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Aliases for KAT8 Gene

Aliases for KAT8 Gene

  • K(Lysine) Acetyltransferase 8 2 3
  • MYST1 3 4 6
  • MOF 3 4 6
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 1 3 4
  • MYST Histone Acetyltransferase 1 2 3
  • Lysine Acetyltransferase 8 3 4
  • MYST-1 3 4
  • HMOF 3 4
  • Ortholog Of Drosophila Males Absent On The First (MOF) 3
  • Probable Histone Acetyltransferase MYST1 3
  • Histone Acetyltransferase MYST1 3
  • Histone Acetyltransferase KAT8 3
  • EC 2.3.1.48 4
  • ZC2HC8 3

External Ids for KAT8 Gene

Previous Symbols for KAT8 Gene

  • MYST1

Summaries for KAT8 Gene

Entrez Gene Summary for KAT8 Gene

  • This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for KAT8 Gene

KAT8 (K(Lysine) Acetyltransferase 8) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription factor binding and histone acetyltransferase activity. An important paralog of this gene is KAT7.

UniProtKB/Swiss-Prot for KAT8 Gene

  • Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at Lys-120.

Gene Wiki entry for KAT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT8 Gene

Genomics for KAT8 Gene

Genomic Location for KAT8 Gene

Start:
31,115,754 bp from pter
End:
31,131,393 bp from pter
Size:
15,640 bases
Orientation:
Plus strand

Genomic View for KAT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KAT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT8 Gene

No data available for Regulatory Elements for KAT8 Gene

Proteins for KAT8 Gene

  • Protein details for KAT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z6-KAT8_HUMAN
    Recommended name:
    Histone acetyltransferase KAT8
    Protein Accession:
    Q9H7Z6
    Secondary Accessions:
    • A8K4Z1
    • G5E9P2
    • Q659G0
    • Q7LC17
    • Q8IY59
    • Q8WYB4
    • Q8WZ14
    • Q9HAC5
    • Q9NR35

    Protein attributes for KAT8 Gene

    Size:
    458 amino acids
    Molecular mass:
    52403 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with MSL1; the interaction is direct. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KANSL1; the interaction is direct. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct.
    SequenceCaution:
    • Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAL56648.1; Type=Frameshift; Positions=23, 26, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT8 Gene

    Alternative splice isoforms for KAT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT8 Gene

Proteomics data for KAT8 Gene at MOPED

Post-translational modifications for KAT8 Gene

  • Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KAT8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KAT8 Gene

Domains for KAT8 Gene

Gene Families for KAT8 Gene

HGNC:
  • ZC2HC :Zinc fingers, C2HC-type containing
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases

UniProtKB/Swiss-Prot:

KAT8_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • Q9H7Z6
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.:
    • Q9H7Z6
Family:
  • Belongs to the MYST (SAS/MOZ) family.:
    • Q9H7Z6
Similarity:
  • Contains 1 C2HC-type zinc finger.:
    • Q9H7Z6
genes like me logo Genes that share domains with KAT8: view

Function for KAT8 Gene

Molecular function for KAT8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at Lys-120.

Enzyme Numbers (IUBMB) for KAT8 Gene

Gene Ontology (GO) - Molecular Function for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IDA 11742995
GO:0005515 protein binding IPI 11965546
GO:0008134 transcription factor binding IDA 11742995
GO:0016407 acetyltransferase activity IDA 11742995
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with KAT8: view
genes like me logo Genes that share phenotypes with KAT8: view

Animal Models for KAT8 Gene

MGI Knock Outs for KAT8:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for KAT8 Gene

Localization for KAT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT8 Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0000776 kinetochore IEA --
GO:0005634 nucleus IDA 11742995
GO:0005654 nucleoplasm TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with KAT8: view

Pathways for KAT8 Gene

genes like me logo Genes that share pathways with KAT8: view

Pathways by source for KAT8 Gene

1 BioSystems pathway for KAT8 Gene

Gene Ontology (GO) - Biological Process for KAT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0010506 regulation of autophagy IDA 23863932
GO:0016573 histone acetylation IDA 11742995
genes like me logo Genes that share ontologies with KAT8: view

