (K(lysine) acetyltransferase 8) is a protein-coding gene. GO annotations related to this gene include histone acetyltransferase activity and transcription factor binding. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot: KAT8_HUMAN, Q9H7Z6
Function: Histone acetyltransferase which may be involved in transcriptional activation. May influence the
function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing
specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on
several lysine residues. That activity is less specific than the one of the MSL complex

Gene Wiki entry for KAT8 (MYST1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KAT8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKAT8 promoter sequence
   Search Chromatin IP Primers for KAT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KAT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.1

KAT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031130:  view genomic region     (about GC identifiers)

Start:
31,127,075 bp from pter      End:
31,142,714 bp from pter
Size:
15,640 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KAT8_HUMAN, Q9H7Z6 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT8  
Size: 458 amino acids; 52403 Da
Subunit: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8,
MSL1/hampin, MSL2L1 and MSL3L1. Interacts with MSL1; the interaction is direct. Component of the NSL complex at
least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with
KANSL1; the interaction is direct. Component of some MLL1/MLL complex, at least composed of the core components
KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C,
KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1,
TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through
the chromodomain. Interacts with KANSL1; the interaction is direct
Sequence caution: Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAL56648.1; Type=Frameshift; Positions=23, 26, 52;
Selected PDB 3D structures from and Proteopedia for KAT8 (see all 7):
2GIV (3D)        2PQ8 (3D)        2Y0M (3D)        3QAH (3D)        3TOA (3D)        3TOB (3D)    
Secondary accessions: A8K4Z1 G5E9P2 Q659G0 Q7LC17 Q8IY59 Q8WYB4 Q8WZ14 Q9HAC5 Q9NR35
Alternative splicing: 2 isoforms:  Q9H7Z6-1   Q9H7Z6-2   (Ref.4 (AAH37773) sequence is in conflict in position: 454:I->M)

Explore the universe of human proteins at neXtProt for KAT8: NX_Q9H7Z6

Explore proteomics data for KAT8 at MOPED

Post-translational modifications: 

  • Autoacetylation at Lys-274 is required for proper function1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KAT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115564.2  NP_892003.2  

    ENSEMBL proteins: 
     ENSP00000456933   ENSP00000406037   ENSP00000454592   ENSP00000219797  
    Reactome Protein details: Q9H7Z6

    KAT8 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for KAT8 (5 products) 

     
    antibodies-online peptides for KAT8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002717 MOZ_SAS
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q9H7Z6

    ProtoNet protein and cluster: Q9H7Z6

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB002717 MOZ/SAS-like protein


    UniProtKB/Swiss-Prot: KAT8_HUMAN, Q9H7Z6
    Similarity: Belongs to the MYST (SAS/MOZ) family
    Similarity: Contains 1 C2HC-type zinc finger
    Similarity: Contains 1 chromo domain


    Find genes that share domains with KAT8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT8_HUMAN, Q9H7Z6
    Function: Histone acetyltransferase which may be involved in transcriptional activation. May influence the
    function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing
    specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on
    several lysine residues. That activity is less specific than the one of the MSL complex
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004402histone acetyltransferase activity IDA11742995
    GO:0005515protein binding IPI11965546
    GO:0008134transcription factor binding IDA11742995
    GO:0016407acetyltransferase activity IDA11742995
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with KAT8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KAT8:
     Lamellipodia cells 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kat8):
     cellular  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     no phenotypic analysis 

    Find genes that share phenotypes with KAT8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KAT8: Kat8tm1.1Avo Kat8tm2Thl

       genOway: Develop your customized and physiologically relevant rodent model for KAT8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAT8_HUMAN, Q9H7Z6: Nucleus. Chromosome (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0000776kinetochore IEA--
    GO:0005634nucleus IDA11742995
    GO:0005654nucleoplasm TAS--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with KAT8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KAT8 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Packaging Of Telomere Ends
    Histone modification0.31
    3p53 pathway
    p53 pathway


    Find genes that share SuperPaths with KAT8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KAT8
        p53 pathway


    1 Reactome Pathway for KAT8
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT8: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KAT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KAT8 (Q9H7Z61, 2, 3 ENSP000004060374) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4FP628053, ENSP000003669744I2D: score=2 STRING: ENSP00000366974
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016573histone acetylation IDA11742995
    GO:0030099myeloid cell differentiation IDA11742995

    Find genes that share ontologies with KAT8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KAT8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KAT8 gene (2 alternative transcripts): 
    NM_032188.2  NM_182958.2  

    Unigene Cluster for KAT8:

    K(lysine) acetyltransferase 8
    Hs.533803  [show with all ESTs]
    Unigene Representative Sequence: AK225660
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543774 ENST00000448516(uc002eax.3) ENST00000539683 ENST00000538768(uc002eaz.3)
    ENST00000537402(uc002eba.3) ENST00000573144 ENST00000219797(uc002eay.3)

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    hsa-miR-491-5p
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      QuantiFast Probe-based Assays in human, mouse, rat KAT8

    Additional mRNA sequence: 

    AF217501.1 AF260665.2 AK021872.1 AK024102.1 AK225660.1 AK291106.1 AL050395.1 BC037773.1 

    9 DOTS entries:

    DT.100815352  DT.455917  DT.100832888  DT.91994715  DT.120688821  DT.86848006  DT.120688827  DT.100025160 
    DT.100815353 

