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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KAT2A Gene

protein-coding   GIFtS: 65
GCID: GC17M040265

K(lysine) acetyltransferase 2A

(Previous name: GCN5 general control of amino-acid synthesis 5-like 2 (yeast)...)
(Previous symbol: GCN5L2)
 Explore 12 diseases affiliated with
KAT2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KAT2A    

Aliases
for KAT2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
K(Lysine) Acetyltransferase 2A1 2     GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast)1
GCN51 2 3 5     GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 22
GCN5L21 2 3 5     General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 22
PCAF-B1     HGCN53
General Control Of Amino Acid Synthesis Protein 5-Like 22 3     Histone Acetyltransferase KAT2A2
Histone Acetyltransferase GCN52 3     HsGCN53
Lysine Acetyltransferase 2A2 3     HGCN53
STAF972 3     HsGCN53
EC 2.3.1.483 8     

External Ids:    HGNC: 42011   Entrez Gene: 26482   Ensembl: ENSG000001087737   OMIM: 6023015   UniProtKB: Q928303   

Export aliases for KAT2A gene to outside databases

Previous GC identifers: GC17M037519 GC17M036030


Summaries
for KAT2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KAT2A:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also
functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA
(MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).(supplied by OMIM, Sep 2009)

UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones
gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with
core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral
protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4

Gene Wiki entry for KAT2A (GCN5L2)


Genomic Views
for KAT2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KAT2A gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   Egr-4   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KAT2A promoter sequence
   Search SABiosciences Chromatin IP Primers for KAT2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KAT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21

KAT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KAT2A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040265:  view genomic region     (about GC identifiers)

Start:
 40,265,126 bp from pter      End:
 40,273,382 bp from pter
Size:
 8,257 bases      Orientation:
 minus strand

Proteins
for KAT2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830 (See protein sequence)
Recommended Name: Histone acetyltransferase KAT2A  
Size: 837 amino acids; 93926 Da
Subunit: Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L,
TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with
TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L,
TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex
required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with and acetylates HIV-1 Tat.
Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2,
CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP, MBIP and WDR5
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for KAT2A:
1F68 (3D)        1Z4R (3D)        3D7C (3D)    
Secondary accessions: Q8N1A2 Q9UCW1
Alternative splicing: 2 isoforms:  Q92830-1   Q92830-2   

Explore the universe of human proteins at neXtProt for KAT2A: NX_Q92830

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92830

    • 2 DME Specific Peptides for KAT2A (Q92830)
     EQVKGYGT  YAIGYFKKQGF 

    KAT2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066564.2  
    ENSEMBL proteins: 
     ENSP00000225916   ENSP00000468390   ENSP00000467324  
    Reactome Protein details: Q92830
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for KAT2A
    Uscn Proteins for KAT2A

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex ----
    GO:0005634nucleus ----
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386
    GO:0030914STAGA complex IDA11564863
    GO:0033276transcription factor TFTC complex IDA10373431


    KAT2A for ontologies           About GeneDecksing



    KAT2A Antibody Products: 
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    Uscn ELISAs and CLIAs for KAT2A

    Protein Domains /
    Families
    for KAT2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KAT2A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR009464 PCAF_N
     IPR000182 GNAT_dom
     IPR018359 Bromodomain_CS
     IPR016376 Hist_acetylase_PCAF
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q92830

    ProtoNet protein and cluster: Q92830

    2 Blocks protein families:
    IPB001487 Bromodomain signature
    IPB009464 PCAF


    UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
    Similarity: Belongs to the GCN5 family
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 N-acetyltransferase domain


    Function
    for KAT2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
    Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones
    gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with
    core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral
    protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
    Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

    Enzyme Number (IUBMB): EC 2.3.1.481 2

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate KAT2A:
    hsa-miR-365 hsa-miR-550a hsa-miR-637 hsa-miR-122 hsa-miR-155 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmid: KAT2A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding IPI--
    GO:0010484H3 histone acetyltransferase activity IDA18838386


    KAT2A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KAT2A:
     Decreased p24 protein expressi 