Transcripts for KAT8 Gene

Unigene Clusters for KAT8 Gene

K(lysine) acetyltransferase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KAT8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT8 Gene

GeneLoc Exon Structure for
KAT8
ECgene alternative splicing isoforms for
KAT8

Expression for KAT8 Gene

mRNA expression in normal human tissues for KAT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT8 Gene

SOURCE GeneReport for Unigene cluster for KAT8 Gene Hs.533803

genes like me logo Genes that share expressions with KAT8: view

Orthologs for KAT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KAT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT8 36
  • 95.17 (n)
  • 94.8 (a)
KAT8 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KAT8 36
  • 92.72 (n)
  • 99.13 (a)
KAT8 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT8 36
  • 92.07 (n)
  • 98.47 (a)
MYST1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat8 36
  • 88.79 (n)
  • 98.25 (a)
Kat8 16
Kat8 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KAT8 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT8 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat8 36
  • 88.69 (n)
  • 98.2 (a)
lizard
(Anolis carolinensis)
Reptilia KAT8 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19273 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kat8 36
  • 80.27 (n)
  • 90.8 (a)
Str.14579 36
zebrafish
(Danio rerio)
Actinopterygii kat8 36
  • 74.53 (n)
  • 85.84 (a)
kat8 37
  • 74 (a)
OneToOne
wufb22g02 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012229 36
  • 66.41 (n)
  • 64.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1894 37
  • 30 (a)
OneToMany
mof 36
  • 64.25 (n)
  • 60.47 (a)
mof 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mys-2 36
  • 52.62 (n)
  • 48.48 (a)
mys-2 37
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 37
  • 35 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3525 36
thale cress
(Arabidopsis thaliana)
eudicotyledons HAM1 36
  • 57.66 (n)
  • 54.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4361 36
corn
(Zea mays)
Liliopsida Zm.4004 36
rice
(Oryza sativa)
Liliopsida Os.9844 36
Os07g0626600 36
  • 57.18 (n)
  • 52.47 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5414 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.901 36
Species with no ortholog for KAT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KAT8 Gene

ENSEMBL:
Gene Tree for KAT8 (if available)
TreeFam:
Gene Tree for KAT8 (if available)

Paralogs for KAT8 Gene

Paralogs for KAT8 Gene

Selected SIMAP similar genes for KAT8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KAT8: view

Variants for KAT8 Gene

Sequence variations from dbSNP and Humsavar for KAT8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11800 -- 31,122,598(-) CCAGC(C/T)AAAAT intron-variant
rs889548 -- 31,126,391(-) ATGTC(A/G)AGTCT intron-variant
rs1060506 -- 31,122,128(+) CCAGA(C/T)ATTTG intron-variant
rs1137599 -- 31,123,686(+) TTTTT(A/G)TTTTT intron-variant
rs1137603 -- 31,123,774(+) ctcaa(A/G)gtgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT8 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294
nsv905743 CNV Loss 21882294

Relevant External Links for KAT8 Gene

HapMap Linkage Disequilibrium report
KAT8

Disorders for KAT8 Gene

(1) Novoseek inferred disease relationships for KAT8 Gene

Disease -log(P) Hits PubMed IDs
chromosomal aberrations 41.9 1
genes like me logo Genes that share disorders with KAT8: view

No data available for UniProtKB/Swiss-Prot for KAT8 Gene

Publications for KAT8 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 3 4 23
  2. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PMID: 12397079) Pardo P.S. … Pereira-Smith O.M. (J. Biol. Chem. 2002) 3 4 23
  3. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. (PMID: 10786633) Neal K.C. … Lucchesi J.C. (Biochim. Biophys. Acta 2000) 2 3 4
  4. hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. (PMID: 16024812) Taipale M. … Akhtar A. (Mol. Cell. Biol. 2005) 3 23
  5. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. (PMID: 17967868) Gupta A. … Pandita T.K. (Mol. Cell. Biol. 2008) 3 23

Products for KAT8 Gene

  • Addgene plasmids for KAT8

Sources for KAT8 Gene

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