Aliases for KARS Gene
External Ids for KARS Gene
Previous HGNC Symbols for KARS Gene
Previous GeneCards Identifiers for KARS Gene
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KARS Gene
KARS (Lysyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with KARS include Charcot-Marie-Tooth Disease, Recessive Intermediate, B and Deafness, Autosomal Recessive 89. Among its related pathways are Metabolism and tRNA Aminoacylation. GO annotations related to this gene include nucleic acid binding and tRNA binding.
UniProtKB/Swiss-Prot for KARS Gene
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.