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KAT5 Gene

protein-coding   GIFtS: 65
GCID: GC11P065479

K(Lysine) Acetyltransferase 5

(Previous names: HIV-1 Tat interactive protein, 60kDa)
(Previous symbol: HTATIP)
  See KAT5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
K(Lysine) Acetyltransferase 51 2     Tat Interacting Protein1
HTATIP1 2 3 5     HTATIP12
TIP602 3 5     TIP2
HIV-1 Tat Interactive Protein, 60kDa1 2     ZC2HC52
K-Acetyltransferase 51 2     cPLA22
Histone Acetyltransferase HTATIP2 3     CPLA2 Interacting Protein2
60 KDa Tat-Interactive Protein2 3     Histone Acetyltransferase KAT52
CPLA(2)-Interacting Protein2 3     Tat Interacting Protein, 60kDa2
EC 2.3.1.483 8     Tip603
ESA12 5     HIV-1 Tat Interactive Protein3
PLIP2 5     Lysine Acetyltransferase 53
60kDa1     

External Ids:    HGNC: 52751   Entrez Gene: 105242   Ensembl: ENSG000001729777   OMIM: 6014095   UniProtKB: Q929933   

Export aliases for KAT5 gene to outside databases

Previous GC identifers: GC11P065237 GC11P061806


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KAT5 Gene:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was
originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin
remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This
protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important
role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KAT5 Gene:
KAT5 (K(lysine) acetyltransferase 5) is a protein-coding gene. Diseases associated with KAT5 include hiv-1, and kaposi's sarcoma. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993
Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional
activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. This complex may be required for the activation of transcriptional programs
associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that
specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection,
interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves
NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2

Gene Wiki entry for KAT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KAT5 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): KAT5 promoter sequence
   Search Chromatin IP Primers for KAT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KAT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

KAT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065479:  view genomic region     (about GC identifiers)

Start:
65,479,467 bp from pter      End:
65,487,077 bp from pter
Size:
7,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT5  
Size: 513 amino acids; 58582 Da
Subunit: Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2,
EDNRA and HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit
KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3,
actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1,
and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and
the adenovirus E1A protein. Interacts with ATM. Interacts with JADE1. Interacts with HIV-1 Tat. Interacts with
TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex
with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex
Sequence caution: Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for KAT5:
2EKO (3D)        2OU2 (3D)    
Secondary accessions: B4E3C7 C9JL99 O95624 Q13430 Q17RW5 Q561W3 Q6GSE8 Q9BWK7
Alternative splicing: 4 isoforms:  Q92993-1   Q92993-2   Q92993-3   Q92993-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KAT5: NX_Q92993

Explore proteomics data for KAT5 at MOPED

Post-translational modifications: 

  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in
    UV-induced DNA damage response, as well as its translocation to nuclear bodies1
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. Phosphorylated form has a higher activity1
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation1
  • Autoacetylation at Lys-327 is required for proper function (By similarity)1
  • Ubiquitination2 at Lys230
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KAT5 (Q92993) (see all 9)
     LLIEFSY  ACILTLP  FSYELSK  WYFSPYP 


    See KAT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193762.1  NP_006379.2  NP_874368.1  NP_874369.1  

    ENSEMBL proteins: 
     ENSP00000366245   ENSP00000344955   ENSP00000340330   ENSP00000434765   ENSP00000435939  
     ENSP00000436247   ENSP00000436000   ENSP00000436012   ENSP00000431819   ENSP00000434993  
     ENSP00000435766  
    Reactome Protein details: Q92993

    KAT5 Human Recombinant Protein Products:

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    Novus Biologicals KAT5 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for KAT5

     
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    antibodies-online proteins for KAT5 (6 products) 

     
    antibodies-online peptides for KAT5

    KAT5 Antibody Products:

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    antibodies-online antibodies for KAT5 (122 products) 

    KAT5 Assay Products:

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    Cloud-Clone Corp. ELISAs for KAT5
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002717 MOZ_SAS
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92993

    ProtoNet protein and cluster: Q92993

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB002717 MOZ/SAS-like protein


