Aliases for KAT2B Gene
External Ids for KAT2B Gene
Previous HGNC Symbols for KAT2B Gene
Previous GeneCards Identifiers for KAT2B Gene
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for KAT2B Gene
KAT2B (Lysine Acetyltransferase 2B) is a Protein Coding gene. Diseases associated with KAT2B include Spinocerebellar Ataxia 7 and Holt-Oram Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include protein kinase binding and transcription coactivator activity. An important paralog of this gene is KAT2A.
UniProtKB/Swiss-Prot for KAT2B Gene
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.