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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KAT2B Gene

protein-coding GIFtS: 67
GCID: GC03P020081

K(lysine) acetyltransferase 2B

(Previous name: p300/CBP-associated factor )
(Previous symbol: PCAF)

Explore 33 diseases affiliated with
KAT2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
K(Lysine) Acetyltransferase 2B¹ ²		EC 2.3.1.48³ ⁸
P300/CBP-Associated Factor¹ ² ³		CAF² ⁵
P/CAF¹ ² ³		GCN5¹
PCAF¹ ² ³		GCN5L¹
Histone Acetylase PCAF² ³		P²
Histone Acetyltransferase PCAF² ³		CREBBP-Associated Factor²
Lysine Acetyltransferase 2B² ³		Histone Acetyltransferase KAT2B²

External Ids:	HGNC: 8638¹	Entrez Gene: 8850²	Ensembl: ENSG00000114166⁷	OMIM: 602303⁵	UniProtKB: Q92831³

Export aliases for KAT2B gene to outside databases

Previous GC identifers: GC03P020057 GC03P020021

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KAT2B:

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or

differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with

p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in

p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that

this protein plays a direct role in transcriptional regulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831

Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone

acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits

cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1

infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing

chromatin remodeling of proviral genes

Gene Wiki entry for KAT2B (PCAF)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KAT2B gene promoter:
c-Fos AP-1 ATF-2 MyoD STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KAT2B promoter sequence

Search SABiosciences Chromatin IP Primers for KAT2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24

KAT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT2B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P020081: view genomic region (about GC identifiers)

Start:	20,081,515 bp from pter	End:	20,195,896 bp from pter
Size:	114,382 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831 (See protein sequence)

Recommended Name: Histone acetyltransferase KAT2B

Size: 832 amino acids; 93013 Da

Subunit: Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation

activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large

chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2

(hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to

HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and

there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with

E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity

Subcellular location: Nucleus (By similarity)

6/9 PDB 3D structures from and Proteopedia for KAT2B (see all 9):

1CM0 (3D)

1JM4 (3D)

1N72 (3D)

1WUG (3D)

1WUM (3D)

1ZS5 (3D)

Secondary accessions: Q6NSK1

Explore the universe of human proteins at neXtProt for KAT2B: NX_Q92831

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92831

2 DME Specific Peptides for KAT2B (Q92831)

EQVKGYGT

YAIGYFKKQGF

KAT2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003875.3

ENSEMBL proteins:

ENSP00000263754

Reactome Protein details: Q92831
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant KAT2B Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for KAT2B
	OriGene Purified Proteins (see all 2): KAT2B OriGene Protein Over-expression Lysate: KAT2B OriGene Custom Protein Services for KAT2B
	GenScript Custom Purified and Recombinant Proteins Services for KAT2B
	Novus Biologicals KAT2B Proteins Novus Biologicals KAT2B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KAT2B

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000123	histone acetyltransferase complex	--	--
GO:0000125	PCAF complex	NAS	18669648
GO:0000776	kinetochore	IEA	--
GO:0005634	nucleus	ISS	--
GO:0005654	nucleoplasm	TAS	--

KAT2B for ontologies About GeneDecksing

KAT2B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KAT2B
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KAT2B (PCAF)
	OriGene Antibodies: KAT2B OriGene Custom Antibody Services for KAT2B
	GenScript Custom Superior Antibodies Services for KAT2B
	Novus Biologicals KAT2B Antibodies
	Abcam antibodies for KAT2B
	Uscn Antibodies for KAT2B
	ThermoFisher Antibody for KAT2B

Assay Products for KAT2B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KAT2B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KAT2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KAT2B for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR009464 PCAF_N

IPR000182 GNAT_dom

IPR018359 Bromodomain_CS

IPR016376 Hist_acetylase_PCAF

IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry Q92831

ProtoNet protein and cluster: Q92831

3 Blocks protein families:

IPB000182 GCN5-related N-acetyltransferase

IPB001487 Bromodomain signature

IPB009464 PCAF

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831

Domain: The bromodomain mediates binding to HIV-1 Tat

Similarity: Belongs to the GCN5 family

Similarity: Contains 1 bromo domain

Similarity: Contains 1 N-acetyltransferase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831

Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone

acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits

cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1

infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing

chromatin remodeling of proviral genes

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Enzyme Number (IUBMB): EC 2.3.1.48¹ ²

miRNA Products:		miRTarBase miRNAs that target KAT2B: hsa-mir-181a (MIRT004327), hsa-mir-19a (MIRT004334), hsa-mir-93 (MIRT004332), hsa-mir-92a (MIRT004331), hsa-mir-19b (MIRT004335), hsa-mir-32 (MIRT004330), hsa-mir-25 (MIRT004329), hsa-mir-106b (MIRT004333), hsa-mir-181b (MIRT004328)

