Aliases for KAT2A Gene
External Ids for KAT2A Gene
Previous HGNC Symbols for KAT2A Gene
Previous GeneCards Identifiers for KAT2A Gene
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
GeneCards Summary for KAT2A Gene
KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and HTLV-I infection. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.
UniProtKB/Swiss-Prot for KAT2A Gene
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.