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Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • Lysine Acetyltransferase 2A 2 3 4 5
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • K(Lysine) Acetyltransferase 2A 2 3
  • Histone Acetyltransferase GCN5 3 4
  • EC 2.3.1.48 4 61
  • HsGCN5 3 4
  • GCN5L2 3 4
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • Histone Acetyltransferase KAT2A 3
  • PCAF-B 3

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Signaling by NOTCH1 and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.

UniProtKB/Swiss-Prot for KAT2A Gene

  • Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Gene Wiki entry for KAT2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

Regulatory Elements for KAT2A Gene

Enhancers for KAT2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G041986 1.2 dbSUPER 42.4 +133.8 133805 2.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF548 KAT2A CNTNAP1 ENSG00000267758 ENSG00000267765 HSD17B1 ZNF385C ENSG00000259623 LOC108783654 HSD17B1P1 CCR10
GH17G042420 1.7 FANTOM5 ENCODE dbSUPER 15.1 -300.6 -300551 5.2 PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ENSG00000267002 LINC00910 ENSG00000267340 KAT2A HMGN1P29 TUBG2 NAGLU ATP6V0A1 DHX58 P3H4
GH17G042308 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -194.7 -194664 15.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 TBX21 STAT5A HMGN1P29 CCR10 ENSG00000267002 CNTNAP1 STAT5B ATP6V0A1 CAVIN1 HSD17B1 DHX58
GH17G042405 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -287.7 -287744 6.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ENSG00000267002 HSD17B1 ENSG00000267340 KAT2A C17orf113 STAT3 WNK4 DHX58 NAGLU NT5C3B
GH17G041649 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +466.7 466748 9.8 HDGF PKNOX1 ARNT ZNF133 YBX1 FEZF1 BRCA1 YY1 TCF12 ZNF121 KRT14 DHX58 KRT37 KAT2A JUP ENSG00000236194 KRT17 KRT16 HAP1 KRT42P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KAT2A on UCSC Golden Path with GeneCards custom track

Promoters for KAT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094340 293 601 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 YY2 MXD4

Genomic Location for KAT2A Gene

Chromosome:
17
Start:
42,113,108 bp from pter
End:
42,121,393 bp from pter
Size:
8,286 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT14, MBIP and WDR5. Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with and acetylates HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Selected DME Specific Peptides for KAT2A Gene

Q92830:
  • YAIGYFKKQGF
  • EQVKGYGT

Post-translational modifications for KAT2A Gene

  • Ubiquitination at posLast=289289 and isoforms=2446
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

Domains & Families for KAT2A Gene

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Enzyme Numbers (IUBMB) for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 histone acetyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 17664281
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with KAT2A: view
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with KAT2A: view

Pathways & Interactions for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0006338 chromatin remodeling TAS 8552087
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KAT2A: view

Drugs & Compounds for KAT2A Gene

(5) Drugs for KAT2A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for KAT2A Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT2A: view

Drug Products

Transcripts for KAT2A Gene

Unigene Clusters for KAT2A Gene

K(lysine) acetyltransferase 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KAT2A

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A
ECgene alternative splicing isoforms for
KAT2A

Expression for KAT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2A Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT2A Gene



Protein tissue co-expression partners for KAT2A Gene

NURSA nuclear receptor signaling pathways regulating expression of KAT2A Gene:

KAT2A

SOURCE GeneReport for Unigene cluster for KAT2A Gene:

Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene:

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary.

Evidence on tissue expression from TISSUES for KAT2A Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Skin(4.3)
  • Eye(4.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with KAT2A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT2A 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia KAT2A 34 35
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Kat2a 34
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Kat2a 34 16 35
  • 90.66 (n)
cow
(Bos Taurus)
Mammalia KAT2A 34 35
  • 89.52 (n)
oppossum
(Monodelphis domestica)
Mammalia KAT2A 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT2A 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KAT2A 34 35
  • 83.84 (n)
lizard
(Anolis carolinensis)
Reptilia KAT2A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat2a 34
  • 76.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21330 34
zebrafish
(Danio rerio)
Actinopterygii kat2a 34 35
  • 77.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pcaf 34 35
  • 56.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004434 34
  • 55.73 (n)
worm
(Caenorhabditis elegans)
Secernentea pcaf-1 35
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN5 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5837 35
  • 56 (a)
OneToMany
Species where no ortholog for KAT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

(2) SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Sequence variations from dbSNP and Humsavar for KAT2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001558565 -- 42,120,961(+) CCGCC(C/T)CCACC intron-variant, upstream-variant-2KB
rs1001757855 -- 42,120,609(+) GCATC(C/T)TTGAT intron-variant
rs1002003211 -- 42,113,525(+) GGTCC(A/G)GAGGA upstream-variant-2KB, utr-variant-3-prime
rs1002580833 -- 42,122,337(+) CTCCT(C/G)GTGTC upstream-variant-2KB
rs1002779150 -- 42,122,036(+) AGGAT(A/C)GCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
esv2715947 CNV deletion 23290073
nsv1056904 CNV gain 25217958
nsv1071384 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv953898 CNV deletion 24416366

Variation tolerance for KAT2A Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KAT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene

Disorders for KAT2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KAT2A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KAT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KAT2A

Genetic Association Database (GAD)
KAT2A
Human Genome Epidemiology (HuGE) Navigator
KAT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KAT2A
genes like me logo Genes that share disorders with KAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene

Publications for KAT2A Gene

  1. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E. … Khochbin S. (J. Biol. Chem. 2001) 3 4 22 64
  2. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith E.R. … Allis C.D. (Nucleic Acids Res. 1998) 3 4 22 64
  3. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R. … Berger S.L. (Mol. Cell. Biol. 1996) 2 3 4 64
  4. A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. (PMID: 20224553) Lee H.S. … Kwon J. (EMBO J. 2010) 3 22 64
  5. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. (PMID: 19103755) Guelman S. … Zha J. (Mol. Cell. Biol. 2009) 3 4 64

Products for KAT2A Gene

  • Addgene plasmids for KAT2A

Sources for KAT2A Gene

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