    Selected AceView cDNA sequences (see all 154):

    BF058490 F26568 BQ670743 BQ641237 CA397719 BE540486 AU119306 CB157527 
    AW517427 AW612043 AI217074 BX339367 BP342476 CR625141 BU844462 CR596671 
    CR596643 AI479441 AJ713213 CA944590 BG829369 AI934823 AI524729 BM551831 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -     -                 -     -     -                                                         
    SP2:                                                                                                            
    SP3:              -     -                                                                                       
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for KAT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KAT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATATGAGA
    KAT8 Expression
    About this image


    KAT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    KAT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KAT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533803
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT8: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KAT8 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat81 , 5 MYST histone acetyltransferase 15
    K(lysine) acetyltransferase 81
    88.79(n)1
    98.25(a)1
      7 (69.83 cM)5
    677731  NM_026370.11  NP_080646.11 
     1279125175 
    lizard
    (Anolis carolinensis)
    Reptilia KAT86
    K(lysine) acetyltransferase 8
    82(a)
    1 ↔ 1
    GL343220.1(2316255-2325376)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192732 Xenopus laevis transcribed sequence with moderate similarity more 85.39(n)    48029594 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb22g022 Danio rerio cDNA clone MGC66387 IMAGE5777448, complete more 78.13(n)    BC055629.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mof1 males absent on the first 64.25(n)
    60.47(a)
      31518  NM_078496.2  NP_511051.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mys-21 mys-2 52.62(n)
    48.48(a)
      173281  NM_061066.5  NP_493467.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESA16
    Catalytic subunit of the histone acetyltransferase...
    35(a)
    1 → many
    XV(792531-793868) YOR244W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HAM11 HAM1 57.66(n)
    54.86(a)
      836582  NM_125857.2  NP_201266.1 
    rice
    (Oryza sativa)
    Liliopsida Os.98442 Oryza sativa (japonica cultivar-group) putative histone more 73.74(n)    NM_193033.1 


    ENSEMBL Gene Tree for KAT8 (if available)
    TreeFam Gene Tree for KAT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KAT8 gene
    KAT6B2  KAT52  KAT72  KAT6A2  
    7 SIMAP similar genes for KAT8 using alignment to 2 protein entries:     KAT8_HUMAN (see all proteins):
    KAT5    DKFZp313G1618    KAT7    KAT6A    KAT6B    MYST3
    MYST4

    Find genes that share paralogs with KAT8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KAT8 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864981261,2
    --28688153(+) AGTAGA/GTGGGA 2 -- us2k10--------
    rs1486503731,2
    --31127001(+) GCCCCA/GAGGCC 2 -- us2k10--------
    rs352722341,2
    C--31127014(-) AAAAA-/ATTAGC 2 -- us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1412052831,2
    --31127181(+) GTTCAA/GTCTCC 2 -- us2k10--------
    rs20525811,2
    C,H--31127222(-) CCATAT/CACAAT 2 -- us2k113Minor allele frequency- C:0.00NA WA CSA EA 376
    rs1415735921,2
    --31130705(+) ACCTCA/GTGATT 2 -- int10--------
    rs1898880351,2
    --31130778(+) AATTAC/TACATT 2 -- int10--------
    rs1922245151,2
    --31130903(+) TATTAA/GCTCTT 2 -- int10--------
    rs19784861,2
    C,F,H--31130910(-) AAGTGA/GTAAGA 2 -- int119Minor allele frequency- G:0.04NS NA WA CSA EA 1210
    rs1846470711,2
    --31131070(+) TTCTCC/TTGCCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for KAT8 (31127075 - 31142714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KAT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905743CNV Loss21882294
    nsv905729CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2672n71CNV Loss21882294
    nsv833193CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KAT8
    DNA2.0 Custom Variant and Variant Library Synthesis for KAT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609912    OMIM disorders: --


    Find genes that share disorders with KAT8           About GenesLikeMe

    1 Novoseek inferred disease relationship for KAT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chromosomal aberrations 41.9 3 17967868 (1)


    Export disorders for KAT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KAT8 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with KAT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. (PubMed id 10786633)1, 2, 3 Neal K.C.... Lucchesi J.C. (Biochim. Biophys. Acta 2000)
    2. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2, 9 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    3. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PubMed id 12397079)1, 2, 9 Pardo P.S.... Pereira-Smith O.M. (J. Biol. Chem. 2002)
    4. MYST protein acetyltransferase activity requires active site lysine autoacetylation. (PubMed id 22020126)1, 2 Yuan H....Marmorstein R. (EMBO J. 2012)
    5. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. (PubMed id 21691301)1, 2 Sun B.... Ding J. (Cell Res. 2011)
    6. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PubMed id 21217699)1, 2 Kadlec J....Akhtar A. (amp 2011)
    7. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PubMed id 20018852)1, 2 Cai Y.... Conaway R.C. (J. Biol. Chem. 2010)
    8. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    9. Involvement of human MOF in ATM function. (PubMed id 15923642)1, 2 Gupta A.... Pandita T.K. (Mol. Cell. Biol. 2005)
    10. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84148 HGNC: 17933 AceView: MYST1 Ensembl:ENSG00000103510 euGenes: HUgn84148
    ECgene: KAT8 H-InvDB: KAT8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KAT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KAT8 gene:
    Search GeneIP for patents involving KAT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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