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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KAT6A Gene

protein-coding   GIFtS: 49
GCID: GC08M041786

K(lysine) acetyltransferase 6A

(Previous names: runt-related transcription factor binding protein 2, MYST...)
(Previous symbols: ZNF220, RUNXBP2, MYST3)
 Explore 21 diseases affiliated with
KAT6A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KAT6A    

Aliases
for KAT6A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
K(Lysine) Acetyltransferase 6A1 2     Runt-Related Transcription Factor-Binding Protein 22 3
MOZ1 2 3 5     Zinc Finger Protein 2202 3
MYST31 2 3 5     MYST-32 3
ZNF2201 2 3 5     Monocytic Leukemia Zinc Finger Protein2 3
RUNXBP21 2 3     MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 32 3
ZC2HC6A1 2     Histone Acetyltransferase KAT6A2
MYST Histone Acetyltransferase (Monocytic Leukemia) 31 2     Histone Acetyltransferase MYST32
Runt-Related Transcription Factor Binding Protein 21 2     EC 2.3.1.483

External Ids:    HGNC: 130131   Entrez Gene: 79942   Ensembl: ENSG000000831687   OMIM: 6014085   UniProtKB: Q927943   

Export aliases for KAT6A gene to outside databases


Summaries
for KAT6A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component
of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator
for RUNX1 and RUNX2

Gene Wiki entry for KAT6A (MYST3)


Genomic Views
for KAT6A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KAT6A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KAT6A promoter sequence
   Search SABiosciences Chromatin IP Primers for KAT6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11

KAT6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT6A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M041786:  view genomic region     (about GC identifiers)

Start:
 41,786,997 bp from pter      End:
 41,909,508 bp from pter
Size:
 122,512 bases      Orientation:
 minus strand

Proteins
for KAT6A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT6A  
Size: 2004 amino acids; 225028 Da
Subunit: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2
and BRPF3. Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction. Interacts with RUNX2
Subcellular location: Nucleus. Note=Partially concentrated in subnuclear foci distinct from PML bodies, and excluded
from the nucleoli
5 PDB 3D structures from and Proteopedia for KAT6A:
1M36 (3D)        2LN0 (3D)        2OZU (3D)        2RC4 (3D)        3V43 (3D)    
Secondary accessions: Q76L81

Explore the universe of human proteins at neXtProt for KAT6A: NX_Q92794

Post-translational modifications:

  • Autoacetylated1
  • Autoacetylation at Lys-604 is required for proper function (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92794

    • KAT6A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001092882.1  NP_001092883.1  NP_006757.2  

    ENSEMBL proteins: 
     ENSP00000265713   ENSP00000385888   ENSP00000399638   ENSP00000430606   ENSP00000396699  
     ENSP00000380136  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KAT6A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA18794358
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653


    KAT6A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KAT6A

    Protein Domains /
    Families
    for KAT6A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KAT6A for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR002717 MOZ_SAS
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92794

    ProtoNet protein and cluster: Q92794

    4 Blocks protein families:
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB002717 MOZ/SAS-like protein
    IPB005818 Histone H1/H5


    UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
    Domain: The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional
    repression
    Similarity: Belongs to the MYST (SAS/MOZ) family
    Similarity: Contains 1 C2HC-type zinc finger
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain
    Similarity: Contains 2 PHD-type zinc fingers


    Function
    for KAT6A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
    Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component
    of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator
    for RUNX1 and RUNX2
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

    Enzyme Number (IUBMB): EC 2.3.1.481

    miRNA
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    hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-374a hsa-miR-3921 hsa-miR-3916 hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: KAT6A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA17925393
    GO:0003713transcription coactivator activity TAS18794358
    GO:0004402histone acetyltransferase activity IDA17925393
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IDA11965546


    KAT6A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KAT6A:
     Decreased Salmonella enterica   Increased cell death in HCC-19  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-outs for KAT6A: Kat6atm2.2Avo Kat6atm1Iki Kat6atm1Avo
         15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Kat6a) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 

    KAT6A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KAT6A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Histone modification0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KAT6A
        Histone modification




    KAT6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KAT6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for KAT6A (Q927941, 3 ENSP000002657134) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006323DNA packaging TAS8782817
    GO:0006334nucleosome assembly IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0016573histone acetylation IDA17925393