		OriGene 3'-UTR Clone: KAT2B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KAT2B
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT2B (see all 61):
		hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-25 hsa-miR-570 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: KAT2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KAT2B OriGene shRNA RFP: KAT2B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT2B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KAT2B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KAT2B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KAT2B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KAT2B (NM_003884)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT2B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT2B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KAT2B
		Search LifeMap BioReagents cell lines for KAT2B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2B

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003712	transcription cofactor activity	IPI	8684459
GO:0003713	transcription coactivator activity	IDA	12435739
GO:0004402	histone acetyltransferase activity	IEA	--
GO:0004468	lysine N-acetyltransferase activity	ISS	--
GO:0004861	cyclin-dependent protein kinase inhibitor activity	ISS	--

KAT2B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for KAT2B: Kat2b^tm1Nkt Kat2b^tm1Roth
     4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kat2b):

embryogenesis

growth/size

mortality/aging

normal

KAT2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/11 pathways (see all 11)
Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH	0.77
Signaling by NOTCH1 in Cancer	1.00	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.71

Notch Signaling Pathway

	Notch Signaling Pathway	1.00			Delta-Notch Signaling Pathway	0.27
	Notch signaling pathway	0.82

RNA Polymerase I Chain Elongation

	RNA Polymerase I Transcription Initiation	0.90			RNA Polymerase I Transcription	0.79
	RNA Polymerase I Promoter Clearance	0.86

Transcription_Sin3 and NuRD in transcription regulation

Transcription_Sin3 and NuRD in transcription regulation

1.00

Transcription Sin3 and NuRD in transcription regulation

0.96

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for KAT2B (see all 8)

	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Development Notch Signaling Pathway
	Immune response Function of MEF2 in T lymphocytes
	Transcription Sin3 and NuRD in transcription regulation

1 Cell Signaling Technology (CST) Pathway for KAT2B

Chromatin Regulation / Acetylation

5/8 GeneGo (Thomson Reuters) Pathways for KAT2B (see all 8)

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Transcription P53 signaling pathway
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Sin3 and NuRD in transcription regulation

5/12 BioSystems Pathways for KAT2B (see all 12)

	Notch Signaling Pathway
	Delta-Notch Signaling Pathway
	Androgen receptor signaling pathway
	TGF-beta Receptor Signaling Pathway
	Signaling events mediated by HDAC Class I

5/23 Reactome Pathways for KAT2B (see all 23)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH1 Intracellular Domain Regulates Transcription
	FBXW7 Mutants and NOTCH1 in Cancer
	Notch-HLH transcription pathway
	Signaling by NOTCH1 HD Domain Mutants in Cancer

1 Kegg Pathway (Kegg details for KAT2B):

Notch signaling pathway

KAT2B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KAT2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/295 Interacting proteins for KAT2B (Q92831^{1, 2, 3} ENSP00000263754⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 295)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST4H4	P62805³, ENSP00000350767⁴	I2D: score=3 STRING: ENSP00000350767
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=3 STRING: ENSP00000352980
BUB1B	O60566²^,³, ENSP00000287598⁴	MINT-7299990 MINT-7300008 MINT-7299777 MINT-7299740 MINT-7299797 MINT-7300223 MINT-7300201 MINT-7300263 MINT-7300283 MINT-7300181 MINT-7299749 MINT-7300243 MINT-7299763 I2D: score=2 STRING: ENSP00000287598
HIST1H4B	P62805³	I2D: score=3
HIST1H4C	P62805³	I2D: score=3

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006338	chromatin remodeling	NAS	10365964
GO:0006360	transcription from RNA polymerase I promoter	TAS	--
GO:0006361	transcription initiation from RNA polymerase I promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006473	protein acetylation	TAS	8684459

KAT2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KAT2B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KAT2B

2 HMDB Compounds for KAT2B About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--

3 DrugBank Compounds for KAT2B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE	--	--	target	--	10592235
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE	--	--	target	--	10592235
Coenzyme A	--	85-61-0	target	--	--

