Aliases for KAT2A Gene
External Ids for KAT2A Gene
Previous HGNC Symbols for KAT2A Gene
Previous GeneCards Identifiers for KAT2A Gene
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
GeneCards Summary for KAT2A Gene
KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Signaling by NOTCH1 and E2F transcription factor network. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.
UniProtKB/Swiss-Prot for KAT2A Gene
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.