KAT5 Gene
protein-coding GIFtS: 60
GCID: GC11P065479
|
|
K(lysine) acetyltransferase 5(Previous names: HIV-1 Tat interactive protein, 60kDa )
(Previous symbol: HTATIP)
| |
Aliases
for KAT5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| K(Lysine) Acetyltransferase 51 2 | | CPLA(2)-Interacting Protein2 3 | | HTATIP1 2 3 5 | | EC 2.3.1.483 8 | | TIP601 2 3 5 | | TIP2 | | ESA11 2 5 | | CPLA2 Interacting Protein2 | | PLIP1 2 5 | | Histone Acetyltransferase KAT52 | | HTATIP11 2 | | K-Acetyltransferase 52 | | ZC2HC51 2 | | Tat Interacting Protein, 60kDa2 | | CPLA21 | | Tip603 | | HIV-1 Tat Interactive Protein, 60kDa1 2 | | HIV-1 Tat Interactive Protein3 | | Histone Acetyltransferase HTATIP2 3 | | Lysine Acetyltransferase 53 | | 60 KDa Tat-Interactive Protein2 3 | | |
Export aliases for KAT5 gene to outside databasesPrevious GC identifers: GC11P065237 GC11P061806 |
Summaries
for KAT5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KAT5:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originallyisolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling,transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histoneacetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptionalactivation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may bothalter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins whichpositively regulate transcription. This complex may be required for the activation of transcriptional programsassociated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited tosites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tatprotein leads to KAT5 polyubiquitination and targets it to degradation
Gene Wiki entry for KAT5
|
Genomic Views
for KAT5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KAT5 gene promoter:
AP-2alpha isoform 3 STAT3 AP-2alpha isoform 2 AP-2alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KAT5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13KAT5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065479: view genomic region
(about GC identifiers)
Start:
|
65,479,467 bp from pter |
End:
|
65,487,075 bp from pter |
Size:
|
7,609 bases |
Orientation:
|
plus strand |
|
Proteins
for KAT5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993 (See
protein sequence)Recommended Name: Histone acetyltransferase KAT5 Size: 513 amino acids; 58582 Da
Subunit: Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRAand HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 andthe subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A,MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 togetherconstitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and the adenovirus E1Aprotein. Interacts with ATM. Interacts with PHF17. Interacts with HIV-1 Tat. Interacts with TRIM24 and TRIM68. Forms acomplex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1
Subcellular location: Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it isexported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclearstructures named nuclear bodies
Sequence caution: Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for KAT5:2EKO (3D)
2OU2 (3D)
Secondary accessions: B4E3C7 C9JL99 O95624 Q13430 Q17RW5 Q561W3 Q6GSE8 Q9BWK7Alternative splicing: 4 isoforms: Q92993-1 Q92993-2 Q92993-3 Q92993-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KAT5: NX_Q92993
Post-translational modifications:
Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-inducedDNA damage response, as well as its translocation to nuclear bodies1
Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. Phosphorylated form has a higher activity1
Ubiquitinated by MDM2, leading to its proteasome-dependent degradation1
Autoacetylation at Lys-327 is required for proper function (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92993
4/9 DME Specific Peptides for KAT5 (Q92993) (see all 9)
KAT5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001193762.1 NP_006379.2 NP_874368.1 NP_874369.1
ENSEMBL proteins: ENSP00000366245 ENSP00000344955 ENSP00000340330 ENSP00000434765 ENSP00000435939 ENSP00000436247 ENSP00000436000 ENSP00000436012 ENSP00000431819 ENSP00000434993 ENSP00000435766
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
KAT5 for ontologies About GeneDecksing
KAT5 Antibody Products:
Assay Products for KAT5: |
Protein
Domains /
Families
for KAT5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KAT5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92993ProtoNet protein and cluster: Q92993 2 Blocks protein families: IPB000953 Chromo domain IPB002717 MOZ/SAS-like protein
UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993Similarity: Belongs to the MYST (SAS/MOZ) familySimilarity: Contains 1 C2HC-type zinc finger |
Function