10/12 Novoseek chemical compound relationships for KAT2B gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	68	21	11931765 (4), 19351588 (2), 12486002 (2), 9891054 (2) (see all 14)
polypropylene glycol	42	1	16862175 (1)
acetyl-coa	35.3	11	9341171 (2), 15289617 (1), 10777508 (1)
steroid	26.1	7	12790809 (1), 10453284 (1), 9296499 (1), 10845098 (1) (see all 6)
retinoic acid	25.3	8	15489004 (4), 18443043 (1), 17389641 (1), 14980312 (1)
curcumin	10.9	1	16787365 (1)
estrogen	10.7	2	16309230 (1), 16152593 (1)
lead	0	1	17444627 (1)
progesterone	0	2	12790809 (1), 19609353 (1)
zinc	0	6	18663001 (2), 12758070 (1), 12813456 (1), 11486036 (1)

Search CenterWatch for drugs/clinical trials and news about KAT2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KAT2B gene:

NM_003884.4

Unigene Cluster for KAT2B:

K(lysine) acetyltransferase 2B

Hs.533055 [show with all ESTs]

Unigene Representative Sequence: NM_003884

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263754(uc003cbq.3) ENST00000426228 ENST00000469085 ENST00000468111

ENST00000468400

miRNA Products:		OriGene 3'-UTR Clone: KAT2B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KAT2B
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT2B (see all 61):
		hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-25 hsa-miR-570 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: KAT2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KAT2B OriGene shRNA RFP: KAT2B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KAT2B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KAT2B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KAT2B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KAT2B (NM_003884)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT2B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT2B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KAT2B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KAT2B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KAT2B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KAT2B

Additional cDNA sequence:

AL832173.1 BC060823.1 BC070075.1 U57317.2

6 DOTS entries:

DT.413547 DT.455550 DT.100817054 DT.120923372 DT.92441615 DT.95167340

24/147 AceView cDNA sequences (see all 147):

AW192906 AL832173 AI749010 BF196582 NM_003884 AI473523 AW026794 CD723514

BQ003704 T07150 T91333 AA766914 BU171918 CA395463 BC060823 CA448582

BC070075 BU678653 AI470982 BM721529 CR592587 AW298563 AA643963 AI472591

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2B About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17a	·	17b	^	18
SP1:																	-				-										-										-								-
SP2:																															-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KAT2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KAT2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACAGTTTG

About this image

KAT2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KAT2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KAT2B

SOURCE GeneReport for Unigene cluster: Hs.533055

UniProtKB/Swiss-Prot: KAT2B_HUMAN, Q92831

Tissue specificity: Ubiquitously expressed but most abundant in heart and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including KAT2B:

Epigenetic Chromatin Modification Enzymes in human mouse rat

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Nuclear Receptors & Coregulators in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KAT2B gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kat2b^{1 , 5}	K(lysine) acetyltransferase 2B^{1, 5}	88.12(n)¹ 93.71(a)¹		17 (27.86 cM)⁵ 18519¹ NM_020005.4¹ NP_064389.2¹ 53566861⁵
chicken (Gallus gallus)	Aves	KAT2B¹	K(lysine) acetyltransferase 2B	82.74(n) 91.55(a)		428441 XM_426001.3 XP_426001.3
lizard (Anolis carolinensis)	Reptilia	KAT2B⁶	--	89(a)	1 ↔ 1	6(32869898-32894860)
zebrafish (Danio rerio)	Actinopterygii	kat2b¹	K(lysine) acetyltransferase 2B	72.16(n) 81.86(a)		563942 NM_001045034.1 NP_001038499.1
fruit fly (Drosophila melanogaster)	Insecta	Pcaf⁶	Pcaf	45(a)	1 → many	3L(12514229-12517114)
worm (Caenorhabditis elegans)	Secernentea	pcaf-1⁶	P300/CBP Associated Factor homolog family member (...	29(a)	1 → many	I(3516481-3523390)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCN5(YGR252W)⁴ GCN5¹	Acetyltransferase, modifies N-terminal lysines on histones more⁴ Gcn5p¹	54.09(n)¹ 48.54(a)¹		7(996869-998188)⁴ 853167^{1, 4} NP_011768.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	HAT1⁶	histone acetyltransferase GCN5	29(a)	1 → many	3(20213560-20217653)
rice (Oryza sativa)	Liliopsida	--	histone acetyltransferase GCN5, putative, expresse...	32(a)	1 → many	10(14477875-14484313)

ENSEMBL Gene Tree for KAT2B (if available)
TreeFam Gene Tree for KAT2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KAT2B gene

BAZ1A² BPTF² BAZ2A² BAZ2B² CECR2² BAZ1B² KAT2A²

1 SIMAP similar gene for KAT2B using alignment to 1 protein entry: KAT2B_HUMAN:

KAT2A

KAT2B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KAT2B
PGOHUM00000249303

