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Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • Lysine Acetyltransferase 2A 2 3 4 5
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • K(Lysine) Acetyltransferase 2A 2 3
  • Histone Acetyltransferase GCN5 3 4
  • EC 2.3.1.48 4 61
  • HsGCN5 3 4
  • GCN5L2 3 4
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • Histone Acetyltransferase KAT2A 3
  • PCAF-B 3

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and HTLV-I infection. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.

UniProtKB/Swiss-Prot for KAT2A Gene

  • Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Gene Wiki entry for KAT2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

Regulatory Elements for KAT2A Gene

Enhancers for KAT2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F042386 1.2 ENCODE 30.3 -267.1 -267055 4.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000267002 KAT2A ENSG00000267340 HSD17B1 PTRF NBR1 LOC108783654 STAT3 P3H4 ENSG00000267765
GH17F042392 0.9 ENCODE 33 -271.6 -271600 0.9 HDGF ZNF493 ZFP64 YY1 ZNF302 ZNF354C ZNF138 ZNF202 ZNF680 ZNF654 ENSG00000267340 ENSG00000267002 HMGN1P29 KAT2A LOC108783654 ENSG00000267758 NBR2 P3H4 ENSG00000267765 LINC00910
GH17F041518 1.8 FANTOM5 Ensembl ENCODE 13.9 +596.1 596139 13.6 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000259623 KAT2A KRT19 P3H4 DHX58 KRT36 KRT14 ENSG00000267758 STAT5B LOC100505782
GH17F042419 1.5 FANTOM5 ENCODE 15.1 -300.6 -300551 5.2 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF416 ENSG00000267002 LINC00910 ENSG00000267340 KAT2A HMGN1P29 TUBG2 NAGLU MIR5010 ATP6V0A1 DHX58
GH17F042515 1.7 FANTOM5 Ensembl ENCODE 12.3 -400.5 -400500 12.2 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000267340 MLX TUBG2 ENSG00000267002 PTRF NAGLU RAB5C KAT2A MIR5010 ATP6V0A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KAT2A on UCSC Golden Path with GeneCards custom track

Promoters for KAT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346472 293 1001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 YY2

Genomic Location for KAT2A Gene

Chromosome:
17
Start:
42,113,108 bp from pter
End:
42,121,393 bp from pter
Size:
8,286 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT14, MBIP and WDR5. Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with and acetylates HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Selected DME Specific Peptides for KAT2A Gene

Q92830:
  • YAIGYFKKQGF
  • EQVKGYGT

Post-translational modifications for KAT2A Gene

  • Ubiquitination at Lys 289 and Lys 446
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT2A (GCN5)

Domains & Families for KAT2A Gene

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Contains 1 bromo domain.
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Domain:
  • Contains 1 bromo domain.
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Enzyme Numbers (IUBMB) for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 histone acetyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 17664281
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with KAT2A: view
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2A

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with KAT2A: view

Pathways & Interactions for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0006338 chromatin remodeling TAS 8552087
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KAT2A: view

Drugs & Compounds for KAT2A Gene

(5) Drugs for KAT2A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for KAT2A Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT2A: view

Drug Products

Transcripts for KAT2A Gene

Unigene Clusters for KAT2A Gene

K(lysine) acetyltransferase 2A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A
ECgene alternative splicing isoforms for
KAT2A

Expression for KAT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2A Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT2A Gene



Protein tissue co-expression partners for KAT2A Gene

NURSA nuclear receptor signaling pathways regulating expression of KAT2A Gene:

KAT2A

SOURCE GeneReport for Unigene cluster for KAT2A Gene:

Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene:

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary.
genes like me logo Genes that share expression patterns with KAT2A: view

No data available for mRNA differential expression in normal tissues for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT2A 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia KAT2A 34 35
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Kat2a 34
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Kat2a 34 16 35
  • 90.66 (n)
cow
(Bos Taurus)
Mammalia KAT2A 34 35
  • 89.52 (n)
oppossum
(Monodelphis domestica)
Mammalia KAT2A 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT2A 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KAT2A 34 35
  • 83.84 (n)
lizard
(Anolis carolinensis)
Reptilia KAT2A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat2a 34
  • 76.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21330 34
zebrafish
(Danio rerio)
Actinopterygii kat2a 34 35
  • 77.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pcaf 34 35
  • 56.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004434 34
  • 55.73 (n)
worm
(Caenorhabditis elegans)
Secernentea pcaf-1 35
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN5 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5837 35
  • 56 (a)
OneToMany
Species where no ortholog for KAT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

(2) SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Sequence variations from dbSNP and Humsavar for KAT2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1052597 -- 42,113,502(-) TCTTT(C/T)TGGAC upstream-variant-2KB, utr-variant-3-prime
rs1055231 -- 42,123,097(+) GACAG(C/T)AGCAA upstream-variant-2KB, reference, stop-gained
rs111448692 -- 42,114,297(+) GAGAC(A/G)CCAAG intron-variant, upstream-variant-2KB
rs111822793 -- 42,116,383(+) TAACA(A/C)AGGAC intron-variant
rs112118069 -- 42,114,672(+) CAGTC(A/G)GAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
nsv1071384 CNV deletion 25765185
nsv1056904 CNV gain 25217958
esv2715947 CNV deletion 23290073
nsv953898 CNV deletion 24416366
nsv1146669 OTHER inversion 26484159

Variation tolerance for KAT2A Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene

Disorders for KAT2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KAT2A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KAT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KAT2A

Genetic Association Database (GAD)
KAT2A
Human Genome Epidemiology (HuGE) Navigator
KAT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT2A
genes like me logo Genes that share disorders with KAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene

Publications for KAT2A Gene

  1. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E. … Khochbin S. (J. Biol. Chem. 2001) 3 4 22 64
  2. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith E.R. … Allis C.D. (Nucleic Acids Res. 1998) 3 4 22 64
  3. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R. … Berger S.L. (Mol. Cell. Biol. 1996) 2 3 4 64
  4. A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. (PMID: 20224553) Lee H.S. … Kwon J. (EMBO J. 2010) 3 22 64
  5. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. (PMID: 19103755) Guelman S. … Zha J. (Mol. Cell. Biol. 2009) 3 4 64

Products for KAT2A Gene

Sources for KAT2A Gene

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