Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KAT6A Gene

protein-coding   GIFtS: 53
GCID: GC08M041786

K(Lysine) Acetyltransferase 6A

(Previous names: runt-related transcription factor binding protein 2, MYST...)
(Previous symbols: ZNF220, RUNXBP2, MYST3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
K(Lysine) Acetyltransferase 6A1 2     Runt-Related Transcription Factor-Binding Protein 22 3
MYST31 2 3 5     Zinc Finger Protein 2202 3
ZNF2201 2 3 5     MYST-32 3
RUNXBP21 2 3     MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 32 3
Monocytic Leukemia Zinc Finger Protein1 2 3     ZC2HC6A2
MOZ2 3 5     Histone Acetyltransferase KAT6A2
MYST Histone Acetyltransferase (Monocytic Leukemia) 31 2     Histone Acetyltransferase MYST32
Runt-Related Transcription Factor Binding Protein 21 2     EC 2.3.1.483

External Ids:    HGNC: 130131   Entrez Gene: 79942   Ensembl: ENSG000000831687   OMIM: 6014085   UniProtKB: Q927943   

Export aliases for KAT6A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KAT6A Gene: 
KAT6A (K(lysine) acetyltransferase 6A) is a protein-coding gene. Diseases associated with KAT6A include neonatal leukemia, and acute monocytic leukemia, and among its related super-pathways are Signal transduction Activin A signaling regulation. GO annotations related to this gene include histone acetyltransferase activity and transcription factor binding. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro).
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional
coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional
activity via association with PML

Gene Wiki entry for KAT6A (MYST3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KAT6A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKAT6A promoter sequence
   Search SABiosciences Chromatin IP Primers for KAT6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11

KAT6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT6A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M041786:  view genomic region     (about GC identifiers)

Start:
41,786,997 bp from pter      End:
41,909,508 bp from pter
Size:
122,512 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT6A  
Size: 2004 amino acids; 225028 Da
Subunit: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1,
BRD1/BRPF2 and BRPF3. Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction. Interacts with
RUNX2. Interacts with p53/TP53. Interacts with PML (isoform PML-4) and this interaction positively regulates its
acetylation activity towards p53/TP53
Subcellular location: Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into
PML body after DNA damage
5 PDB 3D structures from and Proteopedia for KAT6A:
1M36 (3D)        2LN0 (3D)        2OZU (3D)        2RC4 (3D)        3V43 (3D)    
Secondary accessions: Q76L81

Explore the universe of human proteins at neXtProt for KAT6A: NX_Q92794

Explore proteomics data for KAT6A at MOPED 

Post-translational modifications:

  • UniProtKB: Autoacetylation at Lys-604 is required for proper function (By similarity). Autoacetylated
  • UniProtKB: Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation
    activity towards p53/TP53
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92794

  • KAT6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KAT6A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001092882.1  NP_001092883.1  NP_006757.2  

    ENSEMBL proteins: 
     ENSP00000265713   ENSP00000385888   ENSP00000399638   ENSP00000430606   ENSP00000396699  
     ENSP00000380136  

    Human Recombinant Protein Products for KAT6A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KAT6A
    GenScript Custom Purified and Recombinant Proteins Services for KAT6A
    Novus Biologicals KAT6A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA11742995
    GO:0005730nucleolus IEA--
    GO:0016605PML body IDA--
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    KAT6A for ontologies           About GeneDecksing



    KAT6A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KAT6A
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KAT6A
    GenScript Custom Superior Antibodies Services for KAT6A
    Novus Biologicals KAT6A Antibodies
    Abcam antibodies for KAT6A
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for KAT6A
    LSBio Antibodies in human, mouse, rat for KAT6A 

    Assay Products for KAT6A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KAT6A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KAT6A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    PHF: Zinc fingers, PHD-type

    5/8 InterPro protein domains (see all 8):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR002717 MOZ_SAS
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92794

