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KAT2A Gene

protein-coding   GIFtS: 68
GCID: GC17M040265

K(Lysine) Acetyltransferase 2A

(Previous name: GCN5 general control of amino-acid synthesis 5-like 2 (yeast))
(Previous symbol: GCN5L2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
K(Lysine) Acetyltransferase 2A1 2     PCAF-b2
GCN5L21 2 3 5     GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 22
GCN52 3 5     General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 22
General Control Of Amino Acid Synthesis Protein 5-Like 22 3     hGCN52
Histone Acetyltransferase GCN52 3     Histone Acetyltransferase KAT2A2
Lysine Acetyltransferase 2A2 3     hsGCN52
STAF972 3     HGCN53
EC 2.3.1.483 8     HsGCN53
GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast)1     

External Ids:    HGNC: 42011   Entrez Gene: 26482   Ensembl: ENSG000001087737   OMIM: 6023015   UniProtKB: Q928303   

Export aliases for KAT2A gene to outside databases

Previous GC identifers: GC17M037519 GC17M036030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KAT2A Gene:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It
also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B
subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).(supplied by OMIM, Sep
2009)

GeneCards Summary for KAT2A Gene:
KAT2A (K(lysine) acetyltransferase 2A) is a protein-coding gene. Diseases associated with KAT2A include dosage-sensitive sex reversal, and retinal degeneration. GO annotations related to this gene include histone deacetylase binding and chromatin binding. An important paralog of this gene is BAZ1A.

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of
histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase
activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited
by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of
proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3
and H4

Gene Wiki entry for KAT2A (GCN5L2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KAT2A gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   Egr-4   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKAT2A promoter sequence
   Search Chromatin IP Primers for KAT2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KAT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21

KAT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT2A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040265:  view genomic region     (about GC identifiers)

Start:
40,265,126 bp from pter      End:
40,273,382 bp from pter
Size:
8,257 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 399,753-408,006     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT2A  
Size: 837 amino acids; 93926 Da
Subunit: Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L,
TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP.
Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H,
KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated
with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with and
acetylates HIV-1 Tat. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L,
TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP,
MBIP and WDR5. Interacts with PML (By similarity)
3 PDB 3D structures from and Proteopedia for KAT2A:
1F68 (3D)        1Z4R (3D)        3D7C (3D)    
Secondary accessions: Q8N1A2 Q9UCW1
Alternative splicing: 2 isoforms:  Q92830-1   Q92830-2   

Explore the universe of human proteins at neXtProt for KAT2A: NX_Q92830

Explore proteomics data for KAT2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys289, Lys446
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for KAT2A (Q92830)
     EQVKGYGT  YAIGYFKKQGF 


    See KAT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066564.2  
    ENSEMBL proteins: 
     ENSP00000225916   ENSP00000468390   ENSP00000467324  
    Reactome Protein details: Q92830

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    Selected InterPro protein domains (see all 6):
     IPR009464 PCAF_N
     IPR000182 GNAT_dom
     IPR018359 Bromodomain_CS
     IPR016376 Hist_acetylase_PCAF
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92830

    ProtoNet protein and cluster: Q92830

    2 Blocks protein domains:
    IPB001487 Bromodomain signature
    IPB009464 PCAF


    UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
    Similarity: Belongs to the acetyltransferase family. GCN5 subfamily
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 N-acetyltransferase domain


    KAT2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAT2A_HUMAN, Q92830
    Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of
    histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase
    activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited
    by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of
    proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3
    and H4
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding IPI17664281
    GO:0008080N-acetyltransferase activity ----
         
    KAT2A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KAT2A:
     Decreased p24 protein expressi 

         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Kat2a):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  mortality/aging  nervous system  normal  respiratory system 
     skeleton  vision/eye 

    KAT2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KAT2A: Kat2atm1Nkt Kat2atm3.1Roth

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KAT2A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KAT2A

    miRNA
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    miRTarBase miRNAs that target KAT2A:
    hsa-mir-615-3p (MIRT039857), hsa-mir-17-5p (MIRT050843), hsa-mir-331-3p (MIRT043446), hsa-mir-92a-3p (MIRT049612), hsa-mir-124-3p (MIRT022532), hsa-mir-1 (MIRT023698), hsa-mir-183-5p (MIRT047064)