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192291467^1,2		--	20079626(+)	`GTTCAC/GTTAAT`	1	--	us2k¹		0	--	--	--	--
rs138411087^1,2		--	20079741(+)	`ATTCTA/GAGGGA`	1	--	us2k¹		0	--	--	--	--
rs116546565^1,2	F,	--	20079800(+)	`CCTCCC/ACCAAT`	1	--	us2k¹		1		WA	118
rs113783668^1,2	C,	--	20079803(+)	`CCAAT-/ATGTCA`	1	--	us2k¹		1		CSA	2
rs149247089^1,2		--	20079853(+)	`ATTGCA/GCACTG`	1	--	us2k¹		0	--	--	--	--
rs75075007^1,2	F,	--	20079867(+)	`CCATTA/CCCTAG`	1	--	us2k¹		1		WA	118
rs12639078^1,2	C,F,A,H,	--	20079878(+)	`ACTCTA/GTTATA`	1	--	us2k¹		14		NS EA EU NA WA	1108
rs139369417^1,2		--	20079984(+)	`CAAAGA/CGCACC`	1	--	us2k¹		0	--	--	--	--
rs143277931^1,2		--	20079994(+)	`CATTAC/GAGTTC`	1	--	us2k¹		0	--	--	--	--
rs17626938^1,2	C,F,H,	--	20080132(+)	`TTAGTA/GTCTGT`	1	--	us2k¹ tfbs³		19		NA NS EA WA	2546

HapMap Linkage Disequilibrium report for KAT2B (20081515 - 20195896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for KAT2B
5 CNVs: 63413 37531 6164 5371 8415

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KAT2B for disorders           About GeneDecksing

OMIM gene information: 602303    OMIM disorders: --

20/33 diseases for KAT2B (see all 33):    About MalaCards

holt-oram syndrome human t-cell leukemia virus type 1 enamel erosion esophageal squamous cell carcinoma

squamous cell carcinoma inflammatory bowel disease sporadic breast cancer breast-ovarian cancer

plague werner syndrome t-cell leukemia prostate cancer

breast cancer prostate cancer, progression of ovarian cancer endocarditis

gout rhabdomyosarcoma hematopoiesis leukemia

2 diseases from the University of Copenhagen DISEASES database for KAT2B:

Enamel erosion Plague

9 Novoseek disease relationships for KAT2B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	3.38	2	17496784 (2)
cancer	0.719	4	12402157 (2), 16638127 (1), 17725108 (1)
leukemia	0	1	12878208 (1)
virus infection	0	1	12743606 (1)
glioma	0	1	10896202 (1)
breast cancer	0	3	15009097 (1), 18089809 (1)
tumors	0	21	10896202 (5), 17725108 (4), 15153330 (3), 17496784 (2) (see all 7)
prostate cancer	0	1	17627840 (1)
immunodeficiency	0	1	17444627 (1)

Human Genome Epidemiology (HuGE) Navigator: KAT2B (7 documents)

Export disorders for KAT2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KAT2B gene, integrated from 9 sources (see all 395):
(articles sorted by number of sources associating them with KAT2B)

Utopia: connect your pdf to the dynamic
world of online information

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. (PubMed id 8684459)^{1, 2, 3} Yang X.-J.... Nakatani Y. (1996)
Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. (PubMed id 12486002)^{1, 2, 9} Bres V.... Kiernan R.E. (2002)
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. (PubMed id 11931765)^{1, 2, 9} Mujtaba S.... Zhou M.-M. (2002)
The transcriptional coactivators p300 and CBP are histone acetyltransferases. (PubMed id 8945521)^{1, 2, 9} Ogryzko V.V.... Nakatani Y. (1996)
Steroid receptor coactivator-1 is a histone acetyltransferase. (PubMed id 9296499)^{1, 2, 9} Spencer T.E....O'Malley B.W. (1997)
Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PubMed id 17226766)^{1, 2} Shin S. and Janknecht R. (2007)
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. (PubMed id 17707232)^{1, 2} Zhu P....Rosenfeld M.G. (2007)
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. (PubMed id 15273251)^{1, 2} Zhao Q.... Jane S.M. (2004)
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)^{1, 2} Gangisetty O.... Still I.H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8850	HGNC: 8638	AceView: PCAF	Ensembl:ENSG00000114166	euGenes: HUgn8850
ECgene: KAT2B	Kegg: 8850	H-InvDB: KAT2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KAT2B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KAT2B gene
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Patent Information for KAT2B gene:
Search GeneIP for patents involving KAT2B

GeneCards and IP:
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KAT2B Gene

K(lysine) acetyltransferase 2B

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KAT2B Gene

K(lysine) acetyltransferase 2B

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