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Aliases for KAT5 Gene

Aliases for KAT5 Gene

  • K(Lysine) Acetyltransferase 5 2 3
  • HIV-1 Tat Interactive Protein, 60kDa 2 3
  • Histone Acetyltransferase HTATIP 3 4
  • 60 KDa Tat-Interactive Protein 3 4
  • CPLA(2)-Interacting Protein 3 4
  • K-Acetyltransferase 5 2 3
  • EC 2.3.1.48 4 63
  • HTATIP 3 4
  • TIP60 3 4
  • Tat Interacting Protein, 60kDa 3
  • HIV-1 Tat Interactive Protein 4
  • Lysine Acetyltransferase 5 4
  • CPLA2 Interacting Protein 3
  • Tat Interacting Protein 2
  • HTATIP1 3
  • ZC2HC5 3
  • CPLA2 3
  • 60kDa 2
  • ESA1 3
  • PLIP 3
  • TIP 3

External Ids for KAT5 Gene

Previous HGNC Symbols for KAT5 Gene

  • HTATIP

Previous GeneCards Identifiers for KAT5 Gene

  • GC11P065237
  • GC11P065479
  • GC11P061806

Summaries for KAT5 Gene

Entrez Gene Summary for KAT5 Gene

  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT5 Gene

KAT5 (K(Lysine) Acetyltransferase 5) is a Protein Coding gene. Diseases associated with KAT5 include ipex syndrome and hiv-1. Among its related pathways are Signaling by GPCR and Cell Cycle, Mitotic. GO annotations related to this gene include transcription factor binding and protein complex binding. An important paralog of this gene is KAT8.

UniProtKB/Swiss-Prot for KAT5 Gene

  • Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Gene Wiki entry for KAT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT5 Gene

Genomics for KAT5 Gene

Regulatory Elements for KAT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KAT5 Gene

Chromosome:
11
Start:
65,711,996 bp from pter
End:
65,719,606 bp from pter
Size:
7,611 bases
Orientation:
Plus strand

Genomic View for KAT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT5 Gene

Proteins for KAT5 Gene

  • Protein details for KAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92993-KAT5_HUMAN
    Recommended name:
    Histone acetyltransferase KAT5
    Protein Accession:
    Q92993
    Secondary Accessions:
    • B4E3C7
    • C9JL99
    • O95624
    • Q13430
    • Q17RW5
    • Q561W3
    • Q6GSE8
    • Q9BWK7

    Protein attributes for KAT5 Gene

    Size:
    513 amino acids
    Molecular mass:
    58582 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Interacts with ATM. Interacts with JADE1. Interacts with HIV-1 Tat. Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex. Interacts with FOXP3. Interacts with ZBTB49 (PubMed:25245946).
    SequenceCaution:
    • Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT5 Gene

    Alternative splice isoforms for KAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT5 Gene

Proteomics data for KAT5 Gene at MOPED

Selected DME Specific Peptides for KAT5 Gene

Post-translational modifications for KAT5 Gene

  • Autoacetylation at Lys-327 is required for proper function.
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity.
  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • Ubiquitination at Lys 230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT5 (Tip60)

Domains & Families for KAT5 Gene

Suggested Antigen Peptide Sequences for KAT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q92993

UniProtKB/Swiss-Prot:

KAT5_HUMAN :
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
  • Belongs to the MYST (SAS/MOZ) family.
  • Contains 1 C2HC-type zinc finger.
Domain:
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with KAT5: view

Function for KAT5 Gene

Molecular function for KAT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Enzyme Numbers (IUBMB) for KAT5 Gene

Gene Ontology (GO) - Molecular Function for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 17360565
GO:0004402 histone acetyltransferase activity IMP 17996965
GO:0005515 protein binding IPI 15383276
GO:0016407 acetyltransferase activity TAS --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with KAT5: view
genes like me logo Genes that share phenotypes with KAT5: view

Animal Models for KAT5 Gene

MGI Knock Outs for KAT5:

Animal Model Products

miRNA for KAT5 Gene

miRTarBase miRNAs that target KAT5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for KAT5 Gene

Localization for KAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT5 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT5 Gene COMPARTMENTS Subcellular localization image for KAT5 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA 17996965
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA 16387653
genes like me logo Genes that share ontologies with KAT5: view

Pathways & Interactions for KAT5 Gene

genes like me logo Genes that share pathways with KAT5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for KAT5 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17360565
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
genes like me logo Genes that share ontologies with KAT5: view

