KAT2A Gene protein-coding GIFtS : 66 GCID: GC17 M040265
K(Lysine) Acetyltransferase 2A GCN5 general control of amino-acid synthesis 5-like 2 (yeast) )GCN5L2 )
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Aliasesfor KAT2A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases K(Lysine) Acetyltransferase 2A 1 2 PCAF-b2 GCN5L21 2 3 5 GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 22 GCN52 3 5 General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 22 General Control Of Amino Acid Synthesis Protein 5-Like 22 3 hGCN52 Histone Acetyltransferase GCN52 3 Histone Acetyltransferase KAT2A2 Lysine Acetyltransferase 2A2 3 hsGCN52 STAF972 3 HGCN53 EC 2.3.1.483 8 HsGCN53 GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast)1
Export aliases for KAT2A gene to outside databases Previous GC identifers: GC17M037519 GC17M036030
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Summariesfor KAT2A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KAT2A Gene: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. Italso functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-Bsubunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).(supplied by OMIM, Sep2009) GeneCards Summary for KAT2A Gene: KAT2A (K(lysine) acetyltransferase 2A) is a protein-coding gene. Diseases associated with KAT2A include retinal degeneration cystic fibrosis related super-pathways are Notch Signaling Pathway and Constitutive Signaling by NOTCH1 PEST Domain Mutants . GO annotations related to this gene include histone deacetylase binding and chromatin binding . An important paralog of this gene is BAZ1A . UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 Function : Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation ofhistones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferaseactivity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruitedby the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling ofproviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3and H4 Gene Wiki entry for KAT2A (GCN5L2) Gene
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Genomic Viewsfor KAT2A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NT_010783.15 NC_018928.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KAT2A gene promoter:STAT5B STAT1 STAT4 STAT6 STAT1beta STAT5A Egr-4 STAT1alpha STAT2 STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for KAT2A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21 KAT2A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M040265: view genomic region
(about GC identifiers )
Start: 40,265,126 bp from pter End:
40,273,382 bp from pter
Size: 8,257 bases Orientation:
minus strand
1 alternative location : Chr 17-,NW_003571052 399,753-408,006
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Proteinsfor KAT2A gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 See
protein sequence )Recommended Name: Size : 837 amino acids; 93926 DaSubunit : Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L,TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP.Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H,KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associatedwith a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with andacetylates HIV-1 Tat. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L,TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP,MBIP and WDR5. Interacts with PML (By similarity)
Subcellular location : Nucleus3 PDB 3D structures from :1F68 (3D) 1Z4R (3D) 3D7C (3D) Secondary accessions : Q8N1A2 Q9UCW1Alternative splicing : 2 isoforms : Q92830-1 Q92830-2 Explore the universe of human proteins at neXtProt for KAT2A: NX_Q92830 Explore proteomics data for KAT2A at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q92830 2 DME Specific Peptides for KAT2A (Q92830 ) KAT2A Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_066564.2 ENSEMBL proteins: ENSP00000225916 ENSP00000468390 ENSP00000467324 Reactome Protein details: Q92830 Human Recombinant Protein Products for KAT2A: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing KAT2A Antibody Products: Assay Products for KAT2A:
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Protein
Domains /for KAT2A gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: KAT: Chromatin-modifying enzymes / K-acetyltransferases 5/6 InterPro protein domains (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q92830 ProtoNet protein and cluster: Q92830
2 Blocks protein domains : IPB001487 IPB009464 UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 Similarity : Belongs to the GCN5 familySimilarity : Contains 1 bromo domainSimilarity : Contains 1 N-acetyltransferase domainAbout GeneDecksing
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Functionfor KAT2A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: KAT2A_HUMAN, Q92830 Function : Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation ofhistones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferaseactivity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruitedby the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling ofproviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3and H4 Catalytic activity : Acetyl-CoA + [histone] = CoA + acetyl-[histone] Enzyme Number (IUBMB): EC 2.3.1.48 1 2
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for KAT2A :12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Kat2a) :About GeneDecksing Animal Models: MGI mouse knock-outs for KAT2A: Kat2a tm3.1Roth Kat2a tm1Nkt Cell Line GenScript Custom overexpressing Cell Line Services for KAT2A Search LifeMap BioReagents cell lines for KAT2A In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2A
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Pathways & Interactionsfor KAT2A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for KAT2A About (see all 16 ) See pathways by source SuperPath Selected contained pathways About (see all per SuperPath ) 1 Notch signaling pathway 2 Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant 3 Generic Transcription Pathway 4 NOTCH2 intracellular domain regulates transcription 5 Signaling by GPCR
Pathways by source See SuperPaths Show all pathways 2 1 1 1 5 5/17 (see all 17 )3 (Kegg details for KAT2A) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KAT2A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/214 Interacting proteins for KAT2A (Q92830 1 , 2 , 3 ENSP00000225916 4 via UniProtKB, MINT, STRING , and/or I2D (see all 214 )About this table Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21 ): About this table
About GeneDecksing
