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Aliases for KAT5 Gene

Aliases for KAT5 Gene

  • Lysine Acetyltransferase 5 2 3 4 5
  • HIV-1 Tat Interactive Protein, 60kDa 2 3
  • Histone Acetyltransferase HTATIP 3 4
  • Tat Interacting Protein, 60kDa 2 3
  • 60 KDa Tat-Interactive Protein 3 4
  • K(Lysine) Acetyltransferase 5 2 3
  • CPLA(2)-Interacting Protein 3 4
  • K-Acetyltransferase 5 2 3
  • EC 2.3.1.48 4 58
  • HTATIP 3 4
  • TIP60 3 4
  • Histone Acetyltransferase KAT5 3
  • HIV-1 Tat Interactive Protein 4
  • CPLA2 Interacting Protein 3
  • HTATIP1 3
  • ZC2HC5 3
  • CPLA2 3
  • ESA1 3
  • PLIP 3
  • TIP 3

External Ids for KAT5 Gene

Previous HGNC Symbols for KAT5 Gene

  • HTATIP

Previous GeneCards Identifiers for KAT5 Gene

  • GC11P065237
  • GC11P065479
  • GC11P061806

Summaries for KAT5 Gene

Entrez Gene Summary for KAT5 Gene

  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT5 Gene

KAT5 (Lysine Acetyltransferase 5) is a Protein Coding gene. Diseases associated with KAT5 include Hiv-1. Among its related pathways are DNA Damage and DNA Double Strand Break Response. GO annotations related to this gene include transcription factor binding and protein complex binding. An important paralog of this gene is KAT6A.

UniProtKB/Swiss-Prot for KAT5 Gene

  • Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Gene Wiki entry for KAT5 Gene

Additional gene information for KAT5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT5 Gene

Genomics for KAT5 Gene

Regulatory Elements for KAT5 Gene

Enhancers for KAT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 123 -221.9 -221913 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 101.9 -287.8 -287815 18 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 51.1 +183.5 183463 18 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
GH11H065851 1.4 ENCODE dbSUPER 69.2 +145.5 145489 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SART1 ENSG00000258297 RBM14 EIF1AD KAT5 POLA2 PCNX3 ZFPL1 SF3B2 SNX32
GH11H066001 1.2 ENCODE 44.2 +290.4 290417 2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A PPARGC1A MEF2D ZNF610 ZFPL1 ENSG00000258297 SF3B2 SART1 KAT5 EIF1AD ENSG00000255320 PCNX3 RBM14 POLA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KAT5 on UCSC Golden Path with GeneCards custom track

Promoters for KAT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040879 104 1401 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610

Genomic Location for KAT5 Gene

Chromosome:
11
Start:
65,711,996 bp from pter
End:
65,719,606 bp from pter
Size:
7,611 bases
Orientation:
Plus strand

Genomic View for KAT5 Gene

Genes around KAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT5 Gene

Proteins for KAT5 Gene

  • Protein details for KAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92993-KAT5_HUMAN
    Recommended name:
    Histone acetyltransferase KAT5
    Protein Accession:
    Q92993
    Secondary Accessions:
    • B4E3C7
    • C9JL99
    • O95624
    • Q13430
    • Q17RW5
    • Q561W3
    • Q6GSE8
    • Q9BWK7

    Protein attributes for KAT5 Gene

    Size:
    513 amino acids
    Molecular mass:
    58582 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Interacts with ATM. Interacts with JADE1. Interacts with HIV-1 Tat. Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex. Interacts with FOXP3. Interacts with ZBTB49 (PubMed:25245946).
    SequenceCaution:
    • Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT5 Gene

    Alternative splice isoforms for KAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT5 Gene

Selected DME Specific Peptides for KAT5 Gene

Q92993:
  • FSYELSK
  • WYFSPYP
  • LLIEFSY
  • VGYFSKEK
  • PLSDLGL
  • PPYQRRG
  • FNKRLDEW
  • ACILTLP
  • SFFEIDGR

Post-translational modifications for KAT5 Gene

  • Autoacetylation at Lys-327 is required for proper function.
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity.
  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • Ubiquitination at isoforms=2, 3, 4230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT5 (Tip60)

Domains & Families for KAT5 Gene

Gene Families for KAT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for KAT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q92993

UniProtKB/Swiss-Prot:

KAT5_HUMAN :
  • Belongs to the MYST (SAS/MOZ) family.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
genes like me logo Genes that share domains with KAT5: view

Function for KAT5 Gene

Molecular function for KAT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Enzyme Numbers (IUBMB) for KAT5 Gene