    UniProtKB/Swiss-Prot: KAT5_HUMAN, Q92993
    Similarity: Belongs to the MYST (SAS/MOZ) family
    Similarity: Contains 1 C2HC-type zinc finger


    Find genes that share domains with KAT5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT5_HUMAN, Q92993
    Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional
    activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
    both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. This complex may be required for the activation of transcriptional programs
    associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
    and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
    recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that
    specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection,
    interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves
    NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS17360565
    GO:0004402histone acetyltransferase activity IMP17996965
    GO:0005515protein binding IPI15383276
    GO:0008134transcription factor binding ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with KAT5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KAT5:
     Decreased DCP1a protein expres  Prevent p53-dependent growth a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kat5):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    Find genes that share phenotypes with KAT5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kat5tm1Jwl for KAT5

       genOway: Develop your customized and physiologically relevant rodent model for KAT5

    miRNA
    Products:
        
    miRTarBase miRNAs that target KAT5:
    hsa-mir-766-3p (MIRT039033)

    Block miRNA regulation of human, mouse, rat KAT5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate KAT5:
    hsa-miR-22 hsa-miR-137 hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidKAT5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KAT5

    Gene Editing
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    Sino Biological Human cDNA Clone for KAT5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT5
    Addgene plasmids for KAT5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAT5_HUMAN, Q92993: Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1,
    it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate
    subnuclear structures named nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0000812Swr1 complex IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with KAT5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KAT5 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathway0.42
    4Packaging Of Telomere Ends
    Histone modification0.31
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    Find genes that share SuperPaths with KAT5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for KAT5
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control
    DNA Damage

    Selected BioSystems Pathways for KAT5 (see all 7)
        Androgen receptor signaling pathway
    IL-9 Signaling Pathway
    ATF-2 transcription factor network
    Regulation of Androgen receptor activity
    p53 pathway


    2 Reactome Pathways for KAT5
        HATs acetylate histones
    formation of the beta-catenin:TCF transactivating complex


    1 Kegg Pathway  (Kegg details for KAT5):
        HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT5: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KAT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KAT5 (Q929931, 2, 3 ENSP000003403304) via UniProtKB, MINT, STRING, and/or I2D (see all 493)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=6 STRING: ENSP00000352980
    HIST1H4FP628053, ENSP000003669744I2D: score=6 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=6 STRING: ENSP00000289352
    HIST1H4BP628053I2D: score=6 
    HIST1H4CP628053I2D: score=6 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP17360565
    GO:0006302double-strand break repair IMP10966108
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with KAT5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KAT5

    2 HMDB Compounds for KAT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    2 DrugBank Compounds for KAT5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coenzyme A-- 85-61-0target--17139284 17016423 10592235
    S-Acetyl-Cysteine-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for KAT5 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    st-pc 83 9 11145913 (4), 18560378 (2), 7876245 (2), 20164858 (1)
    polypropylene glycol 65.7 13 16601686 (5), 20351180 (5), 19169279 (2)
    lysine 31.5 3 10096020 (2), 12110674 (1)
    zinc 14.9 9 11891991 (1), 17636029 (1), 11416127 (1), 12551922 (1)
    arginine 12.7 1 11376660 (1)
    steroid 0 2 11591700 (1)
    tyrosine 0 4 11145913 (1), 18560378 (1), 15827186 (1), 7876245 (1)
    superoxide 0 1 16099876 (1)
    testosterone 0 10 19938016 (4), 12717424 (4), 11591700 (1)
    glutamate 0 1 17678970 (1)



    Find genes that share compounds with KAT5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KAT5 gene (4 alternative transcripts): 
    NM_001206833.1  NM_006388.3  NM_182709.2  NM_182710.2  

    Unigene Cluster for KAT5:

    K(lysine) acetyltransferase 5
    Hs.397010  [show with all ESTs]
    Unigene Representative Sequence: NM_182710
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377046(uc001ofi.3 uc001ofj.3) ENST00000352980 ENST00000341318(uc001ofk.3 uc010roo.2)
    ENST00000532042 ENST00000530446 ENST00000534104 ENST00000530605 ENST00000534293
    ENST00000527544 ENST00000528198 ENST00000531880 ENST00000534650(uc001ofl.3)
    ENST00000525204 ENST00000534681 ENST00000533441 ENST00000525600 ENST00000533596