    Animal Models:
         Mouse knock-outs for KAT2A: Kat2atm1Nkt Kat2atm3.1Roth
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Kat2a):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  mortality/aging  nervous system  normal  respiratory system 
     skeleton  vision/eye 

    KAT2A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KAT2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/11 pathways (see all 11)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.71
    2Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    3Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    4Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Notch signaling pathway0.82
    5Mature NOTCH heterodimer traffics to the plasma membrane
    		Notch-HLH transcription pathway0.31
    		NICD traffics to nucleus0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for KAT2A
        Development Notch Signaling Pathway
    Histone modification


    1 Cell Signaling Technology (CST) Pathway for KAT2A
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for KAT2A
        Development Notch Signaling Pathway

    5 BioSystems Pathways for KAT2A 
        Notch Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional activation
    C-MYC pathway
    E2F transcription factor network

    5/17        Reactome Pathways for KAT2A (see all 17)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Notch-HLH transcription pathway
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    1         Kegg Pathway  (Kegg details for KAT2A):
        Notch signaling pathway


    KAT2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KAT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/201 Interacting proteins for KAT2A (Q928301, 2, 3 ENSP000002259164) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001843neural tube closure IEA--
    GO:0006338chromatin remodeling TAS8552087
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8552087


    KAT2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for KAT2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KAT2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KAT2A

    2 HMDB Compounds for KAT2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    1 DrugBank Compound for KAT2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coenzyme A-- 85-61-0target--10592235

    1 Novoseek chemical compound relationship for KAT2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 52.3 3 17760996 (1), 18480452 (1), 19940161 (1)

    Search CenterWatch for drugs/clinical trials and news about KAT2A 

    Transcripts
    for KAT2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KAT2A gene: 
    NM_021078.2  

    Unigene Cluster for KAT2A:

    K(lysine) acetyltransferase 2A
    Hs.463045  [show with all ESTs]
    Unigene Representative Sequence: NM_021078
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225916(uc002hyx.2) ENST00000465682 ENST00000586972 ENST00000588759
    ENST00000592310

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AF029777.1 BC032743.1 BC039907.1 BC105977.1 

    11 DOTS entries:

    DT.100782516  DT.101976634  DT.454032  DT.100782517  DT.120956925  DT.120957022  DT.120956933  DT.97847268 
    DT.91982305  DT.92439173  DT.92024500 

    24/939 AceView cDNA sequences (see all 939):

    AI359289 AI336069 BQ928580 BU181441 AL702498 CB106974 BX445994 AW297019 
    CB242121 BM562148 AW071488 CB529464 AI924879 BM823313 BM920001 CR622103 
    BU556704 AI285811 BI770732 CD630591 BP364342 BF876403 BM424202 CA488413 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                      -                                                                                                   
    SP2:                                                                                                                                          
    SP3:                                                                                      -     -                                             
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for KAT2A

    Expression
    for KAT2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KAT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTGTCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KAT2A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KAT2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KAT2A

    SOURCE GeneReport for Unigene cluster: Hs.463045

    UniProtKB/Swiss-Prot: KAT2A_HUMAN, Q92830
    Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including KAT2A: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cells in human mouse rat

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    Orthologs
    for KAT2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KAT2A gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KAT2A1 K(lysine) acetyltransferase 2A 82.35(n)
    88.02(a)    		   374232  NM_204329.1  NP_989660.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KAT2A6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 6(72877703-72899038)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.213302 Xenopus laevis transcribed sequence with strong similarity more 76.13(n)    BJ072879.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kat2a1 K(lysine) acetyltransferase 2A 76.49(n)
    86.62(a)    		   555517  XM_001922697.3  XP_001922732.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pcaf1 CG4107-PA 56.06(n)
    49.61(a)    		   39431  NM_140329.3  NP_648586.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea pcaf-11 Protein PCAF-1 43.38(n)
    34.43(a)    		   171920  NM_058772.5  NP_491173.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HAG11 histone acetyltransferase GCN5 51.06(n)
    45.09(a)    		   824626  NM_115318.2  NP_567002.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g04159001 hypothetical protein 48.4(n)
    42.47(a)    		   4348629  NM_001071139.1  NP_001064604.1 


