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Aliases for KAT7 Gene

Aliases for KAT7 Gene

  • Lysine Acetyltransferase 7 2 3 4
  • Histone Acetyltransferase Binding To ORC1 2 3 4
  • K(Lysine) Acetyltransferase 7 2 3 5
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 2 3 4
  • MYST Histone Acetyltransferase 2 2 3
  • MYST-2 3 4
  • MYST2 3 4
  • HBOA 3 4
  • HBO1 3 4
  • Histone Acetyltransferase MYST2 3
  • EC 2.3.1.48 4
  • ZC2HC7 3

External Ids for KAT7 Gene

Previous HGNC Symbols for KAT7 Gene

  • MYST2

Previous GeneCards Identifiers for KAT7 Gene

  • GC17P047867

Summaries for KAT7 Gene

GeneCards Summary for KAT7 Gene

KAT7 (Lysine Acetyltransferase 7) is a Protein Coding gene. Among its related pathways are Chromatin organization and Androgen receptor signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is KAT8.

UniProtKB/Swiss-Prot for KAT7 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

Gene Wiki entry for KAT7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT7 Gene

Genomics for KAT7 Gene

Regulatory Elements for KAT7 Gene

Promoters for KAT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KAT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for KAT7 Gene

Chromosome:
17
Start:
49,788,555 bp from pter
End:
49,835,030 bp from pter
Size:
46,476 bases
Orientation:
Plus strand

Genomic View for KAT7 Gene

Genes around KAT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT7 Gene

Proteins for KAT7 Gene

  • Protein details for KAT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95251-KAT7_HUMAN
    Recommended name:
    Histone acetyltransferase KAT7
    Protein Accession:
    O95251
    Secondary Accessions:
    • B3KN74
    • B4DF85
    • B4DFB4
    • B4DFE0
    • B4DGY4
    • E7ER15
    • G5E9K7

    Protein attributes for KAT7 Gene

    Size:
    611 amino acids
    Molecular mass:
    70642 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.

    Alternative splice isoforms for KAT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT7 Gene

Proteomics data for KAT7 Gene at MOPED

Post-translational modifications for KAT7 Gene

  • Autoacetylation at Lys-432 is required for proper function.
  • Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-85 and Thr-88 by CDK1.
  • Ubiquitination at Lys 338 and Lys 537
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT7 (MYST2)

No data available for DME Specific Peptides for KAT7 Gene

Domains & Families for KAT7 Gene

Protein Domains for KAT7 Gene

Graphical View of Domain Structure for InterPro Entry

O95251

UniProtKB/Swiss-Prot:

KAT7_HUMAN :
  • The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
  • Belongs to the MYST (SAS/MOZ) family.
  • Contains 1 C2HC-type zinc finger.
Domain:
  • The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
  • The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with KAT7: view

Function for KAT7 Gene

Molecular function for KAT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

Enzyme Numbers (IUBMB) for KAT7 Gene

Gene Ontology (GO) - Molecular Function for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10930412
genes like me logo Genes that share ontologies with KAT7: view
genes like me logo Genes that share phenotypes with KAT7: view

Animal Models for KAT7 Gene

MGI Knock Outs for KAT7:

Animal Model Products

miRNA for KAT7 Gene

miRTarBase miRNAs that target KAT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT7 Gene

Localization for KAT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT7 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT7 Gene COMPARTMENTS Subcellular localization image for KAT7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KAT7: view

Pathways & Interactions for KAT7 Gene

genes like me logo Genes that share pathways with KAT7: view

Pathways by source for KAT7 Gene

1 GeneTex pathway for KAT7 Gene
1 Qiagen pathway for KAT7 Gene

SIGNOR curated interactions for KAT7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006351 transcription, DNA-templated IEA --
GO:0016573 histone acetylation IEA --
GO:0043966 histone H3 acetylation IDA 16387653
GO:0043982 histone H4-K8 acetylation IDA 16387653
genes like me logo Genes that share ontologies with KAT7: view

Drugs & Compounds for KAT7 Gene

(4) Drugs for KAT7 Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0
Coenzyme A Nutra 0

(1) Additional Compounds for KAT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for KAT7 Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT7: view

Transcripts for KAT7 Gene

Unigene Clusters for KAT7 Gene

K(lysine) acetyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KAT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KAT7 Gene

GeneLoc Exon Structure for
KAT7
ECgene alternative splicing isoforms for
KAT7

Expression for KAT7 Gene

mRNA expression in normal human tissues for KAT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7), CD8 Tcells (12.3), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT7 Gene



SOURCE GeneReport for Unigene cluster for KAT7 Gene Hs.21907

mRNA Expression by UniProt/SwissProt for KAT7 Gene

O95251-KAT7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis.
genes like me logo Genes that share expression patterns with KAT7: view

Protein tissue co-expression partners for KAT7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KAT7 Gene

Orthologs for KAT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KAT7 35
  • 94.76 (n)
  • 99.67 (a)
MYST2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT7 35
  • 93.94 (n)
  • 99.67 (a)
KAT7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat7 35
  • 91.43 (n)
  • 99.84 (a)
Kat7 16
Kat7 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYST2 35
  • 99.45 (n)
  • 100 (a)
MYST2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat7 35
  • 91.6 (n)
  • 99.67 (a)
oppossum
(Monodelphis domestica)
Mammalia MYST2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MYST2 35
  • 83.63 (n)
  • 97.87 (a)
MYST2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT7 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat7 35
  • 80.47 (n)
  • 94.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68869 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6107 35
kat7 35
  • 76.11 (n)
  • 86.11 (a)
kat7 36
  • 83 (a)
OneToMany
KAT7 (2 of 2) 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta chm 35
  • 56.17 (n)
  • 57.63 (a)
chm 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mys-4 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for KAT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT7 Gene

ENSEMBL:
Gene Tree for KAT7 (if available)
TreeFam:
Gene Tree for KAT7 (if available)

Paralogs for KAT7 Gene

Paralogs for KAT7 Gene

(7) SIMAP similar genes for KAT7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KAT7 Gene

genes like me logo Genes that share paralogs with KAT7: view

Variants for KAT7 Gene

Sequence variations from dbSNP and Humsavar for KAT7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1123339 -- 49,789,170(-) CCGCC(C/T)CCGCA intron-variant
rs906423 -- 49,814,868(-) AGAGA(C/T)CATTC intron-variant, upstream-variant-2KB
rs755736 -- 49,814,542(+) AAACT(A/G)AGACT intron-variant, upstream-variant-2KB
rs1238024 -- 49,812,866(-) aatta(C/G)ccggg intron-variant
rs2279954 -- 49,821,119(+) ATACT(A/T)GTTCC intron-variant

Variation tolerance for KAT7 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT7 Gene

HapMap Linkage Disequilibrium report
KAT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KAT7 Gene

Disorders for KAT7 Gene

Relevant External Links for KAT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT7

No disorders were found for KAT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT7 Gene

Publications for KAT7 Gene

  1. Androgen receptor interacts with a novel MYST protein, HBO1. (PMID: 10930412) Sharma M. … Sun Z. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PMID: 10438470) Iizuka M. … Stillman B. (J. Biol. Chem. 1999) 2 3 23
  3. Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. (PMID: 19393168) Iizuka M. … Smith M.M. (Gene 2009) 3 23
  4. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. (PMID: 18684714) Foy R.L. … Panchenko M.V. (J. Biol. Chem. 2008) 3 23
  5. Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription. (PMID: 16645042) Georgiakaki M. … Loosfelt H. (Mol. Endocrinol. 2006) 3 23

Products for KAT7 Gene

Sources for KAT7 Gene

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