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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KAT7 Gene

protein-coding   GIFtS: 54
GCID: GC17P047867

K(Lysine) Acetyltransferase 7

(Previous name: MYST histone acetyltransferase 2)
(Previous symbol: MYST2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
K(Lysine) Acetyltransferase 71 2     MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 22 3
MYST21 2 3 5     HBOA2
Histone Acetyltransferase Binding To ORC11 2 3     ZC2HC72
HBO12 3 5     Histone Acetyltransferase KAT72
MYST Histone Acetyltransferase 21 2     Histone Acetyltransferase MYST22
Lysine Acetyltransferase 72 3     EC 2.3.1.483
MYST-22 3     HBOa3

External Ids:    HGNC: 170161   Entrez Gene: 111432   Ensembl: ENSG000001365047   OMIM: 6098805   UniProtKB: O952513   

Export aliases for KAT7 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KAT7 Gene: 
KAT7 (K(lysine) acetyltransferase 7) is a protein-coding gene. Diseases associated with KAT7 include monocytic leukemia, and thyroiditis, and among its related super-pathways are Signal transduction Activin A signaling regulation. GO annotations related to this gene include histone acetyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot: KAT7_HUMAN, O95251
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription.
Specifically represses AR-mediated transcription

Gene Wiki entry for KAT7 (MYST2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KAT7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKAT7 promoter sequence
   Search SABiosciences Chromatin IP Primers for KAT7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.32

KAT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047867:  view genomic region     (about GC identifiers)

Start:
47,865,917 bp from pter      End:
47,906,458 bp from pter
Size:
40,542 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAT7_HUMAN, O95251 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT7  
Size: 611 amino acids; 70642 Da
Subunit: Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15,
PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of
dihydrotestosterone
Subcellular location: Nucleus, nucleoplasm
Secondary accessions: B3KN74 B4DF85 B4DFB4 B4DFE0 B4DGY4 E7ER15 G5E9K7
Alternative splicing: 5 isoforms:  O95251-1   O95251-2   O95251-3   O95251-4   O95251-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KAT7: NX_O95251

Explore proteomics data for KAT7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA
    replication licensing, and requires prior Phosphorylation at Thr-85 and Thr-88 by CDK1
  • UniProtKB: Autoacetylation at Lys-432 is required for proper function (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95251

  • KAT7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KAT7 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001186084.1  NP_001186085.1  NP_001186086.1  NP_001186087.1  NP_008998.1  

    ENSEMBL proteins: 
     ENSP00000259021   ENSP00000413415   ENSP00000424577   ENSP00000423385   ENSP00000398961  
     ENSP00000421368   ENSP00000409477   ENSP00000429939  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA16387653
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IDA16387653
    GO:0005730NOT nucleolus IDA16387653

    KAT7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    4 InterPro protein domains:
     IPR002515 Znf_C2HC
     IPR002717 MOZ_SAS
     IPR015880 Znf_C2H2-like
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry O95251

    ProtoNet protein and cluster: O95251

    1 Blocks protein domain: IPB002717 MOZ/SAS-like protein

    UniProtKB/Swiss-Prot: KAT7_HUMAN, O95251
    Domain: The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L
    Domain: The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction (By
    similarity)
    Similarity: Belongs to the MYST (SAS/MOZ) family
    Similarity: Contains 1 C2HC-type zinc finger


    KAT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT7_HUMAN, O95251
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
    acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription.
    Specifically represses AR-mediated transcription
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI10930412
    GO:0008270zinc ion binding IEA--
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    KAT7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for KAT7:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  Elongated cells  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kat7):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     mortality/aging 

    KAT7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kat7tm1.2Avo for KAT7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KAT7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KAT7

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    SwitchGear 3'UTR luciferase reporter plasmidKAT7 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KAT7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Histone modification0.31
    2Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    3Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KAT7
        Histone modification


    2 BioSystems Pathways for KAT7
        Androgen receptor signaling pathway
    Regulation of Androgen receptor activity




    KAT7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KAT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for KAT7 (O952511, 2, 3 ENSP000002590214) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS10438470
    GO:0043966histone H3 acetylation IDA16387653
    GO:0043981histone H4-K5 acetylation IDA16387653

    KAT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KAT7

    Search CenterWatch for drugs/clinical trials and news about KAT7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KAT7 gene (5 alternative transcripts): 
    NM_001199155.1  NM_001199156.1  NM_001199157.1  NM_001199158.1  NM_007067.4  

    Unigene Cluster for KAT7:

    K(lysine) acetyltransferase 7
    Hs.21907  [show with all ESTs]
    Unigene Representative Sequence: NM_007067
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000259021(uc002ipm.3 uc002ipl.2 uc010wma.2 uc010wmb.2 uc010wmc.2)
    ENST00000454930 ENST00000509773 ENST00000510819 ENST00000424009(uc010wmf.2 uc010wmg.2)
    ENST00000509124 ENST00000506533 ENST00000435742 ENST00000513171 ENST00000514540
    ENST00000513980 ENST00000512616 ENST00000508594 ENST00000509794 ENST00000510426
    ENST00000513075 ENST00000503101 ENST00000503635
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT7 (see all 69):
    hsa-miR-3607-3p hsa-miR-1914* hsa-miR-128 hsa-miR-134 hsa-miR-3142 hsa-miR-3150b-3p hsa-miR-149 hsa-miR-155*
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    Additional mRNA sequence: 

    AF074606.1 AF140360.1 AF217502.1 AK023890.1 AK293976.1 AK294014.1 AK294052.1 AK294367.1 
    AK294602.1 AK294836.1 AK295914.1 AK297212.1 BC015485.1 BC032640.2 