    Block miRNA regulation of human, mouse, rat KAT2A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate KAT2A:
    hsa-miR-365 hsa-miR-550a hsa-miR-637 hsa-miR-122 hsa-miR-155 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidKAT2A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KAT2A

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAT2A_HUMAN, Q92830: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex ----
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386

    KAT2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KAT2A About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Clearance0.78
    HATs acetylate histones0.34
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    Chromatin organization0.34
    4Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Notch-HLH transcription pathway0.00
    Pre-NOTCH Transcription and Translation0.62
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for KAT2A
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for KAT2A
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for KAT2A
        Development Notch Signaling Pathway

    5 BioSystems Pathways for KAT2A
        Notch Signaling Pathway
    E2F transcription factor network
    Regulation of nuclear SMAD2/3 signaling
    C-MYC pathway
    Validated targets of C-MYC transcriptional activation

    Selected Reactome Pathways for KAT2A (see all 7)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    HATs acetylate histones
    Pre-NOTCH Transcription and Translation
    Notch-HLH transcription pathway


    4 Kegg Pathways  (Kegg details for KAT2A):
        Notch signaling pathway
    Thyroid hormone signaling pathway
    HTLV-I infection
    Viral carcinogenesis


    KAT2A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT2A: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KAT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KAT2A (Q928301, 2, 3 ENSP000002259164) via UniProtKB, MINT, STRING, and/or I2D (see all 368)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001843neural tube closure IEA--
    GO:0006325chromatin organization TAS--
    GO:0006338chromatin remodeling TAS8552087

    KAT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for KAT2A

    2 HMDB Compounds for KAT2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    1 DrugBank Compound for KAT2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coenzyme A-- 85-61-0target--10592235

    1 Novoseek inferred chemical compound relationship for KAT2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 52.3 3 17760996 (1), 18480452 (1), 19940161 (1)



    KAT2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KAT2A gene: 
    NM_021078.2  

    Unigene Cluster for KAT2A:

    K(lysine) acetyltransferase 2A
    Hs.463045  [show with all ESTs]
    Unigene Representative Sequence: NM_021078
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225916(uc002hyx.2) ENST00000465682 ENST00000586972 ENST00000588759
    ENST00000592310
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KAT2A

    Additional mRNA sequence: 

    AF029777.1 BC032743.1 BC039907.1 BC105977.1 

    11 DOTS entries:

    DT.100782516  DT.101976634  DT.454032  DT.100782517  DT.120956925  DT.120957022  DT.120956933  DT.97847268 
    DT.91982305  DT.92439173  DT.92024500 

    Selected AceView cDNA sequences (see all 939):

    BU528928 T16918 R73950 AW071488 CR612483 AL702429 AF498938 AA304768 
    AI520757 BI554166 BU148795 AI300457 AV703361 BE045640 BC032743 CR603551 
    CR591906 BE350297 BE676475 BM554081 AI361665 BE901116 BF436764 AI467843 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                      -                                                                                                   
    SP2:                                                                                                                                          
    SP3:                                                                                      -     -                                             
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for KAT2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KAT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGTCCAG
    KAT2A Expression
    About this image


    KAT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Ovary (Reproductive System)
     
     Adrenal Gland (Endocrine System)
    KAT2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KAT2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463045

    UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
    Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KAT2A: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KAT2A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kat2a1 , 5 K(lysine) acetyltransferase 2A1, 5 90.66(n)1
    99.21(a)1
      11 (63.53 cM)5
    145341  NM_001038010.21  NP_001033099.11 
     1007047465 
    chicken
    (Gallus gallus)
    Aves KAT2A1 K(lysine) acetyltransferase 2A 83.84(n)
    89.39(a)
      374232  XM_004948645.1  XP_004948702.1 
    lizard
    (Anolis carolinensis)
    Reptilia KAT2A6
    K(lysine) acetyltransferase 2A
    80(a)
    1 ↔ 1
    6(72877634-72901955)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.213302 Xenopus laevis transcribed sequence with strong similarity more 76.13(n)    BJ072879.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kat2a1 K(lysine) acetyltransferase 2A 77.41(n)
    88.06(a)
      555517  XM_001922697.4  XP_001922732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pcaf1 Pcaf 56.49(n)
    49.73(a)
      39431  NM_140329.3  NP_648586.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pcaf-16
    Protein PCAF-1 (pcaf-1) mRNA, complete cds
    30(a)
    many ↔ many
    I(3516478-3523387) WBGene00021636
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCN56
    Acetyltransferase, modifies N-terminal lysines on ...
    43(a)
    1 → many
    VII(996869-998188) YGR252W