for KAT5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptionalactivation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may bothalter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins whichpositively regulate transcription. This complex may be required for the activation of transcriptional programsassociated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited tosites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tatprotein leads to KAT5 polyubiquitination and targets it to degradationCatalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]Enzyme Number (IUBMB): EC 2.3.1.481 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): KAT5 (NM_006388) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KAT5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT5 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
KAT5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KAT5:
Animal Models:
Mouse knock-out Kat5tm1Jwl for KAT5
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Kat5):
KAT5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KAT5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DNA Damage | | | 2 | Chromatin Regulation / Acetylation | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | Androgen receptor signaling pathway | | | 5 | Validated targets of C-MYC transcriptional activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KAT5
3 
Cell Signaling Technology (CST) Pathways for KAT5
5/7  BioSystems Pathways for KAT5 (see all 7)
KAT5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KAT5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/426 Interacting proteins for KAT5 (Q929931, 2, 3 ENSP000003403304) via UniProtKB, MINT, STRING, and/or I2D (see all 426)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IMP | 17360565 | | GO:0006302 | double-strand break repair |
IMP | 10966108 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
IDA | 14966270 |
KAT5 for ontologies About GeneDecksing
|
Drugs & Compounds
for KAT5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KAT5 for compounds About GeneDecksing
 Browse Tocris compounds for KAT5
2 HMDB Compounds for KAT5 About this table
2 DrugBank Compounds for KAT5 About this table
10/12 Novoseek chemical compound relationships for KAT5 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| st-pc |
83 |
9 |
11145913 (4), 18560378 (2), 7876245 (2), 20164858 (1) |
| polypropylene glycol |
65.7 |
13 |
16601686 (5), 20351180 (5), 19169279 (2) |
| lysine |
31.5 |
3 |
10096020 (2), 12110674 (1) |
| zinc |
14.9 |
9 |
11891991 (1), 17636029 (1), 11416127 (1), 12551922 (1) |
| arginine |
12.7 |
1 |
11376660 (1) |
| steroid |
0 |
2 |
11591700 (1) |
| tyrosine |
0 |
4 |
11145913 (1), 18560378 (1), 15827186 (1), 7876245 (1) |
| superoxide |
0 |
1 |
16099876 (1) |
| testosterone |
0 |
10 |
19938016 (4), 12717424 (4), 11591700 (1) |
| glutamate |
0 |
1 |
17678970 (1) |
Search CenterWatch for drugs/clinical trials and news about KAT5
|
Transcripts
for KAT5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KAT5 gene (4 alternative transcripts): NM_001206833.1 NM_006388.3 NM_182709.2 NM_182710.2 Unigene Cluster for KAT5: K(lysine) acetyltransferase 5 Hs.397010 [show with all ESTs]Unigene Representative Sequence: NM_18271017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377046(uc001ofi.3 uc001ofj.3) ENST00000352980 ENST00000341318(uc001ofk.3 uc010roo.2)
ENST00000532042 ENST00000530446 ENST00000534104 ENST00000530605 ENST00000534293
ENST00000527544 ENST00000528198 ENST00000531880 ENST00000534650(uc001ofl.3)
ENST00000525204 ENST00000534681 ENST00000533441 ENST00000525600 ENST00000533596
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): KAT5 (NM_006388) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KAT5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT5 |
Additional cDNA sequence: AB209813.1 AK130717.1 AK225100.1 AK226002.1 AK304664.1 AK313297.1 BC000166.3 BC013211.1 BC064912.1 BC093032.1 BC117167.1 BC143290.1 BC143296.1 U40989.1 U67734.1 U74667.1 24 DOTS entries: DT.447252 DT.100030490 DT.100704608 DT.101985154 DT.100846084 DT.120758723 DT.100846088 DT.120758736 DT.120758695 DT.120758725 DT.91690583 DT.100846079 DT.40106945 DT.95176156 DT.100030492 DT.120758711 DT.97794287 DT.120758712 DT.120758726 DT.75110240 DT.91836249 DT.91691437 DT.91943091 DT.95325375 24/394 AceView cDNA sequences (see all 394): BU689412 BM804760 AI436636 CB152205 CD673031 BC000166 BI835454 BM717221 CA433935 Z38411 NM_006388 BQ223038 BU164217 BG704179 AI671694 BQ045407 AI472620 BU947560 CD673906 BM699712 BE793676 NM_182710 BQ441707 BQ012850
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | |
| ExUns: | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KAT5
|
Expression
for KAT5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KAT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAAGCGGC
About this image
See KAT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KAT5
SOURCE GeneReport for Unigene cluster: Hs.397010
SABiosciences Expression via Pathway-Focused PCR Arrays including KAT5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KAT5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KAT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT5 |
Orthologs
for KAT5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KAT5 gene from 9/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KAT51 |
K(lysine) acetyltransferase 5 |
83.74(n)
97.54(a) |
|
395413 XM_003643413.1 XP_003643461.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KAT56 |
