Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Suite
- Affiliated Databases
  
  Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

KAT2A Gene

protein-coding GIFtS: 68
GCID: GC17M040265

K(Lysine) Acetyltransferase 2A

(Previous name: GCN5 general control of amino-acid synthesis 5-like 2 (yeast))
(Previous symbol: GCN5L2)

See KAT2A-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
K(Lysine) Acetyltransferase 2A¹ ²		PCAF-b²
GCN5L2¹ ² ³ ⁵		GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2²
GCN5² ³ ⁵		General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2²
General Control Of Amino Acid Synthesis Protein 5-Like 2² ³		hGCN5²
Histone Acetyltransferase GCN5² ³		Histone Acetyltransferase KAT2A²
Lysine Acetyltransferase 2A² ³		hsGCN5²
STAF97² ³		HGCN5³
EC 2.3.1.48³ ⁸		HsGCN5³
GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast)¹

External Ids:	HGNC: 4201¹	Entrez Gene: 2648²	Ensembl: ENSG00000108773⁷	OMIM: 602301⁵	UniProtKB: Q92830³

Export aliases for KAT2A gene to outside databases

Previous GC identifers: GC17M037519 GC17M036030

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KAT2A Gene:

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It

also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B

subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).(supplied by OMIM, Sep

2009)

GeneCards Summary for KAT2A Gene:

KAT2A (K(lysine) acetyltransferase 2A) is a protein-coding gene. Diseases associated with KAT2A include dosage-sensitive sex reversal. GO annotations related to this gene include histone deacetylase binding and chromatin binding. An important paralog of this gene is BAZ1A.

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830

Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of

histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase

activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited

by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of

proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3

and H4

Gene Wiki entry for KAT2A (GCN5L2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000017.10 NT_010783.16 NC_018928.2

Regulatory elements:

Regulatory transcription factor binding sites in the KAT2A gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta STAT5A Egr-4 STAT1alpha STAT2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KAT2A promoter sequence

Search Chromatin IP Primers for KAT2A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KAT2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21

KAT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT2A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M040265: view genomic region (about GC identifiers)

Start:	40,265,126 bp from pter	End:	40,273,382 bp from pter
Size:	8,257 bases	Orientation:	minus strand

1 alternative location:

Chr17-,NW_003571052 399,753-408,006

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 (See protein sequence)

Recommended Name: Histone acetyltransferase KAT2A

Size: 837 amino acids; 93926 Da

Subunit: Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L,

TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP.

Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H,

KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated

with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with and

acetylates HIV-1 Tat. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L,

TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP,

MBIP and WDR5. Interacts with PML (By similarity)

3 PDB 3D structures from and Proteopedia for KAT2A:

1F68 (3D)

1Z4R (3D)

3D7C (3D)

Secondary accessions: Q8N1A2 Q9UCW1

Alternative splicing: 2 isoforms: Q92830-1 Q92830-2

Explore the universe of human proteins at neXtProt for KAT2A: NX_Q92830

Explore proteomics data for KAT2A at MOPED

Post-translational modifications:

Ubiquitination² at Lys289, Lys446

Modification sites at PhosphoSitePlus

2 DME Specific Peptides for KAT2A (Q92830)

EQVKGYGT

YAIGYFKKQGF

See KAT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066564.2

ENSEMBL proteins:

ENSP00000225916 ENSP00000468390 ENSP00000467324

Reactome Protein details: Q92830

KAT2A Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for KAT2A
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for KAT2A OriGene Custom MassSpec OriGene Custom Protein Services for KAT2A
	GenScript Custom Purified and Recombinant Proteins Services for KAT2A
	Novus Biologicals KAT2A Proteins
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for KAT2A
	Cloud-Clone Corp. Proteins for KAT2A
	Search eBioscience for Proteins for KAT2A
	Search GeneTex for Proteins for KAT2A
	antibodies-online proteins for KAT2A (7 products)
	antibodies-online peptides for KAT2A

