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Aliases for KAT5 Gene

Aliases for KAT5 Gene

  • K(Lysine) Acetyltransferase 5 2 3
  • HTATIP 3 4 6
  • TIP60 3 4 6
  • HIV-1 Tat Interactive Protein, 60kDa 2 3
  • Histone Acetyltransferase HTATIP 3 4
  • 60 KDa Tat-Interactive Protein 3 4
  • CPLA(2)-Interacting Protein 3 4
  • K-Acetyltransferase 5 2 3
  • EC 2.3.1.48 4 63
  • ESA1 3 6
  • PLIP 3 6
  • Tat Interacting Protein, 60kDa 3
  • Histone Acetyltransferase KAT5 3
  • HIV-1 Tat Interactive Protein 4
  • Lysine Acetyltransferase 5 4
  • CPLA2 Interacting Protein 3
  • Tat Interacting Protein 2
  • HTATIP1 3
  • ZC2HC5 3
  • CPLA2 3
  • 60kDa 2
  • TIP 3

External Ids for KAT5 Gene

Previous HGNC Symbols for KAT5 Gene

  • HTATIP

Previous GeneCards Identifiers for KAT5 Gene

  • GC11P065237
  • GC11P065479
  • GC11P061806

Summaries for KAT5 Gene

Entrez Gene Summary for KAT5 Gene

  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT5 Gene

KAT5 (K(Lysine) Acetyltransferase 5) is a Protein Coding gene. Diseases associated with KAT5 include hiv-1. Among its related pathways are Cell Cycle / Checkpoint Control and ATF-2 transcription factor network. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is KAT8.

UniProtKB/Swiss-Prot for KAT5 Gene

  • Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Gene Wiki entry for KAT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT5 Gene

Genomics for KAT5 Gene

Regulatory Elements for KAT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KAT5 Gene

Start:
65,711,996 bp from pter
End:
65,719,606 bp from pter
Size:
7,611 bases
Orientation:
Plus strand

Genomic View for KAT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT5 Gene

Proteins for KAT5 Gene

  • Protein details for KAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92993-KAT5_HUMAN
    Recommended name:
    Histone acetyltransferase KAT5
    Protein Accession:
    Q92993
    Secondary Accessions:
    • B4E3C7
    • C9JL99
    • O95624
    • Q13430
    • Q17RW5
    • Q561W3
    • Q6GSE8
    • Q9BWK7

    Protein attributes for KAT5 Gene

    Size:
    513 amino acids
    Molecular mass:
    58582 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Interacts with ATM. Interacts with JADE1. Interacts with HIV-1 Tat. Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex. Interacts with FOXP3. Interacts with ZBTB49 (PubMed:25245946).
    SequenceCaution:
    • Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT5 Gene

    Alternative splice isoforms for KAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT5 Gene

Proteomics data for KAT5 Gene at MOPED

Selected DME Specific Peptides for KAT5 Gene

Post-translational modifications for KAT5 Gene

  • Autoacetylation at Lys-327 is required for proper function.
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity.
  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT5 (Tip60)

Domains for KAT5 Gene

Gene Families for KAT5 Gene

HGNC:
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases
  • ZC2HC :Zinc fingers, C2HC-type containing

Suggested Antigen Peptide Sequences for KAT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q92993

UniProtKB/Swiss-Prot:

KAT5_HUMAN :
  • Q92993
Domain:
  • Contains 1 MYST-type HAT (histone acetyltransferase) domain.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with KAT5: view

Function for KAT5 Gene

Molecular function for KAT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Enzyme Numbers (IUBMB) for KAT5 Gene

Gene Ontology (GO) - Molecular Function for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 17360565
GO:0004402 histone acetyltransferase activity IMP 17996965
GO:0005515 protein binding IPI 15383276
GO:0008134 transcription factor binding --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with KAT5: view
genes like me logo Genes that share phenotypes with KAT5: view

Animal Models for KAT5 Gene

MGI Knock Outs for KAT5:

Animal Model Products

CRISPR Products

miRNA for KAT5 Gene

miRTarBase miRNAs that target KAT5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for KAT5 Gene

Localization for KAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT5 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT5 Gene COMPARTMENTS Subcellular localization image for KAT5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin --
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA 17996965
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with KAT5: view

Pathways for KAT5 Gene

genes like me logo Genes that share pathways with KAT5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17360565
GO:0006302 double-strand break repair IMP 10966108
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with KAT5: view

Compounds for KAT5 Gene

(2) HMDB Compounds for KAT5 Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(2) Drugbank Compounds for KAT5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Coenzyme A
85-61-0 target
S-Acetyl-Cysteine
target