-- |
90(a) |
1 ↔ 1 |
GL344689.1(1719-10588) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.142382 |
Xenopus laevis transcribed sequences |
79.78(n) |
|
BJ617444.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cpla22 |
Transcribed sequence with strong similarity to protein more |
77.71(n) |
|
BI889237.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tip601 |
CG6121-PA |
60.66(n)
62.75(a) |
|
31362 NM_131923.3 NP_572151.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
mys-11 |
Protein MYS-1 |
53.86(n)
55.5(a) |
|
179096 NM_072395.2 NP_504796.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ESA1(YOR244W)4
ESA11 |
Catalytic subunit of the histone acetyltransferase more4
Esa1p1 |
50.33(n)1
51.48(a)1 |
|
15(792531-793868)4
8544181, 4 NP_014887.31 NP_014887.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HAM26HAM16 |
histone acetyltransferase MYST1 |
38(a)37(a) |
many ↔ manymany ↔ many |
5(3021952-3024756) 5(25828160-25830524) |
rice
(Oryza sativa) |
Liliopsida |
-- |
MYST-like histone acetyltransferase 1, putative, e... |
37(a) |
1 → many |
7(25957775-25962658) |
ENSEMBL Gene Tree for KAT5 (if available)
TreeFam Gene Tree for KAT5 (if available) |
Paralogs
for KAT5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KAT5 gene
- KAT6B2 KAT72 KAT82 KAT6A2
7 SIMAP similar genes for KAT5 using alignment to 8 protein entries: KAT5_HUMAN (see all proteins):KAT8 KAT7 KAT6A MYST3 KAT6B MYST4
DKFZp313G1618
KAT5 for paralogs About GeneDecksing
|
Genomic Variants
for KAT5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KAT5 (65479467 - 65487075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KAT5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KAT5 |
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Disorders
/ Diseases
for KAT5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KAT5 for disorders About GeneDecksing
OMIM gene information: 601409
OMIM disorders: --
20/23  diseases for KAT5 (see all 23): About MalaCardskaposi's sarcoma fanconi's anemia monocytic leukemia neurodegeneration
huntington's disease sarcoma kidney disease prostate cancer
anemia pertussis pharyngitis lung carcinoma
immunodeficiency colorectal cancer leukemia lung cancer
prostatitis retinitis carcinoma malaria
10/14 Novoseek disease relationships for KAT5 gene (see all 14) About this table
Human Genome Epidemiology (HuGE) Navigator: KAT5 (1 document)
Export disorders for KAT5 gene to outside databases
|
Publications
for KAT5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KAT5 gene, integrated from 9 sources (see all 293):
(articles sorted by number of sources associating them with KAT5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. (PubMed id 8607265)1, 2, 3, 9 Kamine J.... Chinnadurai G. (1996)
- PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. (PubMed id 11416127)1, 2, 9 Sheridan A.M.... Bonventre J.V. (2001)
- Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PubMed id 17704809)1, 2, 9 Cheng Z....Yao X. (2008)
- Tip60 is a co-repressor for STAT3. (PubMed id 12551922)1, 2, 9 Xiao H.... Yang Y.-C. (2003)
- Role of the histone acetyl transferase Tip60 in the p53 pathway. (PubMed id 15310756)1, 2, 9 Legube G.... Trouche D. (2004)
- Tip60 acetylates six lysines of a specific class in core histones in vitro. (PubMed id 10096020)1, 2, 9 Kimura A. and Horikoshi M. (1998)
- HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (PubMed id 16001085)1, 2, 9 Col E.... Khochbin S. (2005)
- Identification of a larger form of the histone acetyl transferase Tip60. (PubMed id 12801643)1, 2, 9 Legube G. and Trouche D. (2003)
- Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. (PubMed id 11927554)1, 2, 9 Legube G....Trouche D. (2002)
- Tip60 acetyltransferase activity is controlled by phosphorylation. (PubMed id 12468530)1, 2, 9 Lemercier C....Khochbin S. (2003)
|
External Searches for KAT5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KAT5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KAT5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KAT5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KAT5 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/htatip/ |
|
| | |
About This Section
| Patent Information for KAT5 gene:
Search GeneIP for patents involving KAT5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KAT5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KAT5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KAT5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KAT5 | | | OriGene Protein Over-expression Lysate for KAT5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KAT5 | | OriGene 3'-UTR Clone for KAT5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KAT5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KAT5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KAT5 | | OriGene Custom Protein Services for KAT5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KAT5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KAT5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT5 |
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