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Aliases for KAT8 Gene

Aliases for KAT8 Gene

  • Lysine Acetyltransferase 8 2 3 4
  • K(Lysine) Acetyltransferase 8 2 3 5
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 1 3 4
  • MYST Histone Acetyltransferase 1 2 3
  • MYST-1 3 4
  • MYST1 3 4
  • HMOF 3 4
  • MOF 3 4
  • Ortholog Of Drosophila Males Absent On The First (MOF) 3
  • Probable Histone Acetyltransferase MYST1 3
  • Histone Acetyltransferase MYST1 3
  • EC 2.3.1.48 4
  • ZC2HC8 3

External Ids for KAT8 Gene

Previous HGNC Symbols for KAT8 Gene

  • MYST1

Previous GeneCards Identifiers for KAT8 Gene

  • GC16P031130

Summaries for KAT8 Gene

Entrez Gene Summary for KAT8 Gene

  • This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for KAT8 Gene

KAT8 (Lysine Acetyltransferase 8) is a Protein Coding gene. Among its related pathways are p53 pathway (Pathway Interaction Database) and Chromatin organization. GO annotations related to this gene include enzyme binding and histone acetyltransferase activity. An important paralog of this gene is KAT7.

UniProtKB/Swiss-Prot for KAT8 Gene

  • Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at Lys-120.

Gene Wiki entry for KAT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT8 Gene

Genomics for KAT8 Gene

Regulatory Elements for KAT8 Gene

Promoters for KAT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KAT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for KAT8 Gene

Chromosome:
16
Start:
31,115,754 bp from pter
End:
31,131,393 bp from pter
Size:
15,640 bases
Orientation:
Plus strand

Genomic View for KAT8 Gene

Genes around KAT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT8 Gene

Proteins for KAT8 Gene

  • Protein details for KAT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z6-KAT8_HUMAN
    Recommended name:
    Histone acetyltransferase KAT8
    Protein Accession:
    Q9H7Z6
    Secondary Accessions:
    • A8K4Z1
    • G5E9P2
    • Q659G0
    • Q7LC17
    • Q8IY59
    • Q8WYB4
    • Q8WZ14
    • Q9HAC5
    • Q9NR35

    Protein attributes for KAT8 Gene

    Size:
    458 amino acids
    Molecular mass:
    52403 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with MSL1; the interaction is direct. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KANSL1; the interaction is direct. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct.
    SequenceCaution:
    • Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAL56648.1; Type=Frameshift; Positions=23, 26, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT8 Gene

    Alternative splice isoforms for KAT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT8 Gene

Proteomics data for KAT8 Gene at MOPED

Post-translational modifications for KAT8 Gene

  • Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KAT8 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT8 (MYST1)

No data available for DME Specific Peptides for KAT8 Gene

Domains & Families for KAT8 Gene

Suggested Antigen Peptide Sequences for KAT8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7Z6

UniProtKB/Swiss-Prot:

KAT8_HUMAN :
  • Contains 1 chromo domain.
  • Belongs to the MYST (SAS/MOZ) family.
  • Contains 1 C2HC-type zinc finger.
Domain:
  • Contains 1 chromo domain.
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with KAT8: view

Function for KAT8 Gene

Molecular function for KAT8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at Lys-120.

Enzyme Numbers (IUBMB) for KAT8 Gene

Gene Ontology (GO) - Molecular Function for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IDA 11742995
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KAT8: view
genes like me logo Genes that share phenotypes with KAT8: view

Animal Models for KAT8 Gene

MGI Knock Outs for KAT8:

Animal Model Products

  • Taconic Biosciences Mouse Models for KAT8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KAT8 Gene

Localization for KAT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT8 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT8 Gene COMPARTMENTS Subcellular localization image for KAT8 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
genes like me logo Genes that share ontologies with KAT8: view

Pathways & Interactions for KAT8 Gene

genes like me logo Genes that share pathways with KAT8: view

Pathways by source for KAT8 Gene

1 GeneTex pathway for KAT8 Gene
1 BioSystems pathway for KAT8 Gene

SIGNOR curated interactions for KAT8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016573 histone acetylation IDA 11742995
genes like me logo Genes that share ontologies with KAT8: view