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Drugs & Compoundsfor KAT2A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for KAT2A 2 HMDB Compounds for KAT2A About this table 1 DrugBank Compound for KAT2A About this table 1 Novoseek inferred chemical compound relationship for KAT2A gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
lysine
52.3
3
17760996 (1), 18480452 (1), 19940161 (1)
KAT2A
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Transcriptsfor KAT2A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KAT2A gene: NM_021078.2 Unigene Cluster for KAT2A:
K(lysine) acetyltransferase 2A Hs.463045 [show with all ESTs ] Unigene Representative Sequence: NM_021078 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000225916 (uc002hyx.2 ) ENST00000465682 ENST00000586972 ENST00000588759 ENST00000592310 Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 Primer KAT2A human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AF029777.1 BC032743.1 BC039907.1 BC105977.1
11 DOTS entries : DT.100782516 DT.101976634
DT.454032 DT.100782517 DT.120956925 DT.120957022 DT.120956933 DT.97847268 DT.91982305 DT.92439173 DT.92024500 24/939 AceView cDNA sequences (see all 939 ):
CD367703 CR624854 BM856818 BG910375 BQ723274 CB995288 AI440062 BU508647 BP364342 CR595680 AI188734 BM563618 CR617757 AI272124 BQ897177 BM829325 BM551506 AI361665 BG231732 CR623581 BQ879580 BQ229685 T16918 AI445906 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b SP1 : - SP2 : SP3 : - - SP4 : SP5 :
ECgene alternative splicing isoforms for KAT2A
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Expression for KAT2A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KAT2A expression in normal human tissues
(normalized intensities) KAT2A embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CCTTGTCCAGAbout this image
KAT2A expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/1 selected tissues (see all 1 ) fully expand Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries Myoblasts Mandibular Arch Muscles
See KAT2A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KAT2A SOURCE GeneReport for Unigene cluster: Hs.463045 UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 Tissue specificity : Expressed in all tissues tested, with most abundant expression in ovarySABiosciences Expression via Pathway-Focused PCR Arrays including KAT2A : Primer KAT2A human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KAT2A
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Orthologsfor KAT2A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KAT2A gene from 10/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Kat2a1 5
K(lysine) acetyltransferase 2A1, 5
90.67(n) 1 98.19(a) 1
11 (63.53 cM) 5 14534 1 NM_020004.5 1 NP_064388.2 1 100704746 5
chicken Aves KAT2A1
K(lysine) acetyltransferase 2A
82.35(n) 88.02(a)
374232 NM_204329.1 NP_989660.1
lizard Reptilia KAT2A6
K(lysine) acetyltransferase 2A
81(a)
1 ↔ 1
6(72877634-72901955)
African clawed frog Amphibia Xl.213302
Xenopus laevis transcribed sequence with strong similarity to protein refNP_066564.1 (H.sapiens) GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; hGCN5; General control less
76.13(n)
BJ072879.1
zebrafish Actinopterygii kat2a1
K(lysine) acetyltransferase 2A
76.49(n) 86.62(a)
555517 XM_001922697.3 XP_001922732.1
fruit fly Insecta Pcaf1
CG4107-PA
56.06(n) 49.61(a)
39431 NM_140329.3 NP_648586.2
worm Secernentea pcaf-11
Protein PCAF-1
43.38(n) 34.43(a)
171920 NM_058772.5 NP_491173.1
baker's yeast Saccharomycetes GCN56
Acetyltransferase, modifies N-terminal lysines on ... 42(a)
1 → many
VII(996869-998188)
thale cress eudicotyledons HAG11
histone acetyltransferase GCN5
51.06(n) 45.09(a)
824626 NM_115318.2 NP_567002.1
rice Liliopsida Os10g04159001
hypothetical protein
48.4(n) 42.47(a)
4348629 NM_001071139.1 NP_001064604.1
ENSEMBL Gene Tree for KAT2A (if available)TreeFam Gene Tree for KAT2A (if available)
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Paralogsfor KAT2A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KAT2A gene BAZ1A 2 BPTF 2 BAZ2B 2 CECR2 2 BAZ2A 2 BAZ1B 2 KAT2B 2 2 SIMAP similar genes for KAT2A using alignment to 3 protein entries: KAT2A_HUMAN (see all proteins ):KAT2B BPTF About GeneDecksing
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Genomic Variantsfor KAT2A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KAT2A (40265126 - 40273382 bp)
Structural Variations Database of Genomic Variants (DGV) 4 variations for KAT2A : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KAT2A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 602301
OMIM disorders : --8 : About MalaCards retinal degeneration cystic fibrosis retinitis acute lymphoblastic leukemia lymphoblastic leukemia thyroiditis breast cancer leukemia About GeneDecksing Genetic Association Database (GAD): KAT2A Human Genome Epidemiology (HuGE) Navigator: KAT2A (1 document)Export disorders for KAT2A gene to outside databases
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Publicationsfor KAT2A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KAT2A gene, integrated from 9 sources (see all 148 ):(articles sorted by number of sources associating them with KAT2A) Utopia : connect your pdf to the dynamic
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087) 1 , 2 , 3(1996) The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PubMed id 11384967) 1 , 2 , 9(2001) Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PubMed id 9611240) 1 , 2 , 9(1998) A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972) 1 , 2 (2008) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 1 , 2 (2005) The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476) 1 , 2 (2004) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863) 1 , 2 (2001) The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666) 1 , 2 (2001) The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234) 1 , 2 (2000) Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. (PubMed id 11090279) 1 , 2 (2000)
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Genome Databases showing KAT2A gene
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Specialized Databases showing KAT2A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for KAT2A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KAT2A gene: KAT2A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KAT2A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KAT2A QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for KAT2A (GCN5)
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KAT2A
LSBio Antibodies in human mouse rat
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