    21 DOTS entries:

    DT.95299807  DT.216516  DT.100026735  DT.100649914  DT.91771970  DT.91771972  DT.102830370  DT.99987631 
    DT.100654114  DT.100733282  DT.121300262  DT.91771965  DT.95208366  DT.100641942  DT.120954691  DT.120954714 
    DT.86852123  DT.91771967  DT.91771973  DT.95237644  DT.95293260 

    24/245 AceView cDNA sequences (see all 245):

    BQ061070 BX446886 Z41857 BU186005 CR618482 AU107974 BQ056668 AU134221 
    AA828394 AI637884 CA942695 BQ428577 AA744725 AF217502 AA322143 BM927485 
    BM451190 AA620680 AA598797 CB068380 BQ055533 BP352458 BM921163 BC032640 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KAT7 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
    SP1:        -                                         -     -     -     -                                                     -     -                           
    SP2:                                                  -     -     -     -                                                     -     -                           
    SP3:                                                        -     -     -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                    -                                                                                       

    ExUns: 19c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for KAT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KAT7 expression in normal human tissues (normalized intensities)      KAT7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCTGCTC
    KAT7 Expression
    About this image


    KAT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, pre-menopause ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   

    See KAT7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KAT7

    SOURCE GeneReport for Unigene cluster: Hs.21907

    UniProtKB/Swiss-Prot: KAT7_HUMAN, O95251
    Tissue specificity: Ubiquitously expressed, with highest levels in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including KAT7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KAT7 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat75
    Myst21
    MYST histone acetyltransferase 21, 5 91.43(n)1
    99.84(a)1
      11 (59.01 cM)5
    2171271  NM_001195003.11  NP_001181932.11 
     952742595 
    chicken
    (Gallus gallus)
    Aves MYST21 MYST histone acetyltransferase 2 83.63(n)
    97.87(a)
      425530  NM_001031341.1  NP_001026512.1 
    lizard
    (Anolis carolinensis)
    Reptilia KAT76
    Uncharacterized protein
    95(a)
    1 ↔ 1
    6(76859588-76882814)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688692 hypothetical protein MGC68869 79.97(n)    BC059293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.61072 Danio rerio mRNA similar to histone acetyltransferase more 77.68(n)    BC045314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chm1 chameau 50.03(n)
    48.69(a)
      43928  NM_135273.4  NP_609117.4 
    worm
    (Caenorhabditis elegans)
    Secernentea mys-46
    Protein MYS-4
    21(a)
    1 → many
    I(8333154-8336183)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESA16
    Catalytic subunit of the histone acetyltransferase...
    35(a)
    1 → many
    XV(792531-793868)
    soybean
    (Glycine max)
    eudicotyledons CA801909.12   -- 74.97(n)    CA801909.1 


    ENSEMBL Gene Tree for KAT7 (if available)
    TreeFam Gene Tree for KAT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KAT7 gene
    KAT6B2  KAT52  KAT6A2  KAT82  
    7 SIMAP similar genes for KAT7 using alignment to 4 protein entries:     KAT7_HUMAN (see all proteins):
    KAT6A    DKFZp313G1618    KAT5    MYST3    KAT8    KAT6B
    MYST4

    KAT7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KAT7
    PGOHUM00000241454


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/701 SNPs in KAT7 are shown (see all 701)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346993261,2
    C--47873414(+) TTGAA-/TTTTCC 5 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs572326621,2
    C--47896105(+) TCTTG-/TTTTTT 5 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs585529861,2
    C,F--48877365(+) GTGGCG/AGGCGC 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1932244001,2
    --48877395(+) GGAGGC/TTGAGG 5 -- us2k10--------
    rs579467161,2
    C--48877514(+) AAAAA-/A/GGAAAG 5 -- us2k10--------
    rs1843865401,2
    --48877657(+) AATTAA/GCCAGG 5 -- us2k10--------
    rs2021424531,2
    --48877808(+) GAAAG-/AAAAAA 5 -- us2k10--------
    rs1887784341,2
    --48877855(+) TAACTC/GAGATA 5 -- us2k10--------
    rs1812119511,2
    --48877920(+) GTAACC/TTCAGG 5 -- us2k10--------
    rs750771231,2
    F--48877935(+) TATCCG/TTGAGT 5 -- us2k11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for KAT7 (47865917 - 47906458 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KAT7: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KAT7
    DNA2.0 Custom Variant and Variant Library Synthesis for KAT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609880    OMIM disorders: --

    4 diseases for KAT7:    About MalaCards
    monocytic leukemia    thyroiditis    leukemia    breast cancer


    KAT7 for disorders           About GeneDecksing


    Export disorders for KAT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KAT7 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with KAT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Androgen receptor interacts with a novel MYST protein, HBO1. (PubMed id 10930412)1, 2, 3, 9 Sharma M....Sun Z. (2000)
    2. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PubMed id 10438470)1, 2, 3, 9 Iizuka M. and Stillman B. (1999)
    3. Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. (PubMed id 18250300)1, 2 Wu Z.Q. and Liu X. (2008)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. (PubMed id 11278932)1, 2 Burke T.W.... Nevins J.R. (2001)
    10. Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription. (PubMed id 16645042)1, 9 Georgiakaki M....Loosfelt H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11143 HGNC: 17016 AceView: MYST2 Ensembl:ENSG00000136504 euGenes: HUgn11143
    ECgene: KAT7 H-InvDB: KAT7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KAT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KAT7 gene:
    Search GeneIP for patents involving KAT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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