    ENSEMBL Gene Tree for KAT2A (if available)
    TreeFam Gene Tree for KAT2A (if available) 

    Paralogs
    for KAT2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KAT2A gene
    BAZ1A2  BPTF2  BAZ2A2  BAZ2B2  CECR22  BAZ1B2  KAT2B2  
    2 SIMAP similar genes for KAT2A using alignment to 3 protein entries:     KAT2A_HUMAN (see all proteins):
    KAT2B    BPTF

    KAT2A for paralogs           About GeneDecksing



    Genomic Variants
    for KAT2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 NCBI SNPs in KAT2A are shown (see all 179)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1406687121,2
    		C,F,other40266059(+) CCTCCG/AACTTC 3 /S /L mis1 us2k11Minor allele frequency- A:0.00NA 2558
    rs22776211,2
    		C,F,A,H,--40264661(-) CCTACG/CTGGTG 2 -- ut51 int117Minor allele frequency- C:0.20EA NA NS WA CSA 2409
    rs15577431,2
    		F,--40264665(-) CAGGCC/ATACGT 2 -- int1 ut515Minor allele frequency- A:0.01EA NA MN 326
    rs1853875021,2
    		--40264717(+) TCAGCA/GCAGAG 2 -- ut51 int10--------
    rs1493968241,2
    		--40264771(+) GCTGAG/TCCGAC 2 -- int1 us2k10--------
    rs169674991,2
    		C,F,H,--40264893(+) AACCAC/TATCCA 2 -- us2k1 int114Minor allele frequency- T:0.04NA NS EA WA 2036
    rs47967701,2
    		C,F,A,H,--40264896(+) CACATC/ACACCC 2 -- us2k1 int116Minor allele frequency- A:0.09NS EA NA WA 2166
    rs733116381,2
    		C,--40264994(+) GCAGGC/AAGGTA 2 -- int1 us2k12Minor allele frequency- A:0.04WA 120
    rs1906905831,2
    		--40265049(+) GGGGAG/TAGCAG 2 -- us2k1 int10--------
    rs1836403261,2
    		--40265276(+) CAACCC/TCTGAA 2 -- us2k1 ut310--------

    HapMap Linkage Disequilibrium report for KAT2A (40265126 - 40273382 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KAT2A: --

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    Disorders / Diseases
    for KAT2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KAT2A for disorders           About GeneDecksing

    OMIM gene information: 602301    OMIM disorders: --

    12 diseases for KAT2A:    About MalaCards
    dosage-sensitive sex reversal    sex reversal    retinal degeneration    cystic fibrosis
    fibrosis    colon carcinoma    retinitis    breast cancer
    immunodeficiency    thyroiditis    carcinoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: KAT2A (1 document)

    Export disorders for KAT2A gene to outside databases

    Publications
    for KAT2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KAT2A gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with KAT2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087)1, 2, 3 Candau R....Berger S.L. (1996)
    2. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PubMed id 11384967)1, 2, 9 Col E....Khochbin S. (2001)
    3. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PubMed id 9611240)1, 2, 9 Smith E.R.... Allis C.D. (1998)
    4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (2008)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2 Gangisetty O.... Still I.H. (2004)
    7. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (2001)
    8. The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)1, 2 Gangloff Y.G.... Davidson I. (2001)
    9. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234)1, 2 McMahon S.B.... Cole M.D. (2000)
    10. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. (PubMed id 11090279)1, 2 Hudson B.P.... Wright P.E. (2000)

    External Searches for KAT2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing KAT2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2648 HGNC: 4201 AceView: RAB5CandGCN5L2 Ensembl:ENSG00000108773 euGenes: HUgn2648
    ECgene: KAT2A Kegg: 2648 H-InvDB: KAT2A

    Other Databases showing KAT2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KAT2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KAT2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KAT2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KAT2A gene:
    Search GeneIP for patents involving KAT2A

    GeneCards and IP:
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