    ProtoNet protein and cluster: Q92794

    4 Blocks protein domains:
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB002717 MOZ/SAS-like protein
    IPB005818 Histone H1/H5


    UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
    Domain: The N-terminus is involved in transcriptional activation while the C-terminus is involved in
    transcriptional repression
    Similarity: Belongs to the MYST (SAS/MOZ) family
    Similarity: Contains 1 C2HC-type zinc finger
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain
    Similarity: Contains 2 PHD-type zinc fingers


    KAT6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT6A_HUMAN, Q92794
    Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro).
    Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional
    coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional
    activity via association with PML
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA17925393
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity TAS18794358
    GO:0004402histone acetyltransferase activity IDA11742995
    GO:0005515protein binding IPI11742995
         
    KAT6A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KAT6A:
     Decreased Salmonella enterica   Increased cell death in HCC-19  Synthetic lethal with imatinib 

         15/17 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kat6a) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 

    KAT6A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KAT6A: Kat6atm2.2Avo Kat6atm1Iki Kat6atm1Avo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KAT6A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KAT6A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KAT6A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KAT6A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KAT6A
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT6A (see all 86):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-374a hsa-miR-3921 hsa-miR-3916 hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKAT6A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KAT6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT6A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KAT6A
    Sirion Biotech Customized adenovirus for overexpression of KAT6A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KAT6A (see all 13)
    OriGene ORF clones in mouse, rat for KAT6A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KAT6A
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT6A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KAT6A
    Search LifeMap BioReagents cell lines for KAT6A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT6A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KAT6A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Histone modification0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KAT6A
        Histone modification




    KAT6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KAT6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for KAT6A (Q927941, 3 ENSP000002657134) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003007heart morphogenesis IEA--
    GO:0006323DNA packaging TAS8782817
    GO:0006334nucleosome assembly IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    KAT6A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KAT6A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KAT6A

    1 Novoseek inferred chemical compound relationship for KAT6A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 42.8 14 10497217 (2), 9731070 (2), 11243405 (2), 8782817 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about KAT6A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KAT6A gene (3 alternative transcripts): 
    NM_001099412.1  NM_001099413.1  NM_006766.3  

    Unigene Cluster for KAT6A:

    K(lysine) acetyltransferase 6A
    Hs.491577  [show with all ESTs]
    Unigene Representative Sequence: NM_001099412
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265713(uc003xon.4) ENST00000406337(uc010lxc.3) ENST00000418721
    ENST00000485568(uc010lxd.3) ENST00000470574 ENST00000463961 ENST00000426524
    ENST00000396930(uc010lxb.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KAT6A
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT6A (see all 86):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-374a hsa-miR-3921 hsa-miR-3916 hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKAT6A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KAT6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT6A
    Clone
    Products:
         
    OriGene clones in human, mouse for KAT6A (see all 13)
    OriGene ORF clones in mouse, rat for KAT6A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KAT6A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT6A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KAT6A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KAT6A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT6A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT6A

    Additional mRNA sequence: 

    AJ420560.1 AK027361.1 AK128323.1 BC018011.1 BC142659.1 BC142959.1 U47742.1 

    11 DOTS entries:

    DT.116553  DT.95167178  DT.97783556  DT.95167182  DT.97824812  DT.120633870  DT.92435594  DT.97841146 
    DT.120633834  DT.120633876  DT.92435587 

    24/202 AceView cDNA sequences (see all 202):

    AA777633 AI969731 BM819207 AW590549 AL582993 CD672253 AK128323 AI648575 
    BE222315 AA612635 W92573 BE671622 AA777772 AI655854 BQ014169 AA364208 
    BP375341 CB141318 AL045033 AU185587 AW237182 CA433366 CD672254 AW473405 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT6A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:              -     -                                                                 -     -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for KAT6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KAT6A expression in normal human tissues (normalized intensities)      KAT6A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACGCGCTC
    KAT6A Expression
    About this image