Drugs & Compounds for KAT5 Gene

(13) Drugs for KAT5 Gene - From: NovoSeek, DGIdb, HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Zinc Approved Pharma 1404
S-Acetyl-Cysteine Experimental Pharma Target 0
Coenzyme A Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0

(6) Additional Compounds for KAT5 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
glutamate
Polypropylene glycol
Steroid
ST-PC
genes like me logo Genes that share compounds with KAT5: view

Transcripts for KAT5 Gene

Unigene Clusters for KAT5 Gene

K(lysine) acetyltransferase 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14:

ExUns: 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KAT5 Gene

GeneLoc Exon Structure for
KAT5
ECgene alternative splicing isoforms for
KAT5

Expression for KAT5 Gene

mRNA expression in normal human tissues for KAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.9) and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT5 Gene



SOURCE GeneReport for Unigene cluster for KAT5 Gene Hs.397010

genes like me logo Genes that share expression patterns with KAT5: view

Protein tissue co-expression partners for KAT5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KAT5 Gene

Orthologs for KAT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KAT5 35
  • 93.11 (n)
  • 98.83 (a)
KAT5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT5 35
  • 94.81 (n)
  • 99.45 (a)
KAT5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat5 35
  • 91.29 (n)
  • 99.03 (a)
Kat5 16
Kat5 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KAT5 35
  • 99.03 (n)
  • 99.22 (a)
KAT5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat5 35
  • 90.97 (n)
  • 99.03 (a)
oppossum
(Monodelphis domestica)
Mammalia KAT5 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves KAT5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT5 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat5 35
  • 76.91 (n)
  • 90.47 (a)
Str.10748 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14238 35
zebrafish
(Danio rerio)
Actinopterygii cpla2 35
htatip 35
  • 71.71 (n)
  • 83.07 (a)
htatip 36
  • 79 (a)
OneToMany
KAT5 (1 of 2) 36
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3592 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001539 35
  • 66.51 (n)
  • 70.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tip60 35
  • 60.73 (n)
  • 62.75 (a)
Tip60 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mys-1 35
  • 53.79 (n)
  • 55.5 (a)
mys-1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR138W 35
  • 56.86 (n)
  • 55.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11209g 35
  • 52.64 (n)
  • 52.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 35
  • 50.41 (n)
  • 51.48 (a)
ESA1 36
  • 43 (a)
OneToMany
ESA1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1105 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05218 35
  • 54.37 (n)
  • 47.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mst1 35
  • 49.48 (n)
  • 48.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1513 36
  • 59 (a)
OneToOne
Species with no ortholog for KAT5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT5 Gene

ENSEMBL:
Gene Tree for KAT5 (if available)
TreeFam:
Gene Tree for KAT5 (if available)

Paralogs for KAT5 Gene

Paralogs for KAT5 Gene

genes like me logo Genes that share paralogs with KAT5: view

Variants for KAT5 Gene

Sequence variations from dbSNP and Humsavar for KAT5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs487264 -- 65,713,994(+) AACAT(G/T)GTTCA intron-variant
rs488170 -- 65,714,073(+) GCTGG(C/T)GGATC intron-variant
rs551115 -- 65,713,320(+) CCCCA(A/G)AGGAA intron-variant, splice-acceptor-variant
rs563427 -- 65,717,098(+) GGGGA(A/G)CCAGC intron-variant
rs573589 -- 65,716,510(+) AGCTG(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT5 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897723 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
nsv897755 CNV Gain 21882294

Variation tolerance for KAT5 Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT5 Gene

HapMap Linkage Disequilibrium report
KAT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT5 Gene

Disorders for KAT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KAT5 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
ipex syndrome
  • immunodeficiency
hiv-1
  • aids, slow progression to
- elite association
Search KAT5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KAT5

Human Genome Epidemiology (HuGE) Navigator
KAT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT5
genes like me logo Genes that share disorders with KAT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT5 Gene

Publications for KAT5 Gene

  1. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. (PMID: 8607265) Kamine J. … Chinnadurai G. (Virology 1996) 2 23 67
  2. Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. (PMID: 20070254) Chailleux C. … Trouche D. (Biochem. J. 2010) 23 67
  3. Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus. (PMID: 19938016) Shiota M. … Naito S. (Prostate 2010) 23 67
  4. Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation. (PMID: 20144237) Kobayashi J. … Komatsu K. (Mol. Cancer 2010) 23 67
  5. Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells. (PMID: 20164858) Toptan T. … Fickenscher H. (Gene Ther. 2010) 23 67

Products for KAT5 Gene

  • Addgene plasmids for KAT5

Sources for KAT5 Gene

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