    KAT6A for ontologies           About GeneDecksing



    Drugs & Compounds
    for KAT6A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KAT6A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KAT6A
    1 Novoseek chemical compound relationship for KAT6A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 42.8 14 10497217 (2), 9731070 (2), 11243405 (2), 8782817 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about KAT6A 

    Transcripts
    for KAT6A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KAT6A gene (3 alternative transcripts): 
    NM_001099412.1  NM_001099413.1  NM_006766.3  

    Unigene Cluster for KAT6A:

    K(lysine) acetyltransferase 6A
    Hs.491577  [show with all ESTs]
    Unigene Representative Sequence: NM_001099412
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265713(uc003xon.4) ENST00000406337(uc010lxc.3) ENST00000418721
    ENST00000485568(uc010lxd.3) ENST00000470574 ENST00000463961 ENST00000426524
    ENST00000396930(uc010lxb.3)

    miRNA
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    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT6A (see all 86):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-374a hsa-miR-3921 hsa-miR-3916 hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: KAT6A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KAT6A (see all 7)
    OriGene shRNA RFP: KAT6A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT6A
    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ420560.1 AK027361.1 AK128323.1 BC018011.1 BC142659.1 BC142959.1 U47742.1 

    11 DOTS entries:

    DT.116553  DT.95167178  DT.97783556  DT.95167182  DT.97824812  DT.120633870  DT.92435594  DT.97841146 
    DT.120633834  DT.120633876  DT.92435587 

    24/202 AceView cDNA sequences (see all 202):

    BE218412 AA612635 BE670093 AI656249 CD672253 BE222315 BF110806 AI760188 
    AL045033 BE671622 AW590549 AA310750 CB141318 AW058356 AA583238 AW473405 
    AI969731 AI655854 W92572 AL582993 AA364208 CD672254 AA777772 AA777633 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT6A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:              -     -                                                                 -     -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for KAT6A

    Expression
    for KAT6A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KAT6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACGCGCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KAT6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KAT6A

    SOURCE GeneReport for Unigene cluster: Hs.491577
        SABiosciences Expression via Pathway-Focused PCR Array including KAT6A: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for KAT6A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KAT6A gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYST31 MYST histone acetyltransferase (monocytic leukemia) more 80.85(n)
    85.74(a)    		   426789  XM_424402.3  XP_424402.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KAT6A6
    --
    		 --
    		 82(a)
    30(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343545.1(224878-271496)
    GL343196.1(2273979-2316803)
    zebrafish
    (Danio rerio)    		 Actinopterygii kat6a1 K(lysine) acetyltransferase 6A 60.33(n)
    63(a)    		   266966  NM_001123312.3  NP_001116784.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta enok1 enoki mushroom 41.94(n)
    30.3(a)    		   37859  NM_079114.1  NP_523838.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mys-46
    lsy-126
    		 MYST family histone acetyltransferase-like family ...
    MYST family histone acetyltransferase-like family ...
    		 20(a)
    16(a)
    		 possible ortholog
    1 ↔ many
    		 I(8333147-8336176)
    V(9846133-9859939)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HAM26
    HAM16
    		 histone acetyltransferase MYST1
    		 36(a)
    36(a)
    		 many ↔ many
    many ↔ many
    		 5(3021952-3024756)
    5(25828160-25830524)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 MYST-like histone acetyltransferase 1, putative, e...
    		 35(a)
    		 1 → many
    		 7(25957775-25962658)


    ENSEMBL Gene Tree for KAT6A (if available)
    TreeFam Gene Tree for KAT6A (if available) 

    Paralogs
    for KAT6A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KAT6A gene
    KAT6B2  KAT72  KAT52  KAT82  
    10 SIMAP similar genes for KAT6A using alignment to 3 protein entries:     KAT6A_HUMAN (see all proteins):
    MOZ/CBP    MYST3    KAT7    CBP/MOZ    DKFZp313G1618    KAT5
    KAT8    MYST4    KAT6B    MORF/CBP

