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Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • K(Lysine) Acetyltransferase 2A 2 3
  • GCN5L2 3 4 6
  • GCN5 3 4 6
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • Histone Acetyltransferase GCN5 3 4
  • Lysine Acetyltransferase 2A 3 4
  • EC 2.3.1.48 4 63
  • HsGCN5 3 4
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • Histone Acetyltransferase KAT2A 3
  • PCAF-B 3

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (K(Lysine) Acetyltransferase 2A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is BAZ1B.

UniProtKB/Swiss-Prot for KAT2A Gene

  • Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for KAT2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

Regulatory Elements for KAT2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KAT2A Gene

Start:
42,113,108 bp from pter
End:
42,121,393 bp from pter
Size:
8,286 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with and acetylates HIV-1 Tat. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP, MBIP and WDR5. Interacts with PML (By similarity).

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Proteomics data for KAT2A Gene at MOPED

Selected DME Specific Peptides for KAT2A Gene

Post-translational modifications for KAT2A Gene

  • Ubiquitination at Lys289 and Lys446
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KAT2A (GCN5)

Domains for KAT2A Gene

Gene Families for KAT2A Gene

HGNC:
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Q92830
Domain:
  • Contains 1 bromo domain.
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Enzyme Numbers (IUBMB) for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 17664281
GO:0008080 N-acetyltransferase activity --
genes like me logo Genes that share ontologies with KAT2A: view
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT2A

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KAT2A Gene COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with KAT2A: view

Pathways for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling TAS 8552087
genes like me logo Genes that share ontologies with KAT2A: view

Compounds for KAT2A Gene

(2) HMDB Compounds for KAT2A Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(1) Drugbank Compounds for KAT2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Coenzyme A
85-61-0 target

(1) Novoseek inferred chemical compound relationships for KAT2A Gene

Compound -log(P) Hits PubMed IDs
lysine 52.3 3
genes like me logo Genes that share compounds with KAT2A: view

Transcripts for KAT2A Gene

Unigene Clusters for KAT2A Gene

K(lysine) acetyltransferase 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KAT2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A
ECgene alternative splicing isoforms for
KAT2A

Expression for KAT2A Gene

mRNA expression in normal human tissues for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KAT2A Gene

SOURCE GeneReport for Unigene cluster for KAT2A Gene Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary
genes like me logo Genes that share expressions with KAT2A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT2A 35
  • 99.52 (n)
  • 99.52 (a)
KAT2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KAT2A 35
  • 89.52 (n)
  • 93.96 (a)
KAT2A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT2A 35
  • 92.79 (n)
  • 98.45 (a)
KAT2A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kat2a 35
  • 90.66 (n)
  • 99.21 (a)
Kat2a 16
Kat2a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KAT2A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT2A 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat2a 35
  • 90.96 (n)
  • 99.08 (a)
chicken
(Gallus gallus)
Aves KAT2A 35
  • 83.84 (n)
  • 89.39 (a)
KAT2A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT2A 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21330 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kat2a 35
  • 76.02 (n)
  • 88.4 (a)
zebrafish
(Danio rerio)
Actinopterygii kat2a 35
  • 77.41 (n)
  • 88.06 (a)
kat2a 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004434 35
  • 55.73 (n)
  • 53.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pcaf 35
  • 56.49 (n)
  • 49.73 (a)
Pcaf 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pcaf-1 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN5 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5837 36
  • 56 (a)
OneToMany
Species with no ortholog for KAT2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

Selected SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Sequence variations from dbSNP and Humsavar for KAT2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs730086 -- 42,119,739(-) TTTAT(C/T)CCCCA intron-variant, upstream-variant-2KB
rs2074163 -- 42,118,939(-) ACTCT(C/T)CAAGA intron-variant
rs2074164 -- 42,118,220(-) GCTCA(C/G)CTGGG intron-variant
rs2074165 -- 42,115,281(-) AGGCT(A/G)GAGGA intron-variant
rs2074166 -- 42,115,237(-) GGGGG(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
nsv908240 CNV Loss 21882294
nsv908241 CNV Loss 21882294
dgv3169n71 CNV Loss 21882294
esv2715947 CNV Deletion 23290073

Relevant External Links for KAT2A Gene

HapMap Linkage Disequilibrium report
KAT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene

Disorders for KAT2A Gene

Relevant External Links for KAT2A

Genetic Association Database (GAD)
KAT2A
Human Genome Epidemiology (HuGE) Navigator
KAT2A
genes like me logo Genes that share disorders with KAT2A: view

No data available for UniProtKB/Swiss-Prot for KAT2A Gene

Publications for KAT2A Gene

  1. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith E.R. … Allis C.D. (Nucleic Acids Res. 1998) 3 4 23
  2. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E. … Khochbin S. (J. Biol. Chem. 2001) 3 4 23
  3. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R. … Berger S.L. (Mol. Cell. Biol. 1996) 2 3 4
  4. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. (PMID: 8684459) Yang X.-J. … Nakatani Y. (Nature 1996) 3 4
  5. GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. (PMID: 15715965) Kikuchi H. … Nakayama T. (Gene 2005) 3 23

Products for KAT2A Gene

  • Addgene plasmids for KAT2A

Sources for KAT2A Gene

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