    KAT6A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             neutrophils   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             retinal progenitor cell e12.5   
     
     Breast (Uncategorized)
             breast stroma   
     
     Bone (Muscoskeletal System)
             Mandibular Condyle

    See KAT6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KAT6A

    SOURCE GeneReport for Unigene cluster: Hs.491577
        SABiosciences Expression via Pathway-Focused PCR Array including KAT6A: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KAT6A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KAT6A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT6A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT6A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT6A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KAT6A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat6a5
    Myst31
    MYST histone acetyltransferase (monocytic leukemia) more1, 5 86.8(n)1
    89.66(a)1
      8 (11.42 cM)5
    2443491  NM_001081149.11  NP_001074618.11 
     228595355 
    chicken
    (Gallus gallus)
    Aves MYST31 MYST histone acetyltransferase (monocytic leukemia) more 80.85(n)
    85.74(a)
      426789  XM_424402.3  XP_424402.2 
    lizard
    (Anolis carolinensis)
    Reptilia KAT6A6
    K(lysine) acetyltransferase 6A
    79(a)
    1 ↔ 1
    GL343545.1(224878-271831)
    zebrafish
    (Danio rerio)
    Actinopterygii kat6a1 K(lysine) acetyltransferase 6A 60.33(n)
    63(a)
      266966  NM_001123312.3  NP_001116784.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta enok1 enoki mushroom 41.94(n)
    30.3(a)
      37859  NM_079114.1  NP_523838.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mys-46
    Protein MYS-4
    28(a)
    1 → many
    I(8333154-8336183)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESA16
    Catalytic subunit of the histone acetyltransferase...
    36(a)
    1 → many
    XV(792531-793868)


    ENSEMBL Gene Tree for KAT6A (if available)
    TreeFam Gene Tree for KAT6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KAT6A gene
    KAT6B2  KAT52  KAT72  KAT82  
    10 SIMAP similar genes for KAT6A using alignment to 3 protein entries:     KAT6A_HUMAN (see all proteins):
    MOZ/CBP    MYST3    KAT7    CBP/MOZ    DKFZp313G1618    KAT5
    KAT8    MYST4    KAT6B    MORF/CBP

    KAT6A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2279 SNPs in KAT6A are shown (see all 2279)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144072081,2
    C,F--41786536(+) ATGACG/AAATCT 3 -- ds50012Minor allele frequency- A:0.02WA EA 238
    rs1171719221,2
    C,F--41786776(+) TTACCG/ATGCCA 3 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1388701881,2
    --41786820(+) TTGGCA/GTTTAA 3 -- ds50010--------
    rs1432307461,2
    --41787044(+) ACAGAA/GTTCTT 3 -- ut310--------
    rs1474766631,2
    --41787095(+) TACAAG/TGAGAG 3 -- ut310--------
    rs1399559161,2
    C--41787128(+) GAGCGC/TGTGAC 3 -- ut310--------
    rs115518081,2
    --41787156(+) CATCTA/TGGCAC 3 -- ut310--------
    rs1860227191,2
    --41787249(+) TAGACG/TTGGCT 3 -- ut310--------
    rs1913092561,2
    --41787260(+) TCCTTG/TGTACA 3 -- ut310--------
    rs29399831,2
    C,H--41787294(-) GTGAAT/CAGAGC 3 -- ut316Minor allele frequency- C:0.00NS EA NA 422

    HapMap Linkage Disequilibrium report for KAT6A (41786997 - 41909508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KAT6A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659867CNV Deletion23128226
    esv2445048CNV Deletion19546169
    nsv521189CNV Loss19592680
    nsv831300CNV Loss17160897
    nsv824615CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KAT6A
    DNA2.0 Custom Variant and Variant Library Synthesis for KAT6A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601408    OMIM disorders: --