    ENSEMBL Gene Tree for KAT2A (if available)
    TreeFam Gene Tree for KAT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KAT2A gene
    BAZ1A2  BPTF2  BAZ2B2  CECR22  BAZ2A2  BAZ1B2  KAT2B2  
    2 SIMAP similar genes for KAT2A using alignment to 3 protein entries:     KAT2A_HUMAN (see all proteins):
    KAT2B    BPTF

    KAT2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KAT2A (see all 187)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs176593911,2
    C,F,H--40266939(+) GGACAG/ACTCCG 2 /L syn1 ese313Minor allele frequency- A:0.05NA NS EA EU 6633
    rs1448138061,2
    F--40266982(+) ATCAGC/TGTCGC 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs1512664491,2
    C--40267087(+) CATCCA/GTAAGT 1 -- int10--------
    rs773362541,2
    C,F--40267110(+) CTGTCG/ATCCCT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1405054571,2
    --40267178(+) TCCTCC/TTGGGG 1 -- int10--------
    rs1866550631,2
    --40267249(+) ATCCCA/GAAGAG 1 -- int10--------
    rs20741661,2
    C,F,A,H--40267255(-) GGGGGA/GCTCTT 1 -- int121Minor allele frequency- G:0.32EA NS NA WA CSA 2781
    rs20741651,2
    C,F,A--40267299(-) AGGCTG/AGAGGA 1 -- int16Minor allele frequency- A:0.36NA WA CSA 11
    rs1450171181,2
    --40267529(+) CCCCAA/GTTCCT 1 -- int10--------
    rs1913560841,2
    --40267557(+) CCCCAC/TAGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for KAT2A (40265126 - 40273382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KAT2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715947CNV Deletion23290073
    dgv3169n71CNV Loss21882294
    nsv908241CNV Loss21882294
    nsv908240CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602301    OMIM disorders: --

    11 diseases for KAT2A:    
    About MalaCards
    dosage-sensitive sex reversal    retinal degeneration    hiv-1    cystic fibrosis
    lymphoblastic leukemia    retinitis    thyroiditis    leukemia
    malaria    lung cancer    breast cancer


    KAT2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): KAT2A
    Human Genome Epidemiology (HuGE) Navigator: KAT2A (1 document)

    Export disorders for KAT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KAT2A gene, integrated from 10 sources (see all 151):
    (articles sorted by number of sources associating them with KAT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087)1, 2, 3 Candau R....Berger S.L. (Mol. Cell. Biol. 1996)
    2. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PubMed id 11384967)1, 2, 9 Col E....Khochbin S. (J. Biol. Chem. 2001)
    3. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PubMed id 9611240)1, 2, 9 Smith E.R.... Allis C.D. (Nucleic Acids Res. 1998)
    4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (Mol. Cell 2008)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2 Gangisetty O.... Still I.H. (Oncogene 2004)
    7. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    8. The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)1, 2 Gangloff Y.G.... Davidson I. (Mol. Cell. Biol. 2001)
    9. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234)1, 2 McMahon S.B.... Cole M.D. (Mol. Cell. Biol. 2000)
    10. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. (PubMed id 11090279)1, 2 Hudson B.P.... Wright P.E. (J. Mol. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2648 HGNC: 4201 AceView: RAB5CandGCN5L2 Ensembl:ENSG00000108773 euGenes: HUgn2648
    ECgene: KAT2A Kegg: 2648 H-InvDB: KAT2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KAT2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KAT2A gene:
    Search GeneIP for patents involving KAT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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