Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KAT7 Gene

Aliases for KAT7 Gene

  • K(Lysine) Acetyltransferase 7 2 3
  • Histone Acetyltransferase Binding To ORC1 2 3 4
  • MYST2 3 4 6
  • HBO1 3 4 6
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 2 3 4
  • MYST Histone Acetyltransferase 2 2 3
  • Lysine Acetyltransferase 7 3 4
  • MYST-2 3 4
  • HBOA 3 4
  • Histone Acetyltransferase MYST2 3
  • Histone Acetyltransferase KAT7 3
  • EC 2.3.1.48 4
  • ZC2HC7 3

External Ids for KAT7 Gene

Previous HGNC Symbols for KAT7 Gene

  • MYST2

Previous GeneCards Identifiers for KAT7 Gene

  • GC17P047867

Summaries for KAT7 Gene

GeneCards Summary for KAT7 Gene

KAT7 (K(Lysine) Acetyltransferase 7) is a Protein Coding gene. Among its related pathways are Androgen Signaling and Regulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and histone acetyltransferase activity. An important paralog of this gene is KAT8.

UniProtKB/Swiss-Prot for KAT7 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

Gene Wiki entry for KAT7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT7 Gene

Genomics for KAT7 Gene

Genomic Location for KAT7 Gene

Start:
49,788,555 bp from pter
End:
49,835,030 bp from pter
Size:
46,476 bases
Orientation:
Plus strand

Genomic View for KAT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KAT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT7 Gene

No data available for Regulatory Elements for KAT7 Gene

Proteins for KAT7 Gene

  • Protein details for KAT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95251-KAT7_HUMAN
    Recommended name:
    Histone acetyltransferase KAT7
    Protein Accession:
    O95251
    Secondary Accessions:
    • B3KN74
    • B4DF85
    • B4DFB4
    • B4DFE0
    • B4DGY4
    • E7ER15
    • G5E9K7

    Protein attributes for KAT7 Gene

    Size:
    611 amino acids
    Molecular mass:
    70642 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.

    Alternative splice isoforms for KAT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT7 Gene

Proteomics data for KAT7 Gene at MOPED

Post-translational modifications for KAT7 Gene

  • Autoacetylation at Lys-432 is required for proper function.
  • Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-85 and Thr-88 by CDK1.
  • Ubiquitination at Lys338 and Lys537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KAT7 Gene

Domains for KAT7 Gene

Gene Families for KAT7 Gene

HGNC:
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases
  • ZC2HC :Zinc fingers, C2HC-type containing

Protein Domains for KAT7 Gene

Graphical View of Domain Structure for InterPro Entry

O95251

UniProtKB/Swiss-Prot:

KAT7_HUMAN :
  • O95251
Domain:
  • The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
  • The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with KAT7: view

No data available for Suggested Antigen Peptide Sequences for KAT7 Gene

Function for KAT7 Gene

Molecular function for KAT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

Enzyme Numbers (IUBMB) for KAT7 Gene

Gene Ontology (GO) - Molecular Function for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 10930412
GO:0008270 zinc ion binding IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with KAT7: view
genes like me logo Genes that share phenotypes with KAT7: view

Animal Models for KAT7 Gene

MGI Knock Outs for KAT7:

miRNA for KAT7 Gene

miRTarBase miRNAs that target KAT7

No data available for Transcription Factor Targeting and HOMER Transcription for KAT7 Gene

Localization for KAT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT7 Gene

Nucleus, nucleoplasm.

Gene Ontology (GO) - Cellular Components for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 16387653
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KAT7: view

No data available for Subcellular locations from COMPARTMENTS for KAT7 Gene

Pathways for KAT7 Gene

genes like me logo Genes that share pathways with KAT7: view

Pathways by source for KAT7 Gene

Gene Ontology (GO) - Biological Process for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with KAT7: view

Transcripts for KAT7 Gene

Unigene Clusters for KAT7 Gene

K(lysine) acetyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KAT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KAT7 Gene

GeneLoc Exon Structure for
KAT7
ECgene alternative splicing isoforms for
KAT7

Expression for KAT7 Gene

mRNA expression in normal human tissues for KAT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT7 Gene

SOURCE GeneReport for Unigene cluster for KAT7 Gene Hs.21907

mRNA Expression by UniProt/SwissProt for KAT7 Gene

O95251-KAT7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis.
genes like me logo Genes that share expressions with KAT7: view

No data available for mRNA differential expression in normal tissues for KAT7 Gene

Orthologs for KAT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYST2 35
  • 99.45 (n)
  • 100 (a)
MYST2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KAT7 35
  • 94.76 (n)
  • 99.67 (a)
MYST2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT7 35
  • 93.94 (n)
  • 99.67 (a)
KAT7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat7 35
  • 91.43 (n)
  • 99.84 (a)
Kat7 16
Kat7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYST2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kat7 35
  • 91.6 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves MYST2 35
  • 83.63 (n)
  • 97.87 (a)
MYST2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT7 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68869 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kat7 35
  • 80.47 (n)
  • 94.71 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6107 35
kat7 35
  • 76.11 (n)
  • 86.11 (a)
kat7 36
  • 83 (a)
OneToMany
KAT7 (2 of 2) 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta chm 35
  • 56.17 (n)
  • 57.63 (a)
chm 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mys-4 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for KAT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT7 Gene

ENSEMBL:
Gene Tree for KAT7 (if available)
TreeFam:
Gene Tree for KAT7 (if available)

Paralogs for KAT7 Gene

Paralogs for KAT7 Gene

Selected SIMAP similar genes for KAT7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KAT7 Gene

genes like me logo Genes that share paralogs with KAT7: view

Variants for KAT7 Gene

Sequence variations from dbSNP and Humsavar for KAT7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs755736 -- 49,814,542(+) AAACT(A/G)AGACT intron-variant
rs906423 -- 49,814,868(-) AGAGA(C/T)CATTC intron-variant
rs1123339 -- 49,789,170(-) CCGCC(C/T)CCGCA intron-variant
rs1238024 -- 49,812,866(-) aatta(C/G)ccggg intron-variant
rs2279954 -- 49,821,119(+) ATACT(A/T)GTTCC intron-variant

Relevant External Links for KAT7 Gene

HapMap Linkage Disequilibrium report
KAT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KAT7 Gene

Disorders for KAT7 Gene

No disorders were found for KAT7 Gene.

No data available for UniProtKB/Swiss-Prot for KAT7 Gene

Publications for KAT7 Gene

  1. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PMID: 10438470) Iizuka M. … Stillman B. (J. Biol. Chem. 1999) 2 3 4 23
  2. Androgen receptor interacts with a novel MYST protein, HBO1. (PMID: 10930412) Sharma M. … Sun Z. (J. Biol. Chem. 2000) 2 3 4 23
  3. Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription. (PMID: 16645042) Georgiakaki M. … Loosfelt H. (Mol. Endocrinol. 2006) 3 23
  4. Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. (PMID: 19393168) Iizuka M. … Smith M.M. (Gene 2009) 3 23
  5. Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. (PMID: 11278932) Burke T.W. … Nevins J.R. (J. Biol. Chem. 2001) 3 4

Products for KAT7 Gene

Sources for KAT7 Gene

Back to Top

Content