    UniProtKB/Swiss-Prot: KAT6A_HUMAN, Q92794
  • Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation
    t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by
    inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which
    consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and
    disrupts its function in transcription activation
  • Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome.
    Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein

  • 15 diseases for KAT6A:    About MalaCards
    neonatal leukemia    acute monocytic leukemia    acute myeloid leukemia with t translocation    monocytic leukemia
    acute myelomonocytic leukemia    chronic myelomonocytic leukemia    prolymphocytic leukemia    leukemia
    pharyngitis    acute myeloid leukemia    acute promyelocytic leukemia    myelodysplastic syndromes
    myeloid leukemia    non-hodgkin lymphoma    hodgkin's lymphoma


    KAT6A for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for KAT6A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monocytic leukemia 86.6 11 10497217 (2), 17694082 (1), 10824998 (1), 9731070 (1) (see all 6)
    acute monocytic leukemia 86.2 5 10824998 (2), 9731070 (1), 11243405 (1)
    leukemogenesis 76.8 3 10824998 (1), 12893170 (1), 15160929 (1)
    leukemia 59.6 10 18657848 (1), 10862050 (1), 12771199 (1), 17697320 (1) (see all 10)
    chromosomal aberrations 48.4 2 14960713 (1), 12893170 (1)


    Export disorders for KAT6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KAT6A gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with KAT6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. (PubMed id 8782817)1, 2, 3, 9 Borrow J.... Housman D.E. (1996)
    2. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. (PubMed id 11742995)1, 2, 9 Kitabayashi I.... Ohki M. (2001)
    3. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (PubMed id 10824998)1, 2, 9 Chaffanet M....Pebusque M.-J. (2000)
    4. Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ. (PubMed id 12771199)1, 2, 9 Bristow C.A.P. and Shore P. (2003)
    5. MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. (PubMed id 11965546)1, 2, 9 Pelletier N.... Yang X.-J. (2002)
    6. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. (PubMed id 9558366)1, 2, 9 Carapeti M.... Cross N.C.P. (1998)
    7. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. (PubMed id 23431171)1, 2 Rokudai S....Prives C. (2013)
    8. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (2008)
    9. The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. (PubMed id 17925393)1, 2 Holbert M.A....Marmorstein R. (2007)
    10. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7994 HGNC: 13013 AceView: MYST3 Ensembl:ENSG00000083168 euGenes: HUgn7994
    ECgene: KAT6A H-InvDB: KAT6A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KAT6A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KAT6A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KAT6A gene:
    Search GeneIP for patents involving KAT6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KAT6A
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KAT6A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KAT6A  
     OriGene qSTAR qPCR primer pairs in human, mouse for KAT6A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KAT6A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KAT6A   OriGene Custom Protein Services for KAT6A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KAT6A
     QIAGEN SeqTarget long-range PCR primers for resequencing KAT6A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT6A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT6A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT6A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT6A
     GenScript Custom Purified and Recombinant Proteins Services for KAT6A GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for KAT6A
     GenScript Custom Assay Services for KAT6A GenScript Custom Superior Antibodies Services for KAT6A
     GenScript Custom overexpressing Cell Line Services for KAT6A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for KAT6A
     Search Chromatin IP Primers for KAT6A
     RT2 qPCR Primer Assay in human, mouse, rat KAT6A
     Search GNC Networks for KAT6A
     SABiosciences PCR Arrays including human, mouse, rat KAT6A
     Search Tocris compounds for KAT6A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KAT6A antibodies
     KAT6A proteins
     Antibodies for KAT6A
     See all of Abcam's Antibodies, Kits and Proteins for KAT6A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for KAT6A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT6A
     SwitchGear 3'UTR luciferase reporter plasmids for KAT6A
     SwitchGear Promoter luciferase reporter plasmids for KAT6A
     ThermoFisher Antibodies for KAT6A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT6A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KAT6A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KAT6A
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of KAT6A
     LSBio Antibodies in human, mouse, rat for KAT6A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KAT6A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4