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    SwitchGear 3'UTR luciferase reporter plasmidKAT5 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat KAT5

    Additional mRNA sequence: 

    AB209813.1 AK130717.1 AK225100.1 AK226002.1 AK304664.1 AK313297.1 BC000166.3 BC013211.1 
    BC064912.1 BC093032.1 BC117167.1 BC143290.1 BC143296.1 U40989.1 U67734.1 U74667.1 

    24 DOTS entries:

    DT.447252  DT.100030490  DT.100704608  DT.101985154  DT.100846084  DT.120758723  DT.100846088  DT.120758736 
    DT.120758695  DT.120758725  DT.91690583  DT.100846079  DT.40106945  DT.95176156  DT.100030492  DT.120758711 
    DT.97794287  DT.120758712  DT.120758726  DT.75110240  DT.91836249  DT.91691437  DT.91943091  DT.95325375 

    Selected AceView cDNA sequences (see all 394):

    CD673031 BC000166 BU161249 AA190556 AI423694 BI915675 BF376777 CF130050 
    CF127290 CA306885 BU947560 CR611711 Z38411 BI835454 AI436636 BQ673514 
    AI033408 AI283210 BQ045407 AA356423 BM697770 BC013211 AI192270 AI671694 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a ·
    SP1:                          -     -     -                       -     -     -     -                                                                           
    SP2:                          -     -     -                       -     -     -     -                                                                       -   
    SP3:                          -     -     -                       -     -                                                                                       
    SP4:                                -     -                       -     -                                                                                       
    SP5:                                                              -     -     -     -                                                                       -   

    ExUns: 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for KAT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KAT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAAGCGGC
    KAT5 Expression
    About this image


    KAT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    KAT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KAT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.397010
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT5: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KAT5 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat51 , 5 K(lysine) acetyltransferase 51, 5 91.29(n)1
    99.03(a)1
      19 (4.34 cM)5
    816011  NM_178637.21  NP_848752.11 
     56030175 
    chicken
    (Gallus gallus)
    Aves KAT56
    K(lysine) acetyltransferase 5
    97(a)
    1 ↔ 1
    AADN03015811.1(21-2708)
    lizard
    (Anolis carolinensis)
    Reptilia KAT56
    K(lysine) acetyltransferase 5
    94(a)
    1 ↔ 1
    GL344689.1(1719-10588)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142382 Xenopus laevis transcribed sequences 79.78(n)    BJ617444.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpla22 Transcribed sequence with strong similarity to protein more 77.71(n)    BI889237.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tip601 Tip60 60.73(n)
    62.75(a)
      31362  NM_001272305.1  NP_001259234.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mys-11 mys-1 53.79(n)
    55.5(a)
      179096  NM_072395.3  NP_504796.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESA1(YOR244W)4
    ESA11
    Catalytic subunit of the histone acetyltransferase more4
    ESA11
    50.41(n)1
    51.48(a)1
      15(792531-793868)4
    8544181, 4  NP_014887.31  NP_014887.14 


    ENSEMBL Gene Tree for KAT5 (if available)
    TreeFam Gene Tree for KAT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KAT5 gene
    KAT6B2  KAT72  KAT6A2  KAT82  
    7 SIMAP similar genes for KAT5 using alignment to 8 protein entries:     KAT5_HUMAN (see all proteins):
    KAT8    KAT7    KAT6A    MYST3    KAT6B    MYST4
    DKFZp313G1618

