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KAT2A Gene(Protein Coding)

Lysine Acetyltransferase 2A

GCID:
GC17M042113
GIFtS:
69
Genes Participants
UDN Logo

Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • Lysine Acetyltransferase 2A 2 3 4
  • K(Lysine) Acetyltransferase 2A 2 3 5
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • Histone Acetyltransferase GCN5 3 4
  • EC 2.3.1.48 4 63
  • HsGCN5 3 4
  • GCN5L2 3 4
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • PCAF-B 3

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Chromatin organization and HTLV-I infection. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is BAZ2A.

UniProtKB/Swiss-Prot for KAT2A Gene

  • Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Gene Wiki entry for KAT2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

Products:

  1. Regulatory Element

Regulatory Elements for KAT2A Gene

Enhancers for KAT2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KAT2A on UCSC Golden Path with GeneCards custom track

Promoters for KAT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KAT2A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KAT2A gene promoter:

Genomic Location for KAT2A Gene

Chromosome:
17
Start:
42,113,108 bp from pter
End:
42,121,393 bp from pter
Size:
8,286 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP, MBIP and WDR5. Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with and acetylates HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Proteomics data for KAT2A Gene at MOPED

Protein Expression for KAT2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KAT2A Gene

Q92830:

Post-translational modifications for KAT2A Gene

  • Ubiquitination at Lys 289 and Lys 446
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KAT2A Gene

Gene Families for KAT2A Gene

HGNC:

Protein Domains for KAT2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Contains 1 bromo domain.
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Domain:
  • Contains 1 bromo domain.
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Enzyme Numbers (IUBMB) for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
GO:0016407 acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with KAT2A: view

Phenotypes for KAT2A Gene

MGI mutant phenotypes for KAT2A:
inferred from 6 alleles
GenomeRNAi human phenotypes for KAT2A:
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Model Products

CRISPR Products

miRNA for KAT2A Gene

miRTarBase miRNAs that target KAT2A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT2A Gene COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for KAT2A Gene

Pathways & Interactions for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8552087
genes like me logo Genes that share ontologies with KAT2A: view

Drugs & Compounds for KAT2A Gene

Products:

  1. Drug

(5) Drugs for KAT2A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
 72-89-9

(3) ApexBio Compounds for KAT2A Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT2A: view

Drug Products

Transcripts for KAT2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KAT2A Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(939) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KAT2A Gene

K(lysine) acetyltransferase 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A
ECgene alternative splicing isoforms for
KAT2A

Expression for KAT2A Gene

Products:

  1. Primer

mRNA expression in normal human tissues for KAT2A Gene

mRNA expression in normal human tissues for KAT2A Gene
mRNA expression by BioGPS for KAT2A GenemRNA expression by GTEx for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2A Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT2A Gene



SOURCE GeneReport for Unigene cluster for KAT2A Gene Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary.
genes like me logo Genes that share expression patterns with KAT2A: view

Protein tissue co-expression partners for KAT2A Gene

Primer Products

No data available for mRNA differential expression in normal tissues for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia KAT2A 35
  • 89.52 (n)
  • 93.96 (a)
KAT2A 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia KAT2A 35
  • 92.79 (n)
  • 98.45 (a)
KAT2A 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Kat2a 35
  • 90.66 (n)
  • 99.21 (a)
Kat2a 16
Kat2a 36
  • 98 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia KAT2A 35
  • 99.52 (n)
  • 99.52 (a)
KAT2A 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Kat2a 35
  • 90.96 (n)
  • 99.08 (a)
oppossum
(Monodelphis domestica)
 Mammalia KAT2A 36
  • 84 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KAT2A 36
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KAT2A 35
  • 83.84 (n)
  • 89.39 (a)
KAT2A 36
  • 89 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia KAT2A 36
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia kat2a 35
  • 76.02 (n)
  • 88.4 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.21330 35
zebrafish
(Danio rerio)
 Actinopterygii kat2a 35
  • 77.41 (n)
  • 88.06 (a)
kat2a 36
  • 84 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004434 35
  • 55.73 (n)
  • 53.02 (a)
fruit fly
(Drosophila melanogaster)
 Insecta Pcaf 35
  • 56.49 (n)
  • 49.73 (a)
Pcaf 36
  • 47 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea pcaf-1 36
  • 30 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GCN5 36
  • 43 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5837 36
  • 56 (a)
 OneToMany
Species with no ortholog for KAT2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

(2) SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Sequence variations from dbSNP and Humsavar for KAT2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs730086 -- 42,119,739(-) TTTAT(C/T)CCCCA intron-variant, upstream-variant-2KB
rs2285657 -- 42,120,576(-) GGGGG(G/T)GTGTG intron-variant, upstream-variant-2KB
rs2074163 -- 42,118,939(-) ACTCT(C/T)CAAGA intron-variant
rs2074164 -- 42,118,220(-) GCTCA(C/G)CTGGG intron-variant
rs2074165 -- 42,115,281(-) AGGCT(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
nsv908240 CNV Loss 21882294
nsv908241 CNV Loss 21882294
dgv3169n71 CNV Loss 21882294
esv2715947 CNV Deletion 23290073

Variation tolerance for KAT2A Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KAT2A Gene

Disorders for KAT2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KAT2A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KAT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KAT2A

Genetic Association Database (GAD)
KAT2A
Human Genome Epidemiology (HuGE) Navigator
KAT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT2A
genes like me logo Genes that share disorders with KAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene

Publications for KAT2A Gene

  1. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R. … Berger S.L. (Mol. Cell. Biol. 1996) 2 3 4 67
  2. A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. (PMID: 20224553) Lee H.S. … Kwon J. (EMBO J. 2010) 3 23
  3. GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. (PMID: 15715965) Kikuchi H. … Nakayama T. (Gene 2005) 3 23
  4. BAF53 forms distinct nuclear complexes and functions as a critical c- Myc-interacting nuclear cofactor for oncogenic transformation. (PMID: 11839798) Park J. … Cole M.D. (Mol. Cell. Biol. 2002) 3 23
  5. Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. (PMID: 12391296) Poux A.N. … Marmorstein R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23

Products for KAT2A Gene

  • Addgene plasmids for KAT2A

Sources for KAT2A Gene

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