KAT2A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KAT2A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KAT2A (GCN5)
	OriGene Antibodies for KAT2A OriGene Custom Antibody Services for KAT2A
	Novus Biologicals KAT2A Antibodies
	Abcam antibodies for KAT2A
	Cloud-Clone Corp. Antibodies for KAT2A
	ThermoFisher Antibody for KAT2A
	antibodies-online antibodies for KAT2A (71 products)

KAT2A Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KAT2A
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KAT2A
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KAT2A Cloud-Clone Corp. CLIAs for KAT2A
	Search eBioscience for ELISAs for KAT2A
	antibodies-online kits for KAT2A (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

KAT: Chromatin-modifying enzymes / K-acetyltransferases

Selected InterPro protein domains (see all 6):

IPR009464 PCAF_N

IPR000182 GNAT_dom

IPR018359 Bromodomain_CS

IPR016376 Hist_acetylase_PCAF

IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry Q92830

ProtoNet protein and cluster: Q92830

2 Blocks protein domains:

IPB001487 Bromodomain signature

IPB009464 PCAF

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830

Similarity: Belongs to the acetyltransferase family. GCN5 subfamily

Similarity: Contains 1 bromo domain

Similarity: Contains 1 N-acetyltransferase domain

Find genes that share domains with KAT2A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KAT2A_HUMAN, Q92830

Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of

histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase

activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited

by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of

proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3

and H4

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Enzyme Number (IUBMB): EC 2.3.1.48¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0003713	transcription coactivator activity	IDA	11564863
GO:0004402	contributes to histone acetyltransferase activity	IDA	11564863
GO:0005515	protein binding	IPI	17664281
GO:0008080	N-acetyltransferase activity	--	--

Find genes that share ontologies with KAT2A About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for KAT2A:

Decreased p24 protein expressi

12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Kat2a):

behavior/neurological	cardiovascular system	cellular	craniofacial	embryogenesis
growth/size/body	mortality/aging	nervous system	normal	respiratory system
skeleton	vision/eye

Find genes that share phenotypes with KAT2A About GenesLikeMe

Animal Models:
MGI mouse knock-outs for KAT2A: Kat2a^tm1Nkt Kat2a^tm3.1Roth

genOway: Develop your customized and physiologically relevant rodent model for KAT2A

miRNA Products:		miRTarBase miRNAs that target KAT2A: hsa-mir-615-3p (MIRT039857), hsa-mir-17-5p (MIRT050843), hsa-mir-331-3p (MIRT043446), hsa-mir-92a-3p (MIRT049612), hsa-mir-124-3p (MIRT022532), hsa-mir-1 (MIRT023698), hsa-mir-183-5p (MIRT047064)

		Block miRNA regulation of human, mouse, rat KAT2A using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate KAT2A:
		hsa-miR-365 hsa-miR-550a hsa-miR-637 hsa-miR-122 hsa-miR-155 hsa-miR-3652
		SwitchGear 3'UTR luciferase reporter plasmid: KAT2A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KAT2A
		Predesigned siRNA for gene silencing in human, mouse, rat KAT2A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KAT2A

Clone Products:		OriGene clones in human, mouse for KAT2A (see all 6) OriGene ORF clones in mouse, rat for KAT2A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KAT2A (NM_021078)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT2A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT2A
		Addgene plasmids for KAT2A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KAT2A
		Browse ESI BIO Cell Lines and PureStem Progenitors for KAT2A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

KAT2A_HUMAN, Q92830: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytoskeleton	2
cytosol	2

About this image

Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000123	histone acetyltransferase complex	--	--
GO:0005615	extracellular space	IDA	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386

Find genes that share ontologies with KAT2A About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for KAT2A About (see all 18)

See pathways by source

Powered
by

SuperPath

Selected contained pathways About (see all per SuperPath)

Notch signaling pathway (KEGG)

Notch signaling pathway

0.84

Notch Signaling Pathway

0.84

Signaling by NOTCH1 PEST Domain Mutants in Cancer

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.79	Signaling by NOTCH1 in Cancer	0.79
Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.79	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.79
Signaling by NOTCH1 HD Domain Mutants in Cancer	0.79	FBXW7 Mutants and NOTCH1 in Cancer	0.79
Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant	0.79	NOTCH1 Intracellular Domain Regulates Transcription	0.68