    Find genes that share paralogs with KAT5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for KAT5 (see all 318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811801871,2
    --65398215(+) CAAACC/TTGCTT 4 -- us2k10--------
    rs3753826351,2
    C--65398246(+) CAATTC/TTTTTT 4 -- us2k10--------
    rs112272701,2
    C,A--65398328(+) ACCTCC/TGCCTC 4 -- us2k11Minor allele frequency- T:0.50NA 2
    rs112272711,2
    C,A--65398399(+) CACCAC/TGCCTG 4 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1858343881,2
    C--65398462(+) GGTCTC/TGAACT 4 -- us2k10--------
    rs1903047151,2
    --65398474(+) CTGACA/CTCAGG 4 -- us2k10--------
    rs1821047641,2
    --65398496(+) CCTGGC/TCTCCC 4 -- us2k10--------
    rs1859942311,2
    --65398510(+) GTGCTA/GGACTC 4 -- us2k10--------
    rs340071461,2
    C,F--65398637(+) GGCAGG/AAAAAT 4 -- us2k17Minor allele frequency- A:0.22NA WA EA 366
    rs124185671,2
    C,F,H--65398646(+) ataggG/Atctgg 4 -- us2k18Minor allele frequency- A:0.25NA WA EA 368

    HapMap Linkage Disequilibrium report for KAT5 (65479467 - 65487077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KAT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897723CNV Loss21882294
    dgv1175n71CNV Loss21882294
    nsv897718CNV Loss21882294
    dgv1180n71CNV Loss21882294
    nsv897736CNV Loss21882294
    nsv897755CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KAT5
    DNA2.0 Custom Variant and Variant Library Synthesis for KAT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601409    OMIM disorders: --

    2 diseases for KAT5:    
    About MalaCards
    hiv-1    kaposi's sarcoma


    Find genes that share disorders with KAT5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KAT5 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 68.2 23 9220394 (1), 9430704 (1), 11282025 (1), 15719058 (1) (see all 22)
    leukemogenesis 37.8 2 18239623 (1)
    aids 22.2 2 19279332 (1), 1431144 (1)
    kaposi sarcoma 22.2 1 11461682 (1)
    prostate cancer 13.7 5 19938016 (1), 18397884 (1), 15947099 (1), 15663989 (1) (see all 5)
    leukemia 0 3 18239623 (1), 12737628 (1)
    herpes simplex 0 1 16508684 (1)
    necrosis 0 1 8419639 (1)
    metastasis 0 3 15829968 (2), 19846935 (1)
    hiv infections 0 1 14769003 (1)

    Human Genome Epidemiology (HuGE) Navigator: KAT5 (1 document)

    Export disorders for KAT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KAT5 gene, integrated from 10 sources (see all 310):
    (articles sorted by number of sources associating them with KAT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. (PubMed id 8607265)1, 2, 3, 9 Kamine J.... Chinnadurai G. (Virology 1996)
    2. PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. (PubMed id 11416127)1, 2, 9 Sheridan A.M.... Bonventre J.V. (Mol. Cell. Biol. 2001)
    3. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PubMed id 17704809)1, 2, 9 Cheng Z.... Yao X. (Oncogene 2008)
    4. Regulation of TIP60 by ATF2 modulates ATM activation. (PubMed id 18397884)1, 2, 9 Bhoumik A....Ronai Z.A. (J. Biol. Chem. 2008)
    5. Tip60 is a co-repressor for STAT3. (PubMed id 12551922)1, 2, 9 Xiao H.... Yang Y.-C. (J. Biol. Chem. 2003)
    6. Role of the histone acetyl transferase Tip60 in the p53 pathway. (PubMed id 15310756)1, 2, 9 Legube G.... Trouche D. (J. Biol. Chem. 2004)
    7. Tip60 acetylates six lysines of a specific class in core histones in vitro. (PubMed id 10096020)1, 2, 9 Kimura A. and Horikoshi M. (Genes Cells 1998)
    8. HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (PubMed id 16001085)1, 2, 9 Col E.... Khochbin S. (EMBO J. 2005)
    9. Identification of a larger form of the histone acetyl transferase Tip60. (PubMed id 12801643)1, 2, 9 Legube G. and Trouche D. (Gene 2003)
    10. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. (PubMed id 11927554)1, 2, 9 Legube G....Trouche D. (EMBO J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10524 HGNC: 5275 AceView: HTATIP Ensembl:ENSG00000172977 euGenes: HUgn10524
    ECgene: KAT5 Kegg: 10524 H-InvDB: KAT5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KAT5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KAT5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/htatip/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KAT5 gene:
    Search GeneIP for patents involving KAT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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