Drugs & Compounds for KAT8 Gene

(5) Drugs for KAT8 Gene - From: HMDB, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0
MG149 Pharma 0
Coenzyme A Nutra 0

(1) Additional Compounds for KAT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for KAT8 Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT8: view

Transcripts for KAT8 Gene

Unigene Clusters for KAT8 Gene

K(lysine) acetyltransferase 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT8 Gene

GeneLoc Exon Structure for
KAT8
ECgene alternative splicing isoforms for
KAT8

Expression for KAT8 Gene

mRNA expression in normal human tissues for KAT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT8 Gene

This gene is overexpressed in Blymphocyte (12.0), Peripheral blood mononuclear cells (11.0), CD8 Tcells (6.5), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT8 Gene



SOURCE GeneReport for Unigene cluster for KAT8 Gene Hs.533803

genes like me logo Genes that share expression patterns with KAT8: view

Protein tissue co-expression partners for KAT8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KAT8 Gene

Orthologs for KAT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KAT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KAT8 35
  • 92.72 (n)
  • 99.13 (a)
KAT8 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT8 35
  • 92.07 (n)
  • 98.47 (a)
MYST1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat8 35
  • 88.79 (n)
  • 98.25 (a)
Kat8 16
Kat8 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KAT8 35
  • 95.17 (n)
  • 94.8 (a)
KAT8 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat8 35
  • 88.69 (n)
  • 98.2 (a)
oppossum
(Monodelphis domestica)
Mammalia KAT8 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT8 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT8 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat8 35
  • 80.27 (n)
  • 90.8 (a)
Str.14579 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19273 35
zebrafish
(Danio rerio)
Actinopterygii kat8 35
  • 74.53 (n)
  • 85.84 (a)
wufb22g02 35
kat8 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012229 35
  • 66.41 (n)
  • 64.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta mof 35
  • 64.25 (n)
  • 60.47 (a)
CG1894 36
  • 30 (a)
OneToMany
mof 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mys-2 35
  • 52.62 (n)
  • 48.48 (a)
mys-2 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 36
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HAM1 35
  • 57.66 (n)
  • 54.86 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3525 35
barley
(Hordeum vulgare)
Liliopsida Hv.4361 35
rice
(Oryza sativa)
Liliopsida Os.9844 35
Os07g0626600 35
  • 57.18 (n)
  • 52.47 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5414 35
corn
(Zea mays)
Liliopsida Zm.4004 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.901 35
Species with no ortholog for KAT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KAT8 Gene

ENSEMBL:
Gene Tree for KAT8 (if available)
TreeFam:
Gene Tree for KAT8 (if available)

Paralogs for KAT8 Gene

Paralogs for KAT8 Gene

(7) SIMAP similar genes for KAT8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KAT8: view

Variants for KAT8 Gene

Sequence variations from dbSNP and Humsavar for KAT8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11800 -- 31,122,598(-) CCAGC(C/T)AAAAT intron-variant
rs1549293 -- 31,130,672(-) GGTAT(A/G)AGGAA intron-variant
rs1549294 -- 31,130,559(-) ATCTC(C/T)AGCAG reference, synonymous-codon
rs1549295 -- 31,130,505(-) GACAG(C/T)GGCTT reference, synonymous-codon
rs1137599 -- 31,123,686(+) TTTTT(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT8 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294
nsv905743 CNV Loss 21882294

Variation tolerance for KAT8 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT8 Gene

HapMap Linkage Disequilibrium report
KAT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT8 Gene

Disorders for KAT8 Gene

Relevant External Links for KAT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT8

No disorders were found for KAT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT8 Gene

Publications for KAT8 Gene

  1. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. (PMID: 10786633) Neal K.C. … Lucchesi J.C. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. (PMID: 17967868) Gupta A. … Pandita T.K. (Mol. Cell. Biol. 2008) 3 23
  3. The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. (PMID: 18058815) Pfister S. … Lichter P. (Int. J. Cancer 2008) 3 23
  4. hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. (PMID: 16024812) Taipale M. … Akhtar A. (Mol. Cell. Biol. 2005) 3 23
  5. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 3 23

Products for KAT8 Gene

Sources for KAT8 Gene

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