RNA Polymerase I Promoter Opening

RNA Polymerase I Transcription	0.78	Chromatin organization	0.34
RNA Polymerase I Promoter Clearance	0.78	Chromatin modifying enzymes	0.34
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.73	HATs acetylate histones	0.34

Pre-NOTCH Expression and Processing

	Pre-NOTCH Expression and Processing	0.62			Notch-HLH transcription pathway	0.00
	Pre-NOTCH Transcription and Translation	0.62

Gene Expression

Gene Expression

0.40

Generic Transcription Pathway

0.40

Find genes that share SuperPaths with KAT2A About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for KAT2A

Notch Signaling Pathways

1 Cell Signaling Technology (CST) Pathway for KAT2A

Chromatin Regulation / Acetylation

1 GeneGo (Thomson Reuters) Pathway for KAT2A

Development Notch Signaling Pathway

5 BioSystems Pathways for KAT2A

	Notch Signaling Pathway
	E2F transcription factor network
	Regulation of nuclear SMAD2/3 signaling
	C-MYC pathway
	Validated targets of C-MYC transcriptional activation

Selected Reactome Pathways for KAT2A (see all 7)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH1 Intracellular Domain Regulates Transcription
	HATs acetylate histones
	Pre-NOTCH Transcription and Translation
	Notch-HLH transcription pathway

4 Kegg Pathways (Kegg details for KAT2A):

	Notch signaling pathway
	Thyroid hormone signaling pathway
	HTLV-I infection
	Viral carcinogenesis

Pathway & Disease-focused RT² Profiler PCR Arrays including KAT2A:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Stem Cells in human mouse rat

Interactions:

GeneGlobe Interaction Network for KAT2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for KAT2A (Q92830^{1, 2, 3} ENSP00000225916⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 368)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4F	P62805³, ENSP00000366974⁴	I2D: score=1 STRING: ENSP00000366974
HIST1H4H	P62805³, ENSP00000289352⁴	I2D: score=1 STRING: ENSP00000289352
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001756	somitogenesis	IEA	--
GO:0001843	neural tube closure	IEA	--
GO:0006325	chromatin organization	TAS	--
GO:0006338	chromatin remodeling	TAS	8552087

Find genes that share ontologies with KAT2A About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KAT2A

2 HMDB Compounds for KAT2A About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--

1 DrugBank Compound for KAT2A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coenzyme A	--	85-61-0	target	--	10592235

1 Novoseek inferred chemical compound relationship for KAT2A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	52.3	3	17760996 (1), 18480452 (1), 19940161 (1)

Find genes that share compounds with KAT2A About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for KAT2A gene (3 alternative transcripts):

NM_021078.2 XM_006721817.1 XM_006721818.1

Unigene Cluster for KAT2A:

K(lysine) acetyltransferase 2A

Hs.463045 [show with all ESTs]

Unigene Representative Sequence: NM_021078

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000225916(uc002hyx.2) ENST00000465682 ENST00000586972 ENST00000588759

ENST00000592310

miRNA Products:		Block miRNA regulation of human, mouse, rat KAT2A using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate KAT2A:
		hsa-miR-365 hsa-miR-550a hsa-miR-637 hsa-miR-122 hsa-miR-155 hsa-miR-3652
		SwitchGear 3'UTR luciferase reporter plasmid: KAT2A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KAT2A
		Predesigned siRNA for gene silencing in human, mouse, rat KAT2A

Clone Products:		OriGene clones in human, mouse for KAT2A (see all 6) OriGene ORF clones in mouse, rat for KAT2A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KAT2A (NM_021078)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KAT2A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT2A
		Addgene plasmids for KAT2A

Primer Products:		OriGene qPCR primer pairs and template standards for KAT2A OriGene qSTAR qPCR primer pairs in human, mouse for KAT2A
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat KAT2A
		QuantiTect SYBR Green Assays in human, mouse, rat KAT2A
		QuantiFast Probe-based Assays in human, mouse, rat KAT2A