    KAT6A for paralogs           About GeneDecksing



    Genomic Variants
    for KAT6A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1835 NCBI SNPs in KAT6A are shown (see all 1835)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1144072081,2
    		C,F,--41786536(+) ATGACG/AAATCT 3 -- ds50012Minor allele frequency- A:0.02WA EA 238
    rs1171719221,2
    		F,--41786776(+) TTACCG/ATGCCA 3 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1388701881,2
    		--41786820(+) TTGGCA/GTTTAA 3 -- ds50010--------
    rs1432307461,2
    		--41787044(+) ACAGAA/GTTCTT 3 -- ut310--------
    rs1474766631,2
    		--41787095(+) TACAAG/TGAGAG 3 -- ut310--------
    rs1399559161,2
    		--41787128(+) GAGCGC/TGTGAC 3 -- ut310--------
    rs115518081,2
    		--41787156(+) CATCTA/TGGCAC 3 -- ut310--------
    rs1860227191,2
    		--41787249(+) TAGACG/TTGGCT 3 -- ut310--------
    rs1913092561,2
    		--41787260(+) TCCTTG/TGTACA 3 -- ut310--------
    rs29399831,2
    		C,H--41787294(-) GTGAAT/CAGAGC 3 -- ut316Minor allele frequency- C:0.00NS EA NA 422

    HapMap Linkage Disequilibrium report for KAT6A (41786997 - 41909508 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KAT6A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KAT6A
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    Disorders / Diseases
    for KAT6A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KAT6A for disorders           About GeneDecksing

    OMIM gene information: 601408    OMIM disorders: --

    UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
  • Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation
    • t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by
    inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists
    of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its
    function in transcription activation
  • Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome.
    • Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein

    20/21 diseases for KAT6A (see all 21):    About MalaCards
    monocytic leukemia    leukemia    acute monocytic leukemia    myelomonocytic leukemia
    non-hodgkin lymphoma    acute myelomonocytic leukemia    chronic myelomonocytic leukemia    prolymphocytic leukemia
    acute promyelocytic leukemia    hodgkin's lymphoma    acute myeloid leukemia    myeloid leukemia
    neonatal leukemia    myelodysplastic syndrome    hermaphroditism    hematopoiesis
    pharyngitis    ataxia    immunodeficiency    malaria

    5 Novoseek disease relationships for KAT6A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monocytic leukemia 86.6 11 10497217 (2), 17694082 (1), 10824998 (1), 9731070 (1) (see all 6)
    acute monocytic leukemia 86.2 5 10824998 (2), 9731070 (1), 11243405 (1)
    leukemogenesis 76.8 3 10824998 (1), 12893170 (1), 15160929 (1)
    leukemia 59.6 10 18657848 (1), 10862050 (1), 12771199 (1), 17697320 (1) (see all 10)
    chromosomal aberrations 48.4 2 14960713 (1), 12893170 (1)


    Export disorders for KAT6A gene to outside databases

    Publications
    for KAT6A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KAT6A gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with KAT6A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. (PubMed id 8782817)1, 2, 3, 9 Borrow J.... Housman D.E. (1996)
    2. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. (PubMed id 11742995)1, 2, 9 Kitabayashi I.... Ohki M. (2001)
    3. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (PubMed id 10824998)1, 2, 9 Chaffanet M....Pebusque M.-J. (2000)
    4. Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ. (PubMed id 12771199)1, 2, 9 Bristow C.A.P. and Shore P. (2003)
    5. MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. (PubMed id 11965546)1, 2, 9 Pelletier N.... Yang X.-J. (2002)
    6. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. (PubMed id 9558366)1, 2, 9 Carapeti M.... Cross N.C.P. (1998)
    7. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (2008)
    8. The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. (PubMed id 17925393)1, 2 Holbert M.A....Marmorstein R. (2007)
    9. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)
    10. MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. (PubMed id 15657427)1, 2 Kindle K.B....Heery D.M. (2005)

    External Searches for KAT6A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing KAT6A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7994 HGNC: 13013 AceView: MYST3 Ensembl:ENSG00000083168 euGenes: HUgn7994
    ECgene: KAT6A H-InvDB: KAT6A

    Other Databases showing KAT6A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KAT6A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KAT6A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KAT6A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KAT6A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KAT6A gene:
    Search GeneIP for patents involving KAT6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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