(12) Novoseek inferred chemical compound relationships for KAT5 Gene

Compound -log(P) Hits PubMed IDs
st-pc 83 9
polypropylene glycol 65.7 12
lysine 31.5 3
zinc 14.9 4
arginine 12.7 1
genes like me logo Genes that share compounds with KAT5: view

Transcripts for KAT5 Gene

Unigene Clusters for KAT5 Gene

K(lysine) acetyltransferase 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14:

ExUns: 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KAT5 Gene

GeneLoc Exon Structure for
KAT5
ECgene alternative splicing isoforms for
KAT5

Expression for KAT5 Gene

mRNA expression in normal human tissues for KAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT5 Gene

SOURCE GeneReport for Unigene cluster for KAT5 Gene Hs.397010

genes like me logo Genes that share expressions with KAT5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KAT5 Gene

Orthologs for KAT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT5 35
  • 99.03 (n)
  • 99.22 (a)
KAT5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KAT5 35
  • 93.11 (n)
  • 98.83 (a)
KAT5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT5 35
  • 94.81 (n)
  • 99.45 (a)
KAT5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat5 35
  • 91.29 (n)
  • 99.03 (a)
Kat5 16
Kat5 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KAT5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat5 35
  • 90.97 (n)
  • 99.03 (a)
chicken
(Gallus gallus)
Aves KAT5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT5 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14238 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kat5 35
  • 76.91 (n)
  • 90.47 (a)
Str.10748 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3592 35
zebrafish
(Danio rerio)
Actinopterygii cpla2 35
htatip 35
  • 71.71 (n)
  • 83.07 (a)
htatip 36
  • 79 (a)
OneToMany
KAT5 (1 of 2) 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001539 35
  • 66.51 (n)
  • 70.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tip60 35
  • 60.73 (n)
  • 62.75 (a)
Tip60 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mys-1 35
  • 53.79 (n)
  • 55.5 (a)
mys-1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR138W 35
  • 56.86 (n)
  • 55.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 35
  • 50.41 (n)
  • 51.48 (a)
ESA1 36
  • 43 (a)
OneToMany
ESA1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11209g 35
  • 52.64 (n)
  • 52.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05218 35
  • 54.37 (n)
  • 47.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mst1 35
  • 49.48 (n)
  • 48.19 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1105 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1513 36
  • 59 (a)
OneToOne
Species with no ortholog for KAT5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT5 Gene

ENSEMBL:
Gene Tree for KAT5 (if available)
TreeFam:
Gene Tree for KAT5 (if available)

Paralogs for KAT5 Gene

Paralogs for KAT5 Gene

Selected SIMAP similar genes for KAT5 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with KAT5: view

Variants for KAT5 Gene

Sequence variations from dbSNP and Humsavar for KAT5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs487264 -- 65,713,994(+) AACAT(G/T)GTTCA intron-variant
rs488170 -- 65,714,073(+) GCTGG(C/T)GGATC intron-variant
rs551115 -- 65,713,320(+) CCCCA(A/G)AGGAA intron-variant, splice-acceptor-variant
rs563427 -- 65,717,098(+) GGGGA(A/G)CCAGC intron-variant
rs573589 -- 65,716,510(+) AGCTG(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT5 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897723 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
nsv897755 CNV Gain 21882294

Relevant External Links for KAT5 Gene

HapMap Linkage Disequilibrium report
KAT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT5 Gene

Disorders for KAT5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KAT5 Gene including...

Search for KAT5 Gene in MalaCards »

(14) Novoseek inferred disease relationships for KAT5 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 68.2 22
leukemogenesis 37.8 1
aids 22.2 2
kaposi sarcoma 22.2 1
prostate cancer 13.7 5

Relevant External Links for KAT5

Human Genome Epidemiology (HuGE) Navigator
KAT5
genes like me logo Genes that share disorders with KAT5: view

No data available for UniProtKB/Swiss-Prot for KAT5 Gene

Publications for KAT5 Gene

  1. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. (PMID: 8607265) Kamine J. … Chinnadurai G. (Virology 1996) 2 3 4 23
  2. Tip60 acetylates six lysines of a specific class in core histones in vitro. (PMID: 10096020) Kimura A. … Horikoshi M. (Genes Cells 1998) 3 4 23
  3. PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. (PMID: 11416127) Sheridan A.M. … Bonventre J.V. (Mol. Cell. Biol. 2001) 3 4 23
  4. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. (PMID: 11927554) Legube G. … Trouche D. (EMBO J. 2002) 3 4 23
  5. Tip60 is a co-repressor for STAT3. (PMID: 12551922) Xiao H. … Yang Y.-C. (J. Biol. Chem. 2003) 3 4 23

Products for KAT5 Gene

  • Addgene plasmids for KAT5

Sources for KAT5 Gene

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