Additional mRNA sequence:

AF029777.1 BC032743.1 BC039907.1 BC105977.1

11 DOTS entries:

DT.100782516 DT.101976634 DT.454032 DT.100782517 DT.120956925 DT.120957022 DT.120956933 DT.97847268

DT.91982305 DT.92439173 DT.92024500

Selected AceView cDNA sequences (see all 939):

BU528928 T16918 R73950 AW071488 CR612483 AL702429 AF498938 AA304768

AI520757 BI554166 BU148795 AI300457 AV703361 BE045640 BC032743 CR603551

CR591906 BE350297 BE676475 BM554081 AI361665 BE901116 BF436764 AI467843

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19a	·	19b
SP1:													-
SP2:
SP3:																													-		-
SP4:
SP5:

ECgene alternative splicing isoforms for KAT2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KAT2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTTGTCCAG

About this image

KAT2A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Ovary (Reproductive System)

Adrenal Gland (Endocrine System)

KAT2A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KAT2A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.463045

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830

Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary

Pathway & Disease-focused RT² Profiler PCR Arrays including KAT2A:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for KAT2A OriGene qSTAR qPCR primer pairs in human, mouse for KAT2A
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat KAT2A
		QuantiTect SYBR Green Assays in human, mouse, rat KAT2A
		QuantiFast Probe-based Assays in human, mouse, rat KAT2A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kat2a^{1 , 5}	K(lysine) acetyltransferase 2A^{1, 5}	90.66(n)¹ 99.21(a)¹		11 (63.53 cM)⁵ 14534¹ NM_001038010.2¹ NP_001033099.1¹ 100704746⁵
chicken (Gallus gallus)	Aves	KAT2A¹	K(lysine) acetyltransferase 2A	83.84(n) 89.39(a)		374232 XM_004948645.1 XP_004948702.1
lizard (Anolis carolinensis)	Reptilia	KAT2A⁶	K(lysine) acetyltransferase 2A	80(a)	1 ↔ 1	6(72877634-72901955)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21330²	Xenopus laevis transcribed sequence with strong similarity to protein refNP_066564.1 (H.sapiens) GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; hGCN5; General control less	76.13(n)		BJ072879.1
zebrafish (Danio rerio)	Actinopterygii	kat2a¹	K(lysine) acetyltransferase 2A	77.41(n) 88.06(a)		555517 XM_001922697.4 XP_001922732.1
fruit fly (Drosophila melanogaster)	Insecta	Pcaf¹	Pcaf	56.49(n) 49.73(a)		39431 NM_140329.3 NP_648586.2
worm (Caenorhabditis elegans)	Secernentea	pcaf-1⁶	Protein PCAF-1 (pcaf-1) mRNA, complete cds	30(a)	many ↔ many	I(3516478-3523387) WBGene00021636
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCN5⁶	Acetyltransferase, modifies N-terminal lysines on ...	43(a)	1 → many	VII(996869-998188) YGR252W

ENSEMBL Gene Tree for KAT2A (if available)
TreeFam Gene Tree for KAT2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for KAT2A gene