Phenotypes From GWAS Catalog for KAT5 Gene

Gene Ontology (GO) - Molecular Function for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 17360565
GO:0004402 histone acetyltransferase activity IEA,IMP 17996965
GO:0005515 protein binding IPI 10364196
GO:0016407 acetyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with KAT5: view
genes like me logo Genes that share phenotypes with KAT5: view

Animal Models for KAT5 Gene

MGI Knock Outs for KAT5:

Animal Model Products

  • Taconic Biosciences Mouse Models for KAT5

CRISPR Products

miRNA for KAT5 Gene

miRTarBase miRNAs that target KAT5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT5
  • Applied Biological Materials Clones for KAT5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT5 Gene

Localization for KAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT5 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IEA,IDA 17996965
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA,IEA 16387653
genes like me logo Genes that share ontologies with KAT5: view

Pathways & Interactions for KAT5 Gene

genes like me logo Genes that share pathways with KAT5: view

Pathways by source for KAT5 Gene

SIGNOR curated interactions for KAT5 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17360565
GO:0000729 DNA double-strand break processing TAS --
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0006260 DNA replication TAS --
genes like me logo Genes that share ontologies with KAT5: view

Drugs & Compounds for KAT5 Gene

(15) Drugs for KAT5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Acetyl-Cysteine Experimental Pharma Target 0
Coenzyme A Nutra Target 0
Anacardic acid Pharma HAT inhibitor, Noncompetitive PCAF/p300 inhibitor 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0

(6) Additional Compounds for KAT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(5) ApexBio Compounds for KAT5 Gene

Compound Action Cas Number
Anacardic acid HAT inhibitor 16611-84-0
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
NU 9056 KAT5 (Tip60) HAT inhibitor
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT5: view

Drug Products

Transcripts for KAT5 Gene

Unigene Clusters for KAT5 Gene

K(lysine) acetyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT5
  • Applied Biological Materials Clones for KAT5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14:

ExUns: 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KAT5 Gene

GeneLoc Exon Structure for
KAT5
ECgene alternative splicing isoforms for
KAT5

Expression for KAT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.9) and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT5 Gene



Protein tissue co-expression partners for KAT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KAT5 Gene:

KAT5

SOURCE GeneReport for Unigene cluster for KAT5 Gene:

Hs.397010

Evidence on tissue expression from TISSUES for KAT5 Gene

  • Blood(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
  • Thyroid gland(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with KAT5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT5 Gene

Orthologs for KAT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT5 33 34
  • 99.03 (n)
oppossum
(Monodelphis domestica)
Mammalia KAT5 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT5 33 34
  • 94.81 (n)
cow
(Bos Taurus)
Mammalia KAT5 33 34
  • 93.11 (n)
mouse
(Mus musculus)
Mammalia Kat5 33 16 34
  • 91.29 (n)
rat
(Rattus norvegicus)
Mammalia Kat5 33
  • 90.97 (n)
chicken
(Gallus gallus)
Aves KAT5 34
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT5 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat5 33
  • 76.91 (n)
Str.10748 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14238 33
zebrafish
(Danio rerio)
Actinopterygii KAT5 (1 of 2) 34
  • 77 (a)
OneToMany
htatip 33 34
  • 71.71 (n)
cpla2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3592 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001539 33
  • 66.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tip60 33 34
  • 60.73 (n)
worm
(Caenorhabditis elegans)
Secernentea mys-1 33 34
  • 53.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR138W 33
  • 56.86 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11209g 33
  • 52.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 33 34 36
  • 50.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1513 34
  • 59 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU05218 33
  • 54.37 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mst1 33
  • 49.48 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1105 33
Species where no ortholog for KAT5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT5 Gene

ENSEMBL:
Gene Tree for KAT5 (if available)
TreeFam:
Gene Tree for KAT5 (if available)

Paralogs for KAT5 Gene

Paralogs for KAT5 Gene

genes like me logo Genes that share paralogs with KAT5: view

Variants for KAT5 Gene

Sequence variations from dbSNP and Humsavar for KAT5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs75146158 Pathogenic 65,720,085(-) TGCCA(A/T)AGTGC downstream-variant-500B, reference, missense
rs771013055 Likely pathogenic 65,719,800(+) CACCT(A/G/T)TGCGT downstream-variant-500B, reference, missense
rs142614068 Likely benign 65,718,834(+) CAGAT(-/A)AAAGG intron-variant, utr-variant-3-prime
rs373799308 Likely benign 65,718,162(+) CCAGC(C/T)AGGAG intron-variant, utr-variant-3-prime
rs4645934 Likely benign 65,717,686(+) CATTC(A/G)AGAAA