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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KAT2B Gene

protein-coding   GIFtS: 68
GCID: GC03P020081

K(Lysine) Acetyltransferase 2B

(Previous name: p300/CBP-associated factor)
(Previous symbol: PCAF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
K(Lysine) Acetyltransferase 2B1 2     P/CAF2 3
P300/CBP-Associated Factor1 2 3     EC 2.3.1.483 8
PCAF1 2 3     CAF2 5
Histone Acetylase PCAF2 3     P2
Histone Acetyltransferase PCAF2 3     CREBBP-Associated Factor2
Lysine Acetyltransferase 2B2 3     Histone Acetyltransferase KAT2B2

External Ids:    HGNC: 86381   Entrez Gene: 88502   Ensembl: ENSG000001141667   OMIM: 6023035   UniProtKB: Q928313   

Export aliases for KAT2B gene to outside databases

Previous GC identifers: GC03P020057 GC03P020021


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KAT2B Gene:
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or
differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates
with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding
sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles,
indicating that this protein plays a direct role in transcriptional regulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for KAT2B Gene: 
KAT2B (K(lysine) acetyltransferase 2B) is a protein-coding gene. Diseases associated with KAT2B include holt-oram syndrome, and enamel erosion, and among its related super-pathways are Notch signaling pathway and Constitutive Signaling by NOTCH1 PEST Domain Mutants. GO annotations related to this gene include transcription coactivator activity and protein kinase binding. An important paralog of this gene is BAZ1A.

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831
Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant
histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles.
Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case
of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may
help inducing chromatin remodeling of proviral genes

Gene Wiki entry for KAT2B (PCAF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KAT2B gene promoter:
         c-Fos   AP-1   ATF-2   MyoD   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKAT2B promoter sequence
   Search SABiosciences Chromatin IP Primers for KAT2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24

KAT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P020081:  view genomic region     (about GC identifiers)

Start:
20,081,515 bp from pter      End:
20,195,896 bp from pter
Size:
114,382 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT2B  
Size: 832 amino acids; 93013 Da
Subunit: Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation
activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a
large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with
NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2.
Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not
acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with
MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional
activity
Subcellular location: Nucleus (By similarity)
6/9 PDB 3D structures from and Proteopedia for KAT2B (see all 9):
1CM0 (3D)        1JM4 (3D)        1N72 (3D)        1WUG (3D)        1WUM (3D)        1ZS5 (3D)    
Secondary accessions: Q6NSK1

Explore the universe of human proteins at neXtProt for KAT2B: NX_Q92831

Explore proteomics data for KAT2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92831

  • 2 DME Specific Peptides for KAT2B (Q92831)
     EQVKGYGT  YAIGYFKKQGF 

    KAT2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KAT2B Protein Expression
    REFSEQ proteins: NP_003875.3  
    ENSEMBL proteins: 
     ENSP00000263754  
    Reactome Protein details: Q92831
    Human Recombinant Protein Products for KAT2B: 
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    Cloud-Clone Corp. Proteins for KAT2B 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex ----
    GO:0000125PCAF complex NAS18669648
    GO:0000776kinetochore IEA--
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--

    KAT2B for ontologies           About GeneDecksing



    KAT2B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    5/6 InterPro protein domains (see all 6):
     IPR009464 PCAF_N
     IPR000182 GNAT_dom
     IPR018359 Bromodomain_CS
     IPR016376 Hist_acetylase_PCAF
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92831

    ProtoNet protein and cluster: Q92831

    3 Blocks protein domains:
    IPB000182 GCN5-related N-acetyltransferase
    IPB001487 Bromodomain signature
    IPB009464 PCAF


    UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831
    Domain: The bromodomain mediates binding to HIV-1 Tat
    Similarity: Belongs to the GCN5 family
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 N-acetyltransferase domain


    KAT2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT2B_HUMAN, Q92831
    Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant
    histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles.
    Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case
    of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may
    help inducing chromatin remodeling of proviral genes
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity IPI8684459
    GO:0003713transcription coactivator activity IDA12435739
    GO:0004402histone acetyltransferase activity IEA--
    GO:0004468lysine N-acetyltransferase activity ISS--
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity ISS--
         
    KAT2B for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kat2b):
     embryogenesis  growth/size  mortality/aging  normal 

    KAT2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KAT2B: Kat2btm1Nkt Kat2btm1Roth

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KAT2B 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KAT2B
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT2B (see all 61):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-25 hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidKAT2B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KAT2B About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    3RNA Polymerase I Chain Elongation
    RNA Polymerase I Promoter Clearance0.92
    RNA Polymerase I Transcription Initiation0.90
    RNA Polymerase I Transcription0.92
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    5Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for KAT2B (see all 8)
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Notch Signaling Pathway
    Immune response Function of MEF2 in T lymphocytes
    Transcription Sin3 and NuRD in transcription regulation


    1 Cell Signaling Technology (CST) Pathway for KAT2B
        Chromatin Regulation / Acetylation

    5/8 GeneGo (Thomson Reuters) Pathways for KAT2B (see all 8)
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation

    5/12 BioSystems Pathways for KAT2B (see all 12)
        Notch Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Androgen receptor signaling pathway
    Delta-Notch Signaling Pathway
    Signaling events mediated by HDAC Class I

    5/23        Reactome Pathways for KAT2B (see all 23)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Notch-HLH transcription pathway
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    3         Kegg Pathways  (Kegg details for KAT2B):
        Notch signaling pathway
    HTLV-I infection
    Viral carcinogenesis


    KAT2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KAT2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/296 Interacting proteins for KAT2B (Q928311, 2, 3 ENSP000002637544) via UniProtKB, MINT, STRING, and/or I2D (see all 296)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=3 STRING: ENSP00000352980
    HIST4H4P628053, ENSP000003507674I2D: score=3 STRING: ENSP00000350767
    BUB1BO605662, 3, ENSP000002875984MINT-7299990 MINT-7300008 MINT-7299777 MINT-7299740 MINT-7299797 MINT-7300223 MINT-7300201 MINT-7300263 MINT-7300283 MINT-7300181 MINT-7299749 MINT-7300243 MINT-7299763 I2D: score=2 STRING: ENSP00000287598
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling NAS10365964
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    KAT2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KAT2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KAT2B

    2 HMDB Compounds for KAT2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    3 DrugBank Compounds for KAT2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE-- --target--10592235
    N-(3-AMINOPROPYL)-2-NITROBENZENAMINE-- --target--10592235
    Coenzyme A-- 85-61-0target----

    10/12 Novoseek inferred chemical compound relationships for KAT2B gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 68 21 11931765 (4), 19351588 (2), 12486002 (2), 9891054 (2) (see all 14)
    polypropylene glycol 42 1 16862175 (1)
    acetyl-coa 35.3 11 9341171 (2), 15289617 (1), 10777508 (1)
    steroid 26.1 7 12790809 (1), 10453284 (1), 9296499 (1), 10845098 (1) (see all 6)
    retinoic acid 25.3 8 15489004 (4), 18443043 (1), 17389641 (1), 14980312 (1)
    curcumin 10.9 1 16787365 (1)
    estrogen 10.7 2 16309230 (1), 16152593 (1)
    lead 0 1 17444627 (1)
    progesterone 0 2 12790809 (1), 19609353 (1)
    zinc 0 6 18663001 (2), 12758070 (1), 12813456 (1), 11486036 (1)

    Search CenterWatch for drugs/clinical trials and news about KAT2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for KAT2B gene: 
    NM_003884.4  

    Unigene Cluster for KAT2B:

    K(lysine) acetyltransferase 2B
    Hs.533055  [show with all ESTs]
    Unigene Representative Sequence: NM_003884
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263754(uc003cbq.3) ENST00000426228 ENST00000469085 ENST00000468111
    ENST00000468400
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AL832173.1 BC060823.1 BC070075.1 U57317.2 

    6 DOTS entries:

    DT.413547  DT.455550  DT.100817054  DT.120923372  DT.92441615  DT.95167340 

    24/147 AceView cDNA sequences (see all 147):

    BC070075 AA932428 BU154737 BU678653 AI472591 T07150 BC060823 T91333 
    AA766914 AI749010 AW026794 AI359344 AA643963 AI470982 BU171918 CR592587 
    AW192906 BQ003704 AI473523 AW051871 CA395463 BF196582 CD723514 NM_003884 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                                                  -           -                             -                             -                       -         
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for KAT2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KAT2B expression in normal human tissues (normalized intensities)      KAT2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAGTTTG
    KAT2B Expression
    About this image


    KAT2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd3+ t cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See KAT2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KAT2B

    SOURCE GeneReport for Unigene cluster: Hs.533055

    UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831
    Tissue specificity: Ubiquitously expressed but most abundant in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including KAT2B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KAT2B gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat2b1 , 5 K(lysine) acetyltransferase 2B1, 5 88.12(n)1
    93.71(a)1
      17 (27.86 cM)5
    185191  NM_020005.41  NP_064389.21 
     535668615 
    chicken
    (Gallus gallus)
    Aves KAT2B1 K(lysine) acetyltransferase 2B 82.74(n)
    91.55(a)
      428441  XM_426001.3  XP_426001.3 
    lizard
    (Anolis carolinensis)
    Reptilia KAT2B6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    6(32865073-32894860)
    zebrafish
    (Danio rerio)
    Actinopterygii kat2b1 K(lysine) acetyltransferase 2B 72.16(n)
    81.86(a)
      563942  NM_001045034.1  NP_001038499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pcaf6
    Pcaf
    45(a)
    1 → many
    3L(12514229-12517114)
    worm
    (Caenorhabditis elegans)
    Secernentea pcaf-16
    Protein PCAF-1
    31(a)
    1 → many
    I(3516478-3523387)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCN5(YGR252W)4
    GCN51
    Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay less4
    Gcn5p1
    54.09(n)1
    48.54(a)1
      7(996869-998188)4
    8531671, 4  NP_011768.11, 4 