BAZ1A² BPTF² BAZ2B² CECR2² BAZ2A² BAZ1B² KAT2B²

2 SIMAP similar genes for KAT2A using alignment to 3 protein entries: KAT2A_HUMAN (see all proteins):

KAT2B BPTF

Find genes that share paralogs with KAT2A About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17659391^1,2	C,F,H	--	40266939(+)	`GGACAG/ACTCCG`	2	/L	syn¹ ese³		13		NA NS EA EU	6633
rs144813806^1,2	F	--	40266982(+)	`ATCAGC/TGTCGC`	2	T	syn¹		1		NA	4552
rs151266449^1,2	C	--	40267087(+)	`CATCCA/GTAAGT`	1	--	int¹		0	--	--	--	--
rs77336254^1,2	C,F	--	40267110(+)	`CTGTCG/ATCCCT`	1	--	int¹		1		WA	118
rs140505457^1,2		--	40267178(+)	`TCCTCC/TTGGGG`	1	--	int¹		0	--	--	--	--
rs186655063^1,2		--	40267249(+)	`ATCCCA/GAAGAG`	1	--	int¹		0	--	--	--	--
rs2074166^1,2	C,F,A,H	--	40267255(-)	`GGGGGA/GCTCTT`	1	--	int¹		21		EA NS NA WA CSA	2781
rs2074165^1,2	C,F,A	--	40267299(-)	`AGGCTG/AGAGGA`	1	--	int¹		6		NA WA CSA	11
rs145017118^1,2		--	40267529(+)	`CCCCAA/GTTCCT`	1	--	int¹		0	--	--	--	--
rs191356084^1,2		--	40267557(+)	`CCCCAC/TAGGCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KAT2A (40265126 - 40273382 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for KAT2A: About this table

Variant ID	Type	Subtype	PubMed ID
esv2715947	CNV	Deletion	23290073
dgv3169n71	CNV	Loss	21882294
nsv908241	CNV	Loss	21882294
nsv908240	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KAT2A

DNA2.0 Custom Variant and Variant Library Synthesis for KAT2A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 602301 OMIM disorders: --

1 disease for KAT2A:
About MalaCards

dosage-sensitive sex reversal

Find genes that share disorders with KAT2A About GenesLikeMe

Genetic Association Database (GAD): KAT2A
Human Genome Epidemiology (HuGE) Navigator: KAT2A (1 document)

Export disorders for KAT2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KAT2A gene, integrated from 10 sources (see all 151):
(articles sorted by number of sources associating them with KAT2A)

Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087)^{1, 2, 3} Candau R....Berger S.L. (Mol. Cell. Biol. 1996)
The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PubMed id 11384967)^{1, 2, 9} Col E....Khochbin S. (J. Biol. Chem. 2001)
Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PubMed id 9611240)^{1, 2, 9} Smith E.R.... Allis C.D. (Nucleic Acids Res. 1998)
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)^{1, 2} Zhao Y.... Devys D. (Mol. Cell 2008)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)^{1, 2} Gangisetty O.... Still I.H. (Oncogene 2004)
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)^{1, 2} Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)^{1, 2} Gangloff Y.G.... Davidson I. (Mol. Cell. Biol. 2001)
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234)^{1, 2} McMahon S.B.... Cole M.D. (Mol. Cell. Biol. 2000)
Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. (PubMed id 11090279)^{1, 2} Hudson B.P.... Wright P.E. (J. Mol. Biol. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2648	HGNC: 4201	AceView: RAB5CandGCN5L2	Ensembl:ENSG00000108773	euGenes: HUgn2648
ECgene: KAT2A	Kegg: 2648	H-InvDB: KAT2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KAT2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KAT2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KAT2A gene:
Search GeneIP for patents involving KAT2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KAT2A
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for KAT2A		OriGene RNAi products in human, mouse, rat for KAT2A
	OriGene qPCR primer pairs and template standards for KAT2A		OriGene Protein Over-expression Lysate for KAT2A
	OriGene Custom Mass Spec		OriGene clones in human, mouse for KAT2A
	OriGene qSTAR qPCR primer pairs in human, mouse for KAT2A		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for KAT2A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KAT2A		OriGene Custom Protein Services for KAT2A

	Block miRNA regulation of human, mouse, rat KAT2A using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing KAT2A
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KAT2A		Predesigned siRNA for gene silencing in human, mouse, rat KAT2A
	QuantiFast Probe-based Assays in human, mouse, rat KAT2A		QuantiTect SYBR Green Assays in human, mouse, rat KAT2A
	PCR Arrays including human, mouse, rat KAT2A		Search Chromatin IP Primers for KAT2A
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat KAT2A		GeneGlobe Interaction Network for KAT2A
	Regulatory tfbs in KAT2A promoter

	GenScript Custom Purified and Recombinant Proteins Services for KAT2A		GenScript cDNA clones with any tag delivered in your preferred vector for KAT2A
	GenScript Custom Assay Services for KAT2A		GenScript Custom overexpressing Cell Line Services for KAT2A
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Antibodies & Assays for KAT2A (GCN5)

