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Aliases for KAT2B Gene

Aliases for KAT2B Gene

  • Lysine Acetyltransferase 2B 2 3 4 5
  • P300/CBP-Associated Factor 2 3 4
  • K(Lysine) Acetyltransferase 2B 2 3
  • Histone Acetyltransferase PCAF 3 4
  • Histone Acetylase PCAF 3 4
  • EC 2.3.1.48 4 61
  • P/CAF 3 4
  • PCAF 3 4
  • Histone Acetyltransferase KAT2B 3
  • CREBBP-Associated Factor 3
  • CAF 3

External Ids for KAT2B Gene

Previous HGNC Symbols for KAT2B Gene

  • PCAF

Previous GeneCards Identifiers for KAT2B Gene

  • GC03P020057
  • GC03P020021

Summaries for KAT2B Gene

Entrez Gene Summary for KAT2B Gene

  • CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT2B Gene

KAT2B (Lysine Acetyltransferase 2B) is a Protein Coding gene. Diseases associated with KAT2B include Hiv-1. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and HTLV-I infection. GO annotations related to this gene include protein kinase binding and transcription coactivator activity. An important paralog of this gene is KAT2A.

UniProtKB/Swiss-Prot for KAT2B Gene

  • Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

Gene Wiki entry for KAT2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2B Gene

Genomics for KAT2B Gene

Regulatory Elements for KAT2B Gene

Enhancers for KAT2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F020184 1.1 ENCODE 22.9 +146.8 146761 4.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 KAT2B SGO1 SGO1-AS1
GH03F020080 1.4 FANTOM5 Ensembl ENCODE 17.2 +41.3 41254 0.9 HDGF ELF3 PKNOX1 MLX ARID4B THRB ZBTB40 RAD21 YY1 RARA KAT2B GC03M020070 GC03M020054
GH03F020103 1.3 FANTOM5 Ensembl ENCODE 18.1 +64.5 64486 2.1 HDAC1 ESRRA ATF1 GATA3 GATA2 EED CREM HES1 ZNF362 MTA2 KAT2B GC03M020070 GC03P020132
GH03F020052 1.7 FANTOM5 Ensembl ENCODE 11.3 +15.7 15678 5.8 HDGF PKNOX1 SIN3A FEZF1 YY1 FOS DEK ZNF263 JUNB TSHZ1 KAT2B RAB5A EFHB GC03M020054
GH03F020060 1.3 FANTOM5 Ensembl ENCODE 13.6 +21.1 21079 1.4 RFX1 HLF CEBPB CEBPG EP300 RAD21 YY1 IRF9 ZNF121 RAD51 KAT2B RAB5A GC03M020054 GC03M020070
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KAT2B on UCSC Golden Path with GeneCards custom track

Promoters for KAT2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001359037 277 3401 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 KLF13

Genomic Location for KAT2B Gene

Chromosome:
3
Start:
20,040,023 bp from pter
End:
20,154,404 bp from pter
Size:
114,382 bases
Orientation:
Plus strand

Genomic View for KAT2B Gene

Genes around KAT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT2B Gene

Proteins for KAT2B Gene

  • Protein details for KAT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92831-KAT2B_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2B
    Protein Accession:
    Q92831
    Secondary Accessions:
    • Q6NSK1

    Protein attributes for KAT2B Gene

    Size:
    832 amino acids
    Molecular mass:
    93013 Da
    Quaternary structure:
    • Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK. Interacts with BCAS3. Interacts with CEBPB (PubMed:17301242). Interacts with NR4A3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for KAT2B Gene

neXtProt entry for KAT2B Gene

Selected DME Specific Peptides for KAT2B Gene

Q92831:
  • YAIGYFKKQGF
  • EQVKGYGT

Post-translational modifications for KAT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KAT2B Gene

Domains & Families for KAT2B Gene

Suggested Antigen Peptide Sequences for KAT2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92831

UniProtKB/Swiss-Prot:

KAT2B_HUMAN :
  • The bromodomain mediates binding to HIV-1 Tat.
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Domain:
  • The bromodomain mediates binding to HIV-1 Tat.
  • Contains 1 bromo domain.
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2B: view

Function for KAT2B Gene

Molecular function for KAT2B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

Enzyme Numbers (IUBMB) for KAT2B Gene

Gene Ontology (GO) - Molecular Function for KAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003682 chromatin binding IEA,ISS --
GO:0003712 transcription cofactor activity IPI 8684459
GO:0003713 transcription coactivator activity IDA 12435739
GO:0004402 histone acetyltransferase activity EXP,IMP 16829519
genes like me logo Genes that share ontologies with KAT2B: view
genes like me logo Genes that share phenotypes with KAT2B: view

Animal Models for KAT2B Gene

MGI Knock Outs for KAT2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for KAT2B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2B

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2B Gene

Localization for KAT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT2B gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex NAS 17707232
GO:0000776 kinetochore IEA --
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with KAT2B: view

Pathways & Interactions for KAT2B Gene

genes like me logo Genes that share pathways with KAT2B: view

SIGNOR curated interactions for KAT2B Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS,TAS 10365964
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006473 protein acetylation TAS 8684459
genes like me logo Genes that share ontologies with KAT2B: view