    ENSEMBL Gene Tree for KAT2B (if available)
    TreeFam Gene Tree for KAT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KAT2B gene
    BAZ1A2  BPTF2  BAZ2B2  CECR22  BAZ2A2  BAZ1B2  KAT2A2  
    1 SIMAP similar gene for KAT2B using alignment to 1 protein entry:     KAT2B_HUMAN:
    KAT2A

    KAT2B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KAT2B
    PGOHUM00000249303


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2572 SNPs in KAT2B are shown (see all 2572)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922914671,2
    --20079626(+) GTTCAC/GTTAAT 1 -- us2k10--------
    rs1384110871,2
    --20079741(+) ATTCTA/GAGGGA 1 -- us2k10--------
    rs1165465651,2
    C,F--20079800(+) CCTCCC/ACCAAT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1137836681,2
    C--20079805(+) CCAAT-/ATGTCA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1492470891,2
    --20079853(+) ATTGCA/GCACTG 1 -- us2k10--------
    rs750750071,2
    C,F--20079867(+) CCATTA/CCCTAG 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs126390781,2
    C,F,A,H--20079878(+) ACTCTA/GTTATA 1 -- us2k114Minor allele frequency- G:0.27NS EA EU NA WA 1108
    rs1393694171,2
    --20079984(+) CAAAGA/CGCACC 1 -- us2k10--------
    rs1432779311,2
    --20079994(+) CATTAC/GAGTTC 1 -- us2k10--------
    rs176269381,2
    C,F,H--20080132(+) TTAGTA/GTCTGT 1 -- us2k1 tfbs319Minor allele frequency- G:0.09NA NS EA WA 2546

    HapMap Linkage Disequilibrium report for KAT2B (20081515 - 20195896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KAT2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422249CNV Deletion17116639
    esv267763CNV Insertion20981092
    nsv470450CNV Loss18288195
    nsv834627CNV Loss17160897
    nsv3719CNV Loss18451855
    nsv237514CNV Loss16902084
    esv35078CNV Gain17911159
    nsv433359CNV Gain18776910
    esv23068CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602303    OMIM disorders: --

    20/27 diseases for KAT2B (see all 27):    About MalaCards
    holt-oram syndrome    enamel erosion    werner syndrome    endocarditis
    sporadic breast cancer    human t-cell leukemia virus type 1    prostate cancer, progression of    gout
    rhabdomyosarcoma    prostate cancer    t-cell leukemia    cytochrome p450
    esophageal squamous cell carcinoma    retinoblastoma    breast cancer    inflammatory bowel disease
    prostatitis    ovarian cancer    esophagitis    hypoxia

    2 diseases from the University of Copenhagen DISEASES database for KAT2B:
    Enamel erosion     Plague

    KAT2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for KAT2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 3.38 2 17496784 (2)
    cancer 0.719 4 12402157 (2), 16638127 (1), 17725108 (1)
    leukemia 0 1 12878208 (1)
    virus infection 0 1 12743606 (1)
    glioma 0 1 10896202 (1)
    breast cancer 0 3 15009097 (1), 18089809 (1)
    tumors 0 21 10896202 (5), 17725108 (4), 15153330 (3), 17496784 (2) (see all 7)
    prostate cancer 0 1 17627840 (1)
    immunodeficiency 0 1 17444627 (1)

    Genetic Association Database (GAD): KAT2B
    Human Genome Epidemiology (HuGE) Navigator: KAT2B (7 documents)

    Export disorders for KAT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KAT2B gene, integrated from 9 sources (see all 401):
    (articles sorted by number of sources associating them with KAT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. (PubMed id 8684459)1, 2, 3 Yang X.-J.... Nakatani Y. (1996)
    2. Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. (PubMed id 12486002)1, 2, 9 Bres V.... Kiernan R.E. (2002)
    3. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. (PubMed id 11931765)1, 2, 9 Mujtaba S.... Zhou M.-M. (2002)
    4. The transcriptional coactivators p300 and CBP are histone acetyltransferases. (PubMed id 8945521)1, 2, 9 Ogryzko V.V.... Nakatani Y. (1996)
    5. Steroid receptor coactivator-1 is a histone acetyltransferase. (PubMed id 9296499)1, 2, 9 Spencer T.E....O'Malley B.W. (1997)
    6. Single nucleotide polymorphisms in miRNA binding site s and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk w omen. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (2009)
    7. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PubMed id 17226766)1, 2 Shin S. and Janknecht R. (2007)
    8. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. (PubMed id 17707232)1, 2 Zhu P....Rosenfeld M.G. (2007)
    9. Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. (PubMed id 15273251)1, 2 Zhao Q.... Jane S.M. (2004)
    10. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2 Gangisetty O.... Still I.H. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8850 HGNC: 8638 AceView: PCAF Ensembl:ENSG00000114166 euGenes: HUgn8850
    ECgene: KAT2B Kegg: 8850 H-InvDB: KAT2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KAT2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KAT2B gene:
    Search GeneIP for patents involving KAT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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