Search Tocris compounds for KAT2A

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

	Proteins for KAT2A
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KAT2A antibodies
	KAT2A proteins

	Antibodies for KAT2A
	See all of Abcam's Antibodies, Kits and Proteins for KAT2A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for KAT2A

	Proteins for KAT2A
	Antibodies for KAT2A
	ELISAs for KAT2A
	CLIAs for KAT2A

Browse ESI BIO Cell Lines and PureStem Progenitors for KAT2A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2A

	SwitchGear 3'UTR luciferase reporter plasmids for KAT2A
	SwitchGear Promoter luciferase reporter plasmids for KAT2A

ThermoFisher Antibody for KAT2A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KAT2A

Browse compounds at ApexBio

Addgene plasmids for KAT2A

	Search eBioscience for proteins for KAT2A
	Search eBioscience for elisas for KAT2A
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for KAT2A

	antibodies-online antibodies for KAT2A (71 products)
	antibodies-online kits for KAT2A (4 products)
	antibodies-online peptides for KAT2A
	antibodies-online proteins for KAT2A (7 products)

Search GeneTex for proteins for KAT2A

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KAT2A gene at Home site.

Version: 3.12.350 1 Mar 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Suite

Advanced Search

Export list of displayed genes

KAT2A Gene

K(Lysine) Acetyltransferase 2A

Aliases
for KAT2A gene

Summaries
for KAT2A gene

Genomic Views
for KAT2A gene

Proteins
for KAT2A gene

KAT2A Human Recombinant Protein Products:

KAT2A Antibody Products:

KAT2A Assay Products:

Domains /
Families
for KAT2A gene

Function
for KAT2A gene

Localization
for KAT2A gene

Pathways & Interactions
for KAT2A gene

Drugs & Compounds
for KAT2A gene

Transcripts
for KAT2A gene

Expression
for KAT2A gene

Orthologs
for KAT2A gene

Paralogs
for KAT2A gene

Genomic Variants
for KAT2A gene

Disorders / Diseases
for KAT2A gene

Publications
for KAT2A gene

External Searches for KAT2A gene

Genome Databases showing KAT2A gene

Other Databases showing KAT2A gene

Specialized Databases showing KAT2A gene

Intellectual Property
for KAT2A gene

Products
for KAT2A gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

KAT2A Gene

K(Lysine) Acetyltransferase 2A

Aliasesfor KAT2A gene

Summariesfor KAT2A gene

Genomic Viewsfor KAT2A gene

Proteinsfor KAT2A gene

KAT2A Human Recombinant Protein Products:

KAT2A Antibody Products:

KAT2A Assay Products:

Domains /Familiesfor KAT2A gene

Functionfor KAT2A gene

Localizationfor KAT2A gene

Pathways & Interactionsfor KAT2A gene

Drugs & Compoundsfor KAT2A gene

Transcriptsfor KAT2A gene

Expression for KAT2A gene

Orthologsfor KAT2A gene

Paralogsfor KAT2A gene

Genomic Variantsfor KAT2A gene

Disorders / Diseasesfor KAT2A gene

Publicationsfor KAT2A gene

External Searches for KAT2A gene

Genome Databases showing KAT2A gene

Other Databases showing KAT2A gene

Specialized Databases showing KAT2A gene

Intellectual Propertyfor KAT2A gene

Productsfor KAT2A gene

View Random Gene

Aliases
for KAT2A gene

Summaries
for KAT2A gene

Genomic Views
for KAT2A gene

Proteins
for KAT2A gene

Domains /
Families
for KAT2A gene

Function
for KAT2A gene

Localization
for KAT2A gene

Pathways & Interactions
for KAT2A gene

Drugs & Compounds
for KAT2A gene

Transcripts
for KAT2A gene

Expression
for KAT2A gene

Orthologs
for KAT2A gene

Paralogs
for KAT2A gene

Genomic Variants
for KAT2A gene

Disorders / Diseases
for KAT2A gene

Publications
for KAT2A gene

Intellectual Property
for KAT2A gene

Products
for KAT2A gene