Drugs & Compounds for KAT2B Gene

(19) Drugs for KAT2B Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE Experimental Pharma Target 0
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE Experimental Pharma Target 0
Coenzyme A Nutra Target 0
Anacardic acid Pharma HAT inhibitor, Noncompetitive PCAF/p300 inhibitor 0
Garcinol Pharma PCAF/p300 inhibitor; anticancer 0

(6) Additional Compounds for KAT2B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(5) ApexBio Compounds for KAT2B Gene

Compound Action Cas Number
Anacardic acid HAT inhibitor 16611-84-0
Donepezil HCl AChE inhibitor 120011-70-3
Garcinol 78824-30-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT2B: view

Drug Products

Transcripts for KAT2B Gene

Unigene Clusters for KAT2B Gene

K(lysine) acetyltransferase 2B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for KAT2B Gene

GeneLoc Exon Structure for
KAT2B
ECgene alternative splicing isoforms for
KAT2B

Expression for KAT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KAT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2B Gene

This gene is overexpressed in Nasal epithelium (52.7) and Cervix (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT2B Gene



NURSA nuclear receptor signaling pathways regulating expression of KAT2B Gene:

KAT2B

SOURCE GeneReport for Unigene cluster for KAT2B Gene:

Hs.533055

mRNA Expression by UniProt/SwissProt for KAT2B Gene:

Q92831-KAT2B_HUMAN
Tissue specificity: Ubiquitously expressed but most abundant in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with KAT2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for KAT2B Gene

Orthologs for KAT2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT2B 34 35
  • 99.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KAT2B 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT2B 34 35
  • 90.06 (n)
cow
(Bos Taurus)
Mammalia KAT2B 34
  • 88.69 (n)
PCAF 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat2b 34 16 35
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Pcaf 34
  • 88.28 (n)
oppossum
(Monodelphis domestica)
Mammalia KAT2B 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KAT2B 34 35
  • 83.08 (n)
lizard
(Anolis carolinensis)
Reptilia KAT2B 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat2b 34
  • 76.82 (n)
zebrafish
(Danio rerio)
Actinopterygii kat2b 34 35
  • 73.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pcaf 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pcaf-1 34 35
  • 47.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER297C 34
  • 55.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN5 34 35 37
  • 54.28 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05115g 34
  • 52.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5837 35
  • 55 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gcn5 34
  • 53.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10847 34
  • 51.82 (n)
Species where no ortholog for KAT2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2B Gene

ENSEMBL:
Gene Tree for KAT2B (if available)
TreeFam:
Gene Tree for KAT2B (if available)

Paralogs for KAT2B Gene

Paralogs for KAT2B Gene

(1) SIMAP similar genes for KAT2B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KAT2B Gene

genes like me logo Genes that share paralogs with KAT2B: view

Variants for KAT2B Gene

Sequence variations from dbSNP and Humsavar for KAT2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10084714 -- 20,141,840(+) AAAGA(C/T)GTCAG intron-variant
rs10428107 -- 20,131,118(+) tctgg(A/T)gattc intron-variant
rs10428249 -- 20,131,179(+) cccgg(C/G)taatt intron-variant
rs1046039 -- 20,154,259(+) atatt(A/T)tCTTA nc-transcript-variant, utr-variant-3-prime
rs10510498 -- 20,146,809(+) AGTAA(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT2B Gene

Variant ID Type Subtype PubMed ID
nsv997486 CNV gain 25217958
nsv834627 CNV loss 17160897
nsv470450 CNV loss 18288195
nsv433359 CNV gain 18776910
nsv3719 CNV deletion 18451855
nsv237514 CNV deletion 16902084
nsv1143045 CNV tandem duplication 24896259
nsv1142354 CNV tandem duplication 24896259
nsv1140170 CNV insertion 24896259
esv3893669 CNV loss 25118596
esv3893667 CNV gain 25118596
esv3595471 CNV loss 21293372
esv3568636 CNV loss 25503493
esv35078 CNV gain 17911159
esv3434589 CNV insertion 20981092
esv2422249 CNV deletion 17116639
esv23068 CNV gain+loss 19812545

Variation tolerance for KAT2B Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2B Gene

Disorders for KAT2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KAT2B Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KAT2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for KAT2B

Genetic Association Database (GAD)
KAT2B
Human Genome Epidemiology (HuGE) Navigator
KAT2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT2B
genes like me logo Genes that share disorders with KAT2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT2B Gene

Publications for KAT2B Gene

  1. Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. (PMID: 17301242) Wiper-Bergeron N. … HachAc R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 22 64
  2. Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. (PMID: 12486002) Bres V. … Kiernan R.E. (EMBO J. 2002) 3 4 22 64
  3. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. (PMID: 11931765) Mujtaba S. … Zhou M.-M. (Mol. Cell 2002) 3 4 22 64
  4. Steroid receptor coactivator-1 is a histone acetyltransferase. (PMID: 9296499) Spencer T.E. … O'Malley B.W. (Nature 1997) 3 4 22 64
  5. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. (PMID: 8684459) Yang X.-J. … Nakatani Y. (Nature 1996) 2 3 4 64

Products for KAT2B Gene

Sources for KAT2B Gene

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